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Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Cyclopiazonic acid.'
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Journal articles on the topic "Cyclopiazonic acid":
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Peterson, Robert E., Gail M. Shannon, and Odette L. Shotwell. "Purification of Cyclopiazonic Acid by Liquid Chromatography." Journal of AOAC INTERNATIONAL 72, no. 2 (March 1, 1989): 332–35. http://dx.doi.org/10.1093/jaoac/72.2.332.
Abstract A purification procedure for cyclopiazonic acid has been developed, using sequential preparative and semi-preparative liquid chromatography. Crude cyclopiazonic acid (324 mg) was extracted from a 1 L fermentation medium with chloroform-methanol (80 + 20), dried, dissolved in chloroform, and chromatographed on an oxalic acid/ silica preparative column with chloroform-methanol (99 + 1) as the eluant. A semi-preparative oxalic acid/silica column and chloroform- methanol (99.5 + 0.5) were then used for rechromatography of the partially purified cyclopiazonic acid. This second chromatographic treatment yielded fractions from which cyclopiazonic acid was readily crystallized (106.7 mg; 33% recovery). Analytical chromatography was developed using an amino column in an ion-exchange mode, with a methanol-phosphate buffer eluant. Response was linear from 10 to 800 μg/injection of standard solutions. Cyclopiazonic acid chemically binds sodium from soda-lime vials.
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Chang-Yen, Ivan, and Keshore Bidasee. "Improved Spectrophotometric Determination of Cyclopiazonic Acid in Poultry Feed and Corn." Journal of AOAC INTERNATIONAL 73, no. 2 (March 1, 1990): 257–59. http://dx.doi.org/10.1093/jaoac/73.2.257.
Abstract An improved visible spectrophotometric method has been developed for cyclopiazonic acid in poultry feed and corn. The method Is based on the reaction of cyclopiazonic acid with Ehrlich reagent and detection at 580 nm. Reaction conditions were optimized with respect to reaction and measurement times and acid and Ehrlich reagent concentrations. Calibration curves were linear from 1 to 20 μg cyclopiazonic acid in 3 mL Ehrlich reagent, with a lower detection limit of 0.08 mg/kg for 50 g samples of poultry feed and corn. Recoveries from 50 g samples of poultry feed spiked with cyclopiazonic ranging from 0.16 to 1.20 mg/kg averaged 93.8%. Moldy corn and poultry feed samples analyzed by this method contained between 1 and 4 mg/kg cyclopiazonic acid.
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Matsudo, Takanao, and Masaoki Sasaki. "Simple Determination of Cyclopiazonic Acid." Bioscience, Biotechnology, and Biochemistry 59, no. 3 (January 1995): 355–57. http://dx.doi.org/10.1271/bbb.59.355.
Chang, P. K., and K. C. Ehrlich. "Cyclopiazonic acid biosynthesis byAspergillus flavus." Toxin Reviews 30, no. 2-3 (May 10, 2011): 79–89. http://dx.doi.org/10.3109/15569543.2011.576795.
van Rooyen, P. H. "Structure of α-cyclopiazonic acid." Acta Crystallographica Section C Crystal Structure Communications 48, no. 3 (March 15, 1992): 551–52. http://dx.doi.org/10.1107/s0108270191010053.
Diaz, G., W. Thompson, and P. Martos. "Stability of cyclopiazonic acid in solution." World Mycotoxin Journal 3, no. 1 (February 1, 2010): 25–33. http://dx.doi.org/10.3920/wmj2009.1170.
Cyclopiazonic acid (CPA) is an important mycotoxin given its toxicity and prevalence in foods and feeds. There is tremendous interest in developing analytical methods that include CPA as part of a multi-residue mycotoxin routine, but there appears to be considerable difficulty in analysing it using liquid chromatography with electrospray ionisation tandem mass spectrometry (LC-MS/MS). During the development of a multi-residue method for mycotoxins including CPA, a number of issues were discovered under routine and common analytical conditions that have an impact on the determination of CPA, including: (1) at the ng/ml level CPA reacts with ambient oxygen from the headspace of the vial, an effect that decreases its concentration linearly; (2) CPA readily adsorbs to plastic in a reversible fashion; (3) CPA is acid hydrolysed with formic acid; (4) CPA reacts with the column stationary phase affecting chromatographic parameters; and (5) CPA presents significant carry-over issues. In an effort to find solutions to these problems we found that CPA can be protected from reacting with oxygen by adding 1 µg/ml ascorbic acid and that its carry-over can be reduced to a negligible level by injecting ammonia between injections of solutions containing CPA, even with formic acid in the mobile phase. Chromatographic conditions for CPA have been optimised in consideration of all of the aforementioned concerns.
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Nishie, K., R. J. Cole, and J. W. Dorner. "Toxicity and neuropharmacology of cyclopiazonic acid." Food and Chemical Toxicology 23, no. 9 (September 1985): 831–39. http://dx.doi.org/10.1016/0278-6915(85)90284-4.
MUNIMBAZI, CÉLESTIN, JYOTI SAXENA, WEI-YUN J. TSAI, and LLOYD B. BULLERMAN. "Inhibition of Production of Cyclopiazonic Acid and Ochratoxin A by the Fungicide Iprodione‡." Journal of Food Protection 60, no. 7 (July 1, 1997): 849–52. http://dx.doi.org/10.4315/0362-028x-60.7.849.
Aspergillus flavus NRRL 1290 and Aspergillus ochraceus NRRL 3174 were grown on a glucose-salts medium and yeast extract-sucrose broth containing the fungicide iprodione at concentrations of 0, 1,3,5, 10, 15, and 20 μg of active ingredient per ml of growth medium. Cultures were analyzed for cyclopiazonic acid, ochratoxin A, and mycelium production after 4,7, 10, 14, and 21 days of incubation at 25°C. Increasing concentrations of iprodione in the growth media resulted in greater reduction of cyclopiazonic acid, ochratoxin A, and mycelium production at the end of each incubation period. More than 50% reduction of cyclopiazonic acid, ochratoxin A, and mycelium production was observed when iprodione was added to growth media at a concentration of 5 μg/ml of medium. Higher concentrations of iprodione (10 to 20 μg/ml of growth medium) inhibited the production of cyclopiazonic acid and mycelium by A. flavus NRRL 1290 almost completely, but not the production of ochratoxin A and mycelium by A. ochraceus NRRL 3174.
Moorthie, Vijayalakshmi A. "Studies towards a biomimetic synthesis of α-cyclopiazonic acid." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420913.
Boupha, Prasongsidh C., of Western Sydney Hawkesbury University, and Faculty of Science and Technology. "Fate of the neurotoxic mycotoxin, cyclopiazonic acid in dairy products." THESIS_FST_XXX_Boupha_P.xml, 1998. http://handle.uws.edu.au:8081/1959.7/184.
The aim of the study in this thesis was to assess the stability of the mycotoxin, cyclopiazonic acid (CPA) in milk and dairy products processed from contaminated milk. A method was developed to detect CPA in milk and milk products using micellar electrokinetic capillary chromatography (MEKC), a technique of capillary electrophoresis (CE), which was rapid and non-labour-intensive. The quantifying efficiency of CE in detecting CPA was compared to Reverse Phase Liquid Chromatography. Heat-stability of CPA in milk was assessed under different conditions. A longer heat treatment of 60 degrees centigrade for 30 minutes led to a 10% decrease in the level of CPA. The results from this thesis demonstrate that CPA in milk at concentrations found in naturally contaminated milk could not be eliminated by the heat-treatment during milk processing, storage, processing and manufacture of dairy products. Occurrence of CPA in cheese curd, butter or cream following manufacture with contaminated milk was demonstrated. CPA is left in milk despite UV-visible radiation treatment with or without hydrogen peroxide and/or riboflavin. Chemical treatment, which is capable of completely eliminating CPA, is prohibited and impractical to use for milk treatment. Stability of CPA in milk and milk products confirms the potential of the toxin to reach consumers of dairy products. Doctor of Philosophy (PhD)
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Boupha, Prasongsidh C. "Fate of the neurotoxic mycotoxin, cyclopiazonic acid in dairy products." Thesis, View thesis, 1998. http://handle.uws.edu.au:8081/1959.7/184.
The aim of the study in this thesis was to assess the stability of the mycotoxin, cyclopiazonic acid (CPA) in milk and dairy products processed from contaminated milk. A method was developed to detect CPA in milk and milk products using micellar electrokinetic capillary chromatography (MEKC), a technique of capillary electrophoresis (CE), which was rapid and non-labour-intensive. The quantifying efficiency of CE in detecting CPA was compared to Reverse Phase Liquid Chromatography. Heat-stability of CPA in milk was assessed under different conditions. A longer heat treatment of 60 degrees centigrade for 30 minutes led to a 10% decrease in the level of CPA. The results from this thesis demonstrate that CPA in milk at concentrations found in naturally contaminated milk could not be eliminated by the heat-treatment during milk processing, storage, processing and manufacture of dairy products. Occurrence of CPA in cheese curd, butter or cream following manufacture with contaminated milk was demonstrated. CPA is left in milk despite UV-visible radiation treatment with or without hydrogen peroxide and/or riboflavin. Chemical treatment, which is capable of completely eliminating CPA, is prohibited and impractical to use for milk treatment. Stability of CPA in milk and milk products confirms the potential of the toxin to reach consumers of dairy products.
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Boupha, Prasongsidh C. "Fate of the neurotoxic mycotoxin, cyclopiazonic acid in dairy products /." View thesis, 1998. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030801.153613/index.html.
Thesis (Ph.D.) -- University of Western Sydney, Hawkesbury, 1998. "A thesis presented to the University of Western Sydney for the degree of Doctor of Philosophy, September, 1998" Bibliography: leaves 193 - 219.
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Shaw, Michael A. "Studies Towards the First Asymmetric Total Synthesis of a-Cyclopiazonic Acid." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520663.
Craft, Russell S. "A radical cascade approach to the skeleton of α−Cyclopiazonic Acid." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/39782/.
3-Nitrophthalic acid 2.04 was transformed into 2.10 in 38% yield. Vinylglycine derivative was synthesised from D-Methionine 2.12 in 42% yield. (For image see abstract in pdf) Compounds 2.10 and 2.16 were coupled using Grubbs' 2nd generation catalyst creating 2.25. Unfortunately attempts to oxidise the benzylic position were unsuccessful. (For image see abstract in pdf) An alternative approach was investigated using diene 2.40 derived from a precursor to 2.10 and allyl bromide 2.35. Attempts to displace bromide under anionic conditions were futile. The use of palladium formed conjugated dieneamine 2.65. (For image see abstract in pdf) Deprotection, oxidation and elaboration of 2.10 prior to cross metathesis allowed the synthesis of 2.114, which when subjected to radical conditions, formed a diastereomeric mixture of 2.220. (For image see abstract in pdf).
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Amoako, Daniel Kwasi. "Cyclopiazonic acid changes the mode of excitation-contraction couplingin acetylcholine-stimulated bovine tracheal smooth muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B3121387X.
Amoako, Daniel Kwasi. "Cyclopiazonic acid changes the mode of excitation-contraction coupling in acetylcholine-stimulated bovine tracheal smooth muscle /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1865017X.
Mooney, Peter. "Biodegradation of the mycotoxins ochratoxin A, cyclopiazonic acid and fumonisin B1 by natural thermophilic microbial contaminants of self-heated maize." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273335.
Peden, W. Michael. "Effects of Cyclopiazonic Acid: Guinea Pig Skeletal Muscle." In Microbial Toxins in Foods and Feeds, 411–25. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0663-4_39.
Dorner, Joe W. "Recent Advances in Analytical Methodology for Cyclopiazonic Acid." In Advances in Experimental Medicine and Biology, 107–16. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0629-4_11.
Peden, W. M., J. L. Richard, and J. R. Thurston. "Comparative histopathologic changes in cyclopiazonic acid toxicosis and rubratoxicosis." In Diagnosis of Mycotoxicoses, 205–12. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4235-6_19.
Wilson, Mark E., Winston M. Hagler, John M. Cullen, Jon F. Ort, and Richard J. Cole. "Acute Toxicity of Cyclopiazonic Acid in Selected Avian Species." In Biodeterioration Research 2, 371–81. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5670-7_32.
Voss, Kenneth A. "In Vivo and In Vitro Toxicity of Cyclopiazonic Acid (CPA)." In Biodeterioration Research, 67–84. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9453-3_5.
Cole, Richard J. "Occurrence and clinical manifestations of rubratoxins A and B and cyclopiazonic acid." In Diagnosis of Mycotoxicoses, 91–99. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4235-6_9.
Heperkan, Dilek, and Funda Karbancioglu-Güler. "Determination ofAspergillussectionFlaviand their aflatoxin and cyclopiazonic acid production patterns in naturally dried figs." In ACS Symposium Series, 77–90. Washington DC: American Chemical Society, 2009. http://dx.doi.org/10.1021/bk-2009-1031.ch006.
Wilson, Mark E., Winston M. Hagler, Jon F. Ort, John M. Cullen, and Richard J. Cole. "Subacute Toxicity of Cyclopiazonic Acid in Broiler Chicks Fed Normal and High Zinc Diets." In Biodeterioration Research, 151–60. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9453-3_11.
Richard, J. L., W. M. Peden, and J. R. Thurston. "Combined Cyclopiazonic Acid and Aflatoxin B1 Effects on Serum Bacteriostasis, Complement Activity, Glycocholic Acid, and Enzymes and Histopathologic Changes in Guinea Pigs." In Microbial Toxins in Foods and Feeds, 441–49. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0663-4_41.
Conference papers on the topic "Cyclopiazonic acid":
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Lansdale, Nick, Marilyn G. Connell, Neil C. Featherstone, Angela Midgley, and Edwin C. Jesudason. "Cyclopiazonic Acid (CPA) Inhibition Of Sarco-Endoplasmic Reticulum Ca2+-ATPase (SERCA) Reduces, With Similar Dose-dependency, Prenatal Airway Branching, Peristalsis And Cell Proliferation And Modulates Gene Expression Required For Lung Development." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4140.
