Journal articles on the topic 'Cyp24a1 knockout'
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Scherler, Laeticia, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, and Geneviève Escher. "Adenine-Induced Nephropathy Reduces Atherosclerosis in ApoE Knockout Mice." Biomolecules 12, no. 8 (August 19, 2022): 1147. http://dx.doi.org/10.3390/biom12081147.
Full textYasuda, Kaori, Miyu Nishikawa, Kairi Okamoto, Kyohei Horibe, Hiroki Mano, Mana Yamaguchi, Risa Okon, et al. "Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system." Journal of Biological Chemistry 296 (January 2021): 100668. http://dx.doi.org/10.1016/j.jbc.2021.100668.
Full textChristakos, Sylvia, Puneet Dhawan, Annemieke Verstuyf, Lieve Verlinden, and Geert Carmeliet. "Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects." Physiological Reviews 96, no. 1 (January 2016): 365–408. http://dx.doi.org/10.1152/physrev.00014.2015.
Full textGirgis, Christian M., Nancy Mokbel, Kuan Minn Cha, Peter J. Houweling, Myriam Abboud, David R. Fraser, Rebecca S. Mason, Roderick J. Clifton-Bligh, and Jenny E. Gunton. "The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers." Endocrinology 155, no. 9 (September 1, 2014): 3227–37. http://dx.doi.org/10.1210/en.2014-1016.
Full textKurihara, Noriyoshi, Yukiko Kitagawa, Yuji Inagaki, Jolene J. Windle, John M. Chirgwin, and G. David Roodman. "TAF12 Enhances the Biological Reponses of Myeloma Cells to Low Concentrations of 1,25-(OH)2dvitamin D3." Blood 124, no. 21 (December 6, 2014): 2066. http://dx.doi.org/10.1182/blood.v124.21.2066.2066.
Full textKono, Hiroshi, Blair U. Bradford, Ming Yin, Kathleen K. Sulik, Dennis R. Koop, Jeffrey M. Peters, Frank J. Gonzalez, et al. "CYP2E1 is not involved in early alcohol-induced liver injury." American Journal of Physiology-Gastrointestinal and Liver Physiology 277, no. 6 (December 1, 1999): G1259—G1267. http://dx.doi.org/10.1152/ajpgi.1999.277.6.g1259.
Full textSnyder, Jessica M., Guo Zhong, Cathryn Hogarth, Weize Huang, Traci Topping, Jeffrey LaFrance, Laura Palau, et al. "Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice." FASEB Journal 34, no. 12 (October 26, 2020): 15788–804. http://dx.doi.org/10.1096/fj.202001734r.
Full textZong, Haihong, Michal Armoni, Chava Harel, Eddy Karnieli, and Jeffrey E. Pessin. "Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance." American Journal of Physiology-Endocrinology and Metabolism 302, no. 5 (March 1, 2012): E532—E539. http://dx.doi.org/10.1152/ajpendo.00258.2011.
Full textEscher, Geneviève, Isabelle Vögeli, Robert Escher, Robert C. Tuckey, Sandra Erickson, Zygmunt Krozowski, and Felix J. Frey. "Role of CYP27A1 in progesterone metabolism in vitro and in vivo." American Journal of Physiology-Endocrinology and Metabolism 297, no. 4 (October 2009): E949—E955. http://dx.doi.org/10.1152/ajpendo.00298.2009.
Full textDing, Lili, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M. Sousa, Bingning Dong, Yangmeng Wang, et al. "Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice." Proceedings of the National Academy of Sciences 118, no. 6 (February 1, 2021): e2019388118. http://dx.doi.org/10.1073/pnas.2019388118.
Full textZurkinden, Line, Yosef T. Mansour, Beatrice Rohrbach, Bruno Vogt, Hiten D. Mistry, and Geneviève Escher. "Hepatic caveolin‐1 is enhanced in Cyp27a1/ApoE double knockout mice." FEBS Open Bio 6, no. 10 (September 26, 2016): 1025–35. http://dx.doi.org/10.1002/2211-5463.12123.
Full textZurkinden, Line, Curzio Solca, Isabelle A. Vögeli, Bruno Vogt, Daniel Ackermann, Sandra K. Erickson, Felix J. Frey, Dmitri Sviridov, and Geneviève Escher. "Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE‐knockout mice." FASEB Journal 28, no. 3 (December 10, 2013): 1198–209. http://dx.doi.org/10.1096/fj.13-233791.
Full textMacLean, Glenn, Hui Li, Daniel Metzger, Pierre Chambon, and Martin Petkovich. "Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice." Endocrinology 148, no. 10 (October 1, 2007): 4560–67. http://dx.doi.org/10.1210/en.2007-0492.
Full textReinke, Daniel C., Masakazu Kogawa, Kate R. Barratt, Howard A. Morris, Paul H. Anderson, and Gerald J. Atkins. "Evidence for altered osteoclastogenesis in splenocyte cultures from Cyp27b1 knockout mice." Journal of Steroid Biochemistry and Molecular Biology 164 (November 2016): 353–60. http://dx.doi.org/10.1016/j.jsbmb.2015.11.015.
Full textCorreia, Maria Almira, and Doyoung Kwon. "Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models." Biology 9, no. 12 (November 26, 2020): 419. http://dx.doi.org/10.3390/biology9120419.
Full textAlhasson, Firas, Diptadip Dattaroy, Suvarthi Das, Varun Chandrashekaran, Ratanesh Kumar Seth, Rick G. Schnellmann, and Saurabh Chatterjee. "NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity." American Journal of Physiology-Renal Physiology 310, no. 1 (January 1, 2016): F85—F101. http://dx.doi.org/10.1152/ajprenal.00243.2015.
Full textRowling, Matthew J., Christy Gliniak, JoEllen Welsh, and James C. Fleet. "High Dietary Vitamin D Prevents Hypocalcemia and Osteomalacia in CYP27B1 Knockout Mice." Journal of Nutrition 137, no. 12 (December 1, 2007): 2608–15. http://dx.doi.org/10.1093/jn/137.12.2608.
Full textLangton, Simne, and Lorraine J. Gudas. "CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid." Developmental Biology 315, no. 2 (March 2008): 331–54. http://dx.doi.org/10.1016/j.ydbio.2007.12.021.
Full textZurkinden, L., D. Sviridov, S. K. Erickson, B. Vogt, and G. Escher. "701 EFFECT OF HEPATIC CYP7A1 AND CYP3A11 MODULATION ON ATHEROSCLEROSIS IN cyp27A1/apoE DOUBLE KNOCKOUT MICE." Journal of Hepatology 58 (April 2013): S284. http://dx.doi.org/10.1016/s0168-8278(13)60703-5.
Full textHirota, Yoshihisa, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, and Toshio Okano. "Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice." PLOS ONE 13, no. 10 (October 3, 2018): e0199856. http://dx.doi.org/10.1371/journal.pone.0199856.
Full textYe, Huanying, Danjuan Sui, Wei Liu, Yuannan Yuan, Zhen Ouyang, and Yuan Wei. "Effects of CYP2C11 gene knockout on the pharmacokinetics and pharmacodynamics of warfarin in rats." Xenobiotica 49, no. 12 (February 27, 2019): 1478–84. http://dx.doi.org/10.1080/00498254.2019.1579006.
Full textWu, Di, Mingjuan Gu, Zhuying Wei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Lei Yang, and Guangpeng Li. "Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle." Animals 12, no. 2 (January 15, 2022): 205. http://dx.doi.org/10.3390/ani12020205.
Full textKovacs, Werner J., Janis E. Shackelford, Khanichi N. Tape, Michael J. Richards, Phyllis L. Faust, Steven J. Fliesler, and Skaidrite K. Krisans. "Disturbed Cholesterol Homeostasis in a Peroxisome-Deficient PEX2 Knockout Mouse Model." Molecular and Cellular Biology 24, no. 1 (January 1, 2004): 1–13. http://dx.doi.org/10.1128/mcb.24.1.1-13.2004.
Full textChen, Xue, Stephen C. Ward, Arthur I. Cederbaum, Huabao Xiong, and Yongke Lu. "Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis." Toxicology 379 (March 2017): 12–21. http://dx.doi.org/10.1016/j.tox.2017.01.016.
Full textALHASSON, FIRAS A., SUVARTHI DAS, Varun Chandrashekaran, Diptadip Dattaroy, Ratanesh Kumar Seth, Mitzi Nagarkatti, Prakash Nagarkatti, and Saurabh Chatterjee. "Adipokine Leptin mediated NOX-2 promotes kidney inflammation in nonalcoholic fatty liver disease via miR21-dependent mesangial cell immune activation." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 197.16. http://dx.doi.org/10.4049/jimmunol.198.supp.197.16.
Full textNishikawa, Miyu, Kaori Yasuda, Masashi Takamatsu, Keisuke Abe, Kimie Nakagawa, Naoko Tsugawa, Yoshihisa Hirota, et al. "Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes." Journal of Steroid Biochemistry and Molecular Biology 185 (January 2019): 71–79. http://dx.doi.org/10.1016/j.jsbmb.2018.07.012.
Full textFarhan, Fahad, Mohammad Almarhoun, Aileen Wong, Amy S. Findlay, Chris Bartholomew, Mark T. S. Williams, Toby W. Hurd, and Xinhua Shu. "Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina." Cells 10, no. 11 (November 7, 2021): 3066. http://dx.doi.org/10.3390/cells10113066.
Full textHirota, Yoshihisa, Kimie Nakagawa, Shino Mimatsu, Natsumi Sawada, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naoko Tsugawa, Yoshitomo Suhara, and Toshio Okano. "Nongenomic effects of 1α,25-dihydroxyvitamin D 3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice." Biochemical and Biophysical Research Communications 483, no. 1 (January 2017): 359–65. http://dx.doi.org/10.1016/j.bbrc.2016.12.139.
Full textSong, Yurong, and James C. Fleet. "Intestinal Resistance to 1,25 Dihydroxyvitamin D in Mice Heterozygous for the Vitamin D Receptor Knockout Allele." Endocrinology 148, no. 3 (March 1, 2007): 1396–402. http://dx.doi.org/10.1210/en.2006-1109.
Full textJia, Lin, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, and Liqing Yu. "NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice." Cells 10, no. 12 (December 9, 2021): 3468. http://dx.doi.org/10.3390/cells10123468.
Full textChhetri, Goma, Yanyan Liang, Juntang Shao, Dan Han, Yi Yang, Chao Hou, Peng Wang, et al. "Role of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Alcohol-Induced Liver Injury." Oxidative Medicine and Cellular Longevity 2020 (July 7, 2020): 1–15. http://dx.doi.org/10.1155/2020/9034864.
Full textLei, Xin Gen, Jian-Hong Zhu, James P. McClung, Manuel Aregullin, and Carol A. Roneker. "Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity." Biochemical Journal 399, no. 3 (October 13, 2006): 455–61. http://dx.doi.org/10.1042/bj20060784.
Full textKiourtzidis, Mikis, Julia Kühn, Corinna Brandsch, and Gabriele I. Stangl. "Vitamin D Status of Mice Deficient in Scavenger Receptor Class B Type 1, Cluster Determinant 36 and ATP-Binding Cassette Proteins G5/G8." Nutrients 12, no. 8 (July 22, 2020): 2169. http://dx.doi.org/10.3390/nu12082169.
Full textJeong, Jae-Wook, Kevin Y. Lee, Inseok Kwak, Lisa D. White, Susan G. Hilsenbeck, John P. Lydon, and Francesco J. DeMayo. "Identification of Murine Uterine Genes Regulated in a Ligand-Dependent Manner by the Progesterone Receptor." Endocrinology 146, no. 8 (August 1, 2005): 3490–505. http://dx.doi.org/10.1210/en.2005-0016.
Full textNarvaez, Carmen J., Donald Matthews, Emily Broun, Michelle Chan, and JoEllen Welsh. "Lean Phenotype and Resistance to Diet-Induced Obesity in Vitamin D Receptor Knockout Mice Correlates with Induction of Uncoupling Protein-1 in White Adipose Tissue." Endocrinology 150, no. 2 (February 1, 2009): 651–61. http://dx.doi.org/10.1210/en.2008-1118.
Full textPinterić, Marija, Iva I. Podgorski, Marijana Popović Hadžija, Ivana Tartaro Bujak, Ana Dekanić, Robert Bagarić, Vladimir Farkaš, Sandra Sobočanec, and Tihomir Balog. "Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet in Mice." Antioxidants 9, no. 2 (February 20, 2020): 174. http://dx.doi.org/10.3390/antiox9020174.
Full textXu, Jin, Yi Peng, Yi Zeng, Yi-qiao Hua, and Xiao-le Xu. "2, 3, 4′, 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms." International Journal of Molecular Sciences 20, no. 7 (April 1, 2019): 1617. http://dx.doi.org/10.3390/ijms20071617.
Full textArora, Juhi, Devanshi R. Patel, McKayla J. Nicol, Cassandra J. Field, Katherine H. Restori, Jinpeng Wang, Nicole E. Froelich, et al. "Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs." Nutrients 14, no. 15 (July 26, 2022): 3061. http://dx.doi.org/10.3390/nu14153061.
Full textZinser, Glendon M., and JoEllen Welsh. "Accelerated Mammary Gland Development during Pregnancy and Delayed Postlactational Involution in Vitamin D3 Receptor Null Mice." Molecular Endocrinology 18, no. 9 (September 1, 2004): 2208–23. http://dx.doi.org/10.1210/me.2003-0469.
Full textTeodorescu, Patric, Yuya Nagai, Guo Zhong, Vikram Mathews, Nina Isoherranen, and Gabriel Ghiaur. "Arsenic Trioxide Reprograms the Bone-Marrow Microenvironment to Sensitize Minimal Residual Disease in Acute Myeloid Leukemia." Blood 138, Supplement 1 (November 5, 2021): 1166. http://dx.doi.org/10.1182/blood-2021-153244.
Full textAlonso, Salvador, William Matsui, Richard J. Jones, and Gabriel Ghiaur. "Bone Marrow Niche - Multiple Myeloma Cross-Talk Generates Bortezomib Resistance." Blood 126, no. 23 (December 3, 2015): 914. http://dx.doi.org/10.1182/blood.v126.23.914.914.
Full textUeda, Hajime, Akira Honda, Teruo Miyazaki, Yukio Morishita, Takeshi Hirayama, Junichi Iwamoto, Nobuhiro Nakamoto, and Tadashi Ikegami. "Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition." PLOS ONE 17, no. 7 (July 12, 2022): e0271308. http://dx.doi.org/10.1371/journal.pone.0271308.
Full textArul, Glancis Luzeena Raja, Ezequiel Tolosa, Ryan M. Carr, and Martin E. Fernandez-Zapico. "Abstract B002: Modeling evolutionary therapy for GI malignancies." Cancer Research 82, no. 10_Supplement (May 15, 2022): B002. http://dx.doi.org/10.1158/1538-7445.evodyn22-b002.
Full textSigurdsson, Valgardur, Hajime Takei, Svetlana Soboleva, Takashi Iida, Hiroshi Nittono, and Kenichi Miharada. "Taurine-Conjugated Bile Acids Protect Expanding Hematopoietic Stem/Progenitor Cells from Unfolded Protein Stress As Natural Chaperones." Blood 124, no. 21 (December 6, 2014): 4318. http://dx.doi.org/10.1182/blood.v124.21.4318.4318.
Full textIlenwabor, Barnabas P., Heidi Schigt, Andreas Kompatscher, Caro Bos, Malou Zuidscherwoude, Bram C. J. van der Eerden, Joost G. J. Hoenderop, and Jeroen H. F. de Baaij. "FAM111A is dispensable for electrolyte homeostasis in mice." Scientific Reports 12, no. 1 (June 17, 2022). http://dx.doi.org/10.1038/s41598-022-14054-8.
Full textNishikawa, Miyu, Kaori Yasuda, Hiroki Mano, Shinichi Ikushiro, and Toshiyuki Sakaki. "Generation of Genetically Modified Rats Using CRISPR/Cas9 Genome-Editing System to Reveal Novel Vitamin D Actions." Medical Research Archives 9, no. 9 (2021). http://dx.doi.org/10.18103/mra.v9i9.2558.
Full textJi, Wen-Heng, Dan-Dan Li, Dan-Ping Wei, Ai-Qin Gu, Ying Yang, and Jing-Pian Peng. "Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period." Frontiers in Immunology 12 (October 12, 2021). http://dx.doi.org/10.3389/fimmu.2021.763067.
Full textPaul, Bidisha, Leena H. Shewade, and Daniel R. Buchholz. "cyp21a2 knockout tadpoles survive metamorphosis despite low corticosterone." Endocrinology, October 27, 2022. http://dx.doi.org/10.1210/endocr/bqac182.
Full textZurkinden, Line, Dmitri Sviridov, Bruno Vogt, and Geneviève Escher. "Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice." Bioscience Reports 38, no. 1 (January 25, 2018). http://dx.doi.org/10.1042/bsr20171162.
Full textLi, Se-Ruo, Zhu-Xia Tan, Yuan-Hua Chen, Biao Hu, Cheng Zhang, Hua Wang, Hui Zhao, and De-Xiang Xu. "Vitamin D deficiency exacerbates bleomycin-induced pulmonary fibrosis partially through aggravating TGF-β/Smad2/3-mediated epithelial-mesenchymal transition." Respiratory Research 20, no. 1 (November 27, 2019). http://dx.doi.org/10.1186/s12931-019-1232-6.
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