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Relevant bibliographies by topics / Cysteine, N-acetyl Cysteine

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Academic literature on the topic 'Cysteine, N-acetyl Cysteine'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Cysteine, N-acetyl Cysteine"

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De Vries, Nico, and Silvio De Flora. "N-acetyl-l-cysteine." Journal of Cellular Biochemistry 53, S17F (1993): 270–77. http://dx.doi.org/10.1002/jcb.240531040.

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Martínez-Banaclocha, Marcos. "N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome." Current Medicinal Chemistry 27, no. 37 (November 6, 2020): 6424–39. http://dx.doi.org/10.2174/0929867326666191015091346.

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Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, no one seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected sensitive cysteine-containing proteins (SCCPs) that together with reactive species and the cysteine/glutathione cycles can regulate the bioenergetic metabolism, the redox homeostasis and the cellular growth, differentiation and survival, acting through different pathways that are regulated by the same thiol radical in cysteine residues. Objective: Since this sensitive cysteine network has been implicated in the pathogenesis of Parkinson and Alzheimer´s diseases, I have reviewed if the proteins that play a role in schizophrenia can be classified too as SCCPs. Results: I have revised the major proteins implicated in the physiopathology of schizophrenia searching for those proteins that are redox-regulated through sensitive cysteine thiols. Results show that the principal proteins playing a role in schizophrenia can be classified as SCCPs, suggesting that the sensitive cysteine proteome (cysteinet) is defective in this type of psychosis. Conclusion: The present review proposes that there is a deregulation of the sensitive cysteine proteome in schizophrenia as the consequence of a functional imbalance among different SCCPs, which play different functions in neurons and glial cells. In this context, the role of NAC to restore and prevent schizophrenic disorders is discussed.

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Park, Taehoon, Ju-Hee Oh, Joo Hyun Lee, Sang Park, Young Jang, and Young-Joo Lee. "Oral Administration of (S)-Allyl-l-Cysteine and Aged Garlic Extract to Rats: Determination of Metabolites and Their Pharmacokinetics." Planta Medica 83, no. 17 (May 30, 2017): 1351–60. http://dx.doi.org/10.1055/s-0043-111895.

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Abstract(S)-Allyl-l-cysteine is the major bioactive compound in garlic. (S)-Allyl-l-cysteine is metabolized to (S)-allyl-l-cysteine sulfoxide, N-acetyl-(S)-allyl-l-cysteine, and N-acetyl-(S)-allyl-l-cysteine sulfoxide after oral administration. An accurate LC-MS/MS method was developed and validated for the simultaneous quantification of (S)-allyl-l-cysteine and its metabolites in rat plasma, and the feasibility of using it in pharmacokinetic studies was tested. The analytes were quantified by multiple reaction monitoring using an atmospheric pressure ionization mass spectrometer. Because significant quantitative interference was observed between (S)-allyl-l-cysteine and N-acetyl-(S)-allyl-l-cysteine as a result of the decomposition of N-acetyl-(S)-allyl-l-cysteine at the detector source, chromatographic separation was required to discriminate (S)-allyl-l-cysteine and its metabolites on a reversed-phase C18 analytical column with a gradient mobile phase consisting of 0.1% formic acid and acetonitrile. The calibration curves of (S)-allyl-l-cysteine, (S)-allyl-l-cysteine sulfoxide, N-acetyl-(S)-allyl-l-cysteine, and N-acetyl-(S)-allyl-l-cysteine sulfoxide were linear over each concentration range, and the lower limits of quantification were 0.1 µg/mL [(S)-allyl-l-cysteine and N-acetyl-(S)-allyl-l-cysteine] and 0.25 µg/mL [(S)-allyl-l-cysteine sulfoxide and N-acetyl-(S)-allyl-l-cysteine sulfoxide]. Acceptable intraday and inter-day precisions and accuracies were obtained at three concentration levels. The method satisfied the regulatory requirements for matrix effects, recovery, and stability. The validated LC-MS/MS method was successfully used to determine the concentration of (S)-allyl-l-cysteine and its metabolites in rat plasma samples after the administration of (S)-allyl-l-cysteine or aged garlic extract.

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Hickman, RJS, BJ Christie, RW Guy, and TJ White. "Synthesis of Aromatic S-Sustituted Derivatives of N-Acetyl-L-cysteine." Australian Journal of Chemistry 38, no. 6 (1985): 899. http://dx.doi.org/10.1071/ch9850899.

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A new method for the preparation of aromatic, S-substituted derivatives of N-acetyl-L- cysteine is described. The method involves nucleophilic substitution of aromatic iodides by N-acetyl-L- cysteine in the presence of copper(I) iodide, and provides the first example of nucleophilic substitution of unactivated aromatic halides by N-acetyl-L- cysteine . The method has been used to prepare N-acetyl-S-(2-thienyl)-L- cysteine and N-acetyl-S-(3-thienyl)-L- cysteine from 2-iodothiophen and 3-iodothiophen respectively. In addition, the method has been successfully applied to iodobenzene and 1-iodonaphthalene. A product yield of about 30% was obtained in each case.

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Uttamsingh, Vinita, D. A. Keller, and M. W. Anders. "Acylase I-Catalyzed Deacetylation ofN-Acetyl-l-cysteine andS-Alkyl-N-acetyl-l-cysteines‡." Chemical Research in Toxicology 11, no. 7 (July 1998): 800–809. http://dx.doi.org/10.1021/tx980018b.

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Makarov, Sergei V., Elizaveta A. Pokrovskaya, Denis S. Salnikov, and Anastasiya V. Amanova. "INFLUENCE OF L-CYSTEINE AND N-ACETYL-L-CYSTEINE ON REDUCING ACTIVITY OF THIOUREA DIOXIDE IN AQUEOUS SOLUTIONS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 10 (September 8, 2020): 4–10. http://dx.doi.org/10.6060/ivkkt.20206310.6257.

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The influence of L-cysteine and N-acetyl-L-cysteine on the stability and reducing activity of thiourea dioxide (NH2)2CSO2 (TDO) in the reaction with azo dye Orange II has been studied. The addition of L-cysteine and N-acetyl-L-cysteine leads to the increase in reducing activity of TDO in weakly acidic, neutral and weakly alkaline solutions, but does not influence its reducing activity in strongly alkaline solutions. In alkaline solutions, the rate of reduction of Orange II is increasing, but the influence of additives of thiol acids is decreasing. The activating effect of N-ace-tyl-L-cysteine is weaker than the effect of L-cysteine, that can be explained by the differences of pKa of these acids. Indeed, the reducing activity of thiols depends on the concentration of thiolate-ions in solutions. Since pKa of cysteine (8.30) is significantly less than pKa of N-acetyl-L-cysteine (9.52), concentration of thiolate-ions in cysteine solutions is higher. Therefore, reducing activity of L-cysteine is higher. The influence of L-cysteine and N-acetyl-L-cysteine on the reaction of TDO with Orange II is different from the influence of aminoacid glycine: in neutral solutions glycine decreases the rate of reaction. The interaction of TDO with L-cysteine in weakly acidic, neutral and weakly alkaline solutions is accompanied by the oxidation of L-cysteine to cysteinesulfenic acid and reduction of TDO to thiourea monoxide (NH2)2CSO. Then cysteinesulfenic acid reacts with L-cysteine with formation of cystine. The reaction studied here is the first example of reduction of TDO by sulfur-containing compounds.

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Kandiş, Hayati, Melih Engin Erkan, Ümran Yildirim, Harun Güneş, Mesut Erbaş, Hayriye AK Yildirim, Suat Gezer, and İsmail Hamdi Kara. "Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication." Human & Experimental Toxicology 30, no. 9 (November 29, 2010): 1350–58. http://dx.doi.org/10.1177/0960327110391384.

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Aim: The aim of the present study was to investigate the therapeutic and preventive effects of N-acetyl cysteine and erdosteine on renal injury associated with paracetamol (acetaminophen) intoxication. Materials and methods: Female albino Wistar rats were divided into six groups: control; paracetamol (1 g/kg, oral); paracetamol (1 g/kg, oral) + erdosteine (150 mg/kg/day, oral); paracetamol (1 g/kg, oral) + N-acetyl cysteine (140 mg/kg bolus, followed by 70 mg/kg, oral); N-acetyl cysteine control (140 mg/kg bolus, followed by 70 mg/kg, oral); and erdosteine control (150 mg/kg/day, oral). Potential renal injury was assessed using biochemical analyses, radionuclide imaging, and histopathological parameters. Results: In the paracetamol group, blood urea nitrogen and creatinine levels were significantly increased compared with controls. Histopathological examination showed tubular vacuolization, tubular necrosis, and remarkable interstitial inflammation. The excretion function was observed to be insufficient on radionuclide imaging. However, in the groups treated with erdosteine or N-acetyl cysteine after paracetamol, biochemical analyses, radionuclide imaging, and histopathological parameters showed significantly less evidence of renal toxicity than that observed in the group receiving paracetamol alone. Less renal toxicity was detected in rats receiving N-acetyl cysteine than in those receiving erdosteine. Conclusion: Renal injury may develop after paracetamol overdose. Erdosteine and N-acetyl cysteine are both effective in the prevention of renal injury when given in the early phase of paracetamol nephrotoxicity. N-acetyl cysteine is more protective than erdosteine.

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Somdas, Mehmet Akif, Inayet Gunturk, Deniz Avci, Cevat Yazici, Esra Balcioglu, Selim Unsal, and Mehmet Gunduz. "N-Acetyl Cysteine Reduces Cisplatin Ototoxicity." Erciyes Tıp Dergisi/Erciyes Medical Journal 38, no. 3 (October 10, 2016): 111–14. http://dx.doi.org/10.5152/etd.2016.0068.

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Mohamed, Zubair Umer, Lakshmi Krishnakumar, and Surendran Sudhindran. "N-acetyl cysteine in liver resection." Journal of Surgical Oncology 114, no. 6 (September 22, 2016): 773. http://dx.doi.org/10.1002/jso.24389.

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Khayyat, Ahdab, Weili Fan, Shakila Tobwala, and Nuran Ercal. "Comparative Evaluation Between N-Acetyl Cysteine and N-Acetyl Cysteine Amide in Acetaminophen-Induced Oxidative Stress." Free Radical Biology and Medicine 53 (November 2012): S108. http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.260.

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Dissertations / Theses on the topic "Cysteine, N-acetyl Cysteine"

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KUO, MING-WEN. "ROLE OF N-ACETYL CYSTEINE IN PREVENTING AGE-RELATED HEARING LOSS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172356377.

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Karalija, Amar. "Diagnostic and therapeutic strategies following spinal cord and brachial plexus injuries." Doctoral thesis, Umeå universitet, Anatomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127519.

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Traumatic injuries to the spinal cord and brachial plexus induce a significant inflammatory response in the nervous tissue with progressive degeneration of neurons and glial cells, and cause considerable physical and mental suffering in affected patients. This thesis investigates the effects of the antioxidants N-acetyl-cysteine (NAC) and acetyl-L- carnitine (ALC) on the survival of motoneurons in the brainstem and spinal cord, the expression of pro-apoptotic and pro-inflammatory cell markers, axonal sprouting and glial cell reactions after spinal hemisection in adult rats. In addition, a novel MRI protocol has been developed to analyse the extent of neuronal degeneration in the spinal cord. Rubrospinal neurons and tibial motoneurons were pre-labelled with the fluorescent tracer Fast Blue one week before cervical C3 or lumbar L5 spinal cord hemisection. The intrathecal treatment with the antioxidants NAC (2.4mg/day) or ALC (0.9 mg/day) was initiated immediately after injury using Alzet2002 osmotic mini pumps. Spinal cord injury increased the expression of apoptotic cell markers BAX and caspase 3, induced significant degeneration of rubrospinal neurons and spinal motoneurons with associated decrease in immunoreactivity for microtubule-associated protein-2 (MAP2) in dendritic branches, synaptophysin in presynaptic boutons and neurofilaments in nerve fibers. Immunostaining for the astroglial marker glial fibrillary acidic protein and microglial markers OX42 and ED1 was markedly increased. Treatment with NAC and ALC attenuated levels of BAX, caspase 3, OX42 and ED1 expression after 2 weeks postoperatively. After 4-8 weeks of continuous intratheca ltreatment, NAC and ALC rescued approximately half of the rubrospinal neurons and spinal motoneurons destined to die, promoted axonal sprouting, restored the density of MAP2 and synaptophysin immunoreactivity and reduced the microglial reaction. However, antioxidant therapy did not affect the reactive astrocytes in the trauma zone. The inflammation modulating properties of ALC were also studied using cultures of human microglial cells. ALC increased the microglial production of interleukin IL-6 and BDNF, thereby possibly mediating the anti-inflammatory and pro-regenerative effects shown in vivo. To study degeneration in the spinal cord following pre-ganglionic and post-ganglionic brachial plexus injuries, adult rat models of ventral root avulsion and peripheral nerve injury were used. A novel MRI protocol was employed and the images were compared to morphological changes found in histological preparations. Ventral root avulsion caused degeneration of dendritic branches and axonal terminals in the spinal cord, followed by significant shrinkage of the ventral horn. Extensive astroglial and microglial reactions were detected in the histological preparations. Peripheral nerve injury reduced the density of dendritic branches but did not cause shrinkage of the ventral horn. Quantitative analysis of MRI images demonstrated changes in the ventral horn following ventral root avulsion only, thus validating the developed MRI technique as a possible tool for the differentiation of pre-ganglionic and post-ganglionic nerve injuries.

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Cheng, Huiwen. "Effects of N-acetyl-L-cysteine and Nitric Oxide-releasing Nonsteroidal Anti-Inflammatory Drugs on Breast Cancer and Melanoma Cell Adhesion." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1384948906.

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Moore, Thomas B. "The Role of N-acetyl-L-Cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients with Inadequately Controlled Chronic Neuropathic Pain." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4315.

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Introduction. While opioid medications are commonly prescribed for management of neuropathic pain (NP), long-term use has been associated with increased risk for overdose, drug interactions and addiction. New strategies are necessary to better manage chronic pain, thereby reducing need for opioid medications and their associated adverse consequences. N-acetyl-L-cysteine (NAC), an over-the-counter supplement, has shown promise in the treatment of psychiatric and addictive disorders. In addition, NAC has shown promise for reducing physiological signs of NP in laboratory rat models, prompting this study. Purpose. The present study was an open-label clinical trial of NAC as an adjuvant to opioid treatment for poorly controlled, chronic NP. It examined whether 1200 mg NAC twice daily for 4 weeks was associated with: lower ratings of patient-reported pain; reductions in PRN opioid medication for breakthrough pain; and improvements in physical and mental health quality of life (QoL). The study also examined whether appraisal of pain impacts response to medication. Method. Participants were N=28 chronic NP patients who consented to study participation. This consisted of 2 baseline assessments, 4 weeks of NAC and 1 post-trial follow-up visit. The majority (N=17) dropped out or were excluded during baseline. Of the remaining participants, N = 11 started the study medication and N=10 completed the study, with daily recordings of pain severity ratings and use of PRN opioid medication. Small sample size limited analyses to qualitative case reviews and effect sizes. Results. Over 90% of participants receiving NAC completed the study. Case review found varied results. While 4 of 10 participants showed decrease in average pain ratings during NAC, estimated effect sizes for the whole sample were small, bordering on negligible (ω² from .003 to .027) as were those for PRN opioids (Partial Eta-Squared=.0003). Effect size for mental health QoL was medium (Cohen's d=.421). Conclusions. With N=10, findings must be interpreted with caution. Nonetheless, the study found some albeit small evidence supporting NAC for improving mental health QoL and pain ratings. Several participants reported improvements in pain and mental health domains while taking NAC. NAC was well tolerated with minimal side effects. Lessons from this study will inform design and implementation of future NAC studies.

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Realini, Giulia. "N-acetyl-L-cysteine ethyl ester (NACET) as a potential therapeutic strategy for the prevention and treatment of Age-related Macular Degeneration." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1203143.

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Age-related macular degeneration (AMD) is a multifactorial progressive chronic ocular disease. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease. Dysfunction of retinal pigment epithelium (RPE) is involved in AMD and oxidative stress in RPE is one of the major causes of the etiopathogenesis of AMD. Therefore, the introduction of antioxidants may represent one of the most effective ways to delay the onset of AMD. Glutathione (GSH) is a key player in the detoxification of xenobiotics, their metabolites and of reactive oxygen species (ROS) and consequently many drugs are currently in use as GSH enhancers. N-acetyl-L-cysteine ethyl ester (NACET) is a lipophilic and cell permeable GSH prodrug that has been proposed to delay AMD progression. Here, we reported an RNA-seq transcriptome analysis of human Retinal Pigment Epithelial cells (ARPE-19) and described for the first time that NACET induces transcriptional activation of nuclear factor erythroid 2-related factor 2 (NRF2) target genes. NRF2 is a transcription factor that allows the maintenance of redox homeostasis by binding to the antioxidant responsive elements (ARE) in the upstream promoter region of many antioxidative genes and thereby inducing their transcription. By means of HPLC analysis, RT-qPCR, Western blot analysis, CRISPR-Cas9 gene editing and luciferase assay, we validated the transcriptome analysis and demonstrated that NACET increases the intracellular level of free cysteine and promotes transcriptional activation of NRF2 target genes through inhibition of NRF2 degradation. Moreover, using transcriptional profiling of retina of young and old mice orally treated with NACET, we showed that NACET rescued 57 genes impaired by aging, many of which have been correlated with retinal dysfunctions. Our study suggests that NACET, as cysteine and GSH precursor and as NRF2 activator, may be a useful tool for the treatment of oxidative stress-related retinal diseases. Although we tested NACET focusing on AMD, we also verified that NACET-induced NRF2 activation is not cell-context dependent, suggesting that NACET may be a promising agent for prevention/treatment of any pathology where oxidative stress is involved.

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Schenatto, Ricardo Olimpio. "Uso da N-acetil-L-cisteína no resfriamento de sêmen equino." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/181359.

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Este estudo teve como objetivo avaliar o efeito da N-acetil-L-cisteína (NAC), adicionada ao diluente composto de leite em pó desnatado, sobre a viabilidade espermática e o estresse oxidativo do sêmen equino resfriado a 5°C. Ejaculados de 8 pôneis da raça Brasileira foram coletados em triplicata resultando em 24 ejaculados. O sêmen foi distribuído em 4 grupos: Equidil® + 0,00 mM (controle), 0,5 mM, 1,0 mM ou 2,5 mM de NAC. As amostras foram armazenadas em tubos de 15mL e mantidas em caixas de transporte de sêmen BotuFLEX® (Botupharma, Botucatu-SP, Brasil). Parâmetros como motilidade total (MT), motilidade progressiva (MP), vigor, pH, resposta ao teste hiposmótico (HOST) e atividade mitocondrial (MTT) foram avaliados nas 24 e 48 h, bem como no sêmen fresco, após a diluição. O vigor, MT e MP foram também avaliados após teste de termorresistência (TTR), na ausência e presença de peróxido. A MT, a MP, o vigor espermático e a MTT foram similares (P > 0.05) entre as concentrações de NAC, nas 24 e 48 h. A resposta ao HOST foi semelhante entre as concentrações de NAC (P > 0,05) nas 24 h de resfriamento, porém nas 48 h ocorreu diminuição da funcionalidade da membrana no grupo NAC 2,5 mM em comparação ao grupo EQUIDIL, sem adição de NAC. A MT, a MP e vigor, das amostras resfriadas por 24 h e submetidas ao TTR, diferiu entre sem e com peróxido (P < 0,05) nos grupos Equidil, 0,5 mM e 1,0 mM, mas foi similar na concentração de 2,5 mM de NAC. Quando o sêmen foi resfriado por 48 h, houve diferença no vigor e MT entre amostras com e sem peróxido (P < 0,05), em todos os grupos testados, mas a MP foi similar entre amostras com e sem peróxido, na concentração 2,5 mM. O pH do diluente Equidil® foi o maior e os grupos Equidil + 0,5 mM e 1,0 mM tiveram valores intermediários, enquanto a concentração de 2,5 mM de NAC gerou valores mais baixos, nos três momentos avaliados (P < 0,05). Não houve variação significativa de pH entre os momentos 0 e 24 h (P= 0,7075) e entre 0 e 48 h (P= 0,4617), em todos os grupos testados. As concentrações de NAC testadas não melhoraram a motilidade, integridade da membrana plasmática, atividade mitocondrial e resposta ao HOST de espermatozoides equinos resfriados a 5°C e armazenados por 48 h. Após TTR, as concentrações de NAC testadas não evitaram a diminuição da motilidade e vigor espermático, na presença de peróxido.
The aim of this study was to evaluate the effect of N-acetyl-L-cysteine (NAC) based on skim milk powder extender on sperm viability and oxidative stress of equine semen cooled to 5°C. Ejaculate of 8 ponies of the Brazilian breed were collected in triplicate, resulting in 24 ejaculates, distributed in 4 groups: Equidil® extender + 0.00mm (control), 0.5mM, 1.0mM and 2.5mM of NAC with the semen samples were The samples were stored in 15mL tubes and kept in BotuFLEX® semen transport boxes (Botupharm, Botucatu/SP/Brazil). Parameters, such as motility, vigor, pH, osmolarity, HOST, and MTT were evaluated at 24 and 48 h of cooling also in fresh semen. Vigor, total (TM) and progressive motility (PM) were also evaluated after thermoresistance test (TTR), in the absence and presence of peroxide. TM, PM, sperm vigor and MTT were similar (P > 0.05) between NAC concentrations at 24 and 48 h. The response to HOST was similar between NAC concentrations (P > 0.05) at 24 h cooling, but at 48 h there was a decreased in membrane functionality in 2.5mM NAC group compared to the EQUIDIL group. TM, PM, and vigor of the samples cooled by 24 h and submitted to TTR differed between without and with peroxide (P< 0.05) in the EQUIDIL, 0.5mM and 1.0mM groups, but was similar in 2.5mM NAC. After cooling for 48 h, there was difference in vigor and TM between samples with and without peroxide (P < 0.05) in all groups tested, but the PM was similar between samples with and without peroxide at concentration 2.5mM of NAC. The pH of the EQUIDIL extender was higher and the EQUIDIL + 0.5mM and 1.0mM groups had intermediate values, while the 2.5mM NAC concentration generated lower values in the three evaluated periods (P < 0.05). There was no significant variation of pH between 0 and 24 h (P=0.7075) and between 0 and 48 h (P=0.4617) in all groups tested. The concentrations of NAC tested did not improve motility, plasma membrane integrity, mitochondrial activity and response to HOST equine spermatozoa cooled to 5°C and stored for 48 h. After TTR, the concentrations of NAC tested did not prevent the decrease of motility and sperm vigor in the presence of peroxide.

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Kerksick, Chad M. Willoughby Darryn Scott. "Effects of prophylactic supplementation of N-acetyl-cysteine and epigallocatechin gallate on markers of oxidative stress, inflammation and apoptosis after eccentric contraction-induced injury in untrained males." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4881.

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Nocentini, Benedetta. "Indagine su reazioni di sulfa-Michael di interesse in campo cosmetologico e sul trattamento ricostruttore del capello." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15849/.

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The aim of this work was to evaluate the reactivity of cysteinyl residues that can be found in damaged human hair with Michael acceptors under mild conditions and to gain information on the hair modifications occurring in hair bleached and then repaired with some commercial formulations. In some patents, the use of some molecules effective for repairing damaged hair is claimed. Their structure is compatible with the occurrence of Michael addition reactions, and the need of more detailed studies about the reaction mechanism and the effect on human hair of commercial products containing hair rebuilding agents has inspired this study. First, the investigation was focused to find Michael acceptors alternative to those claimed by the examined patents. As model reaction N-acetyl-L-cysteine was chosen as nucleophilic agent and different electrophiles, such as quinone- and maleic acid- derivatives, as well as a,b-unsatured ketones and esters were used. Subsequently we investigated, through Raman/IR spectroscopy and electronic scanning microscopy (SEM), on the effect of hair treatment with Michael acceptors studied in the first part and also some commercial hair rebuilding formulations.

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Barbanera, Pedro Octavio. "Estudo do efeito do N-acetil-cisteína através do metabolismo energético, complexos respiratórios e estresse oxidativo no tecido hepático de ratos submetidos ao glutamato monossódico." Botucatu, 2018. http://hdl.handle.net/11449/158323.

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Orientador: Ana Angélica Henrique Fernandes
Resumo: A obesidade é considerada um dos maiores problemas de saúde pública em muitos países, uma vez que está associada queda da qualidade de vida. Embora existam vários fatores que corroboram com o desenvolvimento para tal fato, os hábitos alimentares seja o fator relevante. Os transtornos metabólicos podem resultar em alterações na funcionalidade do fígado, podendo desenvolver Doença Hepática Gordurosa Não Alcoólica (DHGNA). Como o número de obesos e as co-morbidades associadas ao sobrepeso vêm aumentando abruptamente nas últimas décadas, vários modelos de obesidade experimental têm sido propostos para investigar os distúrbios metabólicos envolvendo suas causas e consequências. O glutamato monossódico é amplamente utilizado na culinária e também por indústrias alimentícias, contudo atua no sistema nervoso central e promove a degeneração de áreas importantes do hipotálamo que leva a distúrbios da saciedade e, consequentemente acúmulo excessivo de gordura abdominal. Com a finalidade de estudar substâncias que apresentem potencial atividade terapêutica no controle dos distúrbios metabólicos, o N-acetil-cisteína possui propriedades antioxidantes e exerce hepatoproteção. Desta forma, o objetivo do presente estudo foi evidenciar a indução da obesidade pelo glutamato monossódico e determinar o efeito do N-acetil-cisteína sobre os parâmetros calorimétricos, metabolismo energético, atividade dos complexos respiratórios e estresse oxidativo no tecido hepático. Foram utilizados 32 ratos Wins... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Obesity is considered one of the greatest public health problems in many countries, since it is associated with a drop in quality of life. Although there are several factors corroborating with the development for this fact, eating habits are the relevant factor. Metabolic disorders can result in changes in liver function, and can develop Non-Alcoholic Fatty Liver Disease (NAFLD). As the number of obese and co-morbidities associated with overweight have increased steeply in recent decades, several models of experimental obesity have been proposed to investigate metabolic disorders involving their causes and consequences. Monosodium glutamate is widely used in cooking and also in food industries, but it acts on the central nervous system and promotes the degeneration of important areas of the hypothalamus which leads to satiety disorders and consequently excessive accumulation of abdominal fat. In order to study substances that present potential therapeutic activity in the control of metabolic disorders, N-acetyl-cysteine has antioxidant properties and exerts hepatoprotection. Thus, the objective of the present study was to evidence the induction of obesity by monosodium glutamate and to determine the effect of Nacetyl-cysteine on calorimetric parameters, energy metabolism, respiratory complex activity and oxidative stress in hepatic tissue. Thirty-two Winstar male mice were used at 21 days of age. Initially the animals were distributed in two experimental groups (n = 16). Grou... (Complete abstract click electronic access below)
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Ibrahim, Marwa Awad Abdel Hamid [Verfasser]. "Immunohistochemical studies of the influence of alkylating substances on the wound healing process and the possible protective role of N-Acetyl Cysteine and Alpha-Linolenic Acid / Marwa Awad Abdel Hamid Ibrahim." Köln : Deutsche Zentralbibliothek für Medizin, 2012. http://d-nb.info/1030211507/34.

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Books on the topic "Cysteine, N-acetyl Cysteine"

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Hitt, Mark Edward. Hepatocellular cytoprotection against the pathobiologic effects of thiacetarsamine in vitro and in vivo using N-acetyl-L-cysteine. Ottawa: National Library of Canada, 1992.

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Hitt, Mark Edward. Hepatocellular cytoprotection against the pathobiologic effects of thiacetarsamine in vitro and in vivo using N-acetyl-L-cysteine. Charlottetown: University of Prince Edward Island, 1992.

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Publications, ICON Health. N-Acetyl Cysteine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

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Buttram, Sandra D. W., and Anne-Michelle Ruha. Toxicological Emergencies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0017.

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Abstract:

This chapter includes essential information about common toxic exposures requiring pediatric intensive care unit care. Specific agents, grouped into categories, are reviewed, including analgesics (acetaminophen and aspirin), opiates, carbon monoxide, cardiovascular medications (calcium channel antagonists and β‎ blockers), tricyclic antidepressants, sulfonylureas, and toxic alcohols. An overview of each agent followed by clinical presentation, and appropriate diagnostic evaluation and management are provided, including alkalinization with administration of sodium bicarbonate, need for hemodialysis, and use of specific antidotes (e.g., naloxone, n-acetyl cysteine, glucagon, fomepizole).

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Book chapters on the topic "Cysteine, N-acetyl Cysteine"

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Pannu, Neesh, Xiaoyan Wen, John A. Kellum, John Fildes, N. Al-Subaie, Mark Hamilton, Susan M. Lareau, et al. "N-Acetyl Cysteine (Renal)." In Encyclopedia of Intensive Care Medicine, 1507–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_304.

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Agustí, A. G. N., J. Ibañez, and B. Togores. "Effects of N-Acetyl-Cysteine on Splanchnic Circulation." In Update in Intensive Care and Emergency Medicine, 39–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79715-6_4.

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De Flora, Silvio, Alberto Izzotti, Adriana Albini, Francesco D’Agostini, Maria Bagnasco, and Roumen Balansky. "Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine." In Cancer Chemoprevention, 37–67. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-767-3_3.

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Sato, Naoko, Takeshi Ueno, Katsutoshi Kubo, Takeo Suzuki, Naoki Tsukimura, Keiichi Sasaki, and Takahiro Ogawa. "Inhibition of oral fibroblast growth and function by N-acetyl cysteine." In Interface Oral Health Science 2009, 140–42. Tokyo: Springer Japan, 2010. http://dx.doi.org/10.1007/978-4-431-99644-6_25.

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Olivier, R., O. Lopez, M. Mollereau, T. Dragic, D. Guetard, and L. Montagnier. "Prevention of early cell death in peripheral blood lymphocytes of HIV infected individuals by an anti-oxidant: N-Acetyl-Cysteine." In Oxidative Stress, Cell Activation and Viral Infection, 323–32. Basel: Birkhäuser Basel, 1994. http://dx.doi.org/10.1007/978-3-0348-7424-3_27.

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Abdel-Baky, Rehab Mahmoud, Mohamed Abdullah Ali, Gamal El-Din Ali A. Abuo-Rahma, and Neveen AbdelAziz. "Inhibition of Urease Enzyme Production and some Other Virulence Factors Expression in Proteus mirabilis by N-Acetyl Cysteine and Dipropyl Disulphide." In Advances in Experimental Medicine and Biology, 99–113. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/5584_2016_197.

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Clough, Stephen R. "Cysteine, N-Acetyl-L*." In Encyclopedia of Toxicology, 716–18. Elsevier, 2005. http://dx.doi.org/10.1016/b0-12-369400-0/00286-6.

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Clough, S. R. "Cysteine, N-Acetyl-l." In Encyclopedia of Toxicology, 1122–24. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-386454-3.00485-1.

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Coricovac, Dorina E., Iulia A. Pinzaru, and Cristina A. Dehelean. "N-acetyl-l-cysteine." In Reference Module in Biomedical Sciences. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-12-824315-2.01155-6.

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Ackert-Bicknell, Cheryl L., Wesley G. Beamer, and Clifford J. Rosen. "N-Acetyl Cysteine Supplementation of Growing Mice." In Nutritional Aspects of Osteoporosis, 369–77. Elsevier, 2004. http://dx.doi.org/10.1016/b978-012141704-8/50065-9.

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Conference papers on the topic "Cysteine, N-acetyl Cysteine"

1

Lin, Chih-Ju, Feng-Chieh Li, Sheng-Shun Wang, Hsuan-Shu Lee, and Chen-Yuan Dong. "In Vivo N-Acetyl Cysteine Reduce Hepatocyte Death by Induced Acetaminophen." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/ecbo.2011.80921l.

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Lin, Chih-Ju, Feng-Chieh Li, Sheng-Shun Wang, Hsuan-Shu Lee, and Chen-Yuan Dong. "In vivo N-acetyl cysteine reduce hepatocyte death by induced acetaminophen." In European Conferences on Biomedical Optics, edited by Ronald Sroka and Lothar D. Lilge. SPIE, 2011. http://dx.doi.org/10.1117/12.889621.

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Longo, Angela, Gianfranco Carotenuto, and Sergio De Nicola. "Synthesis of luminescent gold nano-clusters coated by N-acetyl-L-cysteine." In 2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2015. http://dx.doi.org/10.1109/nano.2015.7388663.

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Brown, Michael D., Matthew T. Hardison, J. E. Blalock, and Patricia L. Jackson. "Inhibition Of Acetylation Of The PMN Chemoattractant Peptide PGP By Carbocysteine And N-Acetyl Cysteine." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2564.

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Dave, B., S. Granados, S. Mitra, and JC Chang. "Abstract P5-03-12: Targeting breast cancer stem cells using the autopahgy inhibitor N-Acetyl cysteine." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p5-03-12.

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Shah, Parth N., Andrew R. Mullen, Ralph J. DeBerardinis, and Carolyn L. Cannon. "Amelioration Of Cytotoxic And Metabolic Effects Of Silver Cations On Respiratory Epithelial Cells By N-Acetyl Cysteine." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3260.

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Gotera Rivera, C. M., C. López Chang, L. De La Dueña, L. Llanos Jiménez, R. Cortés, O. Sánchez Pernaute, C. Pérez Calvo, et al. "Effect of N-acetyl cysteine in a patient cohort with severe or very severe COVID-19 pneumonia." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.4675.

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Kim, HR, BM Kim, KA Lee, SH Lee, and KW Kim. "114 N-acetyl-l-cysteine (NAC) controls osteoclastogenesis through regulating th17 differentiation and rankl production in rheumatoid arthritis." In LUPUS 2017 & ACA 2017, (12th International Congress on SLE &, 7th Asian Congress on Autoimmunity). Lupus Foundation of America, 2017. http://dx.doi.org/10.1136/lupus-2017-000215.114.

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Kim, H.-R., K.-A. Lee, and S.-H. Lee. "AB0090 N-ACETYL-L-CYSTEINE (NAC) controls osteoclastogenesis through regulating TH17 differentiation and RANKL production in rheumatoid arthritis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1506.

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Budhathoki, P., Y. R. Sedhai, D. B. Shrestha, R. Baniya, B. D. Pathak, O. P. Tandon, P. Thapa, and P. Prasai. "N-Acetyl Cysteine with Steroid Versus Steroid Alone in Severe Alcoholic Hepatitis: A Systematic Review and Meta-Analysis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2579.

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