Academic literature on the topic 'CYP199A4'
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Journal articles on the topic "CYP199A4"
Chao, Rebecca R., James J. De Voss, and Stephen G. Bell. "The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4." RSC Advances 6, no. 60 (2016): 55286–97. http://dx.doi.org/10.1039/c6ra11025h.
Full textColeman, Tom, Rebecca R. Chao, John B. Bruning, James J. De Voss, and Stephen G. Bell. "CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives." RSC Advances 5, no. 64 (2015): 52007–18. http://dx.doi.org/10.1039/c5ra08730a.
Full textFaletrov, Y. V., V. O. Maliugin, N. S. Frolova, and V. M. Shkumatov. "<i>In silico</i> evaluation of new affine interactions of methylcoumarin with cytochromes P450." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 58, no. 2 (June 8, 2022): 186–90. http://dx.doi.org/10.29235/1561-8331-2022-58-2-186-190.
Full textBell, Stephen G., Wen Yang, Adrian B. H. Tan, Ruimin Zhou, Eachan O. D. Johnson, Aili Zhang, Weihong Zhou, Zihe Rao, and Luet-Lok Wong. "The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site." Dalton Transactions 41, no. 28 (2012): 8703. http://dx.doi.org/10.1039/c2dt30783a.
Full textBell, Stephen G., Adrian B. H. Tan, Eachan O. D. Johnson, and Luet-Lok Wong. "Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2." Mol. BioSyst. 6, no. 1 (2009): 206–14. http://dx.doi.org/10.1039/b913487e.
Full textColeman, Tom, Siew Hoon Wong, Matthew N. Podgorski, John B. Bruning, James J. De Voss, and Stephen G. Bell. "Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris Catalyzes Heteroatom Dealkylations, Sulfoxidation, and Amide and Cyclic Hemiacetal Formation." ACS Catalysis 8, no. 7 (May 17, 2018): 5915–27. http://dx.doi.org/10.1021/acscatal.8b00909.
Full textColeman, Tom, Rebecca R. Chao, James J. De Voss, and Stephen G. Bell. "The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864, no. 6 (June 2016): 667–75. http://dx.doi.org/10.1016/j.bbapap.2016.03.006.
Full textVanselow, Jens, Alan J. Conley, Cynthia J. Corbin, and Trish Berger. "Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog." Genes 12, no. 4 (April 6, 2021): 533. http://dx.doi.org/10.3390/genes12040533.
Full textBell, Stephen G., Ruimin Zhou, Wen Yang, Adrian B. H. Tan, Alexander S. Gentleman, Luet-Lok Wong, and Weihong Zhou. "Investigation of the Substrate Range of CYP199A4: Modification of the Partition between Hydroxylation and Desaturation Activities by Substrate and Protein Engineering." Chemistry - A European Journal 18, no. 52 (November 7, 2012): 16677–88. http://dx.doi.org/10.1002/chem.201202776.
Full textKazeto, Yukinori, Shigeho Ijiri, Allen R. Place, Yonathan Zohar, and John M. Trant. "The 5′-Flanking Regions of CYP19A1 and CYP19A2 in Zebrafish." Biochemical and Biophysical Research Communications 288, no. 3 (November 2001): 503–8. http://dx.doi.org/10.1006/bbrc.2001.5796.
Full textDissertations / Theses on the topic "CYP199A4"
Youn, Jin Young. "Polymorphisms of FSHR, ESR and CYP19A1 and ovarian stimulation outcome." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31627.
Full textPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Ovarian stimulation is frequently used in many assisted reproductive technologies (ART) procedures to increase the number of dominant follicles. However, achieving the optimal response to ovarian stimulation without complications can be difficult. In our study, we predict that future ovarian stimulation procedures will be more individually catered to each patient. A study that established a predictor model for ovarian stimulation showed that genetic single nucleotide polymorphisms (SNP) are good predictive factors (Fauser et al., 2007). Thus the objective of this study was to determine if there was any association between the various parameters that measure the success of ovarian stimulation and FSHR, CYP19, ESRJ and ESR2 singe nucleotide polymorphisms (SNP). A total of two hundred and four women undergoing either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were genotyped to study the distribution of the different SNPs. Complete clinical information was available for a range of forty nine to seventy three women to study any association between genotype and basal FSH level (day 3), basal 17 -beta estradiol level, number of follicles, number of eggs and the level of 17-beta estradiol during hCG administration. The association was studied using the one way ANOVA test and linear regression model. There was a significant correlation between the CYP 19Al rs10046 genotypes and FSH level (p=0.004), number of follicles (p=0.03) and level of 17-beta estradiol during hCG administration (p=0.04). Also, FSHR rs2268263 genotype was significantly linked to FSH level between the G-allele group (A/G and G/G) and the homozygote A group (p=0.04). Taken all together, these results suggest that several genes-especially CYP 19AJ and FSHR rs2269263- play a significant role in determining the success of ovarian stimulation.
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Escobar, Gabriela Fortes. "Polimorfismos genéticos dos genes CYP19A1 e NFKB1 e o risco de melanoma cutâneo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/116777.
Full textAbreu, Lauriane Giselle de. "Expressão do gene da aromatase (CYP19A1) nas células da granulosa murais luteinizadas de mulheres com endometriose submetidas a técnicas de reprodução assistida." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-27092013-094914/.
Full textBackground: Up to 60% of women with endometriosis have infertility symptoms. However, mechanisms remain unclear, mainly when there is no distortion of pelvic anatomy. The multifactorial etiology and polygenic involvement of this disease have been widely accepted. Aromatase is one of the most studied molecules and there are evidences of increased expression of its gene (CYP19A1) on eutopic and ectopic endometrium in endometriosis. This enzyme, codified by the CYP19A1 gene, converts androgens to estrogens and is normally present in granulosa cells, where it plays an essential role for the intrafollicle steroidogenic production. In vitrostudies by granulosa cells culture have demonstrated reduced aromatase activity in women with endometriosis. The scarcity of studies assessing expression of the aromatase gene (CYP19A1) on these target cells stimulated the proposal of this research. The aim of this study is to quantify aromatase gene expression, by real-time PCR, in mural lutein-granulose cells of women with endometriosis undergoing assisted reproduction techniques. Patients and Methods: a case-control study was conducted on 11 women with endometriosis and 11 with male or tubal causes of infertility submitted to ovarian hyperstimulation (HOC), with a total of 12 cycles for endometriosis and 11 for the control group. There was no difference between the groups regarding age or HOC parameters. Mural lutein-granulosacells were harvested from pre-ovulatory follicles during oocyte retrieval and properly isolated. Later, RNA extraction (clorophorm/isopropanol) and reverse transcription were performed. Real-time PCR was run to quantify RNAm products of aromatase gene normalized to those from the control gene, beta-actin (relative expression). All experiments were carried out in duplicate. Results: there was no difference between the groups regarding the gene expression of CYP19A1 (aromatase) gene on mural lutein-granulosa cells (p>0.05, Mann Whitney), even if we consider separately the different stages of endometriosis (control vs. minimal/mild vs. moderate/severe, p>0.05, Kruskall Wallis). Conclusion: These results suggest that aromatase may have a complex control of its gene expression on granulosa cells and, despite of previous evidences showing its reduced activity on these target cells in endometriosis, the gene expression seems not affected by the disease, according to this study.
Viciano, Gonzalo Ignacio. "A theoretical study on the mechanism of the oxidation of substrates by human aromatase enzyme (CYP19A1)." Doctoral thesis, Universitat Jaume I, 2016. http://hdl.handle.net/10803/392148.
Full textLa enzima citocromo P450 aromatasa juega un papel esencial en la biosíntesis de estrógenos, y su inhibición es un objetivo importante para el desarrollo de medicamentos para el tratamiento del cáncer de mama. El objetivo principal de la esta Tesis ha sido arrojar luz sobre el mecanismo catalítico y sobre la bioquímica de esta enzima, desde el punto de vista de la química teórica. Los resultados que se presentan en esta Tesis se han dividido en tres secciones principales: (1) Estudio de la especie reactiva de la enzima aromatasa: "Compound I"; (2) Estudio de la hidroxilación del substrato natural androstenediona, a lo largo del primer subciclo catalítico de esta enzima; y (3) Estudio de la hidroxilación del Exemestano, un inhibidor esteroideo de tercera generación de la enzima aromatasa, que se utiliza actualmente en el tratamiento del cáncer de mama hormonodependiente.
Reuter, Benoit [Verfasser], and Peter [Gutachter] Fasching. "Genetische Polymorphismen im Aromatasegen (CYP19A1) und deren Assoziation mit dem Geburtsgewicht des Kindes / Benoit Reuter ; Gutachter: Peter Fasching." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1143231996/34.
Full textSchmid, Heidi. "" Aromatase and the Pharmacogenomic Profile - Influence of CYP19A1 polymorphisms in the response of breast cancer patients treated with aromatase inhibitors"." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/57191.
Full textSchmid, Heidi. "" Aromatase and the Pharmacogenomic Profile - Influence of CYP19A1 polymorphisms in the response of breast cancer patients treated with aromatase inhibitors"." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/57191.
Full textNunes, Marília Danyelle. "Análise do polimorfismo nos genes CYP19a e CYP19b em Oreochromis niloticus da linhagem Supreme e suas relações com caracteres reprodutivos." Universidade Federal de Pelotas, 2011. http://repositorio.ufpel.edu.br/handle/ri/2590.
Full textThe aromatase enzyme complex is responsible for converting androgens into estrogens in vertebrates. One of the key enzymes of this complex is the cytochrome P450arom gene expression and regulation of this enzyme is directly linked to sexual differentiation. Estrogen is essential for the development of the gonads and various physiological processes, ranging from normal growth to reproductive behavior. This study aimed to correlate the polymorphisms in the genes CYP19a CYP19b. In a first moment with three strains used in aquaculture (Chitralada, Supreme and GIFT) using thirty animals of each strain and, a second time only with the Supreme strain which has also the objective of analyzing the sex ratios found in both treatments at different temperatures of water and to establish possible relationships between them, analyzing the 122 animals treated at 25 ° C and 129 animals of treatment at 35 ° C. After extraction of DNA samples were subjected to PCR using primers designed to flank a region of interest. After confirmation of amplification samples were subjected to electrophoresis on Origins apparatus for identification of alleles. In the first study was identified that there is a polymorphism in the promoter region of CYP19b in the three strains. Were observed three alleles, ranging from 141 to 123 bp. Thus the primers for amplification of microsatellites in the regulatory region of the gene CYP19b were efficient, and therefore its use for identification of mutations in this region can be employed in the typical analysis of microsatellites. In the second study was identified that there is a polymorphism in the regulatory region of the gene 10 CYP19a, 5 alleles were observed. The proportion of females and males found in the treatment at 25 ° C was 1:2,3 1:2,88 and treatment at 35 ° C. However, it can be assumed that the polymorphism present in this portion of the regulatory region may be related to sex reversal found. Whereas the attempt to select individuals with polymorphisms in the regulatory region of the aromatase gene (and CYP19a CYP19b) is an essential study to evaluate the expression levels of both, so you can see how it is being expressed in individuals that will reverse or not , allowing for the reversal temperature with a higher proportion.
O complexo enzimático da aromatase é responsável pela conversão de andrógenos em estrógenos nos vertebrados. Uma das principais enzimas deste complexo é o citocromo P450arom e a regulação da expressão gênica desta enzima está diretamente ligada à diferenciação sexual. O estrogênio é essencial para o desenvolvimento das gônadas e diversos processos fisiológicos, que vão desde o crescimento normal até o comportamento reprodutivo. Este estudo teve como objetivo correlacionar o polimorfismo nos genes CYP19a e CYP19b. Em um primeiro momento com três linhagens utilizadas na piscicultura brasileira (Chitralada, Supreme e GIFT) utilizando trinta animais de cada linhagem e, em um segundo momento somente com a linhagem Supreme a qual tem-se o objetivo também de analisar as proporções de sexo encontrado em dois tratamentos com temperaturas diferentes da água e estabelecer possíveis relações entre eles, analisando 122 animais do tratamento a 25°C e 129 animais do tratamento a 35°C. Após a extração de DNA as amostras foram submetidas a PCR utilizando os primers desenhados para flanquear uma região de interesse. Após confirmação da amplificação as amostras foram submetidas à separação eletroforética no aparato Origins para identificação dos alelos. No primeiro estudo foi identificado que existe um polimorfismo na região promotora de CYP19b nas três linhagens. Foram observamos três alelos, variando entre 141 e 123 pb. Assim os primers para a amplificação de microssatélite na região regulatória do gene CYP19b foram 8 eficientes e, portanto, seu uso para identificação de mutações nesta região pode ser empregada na análise típica de microssatélite. No segundo trabalho foi identificado que há um polimorfismo na região regulatória do gene CYP19a, onde foram observados 5 padrões de bandas (supostamente alelos). A proporção de fêmeas e machos encontrada no tratamento a 25°C foi de 1:2,3 e de 1:2,88 no tratamento a 35°C. Contudo, supõe-se que o polimorfismo presente nesta porção da região regulatória pode estar relacionado à reversão sexual encontrada. Considerando a tentativa de selecionar indivíduos que apresentem polimorfismo na região regulatória dos genes da aromatase (CYP19a e CYP19b), é indispensável um estudo para avaliar os níveis de expressão de ambos, para que se possa observar como está sendo expressado em indivíduos que revertem ou não, possibilitando assim a reversão por temperatura com uma proporção mais elevada.
Thaler, Kerstin [Verfasser], and Peter Andreas [Gutachter] Fasching. "Bedeutung von zwei Single Nucleotid Polymorphismen im Aromatase-Gen (CYP19A1) für die Entstehung einer Mammakarzinomerkrankung - Eine Fall-Kontroll-Studie / Kerstin Thaler ; Gutachter: Peter Andreas Fasching." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/113917858X/34.
Full textBouchard, Marie-France. "Fonctions aberrantes des facteurs de transcription GATA chez l'humain : régulation de l'expression ectopique du gène CYP19A1 par GATA3/4 dans les cellules de cancer du sein et effet des mutations ponctuelles de GATA4 sur la régulation de ses gènes cibles gonadiques." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26555/26555.pdf.
Full textBook chapters on the topic "CYP199A4"
Akhtar, Muhammad, and J. Neville Wright. "Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1." In Advances in Experimental Medicine and Biology, 107–30. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16009-2_4.
Full text"CYP19A1." In Springer Reference Medizin, 643. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_310933.
Full textConference papers on the topic "CYP199A4"
Vinnikava, V. Y., Alena Mikhalenka, Alena Kuzminova, DA V. Bajda, and A. V. Kilchevsky. "CYP19A1 and СOMT polymorphisms in elderly people and long-livers of Belarus." In XIth International Congress of Geneticists and Breeders from the Republic of Moldova. Scientific Association of Geneticists and Breeders of the Republic of Moldova, Institute of Genetics, Physiology and Plant Protection, Moldova State University, 2021. http://dx.doi.org/10.53040/cga11.2021.047.
Full textLin, Jennifer H., Shumin M. Zhang, Marc J. Gunter, JoAnn E. Manson, Kathryn M. Rexrode, Nancy R. Cook, Peter Kraft, Barbara B. Cochrane, Rowan T. Chlebowski, and Gloria Y. F. Ho. "Abstract A67: The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-a67.
Full textStarlard-Davenport, Athena, Rosalind B. Penney, Ishwori Dhakal, and Susan Kadlubar. "Abstract 547: Ethnic differences in CYP19A1 intronic SNPs and haplotype distributions among African American and Caucasian populations." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-547.
Full textMassillo, Cintia, Guillermo N. Dalton, Juliana Porretti, Georgina Scalise, Paula L. Farré, Colin Clyne, Paola De Luca, and Adriana De Siervi. "Abstract 5496: Intratumor estradiol increment mediated by CtBP1/CYP19A1 decreases the proliferation of androgen insensitive prostate tumor cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-5496.
Full textPark, I., J. Ro, K. Lee, S. Kim, and Y. Lee. "Single Nucleotide Polymorphisms of CYP19A1, rs10459592 and rs4775936 Predict Clinical Benefit of Letrozole in Patients with Metastatic Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-2117.
Full textJohansson, H., S. Gandini, V. Aristarco, D. Macis, A. Guerrieri-Gonzaga, D. Serrano, G. Pruneri, et al. "Abstract P4-08-05: Impact of common polymorphisms of CYP19A1 and UGT2B17 gene deletion on early endocrine-responsive postmenopausal breast cancer." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p4-08-05.
Full textWang, X., X. Shao, Y. Zheng, L. Shi, and Y. Huang. "Abstract P3-07-22: RS1008805 polymorphism in CYP19A1 gene is related to the efficacy of hormone therapy in early breast cancer." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p3-07-22.
Full textLo, Wing-Yee, Werner Schroth, Reiner Hoppe, Marjanka Schmidt, Montserrat Garcia-Closas, Paul Pharaoh, Per Hall, Douglas Easton, Peter Fasching, and Hiltrud Brauch. "Abstract 5483: CYP19A1 genetic variation is a potential predictor of outcome in ER-positive postmenopausal early breast cancer patients treated with tamoxifen." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5483.
Full textDabydeen, Sarah A., Weisheng Wang, Edgar S. Diaz-Cruz, Levy Kopelovich, Robert I. Glazer, and Priscilla A. Furth. "Abstract 197: Reduction in lobular but not ductal hyperplasia by the PGR inhibitor ORG33628 in a CYP19A1 overexpressing mouse model of breast cancer risk." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-197.
Full textChachibaia, Tamar, and Joy Hoskeri. "In silico computer simulation risk assessment of triazole fungicides on human cytochrome p450 aromatase enzyme: cyp19a1 inhibition by triazoles using autodock software." In MOL2NET, International Conference on Multidisciplinary Sciences. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-f002.
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