Academic literature on the topic 'CYN'

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Journal articles on the topic "CYN"

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Coats, Karen. "Alone by Cyn Balog." Bulletin of the Center for Children's Books 71, no. 4 (2017): 149. http://dx.doi.org/10.1353/bcc.2017.0832.

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Coats, Karen. "Unnatural Deeds by Cyn Balog." Bulletin of the Center for Children's Books 70, no. 4 (2016): 164. http://dx.doi.org/10.1353/bcc.2016.0945.

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Coats, Karen. "That Night by Cyn Balog." Bulletin of the Center for Children's Books 72, no. 9 (2019): 379. http://dx.doi.org/10.1353/bcc.2019.0305.

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Chichova, Mariela, Oskan Tasinov, Milena Shkodrova, Milena Mishonova, Iliyana Sazdova, Bilyana Ilieva, Dilyana Doncheva-Stoimenova, et al. "New Data on Cylindrospermopsin Toxicity." Toxins 13, no. 1 (January 8, 2021): 41. http://dx.doi.org/10.3390/toxins13010041.

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Cylindrospermopsin (CYN) is a widely spread cyanotoxin that can occur in fresh water and food. This research aims to investigate CYN toxicity by studying the effects of drinking 0.25 nM of CYN-contaminated water from a natural source, and of the direct application of moderate concentrations of CYN on different animal targets. The chosen structures and activities are rat mitochondria inner membrane permeability, mitochondrial ATP synthase (ATPase) and rat liver diamine oxidase (DAO) activities (EC 1.4.3.22.), the force of the contraction of an excised frog heart preparation with functional innervation, and the viability of a human intestinal epithelial cell line (HIEC-6). The oral exposure to CYN decreased the reverse (hydrolase) activity of rat liver ATPase whereas its short-term, in vitro application was without significant effect on this organelle, DAO activity, heart contractions, and their neuronal regulation. The application of CYN reduced HIEC-6 cells’ viability dose dependently. It was concluded that CYN is moderately toxic for the human intestinal epithelial cells, where the regeneration of the epithelial layer can be suppressed by CYN. This result suggests that CYN may provoke pathological changes in the human gastrointestinal tract.
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Chichova, Mariela, Oskan Tasinov, Milena Shkodrova, Milena Mishonova, Iliyana Sazdova, Bilyana Ilieva, Dilyana Doncheva-Stoimenova, et al. "New Data on Cylindrospermopsin Toxicity." Toxins 13, no. 1 (January 8, 2021): 41. http://dx.doi.org/10.3390/toxins13010041.

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Cylindrospermopsin (CYN) is a widely spread cyanotoxin that can occur in fresh water and food. This research aims to investigate CYN toxicity by studying the effects of drinking 0.25 nM of CYN-contaminated water from a natural source, and of the direct application of moderate concentrations of CYN on different animal targets. The chosen structures and activities are rat mitochondria inner membrane permeability, mitochondrial ATP synthase (ATPase) and rat liver diamine oxidase (DAO) activities (EC 1.4.3.22.), the force of the contraction of an excised frog heart preparation with functional innervation, and the viability of a human intestinal epithelial cell line (HIEC-6). The oral exposure to CYN decreased the reverse (hydrolase) activity of rat liver ATPase whereas its short-term, in vitro application was without significant effect on this organelle, DAO activity, heart contractions, and their neuronal regulation. The application of CYN reduced HIEC-6 cells’ viability dose dependently. It was concluded that CYN is moderately toxic for the human intestinal epithelial cells, where the regeneration of the epithelial layer can be suppressed by CYN. This result suggests that CYN may provoke pathological changes in the human gastrointestinal tract.
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Díez-Quijada, Leticia, Klara Hercog, Martina Štampar, Metka Filipič, Ana M. Cameán, Ángeles Jos, and Bojana Žegura. "Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line." Toxins 12, no. 12 (December 8, 2020): 778. http://dx.doi.org/10.3390/toxins12120778.

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Simultaneous occurrence of cylindrospermopsin (CYN) and microcystin-LR (MCLR) has been reported in the aquatic environment and thus human exposure to such mixtures is possible. As data on the combined effects of CYN/MCLR are scarce, we aimed to investigate the adverse effects related to genotoxic activities induced by CYN (0.125, 0.25 and 0.5 µg/mL) and MCLR (1 µg/mL) as single compounds and their combinations in HepG2 cells after 24 and 72 h exposure. CYN and CYN/MCLR induced DNA double-strand breaks after 72 h exposure, while cell cycle analysis revealed that CYN and CYN/MCLR arrested HepG2 cells in G0/G1 phase. Moreover, CYN and the combination with MCLR upregulated CYP1A1 and target genes involved in DNA-damage response (CDKN1A, GADD45A). Altogether, the results showed that after 72 h exposure genotoxic activity of CYN/MCLR mixture was comparable to the one of pure CYN. On the contrary, MCLR (1 µg/mL) had no effect on the viability of cells and had no influence on cell division. It did not induce DNA damage and did not deregulate studied genes after prolonged exposure. The outcomes of the study confirm the importance of investigating the combined effects of several toxins as the effects can differ from those induced by single compounds.
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Llana-Ruiz-Cabello, Maria, Angeles Jos, Ana Cameán, Flavio Oliveira, Aldo Barreiro, Joana Machado, Joana Azevedo, et al. "Analysis of the Use of Cylindrospermopsin and/or Microcystin-Contaminated Water in the Growth, Mineral Content, and Contamination of Spinacia oleracea and Lactuca sativa." Toxins 11, no. 11 (October 28, 2019): 624. http://dx.doi.org/10.3390/toxins11110624.

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Cyanobacteria and cyanotoxins constitute a serious environmental and human health problem. Moreover, concerns are raised with the use of contaminated water in agriculture and vegetable production as this can lead to food contamination and human exposure to toxins as well as impairment in crop development and productivity. The objective of this work was to assess the susceptibility of two green vegetables, spinach and lettuce, to the cyanotoxins microcystin (MC) and cylindrospermopsin (CYN), individually and in mixture. The study consisted of growing both vegetables in hydroponics, under controlled conditions, for 21 days in nutrient medium doped with MC or CYN at 10 μg/L and 50 μg/L, or CYN/MC mixture at 5 + 5 μg/L and 25 + 25 μg/L. Extracts from M. aeruginosa and C. ovalisporum were used as sources of toxins. The study revealed growth inhibition of the aerial part (Leaves) in both species when treated with 50µg/L of MC, CYN and CYN/MC mixture. MC showed to be more harmful to plant growth than CYN. Moreover spinach leaves growth was inhibited by both 5 + 5 and 25 + 25 µg/L CYN/MC mixtures, whereas lettuce leaves growth was inhibited only by 25 + 25 µg/L CYN/MC mixture. Overall, growth data evidence increased sensitivity of spinach to cyanotoxins in comparison to lettuce. On the other hand, plants exposed to CYN/MC mixture showed differential accumulation of CYN and MC. In addition, CYN, but not MC, was translocated from the roots to the leaves. CYN and MC affected the levels of minerals particularly in plant roots. The elements most affected were Ca, K and Mg. However, in leaves K was the mineral that was affected by exposure to cyanotoxins.
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Flores-Rojas, Esterhuizen-Londt, and Pflugmacher. "Uptake, Growth, and Pigment Changes in Lemna minor L. Exposed to Environmental Concentrations of Cylindrospermopsin." Toxins 11, no. 11 (November 7, 2019): 650. http://dx.doi.org/10.3390/toxins11110650.

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Cylindrospermopsin (CYN)-producing cyanobacterial blooms such as Raphidiopsis, Aphanizomenon, Anabaena, Umezakia, and Lyngbya spp. are occurring more commonly and frequently worldwide. CYN is an environmentally stable extracellular toxin, which inhibits protein synthesis, and, therefore, can potentially affect a wide variety of aquatic biota. Submerged and floating macrophytes, as primary producers in oligotrophic habitats, are at risk of exposure and information on the effects of CYN exposure at environmentally relevant concentrations is limited. In the present study, we investigated CYN uptake in the floating macrophyte Lemna minor with exposure to reported environmental concentrations. The effects were evaluated in terms of bioaccumulation, relative plant growth, and number of fronds per day. Variations in the concentrations and ratios of the chlorophylls as stress markers and carotenoids as markers of oxidative stress defense were measured. With exposure to 25 μg/L, L. minor could remove 43% of CYN within 24 h but CYN was not bioaccumulated. Generally, the pigment concentrations were elevated with exposure to 0.025, 0.25, and 2.5 μg/L CYN after 24 h, but normalized quickly thereafter. Changes in relative plant growth were observed with exposure to 0.25 and 2.5 μg/L CYN. Adverse effects were seen with these environmentally realistic concentrations within 24 h; however, L. minor successfully recovered within the next 48–96 h.
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Pierangelini, Mattia, Rati Sinha, Anusuya Willis, Michele A. Burford, Philip T. Orr, John Beardall, and Brett A. Neilan. "Constitutive Cylindrospermopsin Pool Size in Cylindrospermopsis raciborskii under Different Light and CO2Partial Pressure Conditions." Applied and Environmental Microbiology 81, no. 9 (February 27, 2015): 3069–76. http://dx.doi.org/10.1128/aem.03556-14.

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ABSTRACTCylindrospermopsin (CYN) and 7-deoxy-cylindrospermopsin (dCYN) are potent hepatotoxic alkaloids produced by numerous species of cyanobacteria, including the freshwaterCylindrospermopsis raciborskii.C. raciborskiiis an invasive cyanobacterium, and the study of how environmental parameters drive CYN production has received significant interest from water managers and health authorities. Light and CO2affect cell growth and physiology in photoautotrophs, and these are potential regulators of cyanotoxin biosynthesis. In this study, we investigated how light and CO2affect CYN and dCYN pool size as well as the expression of the key genes,cyrAandcyrK, involved in CYN biosynthesis in a toxicC. raciborskiistrain. For cells growing at different light intensities (10 and 100 μmol photons m−2s−1), we observed that the rate of CYN pool size production (μCYN) was coupled to the cell division rate (μc) during batch culture. This indicated that CYN pool size under our experimental conditions is constant and cell quotas of CYN (QCYN) and dCYN (QdCYN) are fixed. Moreover, a lack of correlation between expression ofcyrAand total CYN cell quotas (QCYNs) suggests that the CYN biosynthesis is regulated posttranscriptionally. Under elevated CO2(1,300 ppm), we observed minor effects on QCYNand no effects on expression ofcyrAandcyrK. We conclude that the CYN pool size is constitutive and not affected by light and CO2conditions. Thus,C. raciborskiibloom toxicity is determined by the absolute abundance ofC. raciborskiicells within the water column and the relative abundance of toxic and nontoxic strains.
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Flores-Rojas, Nelida Cecilia, and Maranda Esterhuizen. "Uptake and Effects of Cylindrospermopsin: Biochemical, Physiological and Biometric Responses in The Submerged Macrophyte Egeria densa Planch." Water 12, no. 11 (October 26, 2020): 2997. http://dx.doi.org/10.3390/w12112997.

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Cylindrospermopsin (CYN) is being detected in surface waters more commonly and frequently worldwide. This stable, extracellular cyanotoxin causes protein synthesis inhibition, thus posing a risk to aquatic biota, including macrophytes, which serve as primary producers. Nevertheless, data regarding the effects caused by environmental concentrations of CYN is still limited. In the presented study, the uptake of CYN at environmental concentrations by the submerged macrophyte Egeria densa was investigated. Bioaccumulation, changes in the plant biomass, as well as shoot-length were assessed as responses. Variations in the cellular H2O2 levels, antioxidative enzyme activities, as well as concentrations and ratios of the photosynthetic pigments were also measured. E. densa removed 54% of CYN within 24 h and up to 68% after 336 h; however, CYN was not bioaccumulated. The antioxidative enzyme system was activated by CYN exposure. Pigment concentrations decreased with exposure but normalized after 168 h. The chlorophyll a to b ratio increased but normalized quickly thereafter. Carotenoids and the ratio of carotenoids to total chlorophylls increased after 96 h suggesting participation in the antioxidative system. Growth stimulation was observed. The ability to remove CYN and resistance to CYN toxicity within 14 days proved E. densa as suitable for phytoremediation; nonetheless, prolonged exposure (32 days) resulted in adverse effects related to CYN uptake, which needs to be studied further.
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Dissertations / Theses on the topic "CYN"

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Bain, Peter A., and n/a. "Gene Expression Profiling of Cylindrospermopsin Toxicity." Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20080404.145834.

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Cylindrospermopsin (CYN) is a toxic alkaloid produced by several freshwater cyanobacterial species, the most prevalent in Australian waters being Cylindrospermopsis raciborskii. The occurrence of CYN-producing cyanobacteria in drinking water sources worldwide poses a potential human health risk, with one well-documented case of human poisoning attributed to the toxin. While extensive characterisation of CYN-induced toxicity has been conducted in rodents both in vivo and in primary cell cultures, little is known about mechanisms of toxicity in human cell types. This thesis describes studies undertaken to further define the molecular mechanisms of CYN toxicity in human cells. Concentration-response relationships were determined in various cultured human cell types using standard toxicity assays. As expected, CYN caused dose-dependent decreases in the growth of three cell lines, HepG2, Caco-2 and HeLa, and one primary cell type, human dermal fibroblasts, according to tetrazolium reduction assays. CYN treatment did not disrupt cellular membranes according to the lactate dehydrogenase release assay in HepG2 or Caco-2 cells after 24, 48 or 72 h exposure, but did cause membrane disruption in fibroblasts after 72 h exposure to relatively high concentrations of the toxin. Apoptosis occurred more readily in HeLa cells than HepG2 cells or fibroblasts, with 72 h exposure to 1 &mug/mL required before statistically significant rates of apoptosis occurred in the latter cell types. CYN did not appear to directly affect the structure of actin filaments or microtubules under the conditions used in the present study. The major portion of the work presented in this thesis comprises a large-scale interrogation of changes in gene expression induced by the toxin in cultured cells. To assess the effects of CYN on global gene expression, relative messenger RNA (mRNA) levels in human dermal fibroblasts and HepG2 cells after 6 h and 24 h exposure to 1 &mug/mL CYN were determined using oligonucleotide microarrays representing approximately 19 000 genes. Overall, the number of transcripts significantly altered in abundance was greater in fibroblasts than in HepG2 cells. In both cell types, mRNA levels for genes related to amino acid biosynthesis, carbohydrate metabolism, and protein folding and transport were reduced after CYN treatment, while transcripts representing genes for apoptosis, RNA biosynthesis and RNA processing increased in abundance. More detailed data analyses revealed the modulation of a number of stress response pathways—genes regulated by NF-&kappaB were induced, DNA damage response pathways were up-regulated, and a large number of genes involved in endoplasmic reticulum stress were strongly down-regulated. Genes for the synthesis and processing of mRNA, tRNA and rRNA were strongly up-regulated, indicating that CYN treatment may increase the turnover of all forms of cellular RNA. A small group of genes were differentially expressed in HepG2 cells and fibroblasts, revealing cell-specific responses to the toxin. Selected changes in transcript level were validated using real-time quantitative reverse transcriptase PCR (qRT-PCR). The modulation of stress response pathways by CYN, indicated by microarray analysis, was further investigated using other methods. The role of tumour suppressor protein p53 in CYN-mediated gene expression was confirmed by measuring the expression of known p53-regulated genes following CYN treatment of HepG2 cells and human dermal fibroblasts using qRT-PCR. Western blotting of protein extracts from CYNtreated cells showed that p53 protein accumulation occurred in HepG2 cells, providing additional evidence of the activation of the p53 pathway by CYN in this cell line. The immediate-early genes JUN and FOS were found to be induced by CYN in a concentration-dependent manner, and MYC was induced to a lesser extent. The mitogen-activated protein kinase c-Jun NH2-terminal kinase, implicated in the ribotoxic stress response initiated by damage to ribosomal RNA, appeared to become phosphorylated in HeLa cells after CYN exposure, suggesting that ribotoxic stress may occur in response to CYN in at least some cell types. The expression of a reporter gene under the control of a response element specific for NF-&kappaB was induced at the mRNA level but inhibited at the protein level. This shows that while transcription factors such as p53 and NF-&kappaB are apparently activated in response to the toxin, transactivation of target genes may not necessarily manifest a corresponding increase at the protein level. The current work contributes significantly to the current understanding of cylindrospermopsin toxicity in human-derived cell types, and provides further insight into putative modes of action.
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Bain, Peter A. "Gene Expression Profiling of Cylindrospermopsin Toxicity." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367068.

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Cylindrospermopsin (CYN) is a toxic alkaloid produced by several freshwater cyanobacterial species, the most prevalent in Australian waters being Cylindrospermopsis raciborskii. The occurrence of CYN-producing cyanobacteria in drinking water sources worldwide poses a potential human health risk, with one well-documented case of human poisoning attributed to the toxin. While extensive characterisation of CYN-induced toxicity has been conducted in rodents both in vivo and in primary cell cultures, little is known about mechanisms of toxicity in human cell types. This thesis describes studies undertaken to further define the molecular mechanisms of CYN toxicity in human cells. Concentration-response relationships were determined in various cultured human cell types using standard toxicity assays. As expected, CYN caused dose-dependent decreases in the growth of three cell lines, HepG2, Caco-2 and HeLa, and one primary cell type, human dermal fibroblasts, according to tetrazolium reduction assays. CYN treatment did not disrupt cellular membranes according to the lactate dehydrogenase release assay in HepG2 or Caco-2 cells after 24, 48 or 72 h exposure, but did cause membrane disruption in fibroblasts after 72 h exposure to relatively high concentrations of the toxin. Apoptosis occurred more readily in HeLa cells than HepG2 cells or fibroblasts, with 72 h exposure to 1 µg/mL required before statistically significant rates of apoptosis occurred in the latter cell types. CYN did not appear to directly affect the structure of actin filaments or microtubules under the conditions used in the present study. The major portion of the work presented in this thesis comprises a large-scale interrogation of changes in gene expression induced by the toxin in cultured cells. To assess the effects of CYN on global gene expression, relative messenger RNA (mRNA) levels in human dermal fibroblasts and HepG2 cells after 6 h and 24 h exposure to 1 µg/mL CYN were determined using oligonucleotide microarrays representing approximately 19 000 genes. Overall, the number of transcripts significantly altered in abundance was greater in fibroblasts than in HepG2 cells. In both cell types, mRNA levels for genes related to amino acid biosynthesis, carbohydrate metabolism, and protein folding and transport were reduced after CYN treatment, while transcripts representing genes for apoptosis, RNA biosynthesis and RNA processing increased in abundance. More detailed data analyses revealed the modulation of a number of stress response pathways—genes regulated by NF-?B were induced, DNA damage response pathways were up-regulated, and a large number of genes involved in endoplasmic reticulum stress were strongly down-regulated. Genes for the synthesis and processing of mRNA, tRNA and rRNA were strongly up-regulated, indicating that CYN treatment may increase the turnover of all forms of cellular RNA. A small group of genes were differentially expressed in HepG2 cells and fibroblasts, revealing cell-specific responses to the toxin. Selected changes in transcript level were validated using real-time quantitative reverse transcriptase PCR (qRT-PCR). The modulation of stress response pathways by CYN, indicated by microarray analysis, was further investigated using other methods. The role of tumour suppressor protein p53 in CYN-mediated gene expression was confirmed by measuring the expression of known p53-regulated genes following CYN treatment of HepG2 cells and human dermal fibroblasts using qRT-PCR. Western blotting of protein extracts from CYNtreated cells showed that p53 protein accumulation occurred in HepG2 cells, providing additional evidence of the activation of the p53 pathway by CYN in this cell line. The immediate-early genes JUN and FOS were found to be induced by CYN in a concentration-dependent manner, and MYC was induced to a lesser extent. The mitogen-activated protein kinase c-Jun NH2-terminal kinase, implicated in the ribotoxic stress response initiated by damage to ribosomal RNA, appeared to become phosphorylated in HeLa cells after CYN exposure, suggesting that ribotoxic stress may occur in response to CYN in at least some cell types. The expression of a reporter gene under the control of a response element specific for NF-?B was induced at the mRNA level but inhibited at the protein level. This shows that while transcription factors such as p53 and NF-?B are apparently activated in response to the toxin, transactivation of target genes may not necessarily manifest a corresponding increase at the protein level. The current work contributes significantly to the current understanding of cylindrospermopsin toxicity in human-derived cell types, and provides further insight into putative modes of action.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Faculty of Science, Environment, Engineering and Technology
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Presutti, Pasquale. "Algoritmo per la generazione di mappe depth da immagini stereo con CNN." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.

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Lo svolgimento del lavoro è stato condotto dapprima approfondendo le tematiche legate al problema della corrispondenza stereo e, dopo un analisi generale delle reti neurali convoluzionali e delle metodologie già presenti per risolvere il matching stereo attraverso il deep learning, è stata implementata l'architettura CNN in grado di restituire una mappa di disparità sfruttando le teorie legate al mondo della computer vision.
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0gweno, Aloice 0. "Synthesis, characterization and catalytic application of carbonyl complexes of molybdenum and tungsten in epoxidation of some alkenes." University of the Western Cape, 2010. http://hdl.handle.net/11394/8214.

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>Magister Scientiae - MSc
In this thesis we describe the synthesis of several carbonyl complexes of molybdenum and tungsten, compounds (Cl-ClO). The compounds Cl- C4 are zero valent carbonyl complexes containing N-base ligands prepared by following a common synthetic procedure. Compounds Cl and C2 were metal pentacarbonyl of 3-(1-methylpyrrolidin-2-yl) pyridine while C3 and C4 are metal tetracarbonyl complexes of 3, 5- dimethylpyrazole, (M=Mo, W). The compounds C5-C10 are divalent metal carbonyl complexes. Compounds CS and C6 were 3,5-dimethylpyrazole dibromotricarbonyl metal complexes prepared from the dibromotetracarbonyl metal dimers at room temperature while the compounds C7 and C8 were cyclopentadienyl halogenoaryltricarbonyl complexes prepared from the cyclopentadienyl metal dimers. Compounds C9 and ClO were prepared from cyclopentadienyl metal dimers by reacting the [CpM(C0)3r anion with CCl4 to obtain [CpM(C0)3Cl] and further reacted with 3-(1- methylpyrrolidin-2-yl) pyridine. All the compounds, Cl-ClO, were characterized by the standard analytical techniques such as FTIR, 1H, 13C NMR; and UV-Vis spectroscopy. Compound C4 was characterized by X-ray crystallography. The structure is depicted as having a distorted octahedral geometry around the metal centre. The compounds Cl-ClO were then tested towards the epoxidation of selected cyclic and straight chain alkenes. The substrates used were cis-cyclooctene (Cyg), 1-octene (C8) cyclohexene (Cy6), 1-hexene (C6) and styrene (Sty). The epoxidation reactions were carried out at a temperature of 55 °C using tertbutylhydroperoxide (TBHP) as the oxidant and dichloroethane (DCE) as the solvent. The metal carbonyl complexes were pre-activated by first reacting them with the oxidant TBHP to obtain the metal-oxo complexes which are the active compounds for epoxidation reactions. The products were analyzed using GC techniques. The compounds, Cl-ClO showed a promising activity towards epoxidation reactions owing to the high conversions obtained by these compounds. For example, conversions of 81% (1-octene), 90% (cis-cyclooctene) were obtained by compound C5, 87% (cis-cyclooctene-compound C3, 95% (cis-cyclooctene-compound · C7) and 69% (ciscyclooctene- compound C4) for an average period of 24 h. The divalent metal carbonyl complexes showed a higher activity but with poor selectivity towards the expected epoxides compared to the zero valent metal carbonyl complexes.
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Fang, Yue. "Interfacial studies of high temperature superconducting Bi₂Sr₂Can-₁Cun 0₂n+₄ and Ag." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/17890.

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Biffi, Marcelo. "Desenvolvimento do processo de retificação com alta velocidade em sede de válvulas de motores à combustão interna usando rebolo de CBN vitrificado." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18135/tde-12022016-144728/.

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Este trabalho tem por objetivo desenvolver o processo de retificação a alta velocidade de superligas utilizando rebolos de CBN vitrificados. Para tanto, foram estudadas diversas condições de dressagem, ou seja, as influências dos parâmetros de dressagem no desempenho do rebolo CBN de liga vitrificada. A partir da escolha desses parâmetros, foi também determinado o desgaste do rebolo em diversas condições de velocidade de avanço, e a qualidade superficial das peças retificadas. Foi utilizado um sistema de mapeamento topográfico do rebolo, baseado na emissão acústica emanada da interação entre rebolo-peça, para o monitoramento do processo. Como resultado foi determinada a influência da velocidade de dressagem e da relação de velocidades na rugosidade da peça retificada. Ficou determinado também, o desgaste do rebolo de CBN em função do volume de material retificado para os diferentes materiais das superligas testadas. Através do sistema de mapeamento topográfico, determinou-se os padrões gráficos do comportamento do rebolo de CBN vitrificado. Sendo assim, verificou-se que o sucesso da aplicação de rebolos CBN vitrificados na retificação de superligas depende da qualidade superficial do rebolo após a dressagem e da escolha certa dos parâmetros de retificação, os quais dependem da constituição das ligas testadas.
The aim of this work is to develop a high speed grinding process for super alloys using vitrified CBN wheels. For that, dressing conditions were studied in order to determine its influence on the CBN wheel performance. From the chosen parameters, the wheel wear and the ground surface quality were measured for different infeed speeds. A topographical mapping system based on acoustic emission was used to monitor the grinding process. As a result, the best dressing speed and speed ratio which generated the smallest surface roughness values could be found. The CBN wheel wear was measured and its ratio to the ground volume was evaluated. Through the mapping system, some visual patterns were obtained defining the grinding wheel behavior when dressing and grinding. Thus, the success vitrified CBN wheel application for super alloys depends basically on the wheel topography after dressing and the grinding parameters, which are dose related to the work material composition.
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Jafari, haddadian Esmael. "Brownian dynamics study of cytochrome f / Rieske interactions with cytochrome c6 and plastocyanin." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1123695434.

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MOREIRA, André Luis Cavalcanti. "An adaptable storage slicing algorithm for content delivery networks." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17331.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-07-12T12:20:38Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Thesis - André Luis Cavalcanti Moreira.pdf: 3666881 bytes, checksum: 956e0e6be2bd9f076c0d30eea9d3ea25 (MD5)
Made available in DSpace on 2016-07-12T12:20:38Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Thesis - André Luis Cavalcanti Moreira.pdf: 3666881 bytes, checksum: 956e0e6be2bd9f076c0d30eea9d3ea25 (MD5) Previous issue date: 2015-08-28
Several works study the performance of Content Delivery Networks (CDNs) under various network infrastructure and demand conditions. Many strategies have been proposed to deal with aspects inherent to the CDN distribution model. Though mostly very effective, a traditional CDN approach of statically positioned elements often fails to meet quality of experience (QoE) requirements when network conditions suddenly change. CDN adaptation is a key feature in this process and some studies go even further and try to also deal with demand elasticity by providing an elastic infrastructure (cloud computing) to such CDNs. Each Content Provider (CP) gets served only the amount of storage space and network throughput that it needs and pays only for what has been used. Some IaaS providers offer simple CDN services on top of their infrastructure. However, in general, there is a lack of PaaS tools to create rapidly a CDN. There is no standard or open source software able to deliver CDN as a service for each tenant through well-known managers. A PaaS CDN should be able to implement content delivery service in a cloud environment, provision and orchestrate each tenant, monitor usage and make decisions on planning and dimensioning of resources. This work introduces a framework for the allocation of resources of a CDN in a multi-tenant environment. The framework is able to provision and orchestrate multi-tenant virtual CDNs and can be seen as a step towards a PaaS CDN. A simple dot product based module for network change detection is presented and a more elaborate multi-tenant resource manager model is defined. We solve the resulting ILP problem using both branch and bound as well as an efficient cache slicing algorithm that employs a three phase heuristic for orchestration of multi-tenant virtual CDNs. We finally show that a distributed algorithm with limited local information may be also offer reasonable resource allocation while using limited coordination among the different nodes. A self-organization behavior emerges when some of the nodes reach consensus.
Vários trabalhos estudam o desempenho de Redes de Distribuição de Conteúdo (CDN) em diferentes condições e demanda e de infraestrutura. Muitas estratégias têm sido propostas para lidar com aspectos inerentes ao modelo de distribuição de CDN. Embora essas técnicas sejam bastante eficazes, uma abordagem tradicional de elementos estaticamente posicionados numa CDN muitas vezes não consegue atender os requisitos de qualidade de experiência (QoE) quando as condições da rede mudam repentinamente. Adaptação CDN é uma característica fundamental neste processo e alguns estudos vão ainda mais longe e tentam lidar com a elasticidade da demanda, proporcionando uma infraestrutura elástica (computação em nuvem) para a CDN. Cada provedor de conteúdo obtém apenas a quantidade de armazenamento e de rede necessários, pagando apenas pelo efetivo uso. Alguns provedores IaaS oferecem serviços de CDN sobre suas estruturas. No entanto, em geral, não existe padrão ou softwares de código aberto capazes de entregar serviços de CDN por meio de gerenciadores. Uma CDN PaaS deve ser capaz de fornecer um serviço de entrega de conteúdo em um ambiente de nuvem, provisionar e orquestrar cada tenant, monitorar uso e tomar decisões de planejamento e dimensionamento de recursos. Este trabalho apresenta um framework para alocação de recursos de uma CDN em ambiente multi-tenant. O framework é capaz de provisionar e orquestrar CDNs virtuais e pode ser visto como um passo em direção a uma PaaS CDN. Um módulo baseado em simples produto escalar para detecção de mudanças na rede é apresentado, bem como um modelo mais elaborado de gerenciamento de recursos. Resolvemos o problema ILP resultante dessa abordagem por meio de um algoritmo de divisão de cache que emprega uma heurística em três fases para a orquestração de CDN virtuais. Por fim, mostramos uma outra abordagem com algoritmo distribuído que usa informação local e que também oferece uma alocação razoável usando coordenação limitada entre os diferentes nós. Um comportamento de auto-organização surge quando alguns desses nós chegam a um consenso.
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Lu, Xiaojing. "SIMULTANEOUS CONFIDENCE BOUNDS WITH APPLICATIONS TO DRUG STABILITY STUDIES." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1145885659.

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Liu, Xiaoxia. "Semi-Empirical Likelihood Confidence Intervals for the ROC Curve with Missing Data." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/math_theses/89.

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Abstract:
The receiver operating characteristic (ROC) curve is one of the most commonly used methods to compare the diagnostic performances of two or more laboratory or diagnostic tests. In this thesis, we propose semi-empirical likelihood based confidence intervals for ROC curves of two populations, where one population is parametric while the other one is non-parametric and both populations have missing data. After imputing missing values, we derive the semi-empirical likelihood ratio statistic and the corresponding likelihood equations. It has been shown that the log-semi-empirical likelihood ratio statistic is asymptotically chi-square distributed. The estimating equations are solved simultaneously to obtain the estimated lower and upper bounds of semi-empirical likelihood confidence intervals. Simulation studies are conducted to evaluate the finite sample performance of the proposed empirical likelihood confidence intervals with various sample sizes and different missing rates.
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Books on the topic "CYN"

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Original Cyn. New York: Delta Trade Paperbacks, 2005.

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Elis, Meg. Cyn daw'r gaeaf. Llandysul: Gwasg Gomer, 1985.

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Fawcett, Nick. Cyn ei ddod ? Bangor: Cyhoeddiadau'r Gair, 2004.

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Elis, Islwyn Ffowc. Cyn oeri'r gwaed. Llandysul: Gwasg Gomer, 1988.

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Elis, Meg. Cyn daw'r gaeaf. Llandysul, Dyfed: Gomer, 1985.

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Elis, Islwyn Ffowc. Cyn oeri'r gwaed. 9th ed. Llandysul: Gomer, 1996.

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Pol, Lluís Ferran de. Cyn y Wawr. Llandysul: Gomer, 1994.

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Stori cyn cysgu. Llanrwst: Gwasg Carreg Gwalch, 2008.

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Cathy, Baxter, and Wyn Delyth, eds. Cyn gwneud y sêr. Bangor: Cyhoeddiadau'r Gair, 1998.

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Parry, Bill. Cyn y cardotyn dall. Caernarfon: Gwasg Gwynedd, 1990.

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Book chapters on the topic "CYN"

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Chríost, Diarmait Mac Giolla. "Meg Elis I’r Gad (1975), Carchar (1978) and Cyn Daw’r Gaeaf (1985)." In Welsh Writing, Political Action and Incarceration, 105–26. London: Palgrave Macmillan UK, 2013. http://dx.doi.org/10.1057/9781137372277_6.

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Moro, Simonetta. "Conclusion." In Mapping Paradigms in Modern and Contemporary Art, 172–79. New York: Routledge, 2021. http://dx.doi.org/10.4324/9780367196400-con.

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Campesi, Giuseppe. "Conclusions." In Policing Mobility Regimes, 299–303. London: Routledge, 2021. http://dx.doi.org/10.4324/9780429291548-con.

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Potts, John, and Nigel Helyer. "Conclusion." In Science Meets Art, 161–62. New York: Jenny Stanford Publishing, 2022. http://dx.doi.org/10.1201/9781003294429-con.

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Zonana, Joyce. "“Tee,” “Cyn-Cyn,” “Cynthia,” “Dou-Dou”:." In MIDDLE PASSAGES AND THE HEALING PLACE OF HISTORY, 139–54. Ohio State University Press, 2021. http://dx.doi.org/10.2307/j.ctv1cvvb9s.12.

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"2.9.10 Stories of famous horses. Cyn. 1.198-269." In Stories from the Mountains, Stories from the Sea, 104–15. Göttingen: Vandenhoeck & Ruprecht, 2003. http://dx.doi.org/10.13109/9783666252495.104.

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"2.9.14 Story of Dionysus and Pentheus, Cyn. 4.233-319." In Stories from the Mountains, Stories from the Sea, 129–49. Göttingen: Vandenhoeck & Ruprecht, 2003. http://dx.doi.org/10.13109/9783666252495.129.

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"2.9.11 Eugenics in horses, doves and men, Cyn. 1.326-367." In Stories from the Mountains, Stories from the Sea, 115–21. Göttingen: Vandenhoeck & Ruprecht, 2003. http://dx.doi.org/10.13109/9783666252495.115.

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"2.9.12 Mating instinct is strongest in spring, Cyn. 1.376-392." In Stories from the Mountains, Stories from the Sea, 121–25. Göttingen: Vandenhoeck & Ruprecht, 2003. http://dx.doi.org/10.13109/9783666252495.121.

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Lass, Roger. "Cyn(e)wulf Revisited: The Problem of the Runic Signatures." In An Historic Tongue, 17–30. Routledge, 2020. http://dx.doi.org/10.4324/9781003074687-3.

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Conference papers on the topic "CYN"

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Chen, H. M., W. H. Huang, M. L. Kuo, and C. Y. Kuo. "A New Compound, Cyn-1324, for Treating with Asthma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2908.

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Kamiyama, Noriaki. "CCN economics: Can ISPs profit by introducing CCN?" In 2014 10th International Conference on Network and Service Management (CNSM). IEEE, 2014. http://dx.doi.org/10.1109/cnsm.2014.7014166.

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Herruzo, P., M. Bolaños, and P. Radeva. "Can a CNN recognize Catalan diet?" In APPLICATION OF MATHEMATICS IN TECHNICAL AND NATURAL SCIENCES: 8th International Conference for Promoting the Application of Mathematics in Technical and Natural Sciences - AMiTaNS’16. Author(s), 2016. http://dx.doi.org/10.1063/1.4964956.

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Ma, Ge, and Zhen Chen. "Comparative study on CCN and CDN." In IEEE INFOCOM 2014 - IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS). IEEE, 2014. http://dx.doi.org/10.1109/infcomw.2014.6849209.

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Jafri, Syed M. A. H., Ahmed Hemani, and Dimmitrios Stathis. "Can a reconfigurable architecture beat ASIC as a CNN accelerator?" In 2017 International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation (SAMOS). IEEE, 2017. http://dx.doi.org/10.1109/samos.2017.8344616.

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Sarjant, Samuel, Catherine Legg, Michael Robinson, and Olena Medelyan. ""All You Can Eat" Ontology-Building: Feeding Wikipedia to Cyc." In 2009 IEEE/WIC/ACM International Joint Conference on Web Intelligence and Intelligent Agent Technology. IEEE, 2009. http://dx.doi.org/10.1109/wi-iat.2009.60.

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Ekiz, Ahmet, Kaplan Kaplan, and H. Metin Ertunc. "Classification of White Blood Cells Using CNN and Con-SVM." In 2021 29th Signal Processing and Communications Applications Conference (SIU). IEEE, 2021. http://dx.doi.org/10.1109/siu53274.2021.9477962.

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Wang, Chien-Yao, Hong-Yuan Mark Liao, Yueh-Hua Wu, Ping-Yang Chen, Jun-Wei Hsieh, and I.-Hau Yeh. "CSPNet: A New Backbone that can Enhance Learning Capability of CNN." In 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW). IEEE, 2020. http://dx.doi.org/10.1109/cvprw50498.2020.00203.

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Hirakawa, Yasunori, and Yoji Kuroda. "Handcrafted Features Can Help End-to-End Pose Estimation Using CNN." In 2022 IEEE/SICE International Symposium on System Integration (SII). IEEE, 2022. http://dx.doi.org/10.1109/sii52469.2022.9708741.

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Hua, Shizhen. "Can CNY Internationalization Eliminate Overcapacity ofSteel? ——Research Based on Data Mining." In 2022 International Conference on Computer Science, Information Engineering and Digital Economy (CSIEDE 2022). Paris, France: Atlantis Press, 2022. http://dx.doi.org/10.2991/978-94-6463-108-1_88.

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Reports on the topic "CYN"

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Hudson, James G. CCN Spectral Measurements. Office of Scientific and Technical Information (OSTI), February 2009. http://dx.doi.org/10.2172/948468.

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Lefkowitz, Larry, Jon Curtis, and Michael Witbrock. Accessible Research Cyc. Fort Belvoir, VA: Defense Technical Information Center, September 2007. http://dx.doi.org/10.21236/ada473356.

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Meyer, Chris. CVN 78 Gerald R. Ford Class Nuclear Aircraft Carrier (CVN 78). Fort Belvoir, VA: Defense Technical Information Center, December 2013. http://dx.doi.org/10.21236/ada613351.

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Meyer, Chris. CVN 78 Gerald R. Ford Class Nuclear Aircraft Carrier (CVN 78). Fort Belvoir, VA: Defense Technical Information Center, November 2015. http://dx.doi.org/10.21236/ad1019138.

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Zuluaga-Rivera, Octavio Antonio. Comercio exterior antioqueño con Estados Unidos : reflexiones con ocasión del TLC. Bogotá, Colombia: Banco de la República, November 2005. http://dx.doi.org/10.32468/eser.34.

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Neal, Jeanette, Benjamin Rode, Chris Crowner, Dave Gunning, and John Gucwa. Leveraging Cyc for IAA. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada401087.

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Fernández-Villaverde, Jesús, and Daniel Sanches. Can Currency Competition Work? Cambridge, MA: National Bureau of Economic Research, April 2016. http://dx.doi.org/10.3386/w22157.

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Bauer, Michal, Christopher Blattman, Julie Chytilová, Joseph Henrich, Edward Miguel, and Tamar Mitts. Can War Foster Cooperation? Cambridge, MA: National Bureau of Economic Research, June 2016. http://dx.doi.org/10.3386/w22312.

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Clarke, Kester Diederik. Formed HIP Can Processing. Office of Scientific and Technical Information (OSTI), July 2015. http://dx.doi.org/10.2172/1210211.

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Hintz, Willis L. Can NATO Survive Perestroika? Fort Belvoir, VA: Defense Technical Information Center, May 1989. http://dx.doi.org/10.21236/ada212508.

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