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Eckardt, J. R., R. Ramlau, R. Gervais, F. Shepherd, M. O’Brien, T. Ciuleanu, B. Dharan, P. Wissel, and G. Ross. "Compliance with oral topotecan in patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 7092. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.7092.
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7092 Background: Compliance with chemotherapy can affect treatment efficacy and patient safety. Selecting an oral chemotherapy regimen with good tolerability in appropriate patients is important. To determine general level of compliance of oral topotecan, a retrospective analysis was conducted on 3 international open-label, multicenter, 2-arm randomized, phase III studies of patients with NSCLC and SCLC. Methods: Patients were randomized to receive oral topotecan d1–5 q21d as follows: Study 387 (Ramlau et al, Proc ASCO, 2005) 2.3 mg/m2/d second-line vs IV docetaxel for NSCLC; Study 389 (Eckardt et al, Proc ASCO, 2005) 1.7 mg/m2/d first-line with cisplatin vs etoposide/cisplatin for extensive-disease SCLC; and Study 478 (O’Brien et al, Lung Cancer 2005) 2.3 mg/m2/d second-line vs best supportive care for SCLC. Oral topotecan was administered to the patient in the clinic on day 1 of each course and the patient was responsible for self-administering the oral capsules the remaining 4 days of dosing. Patient compliance was defined as 100x(sum of number of caps taken across courses)/(sum of number of caps dispensed across courses), where number of caps taken = number of caps dispensed-number of caps returned. Results: Accrual per arm was (387), 414 patients; (389) 389; (478) 71. In the treated population for all three groups, adherence to oral topotecan was high, with >90% of patients recording at least 90% overall compliance (Table). Mean age (% ≥65 years/%PS 2) was (387) 58.8 years (29.2%/14%), (389) 59.7 (32.6%/13%), and (478) 59.8 (33.8%/27%). Median oral topotecan dose intensity (% target) for each course was (387) 87%, (389) 95%, and (478) 98%. The most common reason for dose reductions or delays was hematological toxicity. Conclusions: Oral topotecan can be administered on an outpatient basis with a high degree of patient compliance in the treated population, which included those ≥65 years and those with poor PS. [Table: see text] [Table: see text]
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CHIN, Cherng, Tien-Hsiung WENG, Lih-Hsing HSU, and Shang-Chia CHIOU. "The Spanning Connectivity of the Burnt Pancake Graphs." IEICE Transactions on Information and Systems E92-D, no. 3 (2009): 389–400. http://dx.doi.org/10.1587/transinf.e92.d.389.
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Del-Claro, Kleber, and Helena Maura Torezan-Silingardi. "In search of unusual interactions. A commentary on: ‘Pollen adaptation to ant pollination: a case study from the Proteaceae’." Annals of Botany 126, no. 3 (July 21, 2020): iv—v. http://dx.doi.org/10.1093/aob/mcaa126.
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This article comments on: Nicola Delnevo, Eddie J van Etten, Nicola Clemente, Luna Fogu, Evelina Pavarani, Margaret Byrne and William D Stock, Pollen adaptation to ant pollination: a case study from the Proteaceae, Annals of Botany, Volume 126, Issue 3, 1 September 2020, Pages 377–389, https://doi.org/10.1093/aob/mcaa058.
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Baskal, Svetlana, Alexander Bollenbach, Bettina Henzi, Patricia Hafner, Dirk Fischer, and Dimitrios Tsikas. "Stable-Isotope Dilution GC–MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination." Molecules 27, no. 12 (June 15, 2022): 3850. http://dx.doi.org/10.3390/molecules27123850.
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Metformin (N,N-dimethylguanylguanidine) is one of the most prescribed drugs with pleiotropic, exerted in part by not fully elucidated mechanisms of action. We developed and validated a gas chromatography–mass spectrometry (GC–MS) method for the quantitative analysis of metformin (metformin-d0) in 10-µL aliquots of human serum and urine using N,N-[dimethylo-2H6]guanylguanidine (metformin-d6) as the internal standard. The method involves evaporation of the samples to dryness, derivatization with pentafluoropropionic (PFP) anhydride in ethyl acetate (30 min, 65 °C), and extraction into toluene. The negative-ion chemical ionization GC–MS spectra of the PFP derivatives contain a single intense ion with mass-to-charge (m/z) ratios of m/z 383 for metformin-d0 and m/z 389 for metformin-d6. Our results suggest that all amine/imine groups of metformin-d0 and metformin-d6 are converted to their N,N,N-tripentafluoropropionyl derivatives, which cyclize to form a symmetric triazine derivative, of which the non-ring amine group is amidated. Quantification was performed by selected-ion monitoring (SIM) of m/z 383 and m/z 389. Upon validation, the method was applied to determine serum and urine metformin concentrations in 19 patients with Becker muscular dystrophy (BMD). Serum and urine samples were collected at baseline (Visit I), after six weeks of supplementation (Visit II) with metformin (3 × 500 mg/d; metformin group; n = 10) or l-citrulline (3 × 1500 mg/d; citrulline group; n = 9) followed by a six-week supplementation with 3 × 500 mg/d of metformin plus 3 × 1500 mg/d l-citrulline. At Visit I, the metformin concentration in the serum and urine was very low in both groups. The metformin concentrations in the serum and urine of the patients who first took metformin (MET group) were higher at Visit II and Visit III. The metformin concentration in the serum and urine samples of the patients who first took l-citrulline (CITR group) were higher at Visit III. The serum and urine concentrations of metformin were insignificantly lower in the CITR group at Visit III. The mean fractional excretion (FE) rate of metformin was 307% (Visit II) and 322% (Visit III) in the MET group, and 290% in the CITR group (Visit III). This observation suggests the accumulation of metformin in the kidney and its secretion in the urine. The GC–MS is suitable to measure reliably circulating and excretory metformin in clinical settings.
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Modarelli, Giuseppe Carlo, Roberta Paradiso, Carmen Arena, Stefania De Pascale, and Marie-Christine Van Labeke. "High Light Intensity from Blue-Red LEDs Enhance Photosynthetic Performance, Plant Growth, and Optical Properties of Red Lettuce in Controlled Environment." Horticulturae 8, no. 2 (January 27, 2022): 114. http://dx.doi.org/10.3390/horticulturae8020114.
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Plant factories using artificial light to produce vegetables have high energy costs due to the high demand for electricity for lighting. Compared to conventional light sources, light-emitting diodes (LEDs) offer the possibility of tailoring the light spectrum and regulating light intensity and are more energy-efficient in terms of energy conversion regardless of the levels of lighting intensity. Optimal light intensity and daily light integral (DLI) requirements are key factors for plant growth; however, their values vary among species and varieties. Our experiment aimed to identify the best light intensity to produce lettuce plants in controlled environment. Lettuce plants of the type Batavia cv ‘Blackhawk’ were grown in plastic pots filled with perlite and peat (20:80 v/v) for 33 days in a growth chamber under blue (B, 20%) and red (R, 80%) LED light at a photosynthetic flux density of 130 µmol m−2 s−1 (BR 130, DLI 7.49 mol m−2 d−1), 259 µmol m−2 s−1 (BR 259, DLI 14.92 mol m−2 d−1), and 389 µmol m−2 s−1 (BR 389, DLI 22.41 mol m−2 d−1). Our results showed that increasing light intensity and DLI promotes net photosynthesis, sustains the electron transport rate (ETR), and stimulates the synthesis of anthocyanins and carotenoids, with positive results for plant photoprotection. Furthermore, the decreases in vegetation indexes (photochemical reflectance index (PRI), greenness, and modified chlorophyll absorption in reflectance index (MCARI1)) also indicate changes in photosynthetic pigment content in response to plant acclimation to different DLIs. Among the three light intensities, 389 µmol m−2 s−1 (DLI 22.41 mol m−2 d−1) gave the best results for growing Batavia red lettuce cv ‘Blackhawk’, since it enhances both production and qualitative traits. These results highlight the importance of a proper light intensity to promote plant growth and qualitative traits and to reach high production targets. Hence, preliminary screening of plant performance under different light treatments is recommended to optimise plant response to artificial lighting.
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Skouri, W., N. Boussetta, F. Ajili, S. Sayhi, L. Metoui, and B. Louzir. "Déficit en vitamine D dans la population tunisienne : à propos de 389 patients." Annales d'Endocrinologie 79, no. 4 (September 2018): 315–16. http://dx.doi.org/10.1016/j.ando.2018.06.363.
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Haavisto, Wonjeong, Julie Blaskewicz Boron, Sherry Willis, and Warner Schaie. "SOMATIC COMPLAINTS, A KEY FACTOR OF DEPRESSIVE SYMPTOMS ASSOCIATED WITH SUBJECTIVE MEMORY." Innovation in Aging 3, Supplement_1 (November 2019): S648. http://dx.doi.org/10.1093/geroni/igz038.2405.
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Abstract Prior research found depressive symptoms and subjective memory to be associated with objective memory (OM) performance. One key factor of subjective memory, as measured by the Memory Functioning Questionnaire (MFQ), is General Frequency of Forgetting (GFF). However, few studies focused on identifying specific factors of depressive symptoms when examining associations between depressive symptoms, subjective memory and OM. Using structural equation modeling, cross-sectional associations of factors in the CES-D (depressive symptoms) to the MFQ (subjective memory) and OM were investigated in the Seattle Longitudinal Study (mean Age=72.39; SD=8.28; mean Education=15.12; SD=2.76; 58.4% female). Differential associations of the CES-D factors with the MFQ factors [n=389; RMSEA=.031; CFI=.973; TLI=.966] and the GFF subscales [n=389; RMSEA=.033; CFI=.971; TLI=.964] resulted. Only the CES-D somatic complaints factor was significantly associated with the GFF factor (β= -.45, p <.001), suggesting that people with more somatic complaints reported more memory concerns. The CES-D somatic complaints factor was negatively associated with the frequency of forgetting in daily life (β=-.36, p< .001) and forgetting while reading subscales (β= -.33, p < .001), indicating individuals that reported more somatic complaints experienced more frequent memory failures when performing daily activities and reading. Overall, a key CES-D factor, somatic complaints, emerged as influential to subjective memory, whereas there was no relation to OM. Further study of the longitudinal associations between the CES-D factors and subjective and objective memory is essential to determine the potential impact on memory deficits.
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Van Laarhoven, Jan. "Titles and Subtitles of the Policraticus A Proposal." Vivarium 32, no. 2 (1994): 131–60. http://dx.doi.org/10.1163/156853494x00087.
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AbstractIntroduction and Prologue 489 lines Part I. Officials and their ado. total: 6.214 lines Bk. 1. Curial occupations: 1.309 lines a) starting-point 3 ch.: 70 l. b) games 5 ch.: 820 l. c) varieties of magic 5 ch.: 419 l. Bk. 2. The truth of signs: prol.: 14 1. 3.116 lines a) true and false signs 3 ch.: 142 1. b) exc.: Jerusalem A.D. 70 6 ch.: 385 1. c) sequel: signs 5 ch.: 127 l. d) dreams 3 ch.: 386 l. e) a problem 9 ch.: 1.272 l. f) prognostications 3 ch.: 790 l. Bk. 3. The falsehood of flattery: prol.: 26 l. 1.789 lines a) introduction 3 ch.: 194 1. b) flattery 4 ch.: 373 1. c) the theatre of life 2 ch.: 266 1. d) applications 6 ch.: 930 1. Part II. Public functions. total: 6.099 lines Bk. 4. The true sovereign: prol.: 21 1. 1.296 lines a) royal ethics 3 ch.: 258 l. b) a royal mirror from the O.T. 8 ch.: 926 l. c) conclusion I ch.: 91 1. Bk. 5. The body according to Plutarch (1): prol.: 20 l. 2.448 lines a) the comparison with the body 2 ch.: 74 1. b) the soul of the body 3 ch.: 389 1. c) the head of the body 3 ch.: 584 l. d) heart and bowels 1 ch.: 126 l. e) the flanks of the body 1 ch.: 218 l. f) eyes, ears and tongue 7 ch.: 1.037 l. Bk. 6. The body according to Plutarch (2): prol.: 34 1. 2.355 lines a) the hands of the body 19 ch.: 1.482 l. b) the feet of the body 1 ch.: 36 1. c) the commonwealth 4 ch.: 356 1. d) about lese-majesty 4 ch.: 372 1. e) general conclusion 2 ch.: 75 1. Part III. Philosophical reflections. total: 9.319 lines Bk. 7. Philosophy and ethics: prol.: 104 l. 3.716 lines a) which philosophy? 8 ch.: 786 1. b) how to attain a good philosophy? 7 ch.: 979 1. c) money and craving for power 5 ch.: 893 l. d) hypocrisy 3 ch.: 510 l. e) jealousy 2 ch.: 444 1. Bk. 8. Ethics, tyranny, and felicity: prol.: 45 1. 5.603 lines a) thirst for glory 5 ch.: 619 l. b) the five sense-organs 8 ch.: 2.225 l. c) true glory 3 ch.: 468 l. d) tyrannology 7 ch.: 1.858 l. e) conclusion 2 ch.: 388 1. Total: 166 chapters 22.121 lines
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Sangro, Bruno, Peter R. Galle, Robin Kate Kelley, Chaiyut Charoentum, Enrico N. De Toni, Yuriy Ostapenko, Jeong Heo, et al. "Patient-reported outcomes from the phase 3 HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): 4074. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.4074.
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4074 Background: In the Phase 3 HIMALAYA study (NCT03298451) of patients (pts) receiving first-line treatment for unresectable hepatocellular carcinoma (uHCC), a single priming dose of tremelimumab (T; anti-CTLA-4) plus durvalumab (D; anti-PD-L1) in the STRIDE regimen significantly improved overall survival (OS) vs sorafenib (S), and D monotherapy was noninferior to S for OS (Abou-Alfa et al. J Clin Oncol 2022;40[suppl 4]. Abs 379). Methods: A pre-planned secondary objective of HIMALAYA was to assess pt-reported outcomes (PROs) in pts receiving STRIDE (T 300 mg plus D 1500 mg [one dose] plus D 1500 mg once every 4 weeks [Q4W]; N=393) or D (1500 mg Q4W; N=389) vs S (400 mg twice daily; N=389). The European Organisation for Research and Treatment of Cancer (EORTC) 30-item Quality of Life (QoL) Questionnaire and the EORTC 18-item HCC QoL questionnaire were used to assess disease-related symptoms, physical functioning (PF), and Global Health Status (GHS)/QoL. Time to deterioration (TTD), defined as time from randomization to first clinically meaningful deterioration (worsening ≥10 points) confirmed at a subsequent visit or death, was assessed in pts with baseline scores ≤90 for symptoms or ≥10 for PF and GHS/QoL. Results: Across treatment arms, compliance rates for PROs were >77% at baseline and >70% overall. Baseline scores were comparable across treatment arms. TTD in fatigue, appetite loss, abdominal pain, PF, and GHS/QoL were significantly longer for both STRIDE and D vs S (Table). TTD in nausea and abdominal swelling were significantly longer for STRIDE vs S. Conclusions: The positive OS outcomes for STRIDE and D in pts receiving first-line treatment for uHCC in HIMALAYA were associated with clinically meaningful, pt-centered benefits, demonstrated by delayed worsening of disease-related symptoms, PF, and GHS/QoL vs S. Median TTD in months (95% CI) in PROs for STRIDE and D vs S. Clinical trial information: NCT03298451. [Table: see text]
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Sangro, Bruno, Peter R. Galle, Robin Kate Kelley, Chaiyut Charoentum, Enrico N. De Toni, Yuriy Ostapenko, Jeong Heo, et al. "Patient-reported outcomes from the phase 3 HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): 4074. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.4074.
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4074 Background: In the Phase 3 HIMALAYA study (NCT03298451) of patients (pts) receiving first-line treatment for unresectable hepatocellular carcinoma (uHCC), a single priming dose of tremelimumab (T; anti-CTLA-4) plus durvalumab (D; anti-PD-L1) in the STRIDE regimen significantly improved overall survival (OS) vs sorafenib (S), and D monotherapy was noninferior to S for OS (Abou-Alfa et al. J Clin Oncol 2022;40[suppl 4]. Abs 379). Methods: A pre-planned secondary objective of HIMALAYA was to assess pt-reported outcomes (PROs) in pts receiving STRIDE (T 300 mg plus D 1500 mg [one dose] plus D 1500 mg once every 4 weeks [Q4W]; N=393) or D (1500 mg Q4W; N=389) vs S (400 mg twice daily; N=389). The European Organisation for Research and Treatment of Cancer (EORTC) 30-item Quality of Life (QoL) Questionnaire and the EORTC 18-item HCC QoL questionnaire were used to assess disease-related symptoms, physical functioning (PF), and Global Health Status (GHS)/QoL. Time to deterioration (TTD), defined as time from randomization to first clinically meaningful deterioration (worsening ≥10 points) confirmed at a subsequent visit or death, was assessed in pts with baseline scores ≤90 for symptoms or ≥10 for PF and GHS/QoL. Results: Across treatment arms, compliance rates for PROs were >77% at baseline and >70% overall. Baseline scores were comparable across treatment arms. TTD in fatigue, appetite loss, abdominal pain, PF, and GHS/QoL were significantly longer for both STRIDE and D vs S (Table). TTD in nausea and abdominal swelling were significantly longer for STRIDE vs S. Conclusions: The positive OS outcomes for STRIDE and D in pts receiving first-line treatment for uHCC in HIMALAYA were associated with clinically meaningful, pt-centered benefits, demonstrated by delayed worsening of disease-related symptoms, PF, and GHS/QoL vs S. Median TTD in months (95% CI) in PROs for STRIDE and D vs S. Clinical trial information: NCT03298451. [Table: see text]
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Abou-Alfa, Ghassan K., Stephen Lam Chan, Masatoshi Kudo, George Lau, Robin Kate Kelley, Junji Furuse, Wattana Sukeepaisarnjaroen, et al. "Phase 3 randomized, open-label, multicenter study of tremelimumab (T) and durvalumab (D) as first-line therapy in patients (pts) with unresectable hepatocellular carcinoma (uHCC): HIMALAYA." Journal of Clinical Oncology 40, no. 4_suppl (February 1, 2022): 379. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.379.
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379 Background: A single priming dose of T (anti-CTLA-4) added to D (anti-PD-L1) in the STRIDE (Single T Regular Interval D) regimen, formerly T300+D, showed encouraging clinical activity and limited toxicity in a phase 2 uHCC study (Study 22, NCT02519348), suggesting single exposure to T is sufficient to improve upon D activity. HIMALAYA (NCT03298451) evaluated the efficacy and safety of STRIDE or D vs sorafenib (S) in uHCC. Methods: HIMALAYA is an open-label, multicenter, phase 3 study, in which pts with uHCC and no prior systemic therapy were initially randomized to STRIDE (T 300 mg plus D 1500 mg [one dose] plus D 1500 mg every 4 weeks [Q4W]), D (1500 mg Q4W), S (400 mg twice daily), or T 75 mg Q4W (4 doses) plus D 1500 mg Q4W (T75+D). Recruitment to T75+D ceased after a planned analysis of Study 22 showed T75+D did not meaningfully differ from D. The primary objective was overall survival (OS) for STRIDE vs S. The secondary objective was OS noninferiority (NI) of D to S (NI margin: 1.08). Secondary endpoints included progression-free survival (PFS), objective response rate (ORR; RECIST v.1.1), duration of response (DoR), and safety. Results: In total, 1171 pts were randomized to STRIDE (N=393), D (N=389), or S (N=389). At data cutoff (DCO), the primary objective was met: OS was significantly improved for STRIDE vs S (hazard ratio [HR], 0.78; 96% confidence interval [CI], 0.65–0.92; p=0.0035; Table). D met the objective of OS NI to S (HR, 0.86; 96% CI, 0.73–1.03). ORRs were higher for STRIDE (20.1%) and D (17.0%) than for S (5.1%). No new safety signals were identified. Grade 3/4 treatment-related adverse events (TRAEs) occurred in 25.8% (STRIDE), 12.9% (D), and 36.9% (S) of pts. Grade 3/4 hepatic TRAEs occurred in 5.9% (STRIDE), 5.2% (D), and 4.5% (S) of pts. No TRAE of esophageal varices hemorrhage occurred. Rates of TRAEs leading to discontinuation were 8.2% (STRIDE), 4.1% (D), and 11.0% (S). Conclusions: HIMALAYA was the first large phase 3 trial with a diverse, representative uHCC population and extensive long-term follow-up to assess both mono- and combination immunotherapy. D was noninferior to S with favorable safety. The combination of a single priming dose of T plus D in STRIDE displayed superior efficacy and a favorable benefit-risk profile vs S. STRIDE is a proposed, novel, first-line standard of care systemic therapy for uHCC. Clinical trial information: NCT03298451. [Table: see text]
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Zhuo, Yafen, Lin Ling, Zhichun Sun, Wensen Huang, Zhenzhen Hong, Yaping Zhang, Xuefeng Peng, et al. "Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China." Open Life Sciences 16, no. 1 (January 1, 2021): 150–59. http://dx.doi.org/10.1515/biol-2021-0019.
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Abstract The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.
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Wadzinski, B. E., M. F. Shanahan, K. B. Seamon, and A. E. Ruoho. "Localization of the forskolin photolabelling site within the monosaccharide transporter of human erythrocytes." Biochemical Journal 272, no. 1 (November 15, 1990): 151–58. http://dx.doi.org/10.1042/bj2720151.
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Chemical and proteolytic digestion of intact erythrocyte glucose transporter as well as purified transporter protein has been used to localize the derivatization site for the photoaffinity agent 3-[125I]iodo-4-azido-phenethylamino-7-O-succinyldeacetylforskol in [(125I]IAPS-forskolin). Comparison of the partial amino acid sequence of the labelled 18 kDa tryptic fragment with the known amino acid sequence for the HepG2 glucose transporter confirmed that the binding site for IAPS-forskolin is between the amino acid residues Glu254 and Tyr456. Digestion of intact glucose transporter with Pronase suggests that this site is within the membrane bilayer. Digestion of labelled transporter with CNBr generated a major radiolabelled fragment of Mr approximately 5800 putatively identified as residues 365-420. Isoelectric focusing of Staphylococcus aureus V8 proteinase-treated purified labelled tryptic fragment identified two peptides which likely correspond to amino acid residues 360-380 and 381-393. The common region for these radiolabelled peptides is the tenth putative transmembrane helix of the erythrocyte glucose transporter, comprising amino acid residues 369-389. Additional support for this conclusion comes from studies in which [125I]APS-forskolin was photoincorporated into the L-arabinose/H(+)-transport protein of Escherichia coli. Labelling of this transport protein was protected by both cytochalasin B and D-glucose. The region of the erythrocyte glucose transporter thought to be derivatized with IAPS-forskolin contains a tryptophan residue (Trp388) that is conserved in the sequence of the E. coli arabinose-transport protein.
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Costenbader, K. H., D. Feskanich, M. Holmes, E. W. Karlson, and E. Benito-Garcia. "Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women." Annals of the Rheumatic Diseases 67, no. 4 (July 31, 2007): 530–35. http://dx.doi.org/10.1136/ard.2007.072736.
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Objectives:Vitamin D has immune-modulating effects and may protect against the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Methods:We identified incident cases of SLE and RA among 186 389 women followed from 1980 to 2002 in the Nurses’ Health Study and Nurses’ Health Study II cohorts. We excluded subjects where SLE or RA was not confirmed by medical record review, and those who failed to return questionnaires. Semi-quantitative food frequency questionnaires assessed vitamin D intake from food and supplements. We used cumulative-updated total energy-adjusted dietary exposures for each 2-year cycle. Relationships between vitamin D intake and incident SLE and RA were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results were pooled using meta-analysis random effects models.Results:We confirmed 190 incident cases of SLE and 722 of RA with dietary information. Increasing levels of vitamin D intake had no relationship to the relative risk of developing either SLE or RA.Conclusions:Vitamin D intake was not associated with risk of SLE or RA in these large prospective cohorts of women.
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Kelley, George A., and Kristi S. Kelley. "Effects of Diet, Aerobic Exercise, or Both on Non-HDL-C in Adults: A Meta-Analysis of Randomized Controlled Trials." Cholesterol 2012 (November 8, 2012): 1–5. http://dx.doi.org/10.1155/2012/840935.
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Purpose. To use the meta-analytic approach to examine the effects of diet (D), aerobic exercise (E), or both (DE) on non-high-density lipoprotein cholesterol (non-HDL-C) in adults. Methods. Randomized controlled trials in adults ≥18 years of age were included. A mixed-effect model was used to combine effect size (ES) results within each subgroup and to compare subgroups (Qb). Heterogeneity was examined using the Q and I2 statistics, and 95% confidence intervals (CI) were also calculated. Statistical significance was set at P≤0.05, while a trend for statistical significance was set between P>0.05, and ≤0.10. Results. A statistically significant exercise minus control group decrease in non-HDL-C was found for DE (7 ESs, 389 participants, x¯=-11.1 mg/dL, 95% CI=−21.7 to −0.6, P=0.04, Q=2.4, P=0.88, I2=0%), a trend for the D group (7 ESs, 402 participants, x¯=−8.5 mg/dL, 95% CI=−18.6 to 1.6, P=0.10, Q=0.76, P=0.99, I2=0%), and no change for the E group (7 ESs, 387 participants, x¯=3.0 mg/dL, 95% CI=−7.1 to 13.1, P=0.56, Q=0.78, P=0.99, I2=0%). Overall, no statistically significant between-group differences were found (Qb=4.1, P=0.12). Conclusions. Diet combined with aerobic exercise may reduce non-HDL-C among adults in some settings.
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Kalin, R., T. Turan, M. Ozan Atasoy, and H. Isidan. "Characterization of fowl aviadenovirus species in backyard flocks in Turkey." Journal of the Hellenic Veterinary Medical Society 73, no. 3 (October 26, 2022): 4667–74. http://dx.doi.org/10.12681/jhvms.28046.
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Fowl aviadenovirus infections show a worldwide distribution in poultry at all ages and the incidence of the disease is increasing year after year. Most of the studies have been exhibited the situation of the disease in commercial chickens especially in broilers but there is not sufficient data to estimate in backyards. Totally 389 internal organ samples were collected from 56 flocks from suspicious backyard chickens at ages between 10-35 weeks. Samples were tested by PCR method and nucleotide sequences of hexon genes were used for phylogenetic analyses and comparing with other FAdV sequences submitted to GenBank. Of the 389 samples, 23.9% were found FAdV positive and 30.4% (17/56) of the flocks sampled in the study were infected. This is the first study that was carried out in backyards and two species (D and C) and four serotypes (FAdV-8a, FAdV-3, FAdV-4, and FAdV-10) have been discovered for the first time in Turkey. To understand the epidemiology of FAdV in Turkey and to get enough information about species and serotypes further large scale national studies should be carried out to determine the severity of FAdV infections and to plan control strategies.
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Polkovnikov, Anatoli, Subir Sachdev, and Matthias Vojta. "Erratum to: “Spin collective mode and quasiparticle contributions to STM spectra of d-wave superconductors with pinning” [Physica C 388–389 (2003) 19–24]." Physica C: Superconductivity 391, no. 4 (September 2003): 381. http://dx.doi.org/10.1016/s0921-4534(03)01210-3.
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Ownby, Raymond L. "Rourke, B. P., Bakker, D. J., Fisk, J. L., & Strang, J. D. (1983). Child neuropsychology. New York: Guilford Press, 389 pp., $29.50." Psychology in the Schools 23, no. 2 (April 1986): 219–22. http://dx.doi.org/10.1002/1520-6807(198604)23:2<219::aid-pits2310230218>3.0.co;2-o.
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Ravishankar, K. "Re: “Daily Migraine With Aura: A New Migraine Variant” (Merims D, Kuritzky A. Headache . 2000;40:389‐392)." Headache: The Journal of Head and Face Pain 41, no. 1 (January 2001): 102. http://dx.doi.org/10.1046/j.1526-4610.2001.111006102.x.
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Vanderlinde, Thyago, Eduardo Guimarães Dupim, Nestor O. Nazario-Yepiz, and Antonio Bernardo Carvalho. "An Improved Genome Assembly for Drosophila navojoa, the Basal Species in the mojavensis Cluster." Journal of Heredity 110, no. 1 (November 13, 2018): 118–23. http://dx.doi.org/10.1093/jhered/esy059.
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Abstract Three North American cactophilic Drosophila species, D. mojavensis, D. arizonae, and D. navojoa, are of considerable evolutionary interest owing to the shift from breeding in Opuntia cacti to columnar species. The 3 species form the “mojavensis cluster” of Drosophila. The genome of D. mojavensis was sequenced in 2007 and the genomes of D. navojoa and D. arizonae were sequenced together in 2016 using the same technology (Illumina) and assembly software (AllPaths-LG). Yet, unfortunately, the D. navojoa genome was considerably more fragmented and incomplete than its sister species, rendering it less useful for evolutionary genetic studies. The D. navojoa read dataset does not fully meet the strict insert size required by the assembler used (AllPaths-LG) and this incompatibility might explain its assembly problems. Accordingly, when we re-assembled the genome of D. navojoa with the SPAdes assembler, which does not have the strict AllPaths-LG requirements, we obtained a substantial improvement in all quality indicators such as N50 (from 84 kb to 389 kb) and BUSCO coverage (from 77% to 97%). Here we share a new, improved reference assembly for D. navojoa genome, along with a RNAseq transcriptome. Given the basal relationship of the Opuntia breeding D. navojoa to the columnar breeding D. arizonae and D. mojavensis, the improved assembly and annotation will allow researchers to address a range of questions associated with the genomics of host shifts, chromosomal rearrangements and speciation in this group.
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Rousselot, Philippe, Hyacinthe Johnson-Ansah, Françoise Huguet, Laurence Legros, Martine Escoffre-Barbe, Martine Gardembas, Pascale Cony-Makhoul, et al. "Personalized Daily Doses of Imatinib By Therapeutic Drug Monitoring Increase the Rates of Molecular Responses in Patients with Chronic Myeloid Leukemia. Final Results of the Randomized OPTIM Imatinib Study." Blood 126, no. 23 (December 3, 2015): 133. http://dx.doi.org/10.1182/blood.v126.23.133.133.
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Abstract Background Imatinib mesylate (IM) at 400 mg/d remains a standard for first line therapy in patients (pts) with newly diagnosed chronic phase CML (CP-CML). A sub analysis of the IRIS study (Larson et al. Blood, 2008) demonstrated that pts with high IM trough levels achieved higher rates of major molecular response (MMR). The level of 1000 ng/ml was established as the [C]min value threshold to predict molecular response (Picard et al. Blood, 2007). We conducted a randomized trial to evaluate the value of IM dose optimization based on the monitoring of [C]min levels in newly diagnosed CP-CML pts (OPTIM-imatinib trial, EudraCT number 2008-006854-17). Patients and Methods Pts diagnosed with CP- CML for less than 3 months, not previously treated or treated with IM for less than 3 months were eligible and treated with IM 400 mg/d. IM [C]min was determined by chromatography-tandem mass-mass spectrometry 15 days after enrollment. Pts with a [C]min < 1000 ng/ml were randomized between a dose-increase strategy aiming to reach the threshold of 1000 ng/ml (arm A1) versus standard IM management (arm A2). Pts with [C]min levels ≥1000 ng/ml were observed (arm A3). All pts were managed according to the ELN 2009 recommendations (amended with ELN 2013 recommendations). IM [C]min levels were assessed monthly in A1 and A2 and every 3 months in A3. BCR-ABLIS was assessed every 3 months. The primary end-point was MMR rates at 12 months. Results One hundred thirty nine pts were enrolled. Median follow-up was 31 months. Median age was 64y (25 to 88y), sex ratio (M/F) was 1.4 and Sokal score distribution was 21%, 41% and 38% for high, intermediate and low categories respectively, equally distributed in the 3 arms. In 6 pts the initial [C]min was not assessed (3 were intolerant and 3 declined the dosage). Thus 133 pts were studied. In 86 pts (65%), initial [C]min value was < 1000 ng/ml. These pts were randomized between A1 (43 pts) and A2 (43 pts). [C]min was ≥1000 ng/ml in the 47 remaining pts followed in A3. Table 1 shows the significant improvement of the median IM [C]min after dose adjustment in A1 (p<0.0001) as compared to standard management in A2. Correspondingly, IM daily dose increased in A1 (p<0.0001) to reach a mean value of 600 mg/d. In the experimental A1 arm, the distribution of IM doses at 12 months was 13% for 500 mg/d, 30% for 600 mg/d, 34% for 800 mg/d whereas 16% of the pts remained at 400 mg/d and 7% were dose decreased at 300 mg/d. During follow-up, a similar proportion of pts with AE was observed in A1 (58%) and A2 (51%). Eight SAE related to IM were equally distributed in A1, A2 and A3. Cumulative incidences of treatment discontinuation were comparable in the 3 arms (overall, 18.8% by 12 months and 34.1% by 24 months). Reasons for discontinuation were not similar in A1 and A2 with a trend for more treatment failures in A2 as compared to A1 (60% versus 18%, p=0.08). At 12 months, MMR was achieved in 27 out of 43 pts (63%; 95%CI 49-77) in A1 as compared to 16 out 43 pts (37%; 95%CI 23-51) in A2 (p=0,031). The rates of MMR were not statistically different between A1 and A3 (p=0.12). Conclusions Only 1/3 of pts on IM400 were correctly dosed and may not require systematic high dose IM. Two-thirds of the pts were not exposed enough to IM at standard dose and may benefit from individualized strategies. A tailored dose adjustment based on pharmacology resulted in higher MMR rate at 12 months (63% vs 37%), a magnitude in line with the results previously reported with second generation tyrosine kinase inhibitors or high dose IM front line. Our results may provide a strong rational to early personalize the use of IM and IM generic formulations in order to optimize the outcome for each patient. This study was supported by a grant from the French Department of Health (Programme Hospitalier de Recherche Clinique). Table 1. Median [C]min (ng/ml; (95% CI)) Initial Assessment M3 M6 M9 M12 A1 591; (508-654) 838; (746-922) 1001; (748-1261) 1062; (918-1221) 1013; (830-1277) A2 651; (558-797) 605; (487-786) 591; (517-722) 605; (460-720) 646; (576-894) A3 1314; (1199-1514) 1032; (899-1143) 1002; (784-1205) 935; (737-1073) 1000; (846-1098) Mean IM daily dose (mg/d; (95% CI)) Inclusion M3 M6 M9 M12 A1 400 538; (508-568) 611; (563-658) 607; (545-668) 600; (535-665) A2 400 395; (387-402) 392; (383-401) 391; (381-401) 391; (381-401) A3 400 400; (400-400) 398; (385-410) 389; (376-402) 382; (370-395) Disclosures Rousselot: BMS: Consultancy, Speakers Bureau; Novartis: Speakers Bureau; Pfizer: Consultancy. Johnson-Ansah:BMS: Speakers Bureau; Hybrigenics SA: Consultancy, Research Funding; Novartis: Consultancy, Speakers Bureau. Huguet:PFIZER: Consultancy, Speakers Bureau; ARIAD: Consultancy, Speakers Bureau; BMS: Consultancy, Speakers Bureau; Novartis: Consultancy, Research Funding. Legros:Novartis: Research Funding, Speakers Bureau; ARIAD: Speakers Bureau; BMS: Speakers Bureau. Gardembas:Novartis: Speakers Bureau. Coiteux:ARIAD: Speakers Bureau; BMS: Speakers Bureau; Novartis: Speakers Bureau. Deau:BMS: Honoraria. Mahon:ARIAD: Consultancy; Pfizer: Consultancy; Bristol-Myers Squibb: Consultancy, Honoraria; Novartis: Consultancy, Honoraria.
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Akhavein, F., E. Jean St.-Michel, E. Seifert, and C. V. Rohlicek. "Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats." Journal of Applied Physiology 103, no. 1 (July 2007): 287–95. http://dx.doi.org/10.1152/japplphysiol.01509.2005.
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Decreased right as well as left ventricular function can be associated with pulmonary hypertension (PH). Numerous investigations have examined cardiac function following induction of pulmonary hypertension with monocrotaline (MCT) assuming that MCT has no direct cardiac effect. We tested this assumption by examining left ventricular function and histology of isolated and perfused hearts from MCT-treated rats. Experiments were performed on 50 male Sprague-Dawley rats [348 ± 6 g (SD)]. Thirty-seven rats received MCT (50 mg/kg sc; MCT group) while the remainder did not (Control group). Three weeks later, pulmonary artery pressure was assessed echocardiographically in 20 MCT and 8 Control rats. The hearts were then excised and perfused in the constant pressure Langendorff mode to determine peak left ventricular pressure (LVP), the peak instantaneous rate of pressure increase (+dP/d tmax) and decrease (−dP/d tmax), as well as the rate pressure product (RPP). Histological sections were subsequently examined. Pulmonary artery pressure was higher in the MCT-treated group compared with the Control group [12.9 ± 6 vs. 51 ± 35.3 mmHg ( P < 0.01)]. Left ventricular systolic function and diastolic relaxation were decreased in the MCT group compared with the Control group (+dP/d tmax4,178 ± 388 vs. 2,801 ± 503 mmHg/s, LVP 115 ± 11 vs. 83 ± 14 mmHg, RPP 33,688 ± 1,910 vs. 23,541 ± 3,858 beats·min−1·mmHg−1, −dP/d tmax−3,036 ± 247 vs. −2,091 ± 389 mmHg/s; P < 0.0001). The impairment of cardiac function was associated with myocarditis and coronary arteriolar medial thickening. Similarly depressed ventricular function and inflammatory infiltration was seen in 12 rats 7 days after MCT administration. Our findings appear unrelated to the degree of PH and indicate a direct cardiotoxic effect of MCT.
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Wu, Xianfu, Xiaoming Gong, Heather D. Foley, Matthias J. Schnell, and Zhen F. Fu. "Both Viral Transcription and Replication Are Reduced when the Rabies Virus Nucleoprotein Is Not Phosphorylated." Journal of Virology 76, no. 9 (May 1, 2002): 4153–61. http://dx.doi.org/10.1128/jvi.76.9.4153-4161.2002.
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ABSTRACT Rabies virus nucleoprotein (N) plays vital roles in regulation of viral RNA transcription and replication by encapsidation of the nascent genomic RNA. Rabies virus N is phosphorylated, and previous studies demonstrated that mutation of the phosphorylated serine at position 389 to alanine resulted in reduction of viral transcription and/or replication of a rabies virus minigenome. In the present study, we mutated the serine (S) at position 389 to alanine (A), glycine (G), aspartic acid (D), asparagine (N), glutamic acid (E), and glutamine (Q) and examined the effects of these mutations on rabies virus transcription and replication in the minigenome. Furthermore, mutations from S to A, S to D, and S to E were also incorporated into the full-length infectious virus. Mutation of the serine to each of the other amino acids resulted in the synthesis of an unphosphorylated N and reduction of viral transcription and replication in the minigenome. Mutations from S to A and S to D also resulted in reduction of both viral transcription and replication in full-length infectious viruses. Growth curve studies indicated that production of the mutant virus with the S-to-A mutation (L16A) was as much as 10,000-fold less than that of the wild-type virus (L16). Northern blot hybridization with rabies virus gene probes revealed that the rates of viral transcription and replication were reduced by as much as 10-fold in the mutant viruses when the N was not phosphorylated. Interpretation of the data from the minigenome system and the full-length infectious virus indicates that phosphorylation of rabies virus N is necessary for replication. Further studies involving cycloheximide treatment of infected cells revealed that viral transcription was also reduced when the N was not phosphorylated. Taken together, these results provide definitive evidence that N phosphorylation plays an important role in the processes of rabies virus transcription and replication.
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Gilbert, Richard D. "Carbon disulphide in organic chemistry, by A. D. Dunn and W.-D. Rudorf, John Wiley & Sons, New York, 1989, 389 pp. Price: $89.95." Journal of Polymer Science Part C: Polymer Letters 28, no. 13 (December 1990): 447. http://dx.doi.org/10.1002/pol.1990.140281308.
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van Ballegooijen, Adriana, Joline Beulens, Leon Schurgers, Elisa de Koning, Paul Lips, Natasja van Schoor, and Marc Vervloet. "Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults." Nutrients 11, no. 2 (January 22, 2019): 231. http://dx.doi.org/10.3390/nu11020231.
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Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D3 per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60–80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (n = 65 placebo vs. n = 66 vitamin D supplementation). We measured dephosphorylated uncarboxylated matrix gla protein (MGP) (dp-ucMGP) concentrations—a marker of vitamin K deficiency. Mean age was 68 years, and 89 participants (68%) were women. Vitamin K antagonists were used by 16 participants and multivitamin supplements by 50 participants. No differences in change between intervention and placebo were found (−38.5 ± 389 vs. 4.5 ± 127 (pmol/L), p = 0.562). When excluding vitamin K antagonist users and multivitamin users, dp-ucMGP at follow-up was significantly higher in the vitamin D group (n = 40) compared to placebo (n = 30), with a difference of 92.8 (5.7, 180) pmol/L, adjusting for baseline dp-ucMGP and sex. In conclusion, vitamin D supplementation for six months did not affect vitamin K status; however, among participants without vitamin K antagonist or multivitamin use, vitamin D supplementation influenced dp-ucMGP concentrations.
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Venkatachalam, Sampath Kumar, and SARAVANAM KARTHIKEYAN. "Notes on nomenclature and distribution of some taxa of Piper L. (Piperaceae)." Phytotaxa 167, no. 2 (May 9, 2014): 209. http://dx.doi.org/10.11646/phytotaxa.167.2.9.
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The species Piper petiolatum de Candolle (1866: 161) was first described based on specimens collected by J. D. Hooker and T. Thomson from Khasia hills and by W. Griffith (Kew Distribution numbers 4405 & 4410, these numbers were assigned in 1860’s at Kew before distributing the specimens to different herbaria) from East Bengal (present day Bangladesh – however, the labels on the sheets reveal that the Griffith specimens were actually collected from NE India, which is discussed below). Three years later, in A.P. de Candolle’s Prodromus, A.C.P. de Candolle cited these specimens under Chavica petiolata de Candolle (1869: 389), but did not mention his earlier publication of Piper petiolatum nor was the name listed it in the ‘Species e Pipere exclusae’. Eventually, Hooker in Flora of British India (1886: 84) also overlooked that this species name was already published under Piper Linnaeus (1753: 28) by A.C.P. de Candolle and transferred Chavica petiolata to Piper and cited his name as the author made the new combination. However, Hooker observed that the Khasian specimens quoted by A.C.P. de Candolle were actually of Piper thomsonii (de Candolle 1869: 389) Hooker (1886: 87), which was described along with Chavica petiolata. The former species is often treated as a synonym of Piper sylvaticum Roxburgh (1820: 158) (e. g. Long, 1984), although as stated by Gilbert and Nianhe (1999) certain discrepancies exist.
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Tao, Y. P., T. P. Misko, A. C. Howlett, and C. Klein. "Nitric oxide, an endogenous regulator of Dictyostelium discoideum differentiation." Development 124, no. 18 (September 15, 1997): 3587–95. http://dx.doi.org/10.1242/dev.124.18.3587.
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We have previously demonstrated that nitric oxide (NO)-generating compounds inhibit D. discoideum differentiation by preventing the initiation of cAMP pulses (Tao, Y., Howlett, A. and Klein, C. (1996) Cell. Signal. 8, 37–43). In the present study, we demonstrate that cells produce NO at a relatively constant rate during the initial phase of their developmental cycle. The addition of oxyhemoglobin, an NO scavenger, stimulates cell aggregation, suggesting that NO has a negative effect on the development of aggregation competence. Starvation of cells in the presence of glucose, which has been shown to prevent the initiation of cAMP pulses (Darmon, M. and Klein, C. (1978) Dev. Biol. 63, 377–389), results in an increased production of NO. The inhibition of cell aggregation by glucose treatment can be reversed by oxyhemoglobin. These findings indicate that NO is a signaling molecule for D. discoideum cells and that physiological or environmental conditions that enhance external NO levels will delay the initiation of cAMP pulses, which are essential for cell differentiation.
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Kwadha, Charles A., Louis A. Okwaro, Isabella Kleman, Guillermo Rehermann, Santosh Revadi, Shepard Ndlela, Fathiya M. Khamis, et al. "Detection of the spotted wing drosophila, Drosophila suzukii, in continental sub-Saharan Africa." Journal of Pest Science 94, no. 2 (January 23, 2021): 251–59. http://dx.doi.org/10.1007/s10340-021-01330-1.
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AbstractThe spotted wing drosophila, Drosophila suzukii Matsumura, is an insect pest of soft-skinned fruit, native to Eastern Asia. Since 2008, a world-wide dispersal of D. suzukii is seen, characterized by the establishment of the pest in many Asian, American and European countries. While the potential for invasion of continental Africa by D. suzukii has been predicted, its presence has only been shown for Morocco in Northern Africa. Knowledge about a possible establishment in other parts of the continent is needed as a basis for pest management. In 2019, we carried out a first survey in three counties in Kenya to monitor for the presence of D. suzukii using traps baited with a blend of apple cider vinegar and red wine. A total of 389 D. suzukii flies were captured in a fruit farm at Nakuru county, with more female flies being trapped than males. We confirmed the morphological identification of D. suzukii using DNA barcoding. In 2020, we performed a follow-up survey at 14 locations in six counties to delimit the distribution of D. suzukii in the main berry growing zones in Kenya. The survey indicated that so far D. suzukii is restricted to Nakuru county where it was initially detected. This is the first study to provide empirical evidence of D. suzukii in continental sub-Saharan Africa, confirming that the pest is expanding its geographic range intercontinentally. Given the high dispersal potential of D. suzukii, a concerted effort to develop management strategies is a necessity for containment of the pest.
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Montani, Eugenia, Candelaria Cordini, Marcelo Romano, Germán Saigo, Marcelo Janik, and Ignacio Barberis. "Nidificación de Callonetta leucophrys y Dendrocygna autumnalis en cajas nido en Corrientes, Argentina." El Hornero 34, no. 1 (March 8, 2023): 7–16. http://dx.doi.org/10.56178/eh.v34i1.468.
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En Argentina, el Pato de Collar (Callonetta leucophrys) y el Sirirí Vientre Negro (Dendrocygna autumnalis) son especies abundantes, pero poco estudiadas. Para describir la distribución estacional de las nidificaciones, el número de huevos/postura y los huevos de estas especies, se trabajó durante seis temporadas reproductivas con cajas nido dispuestas en numerosos humedales del sudoeste de la provincia de Corrientes. Se registraron 389 nidificaciones de C. leucophrys y 979 nidificaciones de D. autumnalis. El pico de nidificación de C. leucophrys ocurrió en octubre-noviembre y el de D. autumnalis en enero-febrero. El tamaño de la postura de C. leucophrys fue menor que el de D. autumnalis (mediana: 10 y 14 huevos, respectivamente). El interior de las cajas nido ocupadas por C. leucophrys fue recubierto con plumón, mientras que D. autumnalis no utilizó ningún material extra para recubrirlo. Once hembras de C. leucophrys fueron recapturadas en sucesivas temporadas, en los mismos humedales e incluso en los mismos nidos en los que habían sido anilladas. Las hembras recapturadas de D. autumnalis no regresaron al mismo nido. Los huevos de C. leucophrys fueron más pequeños que los de D. autumnalis (largo: 46.19 ± 1.79 mm vs. 50.76 ± 1.95 mm; ancho: 34.04 ± 1.14 mm vs. 37.65 ± 1.19 mm; peso: 27.68 ± 2.89 g vs. 38.65 ± 3.73 g, respectivamente). Estos resultados demuestran la utilidad de las cajas nido como herramienta para aumentar el conocimiento de la biología reproductiva de patos que nidifican en cavidades.
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Boltz, Marie, Jacqueline Mogle, and Ashley Kuzmik. "PATIENT AND FAMILY PARTNER OUTCOMES OF THE FAM-FFC TRIAL." Innovation in Aging 7, Supplement_1 (December 1, 2023): 93. http://dx.doi.org/10.1093/geroni/igad104.0301.
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Abstract The Fam-FFC trial tested the hypotheses that patients who participated in Fam-FFC would have more return to baseline function, more physical activity, and less delirium, depressive symptoms, and behavioral symptoms of distress, and that care partners would demonstrate increased preparedness for caregiving (primary outcome) and less anxiety, strain, and burden, as compared to participants in the control arm. The likelihood of returning to baseline function across time for Fam-FFC participants was twice that of the control group by the end of 6 months (OR = 2.39, p =.011). Fam-FFC was also associated with fewer behavioral symptoms of distress at six-months (changeintervention = -1.973, SE = .396, p < .0001, d = .467; changecontrol = -.859, SE = .389, p = .028, d = .203); moderate physical activity, depressive symptoms, and delirium severity did not differ by treatment arm. Preparedness for caregiving increased significantly more from 2 months to 6-months (changeintervention=2.4, SE=.439, d=.563; changecontrol=.893, SE=.450, d=.212, overall p = .02), and marginally increased from discharge to six months. (changeintervention= 2.783, SE= 0.44, d=.682; changecontrol=1.695, SE=0.44, d=0.415, overall p =0.08), in the intervention group, with no group differences in anxiety, strain, and burden. Fam-FFC may prevent some of the post-acute functional decline and behavioral symptoms in persons with dementia while increasing FCP preparedness. Future research should focus on sustainability of patient improvements and addressing the chronic stressors associated with the care partner role.
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Neal, G. E. "D. H. Hutson, J. Caldwell and G. D. Paulson (eds) Intermediary Xenobiotic Medicine in Animals. Methodology, Mechanisms and Significance Taylor & Francis, London, 1989; 389 pp." Journal of Applied Toxicology 11, no. 1 (February 1991): 77. http://dx.doi.org/10.1002/jat.2550110114.
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Caddick, Mark X., and Herbert N. Arst. "Deletion of the 389 N-Terminal Residues of the Transcriptional Activator AREA Does Not Result in Nitrogen Metabolite Derepression in Aspergillus nidulans." Journal of Bacteriology 180, no. 21 (November 1, 1998): 5762–64. http://dx.doi.org/10.1128/jb.180.21.5762-5764.1998.
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ABSTRACT Utilizing a homologous gene replacement in order to retain the native promoter and 5′ and 3′ untranslated messenger regions (and thereby ensure physiological validity), we have shown that deletion of the N-terminal 389 amino acids of the transcriptional activator AREA does not result in nitrogen metabolite derepression inAspergillus nidulans. Our results provide no evidence for a modulating interaction involving the N terminus of AREA and contrast with those of H. K. Lamb, A. L. Dodds, D. R. Swatman, E. Cairns, and A. R. Hawkins (J. Bacteriol. 179:6649–6656, 1997), who used nontargeted ectopic copies of a construct containing a heterologous promoter and untranslated regions. Results obtained with this deletion mutant, nevertheless, provide further evidence for the dispensability of large portions of AREA.
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Garbacz, Piotr, David Håkansson, and Henrik Rosenkvist. "John D. Sundquist. Morphosyntactic Change in the History of the Mainland Scandinavian Languages. Ann Arbor, MI: ProQuest, 2002, 389 pp." Nordic Journal of Linguistics 30, no. 1 (May 14, 2007): 137–46. http://dx.doi.org/10.1017/s0332586507001680.
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Sulaiman, Rizgar Rahim, Hardi Fattah Marif, Basim Abdulwahid Ali, Kwestan Najm Ali, and Muhamad Omer Baba Shekh. "Genetic Variability and Antibacterial Sensitivity of Dichelobacter nodosus and Fusobacterium necrophorum Infection in Sheep Sulaimani Province, Kurdistan Region, Iraq." Iraqi Journal of Veterinary Medicine 48, no. 1 (June 28, 2024): 93–100. http://dx.doi.org/10.30539/xxn4db22.
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Footrot is a significant health problem in ruminants, especially sheep, caused by the bacteria Dichelobacter nodosus and Fusobacterium necrophorum. Infected animals may become lame and lose body condition. The aim of this study was to investigate whether sheep had mixed infections with D. nodosus and F. necrophorum, the global genetic relationships of both target genes (lktA and 16S rRNA genes) with different reference genes, and the degree of genetic heterogeneity between the standard serogroups of D. nodosus were studied. In addition, to detect the antibacterial sensitivity against these two pathogens. One hundred and seventy-five sheep interdigital spaces were investigated (2016-2022). The D. nodosus field isolate (Dn Sul/016-KY399851) showed 96% compatibility with other global isolates (NR_104942/USA, JN008724/India, and DQ016290/Sweden) when its 16S rRNA sequence was compared to some reference genes. The local isolate (Fn Sul/016- KY399852) and other IktA gene strains from other nations (FJ230831/New Zealand, JX678872/Australia, JX648295/India) were compared, and the results showed 99% and 96% identity. Additionally, within the multiple sequence alignment, a single nucleotide variation at position 389 (CA) was seen in the partial lktA sequence when compared to the field isolate (Fn Sul/16-KY399852). This modification corresponds to a switch at residue 130 from alanine (Ala) to glutamic acid (Glu). This study showed the initial molecular identification of D. nodosus and F. necrophorum from sheep with footrot in the Iraqi province of Sulaimani.
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Singh, Khushwant, and Jiban Kumar Kundu. "Variations in coat protein sequence of Wheat streak mosaic virus among crop and non-crop hosts." Crop and Pasture Science 68, no. 4 (2017): 328. http://dx.doi.org/10.1071/cp17025.
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Wheat streak mosaic virus (WSMV) has become a re-emerging pathogen in recent years in the Czech Republic. Crop (e.g. wheat, barley, maize) and non-crop grasses from the Poaceae family are the natural hosts of the virus. Here, we report the results from coat protein (CP) gene-sequence analysis of WSMV isolates from wheat crops (four cultivars: Turondot, Bodyček, Avenue, Hymack) and three grass species (Agropyron repens, Phleum pratense, Poa pratensis). Phylogenetic reconstruction of putative CP sequences showed that all tested isolates clustered with existing type B isolates of WSMV (originating from Europe and Asia) rather than type D (originating from USA, Argentina, Australia, and Iran) and type A (originating from Mexico) isolates. Analysis of recombination events showed that Turondot and Hymack isolates recombined with P. pratense, whereas Bodyček and Avenue isolates recombined with a type B isolate (Iran_Saadat-Shahr). The grasses A. repens, P. pratense and P. pratensis share recombination events with type A (Mexico_El Batán), type B (French and German isolates) and type D (Iran_Naghadeh) isolates. The characteristic GCA (Gly276) triplet codon found in type B isolates was conserved in both the wheat and grass isolates. Notably, nucleotide variations were mainly observed at positions nt 381–389, nt 405–460 and nt 486–497 between crop and non-crop hosts. Based on our analysis, we propose that the grass isolates form subtype B1 within the type B isolates of WSMV. Putative CP amino acid sequences in the centre of the protein and in the C-terminal domain (aa 112–260) were significantly more frequently conserved in both wheat and grasses than those in the N-terminal domain (aa 11–80). Collectively, these results indicate that variations exist between crop and non-crop hosts of WSMV.
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Ennabili, Abdeslam, and Mohammed Ater. "Flore (Pteridophyta et Spermatophyta) des zones humides du Maroc Méditérranéen: Inventaire et écologie." Acta Botanica Malacitana 21 (December 1, 1996): 221–39. http://dx.doi.org/10.24310/abm.v21i0.8677.
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Malgré l'intéret qu' on porte de plus en plus aux zones humides á travers le monde, peu d' etudes ont été consacrées á la flore hygrophile marocaine. Aprés avoir prospecté 45 stations, on a évalué la diversité spécifique des hygrophytes du Maroc méditerranéen á partir de 70 relevés floristiques. Sur les 389 espéces reconnues dans cette etude, 175 especes sont caractéristiques des zones humides. Les espéces rares ou nouvellement citées ont été soulignées. D'autre part, les phytocenoses observées ant été classées en fonction de la physionomie et de la composition spécifique. Une attention particuliere a été consacrée á la discussion des principaux facteurs écologiques influant sur les groupements hygrophiles á savoir : la submersion, la salinité, la charge organique domestique, le mésoclimat et les travaux d'aménagement. Ainsi, on a pu regrouper les espéces dominantes en classes écologiques.
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Juraschek, Stephen P., Xiaoming Zhang, Vinoth Ranganathan, and Vernon W. Lin. "United States Registered Nurse Workforce Report Card and Shortage Forecast." American Journal of Medical Quality 27, no. 3 (November 19, 2011): 241–49. http://dx.doi.org/10.1177/1062860611416634.
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Registered nurses (RNs) play a critical role in health care delivery. With an aging US population, health care demand is growing at an unprecedented pace. Using projected changes in population size and age, the authors developed demand and supply models to forecast the RN job shortage in each of the 50 states. Letter grades were assigned based on projected RN job shortage ratios. The number of states receiving a grade of “D” or “F” for their RN shortage ratio will increase from 5 in 2009 to 30 by 2030, for a total national deficit of 918 232 (725 619 - 1 112 112) RN jobs. There will be significant RN workforce shortages throughout the country in 2030; the western region will have the largest shortage ratio of 389 RN jobs per 100 000. Increased efforts to understand shortage dynamics are warranted.
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Juraschek, Stephen P., Xiaoming Zhang, Vinoth Ranganathan, and Vernon W. Lin. "Republished: United States Registered Nurse Workforce Report Card and Shortage Forecast." American Journal of Medical Quality 34, no. 5 (September 2019): 473–81. http://dx.doi.org/10.1177/1062860619873217.
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Registered nurses (RNs) play a critical role in health care delivery. With an aging US population, health care demand is growing at an unprecedented pace. Using projected changes in population size and age, the authors developed demand and supply models to forecast the RN job shortage in each of the 50 states. Letter grades were assigned based on projected RN job shortage ratios. The number of states receiving a grade of “D” or “F” for their RN shortage ratio will increase from 5 in 2009 to 30 by 2030, for a total national deficit of 918 232 (725 619 - 1 112 112) RN jobs. There will be significant RN workforce shortages throughout the country in 2030; the western region will have the largest shortage ratio of 389 RN jobs per 100 000. Increased efforts to understand shortage dynamics are warranted.
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Holland, R. F. "Rush Rhees on Religion and Philosophy D. Z. Phillips (ed.) Cambridge University Press, 1997, pp. xii + 389, £50 (US $69.95) Hb." Philosophy 73, no. 3 (July 1998): 495–523. http://dx.doi.org/10.1017/s0031819198230105.
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Slayton, Mark D., Zackariah A. Farah, Jin Heon Jeon, Abhinav Achreja, Ben Krinkel, Brisilda Nilaj, Yi-Hsien Eu, et al. "Abstract 431: Malic enzyme 2 inhibition reveals metabolic vulnerability in serine-dependent triple-negative breast cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 431. http://dx.doi.org/10.1158/1538-7445.am2024-431.
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Abstract Background & Hypothesis: Treatments for triple-negative breast cancer (TNBC) are limited to chemotherapy, PARP inhibitors and immunotherapies. Tumor metabolism seeks to identify metabolic pathways preferentially utilized by cancer. Malic enzyme 2 (ME2) has a role in the malate-aspartate shuttle and pyruvate and NADPH production, contributing to the redox balance and metabolite synthesis. We demonstrated that ME2 knockdown inhibits growth of TNBC cells with upregulated serine biosynthesis pathway. We hypothesized that ME2 knock-down (kd) would be growth inhibitory in vivo. Methods: We used a non-tumorigenic control (MCF10a) and TNBC lines (BT20, MDA-MB-468, HCC1806, HCC70, Hs578T, SUM149). Nude mice received mammary fat pad xenografts of MDA-MB-468, to assess the impact of ME2-shRNA on growth. ME2 relevant metabolite profiling was achieved through the Promega Metabolite-Glo assay, measuring NAD, NADH, NADP, NADPH, Malate, and Glutamate. Cellular proliferation was quantified via the BioTek BioSpa 8 system and Promega CellTiter Glo. Comprehensive profiling of metabolic genes was achieved with the Nanostring nCounter across all cell lines. The potential therapeutic efficacy of NPD-389, MDSA, disodium embonate and doxorubicin was evaluated, alone or in combination, through targeted drug assays. Metabolic flux analyses, specifically mitochondrial and glycolytic function, were conducted using the Seahorse XF96, contrasting ME2-shRNA modified and control cells. Results: ME2 kd resulted in reduced proliferation in several TNBC cell lines to varying degrees, in contrast to control MCF10a, and to Hs578T. In response to the loss of ME2, several cell lines upregulated serine biosynthesis genes, including PSAT1. MDA-MB-468 ME2 kd cells developed significantly smaller tumors in a nude mouse xenograft model. Increased malate levels, but reduced NADH and NADPH, were detected in TNBC cells with inhibited growth post-ME2 kd, but not in MCF10a or Hs578T cells. Among the tested ME2 inhibitors, NPD-389 had superior efficacy vs. MDSA and disodium embonate. Metabolic flux analysis showed compromised mitochondrial and glycolytic processes in the TNBC cell lines exhibiting growth inhibition upon ME2 kd. Conclusions: ME2 knockdown selectively impairs cell proliferation and tumor growth in TNBC cell lines, validating its potential as a therapeutic target. The differential metabolic response, including altered malate and NADH/NADPH levels, confirms ME2's importance in TNBC metabolism. NPD-389 effectively reduced growth in ME2-sensitive lines, meriting further investigation. These findings support targeting ME2 in as a novel treatment strategy. Citation Format: Mark D. Slayton, Zackariah A. Farah, Jin Heon Jeon, Abhinav Achreja, Ben Krinkel, Brisilda Nilaj, Yi-Hsien Eu, Justin Sung, Alyssa Rosenfeld, Alisa Lui, Mason Collard, Liwei Bao, Xu Cheng, Celina Kleer, Kerry Loomes, Deepak Nagrath, Sofia D. Merajver. Malic enzyme 2 inhibition reveals metabolic vulnerability in serine-dependent triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 431.
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Carvalho, Victor V., Alexandre Perdigão, Tiago S. Acedo, Guilherme S. Vasconcellos, and Luis Fernando Tamassia. "391 Effects of increasing carbohydrases levels on productive performance of beef cattle fed feedlot finishing diets." Journal of Animal Science 97, Supplement_3 (December 2019): 155. http://dx.doi.org/10.1093/jas/skz258.318.
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Abstract Our objective was to evaluate the effects of feeding increasing exogenous carbohydrases levels on cattleˈ performance, when fed a 90-d feedlot finishing diet. A total of 240 Nellore bulls (IBW = 389 ± 27 kg) were distributed in 24 pens (10 animals/pen), in a randomized complete block design (6 pens/treatment). The basal diet was composed by 15% sugarcane bagasse, 72.8% ground corn, 7.6% soybean meal and 4.6 % mineral-vitamin premix (DM basis). The treatments were: 1) control: No addition of carbohydrases blend; 2) Blend1, in g/animal/d: 1 g of Ronozyme® WX (xylanase) + 3.75 g of Ronzyme® VP (beta-glucanase); 3) Blend2, in g/animal/d: 2 g of Ronozyme® WX + 7.5 g of Ronzyme® VP and 4) Blend3, in g/animal/d: 4 g of Ronozyme® WX + 15 g of Ronzyme® VP. The animals were fed once a day and had free access to fresh water. Statistical analysis was performed using the MIXED procedure of SAS 9.4, and comparisons were performed out by orthogonal contrasts, which compared the control and treatments, and the linear and quadratic effects of the increasing carbohydrases levels. Statistical significance was declared at P < 0.05, and tendencies considered when 0.05 < P < 0.10. Animals fed carbohydrases had greater (P = 0.045) ADG (1.59 vs. 1.51 kg/d) and tended to have greater (P = 0.069) final BW (533.4 vs. 527.7 kg) compared with control; although no difference were observed on these variables among carbohydrases levels. Feeding carbohydrases increased DM intake, expressed either as kg/d (10.17 vs. 9.92; P = 0.019) and as percentage of BW (2.20 vs. 2.16 %; P = 0.038), compared to control group, respectively. However, no difference was observed among treatments on G:F, and dressing percentage. In conclusion, the addition of carbohydrases blend can improve performance of finishing cattle.
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Yang, Sophie Xin, Siyu Cheng, Yuanfeng Sun, Xiangdong Tang, and Zhijiao Huang. "Circadian Disruption in Civilian Airline Pilots." Aerospace Medicine and Human Performance 95, no. 7 (July 1, 2024): 381–89. http://dx.doi.org/10.3357/amhp.6316.2024.
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INTRODUCTION: Most airline pilots reported having suffered from sleep disorders and fatigue due to circadian disruption, a potential risk to flight safety. This study attempted to uncover the actual scenario of circadian disruption and working load status among airline pilots.METHODS: In study 1, 21 pilots were invited to participate in a 14-d sleep monitoring and a dual 2-back test to monitor their sleep patterns and cognitive function level. To provide an in-depth view, data from scheduled flights, including 567 airline pilots, was analyzed in Study 2. The present study used cluster analysis to reflect the distribution of the flight scheduling characteristics, including working time and actual working hours. A simulation model was then developed to predict the pilots’ 1-mo sleep-wake pattern.RESULTS: The results indicated that sleep problems were prevalent in this population, especially the night before an earlier morning shift. Regarding the cognitive test, they scored the lowest on earlier morning shifts compared with daytime and evening shifts. It was found that over 70% of the flight schedules can lead to circadian disruption, and 47.44% of the pilots worked under high-load status.DISCUSSION: Airline pilots inevitably work irregular hours and the current policies for coping with circadian disruption seem inefficient. This study thus calls for urgency in improving scheduling and fatigue management systems from the circadian rhythm perspective.Yang SX, Cheng S, Sun Y, Tang X, Huang Z. Circadian disruption in civilian airline pilots. Aerosp Med Hum Perform. 2024; 95(7):381–389.
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Liu, Shuo, Yuguo Wu, Chunshan Zhou, Jianming Wu, and Yulong Zhang. "Study on the CO Formation Mechanism during Coal Ambient Temperature Oxidation." Energies 13, no. 10 (May 20, 2020): 2587. http://dx.doi.org/10.3390/en13102587.
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The CO formation rules of coal were analyzed by a self-developed testing device under ambient temperature. The changes of functional groups caused by oxidation were obtained using Fourier-transform infrared spectroscopy (FTIR). The experimental results showed that CO was generated during the ambient temperature oxidation. The highest concentration level of CO could be 389 ppm. The methylene and aldehyde groups on the side chains were involved in the reaction. For the quantum mechanical approach, we employed the density functional theory with the 6–31 G (d, p) basis set. Density functional theory–based computations interpreted the possible reaction sites on a coal molecule by electronic static potential analysis. The rationality of the predicted reactions was also evaluated by transition state analysis and energy analysis. This research theoretically proved that coal could be oxidized to carbon monoxide under ambient temperatures and gave the possible reaction paths.
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Díaz Morales, Juan Francisco, and Patricia Martínez. "Metas y satisfacción vital en adolescentes españoles y peruanos según sexo y nivel socioeconómico." Revista de Psicología 22, no. 1 (July 29, 2004): 121–49. http://dx.doi.org/10.18800/psico.200401.006.
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El presente estudio analiza el tipo de metas personales y la satisfacción vital en adolescentes españoles y peruanos según sexo y nivel socioeconómico. Se trabajó con 389 adolescentes españoles y con 285 peruanos, de ambos sexos y de diferentes niveles socioeconómicos. Los instrumentos utilizados fueron el Análisis de Metas Personales de Palys y Little (1983) y la Escala D-T (Delight-Terrible) de Andrews y Withey (1976) para la muestra española, y el Método de Inducción Motivacional de Nuttin (1985) junto con la Escala de Satisfacción con la vida de Pavot y Diener (1993) para la muestra peruana, que aunque no son equivalentes, permiten una comparación general. Los resultados muestran importantes semejanzas en las metas descritas por los adolescentes de ambos estudios, así como en la influencia de la variable sexo. Las principales diferencias entre los adolescentes españoles y peruanos se encuentran en la variable nivel socioeconómico.
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Lenka, Krpalkova, Cabrera Victor E, Kvapilik Jindrich, and Burdych Jiri. "Associations of reproduction and health with the performance and profit of dairy cows." Agricultural Economics (Zemědělská ekonomika) 62, No. 8 (July 15, 2016): 385–94. http://dx.doi.org/10.17221/176/2015-agricecon.
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The objective of the study was to evaluate the associations of the variable intensity in culling of dairy cows and culling due to the movement disorders, mammary gland diseases, long calving interval, low fertility and postpartum complications with production, reproduction and economic parameters on 60 commercial dairy herds. The data encompassed 34 632 cow records from the Czech Republic 12 regions and were collected during a 1-yr period (2012). The milk yield during the production period was analysed relative to the reproduction and economic parameters. The main reasons for culling cows were fertility problems and movement disorders, followed by the low milk yield, mammary gland diseases, and postpartum complications. The analysis of fertility showed that the herds with the longest calving intervals (≥ 410 d) and the highest culling due to fertility (≥ 25% of the total) achieved the lowest milk yields. The average difference between the highest and lowest calving interval (≤ 389 d) groups was 721 kg/cow per yr. The lowest reported profitability of costs was for the longest calving interval and the highest postpartum complications groups. Although the reproductive performance directly affects the dairy farm profitability, the dairy cows’ production potential should be considered when making culling decisions in order to achieve the most profitable management strategy.
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Jones, Jessica M., Carrie Simkus, and Anamika Bhattacharyya. "KPNA1 is a putative substrate of the RAG1 ubiquitin ligase (138.11)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 138.11. http://dx.doi.org/10.4049/jimmunol.182.supp.138.11.
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Abstract The RAG1 V(D)J recombinase encompasses DNA binding/cleavage and ubiquitin ligase activities. The nuclear transport protein karyopherin alpha 1 (KPNA1) binds to RAG1 upstream of its ubiquitin ligase domain, but this interaction is not required for nuclear localization of RAG1. We found that the isolated ubiquitin ligase domain of RAG1 (amino acids 218-389) promoted ubiquitylation of purified KPNA1 in a reaction supported by the ubiquitin conjugating (E2) enzyme UbcH2/Rad6 or UbcH5a. KPNA1 is the first putative substrate identified for the RAG1 ubiquitin ligase. Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1. RAG1 did not promote rapid ubiquitin chain extension following mono-ubiquitylation of substrate, regardless of the E2 used. Substitutions of amino acids surrounding the third, non-canonical Zn coordination site of the RAG1 RING domain abrogated functional interaction with E2 enzymes, and this was significantly correlated with reduction in the ability of full length RAG1 to support recombination of extra-chromosomal substrates. These data suggest that RAG1-dependent mono-ubiquitylation of a substrate, possibly KPNA1, is required for optimal levels of V(D)J recombination.
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Krpálková, Lenka. "Analysis of milk production, age at first calving, calving interval and economic parameters in dairy cattle management." Mljekarstvo 67 (February 1, 2017): 58–70. http://dx.doi.org/10.15567/mljekarstvo.2017.0107.
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The objective of this study was to evaluate main indicators of milk production on total 60 commercial dairy herds from the Czech Republic during a 9-yr period (2006-2014). Breakeven points and sensitivity analysis were used and associations of age at first calving (AFC), milk yield (MY) and calving interval (CI) were analyzed. Lowest AFC≤749 d showed the highest fertility, the lowest death rate of calves and lowest profitability without subsidies -2.49 %. Highest MY≥9,000 kg showed the highest fertility, lowest AFC, lowest feed costs and total costs 8.58 CZK (0.32 EUR) per L of milk and subsequent highest profitability 2.37 %. The analysis of fertility showed that herds with the lowest CI (≤389 d) achieved lowest cow depreciation costs 0.71 CZK (0.03 EUR) per L of milk, highest total costs 9.72 CZK (0.36 EUR) per L of milk and highest profitability 1.29 %. Breakeven points for the price of milk ranged between 7.81 and 8.75 CZK (0.29 and 0.32 EUR) per L in yr 2007 and 2014. Increase in input prices should adversely affect the increase the price of milk. The increase of price of milk by 1 % in 2014 will cause an increase in profit of CZK 745 (27.6 EUR) per cow per year.
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Panknin, Timothy M., Carol L. Howe, Meg Hauer, Bhanu Bucchireddigari, Anthony M. Rossi, and Janet L. Funk. "Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials." International Journal of Molecular Sciences 24, no. 5 (February 24, 2023): 4476. http://dx.doi.org/10.3390/ijms24054476.
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Medicinal properties of turmeric (Curcuma longa L.), a plant used for centuries as an anti-inflammatory, are attributed to its polyphenolic curcuminoids, where curcumin predominates. Although “curcumin” supplements are a top-selling botanical with promising pre-clinical effects, questions remain regarding biological activity in humans. To address this, a scoping review was conducted to assess human clinical trials reporting oral curcumin effects on disease outcomes. Eight databases were searched using established guidelines, yielding 389 citations (from 9528 initial) that met inclusion criteria. Half focused on obesity-associated metabolic disorders (29%) or musculoskeletal disorders (17%), where inflammation is a key driver, and beneficial effects on clinical outcomes and/or biomarkers were reported for most citations (75%) in studies that were primarily double-blind, randomized, and placebo-controlled trials (77%, D-RCT). Citations for the next most studied disease categories (neurocognitive [11%] or gastrointestinal disorders [10%], or cancer [9%]), were far fewer in number and yielded mixed results depending on study quality and condition studied. Although additional research is needed, including systematic evaluation of diverse curcumin formulations and doses in larger D-RCT studies, the preponderance of current evidence for several highly studied diseases (e.g., metabolic syndrome, osteoarthritis), which are also clinically common, are suggestive of clinical benefits.
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Zhang, Liqun, Zhuo Wang, Jiawen Xiao, Zhiyan Zhang, Haijing Li, Fang Li, Lisha Zhang, and Yuanhe Wang. "Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer." Journal of Oncology 2021 (June 21, 2021): 1–11. http://dx.doi.org/10.1155/2021/9973743.
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Gastric cancer (GC) is one of the most common malignancies worldwide. Notably, patients with advanced GC have a poor prognosis and quality of life, prompting the need for further studies on its prognostic markers. Among these, albumin and D-dimer are often used as prognostic factors in the prediction of a variety of tumors. Moreover, the albumin to D-dimer ratio (ADR) may be an improved predictor of chemotherapy effect and survival compared to albumin and D-dimer alone, but few studies have investigated this issue. Thus, we explored the relationship between pretreatment ADR and prognosis in advanced GC treated with first-line chemotherapy. A total of 247 advanced unresectable GC patients treated with first-line chemotherapy were retrospectively included. The cut-off value for ADR was determined using the receiver operating characteristic (ROC) curve. The ADR had a cut-off value of 41.64. Compared to albumin and D-dimer alone, ADR had the highest area under curve (AUC) value (AUC = 0.730), followed by albumin (AUC = 0.659) and D-dimer (AUC = 0.719). Additionally, we found that patients with a low ADR (<41.64) had a lower disease control rate (77.9% vs. 92.5%, P < 0.01 ), shorter overall survival (OS) (271 vs. 389 days), and shorter progression-free survival (PFS) (118 vs. 192 days) than patients with a high ADR (≥41.64). Similar results were also found on subgroup analysis, and ADR was found to be an independent advanced GC prognostic factor on multivariate analysis (all P < 0.001 ). Low ADR was found to be correlated with poor therapeutic effects of chemotherapy and shortened OS and PFS. Therefore, pretreatment ADR may be a useful tool for predicting the effect of chemotherapy and prognosis in advanced GC patients treated with first-line chemotherapy.
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Wilkinson, Melanie. "Aboriginal Languages In Education by D. Hartman and J. Henderson (Eds), Institute for Aboriginal Development Press, Alice Springs, 1994, ii + 389 pp." Aboriginal Child at School 23, no. 3 (September 1995): 54–56. http://dx.doi.org/10.1017/s0310582200004958.
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