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Mettam, Colin. "Nutrient cycling and oxygen availability in ancient oceans : extinction events and evolutionary opportunities." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16334.
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Cole, Andrew. "The response of grassland carbon cycling to drought events and changes in nutrient availability." Thesis, Lancaster University, 2016. http://eprints.lancs.ac.uk/86756/.
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In grasslands, climate change has the potential to disrupt a range of ecosystem services, including agricultural production, carbon (C) storage and nutrient cycling. In particular, climate change is likely to increase the frequency and severity of extreme climate events, such as drought and the subsequent rewetting event. Yet the effect of drought events will not be consistent across grassland communities, instead likely varying with grassland properties. One such property may be the level of nutrient availability, which brings about changes in plant productivity, plant community composition, and soil microbial composition and function. In this thesis, the effect of reduced precipitation on C cycling in UK species-rich grasslands is investigated in two field experiments, with varying long-term grassland restoration treatments and short-term nutrient addition, and a glasshouse experiment with reduced soil moisture. It was hypothesised that changes in plant and soil microbial communities, brought about by differences in nutrient availability, would modulate above and belowground C cycling responses to drought. This thesis found that the level of nutrient availability was important for modulating how C is cycled in response to drought in plants, soil microbial communities and whole ecosystem CO2 fluxes. For plants, the effect of drought and nutrient availability differed between functional groups, species and due to intraspecific trait variation. For soil microbial communities, the effect of drought on carbon use efficiency was modulated by short-term nutrient addition. Increased nutrient availability and drought therefore interact to determine how C is cycled and stored in plants and soil microbial communities, revealing the importance of agricultural practices in modulating whole community responses to climate change. Overall, this thesis shows the mechanisms by which drought may alter C cycling and its potential feedbacks to climate are complex, but at least in part, depend on the level of nutrient availability.
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Hülse, Dominik. "Marine biogeochemical cycling during extreme climate events : exploring the importance of benthic-pelagic processes with models." Thesis, University of Bristol, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738320.
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Zheng, Xinyuan. "Oceanic cycling of rare earth elements and the application of Nd isotopes to assess changes in Mesozoic ocean circulation." Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:0b06129a-8f51-4421-a043-5eeb86cec972.
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Rare earth elements (REEs) and their isotopes (such as Nd isotopes) can be potentially used to trace a wide range of oceanic processes in both modern and ancient oceans, but their successful application as tracers requires a comprehensive understanding of REE cycling in the modern ocean. Previous studies of REEs in seawater were largely constrained by analytical difficulties in generating accurate and precise REE data from seawater, which typically contain REE concentrations at a sub-ppt to ppt level. A new, and relatively simple, analytical method for precise and accurate determination of all dissolved REE concentrations in reasonably small (∼100 ml) seawater samples is presented in this thesis. With the application of the new method, this thesis reports the first full-depth, zonal ocean section of all dissolved REE concentrations, collected during the CoFeMUG cruise along ∼12°S in the South Atlantic. The section approach of this study places the distribution of dissolved REE concentrations in a well-constrained hydrographic context, allowing the first quantitative assessment (by an inverse model) of the relative importance of hydrographic controls resulting from advection/mixing of ocean circulation, together with non-conservative controls resulting from local particle scavenging and remineralization, in controlling the distribution of dissolved REEs in this region. A noteworthy decoupling of Ce and Mn with respect to their cycling in the water column was also observed in this study. The application of Nd isotopes as a tracer to reconstruct changes in ocean circulation in the NW European chalk shelf sea during rapid climatic events, including the mid-Cenomanian Event and oceanic anoxic event 2 (OAE 2), suggests a tight coupling between ocean circulation and transient climatic cooling during the general warm Late Cretaceous. An advected volcanic signal during OAE 2 was registered in the seawater Nd-isotope record from the English Chalk, probably suggesting a period of enhanced ocean ventilation/mixing at this time.
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Asrar, Ahmad Malik. "Testing the cell cycle phase specificity of cyclins: can an earlier cyclin trigger a later event?" Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/127221.
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Progression through the cell cycle is directed by cyclin dependent kinases (CDKs), which are essential for normal and cancer cell proliferation. CDKs are activated by association with cyclins specific to each cell cycle phase (G1, S, G2, and M). Thus, CDK associated with G1 phase cyclins promote the expression of proteins necessary for DNA replication, but is unable to activate it. CDK associated with S phase cyclins, in turn, triggers the activation of chromosomal origins of replication, but is unable to promote chromosome condensation and segregation of sister chromatids, which is carried out by CDK associated with mitotic cyclins.
Despite the essential role of CDKs in cell cycle progression, how the different cyclins promote specifically the various processes of the cell cycle was still an open question by the time this thesis was initiated. Since the discovery of cyclins by Nobel laureate Tim Hunt [Evans et al. (1983) Cell 33:389] it was assumed that cyclins confer substrate specificity. However, later on, fellow Nobel laureate Paul Nurse proposed an alternative quantitative model, [Stern & Nurse (1996) Trends Genet 12:345], based on the observation that successive waves of cyclins result in increased levels of CDK activity. While low levels of activity (CDK associated with G1 cyclins) are sufficient promote progression through the G1 phase and start the pro-S phase transcription program, would be unable to trigger replication. Moderate levels of activity (CDK associated with S phase cyclins) would be able to activate replication but not mitosic events, which would require the high CDK activity associated with M phase cyclins.
If correct, the quantitative model should fulfill two predictions, but only one was demonstrated by the Nurse lab. Eukaryotic unicellular yeast cells are able to survive with a single mitotic cyclin, which is notwithstanding able to orderly drive the cell through the different cell cycle phases [Fisher & Nurse (1996) EMBO J 15:850]. Therefore M-CDK activity is able to promote the previous phases of the cycle in the fission yeast Schizosaccharomyces pombe However, if a purely quantitative mechanism applies, the complementary prediction should be true as well: an early cyclin to be able to trigger later events if expressed at levels high enough.
To test such prediction we generated a budding yeast Saccharomyces cerevisiae strain carrying a G1 cyclin G1 resistant to degradation, under a strong inducible promoter, and fused to a nuclear localization signal. Our results show that one such cyclin is capable of firing chromosome replication conditions in which the S phase cyclins, G2 and M are suppressed. Therefore, our results support the quantitative model against the requirement of substrate specificity. How eukaryotic cells prevent premature activation of the critical cell cycle processes that lead to genomic instability, seems therefore trust in the regulation of activity levels and limiting the presence of cyclin at specific time and space.
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Gong, Delquin. "Regulation of early mitotic events by cyclin A2 and cyclin B1/." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
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Olson, Karl E. "VeloCal a web-based cycling event scheduler /." [Denver, Colo.] : Regis University, 2006. http://165.236.235.140/lib/kolson2006.pdf.
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Herzet, Cyril. "Hosting Tour De France Under Covid-19: Bargain Or Burden For New Stage Cities?" Thesis, Umeå universitet, Institutionen för geografi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185193.
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The Tour De France (TDF) is the third largest sporting event in the world and the biggest cycling race in terms of popularity and prestige. The event generates global media exposure and attracts millions of short- and long-term visitors each year, thus, TDF is extremely appealing for communities in search of profits. Using Linear Directional Mean (LDM) and semi-structured interviews (community and organization sides), this paper analyzes how TDF has spatially evolved through time by comparing the 2021 racetrack to other time intervals. Additionally, reasons of the potential shift in terms of spatial distribution are investigated considering current issues due to the COVID-19 pandemic that has severely affected the tourism sector and therefore, the benefits that communities were expecting to perceive by hosting TDF. Findings showed that the 2021 route deviated from previous editions time of the TDF history including 10 new stage cities that never hosted the event before. The respondent from the organization indicated the pandemic only indirectly affected the TDF route and that the location of the Grand Départ as well as the main internal constraints imposed to the organizers are key elements in the spatial distribution of the event. Interviewed communities acknowledged that there was risk while hosting TDF this year due to potential restrictive measures. However, they recognized that benefits brought by the race largely overweight potential negative impacts from the epidemic. Indeed, TDF remains a way to bring economic benefits, social cohesion, happiness, pride and satisfaction to hosting cities at a time when the tourism industry is at a standstill.Le Tour de France (TDF) est le troisième événement sportif au monde et la plus grande course cycliste en termes de popularité et de prestige. L’événement génère une exposition médiatique mondiale et attire chaque année des millions de visiteurs à court et à long terme. Le TDF est donc extrêmement attrayant pour les communautés à la recherche de profits. À l’aide de la Direction Moyenne Linéaire (MLD) et d’interviews semi-structurées (côté communauté et organisation), ce mémoire analyse l’évolution spatiale du TDF au fil du temps en comparant le parcours de 2021 à d’autres intervalles temporelles de la course. En outre, les raisons du changement potentiel en termes de distribution spatiale sont étudiées en tenant compte des problèmes actuels dus à la pandémie de COVID-19 ayant gravement affecté le secteur du tourisme et, par conséquent, les avantages que les communautés espéraient percevoir en accueillant le TDF. Les résultats ont montré que l’itinéraire de 2021 s’écarte des éditions précédentes de l’histoire du TDF en incluant 10 nouvelles villes étapes qui n’ont jamais accueilli l’événement auparavant. Le répondant de l’organisation a indiqué que la pandémie n’a affecté qu’indirectement le parcours du TDF et que l’emplacement du Grand Départ ainsi que les principales contraintes internes imposées aux organisateurs sont des éléments clés dans la répartition spatiale de l’événement. Les communautés interrogées ont reconnu qu’il y avait un risque à accueillir le TDF cette année en raison des mesures restrictives potentielles. Cependant, elles ont admis que les bénéfices apportés par la course surpassaient largement les impacts négatifs potentiels dus à l’épidémie. En effet, le TDF reste un moyen d’apporter des effets économiques positifs, de la cohésion sociale, du bonheur, de la fierté et de la satisfaction aux villes hôtes à un moment où l’industrie du tourisme est au point mort.
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Wolfe, Jennifer Marie. "Historic context at risk planning for tropical cyclone events in historic Cedar Key /." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0016180.
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Them, II Theodore Roland. "Biogeochemical Cycling and Paleoenvironmental Reconstructions of the Toarcian Oceanic Anoxic Event from Western North America." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81908.
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The Toarcian Oceanic Anoxic Event (T-OAE; ~183 million years ago) represents an interval during the Mesozoic when the emplacement of the Karoo-Ferrar Large Igneous Province (LIP) is thought to have resulted in significant environmental change. Associated with this interval was the widespread deposition of organic-rich sediments, carbon cycle and seawater chemistry changes, global warming, the development of marine anoxia, and major extinction events. The majority of studies of this event that have documented these responses have come from the Boreal and Tethyan regions of Europe, thus casting some doubt to the regional versus global significance of the event. Thus my dissertation has sought to reconstruct biogeochemical and paleoenvironmental changes across the T-OAE from a sedimentary succession that was deposited on the margins of a different ocean basin away from the well-studied European successions. Specifically, I have studied the chemostratigraphy of the Fernie Formation of the Western Canada Sedimentary Basin (WCSB), which was deposited on the eastern margin of the Panthalassa Ocean. The Toarcian carbon isotope excursions (CIEs) in the WCSB confirm that these features are global phenomena. I have suggested a new driver for small-scale CIEs observed during the event: the release of wetland-derived methane during progressive global warming. The osmium isotope record and numerical modeling of the osmium cycle suggests that continental weathering rates increased during the T-OAE by 230 – 540%. Rhenium abundance data also suggests that the increased geographic extent of marine anoxia during the T-OAE caused a global drawdown in the seawater rhenium inventory. Iron speciation data are used to reconstruct redox conditions within the WCSB, which suggest ferruginous conditions developed in the more distal locations at the onset of the T-OAE before returning to euxinic (anoxic and sulfidic) conditions. This is likely related to enhanced pyrite burial on a global scale, which caused the drawdown of the seawater sulfate inventory, thus limiting pyrite formation in the distal locations. The proximal setting remained euxinic across the T-OAE, and in all locations the iron speciation data suggest anoxic conditions persistent well after the interval that has been traditionally called the end of the T-OAE.Ph. D.
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Dutra, Lívia Márcia Mosso. "Ciclones subtropicais sobre o Atlântico Sul: análise da estrutura dinâmica de eventos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/14/14133/tde-14052012-132233/.
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Neste trabalho, o objetivo geral é investigar os processos sinóticos, dinâmicos e termodinâmicos de dois ciclones subtropicais ocorridos no Atlântico Sul. Utilizou-se um algoritmo de rastreamento de máximos de vorticidade ciclônica e o algoritmo Cyclone Phase Space (CPS), que permite classificar o ciclo de vida dos ciclones. Desenvolveu-se um processo de automatização destes algoritmos, que possibilitou a análise dos diagramas de fase de todos os ciclones ocorridos no Atlântico Subtropical durante 2008, 2009 e março de 2010. As condições sinóticas para dois eventos foram analisadas desde o período prévio à formação até o decaimento dos sistemas, e as equações do balanço de vorticidade e de calor foram utilizadas para investigar os processos dinâmicos e termodinâmicos. Embora com fraca intensidade em termos de pressão central, os ciclones tiveram impacto importante nas condições de tempo sobre suas regiões de atuação, e os ventos máximos superaram 15 m/s em 925 hPa por várias horas. Ambos os ciclones apresentaram, ao menos em algum tempo de sua fase subtropical, um pico de advecção horizontal quente em altos níveis, enquanto a advecção horizontal quente em baixos níveis apresentou fraca intensidade. Nos estágios de fase híbrida, o termo diabático foi responsável pelas tendências de aquecimento em baixos níveis. Já durante a fase de transição extratropical ocorrida em um dos ciclones, o sentido dos fluxos turbulentos em superfície se inverteu e o termo diabático passou a contribuir para tendências de resfriamento em baixos níveis. Em altos níveis, foram encontradas regiões em que altos valores positivos do termo diabático da equação da termodinâmica correspondem a regiões de intenso resíduo negativo da equação da vorticidade. Nestas regiões, os processos convectivos podem explicar os imbalanços de vorticidade. Nas demais regiões e níveis em que esta relação não ocorreu, sugere-se que a convecção influencia as variações locais de vorticidade de uma forma mais distribuída na coluna atmosférica, assim como a divergência associada aos movimentos verticais pode ocorrer de forma distribuída ao longo da troposfera.This work aims to investigate the synoptic and dynamic processes of a sample of subtropical cyclones that occurred near the east coast of South America. A cyclonic vorticity maximum tracking algorithm and the Cyclone Phase Space (CPS) algorithm are used to track and to classify the life cycle evolution of the cyclones. By automating these algorithms, it was possible to perform the analysis of the phase diagrams of all the cyclones occurred in the Subtropical Atlantic during 2008, 2009 and March 2010. The synoptic conditions for two events were analyzed from the period prior to the genesis until the decay of the systems, and the heat and vorticity balance equations were used to investigate the thermodynamic and dynamic processes. Although with low intensity in terms of central pressure, the cyclones had a major impact on the weather conditions in their regions of occurrence, and the 925 hPa maximum sustained winds exceeded 15 m/s for several hours. Both selected cyclones, at least at a time of its subtropical phase, had a peak of warm horizontal advection at higher levels, whilst the warm horizontal advection at lower levels showed weak intensity. In the hybrid stages of both cyclones, the diabatic term was responsible for warming trends at low levels. However, during the extratropical transition in one of the cyclones, the direction of the near-surface turbulent fluxes reversed and the diabatic term began to contribute to cooling trends at low levels. In the upper troposphere, it was found that in some regions that featured large positive values of the thermodynamic equation diabatic term, there was also a significant negative residual of the vorticity equation. In these regions, the convective processes can explain the observed vorticity imbalances. For other regions and levels, at which there was no direct relationship between the residual fields, it is suggested here that convection influences the local variations of vorticity in a more distributed way in the atmospheric column, as well as the divergence associated with the vertical velocities can be more distributed throughout the troposphere, without being concentrated at only some levels.
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Hallros, Jessica. "Marketingplan for Vätternrundan." Thesis, University of Gävle, Department of Business Administration and Economics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-783.
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Aim: Vätternrundan is one of three cycling rides organised yearly in Motala,Sweden. It is one of the world’s largest cycling events in number of participants, but staying at the top requires constant reinvention and reconfiguration. The purpose of this study is to formulate a strategic marketing plan for the business unit Vätternrunda answering the following questions for effectiv marketing management.
- How can competitive advantage be achieved?
- What is the holistic current situation of the business?
- What marketing strategy can and should be used?
Method: The work of formulating a plan is a creative process involving analysis of internal data, supplemented by market research. Empirical data has been collected from secondary sources such as existing documents and earlier studies complemented by the researchers observations, experiences and interviews with key actors.
Result & Conclusions: The results show a growing potential market, provided that it is properly targeted. The strategies possible are brand strengthening, product development and differentiation. Of great importance is also internal marketing and partner relationship development. The key to effective implementation is the organizational capabilities and core competence.
Suggestions for future research: How to amplify the efficiency of an organization where social and profit-making objectives meet.
Contribution of the thesis: The study brings strategic guidance to the company being studied but also additional knowledge of the market for other similar events as well as being a case study of possible interest to fellow academics.
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Cihan, Maroš. "Ekonómia dopingu v cyklistike: Dopingové kauzy a ich vplyv na hodnotu akcií sponzorov." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198239.
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The main goal of the paper was the impact of negative events, in our case doping cases, on sponsors of cycling teams and riders. It also discuss view of spectators and fans on doping and sponsorship. As a method it's used an event study, which measure the impact of event on market value of firms in time of the event. In the paper are built three models, which analyse different doping cases and their impact on sponsors firms. All three models didn't show significant negative impact on market value of sponzoring firms.
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Hanumegowda, Umesh M. "CREB mediated events in normal and secalonic acid D altered palate development in mice /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012973.
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Dettori, Joseph R. "Erectile dysfunction following a long-distance cycling event : is there an increased risk and what bicycle characteristics might contribute? /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/10937.
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Handlon, Sarah F. "Determination of the within event variability and the influence of seasonality on nutrient cycling processes within a green roof." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553513890942554.
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Christiansen, Anna P. "The Underground Gang: Cyclist Group Identity as Expressed Throughout Folk Art, Folk Events, Narratives, and Community Spaces." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4467.
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This thesis is a study of the “underground” cycling community in Ogden, Utah. Countercultural cycling micro-communities exist across the United States, if not the world, but have not yet been thoroughly studied by folklorists. This research establishes a foundational understanding of the nature of underground cycling culture, particularly in relation to identity. Using folkloric definitions of identity and subculture as my foundation, I examine four different facets of cyclist activities: folk art, folk events, narratives, and the community’s use of space. These four facets provide a variety of lenses through with to examine actualized, expressive cyclist behavior. Each facet also illustrates the different levels (personal, community, and global) at which identity is performed.
The most personal performances of cyclist identity are through the folk art of modified bicycles. Modifications tend to reflect the personality of the cyclist, and consequently a bicycle comes to hold much symbolism for the cyclist. The communitylevel studies consisted of examining group events where I observed how the group interacted with itself. The performance and participation in activities are what constitutes an actual cycling community, rather than a series of individual cyclists.
The examination of narratives moves outward to contextualize the cycling microcommunity within the larger Ogden community. This chapter explores the role of conflict, illustrates how cyclists think of themselves, and illustrates how cyclists define themselves in opposition to motorists.
The community spaces examination looks at the use of physical space versus digital space. These spaces illustrate how the community behaves amongst itself versus how the community behaves amongst the larger, online, Utah cycling community. The physical space reflected the creativity and utilitarian needs of the group. The restrictive digital spaces manage to be expressive through images and language. Internal group conflict occurs more often online, however, due to infractions of implicit group etiquette, possibly as a symptom of a less personal form of interaction.
The marginalized, cyclist identity seemed to hold the greatest rewards at the more intimate, personal levels. Moving outward towards broader community-level contests, cyclist identity seems to become a source of conflict.
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Rios, Adyan Beatriz. "Do hurricanes and other severe weather events affect catch per unit effort of reef-fish in the Florida Keys?" Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/32885.
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Severe weather events frequently affect important marine fish stocks and fisheries along the United States Atlantic and Gulf of Mexico coasts. However, the effects of these events on fish and fisheries are not well understood. The availability of self-reported data from two fisheries in a region frequently affected by tropical cyclones provided a unique opportunity to investigate short-term responses to past events. This study involved selecting severe weather events, calculating changes in effort and catch-per-unit- effort (CPUE), and analyzing those changes across various temporal, spatial, and species-specific scenarios. Responses in each variable were analyzed within and across scenario factors and explored for correlations and linear multivariate relationships with hypothesized explanatory variables. A negative overall directional change was identified for logbook fishing effort. Based on both correlations and linear models, changes in logbook fishing effort were inversely related to changes in average maximum wind speed. Severe weather events are more likely to affect fishing effort than catch rates of reef-fish species. However, lack of responses in CPUE may also relate to the ability of this study to detect changes. The temporal and spatial scales analyzed in this study may not have been adequate for identifying changes in effort for the headboat fishery, or in CPUE for either fishery. Although there was no region-wide response in CPUE associated with severe weather events, further research on this topic is necessary to determine if storm-induced changes in fishery data are likely strong, long-lasting, or widespread enough to influence the outcome of stock-wide assessments.Master of Science
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Röjler, Håkan, and Oscar Henriksen. "Vem tjänar på titeln? : En studie om sportsliga framgångar inom cykelsporten påverkar titelsponsorer." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-30403.
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Purpose: The purpose of this study is to examine whether or not a winning performance within professional cycling influences the stock exchange. It looks at the impact a win has on a team’s main sponsor through the effect on said sponsor’s company stock price. Methodology: This study has a positivistic and deductive approach when testing the theory of market efficiency. It uses event study methodology to measure the effect of new information on a company’s stock price. The event period lasts from the last working day before the event to the first working day after the event. The study examined 99 winning performances in the UCI World Tour, from January 1, 2005, to April 30, 2016. Normal return before the event window was calculated from an estimation period of 250 working days. A T-test was used to assess if the results were significant. Results: The study found, based on the complete samples including all cycling races, that there is no significant effect on a main sponsor’s stock price. The Average Abnormal Return came out as 0,04 percent. 46 one day races were examined, resulting in an AAR of -0,1 percent. This means that there was no significant effect on the sponsor’s stock price. For the stage races, on the other hand, the 44 measurements resulted in an AAR of 0,38 percent with a positive 5 percent significance level. Nine measurements derived from the Grand Tours resulted in an AAR of -0,96 percent and a negative 5 percent significance level. Conclusions: The conclusion of this study is that there is no significant effect on the main team sponsor’s stock price, regardless of categorisation. While single day races generated no significant effect, the stage races did have a positive significant effect. Based on the study, The Grand Tour races resulted in a negative effect but the samples for this category were too few to draw a final conclusion from.
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MCKEE, ROBERTA LYNN. "THE DIFFERENTIAL BEHAVIOR OF GLUCAGON AGONISTS AND ANTAGONISTS ON NORMAL AND DIABETIC LIVER: EVIDENCE FOR CYCLIC-AMP - INDEPENDENT EVENTS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184083.
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A nonrecirculatory liver slice perifusion system has been developed and utilized for investigating glucagon-stimulated glycogenolysis in normal and diabetic states. It has been shown here that slices maintained in this system experience a controlled environment with respect to temperature and pH and remain viable throughout a three-hour experimental period based upon their maintenance of intracellular potassium levels. Although glycogen content falls by 40%, slices exhibit significant glycogenolysis in a dose-response manner upon challenge with glucagon, with maximal concentrations eliciting a 2.2-fold stimulation. This system, which permits nonrecirculatory challenge of liver tissue and subsequent analysis of both intracellular events and overall physiological responses, is extremely useful for examining hormonal mechanisms operating for glucagon, particularly at low concentrations. Using this methodology, liver slices challenged with glucagon exhibit a biphasic dose-response for glycogenolysis. While the second phase parallels cAMP (cyclic adenosine 3':5'-monophosphate) accumulation and cAMP-PK (cAMP-dependent protein kinase) activation, the first is mediated independent of cAMP. Trinitrophenylhistidine-1, homoarginine-12-glucagon (THG), which can antagonize glucagon-stimulated adenylate cyclase, exhibits 50% partial agonist activity for cAMP production and cAMP-PK but full agonism for glycogenolysis. Separation between these events is only two-fold indicating a cAMP-mediated process. [Des-amino-fYRKKE]-glucagon, ([Des-amino-His¹,D-Phe⁴,Tyr⁵,Arg¹²,Lys¹⁷·¹⁸,Glu²¹]-glucagon), another adenylate cyclase antagonist, does not stimulate cAMP or cAMP-PK up to 25 μM yet still elicits glycogenolysis. These results demonstrate that glucagon does indeed stimulate both cAMP-independent as well as cAMP-dependent glycogenolysis in normal liver. In diabetic systems, glucagon elicits attenuated adenylate cyclase activity in liver plasma membranes with reduction in basal activity and extent of stimulation. Maximal stimulation of cAMP production is also reduced by half in liver slices, but in both systems (normal vs. diabetic) EC₅₀ values for cAMP production are identical. Neither THG nor [des-amino-fYRKKE]-glucagon stimulate cAMP production or cAMP-PK in diabetic liver slices. While THG lowers blood glucose levels in vivo, [des-amino-fYRKKE]-glucagon acts as an agonist. These results suggest that the mechanisms which operate for glucagon-stimulated glycogenolysis in normal liver are attenuated in the diabetic state. Furthermore, antagonism of cAMP production alone is insufficient to antagonize glucagon's overall physiological action.
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Adams, David. "Modulation of agonist-stimulated second messenger and contractile events in bovine tracheal smooth muscle with cyclic nucleotide PDE inhibitors." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/33624.
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The aim of this thesis was to investigate and characterize the effects of isoenzyme- selective phosphodiesterase (PDE) inhibitors on a range of biochemical and functional parameters in bovine airway smooth muscle in order to further our understanding of 'cross-talk' between different second messenger pathways in this tissue. Cyclic nucleotide levels were measured after selective or non-selective PDE isoenzyme inhibition under conditions of basal and stimulated adenylyl and guanylyl cyclase activity. These data led to the conclusion that PDE IV plays an important role in the regulation of agonist-stimulated increases in cAMP levels, since under conditions of isoprenaline stimulation, incubation with the PDE IV-selective inhibitor rolipram resulted in an increase in cAMP from a control level of 20 2.7 to 50.3 4.0 pmol/mg protein. This response was potentiated in a synergistic manner by simultaneously inhibiting PDE III with ORG 9935. Co-inhibition of PDE III/IV also resulted in a significant increase in basal cAMP levels in tracheal smooth muscle slices and a marked decrease in the rolipram EC50 for cAMP accumulation in isoprenaline-stimulated slices from 205 102 to 7.3 3.0 muM. This suggested that metabolism of cAMP by PDE III is also functionally important in this tissue at least when PDE IV activity is compromized. Evidence was also obtained to suggest that cGMP is metabolized by PDE V, since incubation with zaprinast resulted in a 47% increase in basal cGMP values; however, where cGMP levels were elevated a greater increase in cGMP accumulation was seen in the presence of the nonspecific PDE inhibitor, IBMX (24.3 1.6 pmol/mg protein) compared to that seen with zaprinast (15.2 1.6 pmol/mg protein) suggesting that cGMP metabolism by other PDEs plays a significant role under these conditions. The effects of selective PDE inhibition on agonist-stimulated inositol phosphate accumulation was then investigated. Stimulation with maximally-effective concentrations of carbachol and histamine for 30 min resulted in 36- and 10-fold increases in inositol phosphate accumulations. The response to carbachol (1-100 muM) was largely unaffected by increases in cAMP accumulation caused by isoprenaline or PDE inhibition, however both manipulations inhibited the response to histamine (100muM) by approximately 80%. Again the inhibitory effects of rolipram were potentiated by ORG 9935 such that the EC50 value for rolipram-mediated inhibition was decreased from 120 27 to 1.5 0.9 muM. Such results suggest that PDE III/IV inhibition may be effective in relaxing airway smooth muscle. Consequently it was established that whilst rolipram could inhibit smooth muscle contraction stimulated by histamine or sub-maximal concentrations of methacholine, co-inhibition of PDEs with rolipram and ORG 9935 resulted in a much more potent anti-spasmogenic action. Furthermore, in contrast with the effects of rolipram alone the PDE III/IV inhibitor combination also significantly inhibited phasic contractions generated by either agonist. For example rolipram/ORG 9935 completely abolished the ability of 30uM histamine to cause a phasic contractile response. In common with previous suggestions that the membrane hyperpolarizing actions of cAMP-elevating agents may be responsible, at least in part, for the relaxation of trachealis muscle, experiments reported here suggest that PDE inhibition causes membrane hyperpolarization, possibly through increasing the open-state probability of the high- conductance, calcium-activated potassium channel, and this action may account for the mechanism whereby selective PDE inhibitors can inhibit phosphoinositide turnover and possibly as a consequence relax airway smooth muscle.
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Portugal, Denise Sodero Vinhas. "Modelagem e programação de sistemas a eventos discretos periodicos." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/261069.
Full textAbstract:
Orientador: Rafael Santos MendesTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação
Made available in DSpace on 2018-08-07T23:46:24Z (GMT). No. of bitstreams: 1 Portugal_DeniseSoderoVinhas_D.pdf: 1731980 bytes, checksum: 98f3bdce8b6d0d6e00e2c6c96ba968f7 (MD5) Previous issue date: 2006
Resumo: Uma metodologia para obter um escalonamento cíclico em Sistemas a Eventos Discretos é proposta neste trabalho. Esta metodologia parte de uma rede de Petri que modela minimamente um sistema a eventos discretos funcionando em regime periódico. O método identifica quais são as redes que podem ser tratadas por ele. As redes de Petri tratáveis serão decompostas em subredes identificadas por processos, que são classificados de acordo com suas topologias, o que permite a modelagemdo escalonamento cíclico do sistema através de uma modelagem em programação linear inteira mista. Este modelo em MILP será implementado no software GAMS. Alguns exemplos tirados da literatura serão usados para mostrar e testar a aplicação desta metodologia
Abstract: A methodology to obtain a cyclic scheduling in Discrete Events Systems is proposed in this work. This methodology initializes with a Petri netmodeling a discrete events system functioning with periodic processing. The method identifieswhich are the nets that can be treaties by him. The ¿tractable¿ Petri nets will be decomposed in subnets identified by process, which are classified according to its topologies, that permits us tomodel the cyclic scheduling of the systemby amixed integer linear programming model. This model in MILP will be implemented using software GAMS. Some examples from the literature will be used to show and to test the application of this methodology
Doutorado
Automação Industrial
Doutor em Engenharia Elétrica
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Alacam, Ozge. "Comparison Strategies In Different Types Of Graphs." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611699/index.pdf.
Full textAbstract:
This study aims to investigate the effects of event type (concepts represented by the graph) in graph comprehension with three graph types (line, bar, area) and two graph designs (linear, round) by means of two different task types (trend assessment, discrete comparison). A novel round graph type was designed for that purpose. Five hypotheses were investigated: H1: Graph type affects comparison strategiesH2: Event type affects comparison strategies
H3: Graph design affects comparison strategies
H4: Graph design and event type interact
H5: Task type affects comparison strategies. As a method to collect data on subjects'
graph perception and comprehension, behavioral (recollected values, word preferences in the description task) and eye-tracking data (scan paths, gaze length, number of fixation, fixation duration and number of transitions) were collected. As an outcome of this thesis, while the event type and the task type seemed to affect the graph comprehension, the effect of graph type, the graph design and interaction between graph design and event type were partially observed. These results point out that although round and linear graph designs are informationally equivalent, the round graphs are computationally better suited than linear graphs for the interpretation of cyclic concepts. However, grasping trend information for the linear events and making discrete comparisons were achieved with the same effort in both graph designs. This result is not trivial at all, given the fact that participants were not familiar with the round graph design and were confronted with them in this experiment for the first time.
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Moule, S. K. "Primary events underlying the short-term stimulation of a Na'+'- dependant amino acid transport in hepatocytes by cyclic AMP and EGF : The role of cation transport systems." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233755.
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Vasudevan, Siddarth. "Design and Development of a CubeSat Hardware Architecture with COTS MPSoC using Radiation Mitigation Techniques." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-285577.
Full textAbstract:
CubeSat missions needs components that are tolerant against the radiation in space. The hardware components must be reliable, and it must not compromise the functionality on-board during the mission. At the same time, the cost of hardware and its development should not be high. Hence, this thesis discusses the design and development of a CubeSat architecture using a Commercial Off-The- Shelf (COTS) Multi-Processor System on Chip (MPSoC). The architecture employs an affordable Rad-Hard Micro-Controller Unit as a Supervisor for the MPSoC. Also, it uses several radiation mitigation techniques such as the Latch-up protection circuit to protect it against Single-Event Latch-ups (SELs), Readback scrubbing for Non- Volatile Memories (NVMs) such as NOR Flash and Configuration scrubbing for the FPGA present in the MPSoC to protect it against Single-Event Upset (SEU)s, reliable communication using Cyclic Redundancy Check (CRC) and Space packet protocol. Apart from such functionalities, the Supervisor executes tasks such as Watchdog that monitors the liveliness of the applications running in the MPSoC, data logging, performing Over-The-Air Software/Firmware update. The thesis work implements functionalities such as Communication, Readback memory scrubbing, Configuration scrubbing using SEM-IP, Watchdog, and Software/Firmware update. The execution times of the functionalities are presented for the application done in the Supervisor. As for the Configuration scrubbing that was implemented in Programmable Logic (PL)/FPGA, results of area and latency are reported.CubeSat-uppdrag behöver komponenter som är toleranta mot strålningen i rymden. Maskinvarukomponenterna måste vara pålitliga och funktionaliteten ombord får inte äventyras under uppdraget. Samtidigt bör kostnaden för hårdvara och dess utveckling inte vara hög. Därför diskuterar denna avhandling design och utveckling av en CubeSatarkitektur med hjälp av COTS (eng. Custom-off-The-Shelf) MPSoC (eng. Multi Processor System-on-Chip). Arkitekturen använder en prisvärd strålningshärdad (eng. Rad-Hard) Micro-Controller Unit(MCU) som Övervakare för MPSoC:en och använder också flera tekniker för att begränsa strålningens effekter såsom kretser för att skydda kretsen från s.k. Single Event Latch-Ups (SELs), återläsningsskrubbning för icke-volatila minnen (eng. Non-Volatile Memories) NVMs som NOR Flash och skrubbning av konfigurationsminnet skrubbning för FPGA:er i MPSoC:en för att skydda dem mot Single-Event Upsets (SEUs), och tillhandahålla pålitlig kommunikation mha CRC och Space Packet Protocol. Bortsett från sådana funktioner utför Övervakaren uppgifter som Watchdog för att övervaka att applikationerna som körs i MPSoC:en fortfarande är vid liv, dataloggning, och Over- the-Air-uppdateringar av programvaran/Firmware. Examensarbetet implementerar funktioner såsom kommunikation, återläsningsskrubbning av minnet, konfigurationsminnesskrubbning mha SEM- IP, Watchdog och uppdatering av programvara/firmware. Exekveringstiderna för utförandet av funktionerna presenteras för den applikationen som körs i Övervakaren. När det gäller konfigurationsminnesskrubbningen som implementerats i den programmerbara logiken i FPGA:n, rapporteras area och latens.
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Zhang, Hongchang. "Ordonnancement cyclique robuste appliqué à la gestion des conteneurs dans les ports maritimes de taille moyenne." Thesis, Ecole centrale de Lille, 2014. http://www.theses.fr/2014ECLI0018/document.
Full textAbstract:
Cette thèse présente une méthodologie d’ordonnancement cyclique robuste appliquée à la gestion des conteneurs dans les ports maritimes de taille moyenne. Ces derniers sont sujet constamment à des variations des conditions des terminaux, la visibilité réduite sur des évènements futurs ne permet pas de proposer une planification précise des tâches à accomplir. L’ordonnancement cyclique robuste peut jouer un rôle primordial. Il permettra non seulement de proposer un ordonnancement prédictif pour le transport des conteneurs, mais aussi, il proposera également une planification robuste permettant d’éliminer les perturbations éventuelles en temps réel. Dans ce travail nous utilisons les Véhicules Intelligents Automatisés (AIV) pour transporter les conteneurs et nous modélisons les procédures de transit de ces derniers par des graphes d’évènements P-temporels fortement connexes (PTSCEG). Avant l’arrivée d’un porte conteneur au port, un plan (planning) de transport des conteneurs est proposé en un temps court par la programmation linéaire mixte (MIP). Des algorithmes polynomiaux de calcul de robustesse permettent de calculer sur les différents nœuds du système les marges de robustesse. Une fois le navire à quai, l’ordonnancement cyclique robuste est appliqué. Lorsqu’une perturbation est observée (localisée) dans le système, une comparaison avec la marge de robustesse connue est effectuée. Si cette perturbation est incluse dans la marge de robustesse, l’algorithme robuste est utilisé pour éliminer ces perturbations en quelques cycles. Dans le cas où la perturbation est trop importante, la méthode MIP est utilisée pour calculer un nouvel ordonnancement cyclique en un temps réduitThis PhD thesis is dedicated to propose a robust cyclic scheduling methodology applied to container management of medium sized seaport which faces ever changing terminal conditions and the limited predictability of future events and their timing. The robust cyclic scheduling can be seen not just a predictable scheduling to compute a container transportation schedule, but also a reactive scheduling to eliminate the disturbances in real time. In this work, the automated intelligent vehicles (AIV) are used to transport the containers, and the P-time strongly connected event graph (PTSCEG) is used as a graphical tool to model the container transit procedures. Before the arrival of the container vessel, a cyclic container transit schedule can be given by the mixed integer programming (MIP) method in short time. The robustness margins on the nodes of the system can be computed by robustness algorithms in polynomial computing time. After the stevedoring begins, this robust cyclic schedule is used. When a disturbance is observed in system, it should be compared with the known robustness margin. If the disturbance belongs to the robustness margin, the robustness algorithm is used to eliminate the disturbance in a few cycle times. If not, the MIP method is used to compute a new cyclic schedule in short time
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Orire, Endurance. "The techno-economics of bitumen recovery from oil and tar sands as a complement to oil exploration in Nigeria / E. Orire." Thesis, North-West University, 2009. http://hdl.handle.net/10394/5704.
Full textAbstract:
The Nigeria economy is wholly dependent on revenue from oil. However, bitumen has been discovered in
the country since 1903 and has remained untapped over the years. The need for the country to
complement oil exploration with the huge bitumen deposit cannot be overemphasized. This will help to
improve the country's gross domestic product (GDP) and revenue available to government. Bitumen is
classifled as heavy crude with API (American petroleum Institute) number ranging between 50 and 110
and occurs in Nigeria, Canada, Saudi Arabia, Venezuela etc from which petroleum products could be
derived.
This dissertation looked at the Canadian experience by comparing the oil and tar sand deposit found in Canada with particular reference to Athabasca (Grosmont, Wabiskaw McMurray and Nsiku) with
that in Nigeria with a view of transferring process technology from Canada to Nigeria. The Nigeria and Athabasca tar sands occur in the same type of environment. These are the deltaic, fluvial marine deposit in an incised valley with similar reservoir, chemical and physical properties. However, the Nigeria tar sand is more asphaltenic and also contains more resin and as such will yield more product volume during
hydro cracking albeit more acidic. The differences in the components (viscosity, resin and asphaltenes
contents, sulphur and heavy metal contents) of the tar sands is within the limit of technology adaptation.
Any of the technologies used in Athabasca, Canada is adaptable to Nigeria according to the findings of this research.
The techno-economics of some of the process technologies are. x-rayed using the PTAC (petroleum
technology alliance Canada) technology recovery model in order to obtain their unit cost for Nigeria
bitumen. The unit cost of processed bitumen adopting steam assisted gravity drainage (SAGD), in situ
combustion (ISC) and cyclic steam stimulation (CSS) process technology is 40.59, 25.00 and 44.14
Canadian dollars respectively. The unit cost in Canada using the same process technology is 57.27, 25.00
and 61.33 Canadian dollars respectively. The unit cost in Nigeria is substantively lesser than in Canada.
A trade off is thereafter done using life cycle costing so as to select the best process technology for the
Nigeria oil/tar sands. The net present value/internal rate of return is found to be B$3,062/36.35% for
steam assisted gravity drainage, B$I,570124.51 % for cyclic steam stimulation and B$3,503/39.64% for in
situ combustion. Though in situ combustion returned the highest net present value and internal rate of
return, it proved not to be the best option for Nigeria due to environmental concern and response time to
production. The best viable option for the Nigeria tar sand was then deemed to be steam assisted gravity
drainage.
An integrated oil strategy coupled with cogeneration using MSAR was also seen to considerably amplify
the benefits accruable from bitumen exploration; therefore, an investment in bitumen exploration in
Nigeria is a wise economic decision.Thesis (M.Ing. (Development and Management))--North-West University, Potchefstroom Campus, 2010.
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Li, Xinxin. "Organic Carbon Cycling in East China Sea Shelf Sediments: Linkages with Hypoxia." Thesis, 2013. http://hdl.handle.net/1969.1/149240.
Full textAbstract:
The Changjiang River provides the main source of sediment and terrestrial derived organic carbon (OC) to the Changjiang large delta-front estuary (LDE) in the East China Sea (ECS). This study analyzed bulk OC, biomarkers including lignin and plant pigment, black carbon (BC) on ECS sediments sampled in winter 2009 and 2010 in order to study the OC cycling under the influence of natural and anthropogenic disturbance. Low-oxygen tolerant foraminiferal microfossils were analyzed in another two sediment cores to study the historical hypoxia events in the Changjiang LDE.
Bulk carbon to nitrogen (C/N) ratio and stable isotope δ13C in the surface sediment samples indicated a mixture source of terrestrial, deltaic and marine derived OC. Refractory BC and reworked marine OC seemed to comprise most of the OC pool with older, less reactive signatures as deduced from ∆14C, and BC analyses. Winter wind/wave energy and hydrodynamic sorting had a substantial winnowing effect on surface sediment OC redistribution. As a result, the highest lignin concentration shifted to the south during the 2010 cruise after the summer flood event. In addition, algal inputs from local deltaic lakes due to eutrophication and/or lateral transport likely caused the observed lack of benthic-pelagic coupling of pigment concentrations between the surface sediments and the water column after the summer flood in 2010.
For the down-core sediment, the mass accumulation rate distribution followed the dispersal pathway of the ECS sediment. Terrestrial and marine derived OC showed significant spatial and temporal distribution. Lignin rich materials were better preserved in sediments closer to the coast while offshore sediments tended to be composed of lignin-poor, degraded OC, that were likely hydrodynamically sorted to a long distance during transport. Besides eutrophication, plant pigments indicated that marine-derived OC was mostly deposited in the sediment mixed layer with decay in the underlying sediment accumulation layer. The total OC standing stock since 1900 is approximately 1.62±1.15 kgC m^-2, about 1/10 of the total OC stock in all the middle and lower lakes in the Changjiang catchment.
There has been an increase in the number of hypoxic bottom water events on the Changjiang LDE over the past 60 yrs indicated from the increases in low-oxygen tolerant foraminiferal microfossils due to excess deposition of OC and summer stratification.
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Suchánek, Jiří. "Management závodu Author Král Šumavy MTB." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-448346.
Full textAbstract:
Name: Management of the Author Král Šumavy MTB Race Goal: Presentation of strengths and weaknesses of the Author Král Šumavy MTB 2020 cycling race and the creation of a list of specific measures improving the organisation of the race for the year 2021 and following. Methods: In this thesis three research methods (semi-structured interview, participant observation, questionnaire), and one analytical method (SWOT analysis), are used. The opinions of the race participants weree obtained with an eletronic questionnaire (sent to emails of all participants in 2020). The organizers'view of the race management is clarified through semi-structured interviews. The overall view of the management was observed through participant observation made by two independent researchers on the day of the race (August 22, 2020) at the venue. All obtained data are analysed through SWOT analysis. Results: The thesis provides a detailed analysis of the 27th year of the race. The results show that the strengths include the location of the race, the difficulty of the routes and the care of participants. The weakness is the current way of financing the race. It can be stated that the greatest opportunities for the future are creating a better area for participants and spectators, gaining new partners and improving promotion....
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Hui-Yu, Li, and 李惠玉. "Determining the Elements of Event Planning in Cycling Race." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/75909594405516581856.
Full textAbstract:
碩士大葉大學
運動健康管理學系
103
In this thesis, we aim to understand the acceptance level of elements of event planning in cycling race from the participants. The materials were the people who participated in cycling race which held by Taiwan Bike Association in July to September, 2014. We categorize the elements of event planning in cycling race by Kano model, analyze the quality improvement index according to customer satisfaction coefficient, and represent the elements distribution by satisfaction index scatter diagram. The research is regarded to provide the organizers a reference to event planning to improve the priorities. We found two results of this research. First, the elements of event planning in cycling race in Kano model produce different categorization of the elements, instead of one dimension. Second, it should prioritize the following items: “restrictive intersections with traffic controller”, “warning signs at major intersections or curves”, “program planning satisfied safety”, “setting enough rest areas, medical stations and staffs” and “planning parking spaces and toilets completely”. To increase the participants satisfaction significantly, “publishing grades quickly and researching conveniently” should be highlighted instead of “practicability of sponsored commodity” and “supply souvenir metals for finishing event”. On the other hand, the organizer should maintain the quality for “preparation for substitute of encountering natural disasters”, “detailed official program”, “supply shuttle service when event occurring some troubles” and “supply meals and souvenir for finishing event” in order to reduce the participants dissatisfaction.Key Words: event planning in cycling race, Kano model , customer satisfaction coefficient
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Chang, Yu-Yuan, and 張有元. "Large-Scale Environment Analysis and Prediction of Tropical Cyclone Rapid Intensification Events." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7wc4r9.
Full textAbstract:
碩士淡江大學
水資源及環境工程學系碩士班
106
Rapid intensification (RI) is one of the most challenging issues for operational tropical cyclone (TC) forecasting. According to the National Hurricane Center, a RI event is defined as an increase in the maximum sustained wind speed by at least 30 kt within a 24-h period. The 24-h TC intensity forecast errors are significantly larger during the rapid intensification stage. In this study, various datasets are utilized to investigate the RI events of the western North Pacific TCs. The SHIPS (Statistical Hurricane Intensity Prediction Scheme) Developmental Dataset is used to explore the characteristics of the RI and non-RI events. Recent studies show that the RI events are related to not only the upper ocean thermal structure but also the density and salinity structure. Thus the HYCOM (Hybrid Coordinate Ocean Model) ocean analysis is also used to study the impact of the pre-existing ocean conditions on TC development and intensification. Finally,probabilistic forecast models for the prediction of RI events are developed by using the Quantile Regression(QR) and Logistic Regression(LR) methods. Results show that the QR model that includes the SHIPS predictors and the ETCHP (Effective TC Heat Potential) has the best performance. The area under ROC curve (AUC) of the QR model is 0.88. The probability of detection (POD) is 94%, which is 10% better than for the best LR model. In addition, the false alarm ratio (FAR) is 10% lower. Thus, the QR model can provide more skillful probability forecasts of TC RI events.
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Lai, Cheng Chou, and 賴政州. "Virtual Reality Dual-task Cognitive-cycling Task Design and Cerebral Event-related Dynamics Investigation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/t98hm3.
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Wang, Yuan-Ming, and 王元明. "Exploring the Effect of Self-Efficacy on Primary School Graduates:A Long-Distance Cycling Event." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/45091882505011627921.
Full textAbstract:
碩士樹德科技大學
經營管理研究所
102
This study explored the effects on self-efficacy of primary school graduates after their participation of a long-distance cycling event. Two focus group interviews conducted. Twelve primary school graduates selected for interviews with six in each interview. The contextual data were classified and analyzed. Results showed this long-distance cycling event affects the graduates’ self-efficacy. This efficacy was getting stronger once the graduates decided to ride for this event. This effect dramatically found stronger by the end of this event. This process of self-efficacy can become a model for the students’ future life skills learning or problem solving. Research implications and future research directions were provided.
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Simmons, Kovacs Laura Anne. "Defining Roles for Cyclin Dependent Kinases and a Transcriptional Oscillator in the Organization of Cell-Cycle Events." Diss., 2009. http://hdl.handle.net/10161/1611.
Full textAbstract:
The cell cycle is a series of ordered events that culminates in a single cell dividing into two daughter cells. These events must be properly coordinated to ensure the faithful passage of genetic material. How cell cycle events are carried out accurately remains a fundamental question in cell biology. In this dissertation, I investigate mechanisms orchestrating cell-cycle events in the yeast,
Cyclin dependent kinase (CDK) activity is thought to both form the fundamental cell-cycle oscillator and act as an effector of that oscillator, regulating cell-cycle events. By measuring transcript dynamics over time in cells lacking all CDK activity, I show that transcriptional oscillations are not dependent on CDK activity. This data indicates that CDKs do not form the underlying cell-cycle oscillator. I propose a model in which a transcription factor network rather than CDK activity forms the cell-cycle oscillator. In this model, CDKs are activated by the periodic transcription of cyclin genes and feedback on the network increasing the robustness of network oscillations in addition to regulating cell-cycle events.
I also investigate CDK-dependent and -independent mechanism regulating the duplication of the yeast centrosome, the spindle pole body (SPB). It is critical for the formation of a bipolar spindle in mitosis that the SPB duplicates once and only once per cell cycle. Through a combination of genetic and microscopic techniques I show that three distinct mechanisms regulate SPB duplication, ensuring its restriction to once per cell cycle.
Together, the data presented in this dissertation support a model in which CDKs, periodic transcription, and a TF-network oscillator are all important cell-cycle regulatory mechanisms that collaborate to regulate the intricate collection of events that constitute the cell cycle.
Dissertation
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Aguiar, Afonso, Miguel Moreira Tavares, Maria de Freitas Carneiro Pedroso, and Neuza Marcelo Marques Nunes. "The economic impact of the event Volta a Portugal em Bicicleta 2015." Master's thesis, 2016. http://hdl.handle.net/10362/16518.
Full textAbstract:
This thesis is a Field Lab project requested by the organizer of the Volta a Portugal
em Bicicleta 2015, Podium Events. Its purpose is to determine the economic impact of the
event for the 21 host economies and Portugal as a whole. The Volta started in Viseu and ended
in Lisboa, and lasted for two weeks from the 29th July until the 8th August. Results were
computed by accessing data provided by the different economic agents involved in the event
(spectators, attendees and organizer), through face-to-face surveys and contact via e-mail. The
Volta generated a total economic impact of €76.261.876.
Keywords: Cycling,
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Abdi, Ahmad. "The Cycling Property for the Clutter of Odd st-Walks." Thesis, 2014. http://hdl.handle.net/10012/8194.
Full textAbstract:
A binary clutter is cycling if its packing and covering linear program have integral optimal solutions for all Eulerian edge capacities. We prove that the clutter of odd st- walks of a signed graph is cycling if and only if it does not contain as a minor the clutter of odd circuits of K5 nor the clutter of lines of the Fano matroid. Corollaries of this result include, of many, the characterization for weakly bipartite signed graphs, packing two- commodity paths, packing T-joins with small |T|, a new result on covering odd circuits of a signed graph, as well as a new result on covering odd circuits and odd T-joins of a signed graft.
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LIU, YU-CHEN, and 劉雨禎. "The Relationship between Event Marketing of Cycling around The Island and Corporate Image –A Case Study of E.SUN BANK." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/pwwagf.
Full textAbstract:
碩士國立高雄第一科技大學
運籌管理系企業管理碩士專班
105
To explore the relationship between the marketing event of cycling around Taiwan and corporate image, the research takes the event named “Cycling around Taiwan, Conveying Love in thousand miles”held by E.Sun Bank as an example. Through communications addressed in related literature, taking general customers as the subject, adopting procedures of experimental method, the event is divided into 3 types. They are “Cycling around Taiwan for spontanuous customers”, “Cycling around Taiwan for those who recieved sponsorship”and “Cycling around Taiwan for those who recuited by sponsored ones.”Analyze the experiment in 3 types supplemented with narrative statistics, ANOVA variance analysis methods, etc., to discuss the relationship among “the types of marketing event”, “attitudes for cyclers of this event”and “corporate image.” The result shows the event held by E.Sun bank did positive effect on its corporate image. However, different types led to different outcomes. The beneficial result from “Cycling around Taiwan for spontanuous customers”is better than that from “Cycling around Taiwan for those who recived sponsorship.”That means this marketing event about sports is worth taking as reference for corporate marketing. About types of sponsored ones, compared “Cycling around Taiwan for those who recived sponsorship”and “Cycling around Taiwan for those who recuited by sponsored ones,”there is no obvious difference on corporate image. However, the latter type has bit better beneficial effect. Thus the researcher advises the corporate can consider the type of “Cycling around Taiwan for spontanuous customers”and widely invite customers or the public to participate. This may expand the event scale and influence and then form a better corporate image. About the attitude for cyclers of this event, the result shows cycling around Taiwan for general customers of E.Sun Bank is a positive and meaningful sport activity, and widely accepted and recoginized. Though the data presents there is a remarkable relationship with corporate image respectively on the type of cycling around Taiwan and the attitude for cyclers of this activity, there is no significant interaction effect with corporate image for both of them.
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Mabry, James Brice. "The impact of glaciation and climate change on biogeochemical cycling and landscape development." Thesis, 2012. http://hdl.handle.net/1805/2761.
Full textAbstract:
Indiana University-Purdue University Indianapolis (IUPUI)Lake cores from Dry Lake, California and Crystal Lake, Illinois were analyzed to identify climate variability and characterize landscape response to glacial/deglacial climate transitions. Geochemical analysis of the Dry Lake sediment prior to the 8.2 kyr event revealed average values for percent total organic carbon to be 4% with a range of 0.2% to 15.2%. The average decreased to approximately 2.1% with a range of 0.4% to 5.3% during and after the event. Occluded phosphorus averaged 488 µg/g before the 8.2 kyr event and 547 µg/g after but was much lower during the event at 287 µg/g. These results were interpreted as an environment which began as warm, wet, and productive then quickly turned colder and drier during the 8.2 kyr event which resulted in a resetting of soil development. The higher temperatures returned after the 8.2 kyr event which allowed for continued soil development despite its drier climate. Previous research corroborated these conclusions. The Crystal Lake geochemical record was very different from Dry Lake. Percent total organic carbon averaged 6.7% with a range of 3.9% to 8.5% during the Younger Dryas but recorded a lower average before and after at 4.9% and 4.6% respectively. Occluded phosphorus acted similarly with a higher average during the cooling event, 2626 µg/g, and lower averages before and after, 1404 µg/g and 1461 µg/g, respectively. This was interpreted as continued productivity and soil development through the cold period which was attributed to a change in biomass.
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Phillips, George Douglas. "Northern hemisphere winter season extratropical cyclone activity following the onset of an El Niño event." 1987. http://catalog.hathitrust.org/api/volumes/oclc/17436899.html.
Full textAbstract:
Thesis (M.S.)--University of Wisconsin--Madison, 1987.Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 83-85).