Academic literature on the topic 'Cytochrome P-450'
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Journal articles on the topic "Cytochrome P-450"
Izotov, MV, VM Shcherbakov, VM Devichensky, SM Spiridonova, LV Lugovaja, and SA Benediktova. "The ratio of two isozyme groups in microsomal cytochrome P‐450 under exogenous influence of carbon tetrachloride and cyclophosphamide." Biotechnology and Applied Biochemistry 10, no. 6 (December 1988): 545–50. http://dx.doi.org/10.1111/j.1470-8744.1988.tb00042.x.
Full textWHITE, R. E. "Cytochrome P-450: Cytochrome P-450." Science 234, no. 4778 (November 14, 1986): 884. http://dx.doi.org/10.1126/science.234.4778.884.
Full textKapitulnik, J., J. P. Hardwick, J. D. Ostrow, C. C. Webster, S. S. Park, and H. V. Gelboin. "Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats." Biochemical Journal 242, no. 1 (February 15, 1987): 297–300. http://dx.doi.org/10.1042/bj2420297.
Full textStrobel, Henry W., Steven G. Nadler, and David R. Nelson. "Cytochrome P-450: Cytochrome P-450 Reductase Interactions." Drug Metabolism Reviews 20, no. 2-4 (January 1989): 519–33. http://dx.doi.org/10.3109/03602538909103558.
Full textPessayre, D. "Cytochrome P 450." La Revue de Médecine Interne 10, no. 1 (January 1989): 23–24. http://dx.doi.org/10.1016/s0248-8663(89)80108-0.
Full textPompon, D., and P. Urban. "Cytochrome P-450." Biochimie 76, no. 1 (January 1994): 89. http://dx.doi.org/10.1016/0300-9084(94)90068-x.
Full textJacobs, J. M., P. R. Sinclair, W. J. Bement, R. W. Lambrecht, J. F. Sinclair, and J. A. Goldstein. "Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d." Biochemical Journal 258, no. 1 (February 15, 1989): 247–53. http://dx.doi.org/10.1042/bj2580247.
Full textReed, C. J., E. A. Lock, and F. De Matteis. "NADPH: cytochrome P-450 reductase in olfactory epithelium Relevance to cytochrome P-450-dependent reactions." Biochemical Journal 240, no. 2 (December 1, 1986): 585–92. http://dx.doi.org/10.1042/bj2400585.
Full textSinclair, J. F., S. Wood, L. Lambrecht, N. Gorman, L. Mende-Mueller, L. Smith, J. Hunt, and P. Sinclair. "Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by h.p.l.c. and their enzymic characterization." Biochemical Journal 269, no. 1 (July 1, 1990): 85–91. http://dx.doi.org/10.1042/bj2690085.
Full textSong, B. J., H. V. Gelboin, S. S. Park, and F. K. Friedman. "Epitope-relatedness and phenotyping of hepatic cytochromes P-450 with monoclonal antibodies." Biochemical Journal 231, no. 3 (November 1, 1985): 671–76. http://dx.doi.org/10.1042/bj2310671.
Full textDissertations / Theses on the topic "Cytochrome P-450"
Clarke, Stephen Edward. "Characterisation of housefly cytochrome P-450." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/847312/.
Full textJones, Barry Christopher. "Cytochrome P-450 mediated N-dealkylation." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/844436/.
Full textBoitrel, Bernard. "Modeles d'hemoproteines : hemoglobine et cytochrome p-450." Paris 6, 1989. http://www.theses.fr/1989PA066059.
Full textKrause, Maren. "Genetische Variabilität des Cytochrom P 450- Systems im Zusammenhang mit einem erhöhten Risiko für Rheumatoide Arthritis." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-143774.
Full textChassagne, Philippe. "Expression des cytochromes P-450 pancréatiques." Montpellier 1, 1994. http://www.theses.fr/1994MON11135.
Full textZhao, Jin 1975. "Investigations of the biocatalytic activity of human P450 2D6." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111940.
Full textWe have tested inexpensive chemicals to replace the natural cofactors of CYP2D6, NADPH and cytochrome P450 reductase (CPR). The results showed that cumene hydroperoxide and tert-butyl hydroperoxide can successfully substitute CPR and NAD(P)H with retained regio- and stereo-selectivity. Moreover, with these surrogates, product formation and initial rates are increased by as much as two fold compared to the use of the natural cofactors.
It is widely accepted that even small proportions of organic solvents in the buffer can deactivate most enzymes including P450s. Our studies on the biocatalysis of CYP2D6 in organic solvent/buffer emulsions showed that under the optimized conditions, as much as 76% of the enzyme activity was retained. Product formation in biphasic solvent systems is comparable whether the natural redox partner and cofactor are used, or a surrogate. In addition, a correlation was observed between the log P and the suitability of a solvent for enzymatic activity, with higher log P resulting in higher enzymatic activity. These results were obtained with dextromethorphan (DXM), a water soluble substrate. A very hydrophobic substrate, 7-benzyloxy-4-N,N-diethylaminomethyl-coumarin (BDAC), was also tested successfully to demonstrate the utility of this method.
Lyophilization is usually required to remove water before using enzymes in nearly anhydrous solvents. This physical process is harmful to P450 enzyme activity. We therefore tested numerous sugars as lyoprotectant during lyophilization. Addition of trehalose or sucrose before lyophilization allowed the retention of 80% of the CYP2D6 activity, compared to 40% remaining activity in its absence. CYP2D6 co-lyophilized with trehalose was next tested in selected hydrophobic organic solvents in the absence of water. The enzymatic activity was found to strongly depend on the hydrophobicity of the solvent. Interestingly, the enzyme showed higher catalytic ability in n-decane or n-dodecane than in the standard buffer. This was unexpected considering that the activity of most enzymes was reported to decrease to 10% or less in nearly anhydrous organic solvents.
The last objective of this thesis was to improve the stability and/or activity of CYP2D6. Use of DNA self-assemblies to encapsulate P450 enzymes was envisaged to potentially increase their stability. Indeed, DNA assemblies have many advantages compared to traditional solid supports reported for enzymes. Our preliminary results showed that CYP2D6 templated the formation of cyclic DNA dimeric and tetrameric over polymeric self-assemblies. Characterization of the CYP2D6 activity in the presence of the DNA self-assemblies revealed no loss of activity or stability.
Rodrigues, N. R. "The human cytochrome P-450 21-hydroxylase genes." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:77be8950-4675-4a55-ab4f-27b788082007.
Full textSlatcher, Guy. "The mechanistic enzymology of cytochrome P-450 aromatase." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307085.
Full textChow, Cathy Sze-Yu. "Selective hydroxylations catalysed by cytochrome P-450 monooxygenases." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/13386.
Full textHawkes, David B. "Cytochrome P450cin /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17457.pdf.
Full textBooks on the topic "Cytochrome P-450"
1930-, Omura Tsuneo, Ishimura Yuzuru 1935-, and Fujii-Kuriyama Yoshiaki, eds. Cytochrome P-450. 2nd ed. Tokyo: Kodansha, 1993.
Find full textde Montellano, Paul R. Ortiz, ed. Cytochrome P-450. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2.
Full textEmel, Arinç, Schenkman John B, and Greim Helmut, eds. Cytochrome P450. Berlin: Springer-Verlag, 1993.
Find full textPaul R. Ortiz de Montellano, Ian R. Phillips, and Elizabeth A. Shephard. Cytochrome P450 protocols. 3rd ed. New York: Humana, 2013.
Find full textOrtiz de Montellano, Paul R., ed. Cytochrome P-450: Structure, mechanism, and biochemistry. New York: Plenum Press, 1986.
Find full text1951-, Phillips Ian R., and Shephard Elizabeth A. 1950-, eds. Cytochrome P450 protocols. 2nd ed. Totowa, N.J: Humana Press, 2005.
Find full textR, Waterman Michael, and Johnson Eric F, eds. Cytochrome P450. San Diego: Academic Press, 1991.
Find full textPeter, Guengerich F., ed. Mammalian cytochromes P-450. Boca Raton, FL: CRC Press, 1987.
Find full textOrtiz de Montellano, Paul R., ed. Cytochrome P-450: Structure, mechanismand biochemistry. New York: Plenum, 1986.
Find full text1946-, Bachmanova G. I., ed. Cytochrome P-450 and active oxygen. London: Taylor & Francis, 1990.
Find full textBook chapters on the topic "Cytochrome P-450"
Peterson, Julian A., and Russell A. Prough. "Cytochrome P-450 Reductase and Cytochrome b5 in Cytochrome P-450 Catalysis." In Cytochrome P-450, 89–117. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_4.
Full textSligar, Stephen G., and Ralph I. Murray. "Cytochrome P-450cam and Other Bacterial P-450 Enzymes." In Cytochrome P-450, 429–503. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_12.
Full textMcMurry, Thomas J., and John T. Groves. "Metalloporphyrin Models for Cytochrome P-450." In Cytochrome P-450, 1–28. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_1.
Full textWaterman, Michael R., Maliyakal E. John, and Evan R. Simpson. "Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways." In Cytochrome P-450, 345–86. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_10.
Full textJefcoate, Colin R. "Cytochrome P-450 Enzymes in Sterol Biosynthesis and Metabolism." In Cytochrome P-450, 387–428. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_11.
Full textPoulos, Thomas L. "The Crystal Structure of Cytochrome P-450cam." In Cytochrome P-450, 505–23. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_13.
Full textMarnett, Lawrence J., Paul Weller, and John R. Battista. "Comparison of the Peroxidase Activity of Hemeproteins and Cytochrome P-450." In Cytochrome P-450, 29–76. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_2.
Full textMiwa, Gerald T., and Anthony Y. H. Lu. "The Topology of the Mammalian Cytochrome P-450 Active Site." In Cytochrome P-450, 77–88. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_3.
Full textIngelman-Sundberg, Magnus. "Cytochrome P-450 Organization and Membrane Interactions." In Cytochrome P-450, 119–60. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_5.
Full textBlack, Shaun D., and Minor J. Coon. "Comparative Structures of P-450 Cytochromes." In Cytochrome P-450, 161–216. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-9939-2_6.
Full textConference papers on the topic "Cytochrome P-450"
D’yachkov, P. N. "Quantum chemical simulation of the cytochrome P 450 catalyzed oxidation and toxicity of benzene derivatives." In The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47657.
Full textDervisis, Nikolaos G., Maciej Parys, Annet Wenker, Patrick Venta, Barbara E. Kitchell, and Vilma Yuzbasiyan-Gurkan. "Abstract 2661: Evaluation of genetic variability of cytochrome P-450 members in the canine preclinical model." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2661.
Full textFenile, R., A. Nazário, and G. Facina. "P5-05-07: The Msp1 Polymorphism of Cytochrome P-450 CYP1A1 in Asymptomatic Women with Breast Cysts." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p5-05-07.
Full textMarcus, A. J., L. B. Safier, H. L. Ullman, N. Islam, M. J. Broekman, and C. V. Schacky. "NEW EICOSANOIDS FORMED DURING PLATELET-NEUTROPHIL INTERACTIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644626.
Full textReports on the topic "Cytochrome P-450"
Carpenter, Hillary M., and Lawrence R. Curtis. Pharmacokinetics of Lipophilic Agents Following Preexposure: Non-Cytochrome P-450 Mediated Mechanisms. Fort Belvoir, VA: Defense Technical Information Center, May 1990. http://dx.doi.org/10.21236/ada225356.
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