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Dissertations / Theses on the topic 'Cyclisation'

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1

Sukirthalingam, Sukanthini. "Palladium catalysed cyclisation processes." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335444.

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2

Chakraborty, Reena. "Cyclisation using bifunctional silanes." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335197.

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3

Wilmshurst, Martin Philip. "Fluoroalkyl radical cyclisation reactions." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286192.

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4

Bird, Andrew James. "Zirconium-mediated cyclisation reactions." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319766.

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5

Sykes, Bridget Maree. "Reductively triggered internal cyclisation reactions." Thesis, University of Auckland, 1994. http://hdl.handle.net/2292/1977.

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Reductively triggered internal cyclisation reactions have been investigated as a prodrug system for the hypoxia selective release of aromatic nitrogen mustards. The observed pseudo-first-order rate coefficients of cyclisation of several model 2-aminoaryl-acetamides and propanamides have been measured. Cyclisation was observed to be strongly influenced by stereochemistry, whereas electron withdrawal from the amine-bearing ring resulted in a comparatively modest slowing of the rate of cyclisation. Protonation of the leaving group appeared to increase the rate of cyclisation, while changes in 4-s
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6

Nilsson, Paul Andrew. "Radical cyclisation reactions of carbonyls." Thesis, Brunel University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270101.

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7

Pilling, Adam Wesley. "Site Isolation in Cyclisation Cascades." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492762.

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This thesis concerns the exploitation of the site isolation concept in cascade sequences that facilitate rapid construction of complex polycyclic molecules. Site isolation is the anchoring of mutually destructive reagents onto solid supports to prevent their mutual deactivation.
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8

Nodes, William. "Novel intramolecular organocatalytic cyclisation reactions." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541961.

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9

Young, Adrian R. "Free radical cyclisation of imines." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/15357.

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Introduction. The free radical cyclisation reaction onto an unsaturated bond is a well known synthetic pathway, where a wide range of cyclic compounds can be produced form acyclic starting materials. Up until recent years, free radical addition to multiple bonds other than carbon-carbon had been little studied. Nowadays there is much information available of radical addition to carbonyl, thiocarbonyl, nitrile and oxime ether (C=NOR) functional groups. However there has been surprisingly little detailed study of similar reactions involving imines (C=NR) or hydrazones (C=NNHR). Monocyclisation.
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10

Cecil, Alexander Richard Liam. "Asymmetric oxidative cyclisation of dienes." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402065.

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11

Owen, David Rodney. "Zirconocene mediated co-cyclisation reactions." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313216.

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12

Drayton, Sally Katherine. "Palladium-catalysed cyclisation of allylic esters." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358604.

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13

Murphy, Nicholas Patrick. "Radical aromatic cyclisation and substitution reactions." Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/2286/.

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This dissertation is divided into five chapters. Chapter One consists of an introduction to radical cyclisation and rearrangement reactions. Chapter Two investigates the reactions of substituted arylsulfonamides 278a-l with copper bromide and an amine ligand-TPA. This reaction involves an alkyl radical generated from the copper (I) bromide/TPA complex, which can then undergo a 1,5- ipso attack onto the sulfonamide leading to a cyclohexadienyl radical intermediate. Re-aromatisation and extrusion of sulfur dioxide leads to an amidyl radical intermediate. This can undergo either cyclisation back
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14

Burns, Barry. "Palladium catalysed cyclisation anion capture process." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334562.

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15

Rajviroongit, Shuleewan. "Cyclisation and cycloaddition of imine derivatives." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335436.

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16

Gleasure, A. J. "Ruthenium and palladium catalysed cyclisation reactions." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246436.

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17

Coulter, Thomas Stephen. "Combined cycloaddition - palladium catalysed cyclisation processes." Thesis, University of Leeds, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305704.

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18

Moore, Peter Robert. "Organic synthesis through radical cyclisation reactions." Thesis, University of Exeter, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337802.

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19

McLaughlin, Mark. "Studies on the Khand cyclisation reaction." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248357.

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20

Goodall, Karen. "A radical cyclisation approach to pyroglutamates." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337153.

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21

Penfold, David John. "Novel radical and palladium cyclisation reactions." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266525.

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22

Avcil, Muhammet. "Investigation of novel thermal cyclisation reactions." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/47138/.

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[For full abstract, with illustrations, see pdf file]. Part 1. Concise Synthesis of Highly Substituted Isoquinolin-1(2H)-ones via IMDA The primary goal of this DPhil research project was to further investigate the mechanism of a novel thermally activated cyclisation reaction discovered within the Parsons' research group. Through the synthesis and cyclisation of the substituted pyrrole rings 2.38a-c we have investigated the mechanism and increased the scope of the cyclisation reaction. We have also developed a robust route to advanced intermediate 2.10 in the synthesis of hymenialdisine 2.1. Pa
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23

Warner, Andrew. "Borylative cyclisation of alkynes using BCl3." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/borylative-cyclisation-of-alkynes-using-bcl3(7a4e56f3-e8c6-4c68-97ec-4596ef5e0ce2).html.

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Boron trichloride, a cheap and commercially available Lewis acid, has been demonstrated to activate alkynes possessing appropriate nucleophiles, facilitating borylative cyclisation. This reaction furnishes polycyclic compounds possessing a new C(sp2)-B bond externally to the newly formed ring (through concomitant C-C and C-B bond formation). The RBCl2 intermediates generated from cyclisation were esterified with pinacol to furnish air/moisture stable boronic esters. This methodology has been applied to the following classes of starting materials: 1,4-disubstituted but-1-ynes (including N- and
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24

BOUZIDE, ABDERRAHIM. "Nouvelles reactions de cyclisation des enamines." Paris 6, 1993. http://www.theses.fr/1993PA066321.

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Deux nouvelles reactions de cyclisation des enamines ont ete mises au point au cours de ce travail: 1) une reaction de cyclisation radicalaire oxydante induite par les sels de metaux; 2) une ene cyclisation thermique. Ces deux reactions appliquees aux beta-carboxamidoenamines secondaires ou tertiaires permettent d'obtenir en une etape le squelette de base de nombreux produits naturels; i) les enamines insaturees soumises a l'action de sels de metaux se transforment rapidement en produits azaspiraniques avec de bons rendements. Cette reaction appliquee a des beta-carboxamidoenamines ou des beta
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25

Gregory, Alexander William. "Cyclisation cascades via reactive iminium intermediates." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8e633fee-3457-4c31-939c-4421fac2fb8f.

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The aim of this D.Phil was to develop a range of cyclisation cascades, which initially form a reactive iminium intermediates that can then be attacked by a pendant nucleophile resulting in novel polycyclic structures. This concept has been applied to the development of three methodologies and has resulted in the discovery of new reactivity as well as the synthesis of a wide range of interesting novel structures <b>Chapter 1: Enantioselective chiral-BINOL-phosphoric acid catalysed reaction cascade</b> A highly enantioselective hydroamination / N-sulfonyliminium cyclisation cascade using a combi
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26

Outin, Johanne. "Synthèse de composés polycycliques azotés par cyclisation de Vilsmeier-Haack et cyclisation de Mannich organocatalysée en séquence." Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/10979.

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Les recherches présentées dans cette thèse découlent de problématiques rencontrées lors de précédents travaux effectués dans notre groupe au sujet de cyclisations séquentielles de Vilsmeier-Haack et de Mannich par une activation chimiosélective d’amides. Deux limitations avaient été soulevées : une faible réactivité lors de la seconde cyclisation de Mannich et aucune possibilité d’obtention de produit de double cyclisation de façon énantiosélective. Au chapitre un, une étude de double cyclisation de Vilsmeier-Haack et de Mannich est présentée, tout d’abord sur des substrats allylsilane-aldé
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27

Pecheux, Muriel. "Cyclisation reactions mediated by sulfur-stabilised cations." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481499.

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28

El-Sayed, Nahed Nasser Eid. "Cyclisation desymmetrisation reactions of cyclohexa-1,4-dienes." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/56053/.

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This thesis describes different strategies to desymmetrise 1,4-cyclohexadiene derivatives with concomitant formation of a quaternary stereogenic centre. Chapter 1 gives a brief overview of the previous desymmetrisation and diastereotopic group selection processes of 1,4-cyclohexadiene derivatives. Chapter 2 describes the initial model studies for the formation of the quaternary stereogenic centre using achiral cyclohexa-1,4-dienone derivatives. This was developed to permit stereoselective formation of a quaternary stereogenic centre using a chiral sulfinyl group as the stereodirecting influenc
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29

O'Neill, William. "New and novel cyclisation reactions of imidoylketenes." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3124.

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The effect of scale on the conversion to products in flash vacuum pyrolysis experiments was studied using four model reactions. Overall, conversion was dependent on rection scale up to 0.5 g, but above 0.5 g, the effect was minimal and within experimental error. This effect was shown to be due to variations in contact time of the molecules in the furnace tube. Altering the furnace tube diameter had the effect of increasing the conversion to product. The pyrolysis of ortho-anilinomethylene Meldrum’s acid derivatives was investigated. Typically the 8-substituted quinolin-4-one was obtained as th
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30

Yang, Ting. "Transition metal ion catalysed alkyne cyclisation reactions." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505491.

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31

Hughes, D. D. "The synthesis and oxidative cyclisation of lignans." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637339.

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The work described in this thesis outlines the achiral synthesis of lignans and their oxidation. Chapter one classifies lignans and examines their natural occurrence and biological activities. The biosynthesis and synthesis of lignans is also reviewed. Chapter two describes the selective synthesis of <I>trans</I>-dibenzylbutyrolactone lignans. Tandem conjugate addition to 2(5<I>H</I>)-furanone utilising diphenyl thioacteals as acyl anion equivalents, followed by <I>in situ</I> trapping with aromatic benzyl bromides, afforded the adducts in good yields. Desulfurisation yielded the <I>trans</I>-
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32

Carlisle, J. "Thermodynamically controlled cyclisation reactions with phenylsulfanyl participation." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597292.

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Treatment of b-phenylsulfanyl alcohols with acid results in the formation of episulfonium ions. These can be trapped intramolecularly to produce heterocycles. These reactions are under thermodynamic control. This thesis describes the synthesis and subsequent cyclisation of tetrols. In this case there is competition between two episulfonium ions and between two possible secondary hydroxyl nucleophiles. The cyclisation of compounds in which two episulfonium ions can form at the same centre, is also investigated. Finally, the interaction between the ring size (5-<i>vs </i>6-membered) and sulfur a
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33

Battle, Gary Michael. "Copper mediated atom transfer radical cyclisation reactions." Thesis, University of Warwick, 2002. http://wrap.warwick.ac.uk/66931/.

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The effect of different N-pentyl-2-pyridylmethanimine (NPMI) derivatives upon the rate of copper(I) mediated atom transfer radical cyclisation (ATRC) of mono-bromo- and trichloro-acetamides were investigated. 6-Functionalised NPMI derivatives retarded the rate of ATRC due to steric effects, while for the 5-substituted analogues, inductively increasing the electron density of the pyridine nitrogen increased the rate of ATRC. Multidentate amine derived copper(l) halide complexes were found to mediate the ATRC of I-halo-N-propargylacetamides. The cyclisation of trichloro- and dichloroacetamide pr
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34

Tinkl, Michael. "Stereocontrolled iron-mediated cyclisation routes to heterocyles." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358562.

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35

Thompson, David Francis. "Iron (III) mediated ring expansion / cyclisation reactions." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297007.

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36

Amjad, ʿAlī. "Cobalt-mediated cascade cyclisation reactions in synthesis." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357981.

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37

Roan, Graeme A. "Cobalt-mediated radical and cationic cyclisation reactions." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336865.

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38

Snowden, David John. "Stereoselective bicyclic amine synthesis by anionic cyclisation." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264609.

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39

Peron, Guillaume Luc Nicolas. "Lewis acid mediated cyclisation of methylenecyclopropane derivatives." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326304.

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40

Mares, Richard W. "New cyclisation reactions of 3-aminopyrazole derivatives." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/15263.

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Three synthetic routes to cyclised pyrazole derivatives were investigated:- The first route was based on the chemistry of 2,3-diaminopyrazoles. Reactions with various electrophiles were carried out and some cyclised products were obtained. An important reaction with carbon disulphide was carried out and this resulted in the formation of the photographically important pyrazolo[1,5-<i>b</i>]1,2,4-triazole ring system. The second route explored the chemistry of 3-acetamidopyrazoles. Monoacylation of 3-aminopyrazoles was found to give a mixture of 1- and 2-acylated aminopyrazoles. The mixture surp
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41

Groundwater, Paul William. "Cyclisation reactions of diene-conjugated nitrile ylides." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/12066.

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42

Bedjeguelal, Karim. "Cyclisation par voie organométallique en série sucre." Lyon 1, 2000. http://www.theses.fr/2000LYO19005.

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43

Pillai, Jayasheela. "Heterocycle synthesis by hydrogen atom transfer and cyclisation." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298644.

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44

Brown, Paul. "Tandem Michael/aldol and Michael/Michael cyclisation reactions." Thesis, Bangor University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429866.

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45

Potter, Gavin R. "The synthesis and cyclisation reactions of trifluoropropynyl compounds." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492922.

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46

Shrivastava, Rajeev Kumar. "Synthesis of cyclohexanes via a radical cyclisation reaction." Thesis, University of Sunderland, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270377.

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47

Fletcher, Rodney Justin. "Radical cyclisation in routes to cis-fused heterocycles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283701.

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48

Boehm, Haydn M. "Tandem radical cascade cyclisation reactions in steroid synthesis." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364673.

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49

Newman, Nicola Ann. "Cyclisation strategies towards the synthesis of natural products." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342637.

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50

Barry, Conor. "Clavosolide A : Prins cyclisation in natural product synthesis." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413614.

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