Academic literature on the topic 'Cylindrospermopsin toxicity'
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Journal articles on the topic "Cylindrospermopsin toxicity"
González-Blanco, Carlos, Felipe Augusto Dörr, Renata Albuquerque, Janice Onuki, and Ernani Pinto. "Alternative Isolation Protocol for Desulfo and Zwitterionic Cylindrospermopsin Alkaloids and Comparison of Their Toxicity in HepG2 Cells." Molecules 25, no. 13 (July 2, 2020): 3027. http://dx.doi.org/10.3390/molecules25133027.
Full textChichova, Mariela, Oskan Tasinov, Milena Shkodrova, Milena Mishonova, Iliyana Sazdova, Bilyana Ilieva, Dilyana Doncheva-Stoimenova, et al. "New Data on Cylindrospermopsin Toxicity." Toxins 13, no. 1 (January 8, 2021): 41. http://dx.doi.org/10.3390/toxins13010041.
Full textChichova, Mariela, Oskan Tasinov, Milena Shkodrova, Milena Mishonova, Iliyana Sazdova, Bilyana Ilieva, Dilyana Doncheva-Stoimenova, et al. "New Data on Cylindrospermopsin Toxicity." Toxins 13, no. 1 (January 8, 2021): 41. http://dx.doi.org/10.3390/toxins13010041.
Full textSeawright, Alan, Ross Norris, Glen Shaw, Michael Moore, and Vanessa Burgess. "Toxicity of the cyanobacterial toxin, cylindrospermopsin in mammals." Toxicology 148, no. 1 (July 2000): 75–76. http://dx.doi.org/10.1016/s0300-483x(00)90314-7.
Full textShaw, G., and P. K. S. Lam. "Health aspects of freshwater cyanobacterial toxins." Water Supply 7, no. 2 (July 1, 2007): 193–203. http://dx.doi.org/10.2166/ws.2007.054.
Full textPierangelini, Mattia, Rati Sinha, Anusuya Willis, Michele A. Burford, Philip T. Orr, John Beardall, and Brett A. Neilan. "Constitutive Cylindrospermopsin Pool Size in Cylindrospermopsis raciborskii under Different Light and CO2Partial Pressure Conditions." Applied and Environmental Microbiology 81, no. 9 (February 27, 2015): 3069–76. http://dx.doi.org/10.1128/aem.03556-14.
Full textFalfushynska, Halina, Nadiia Kasianchuk, Eduard Siemens, Eliana Henao, and Piotr Rzymski. "A Review of Common Cyanotoxins and Their Effects on Fish." Toxics 11, no. 2 (January 25, 2023): 118. http://dx.doi.org/10.3390/toxics11020118.
Full textChernoff, N., D. J. Hill, I. Chorus, D. L. Diggs, H. Huang, D. King, J. R. Lang, et al. "Cylindrospermopsin toxicity in mice following a 90-d oral exposure." Journal of Toxicology and Environmental Health, Part A 81, no. 13 (April 25, 2018): 549–66. http://dx.doi.org/10.1080/15287394.2018.1460787.
Full textEvans, Daniel M., Jack Hughes, Leigh F. Jones, Patrick J. Murphy, Halina Falfushynska, Oksana Horyn, Inna M. Sokolova, Jeppe Christensen, Simon J. Coles, and Piotr Rzymski. "Elucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach." Chemosphere 234 (November 2019): 139–47. http://dx.doi.org/10.1016/j.chemosphere.2019.06.021.
Full textAklakur, Md, Subham Bakli, Ashutosh D. Deo, D. K. Singh, and G. H. Pailan. "Cyanobacteria toxicity in aquaculture system and its impact on fish physiology." Journal of Aquaculture & Marine Biology 12, no. 1 (2023): 28–33. http://dx.doi.org/10.15406/jamb.2023.12.00353.
Full textDissertations / Theses on the topic "Cylindrospermopsin toxicity"
Bain, Peter A., and n/a. "Gene Expression Profiling of Cylindrospermopsin Toxicity." Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20080404.145834.
Full textBain, Peter A. "Gene Expression Profiling of Cylindrospermopsin Toxicity." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367068.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Faculty of Science, Environment, Engineering and Technology
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Blanco, Carlos Andrey González. "A non-targeted proteomics investigation of cylindrospermopsin-induced hepatotoxicity." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9143/tde-19102017-153400/.
Full textCianobactéria é o filo que mais se beneficia da crescente hipereutrofização das águas continentais. As florações de cianobactérias resultantes podem acumular potentes toxinas. A Cilindrospermopsina (CYN) é uma cianotoxina conhecida por inibir a síntese protéica e produzir estresse oxidativo, além de danos ao DNA em células eucarióticas. Os mecanismos moleculares e alvos de toxicidade aguda desta toxina ainda não são claros. Por esse motivo adoptamos uma abordagem de proteômica quantitativa baseada em descoberta para revelar as principais alterações nas células HepG2 em doses subletais de CYN (1 µM para 6, 12 e 24h). As proteinas dos hepatócitos foram marcadas metabolicamente, foram estimuladas com a toxina e os digestos trípticos foram analisados por espectrometria de massa em tandem de alta resolução (HRMS) no modo de aquisição dependente de dados. Escaneamos uma média de 4000 proteínas ao longo dos intervalos de tempo. A biosintese e transporte do colesterol foi inibida durante a maior parte do tratamento com a toxina. Proteínas e enzimas relacionadas com o processo de ubiquitinação (ex. UBE2L3) e proteólise (ex. PSMA2) foram inibidas, e alterações nas proteínas envolvidas nesses processos foram validadas por meio de Western Blot. Os processos de transcrição, tradução e ciclo celular mostraram uma dinâmica de regulação complexa, envolvendo reguladores e disruptores do ciclo celular como por exemplo PCNA. Danos à membrana mitocondrial e evidência de estresse oxidativo foram detectados após 6 horas de tratamento, e essas mudanças no proteoma foram validados por meio do corante JC-1 (test que detecta mudanças no potencial da membrana mitocondrial). O banco de dados resultante nos dá um primeiro vislumbre das proteinas afetados no estágio inicial da intoxicação celular pela CYN.
Froscio, Suzanne M. "Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phf938.pdf.
Full textJaja-Chimedza, Asha D. "Contribution of Lipophilic Secondary Metabolites to the Toxicity of Strains of Freshwater Cyanobacterial Harmful Algal Blooms, Identified Using the Zebrafish (Danio rerio) Embyo as a Model for Vertebrate Development." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1535.
Full text(9844961), Susan Kinnear. "Cylindrospermopsin in whole cell extracts and live cultures of Cylindrospermopsis raciborskii: Ecotoxicity, bioaccumulation and management." Thesis, 2006. https://figshare.com/articles/thesis/Cylindrospermopsin_in_whole_cell_extracts_and_live_cultures_of_Cylindrospermopsis_raciborskii_Ecotoxicity_bioaccumulation_and_management/13421693.
Full textFroscio, Suzanne Marie. "Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies / Suzanne M. Froscio." Thesis, 2002. http://hdl.handle.net/2440/21753.
Full textBibliography: leaves 121-139.
xvii, 139 leaves : ill. (some col.) ; 30 cm.
The aim of this study was to determine the extent to which protein synthesis inhibition, lowered glutathione (GSH) levels and toxin metabolism contribute to the toxicity of cyclindrospermopsin. Both hepatocyte cultures and reticulocyte lysates were utilized as in vitro tools of investigation. The findings imply that the inhibition of protein synthesis by direct action of the toxin cannot be considered a primary cause of hepatocyte cell death over an acute time frame. Cytochrome P450-derived metabolites may play a crucial role in cytotoxicity, and the toxicity process does not appear to involve oxidative damage.
Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2002?
Book chapters on the topic "Cylindrospermopsin toxicity"
"Cylindrospermopsin Toxicity." In Cyanobacterial Toxins of Drinking Water Supplies, 95–108. CRC Press, 2004. http://dx.doi.org/10.1201/9780203022870.ch6.
Full text"Cylindrospermopsin Toxicity." In Cyanobacterial Toxins of Drinking Water Supplies, 106–19. CRC Press, 2004. http://dx.doi.org/10.1201/9780203022870-12.
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