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1

Masline, Shelagh Ryan. Celebrex: Cox-2 inhibitors--the amazing new pain fighters. New York: Avon Books, 1999.

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2

R, Vane John, Botting Regina M, William Harvey Research Conference (1997 : Phuket, Thailand), and William Harvey Research Conference (1998 : Boston, Mass.), eds. Clinical significance and potential of selective COX-2 inhibitors: The combined proceedings of the William Harvey Conferences held in Phuket, Thailand, on 18-19 September, 1997 and in Boston, USA, on 23-24 April, 1998, supported by an educational grant from Boehringer Ingelheim. London: William Harvey Press, 1998.

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3

The Cox-2 connection: Natural breakthrough treatment for arthritis, Alzheimer's, and cancer. Rochester, Vt: Healing Arts Press, 2001.

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4

E, Harris Randall, ed. Inflammation in the pathogenesis of chronic diseases: The COX-2 controversy. New York: Springer, 2007.

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5

G, Bazán Nicolás, Botting Jack H, and Vane John R, eds. New targets in inflammation: Inhibitors of COX-2 or adhesion molecules : proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim. Dordrecht: Kluwer Academic Publishers, 1996.

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6

Barragry, Thomas B. N.S.A.I.D.S./toxicity: COX 2 developments. [Dublin]: [University College Dublin, Department of Small Animal Studies], 1998.

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7

Vane, John R. Improved non-steroid anti-flammatory drugs COX-2 enzyme inhibitors: Proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Dordrecht: Kluwer Academic Publishers, 1996.

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8

William Harvey Conference (1995 London, England). Improved non-steroid anti-inflammatory drugs: COX-2 enzyme inhibitors : proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Dordrecht: Kluwer Academic, 1996.

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9

Vane, Sir John, ed. Clinical Significance And Potential Of Selective Cox-2 Inhibitors. WILLIAM HARVEY PRESS, 1998.

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10

Sir John R. Vane (Editor) and Jack H. Botting (Editor), eds. Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential. Springer, 1998.

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11

Botting, Jack H., and Sir John R. Vane. Selective COX-2 Inhibitors: Pharmacology, Clinical Effects and Therapeutic Potential. Springer, 2012.

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12

(Editor), Michel Pairet, and Joanne van Ryn (Editor), eds. COX-2 Inhibitors (Milestones in Drug Therapy). Birkhäuser Basel, 2004.

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13

Howardell, Maynard J. Trends in Cox-2 Inhibitor Research. Nova Science Publishers, 2006.

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14

Studies on meloxicam (Mobic) a cyclooxygenase inhibitor with selectivity towards COX-2. Oxford: Oxford University Press, 1996.

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15

Masline, Shelagh R. Celebrex :: Cox-2 Inhibitors--the Amazing New Pain Fighters. Avon, 1999.

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16

Selective COX-2 inhibitors: Pharmacology, clinical effects, and therapeutic potential : proceedings of a conference held on March 20-21, 1997, in Cannes, France. Dordrecht: Kluwer Academic, 1998.

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17

R, Vane John, Botting Jack H, and William Harvey Research Conference (1997 : Cannes, France), eds. Selective COX-2 inhibitors: Pharmacology, clinical effects and therapeutic potential : proceedings of a conference held on March 20-21, 1997, in Cannes, France. Dordrecht: Kluwer Academic, 1998.

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18

COX-2 Inhibitor Research. Nova Science Publishers, 2006.

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19

Howardell, Maynard J. Cox-2 Inhibitor Research. Nova Science Publishers, Incorporated, 2006.

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20

COX-2 blockade in cancer prevention and therapy. Totowa, N.J: Humana Press, 2003.

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21

Harris, Randall E. COX-2 Blockade in Cancer Prevention and Therapy. Humana Press, 2010.

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22

Harris, Randall E. COX-2 Blockade in Cancer Prevention and Therapy. Humana Press, 2002.

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23

LaValle, James B. The Cox-2 Connection: Natural Breakthrough Treatments for Arthritis, Alzheimer's, and Cancer. Healing Arts Press, 2001.

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24

(Editor), N. Bazan, Jack H. Botting (Editor), and Sir John R. Vane (Editor), eds. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules. Springer, 1996.

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25

(Editor), Joseph R. Bertino, R. N. Dubois (Editor), and Andrew J. Dannenberg (Editor), eds. Cox-2: A New Target for Cancer Prevention and Treatment (Progress in Experimental Tumor Research). S. Karger Publishers (USA), 2003.

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26

Harris, Randall E. Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy. Springer, 2010.

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27

Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy (Subcellular Biochemistry) (Subcellular Biochemistry). Springer, 2007.

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28

Simon, Lee S., and Marc C. Hochberg. Non-steroidal anti-inflammatory drugs. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0030.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse group of compounds that share three cardinal characteristics: they are anti-inflammatory, analgesic, and antipyretic. They are approved by regulatory authorities for the treatment of patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout, and some forms of juvenile idiopathic arthritis. There are at least 20 chemically different NSAIDs currently available in Europe and the United States. These include not only the ‘traditional’ non-selective cyclooxygenase (COX) inhibitors that inhibit both the COX-1 and COX-2 enzymes but also the COX-2 selective inhibitors. This chapter gives a background of NSAIDs, including the mechanism of action, pharmacology and adverse effects (including hypersensitivity and gastrointestinal, cardiovascular thrombotic, and renal adverse effects), before summarizing the use of NSAIDs in patients with osteoarthritis.
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29

Bazan, N., Jack H. Botting, and Sir John R. Vane. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules Proceedings of a Conference Held on April 15-16, 1996, in New Orleans, USA, Supported by an Educational Grant from Boehringer Ingelheim. Springer London, Limited, 2012.

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30

Bazan, N., Jack H. Botting, and Sir John R. Vane. New Targets in Inflammation: Inhibitors of COX-2 or Adhesion Molecules Proceedings of a Conference Held on April 15-16, 1996, in New Orleans, USA, Supported by an Educational Grant from Boehringer Ingelheim. Springer, 2012.

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