Academic literature on the topic 'Cyclic dinucleotides'
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Journal articles on the topic "Cyclic dinucleotides"
Foley, J. F. "Cyclic Dinucleotides Get Stung." Science Signaling 4, no. 197 (November 1, 2011): ec303-ec303. http://dx.doi.org/10.1126/scisignal.4197ec303.
Full textLuteijn, Rutger D., Shivam A. Zaver, Benjamin G. Gowen, Stacia K. Wyman, Nick E. Garelis, Liberty Onia, Sarah M. McWhirter, et al. "SLC19A1 transports immunoreactive cyclic dinucleotides." Nature 573, no. 7774 (September 11, 2019): 434–38. http://dx.doi.org/10.1038/s41586-019-1553-0.
Full textGuey, Baptiste, and Andrea Ablasser. "A carrier for cyclic dinucleotides." Nature Immunology 20, no. 11 (October 10, 2019): 1418–20. http://dx.doi.org/10.1038/s41590-019-0521-z.
Full textMaelfait, Jonathan, and Jan Rehwinkel. "RECONsidering Sensing of Cyclic Dinucleotides." Immunity 46, no. 3 (March 2017): 337–39. http://dx.doi.org/10.1016/j.immuni.2017.03.005.
Full textTschowri, Natalia. "Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species." Journal of Bacteriology 198, no. 1 (July 27, 2015): 47–54. http://dx.doi.org/10.1128/jb.00423-15.
Full textTosolini, Marie, Frédéric Pont, Delphine Bétous, Emmanuel Ravet, Laetitia Ligat, Frédéric Lopez, Mary Poupot, et al. "Human Monocyte Recognition of Adenosine-Based Cyclic Dinucleotides Unveils the A2a GαsProtein-Coupled Receptor Tonic Inhibition of Mitochondrially Induced Cell Death." Molecular and Cellular Biology 35, no. 2 (November 10, 2014): 479–95. http://dx.doi.org/10.1128/mcb.01204-14.
Full textLópez-Villamizar, Iralis, Alicia Cabezas, Rosa María Pinto, José Canales, João Meireles Ribeiro, Joaquim Rui Rodrigues, María Jesús Costas, and José Carlos Cameselle. "Molecular Dissection of Escherichia coli CpdB: Roles of the N Domain in Catalysis and Phosphate Inhibition, and of the C Domain in Substrate Specificity and Adenosine Inhibition." International Journal of Molecular Sciences 22, no. 4 (February 17, 2021): 1977. http://dx.doi.org/10.3390/ijms22041977.
Full textLuteijn, Rutger D., Shivam A. Zaver, Benjamin G. Gowen, Stacia K. Wyman, Nick E. Garelis, Liberty Onia, Sarah M. McWhirter, et al. "Author Correction: SLC19A1 transports immunoreactive cyclic dinucleotides." Nature 579, no. 7800 (March 2020): E12. http://dx.doi.org/10.1038/s41586-020-2064-8.
Full textDanilchanka, Olga, and John J. Mekalanos. "Cyclic Dinucleotides and the Innate Immune Response." Cell 154, no. 5 (August 2013): 962–70. http://dx.doi.org/10.1016/j.cell.2013.08.014.
Full textGutten, Ondrej, Petr Jurečka, Zahra Aliakbar Tehrani, Miloš Buděšínský, Jan Řezáč, and Lubomír Rulíšek. "Conformational energies and equilibria of cyclic dinucleotides in vacuo and in solution: computational chemistry vs. NMR experiments." Physical Chemistry Chemical Physics 23, no. 12 (2021): 7280–94. http://dx.doi.org/10.1039/d0cp05993e.
Full textDissertations / Theses on the topic "Cyclic dinucleotides"
Smith, E. E. "Novel dinucleotides, precursors to fluorescent cyclic nucleotides." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487327.
Full textSmyth, Lisa M. "The nicotinamide adenine dinucleotide (NAD)/cyclic ADP-ribose/ADP-ribose system, new to the peripheral synapse." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3210943.
Full textCollins, Thomas Peter. "Regulation of atrial myocyte calcium signalling by second messengers including cyclic AMP, Inositol trisphosphate and nicotinic acid adenine dinucleotide phosphate." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510944.
Full textNoriega, Esteban Núria. "The Rtg1 and Rtg3 proteins are novel transcription factors regulated by the yeast hog1 mapk upon osmotic stress." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7158.
Full textIn Saccharomyces cerevisiae the adaptation to high osmolarity is mediated by the HOG (high-osmolarity glycerol) pathway, which elicits different cellular responses required for cell survival upon osmostress. Regulation of gene expression is a major adaptative response required for cell survival in response to osmotic stress. At least five transcription factors have been reported to be controlled by the Hog1 MAPK. However, they cannot account for the regulation of all of the genes under the control of the Hog1 MAPK. Here we show that the Rtg1/3 transcriptional complex regulates the expression of specific genes upon osmostress in a Hog1-dependent manner. Hog1 phosphorylates both Rtg1 and Rtg3 proteins. However, none of these phosphorylations are essential for the transcriptional regulation upon osmostress. Here we also show that the deletion of RTG proteins leads to osmosensitivity at high osmolarity, suggesting that the RTG-pathway integrity is essential for cell survival upon stress.
Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.
Full textTambé hem observat que la mort cel·lular causada per l'activació sostinguda de Hog1 és deguda a una inducció d'apoptosi. L'apoptosi induïda per Hog1 és inhibida per la mutació al complexe SCFCDC4. Per tant, la via d'extensió de la vida és capaç de prevenir l'apoptosi a través d'un mecanisme desconegut.
Sustained Hog1 activation leads to an inhibition of cell growth. In this work, we have observed that the lethal phenotype caused by sustained Hog1 activation is prevented by SCFCDC4 mutants. The prevention of Hog1-induced cell death by SCFCDC4 mutation depends on the lifespan extension pathway. Upon sustained Hog1 activation, SCFCDC4 mutation increases Msn2 and Msn4 dependent gene expression that leads to a PNC1 overexpression and a Sir2 deacetylase hyperactivation. Then, hyperactivation of Sir2 is able to prevent cell death caused by sustained Hog1 activation.
We have also observed that cell death upon sustained Hog1 activation is due to an induction of apoptosis. The apoptosis induced by Hog1 is decreased by SCFCDC4 mutation. Therefore, lifespan extension pathway is able to prevent apoptosis by an unknown mechanism.
Book chapters on the topic "Cyclic dinucleotides"
Orr, Mona W., and Vincent T. Lee. "Enzymatic Degradation of Linear Dinucleotide Intermediates of Cyclic Dinucleotides." In Microbial Cyclic Di-Nucleotide Signaling, 93–104. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33308-9_6.
Full textDu, Xiao-Xia, and Xiao-Dong Su. "Detection of Cyclic Dinucleotides by STING." In c-di-GMP Signaling, 59–69. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7240-1_6.
Full textMankan, Arun K., Martina Müller, Gregor Witte, and Veit Hornung. "Cyclic Dinucleotides in the Scope of the Mammalian Immune System." In Non-canonical Cyclic Nucleotides, 269–89. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/164_2016_5002.
Full textBurhenne, Heike, and Volkhard Kaever. "Quantification of Cyclic Dinucleotides by Reversed-Phase LC-MS/MS." In Cyclic Nucleotide Signaling in Plants, 27–37. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-441-8_3.
Full textPetchiappan, Anushya, Avisek Mahapa, and Dipankar Chatterji. "Cyclic Dinucleotide Signaling in Mycobacteria." In Microbial Cyclic Di-Nucleotide Signaling, 3–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33308-9_1.
Full textLee, Vincent T. "Detection of Cyclic Dinucleotide Binding Proteins." In Microbial Cyclic Di-Nucleotide Signaling, 107–24. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33308-9_7.
Full textSintim, Herman O., and Clement Opoku-Temeng. "Targeting Cyclic Dinucleotide Signaling with Small Molecules." In Microbial Cyclic Di-Nucleotide Signaling, 577–91. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33308-9_33.
Full textSchwede, Frank, Hans-Gottfried Genieser, and Andreas Rentsch. "The Chemistry of the Noncanonical Cyclic Dinucleotide 2′3′-cGAMP and Its Analogs." In Non-canonical Cyclic Nucleotides, 359–84. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/164_2015_43.
Full textGraeff, Richard M., and Hon Cheung Lee. "Determination of ADP-Ribosyl Cyclase Activity, Cyclic ADP-Ribose, and Nicotinic Acid Adenine Dinucleotide Phosphate in Tissue Extracts." In Cyclic Nucleotide Signaling in Plants, 39–56. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-441-8_4.
Full textMaddess, Matthew, John McIntosh, and Wonsuk Chang. "Discovery and Chemical Development of Uvelostinag (MK-1454): A Therapeutic Cyclic Dinucleotide Agonist of the Stimulator of Interferon Gene." In ACS Symposium Series, 1–94. Washington, DC: American Chemical Society, 2022. http://dx.doi.org/10.1021/bk-2022-1423.ch001.
Full textConference papers on the topic "Cyclic dinucleotides"
Glickman, Laura Hix, David B. Kanne, Kelsey E. Gauthier, George E. Katibah, Justin J. Leong, Ken Metchette, Thomas W. Dubensky, and Sarah M. McWhirter. "Abstract 4272: Potentin situcancer immunotherapy with synthetic human STING-activating cyclic dinucleotides." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4272.
Full textFu, Juan, Qi Zhen, Drew Pardoll, Tom Dubensky, and Young Kim. "Abstract B42: Cyclic dinucleotides (CDNs) activated DC and NK cells in antitumor immunotherapy." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-b42.
Full textDubensky, Thomas W., Meredith L. Leong, David B. Kanne, Edward E. Lemmens, Ken Metchette, Weiqun Liu, Marcella Fasso, et al. "Abstract 4573: STINGVAX - A novel tumor vaccine with cyclic dinucleotides - can induce potent anti-tumor responsesin vivo." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4573.
Full textGadkaree, Shekhar K., Rupashree Sen, Juan Fu, Clint Allen, and Young J. Kim. "Abstract B087: Cyclic dinucleotide: A novel adjuvant for squamous cell carcinoma." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-b087.
Full textGlickman, Laura Hix, Leticia Corrales, Sarah M. McWhirter, David B. Kanne, Kelsey E. Sivick, Jason R. Baird, Edward Lemmens, et al. "Abstract IA10: Effective immunotherapy regimens incorporating highly active human STING-activating cyclic dinucleotide derivatives." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-ia10.
Full textGremel, Gabriela, Maria A. Impagnatiello, Sebastian Carotta, Otmar Schaaf, Paolo M. Chetta, Thorsten Oost, Thomas Zichner, et al. "Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4522.
Full textGlickman, Laura Hix, David B. Kanne, Sarah M. McWhirter, Meredith L. Leong, Edward E. Lemmens, Ken Metchette, Russell E. Vance, Drew M. Pardoll, and Thomas W. Dubensky. "Abstract 2566: Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2566.
Full textMcWhirter, Sarah M., Laura Hix Glickman, Tony Desbien, Kelsey Sivick Gauthier, David Kanne, Shailaja Kasibhatla, Jie Li, et al. "Abstract B020: STING activation in the tumor microenvironment using a synthetic human STING-activating cyclic dinucleotide induces potent antitumor immunity." In Abstracts: Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 25-28, 2016; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6066.imm2016-b020.
Full textWang, Zezhou, Peter Dove, David Rosa, Bolette Bossen, Simone Helke, Marilyse Charbonneau, Laura Brinen, et al. "Abstract 3854: Preclinical characterization of a novel non-cyclic dinucleotide small molecule STING agonist with potent antitumor activity in mice." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3854.
Full textWang, Zezhou, Peter Dove, David Rosa, Bolette Bossen, Simone Helke, Marilyse Charbonneau, Laura Brinen, et al. "Abstract 3854: Preclinical characterization of a novel non-cyclic dinucleotide small molecule STING agonist with potent antitumor activity in mice." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3854.
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