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Academic literature on the topic 'Cytomegalovirus infections Diagnosis'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Cytomegalovirus infections Diagnosis"

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van Zuylen, Wendy J., Stuart T. Hamilton, Zin Naing, Beverly Hall, Antonia Shand, and William D. Rawlinson. "Congenital cytomegalovirus infection: Clinical presentation, epidemiology, diagnosis and prevention." Obstetric Medicine 7, no. 4 (September 25, 2014): 140–46. http://dx.doi.org/10.1177/1753495x14552719.

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Cytomegalovirus is the most common congenital infection causing serious disease in infants. It is the leading infectious cause of sensorineural hearing loss and neurodevelopmental disability in developed countries. Despite the clinical importance of congenital cytomegalovirus, surveys show there is limited awareness and knowledge in the medical and general community about congenital cytomegalovirus infection. This article reviews the clinical features, global epidemiology, transmission and risk factors for cytomegalovirus infections. It also highlights several major advances made in recent years in the diagnosis and prevention of cytomegalovirus infection during pregnancy. Although research is ongoing, no therapy is currently proven to prevent or treat maternal, fetal or neonatal cytomegalovirus infection. Education of women regarding hygiene measures can help prevent cytomegalovirus infection and are currently the best strategy to prevent congenital cytomegalovirus disease.
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Aguado, S., E. Gómez, S. Melón, M. de Oña, A. Martínez, and J. Alvarez-Grande. "Diagnosis of Cytomegalovirus Infections." Nephron 57, no. 1 (1991): 116. http://dx.doi.org/10.1159/000186231.

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Pass, Robert F., and Ravit Arav-Boger. "Maternal and fetal cytomegalovirus infection: diagnosis, management, and prevention." F1000Research 7 (March 1, 2018): 255. http://dx.doi.org/10.12688/f1000research.12517.1.

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Congenital cytomegalovirus infection is a major cause of central nervous system and sensory impairments that affect cognition, motor function, hearing, language development, vestibular function, and vision. Although the importance of congenital cytomegalovirus infection is readily evident, the vast majority of maternal and fetal infections are not identified, even in developed countries. Multiple studies of prenatal cytomegalovirus infections have produced a body of knowledge that can inform the clinical approach to suspected or proven maternal and fetal infection. Reliable diagnosis of cytomegalovirus infection during pregnancy and accurate diagnosis of fetal infection are a reality. Approaches to preventing the transmission of cytomegalovirus from mother to fetus and to the treatment of fetal infection are being studied. There is evidence that public health approaches based on hygiene can dramatically reduce the rate of primary maternal cytomegalovirus infections during pregnancy. This review will consider the epidemiology of congenital cytomegalovirus infection, the diagnosis and management of primary infection during pregnancy, and approaches to preventing maternal infection.
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N, Singh. "Cytomegalovirus Infection in Organ Transplant Recipients: Diagnosis, Prevention and Treatment." Virology & Immunology Journal 6, no. 3 (November 4, 2022): 1–6. http://dx.doi.org/10.23880/vij-16000303.

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The most common infectious complication after first month of solid organ transplants is cytomegalovirus (CMV). Both direct such as viral syndrome, hepatitis, pneumonitis, colitis, etc. and indirect consequences such as rejection, infections by other microorganisms and graft dysfunction, are carried on by the virus. Latent infection, active infection, viral syndrome, and invasive disease are the four types of infection that can emerge due to transmission from the transplanted organ, reactivation of latent infection, or after a primary infection in seronegative individuals. Typically, this syndrome appears 30 to 90 days following transplantation. Several antiviral medications, including acyclovir, valacyclovir, ganciclovir, and valganciclovir, are being used for CMV prophylaxis and therapy. Furthermore, these antiviral medications are toxic and have serious adverse effects, including drug resistance, leukopenia, thrombocytopenia, renal failure, and neuropsychiatric symptoms. We attempted to discuss CMV risk factors, laboratory diagnosis, prevention, treatment and therapeutic in this review study with regard to organ transplantation.
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Kwok, Chun Shing, Kirellos Said Abbas, Adnan I. Qureshi, Duwarakan Satchithananda, and Josip Andelo Borovac. "The Impact of Concomitant Diagnosis of Viral Infections on in-Hospital Mortality in Patients Hospitalized with a Diagnosis of Heart Failure in the United States: Insights from the National Inpatient Sample." Viruses 14, no. 11 (October 31, 2022): 2418. http://dx.doi.org/10.3390/v14112418.

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The impact of viral infections on patients admitted with a diagnosis of heart failure is not well understood. We conducted a retrospective cohort study using data from the National Inpatient Sample in the United States to evaluate the proportion of admissions with a diagnosis of heart failure and viral infections, and we explored how viral infections had impact on in-hospital mortality and length of stay. There were a total of 20,713,539 admission records with a diagnosis of heart failure included in the analysis and 3.8% had a concomitant diagnosis of viral infection. The mean length of stay was 20.1 ± 26.9 days, 12.9 ± 13.6 days, 12.1 ± 13.8 days, and 5.1 ± 6.5 days for records with a diagnosis of cytomegalovirus, viral meningitis/encephalitis, herpes simplex infection, and no viral infection, respectively. The most common diagnoses of viral infections were influenza (n = 240,260) and chronic viral hepatitis (n = 194,400), and the highest rates of mortality were observed for records with a diagnosis of cytomegalovirus (13.2%), acute viral hepatitis (12.5%), and viral meningitis/encephalitis (11.1%). The viral infections significantly associated with increased odds of mortality were cytomegalovirus infection (OR 1.84 95% CI 1.57–2.16), acute hepatitis (OR 1.29 95% CI 1.15–1.45), and HIV (OR 1.22 95% CI 1.11–1.34). In conclusion, viral infections are co-diagnosis in 3.8% of patient records with heart failure and detection of some viruses may be important as they increase mortality and may prolong length of stay in hospital.
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Grunwald, Arkadiusz, Kinga Brzuszkiewicz, Katarzyna Nowak, Małgorzata Satora, Jakub Klas, and Gracjan Rudziński. "Cytomegalovirus infection in pregnant women - threats, diagnosis and treatment." Journal of Education, Health and Sport 12, no. 12 (November 18, 2022): 187–92. http://dx.doi.org/10.12775/jehs.2022.12.12.029.

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Cytomegalovirus is one of the most widespread DNA viruses, with 90% of women of childbearing age in Poland infected with it. Infection poses a risk to the mother as well as the fetus, as the virus can cross the placenta and damage the fetus. The purpose of this paper is to review scientific publications from 2017-2022, which describe the course of cytomegalovirus infection in pregnant women, the risks to the mother and fetus associated with the infection, methods of diagnosing the infection in the pregnant woman and the fetus, as well as treatment of cytomegalovirus infection and directions for vaccine research. The most common complications of congenital cytomegalovirus infection include hearing loss, mental developmental delays and miscarriage. The infection can be detected in the pregnant woman by immunological testing, while polymerase chain reaction is used in the fetus and newborn. Early detection of infection in a pregnant woman allows the implementation of treatment which includes ganciclovir, valganciclovir, acyclovir and valacyclovir. A vaccine against cytomegalovirus has not been developed. Particularly important in the prevention of infection is to conduct educational activities regarding the routes of transmission of the virus and the consequences of congenital infection for the fetus. Cytomegalovirus infections among pregnant women. It is important to monitor fetal development and possibly diagnose for congenital CMV infection in case of abnormalities, and the best diagnostic method is polymerase chain reaction testing. For the treatment of congenital CMV infection, acyclovir and valacyclovir are preferred, and therapy should be implemented for specific indications. Attention should be paid to educating women about infections caused by cytomegalovirus.
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Myers, J. B., and D. Amsterdam. "The laboratory diagnosis of cytomegalovirus infections." Immunological Investigations 26, no. 3 (January 1997): 383–94. http://dx.doi.org/10.3109/08820139709022694.

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Saldan, Alda, Gabriella Forner, Carlo Mengoli, Nadia Gussetti, Giorgio Palù, and Davide Abate. "Testing for Cytomegalovirus in Pregnancy." Journal of Clinical Microbiology 55, no. 3 (December 28, 2016): 693–702. http://dx.doi.org/10.1128/jcm.01868-16.

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ABSTRACT Congenital cytomegalovirus (CMV) infection represents a relevant cause of deafness and neurological damage in newborns. Intrauterine CMV transmission might result after primary or nonprimary infections, though at different rates (30% versus 0.2%, respectively). At present, a prenatal diagnosis of CMV infection is based mainly on maternal serology, the detection of CMV-DNA in amniotic fluid and fetal blood, and ultrasound (US) and magnetic resonance imaging (MRI). Recent evidences suggest that congenital CMV infection may be an immune-mediated disease and that evaluation of humoral and especially T-cell immunities may improve the overall prenatal diagnosis. This review summarizes the most recent advancements in the diagnosis of maternal and prenatal CMV infections.
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Basha, James, Jenna M. Iwasenko, and William Rawlinson. "Diagnosis of herpesviruses and approaches to difficult diagnoses." Microbiology Australia 31, no. 3 (2010): 115. http://dx.doi.org/10.1071/ma10115.

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Herpesviruses are a ubiquitous family of DNA viruses, with 40?60% of the adult population seropositive for cytomegalovirus (CMV), and more than 90% for Epstein-Barr virus (EBV) and varicella zoster virus (VZV). Following primary infection, herpesviruses become latent in the host and may reactivate during periods of immunosuppression, such as in transplant recipients, HIV-positive patients and pregnant women. The clinical course following reactivation presents a screening and diagnostic challenge, particularly as reactivation in immunosuppressed patients may have a clinical presentation consistent with many different infections. For example, CMV pneumonitis produces disease clinically consistent with other viral pneumonias such as influenza infection. It is, therefore, imperative to obtain as relevant and accurate diagnostic information to correctly diagnose herpesvirus infections.
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Grineva, A. A., V. V. Vasiliev, and N. V. Rogozina. "Management of pregnant women with congenital cytomegalovirus and parvovirus infection." Voprosy ginekologii, akušerstva i perinatologii 20, no. 4 (2021): 165–69. http://dx.doi.org/10.20953/1726-1678-2021-4-165-169.

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The development of management tactics for pregnant women with congenital infections is the most important medical and social task, since it determines the prognosis and outcome of the disease for the mother and her children. The lack of standardized approaches to the diagnosis and treatment of congenital infectious diseases, as well as the insufficient level of interaction between obstetric and gynecological and infectious diseases services necessitate a comprehensive multidisciplinary approach to the early diagnosis and treatment of congenital infectious diseases in the antenatal period. The article presents our own cases of management of pregnant women with congenital cytomegalovirus and parvovirus B19 infections. Key words: pregnancy, diagnosis, infections, treatment, parvovirus B19, cytomegalovirus
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Dissertations / Theses on the topic "Cytomegalovirus infections Diagnosis"

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Martres, Pascale. "Nouvelles perspectives de diagnostic des infections à cytomégalovirus." Paris 5, 1989. http://www.theses.fr/1989PA05P157.

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HETUIN, ALAIN. "Les infections a cytomegalovirus : aspect clinique et diagnostic a propos de cinq cas et d'une revue de la litterature." Lille 2, 1988. http://www.theses.fr/1988LIL2M088.

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O'Neill, H. J. "Antibody responses during human cytomegalovirus infection in transplant patients and their importance in diagnosis." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373558.

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Hivert, Sylvie. "Comparaison de la virémie CMV, de l'antigénémie pp65 et du bDNA CMV 1. 0 pour évaluer la charge virale CMV chez 24 patients VIH+ dont 7 patients traités par Foscarnet." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P088.

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Sano, Kaoru. "Cytomegalovirus infection in living related liver transplantation : rapid diagnosis by human monoclonal antibody staining of blood leucocytes." Kyoto University, 1997. http://hdl.handle.net/2433/202245.

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DUBAN, BEDU BENEDICTE. "Interet de la polymerase chain reaction, pcr, dans le diagnostic et le suivi des infections a cytomegalovirus humain en transplantation." Lille 2, 1993. http://www.theses.fr/1993LIL2M046.

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Drouet, Emmanuel. "Amplification génique de séquences d'ADN du cytomegalovirus : applications à l'exploration de la virémie cytomégalique et au diagnostic des infections disséminées." Lyon 1, 1991. http://www.theses.fr/1991LYO1T168.

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Chu, Yin Bui. "Evaluation of rapid method for detection of cytomegalovirus in clincal specimens using polymerase chain reaction DNA amplification." FIU Digital Commons, 1993. http://digitalcommons.fiu.edu/etd/2355.

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Human cytomegalovirus (HCMV) infection is the major cause of illness and death in immunocompromised patients. HCMV is the most common cause of congenital viral infection in humans. A polymerase chain reaction (PCR) method was developed for the rapid detection of CMV in urine. Several parameters of the PCR procedure were optimized to reduce time and improve sensitivity. By eliminating the extraction of DNA from clinical specimens, reducing the number of amplification cycles, utilization of the "hot start" PCR procedure and direct detection of PCR product by ethidium bromide fluorescence staining, a procedure was developed which could be performed in less than 3 hours. Comparison studies using cell culture and direct detection of CMV by PCR on urine specimens were performed. Sensitivity was further examined to determine if inhibitors of the PCR reaction were present in urine.
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Vives, Oñós Isabel. "Sensibilidad y especificidad de la técnica de detección de DNA de citomegalovirus en la sangre seca de la prueba de detección precoz neonatal (prueba del talón) mediante PCR en los pacientes afectos de citomegalovirus congénito." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457358.

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La infección congénita por citomegalovirus (CMVc) está considerada la infección congénita más frecuente de los países desarrollados, estimándose su prevalencia en un 0,7% (entre 0,3 y 1,3%). Actualmente, ningún país del mundo realiza cribado universal de CMVc. Para su diagnóstico se debe confirmar la presencia del virus en cualquier fluido corporal (el más frecuentemente usado es la orina) en las dos o tres primeras semanas de vida, pues pasado ese periodo la adquisición puede ser postnatal. Para diferenciar retrospectivamente entre la adquisición pre y postnatal se determina la presencia de DNA del virus mediante PCR en la sangre seca de la prueba de cribado metabólico neonatal. Existen múltiples estudios publicados sobre la sensibilidad de estas técnicas, sólo uno en nuestro país, con sensibilidades entre el 28 y el 100%. El estudio piloto realizado por nuestro grupo en 2014 sobre 14 pacientes mostró una sensibilidad menor (50%) a la descrita en la mayoría de estudios. En este trabajo multicéntrico se ha estudiado la sensibilidad y especificidad de una técnica comercial de rt-PCR (rt-PCR (RealStar CMV®, Altona, Hamburg, Germany)) entre los pacientes del Registro Estatal De Infección Congénita por CMV (REDICCMV), así como los factores relacionados con el resultado. En este trabajo se incluyeron 184 individuos (103 pacientes y 81 controles). Cincuenta y ocho pacientes y dos controles presentaron resultado positivo en la PCR a CMV en sangre seca, lo que equivale a una sensibilidad de la prueba del 56% (95%CI 47-65%), especificidad del 98% (91-99%), razón de probabilidad positiva del 22,81 (5,74-90,58) y razón de probabilidad negativa del 0,45 (0,36-0,60). Al analizar las variables clínicas en relación al resultado de la PCR se observa que únicamente la carga viral al nacimiento tiene relación con la misma: cargas virales más bajas al nacimiento tienen con más frecuencia rt-PCRs negativas en la sangre seca. Sin embargo, al estudiar la correlación entre la carga viral en sangre al nacimiento y en sangre seca (técnica semicuantitativa), no se ha observado ninguna correlación (se ha podido estudiar en 51 pacientes). Como conclusión podemos decir que, con la técnica diagnóstica y metodología utilizadas, ante un resultado negativo de la rt-PCR en la muestra de sangre seca de la prueba de cribado metabólico no podemos descartar infección congénita por CMV, sobre todo en los niños con cargas virales más bajas al nacimiento. Por el contrario, un resultado positivo tiene una elevada especificidad para el diagnóstico de confirmación de CMVc. Es necesario disponer de una técnica definida en cuanto a muestra, extracción, procesamiento e interpretación que permita el diagnóstico retrospectivo de la infección por CMVc cuando ello sea necesario.
Congenital cytomegalovirus (cCMV) is known to be the most common cause of congenital viral infection of the developed countries, its prevalence among 0,7% (between 0,3 and 1,3%). Currently, there is no country worldwide with a universal screening program. The diagnosis of a congenital infection requires the confirmation of the virus in any body fluid (urine is the most commonly used) within the first two or three weeks of life. Afterwards, the detection of CMV can be due to postnatal infection. If we need to make a retrospective diagnosis of congenital or postnatal infection when we suspect the infection after the first two or three weeks of life, the DNA presence of the virus is checked by a PCR technique in dried blood spots (DBS) from the metabolic screening program. There have been many published studies about this topic, only one in Spain, with sensitivities ranging from 28% until 100%. The pilot study made by our group with 14 patients showed a lower sensitivity (50%), compared with those reported in most of the previously published studies. In this multicentric study the sensitivity and specificitiy of a commercial rt-PCR (rt-PCR (RealStar CMV®, Altona, Hamburg, Germany)) has been assessed in the Spanish Registry of Congenital CMV Infection (Registro Estatal De Infección Congénita por CMV (REDICCMV)), as well as the relation between the result and clinical variables. REDICCMV is an online registry including all those cCMV patients from hospitals around the country included in the project. One hundred and eighty-four subjects were included (103 patients and 81 controls). Fifty-eight samples from the patient group in contrast to two among the control samples tested positive by CMV DNA rt-PCR, leading to a sensitivity of 56% (95%CI 47-65%), specificity 98% (91-99%), positive likelihood ratio 22.81 (5.74-90.58) and negative likelihood ratio 0.45 (0.36-0.60). The only variable significantly associated with negative CMV DNA results on DBS testing was the plasma viral load at birth (bPVL): those patients with lower bPVL tested negative more frequently than those with higher bPVL. However, no correlation between bPVL and viral load in DBS (semi quantitative technique) was found in those patients that could be checked for both viral loads (51). In conclusion, with our technique and used methodology, a negative rt-PCR DBS result does not rule out congenital CMV infection, especially in patients with low viremia at birth. In contrast, a positive result has a high specificity for the retrospective diagnosis of cCMV infection. There is a need of an available technique regarding sampling, extraction, processing and result interpretation for the retrospective diagnosis of cCMV when necessary.
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Suárez-Lledó, Grande María. "Infección por Citomegalovirus en el Trasplante Alogénico de Progenitores Hematopoyéticos en la era del tratamiento anticipado: consideraciones actuales sobre la definición de grupos de riesgo y el diagnóstico." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/669231.

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El Citomegalovirus (CMV) es un virus herpes con capacidad de permanecer latente tras la primoinfección y reactivarse durante estados de inmunosupresión. La respuesta inmune celular mediada por los linfocitos T CD8 citotóxicos es la encargada, de manera predominante, del control de la infección por este virus. Los pacientes que reciben un trasplante alogénico de progenitores hematopoyéticos (TPH) presentan un estado de inmunosupresión severa y prolongada. La reconstitución del sistema inmune ocurre de manera escalonada y la de los linfocitos T tiene lugar a partir del tercer mes post-TPH. Complicaciones como la enfermedad injerto contra receptor (EICR) y su tratamiento contribuyen a agravar la inmunosupresión. Por ello, las complicaciones infecciosas son frecuentes, en especial la infección por CMV que afecta al 60% de los pacientes con una mortalidad asociada del 2% (directamente relacionada con la afección de algún órgano) y una mortalidad indirecta, derivada del tratamiento y de la propia infección, cercana al 10%. La presencia de una serología positiva (IgG) en el receptor del TPH es el principal factor de riesgo para presentar infección por CMV, especialmente cuando el donante es seronegativo (alto riesgo). Otros factores de riesgo son la presencia de linfopenia, EICR y su tratamiento, así como fármacos utilizados en la profilaxis de EICR que provoquen linfopenia. En el primer trabajo se demuestra que el tratamiento con corticoides a altas dosis (debido a la presencia de EICR) aumenta la incidencia de infección e infección recurrente por CMV, lo que impacta sobre todo en los pacientes de riesgo intermedio serológico (donante y receptor IgG positivos) y la equipara a la incidencia de los de alto riesgo serológico (donante negativo/receptor positivo), situándola en torno al 80%. En los pacientes de alto riesgo, el tratamiento con corticoides alarga la duración del tratamiento. Además, se evidencia que el tratamiento con corticoides enlentece la reconstitución inmune de manera global y tiene un efecto negativo sobre la inmunidad CMV específica, disminuyendo su eficacia. La administración de ciclofosfamida post-TPH, estrategia eficaz en disminuir la incidencia de EICR, debido al efecto que ejerce sobre la reconstitución inmune post-TPH, provoca un cambio en la epidemiología de la infección, como se describe en el tercer trabajo. La linfopenia profunda que ocurre en el primer mes explicaría la mediana de reactivación más precoz. El retraso en la reconstitución de los linfocitos T CD4, que se iniciaría a los 6 meses post-TPH, explica la mayor incidencia de enfermedad orgánica y, sobre todo, de infección refractaria al tratamiento antiviral. El segundo trabajo se centra en la utilidad de la PCR-RT (cuantificación de DNA viral) como técnica diagnóstica para la manifestación más frecuente de enfermedad por CMV, la gastrointestinal (asociada a mortalidad). Los síntomas derivados del daño causado por el CMV en tejido gastrointestinal son indistinguibles de los provocados por la EICR intestinal. Para llegar al diagnóstico se debe realizar biopsia endoscópica con estudio anatomopatológico y tinción inmunohistoquímica (gold standard). Se demuestra que la PCR-RT en tejido intestinal presenta la misma sensibilidad, especificidad y valores predictivos positivos y negativos que la inmunohistoquímica, lo que la convierte en una técnica fiable. Además, la PCR-RT, gracias a la cuantificación del DNA viral, permite realizar un diagnóstico precoz en base a un punto de corte definido, e iniciar tratamiento antiviral precozmente, así como evaluar la respuesta al mismo, según la evolución de la carga viral. Identificar los factores de riesgo que presenta cada paciente para desarrollar infección por CMV así como el uso de nuevas herramientas disponibles, permite diseñar estrategias individualizadas de tratamiento que sean eficaces en el control de la infección y minimizar la toxicidad asociada para mejorar la supervivencia global de los pacientes.
Cytomegalovirus (CMV) is a herpes virus with the ability to reactivate from a latent phase during immunosuppression. The cellular immune response mediated by cytotoxic CD8 T-lymphocytes is predominantly responsible for the control of CMV infection. Patients who receive an allogeneic stem cell transplant (SCT) experience severe and prolonged immunosuppression. Immune reconstitution after transplant is a stepwise process and T cell recovery begins after the third month after SCT. Complications such as graft-versus-host disease (GVHD) and its treatment contribute to increased immunosuppression. Therefore, infectious complications are frequent, especially CMV infection that affects 60% of patients A positive serology (IgG) in the recipient is the main risk factor for CMV infection, especially when the donor is seronegative (high risk). Other risk factors are the presence of lymphopenia, GVHD and its treatment, and T cell depletion. Our studies show that treatment with high-dose steroids increases the incidence of CMV infection and recurrent infection, especially for intermediate-risk serological patients (IgG-positive donor and recipient). In high-risk patients, steroid treatment prolonged the duration of antiviral treatment. In addition, steroid treatment delays global immune reconstitution and impairs CMV-specific immunity. The administration of post-SCT cyclophosphamide, used for GVHD prophylaxis, changes the CMV infection’s epidemiology. Deep lymphopenia occurring in the first month would explain the earlier median time to CMV infection and the delay in the CD4 T lymphocyte’s recovery (after 6 months post-SCT), explains the higher incidence of CMV disease and refractory CMV infection. We focused on the usefulness of RT-PCR as a diagnostic technique for the CMV gastrointestinal disease. The symptoms derived from CMV gastrointestinal disease are indistinguishable from those caused by GVHD. An endoscopic biopsy with histological study and inmunohistochemistry staining (gold standard) is needed for diagnosis. It has been shown that RT-PCR has the same sensitivity, specificity and predictive values than immunohistochemistry, so PCR is useful and reliable for CMV gastrointestinal disease. Furthermore, PCR-RT (quantification of viral DNA), allows an early diagnosis based on a defined cut-off so would initiate antiviral treatment more promptly. PCR-RT could also be useful for monitoring the response and define the duration of the treatment.
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Books on the topic "Cytomegalovirus infections Diagnosis"

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service), SpringerLink (Online, ed. Congenital Cytomegalovirus Infection: Epidemiology, Diagnosis, Therapy. Vienna: Springer-Verlag Vienna, 2011.

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Susanna, Prösch, Cinatl Jindrich, and Scholz Martin 1960-, eds. New aspects of CMV-related immunopathology. Basel: Karger, 2003.

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Susan, Michelson, and Plotkin Stanley A. 1932-, eds. Multidisciplinary approach to understanding cytomegalovirus disease: Proceedings of the Fourth International Cytomegalovirus Workshop : multidisciplinary approaches to understanding CMV disease, Paris, France, 19-21 April, 1993. Amsterdam: Excerpta Medica, 1993.

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1960-, Scholz Martin, ed. CMV-related immunopathology. Basel [Switzerland]: Karger, 1998.

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AIDS sourcebook: Basic consumer health information about the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), including facts about its origins, stages, types, transmission, risk factors, and prevention, and featuring details about diagnostic testing, antiretroviral treatments, and co-occurring infections, such as cytomegalovirus, mycobacterium avium complex, pneumocystis carinii pneumonia, and toxoplasmosis; along with tips for living with hiv/aids, updated statistics, reports on current research initiatives, a glossary of related terms, and a list of resources for additional help and information. 5th ed. Detroit, MI: Omnigraphics, 2011.

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AIDS sourcebook: Basic consumer health information about the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (aids), including facts about its origins, stages, types, transmission, risk factors, and prevention, and featuring details about diagnostic testing, antiretroviral treatments, and co-occurring infections, such as cytomegalovirus, mycobacterium avium complex, pneumocystis carinii pneumonia, and toxoplasmosis; along with tips for living with hiv/aids, updated statistics, reports on current research initiatives, a glossary of related terms, and a list of resources for additional help and information. Detroit, MI: Omnigraphics, Inc., 2016.

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Halwachs-Baumann, Gabriele. Congenital Cytomegalovirus Infection: Epidemiology, Diagnosis, Therapy. Springer, 2019.

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Schleiss, Mark R. Cytomegalovirus. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190604813.003.0001.

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Congenital infection with human cytomegalovirus (CMV) is the most common infectious cause of developmental disability in newborns. Congenital CMV is also a leading cause of hearing loss in infants. The overall birth prevalence of congenital CMV is 0.5–1%, varying among different populations. CMV infection may be symptomatic at birth or, more commonly, asymptomatic. Both groups are at risk for sequelae. Antiviral therapy with ganciclovir (or valganciclovir) in infants with symptomatic congenital CMV infection can result in improved neurodevelopmental and hearing outcomes. CMV infections in very low birthweight premature infants, typically acquired via breast milk, can also produce substantial short-term and possibility long-term morbidity. This chapter reviews current concepts regarding the biology of CMV as well as the epidemiology, clinical presentation, diagnosis, management, and outcome of congenital and perinatal CMV infections. High-priority areas for future research, including in the arena of newborn screening for congenital CMV, are discussed.
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Bale, James F. Congenital and Perinatal Viral Infections. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0160.

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Despite remarkable advancements in the treatment and prevention of infectious diseases, congenital (also known as intrauterine) and perinatal (also known as neonatal) infections remain major causes of permanent neurodevelopmental disabilities worldwide. Fortunately, relatively few viral pathogens can infect the developing fetus or the newborn postnatally and induce neurological disease. These pathogens include cytomegalovirus, rubella virus, herpes simplex virus types 1 and 2, varicella zoster virus, lymphocytic choriomeningitis virus, the nonpolio enteroviruses, parechovirus, and human immunodeficiency virus. This chapter describes the clinical manifestations, diagnosis, treatment, and outcome of these congenital and perinatal viral infections.
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Kannan, Meena, Harrison Taylor, and William Tyor. HIV Infection. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0148.

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This chapter focuses on four common opportunistic infections of the nervous system associated with HIV infection, namely cryptococcal infection, cytomegalovirus infection, progressive multifocal leukoencephalitis, and toxoplasmosis. Essential features of neurobiology, clinical presentation, differential diagnosis, diagnostic workup, clinical management, and outcome are discussed for each condition. Although combined antiretroviral therapy for HIV has generally reduced the incidence of these complications of HIV infection, they remain important considerations, especially in areas in which antiretrovirals are unavailable or have limited availability.
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Book chapters on the topic "Cytomegalovirus infections Diagnosis"

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Ho, Monto. "Virological Diagnosis and Infections in Cells and Tissues." In Cytomegalovirus, 75–99. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-9942-2_5.

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Kotton, Camille Nelson. "Cytomegalovirus in Solid Organ Transplant Recipients: Prevention, Diagnosis, and Treatment." In Emerging Transplant Infections, 1–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-01751-4_24-1.

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Kotton, Camille Nelson. "Cytomegalovirus in Solid Organ Transplant Recipients: Prevention, Diagnosis, and Treatment." In Emerging Transplant Infections, 547–71. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-25869-6_24.

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Camargo, Jose F. "Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients: Prevention, Diagnosis, and Treatment." In Emerging Transplant Infections, 1–44. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-01751-4_25-1.

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Camargo, Jose F. "Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients: Prevention, Diagnosis, and Treatment." In Emerging Transplant Infections, 573–616. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-25869-6_25.

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Emanuel, David, Joanne Peppard, Jihed Chehimi, Ulrich Hammerling, and Richard O’Reilly. "The Diagnosis, Prevention and Treatment of Human Cytomegalovirus Infections Using Human and Murine Monoclonal Antibodies." In Clinical Applications of Monoclonal Antibodies, 139–48. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1573-5_12.

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Halwachs-Baumann, Gabriele. "Prospects and Obstacles of Diagnosis." In Congenital Cytomegalovirus Infection, 75–89. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-98770-5_4.

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Halwachs-Baumann, Gabriele. "Prospects and obstacles of diagnosis." In Congenital Cytomegalovirus Infection, 75–89. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0208-4_4.

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Chen, Harold. "Congenital Cytomegalovirus Infection." In Atlas of Genetic Diagnosis and Counseling, 1–12. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6430-3_50-2.

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Chen, Harold. "Congenital Cytomegalovirus Infection." In Atlas of Genetic Diagnosis and Counseling, 553–63. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-2401-1_50.

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Conference papers on the topic "Cytomegalovirus infections Diagnosis"

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Shakhgildyan, V. I., M. S. Yadrikhinskaya, А. А. Orlovsky, О. Y. Shipulina, E. A. Domonova, and Е. В. Yarovaya. "CYTOMEGALOVIRUS DNA CONCENTRATION IN BIOLOGICAL SAMPLES AS A KEY TO THE DIAGNOSIS OF CMV PNEUMONIA IN HIV-INFECTED PATIENTS." In Молекулярная диагностика и биобезопасность – 2020. ФБУН Центральный НИИ эпидемиологии Роспотребнадзора, 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-86.

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According to examination and follow-up results of 5485 HIV-positive hospitalized patients (3333 of which were diagnosed with AIDS) we have identified the frequency of clinically evident CMV-infection as well as the frequency and character of CMV related lung disease. Statistically significant correlation between viral load, degree of immunosuppression, CMV replication rate and CMV pneumonia development risk has been determined. Qualitative PCR assay for CMV DNA in plasma and respiratory samples was found to have high sensitivity and low specificity for diagnosing CMV-pneumonia. We identified quantitative PCR CMV DNA values in blood cells, plasma, bronchoalveolar lavage, bronchi samples and sputum that confirm the diagnosis of CMV pneumonia with 95% and 99% probability, and exclude CMV related lung damage in HIV patients with 90% and 99% probability.
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Lefrere, J. J., D. Vittecoq, D. Gozin, and J. Modai. "CIRCULATING ANTICOAGULANT IN AIDS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644859.

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The frequency of a circulating anticoagulant has been reported to be high in AIDS, in particular in case of Pneumocystic carinii pneumonia (Pep). Twenty-five non-hemophiliac patients (23 homosexual males,1 drug addict, 1 tranfused) with AIDS were followed over a six month period. Mean age was 32 (21-42). All patients had a markedly decreased T4/T8 ratio (mean 0.12), a low absolute T4 level (mean : 155/mm3), an elevated total serum immunoglobulins level.Activated partial thromboplastin time (APTT), prothrombintime and thrombin time were measured once a week during hospitalisation. A prolonged APTT (more than 10 seconds as compared to controls) with normal prothrombin time and thrombin time was found only once in 11patients and in two or more occasions in two others.No specific factor level of intrinsic pathway wasfound low enough to explain a prolonged APTT.Evidenceofcirculating anticoagulant (failure to correct aprolonged APTT by equal mixure of normal plasma and patient plasma) was found in all these 13 patients.Nothrombotic or haemorraghic manifestations occured.AIDS manifestations were 2 Pep.1 cytomegalovirus retinitis. 2 Kaposi's sarcomas, 1 Hodgkin's disease, 2 mycobacterium avium intracellulare pulmonary infection, 4 central nervous system toxoplasmosis, 1 Cryptococcus meningitis. Amongst the 12 patients with normal APTT,3_Pcp, 2 cytomegalovirus retinitis. 2 Kaposi's sarcomas, 2 central nervous system toxoplasmosis, 1 unexplained fever, and 2 oesophagus candidiasis were diagnosed. A transiently prolonged APTT associated to a circulating inhibitor seems to be common in AIDS. Weobserved this anomaly in 52 % (13/25). In our five cases of Pcp, 3 had normal APTT. During other opportunistic infections, the circulating inhibitor was found.The similar complications seen in two groups suggest that a circulating anticoagulant is not specifically associated to any opportunistic infection and any malignancybut appearr independently from these circumstances.
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