Dissertations / Theses on the topic 'D-aspartate'
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Carlson, Stephen Lee. "Characterization of D-Aspartate Receptor Currents in Aplysia californica." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/478.
Full textSim, Neil. "Molecular imaging probes for N-methyl-D-aspartate receptors." Thesis, Durham University, 2014. http://etheses.dur.ac.uk/10816/.
Full textBera, Katarzyna D. "Autoantibodies to N-methyl D-aspartate receptors in autoimmune encephalitis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:6bbda982-ab5c-4982-b23a-0478c689869c.
Full textYassin, Maged M. I. "N-methyl-D-aspartate, anoxia and glutamate antagonists in mammalian brain." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241524.
Full textWu, Y. "Extrasynaptic signalling and plasticity mediated by N-Methyl-D-aspartate receptors." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1369568/.
Full textLui, Pik Wa. "Modulation of N-methyl-D-aspartate receptor expression in neuronal cell culture." HKBU Institutional Repository, 2002. http://repository.hkbu.edu.hk/etd_ra/419.
Full textLeMaistre, Jillian. "Regulation of brain blood flow by astrocyte D-serine and N-methyl-D-aspartate receptors." Journal of Cerebral Blood Flow and Metabolism, 2012. http://hdl.handle.net/1993/8585.
Full textRutter, Anthony Richard. "Biochemical and pharmacological characterisation of the interaction between NMDA receptors and the scaffolding protein PSD-95." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248043.
Full textKotecha, Suhas Ashok. "G-protein coupled receptor modulation of N-methyl-D-aspartate channel activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63766.pdf.
Full textTofighy, Azita. "N-methyl-d-aspartate receptor desensitisation and anoxia in rat olfactory cortex." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361309.
Full textTorres, Jacques-Henri. "Récepteur au n-méthyl-d-aspartate et souffrance neuronale du coma hypoglycémique." Montpellier 1, 1988. http://www.theses.fr/1988MON11381.
Full textElhallaoui, Menana. "Modélisation moléculaire d'antagonistes non compétitifs du récepteur NMDA [N-Méthyl-D-aspartate]." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2B003.
Full textNixon, Kimberly. "N-methyl-D-aspartate receptor subunit expression following perinatal exposure to ethanol /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Full textPaliouras, Grigorios Nikiforos. "Effect of ethanol on the Jak-Stat pathway : is this an NMDA mediated event?" Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79062.
Full textWenzel, Andreas. "Heterogeneity and developmental regulation of N-methyl-D-aspartate receptors in the brain /." Zürich, 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12006.
Full textWilson, John A. "The role of N-methyl D-aspartate (NMDA) receptor antagonists in neuropathic pain." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/25324.
Full textFan, Mannie Man Yee. "Mechanisms of modulation of N-methyl-D-aspartate (NMDA) receptors by mutant huntingtin." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/30863.
Full textMedicine, Faculty of
Graduate
Raouf, Ramin K. "Functional regulation of N-methyl-D-aspartate receptors by serine/threonine protein kinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0009/MQ29348.pdf.
Full textLomas, Lisa Madonia Picker Mitchell Jon. "Sex differences in opioid antinociception modulation by the N-methyl-D-aspartate system /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1441.
Full textTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology Behavioral Neuroscience." Discipline: Psychology; Department/School: Psychology.
Morgan, Elaine M. "The role of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243084.
Full textJocoy, Emily Laura. "NR2 subunits and their role in striatal N-methyl-D-aspartate receptor function." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872142721&sid=9&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textJezequel, Julie. "Impact of psychotomimetic molecules on glutamatergic N-Methyl-D-Aspartate receptors surface trafficking." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0232/document.
Full textGlutamatergic N-Methyl-D-Aspartate receptors (NMDAR) play a key role in many physiological processes, and their implication in the pathophysiology of several neuropsychiatric disorders is now well established. Multiple lines of evidence converge towards a dysregulation of the NMDAR in psychotic disorders such as schizophrenia (SCZ). However, the molecular and cellular deficits underlying NMDAR dysfunction remain misunderstood. By tightly controlling NMDAR synaptic localization, surface trafficking represents a powerful regulator of synaptic transmission. Could an alteration of NMDAR surface trafficking underlie NMDAR dysfunction and contribute to the emergence of psychotic disorders? To tackle this question, my PhD project aimed at investigating the impact of different psychotomimetic molecules on NMDAR surface trafficking. In the first part of my project, I explored the impact of NMDAR autoantibodies (NMDAR-Ab) from SCZ and healthy subjects. My results revealed that NMDAR-Ab from SCZ patients rapidly disturb NMDAR synaptic trafficking and distribution, through a loss of NMDAR-EphrinB2 receptor interaction, eventually preventing the induction of synaptic plasticity. In the second part of my PhD project, I showed that psychotomimetic NMDAR antagonists also alter NMDAR synaptic mobility and localization. Downregulation of PSD proteins expression prevented NMDAR antagonists-induced deficits, suggesting that such alterations ensue from modifications of NMDAR intracellular interactions. Taken together, these results demonstrate that psychotomimetic molecules profoundly impact NMDAR surface trafficking, supporting a pathogenic role of this unsuspected process in the emergence of psychotic symptoms
Steinmetz, Ralf Dirk. "Functional expression of recombinant N-methyl-D-aspartate (NMDA) receptors in eukaryotic cell lines." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961238070.
Full textKing, Rachel Marie. "NR2Aand NR2B containing N-methyl-D-aspartate receptors in synaptic plasticity during cortical development." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520637.
Full textRiedemann, Maria-Therese. "Corticosterone-induced changes in N-methyl-D-aspartate receptor-mediated transmission in the hippocampus." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550309.
Full textFoster, Brett Lucas. "Modulation of resting human electroencephalographic dynamics by N-methyl-D-aspartate Antagonist Nitrous Oxide." Swinburne Research Bank, 2009. http://hdl.handle.net/1959.3/69924.
Full textA thesis submitted for the degree of Doctorate of Philosophy, Brain Sciences Institute, Swinburne University of Technology - 2009. Typescript. Bibliography: p. 153-183.
Bright, Nieka L. "Glutamate Receptor, Ionotropic N-methyl-D-aspartate 2B Polymorphisms and Concussive Recovery in Athletes." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216565.
Full textPh.D.
Athletes vary in their ability to recover from concussions. Following a concussion, a pathophysiological cascade of events transpires, rendering symptoms. One such event, the indiscriminate release of the excitatory neurotransmitter glutamate, may result in hyperactivation of glutamate receptors (e.g., N-methyl-D-aspartate receptors [NMDARs]) and self-propagate a state of neurotoxicity that may be enhanced via the concomitant release of Ca2+, particularly through NMDARs containing the NR2B subunit. Genetic variation in regulatory regions of the glutamate receptor, ionotropic N-methyl-D-aspartate 2B (GRIN2B) gene, which codes for the NR2B subunit, may play a role in varied recovery among concussed athletes. Indeed, the rs1019385 promoter single nucleotide polymorphism (SNP) has been shown to alter transcription in dominant versus recessive allele carriers such that expression of the T allele results in increased upregulation of the GRIN2B gene. Therefore, the primary purpose of this study was to determine the association of this GRIN2B SNP and concussive recovery; a second GRIN2B SNP (rs890), in the 3'untranslated region, was also explored. A secondary purpose was to examine SNP associations with initial evaluation concussion severity scores. A triple-blind, between-subjects, genetic association design was utilized. The independent variable was genotype for both GRIN2B SNPs (rs1019385, rs890). The primary dependent variable, concussive recovery, was defined as the number of days from the time of injury until full return-to-play (RTP) clearance was granted by a university concussion center's physician; recovery was categorized as either normal (≤ 20 days) or prolonged (> 20 days). The secondary dependent variables were initial evaluation concussion severity scores and consisted of: (a) vestibulo-ocular reflex (VOR) result, (b) Balance Error Scoring System (BESS) sum, and (c) Immediate Postconcussion Assessment and Cognitive Testing (ImPACT) composite scores. Fifty-three, mostly White (69.7%), male (75.0%) concussed athletes (18.96 ± 6.31 years of age) participated in the study; two participants were excluded due to inconclusive genetic results. Participants were evaluated at a university concussion center per standardized concussion assessment battery, using the aforementioned severity indicators, and provided saliva samples for genotyping experiments. Follow-up visits were performed, as needed, until participants were asymptomatic and cleared for full RTP. No significant associations were demonstrated for the codominant (p = .35, p = .70), dominant (p = .39, p = 1.00) or recessive (p = .72, p = .51) genetic models for the rs1019385 and rs890 SNPs (respectively). Similarly, there were no significant differences in any initial evaluation severity scores between genotype for any genetic model. This exploratory study investigated the association between two GRIN2B SNPs and varied concussive recovery among athletes. Although no statistical and minimal clinical significance was demonstrated, future investigations should incorporate a larger sample and next-generation sequencing to investigate the 21,000 to 25,000 genes and their variations across the human genome as complex disorders (e.g., concussions) likely involve a multitude of genetic variations (and their interactions), many with small effects. Further elucidation of genetic factors involved in concussive recovery could equip clinicians with superior counseling methods and treatment options for athletes at-risk for prolonged recovery.
Temple University--Theses
Vasuta, Oana Cristina. "Functional regulation of N-methyl-D-aspartate receptor subtypes and their involvement in hippocampal plasticity." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/17410.
Full textShe, Kevin. "N-methyl-D-aspartate receptors of the central nervous system : network connectivity, trafficking, and plasticity." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43286.
Full textReynolds, Anna R. "Examination of Hippocampal N-Methyl-D-Aspartate Receptors Following Chronic Intermittent Ethanol Exposure In Vitro." UKnowledge, 2013. http://uknowledge.uky.edu/psychology_etds/14.
Full textSemos, Madeline Louise. "The role of N-methyl-D-aspartate receptors and nitric oxide in spinal nociceptive processing." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294627.
Full textHobbs, Catherine M. "The functional expression of N-methyl-D-aspartate glutamate-type receptors by megakaryocytes and platelets." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527791.
Full textThouin, Anaïs Chiara. "Investigating the effects of N-methyl-D-aspartate receptor autoantibodies on cortical oscillations in vitro." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3730.
Full textWendt, Stefan [Verfasser]. "Microglia sense cortical spreading depression via N-methyl-D-aspartate receptor dependent potassium currents / Stefan Wendt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1133074367/34.
Full textWard, Amie S. (Amie Sue). "Characterization of Tolerance and Cross-tolerance between Noncompetitive N-methyl-D-aspartate (NMDA) Antagonists in Rats Trained to Self-administer Ketamine." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278135/.
Full textMeddows, Elisabeth. "Identification of the molecular determinants important in the assembly of N-methyl-D-aspartate (NMDA) receptors." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365682.
Full textRing, Joshua Roderick. "SYNTHETIC AROMATIC AGMATINE ANALOGS AS ALLOSTERIC MODULATORS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNEL." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/413.
Full textBerry, Jennifer Nicole. "TIME-DEPENDENCE OF DISTAL-TO-PROXIMAL HIPPOCAMPAL NEURODEGENERATION PRODUCED BY N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/72.
Full textDavidson, Avril. "A biochemical investigation of the N-methyl-D-aspartate receptor in the rat central nervous system." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19668.
Full textMartin, Elodie. "Etude de l'impact des antagonistes du récepteur N-méthyl-D-aspartate (NMDA) dans la douleur neuropathique." Thesis, Université Clermont Auvergne (2017-2020), 2017. http://www.theses.fr/2017CLFAS012.
Full textN-methyl-D-aspartate (NMDA) receptor antagonists such as ketamine, dextromethorphan and memantine have gained an increasing interest in the management of neuropathic pain. In Pain Clinics, ketamine is widely used in the relief of neuropathic pain. However, its use in clinical practice is limited due to its numerous side effects. It is therefore necessary to propose to patients a drug relay with other NMDA receptor antagonists. This work is part of an academic program research dedicated to NMDA receptor antagonists in the management of neuropathic pain. Its first objective was to evaluate the antalgic effects of dextromethorphan and memantine. This randomized, single-blind, parallel-group, placebo-controlled study in 60 ketamine responder patients aimed also to assess the cognitive-emotional status of patients and their quality life. In parallel, a mechanistic study focusing on dextromethorphan was performed in 20 healthy volunteers in a randomized, double-blind, cross-over, placebo-controlled study. The objective was to investigate in a freeze-injury model the pharmacokinetic and mechanistic characteristics of the anti-nociceptive, central and cognitive effects of dextromethorphan as well as the genetic polymorphism involved in its response variability.In patients, the immediate analgesic effects of ketamine were confirmed with improved anxiety and depression scores, cognitive and affective aspects of pain, and different sleep parameters. However, memantine and dextromethorphan, compared to placebo, did not significantly increase the ketamine-induced analgesia. The analysis of the genetic polymorphism did not reveal any variability in the analgesic efficacy of these treatments. In healthy volunteers, dextromethorphan revealed anti-hyperalgesic effects following peripheral and central sensitization but no analgesic effect on acute heat pain. Moreover, the variability of the anti-nociceptive activity of dextromethorphan described in the literature seems to be more related to the genetic polymorphism of the CYP2D6 gene than to that of the CYP3A4,5 and ABCB1 genes. Finally, dextrorphan, the main active metabolite of dextromethorphan, appears to be responsible for the deleterious sedative and cognitive effects of the drug. These two clinical and mechanistic approaches concerning the curative effect of the NMDA receptor antagonists showed : 1 - in patients, the prolonged curative effect of ketamine and the interest of dextromethorphan and memantine in the management of the neuropathic pain-related cognitive-emotional and quality of life impairment; 2 - in healthy volunteers, the anti-hyperalgesic efficacy of dextromethorphan on peripheral and central sensitization and its sedative and cognitive side effects. In addition to these two studies, a randomized, double-blind, parallel-group, placebo-controlled clinical study is ongoing in 40 patients with chemotherapy-induced peripheral neuropathic pain subsequently to the treatment of breast cancer. In conclusion the assessment of the effects of dextromethorphan in two different populations led to discordant results. In the healthy volunteer, dextromethorphan exerts a marked anti-hyperalgesic effect and causes deleterious central effects. In the patient with peripheral neuropathic pain, only a trend is observed in favor of the anti-nociceptive effect of dextromethorphan given in ketamine responder patients. More studies with larger population are needed to determine the importance of the CYP2D6, CYP3A4,5 and ABCB1 genetic polymorphisms on the anti-nociceptive activity of dextromethorphan. The translational approach of this thesis does not allow a firm conclusion on the clinical use of dextromethorphan in the curative treatment of chronic peripheral neuropathic pain. The use of dextromethorphan as a preventive agent via other administration routes (i.e. local) or in combination with other drugs, all require further exploration in order to improve the benefit/risk ratio of this molecule
Yongtao, Zhang, and Zhang Yongtao. "Synthesis and structural characterization of silver (I)-(D-, L- and DL-) aspartate and silver (I)-(D- and L-) glutamate coordination polymers." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626799.
Full textDumontet, Charles. "Acide d-aspartique beta-hydroxamate : essai clinique de phase i/ii chez les patients atteints de sida." Lyon 1, 1991. http://www.theses.fr/1991LYO1M069.
Full textGreyling, Yolande. "N-methyl-D-aspartate (NMDA) and sigma receptor antagonism as neuroprotective strategy for polycyclic amines / Yolande Greyling." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4202.
Full textThesis (M.Sc. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2009.
Morgan, Celia Janet Ann. "An investigation of the acute and chronic effects of the N-methyl-D-aspartate receptor antagonist ketamine." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429564.
Full textDorville, Agnès. "Optimisation des propriétés des antagonistes des récepteurs N-méthyl-D-aspartate et cholecystokinine-B par modélisation moléculaire." Paris 5, 1993. http://www.theses.fr/1993PA05P608.
Full textMorel, Véronique. "Approche translationnelle de l'impact des antagonistes du récepteur NMDA (N-méthyl-D-aspartate) dans la douleur neuropathique." Thesis, Clermont-Ferrand 1, 2014. http://www.theses.fr/2014CLF1MM07.
Full textNMDA receptor antagonists are potentially interesting molecules in the management of neuropathic pain. Some of them, such as ketamine, generate numerous adverse effects, limiting their use in the clinic. Other molecules, such as memantine or dextromethorphan, have been the subject of numerous preclinical and clinical studies, the results of which, however, remain controversial. The objective of this thesis work was to determine the impact of these two molecules on neuropathic pain by evaluating their antinociceptive effects, and cellular events associated with the NMDA receptor via the phosphorylation of different residues of the NR2B subunit such as tyrosines 1336 and 1472 (pTyr 1336 NR2B and pTyr 1472 NR2B) and serine 1303 (pSer 1303 NR2B), in a model of neuropathic pain induced by spinal nerve ligation L5 in rats. Following encouraging preclinical results, a randomized, single-blind, placebo-controlled clinical study was conducted in 40 breast cancer patients undergoing mastectomy. The objective was to evaluate whether memantine administered prior to mastectomy could prevent the development of neuropathic pain and the impairment of cognition, quality of life and sleep that accompany the management of breast cancer. In animals, it has been shown that memantine, administered prior to surgery, prevents the development of neuropathic pain symptoms and impairment of cognitive processes. Densitometric analysis of western blots showed a decrease in spinal and supraspinal expression of pTyr 1472 NR2B in the insula and hippocampus of these same animals. On the other hand, when administered post-surgically, memantine has no effect on these different parameters. Concerning dextromethorphan, preclinical results showed that curative administration of this molecule in painful animals reverses the symptoms of neuropathic pain, restores spatial memory and leads to a decrease in the spinal expression of pTyr 1336 NR2B. In the clinic, results showed at 3 months post-surgery, 1- a significant decrease in pain intensity in patients treated with memantine compared to the placebo group, 2- an improvement in neuropathic pain symptoms associated with neoadjuvant chemotherapy, and 3- an improvement in the affective component of the St. Antoine's Pain Questionnaire. However, no significant differences were observed in cognition, quality of life and quality of sleep. The study of these 2 antagonists, memantine and dextromethorphan, allowed to determine two different approaches in the management of neuropathic pain via distinct molecular targets. In animals, memantine has a preventive effect on the development of neuropathic pain and on the degradation of cognitive processes via the decrease in spinal and supraspinal expression of pTyr 1472 NR2B, while dextromethorphan has a curative effect on these same parameters via the decrease in spinal expression of pTyr 1336 NR2B. Translated with www.DeepL.com/Translator (free version)
Abu, Izuddin Fahmy. "Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of neurodegenerative disorders." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38591/.
Full textLau, Wai Kit Jaeger. "Developmental expression of N-methyl-D-aspartate and gamma-aminobutyric acid receptors in the rat basal ganglia." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/535.
Full textBraganza, Elena Marie [Verfasser]. "Influence of the N-Methyl-D-Aspartate Receptor coagonist, D-Cycloserine, on Memory Consolidation and subsequent Learning under Sleep Deprivation / Elena Marie Braganza." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1224232801/34.
Full textMartel, Marc-Andre´. "Role of the NR2 subunit composition and intracellular C-terminal domain in N-methy-D-aspartate receptor signalling." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4228.
Full text