Relevant bibliographies by topics / Cutaneous carcinoma

Academic literature on the topic 'Cutaneous carcinoma'

Author: Grafiati
Published: 8 June 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "Cutaneous carcinoma":

1

Puri, Neerja, Sukhmani Kaur Brar, and B. K. Brar. "A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India." Our Dermatology Online 12, no. 2 (April 1, 2021): 140–44. http://dx.doi.org/10.7241/ourd.20212.7.

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Introduction: Cutaneous metastases may precede a malignancy and, in other cases, herald the recurrence of a malignancy after surgery. Aim: To determine the significance of cutaneous manifestations in patients with an internal malignancy and to observe the various types of carcinomas in patients attending a dermatology OPD. Methods: This was a prospective hospital-based study undertaken to observe the cutaneous features in a dermatology OPD in patients coming from the oncology department of a medical college. Results: The commonest malignancy in males was a lung carcinoma, observed in 5.50% of the patients, followed by a prostate carcinoma, observed in 4.58% of the patients, an esophagus carcinoma, observed in 4.12% of the patients, and a penis carcinoma, observed in 2.29% of the patients. Specific cutaneous manifestations included cutaneous metastatic infiltrates, observed in 5.04% of the patients, and carcinoma erysipeloides, observed in 1.37% of the patients. Discussion: Skin metastases may herald the recurrence of a malignancy after treatment and usually indicate a poor prognosis.
2

Onak Kandemir, Nilufer, Figen Barut, Kıvanç Yılmaz, Husnu Tokgoz, Mubin Hosnuter, and Sukru Oguz Ozdamar. "Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report." Case Reports in Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/913734.

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Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis.
3

Novice, Taylor Shea, David Oberlin, and Chauncey McHargue. "A case of cutaneous metastatic adenosquamous carcinoma of the cervix." SKIN The Journal of Cutaneous Medicine 3, no. 4 (July 8, 2019): 271–74. http://dx.doi.org/10.25251/skin.3.4.7.

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Introduction:Cutaneous metastasis of cervical carcinoma is very rare, with a reported incidence of .1 to 2%. The adenosquamous carcinoma subtype has been reported the least.3-5 We present a case report of ulceronodular cutaneous metastasis of adenosquamous carcinoma of the cervix.Case Description:A 50-year-old African American female with an eleven-year history of metastatic adenosquamous carcinoma of the cervix presented to the emergency department with an asymptomatic rash in her groin for one-month duration. On physical exam, there were hyperpigmented to violaceous papulonodules across the mons pubis and three ulcerated plaques of the left mons pubis. Punch biopsy was consistent with metastases of cervical adenosquamous carcinoma. No disease specific interventions were taken, and the patient passed away five weeks later.Discussion:Cervical cancer rarely metastasizes to the skin, with a reported incidence of .1 to 2%. Among the subtypes, cutaneous metastasis of cervical adenosquamous carcinoma has been reported the least. In a review of 1185 cases of cervical cancer, Imachi et al found that only 15 cases spread cutaneously, none of which were adenosquamous carcinoma.5 Cutaneous metastases of cervical carcinoma predict a poor prognosis, with an average length of survival of three months.6Our patient developed cutaneous metastases eleven years after diagnosis, which is to our knowledge the longest reported interval from initial diagnosis to development of cutaneous metastases. Although rare, it is important to recognize cutaneous metastases of adenosquamous carcinoma of the cervix as it predicts a poor prognosis and treatment has not been shown to improve outcomes.
4

Binsheikhan, S., S. Mittal, and M. Al Abadie. "Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) in Children." European Journal of Medical and Health Sciences 3, no. 5 (September 30, 2021): 15–17. http://dx.doi.org/10.24018/ejmed.2021.3.5.888.

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Introduction: Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder characterised by development of multiple basal cell carcinomas (BCC) at a young age. Case report: A 7 year female child presented with MULTIPLE skin growths on the neck, face and upper chest for 3 years, with prominent forehead and mild non-scarring alopecia. She also had a history of medulloblastoma treated 3 years ago. There was no significant family history. Biopsy from one of the lesions showed basal cell carcinoma (BCC). Discussion: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder caused by mutations in the tumour suppressor patched 1 (PTCH-1) gene. Patients present with both cutaneous and extra-cutaneous manifestations. Multiple basal cell carcinomas (BCCs) are one of the most frequent cutaneous manifestations, occurring on both photo-exposed and non-exposed areas. The commonest extra-cutaneous tumours are medulloblastomas, which are often the first presentation of the disease. There are multiple but no established treatment modalities for the disease.
5

Binsheikhan, S., S. Mittal, and M. Al Abadie. "Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) in Children." European Journal of Medical and Health Sciences 3, no. 5 (September 30, 2021): 15–17. http://dx.doi.org/10.24018/ejmed.2021.3.5.888.

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Introduction: Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder characterised by development of multiple basal cell carcinomas (BCC) at a young age. Case report: A 7 year female child presented with MULTIPLE skin growths on the neck, face and upper chest for 3 years, with prominent forehead and mild non-scarring alopecia. She also had a history of medulloblastoma treated 3 years ago. There was no significant family history. Biopsy from one of the lesions showed basal cell carcinoma (BCC). Discussion: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder caused by mutations in the tumour suppressor patched 1 (PTCH-1) gene. Patients present with both cutaneous and extra-cutaneous manifestations. Multiple basal cell carcinomas (BCCs) are one of the most frequent cutaneous manifestations, occurring on both photo-exposed and non-exposed areas. The commonest extra-cutaneous tumours are medulloblastomas, which are often the first presentation of the disease. There are multiple but no established treatment modalities for the disease.
6

Moreno de Oliveira Fernandes, Tânia Rita, Ricardo Santana de Lima, Ana Kívia Silva Matias, Leonardo Pereira de Souza Alves, and Marcus Vinícius Solano Ferreira de Souza. "Cutaneous Metastasis as the Presenting Sign of Urothelial Carcinoma." Journal of the Portuguese Society of Dermatology and Venereology 78, no. 3 (September 27, 2020): 255–59. http://dx.doi.org/10.29021/spdv.78.3.1203.

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Cutaneous metastases of visceral neoplasms are rare conditions, and urothelial or transitional cell carcinomas are responsible for less than 1% of cases. We report the case of a 50-year-old male patient who progressively developed multiple cutaneous nodules on his head, abdomen, axilla, and groin, some with ulceration. Skin biopsy and immunohistochemistry were consistent with cutaneous metastasis of urothelial carcinoma. Computed tomography scan revealed generalized metastasis in internal organs. In this rare case, cutaneous metastases were the presenting sign of the disease and, as reported, a sign of bad prognosis.
7

Vandeweyer, Eric, François Sales, and Rika Deraemaecker. "Cutaneous verrucous carcinoma." British Journal of Plastic Surgery 54, no. 2 (March 2001): 168–70. http://dx.doi.org/10.1054/bjps.2000.3440.

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8

Pleat, Jonathon, Lisa Sacks, and Howard Rigby. "Cutaneous verrucous carcinoma." British Journal of Plastic Surgery 54, no. 6 (September 2001): 554–55. http://dx.doi.org/10.1054/bjps.2001.3639.

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9

Pazzini, Renato, Gustavo A. Pereira, and Ricardo S. Macarenco. "Cutaneous Metaplastic Carcinoma." American Journal of Dermatopathology 40, no. 7 (July 2018): e100-e103. http://dx.doi.org/10.1097/dad.0000000000001070.

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10

Asuquo, Maurice E., Mark S. Umoh, and Ekpo E. Bassey. "Cutaneous Metastatic Carcinoma." Advances in Skin & Wound Care 23, no. 2 (February 2010): 77–80. http://dx.doi.org/10.1097/01.asw.0000363504.92360.5f.

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Journal articles Dissertations / Theses

Dissertations / Theses on the topic "Cutaneous carcinoma":

1

Lambert, Sally Ruth. "Molecular profiling of cutaneous squamous cell carcinoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/564.

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Cutaneous squamous cell carcinoma (cSCC) is the second most common form of non-melanoma skin cancer and accounts for the majority of deaths from this disease. Its incidence is increasing rapidly, contributing significant morbidity to patients and a burden on healthcare resources. The molecular events underlying cSCC development remain largely uncharacterised, despite the well established role of ultraviolet radiation as a principal carcinogen. Genomewide analyses of the genetic changes underlying cSCC development have shown they are subject to large chromosomal aberrations, which often involve whole chromosome arms. Many of these events occur in a high proportion of tumours, yet the genes they target are unknown. In this study, genomewide expression microarray data has been obtained from a series of cSCC and integrated with single nucleotide polymorphism (SNP) microarray data, to provide a comprehensive analysis of the events associated with tumour development. In total, 222 genes were identified as differentially expressed in cSCC, of which, 21% were concordant with copy number changes. Previous genomewide SNP data of cSCC had identified microdeletions within the PTPRD gene in a subset of tumours (Purdie et al., 2009). This was investigated in further detail and revealed microdeletions in this gene were significantly associated with metastatic cSCC. Sequencing analysis showed 37% of cSCC had a mutation at this locus, which suggests PTPRD is aberrant in a significant proportion of tumours. Decreased expression levels of PTPRD were correspondingly found in moderately and poorly differentiated tumours. The role of PTPRD in skin biology is not known and further functional work is required to elucidate its role in skin cancer. Taken together, these data provide a valuable insight into the genetic background against which cSCC develop. Furthermore, the association of PTPRD disruption with aggressive tumours may potentially be of future benefit as a prognostic biomarker and therapeutic target.
2

Robinson, Kim. "Identification of novel molecular targets for cutaneous squamous cell carcinoma." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/78349252-d233-40ad-9724-7b186baf531b.

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Cutaneous Squamous Cell Carcinoma (cSCC) is the most common human tumour with malignant potential which is responsible for over 1 in 4 skin cancer deaths in the UK. High risk groups exist such as, immunosuppressed patients and those with the genetic condition recessive dystrophic epidermolysis bullosa whom are burdened with increased cSCC incidence, metastasis and mortality. Current clinically available molecular targets for cSCC are limited. Moreover, the key molecular events in cSCC remain poorly defined, presumably including both loss/gain of DNA or through gene silencing by DNA modifications. Understanding the molecular events which lead to cSCC is paramount for developing successful, novel molecular targets for therapeutic purpose. Preceding this thesis, our group used two independent methods to identify potential molecular targets: microarray technology (Watt 2011) and Sanger sequencing (Wang 2011), of which some of the targets identified from these studies, formulate the basis of this thesis. Using microarray technology, a comparison between gene expression profiles of cultured cSCC and normal keratinocytes, identified a gene signature specific for cSCC. From this signature, five genes were identified as being over-expressed in cSCC compared to normal and whose gene expression was important for cell survival. Subsequently, three of these genes were further explored within this thesis: germ cell associated 2 (GSG2), bradykinin receptor B1 (BDKRB1) and protease serine 21 (PRSS21). To begin, genes were confirmed to be over-expressed at both mRNA and protein level. Following this conformation, several endpoints were monitored using standard assays of cell viability, proliferation and apoptosis, in cSCC keratinocytes using gene specific siRNA. Using this validation method, PRSS21 showed the most promise as a molecular target. Depletion of PRSS21 resulted in decreased cell viability through an increase in cytotoxicity and apoptosis. Therefore PRSS21 was further validated as a molecular target through stable overexpression in an immortalised normal human cell line with no endogenous PRSS21 expression. Subsequently, using 3D organotypic cultures, it was shown that the expression of PRSS21 clearly transformed these cells into an invasive phenotype, compared to the control. Finally, PRSS21 was shown to interact with the tumour suppressor maspin, potentially negatively regulating maspin dependant apoptosis. This data strongly suggests that both PRSS21 and maspin are potential targets in cSCC. The second method of identifying molecular targets was direct sequencing of tumour DNA, which identified loss of function notch mutations in ~75% of cSCC. It has been postulated that loss of notch function contributes to cSCC through a reduction in differentiation. Using three cSCC cell lines of known notch status (wild type/loss of function/notch null), cells were grown in organotypic culture, and the expression of markers associated with differentiation studied. With the aid of a gamma secretase inhibitor to inhibit notch signalling the contribution of notch to the expression of differentiation markers was studied in cSCC cells compared to normal human keratinocytes (NHK). There was a significant reduction in differentiation within the cSCC cell lines compared to NHK, regardless of notch status, and differentiation could be further reduced by the presence of GSI in the cSCC with wild type/loss of function notch expression. Furthermore, overexpression of a gamma secretase regulatable intracellular notch1 (ICN1) construct, showed an induction of involucrin in these cells, compared to cells overexpressing an empty vector control, confirming that notch1 contributes to differentiation. Overall this work highlights the importance of validating targets before embarking on expensive, time consuming experiments. In doing so, it reveals two potential molecular targets which could be important for the progression of cSCC, PRSS21 and maspin. Additionally it confirms the potential mechanism of notch loss of function in suppressing differentiation, suggesting that its re-activation would be is a valid approach to cSCC therapy.
3

Pirzado, Muhammad Suleman. "Investigating cell senescence in basal cell carcinoma." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8633.

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The Aim of the project was to investigate cell senescence in basal cell carcinoma (BCC). Although the concept of oncogene-induced senescence (OIS) was originally confined to cultured cells, it is now well established that this mechanism has an important role in tumour biology. OIS represents a physiological response that restricts the progression of benign tumours into their malignant counterparts e.g. nevi to melanoma or adenoma to adenocarcinoma. Full malignancy is associated with the loss of important tumour suppressor genes including RETINOBLASTOMA and/or TP53. BCC of the skin is the most common skin tumour and is associated with mutational inactivation of the PTCH1 tumour suppressor gene (and less frequently oncogenic activation of SMOOTHENED). Although BCC does not appear to stem from precursor lesions - though mouse models of BCC display areas of basaloid hyperproliferation - and it is relatively stable at the genomic level, we sought to determine if these unique tumours display any characteristics of OIS. Human BCCs were positive for Senescence-associated β-galactosidase (SA-β-gal) activity (pH 6.0) and expressed known markers of senescence including DCR2, DEC1 (SHARP2) as well as the cell cycle inhibitors p15INK4b and p16INK4a. Interestingly, SA-β-gal activity was observed in stromal cells surrounding the tumour islands and this may account for why BCCs are difficult to culture in vitro as senescent cells are known to express increased levels of growth factors, cytokines and ECM proteins. To determine if OIS is associated with Hedgehog signalling in BCC, I employed a novel in vitro model of BCC created through PTCH1 suppression in human immortalised NEB1 keratinocytes. NEB1-shPTCH1 cells are viable and proliferative (albeit more slowly than control NEB1-shCON cells) and do not display SA-β-gal activity but they express higher levels of several senescent markers including DCR2 and p21WAF1. I also investigated senescence in a Mouse model of BCC in which one allele of Ptch1 is mutated and which on x-ray irradiation results in BCC formation. The expression of known markers of senescence including DCR2, DEC1 (SHARP2) as well as the cell cycle inhibitors p15INK4b, p16INK4a and p53 were all with the exception of p21WAF1 detected in these tumours. Together these data suggest that senescence is a characteristic of BCC and may explain why these tumours rarely metastasise.
4

Rose, Aidan Michael. "Transforming growth factor-beta signalling in human cutaneous squamous cell carcinoma." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/51b1a1c1-ac43-4f60-aa77-9002af3f2186.

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There is an urgent need to define the key pathological driving events in human cutaneous squamous cell carcinoma (cSCC) in order to identify novel therapeutic targets. Already the second most common form of human non-melanoma skin cancer, the incidence of cSCC has continued to rise at epidemic proportions over the past two decades. Rarely, cSCC can be highly aggressive, causing significant soft-tissue defects in sun-exposed areas of skin and progressing to metastatic disease, which is usually associated with poor survival. The transforming growth factor-β (TGF-β) signalling pathway is known to play key regulatory roles in skin homeostasis and wound repair. Murine studies indicate that loss of TGF-β signalling is sufficient to drive cSCC, but conclusive evidence for a similar role in human cSCC remains elusive. Combining immunohistochemical and genetic studies of the TGF-β signalling pathway on human cSCC tissue, with a thorough examination of TGF-β responses in human primary cSCC cell lines in-vitro, this thesis aims to investigate the complex role of TGF-β signalling in human cSCC. An extensive tissue micro-array analysis demonstrated the consistent reduction of endogenous TGF-β signalling activity in human primary cSCC. This intriguingly correlated with higher risk thick tumours pathologically, indicating that TGF-β is likely to act primarily as a tumour suppressor in human cSCC and its reduction or loss may impart a significant growth advantage for cSCC tumour cells. This tumour suppressor effect was reflected in-vitro, whereby the majority of primary cSCC cell lines remained sensitive to TGF-β mediated growth arrest. Resistance to TGF-β tumour suppression was also identified, and mechanistically its main protagonist in cSCC cell lines appeared to be mutational loss of TGF-β receptors. Consolidating in-vitro findings, both whole exome sequencing and 454 pyrosequencing of human cSCC tissue revealed frequent functionally damaging mutations of both TGF-β type 1 and type 2 receptors, indicating that mutational loss of the TGF-β pathway may be a key driving event in human cSCC tumourigenesis. Perhaps most interestingly, mutational loss of TGF-β type 2 receptors in cSCC cell lines appeared to result in a novel pro-oncogenic dependence on TGF-β type 1 receptor kinase activity, highlighting not only the important paradoxical role of TGF-β mediated tumour promotion in cSCC, but also the potential for signalling crosstalk between alternative TGF-β superfamily members, namely Activin signalling, to drive tumourigenesis in the absence of active TGF-β signalling. Although further mechanistic studies are required to support this hypothesis, the mutational status of TGF-β type 2 receptors may not only provide a powerful prognostic tool for patients with cSCC, but also represent an important biomarker for the targeted use of TGF-β inhibitors in potentially aggressive disease where pro-tumourigenic responses could be driving disease progression.
5

Dworkin, Amy Marie. "ENVIRONMENTAL AND GENETIC CONTRIBUTIONS OF SUSCEPTIBILITY TO CUTANEOUS SQUAMOUS CELL CARCINOMA." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1266000583.

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6

Ismail, Ferina. "Ultraviolet Radiation-induced Apoptosis in the Pathogenesis of Cutaneous Squamous Cell Carcinoma." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522322.

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Azimi, Ali. "PROTEOMIC ANALYSIS OF ACTINIC KERATOSIS, BOWEN’S DISEASE AND CUTANEOUS SQUAMOUS CELL CARCINOMA." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20449.

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Cutaneous squamous cell carcinoma (cSCC), premalignant actinic keratosis (AK) and Bowen’s disease (BD) are highly prevalent, heterogeneous keratinocytic skin lesions (KSLs). Discrepancies between clinical presentations and histologic analyses of KSLs frequently lead to misdiagnoses or delayed diagnoses. Biomarkers that can accurately stratify KSLs by their malignant potential are urgently needed to support a paradigm shift in skin cancer care to personalised, precision medicine. In this thesis, a liquid chromatography tandem mass spectrometry (MS) platform was employed to conduct comprehensive proteomic profiling of formalin-fixed and paraffin embedded samples of normal skin and KSLs. Using complementary MS approaches, namely information dependent acquisition (IDA) and sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS), 3574 proteins were quantified overall allowing the identification of novel protein signatures for KSL subtypes. Proteomic findings were further investigated in silico using transcriptome databases, and several interesting targets were confirmed by immunohistochemistry. Distinct proteome profiles corresponding to subcategories of cSCC and precursor lesions were found, demonstrating the potential of MS-based approaches to deliver reliable diagnostics and disease staging. The bioinformatic analysis provided new insights into molecular pathways disrupted in different KSLs. The successful application of a non-invasive tape-stripping method for proteome sampling of KSLs was also demonstrated. This work represents the most comprehensive proteome study of KSLs to date. The identification of deferentially altered proteins and molecular pathways between subtypes of KSLs will inform the development of diagnostic, therapeutic and disease staging strategies. Further exploration and implementation of the approaches described herein could have a major impact on patient outcomes and reduce the cost burden of KSLs.
8

Emich, Helena. "Clinical implications of cancer stem cell properties in oral squamous cell carcinoma." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8479.

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CD44 has been described as a marker of cancer stem cells in oral squamous cell carcinoma (OSCC). The main objective of this study was to characterise expression of CD44 in both fresh samples of human OSCC and in cell lines generated from them, and to examine its correlation with selected clinicopathological parameters of the tumours of origin. The epithelial fraction in 20 fresh OSCC samples was identified by the standard method using the negative selection technique with antibodies against non-tumour cells. A novel method of identifying the epithelial fraction, termed positive selection, was also developed and used for analysis of 14 additional OSCC samples. This new method, using epithelial-specific antibodies, led to a considerable improvement in the efficiency and the accuracy of the procedure. The frequency of CD44+ cells in the epithelial fraction of the tumour specimens was assessed by FACS and varied widely (3-97%). High frequency of CD44+ cells in tumour samples was found to be associated with high tumour grade, discohesive invasion front and presence of lymph node metastases (p<0.01, as calculated with Spearman’s ranked test and Fisher’s exact test). It was also observed, that the percentage of CD44+ cells changes when cells isolated from tumour samples are propagated in culture. Nearly all cells in cell lines generated from OSCC samples showed CD44 expression when analysed by FACS. However, a markedly higher level of CD44 expression (as assessed by median fluorescence intensity for cell surface CD44) was found for early passage cell lines generated from metastatic OSCC and lymph node metastases as compared to cell lines generated from nonmetastatic OSCC. These findings show that a high frequency of CD44+ cells in fresh OSCC tissue and a high level of CD44 expression in cultured OSCC cells correlate 11 with more aggressive tumour behaviour. These results might provide important information of prognostic and therapeutic value.
9

Martins, Vera Lisa Coelho. "Increased invasive behaviour of cutaneous squamous cell carcinoma with knock-down of Type VII collagen." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497913.

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Type Vll collagen (ColVII) is the main component of anchoring fibrils, structures within the lamina densa of the basement membrane responsible for dermal-epidermal adherence in skin. Mutations in the human ColVll gene, C0L7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae associated with a greatly increased risk of skin cancer. The aim of this study was to investigate the effect of loss of ColVII on cutaneous SCC behaviour using RNAi.
10

Mooney, Craig Paul. "Cutaneous Squamous Cell Carcinoma of the Head and Neck Identifying Metastasis and High-Risk Characteristics." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24946.

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Introduction: Head and Neck cutaneous Squamous Cell Carcinoma (HNcSCC) is one of the most common cancers in the world and is particularly prevalent in Australia. Regional metastasis remains one of the most important determinants of survival but predicting which lesions metastasise remains a challenge. Current staging systems have been shown to poorly stratify patient survival. Methodology: Three studies were initiated: (1) A prospective trial of patients with high risk primary HNcSCC underwent sentinel node biopsy (SNB) to identify subclinical metastasis. Patients were followed to determine the accuracy of SNB, overall rate of metastasis and clinicopathological predictors of metastasis. Retrospective reviews of patients with metastatic HNcSCC treated at a quaternary referral head and neck oncology service was undertaken to characterise the prognostic impact of (2) Soft tissue metastases (STM) and (3) Location (parotid v neck) of regional metastasis. Results: (1)105 high risk lesions underwent SNB with a total subclinical nodal metastasis rate of 14.3%. SNB identified 67% of patients with regional metastasis. The risk of metastasis is increased in the presence of perineural invasion and increasing depth of invasion and number of high-risk features. (2) A review of 200 patients with STM identified a poor five-year overall survival (OS) of 36% and that increasing number of deposits was a significant predictor of reduced survival on multivariable analysis. (3) A review of 535 patients with regional metastasis determined that multiple regional metastases and metastases to neck nodes were associated with reduced survival. Conclusion: Regionally metastatic HNcSCC is associated with a significant mortality rate in Australia. Methods to identify regional metastases early, before the development of multiple nodal metastases or STM, may improve survival rates. SNB is one such potential method; however, work is needed to better identify predictors of nodal metastases.
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Books on the topic "Cutaneous carcinoma":

1

Schmults, Chrysalyne D., ed. High-Risk Cutaneous Squamous Cell Carcinoma. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47081-7.

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Japanese Society for Ultrastructural Cutaneous Biology. Symposium. Merkel cells, Merkel cell carcinoma, and neurobiology of the skin: Proceedings of the 1st Symposium of the Japanese Society for Ultrastructural Cutaneous Biology held in Tokyo, Japan, 24-25 November 1999. Edited by Ono Tomomichi and Suzuki Hiroyuki. Amsterdam: Elsevier, 2000.

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Schmults, Chrysalyne D. High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management. Springer, 2016.

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Schmults, Chrysalyne D. High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management. Springer, 2018.

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Schmults, Chrysalyne D. High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management. Springer London, Limited, 2016.

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Matin, Rubeta, Jane McGregor, and Catherine Harwood. Skin cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0259.

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Skin cancer is very common in the UK, and its incidence is rising rapidly. There are two broad classes of primary skin cancer: non-melanoma and melanoma. Non-melanoma skin cancer is the commonest form (100 000 cases diagnosed annually in the UK), accounting for nine out of ten skin cancers and includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Cutaneous melanoma is less common (10 000 cases diagnosed in the UK annually) but confers a significantly worse prognosis and accounts for 75% of skin cancer related deaths. There are also a number of other, rarer, non-melanoma skin cancers (e.g. appendageal carcinomas, Merkel cell carcinoma, sarcomas, vascular malignancies, and cutaneous lymphomas); however, these account for less than 1% of all skin cancers in the UK and so will not be specifically discussed in this chapter. Cutaneous metastases can occur secondary to any internal cancer or, indeed, to skin cancer (e.g. melanoma). In most cases, cutaneous metastasis occurs after the diagnosis of a primary cancer and usually in late stages of the disease but, in some cases, it may be the first presentation, in which case it should prompt a thorough investigation for the primary malignancy.
7

Carton, James. Skin pathology. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199591633.003.0015.

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Eczemas 286Psoriasis 287Lichen planus 288Erythema multiforme 289Granuloma annulare 290Pemphigus vulgaris 291Bullous pemphigoid 292Dermatitis herpetiformis 293Erythema nodosum 294Pyoderma gangrenosum 295Skin infections 296Benign cutaneous lumps 298Basal cell carcinoma 300Squamous cell carcinoma 301Malignant melanoma ...
8

Arron, Sarah T. Fast Facts : Advanced Cutaneous Squamous Cell Carcinoma for Patients and Their Supporters: Information + Taking Control = Best Outcome. Karger AG, S., 2019.

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Arron, Sarah T. Fast Facts : Advanced Cutaneous Squamous Cell Carcinoma for Patients and Their Supporters: Information + Taking Control = Best Outcome. Karger AG, S., 2019.

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Carton, James. Skin pathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759584.003.0016.

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Abstract:
This chapter discusses skin pathology, including eczema/dermatitis, psoriasis, lichen planus, erythema multiforme, granuloma annulare, pemphigus vulgaris, bullous pemphigoid, dermatitis herpetiformis, erythema nodosum, pyoderma gangrenosum, acne vulgaris, rosacea, skin infections, benign epidermal tumours, benign melanocytic tumours, benign cutaneous soft tissue tumours, benign skin adnexal tumours, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, mycosis fungoides, mycosis fungoides, and dermatofibrosarcoma protuberans.

Book chapters on the topic "Cutaneous carcinoma":

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Requena, Luis, and Omar Sangüeza. "Tubular Carcinoma." In Cutaneous Adnexal Neoplasms, 195–200. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_17.

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Requena, Luis, and Omar Sangüeza. "Papillary Carcinoma." In Cutaneous Adnexal Neoplasms, 201–7. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_18.

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Requena, Luis, and Omar Sangüeza. "Syringoid Carcinoma." In Cutaneous Adnexal Neoplasms, 249–57. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_24.

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Requena, Luis, and Omar Sangüeza. "Cribriform Carcinoma." In Cutaneous Adnexal Neoplasms, 313–20. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_28.

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Requena, Luis, and Omar Sangüeza. "Mucinous Carcinoma." In Cutaneous Adnexal Neoplasms, 321–36. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_29.

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Requena, Luis, and Omar Sangüeza. "Sebaceous Carcinoma." In Cutaneous Adnexal Neoplasms, 945–73. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_72.

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Compton, Carolyn C., David R. Byrd, Julio Garcia-Aguilar, Scott H. Kurtzman, Alexander Olawaiye, and Mary Kay Washington. "Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas." In AJCC Cancer Staging Atlas, 357–70. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-2080-4_29.

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Eltorai, Ibrahim M. "Cutaneous Adenocystic Carcinoma." In Rare Diseases and Syndromes of the Spinal Cord, 317–18. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45147-3_95.

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Requena, Luis, and Omar Sangüeza. "Microcystic Adnexal Carcinoma." In Cutaneous Adnexal Neoplasms, 277–99. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_26.

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Requena, Luis, and Omar Sangüeza. "Adenoid–Cystic Carcinoma." In Cutaneous Adnexal Neoplasms, 301–11. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45704-8_27.

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Conference papers on the topic "Cutaneous carcinoma":

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Singh, Gajender, Sant Parkash Kataria, and Rajeev Sen. "Carcinoma uterine cervix metastasis to the skin: A rare case report." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685280.

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Introduction: Most common site of metastasis from carcinoma cervix is lung, liver, bone and brain. Cutaneous metastasis is rare occurrence in carcinoma cervix. Incidence reported ranges from 0.1 to 2%. Common morphological pattern of skin metastases are nodules, plaques and inflammatory telangiectatic lesions. Materials and Methods: A 68 years old postmenopausal female diagnosed as squamous cell carcinoma of cervix stage III B. She was given chemotherapy and radiotherapy and on regular follow up without no evidence of disease locally. After two years she presented with a sub cutaneous nodule of approximately 5x4 cm size just below the left scapula of one month duration. There was no similar swelling in any other region. It was rapidly increased in size and painful. The FNAC of the nodule showed metastatic from squamous cell carcinoma. PET scan showed metastases in bilateral lung and pelvic lymph node with no evidence of local disease. Excision biopsy of the nodule confirmed the diagnosis. Conclusion: Cutaneous metastases from carcinoma cervix are rare. Differential diagnoses include benign dermatitis, subcutaneous phycomycosis, and plaque like mycosis fungoides.
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Queiroz, Lais Martins, Pedro Henrique Ávila Perillo, Vinicius Catenassi Pereira Santos, Maria Carrijo Cunha Câmara, Lyna Maria Alves da Costa, Fernando Santos de Azevedo, and Lanúscia Morais de Santana. "AN ATYPICAL PRESENTATION OF BREAST CARCINOMA HER2." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2106.

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Introduction and Objectives: HER-2 overexpression occurs in 20% to 30% of invasive breast carcinomas. Even in localized disease, it is considered aggressive and can spread rapidly if not treated early. This report depicts the case of a patient with Luminal HER breast cancer with extensive cutaneous and lymph node disease, without visceral metastasis. Case Report: A 58-year-old woman with a lesion in the anterior thoracic region, ulcerated, painful, and friable to manipulation, with approximately 13 cm in the largest axis, initially diagnosed as dermatofibrosarcoma protuberans. The lesion evolved with rapid progression in size, 17 cm in the longest axis, and was re-biopsied, revealing invasive breast carcinoma with positive immunohistochemistry for ER (90%), RP (50%), HER2+ (3+), positive FISH, and Ki67 (20%). Staging examinations, extensive disease in the anterior thoracic region and right lymph node, other examinations were negative for visceral metastatic disease. Discussion: This case presents an atypical evolution of Luminal HER breast carcinoma in which the unusual clinical presentation delayed diagnosis. Unlike the identified common presentation, in this case, an extensive ulcerated and friable lesion on the anterior chest wall with extensive cutaneous and lymph node involvement is observed. Furthermore, we emphasized the relevance of the pathological findings for the correct identification of the tumor, since after reanalysis, the diagnosis of dermatofibrosarcoma protuberans was disregard, and the presence of molecular breast carcinoma subtype luminal HER was identified, which brings changes in prognosis and therapy. Conclusion: Therefore, a completely atypical manifestation of a luminal malignant HER mammary neoplasm, without visceral disease, is perceived. Furthermore, the importance of the clinical and pathological findings in the diagnosis and therapeutic management for the case resulting from atypical clinical manifestations is emphasized. Therefore, the importance of this report to expose a completely anomalous manifestation of breast cancer, which without a good investigation would receive incorrect treatment, is noted.
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van den Heuvel, Robert. "Improving risk classification in cutaneous squamous cell carcinoma." In Dutch Dermatology Days 2024, edited by Peter van de Kerkhof. Baarn, the Netherlands: Medicom Medical Publishers, 2024. http://dx.doi.org/10.55788/b15a4a62.

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Sakhri, S., M. Bouheni, H. Bouaziz, R. Chargui, and K. Rahal. "119 Postradiation cutaneous angiosarcoma after treatment of breast carcinoma." In IGCS 2020 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/ijgc-2020-igcs.102.

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Singhal, Savita Rani, Esha Gupta, and S. K. Singhal. "Vulvar myiasis: Atypical Presentation as carcinoma vulva." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685367.

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Myiasis is a parasitic infestation, rarely seen in the vulval region with more cases being reported in tropical, subtropical and warm temperate climate. Cutaneous myiasis can be misdiagnosed as cellulitis, leishmaniasis, sebaceous cysts, staphylococcal boil, insect bite or skin abscess. Knowledge of the characteristic clinical findings and the close inspection of skin lesions are key to diagnosing myiasis. We report a case of vulval maggots which was misdiagnosed as vulvar carcinoma and caused undue anxiety to the patient.
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Schachtel, Michael, Ben Panizza, Arturo Solares, Mitesh Gandhi, Mark Midwinter, and James Bowman. "Advanced Cutaneous Squamous Cell Carcinoma Extending to the Temporal Bone." In 30th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1702670.

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Trimmer, Casey, Sanjay Katiyar, Richard G. Pestell, Michael P. Lisanti, and Franco Capozza. "Abstract 1083: Caveolin-1 in cutaneous squamous cell carcinoma development." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1083.

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Hampras, Shalaka S., Michael Pawlita, Massimo Tommasino, Jong Park, Pearlie K. Burnette, Neil A. Fenske, Basil A. Cherpelis, and Dana E. Rollison. "Abstract 3439: Interaction between cutaneous human papillomavirus infection and telomere length in association with cutaneous squamous cell carcinoma." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3439.

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Gray, Kelsey M., Amy M. Dworkin, Jessica L. Fleming, and Amanda E. Toland. "Abstract 103: DCPS as a cutaneous squamous cell carcinoma susceptibility gene." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-103.

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Chitsazzadeh, Vida, Weimin Xiao, Preethi Gunaratne, Cristian Coarfa, Xiaoping Su, Tri H. Nguyen, Valencia D. Thomas, Aaron K. Joseph, Elsa R. Flores, and Kenneth Y. Tsai. "Abstract 815: Integrated genomic analysis of cutaneous squamous cell carcinoma progression." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-815.

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Reports on the topic "Cutaneous carcinoma":

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Bhowmik, Srishti, Anurag Mishra, Chandra Bhushan Singh, Sarmista Roy, and Vibha Singh. Malignant Transformation of Post-Nephrectomy Enterocutaneous Fistula: A Review of Literature. Science Repository, May 2024. http://dx.doi.org/10.31487/j.ajscr.2024.02.01.

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Background: Enterocutaneous fistula is an aberrant epithelialized communication between the bowel and the skin occurring mostly as a complication of abdominal surgery. Enterocutaneous fistula may present as chronically discharging sinus and like any other chronic non healing wound, malignant transformation has rarely been reported in such gastrointestinal fistula. Herein we report an additional case of malignant transformation of enterocutaneous fistula leading to duodenal mass. Case Presentation: A 50-year diabetic gentleman presented with a persistent draining sinus from his surgical site of right nephrectomy for 6 months with friable growth over the sinus opening which sheds off spontaneously to reappear again after a period. Investigations showed duodenal growth communicating to the right renal fossa and further to the skin surface in the lumbar region. Exploratory laparotomy was performed where a circumferential mass was noted in the second part of duodenum with perforation in the posterior wall. The perforation was seen to communicate with skin via fistulous tract. Postoperative biopsy of duodenal mass confirmed it to be well differentiated squamous cell carcinoma with transmural infiltration. Conclusion: When perirenal or retroperitoneal inflammation takes place, second part of the duodenum becomes involved and the absence of a protective peritoneal barrier between the two, along with the relative immobility of the duodenum, accounts for the internal drainage and fistula formation which occurs. Persistent enterocutaneous fistula after nephrectomy causes long standing pus discharge and malnourishment affecting the overall health of these patients. Chronic inflammation is known to be a risk factor for development of squamous cell carcinoma. Two previous cases of malignant transformation of post nephrectomy colocutaneous fistula have been reported. However, this case is unique as no prior reporting of malignant transformation of duodeno-cutaneous fistula was found in literature.

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