Journal articles: 'Customizable implant'

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Bezerra, Fabio Jose Barbosa, Felipe Moura Araujo, Guilherme Jose Pimentel Lopes de Oliveira, and Bruna Ghiraldini. "Clinical application of the customizable PEEK healing abutment. A case report." Journal of Multidisciplinary Dentistry 10, no. 1 (June 3, 2020): 93–6. http://dx.doi.org/10.46875/jmd.v10i1.42.

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The aim of this case report was to present an indication of the PEEK as a material of customizable healing abutment. A 35-year-old male complained about the absence of the right upper first molar that had been previously extracted (2 years) due to unsuccessful endodontic treatment. After the anamnesis, the clinical and radiographic evaluation, a good bone availability that enables a dental implants placement was observed in the edentulous region. A dental implant with hybrid microgeometry and morse taper prosthetic connection was placed. A good primary stability was obtained (32 Ncm), however, the early loading technique was opted for this case instead of the immediate loading, since the implants placed in the posterior region requires to support a high masticatory loading force which could interfere with the healing process of the dental implant. Then, a customizable PEEK healing abutment was installed in order to define the prosthetic emergence profile. There were no signs of complications during the postoperative period, and after the twenty-eight-day healing period, a prosthetic interface for digital transfer was installed and intraoral scanning was performed. The prosthetic rehabilitation was performed by the CAD/CAM system, and a screwed prosthetic rehabilitation was installed at the same day. The patient was followed up for 12 months, and no signs or symptoms of peri-implant pathology or prosthetic complications were detected. The customizable PEEK healing abutment is a good option to induce a properly soft-tissue healing that enables an adequate prosthetic emergency profile.

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Thomé, Geninho, Marcos Boaventura de Moura, Jean Uhlendorf, Carolina Accorsi Cartelli, Larissa Carvalho Trojan, and Sérgio Rocha Bernardes. "Reabilitação implantossuportada de molar superior com implante cônico interno de diâmetro extra-largo – relato de caso." Full Dentistry in Science 12, no. 46 (2021): 53–58. http://dx.doi.org/10.24077/2021;1246-5358.

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Tooth loss can occur due to several factors including dental caries. Immediate replacement of posterior teeth with dental implants facilitates to plan and to obtain consistent results with good prognosis. Factors such as minimally traumatic extraction, primary implant stability, maintenance of proximal bone ridges, buccal and lingual bone plates, in addition to a temporary or customizable component for tissue stabilization are important parameters to make the case predictable. The immediate technique for implants placement in the posterior regions has been described in the literature since the 1990s, presenting a high success rate and predictability of patients rehabilitation with shorter waiting times and maintenance of soft and bone tissue architecture. This study reports a clinical case of extraction of an upper molar tooth (26) with dental caries and placement of an extra-wide diameter implant, followed by filling of the surgical alveolar socket with bioactive calcium phosphate ceramic and placement of a customizable healing abutment. Clinical and radiographic control was performed after 8 months with success, with maintenance of soft tissue and marginal bone.

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Junior, Joao Moretti, Cristiane de Oliveira Iamada Moretti, Diego henrique Rossafa Crocco, Gislaine Cristina dos Santos Silva Souza, and Marina Magri Porto. "Manutenção do perfil gengival com cicatrizador personalizado em implante imediato – relato de caso." Prosthesis and Esthetics in Science 10, no. 39 (2021): 17–20. http://dx.doi.org/10.24077/2021;10391720.

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This article aimed to present a clinical case whose cicatrizador was made through the multifunctional component of PEEK. This is a biocompatible polymer that is customizable and has good adhesion to resins. The case described is an immediate implant in the region of 15, installed with a palatal approach and filling the vestibular gap with an alloplastic graft (Nanosynt). The case was followed until the final prosthesis was made, in which the maintenance of the architecture of the peri-implant tissues was checked for health and aesthetics.

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Luis, Eric, Houwen Matthew Pan, Swee Leong Sing, Ram Bajpai, Juha Song, and Wai Yee Yeong. "3D Direct Printing of Silicone Meniscus Implant Using a Novel Heat-Cured Extrusion-Based Printer." Polymers 12, no. 5 (May 1, 2020): 1031. http://dx.doi.org/10.3390/polym12051031.

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The first successful direct 3D printing, or additive manufacturing (AM), of heat-cured silicone meniscal implants, using biocompatible and bio-implantable silicone resins is reported. Silicone implants have conventionally been manufactured by indirect silicone casting and molding methods which are expensive and time-consuming. A novel custom-made heat-curing extrusion-based silicone 3D printer which is capable of directly 3D printing medical silicone implants is introduced. The rheological study of silicone resins and the optimization of critical process parameters are described in detail. The surface and cross-sectional morphologies of the printed silicone meniscus implant were also included. A time-lapsed simulation study of the heated silicone resin within the nozzle using computational fluid dynamics (CFD) was done and the results obtained closely resembled real time 3D printing. Solidworks one-convection model simulation, when compared to the on-off model, more closely correlated with the actual probed temperature. Finally, comparative mechanical study between 3D printed and heat-molded meniscus is conducted. The novel 3D printing process opens up the opportunities for rapid 3D printing of various customizable medical silicone implants and devices for patients and fills the current gap in the additive manufacturing industry.

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Fischer, C. M. Maximilian, W. John Schlasche, Stefan Schröder, J. Philippe Kretzer, M. Moritz Innmann, and Tobias Renkawitz. "Additive Fertigung hybrider Hüftimplantate/HybridHipProcess – Manufacturing of customizable stiffness-optimized hip stems – Additive Manufacturing of Hybrid Hip Implants." wt Werkstattstechnik online 112, no. 05 (2022): 292–96. http://dx.doi.org/10.37544/1436-4980-2022-05-22.

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Unter Verwendung der additiven Fertigungstechnologie lassen sich Implantate in biomechanisch angepasster, hybrider Leichtbauweise mit einer dem natürlichen Knochen angenäherten Steifigkeit herstellen. Der Einsatz eines Homogenisierungsansatzes für die optimierten Implantatbereiche mit Gitterstrukturen erlaubt durch eine deutliche Verkürzung der Simulationszeiten eine Integration einer verzugskompensierenden und temperaturstabilisierenden Prozesssimulation der additiven Fertigung in eine individualisierte Serienproduktion. Implants with a biomechanically customized hybrid lightweight design that is adapted to the stiffness of the native bone can be produced using additive manufacturing technology. The use of a homogenization approach for the optimized implant areas with lattice structures enables the integration of a process simulation of the additive manufacturing process including a distortion compensation and temperature stabilization into a customized serial production by a considerable reduction of the simulation time.

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Blonde, Jackson D., Megan Roussy, Rogelio Luna, Borna Mahmoudian, Roberto A. Gulli, Kevin C. Barker, Jonathan C. Lau, and Julio C. Martinez-Trujillo. "Customizable cap implants for neurophysiological experimentation." Journal of Neuroscience Methods 304 (July 2018): 103–17. http://dx.doi.org/10.1016/j.jneumeth.2018.04.016.

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Rathore, Lakshya P., and Naina Verma. "Additive manufacturing in medical sciences: past, present and the future." International Journal of Research in Orthopaedics 5, no. 1 (December 25, 2018): 201. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20185345.

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Additive manufacturing (AM) is a novel technique that despite having been around for more than 35 years, has been underutilized. Its great advantage lies in the basic fact that it is incredibly customizable. Since its use was recognized in various fields of medicine like orthopaedics, otorhinolaryngology, ophthalmology etc, it has proved to be one of the most promising developments in most of them. Customizable orthotics, prosthetics and patient specific implants and tracheal splints are few of its advantages. And in the future too, the combination of tissue engineering with AM is believed to produce an immense change in biological tissue replacement.

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Li, Cuidi, Xiaoyu Han, Zhenjiang Ma, Tianyang Jie, Jinwu Wang, Lianfu Deng, and Wenguo Cui. "Engineered Customizable Microvessels for Progressive Vascularization in Large Regenerative Implants." Advanced Healthcare Materials 11, no. 4 (November 28, 2021): 2101836. http://dx.doi.org/10.1002/adhm.202101836.

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Weksler, Benny. "Commentary: Three-dimensional printing and customizable implants: The future is now." JTCVS Techniques 8 (August 2021): 216–17. http://dx.doi.org/10.1016/j.xjtc.2021.05.006.

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El-Habashy, Salma E., Amal H. El-Kamel, Marwa M. Essawy, Elsayeda-Zeinab A. Abdelfattah, and Hoda M. Eltaher. "3D printed bioinspired scaffolds integrating doxycycline nanoparticles: Customizable implants for in vivo osteoregeneration." International Journal of Pharmaceutics 607 (September 2021): 121002. http://dx.doi.org/10.1016/j.ijpharm.2021.121002.

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Li, Cuidi, Xiaoyu Han, Zhenjiang Ma, Tianyang Jie, Jinwu Wang, Lianfu Deng, and Wenguo Cui. "Engineered Customizable Microvessels for Progressive Vascularization in Large Regenerative Implants (Adv. Healthcare Mater. 4/2022)." Advanced Healthcare Materials 11, no. 4 (February 2022): 2270024. http://dx.doi.org/10.1002/adhm.202270024.

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Elsadek, Nehal E., Abdalrazeq Nagah, Tarek M. Ibrahim, Hitesh Chopra, Ghada A. Ghonaim, Sherif E. Emam, Simona Cavalu, and Mohamed S. Attia. "Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine." Materials 15, no. 5 (March 4, 2022): 1934. http://dx.doi.org/10.3390/ma15051934.

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Electrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF’s pros is to provide a controlled drug release through managing the NF structure by changing the spinneret type and nature of the used polymer. Electrospun NFs are employed as implants in several applications including, cancer therapy, microbial infections, and regenerative medicine. These implants facilitate a unique local delivery of chemotherapy because of their high loading capability, wide surface area, and cost-effectiveness. Multi-drug combination, magnetic, thermal, and gene therapies are promising strategies for improving chemotherapeutic efficiency. In addition, implants are recognized as an effective antimicrobial drug delivery system overriding drawbacks of traditional antibiotic administration routes such as their bioavailability and dosage levels. Recently, a sophisticated strategy has emerged for wound healing by producing biomimetic nanofibrous materials with clinically relevant properties and desirable loading capability with regenerative agents. Electrospun NFs have proposed unique solutions, including pelvic organ prolapse treatment, viable alternatives to surgical operations, and dental tissue regeneration. Conventional ES setups include difficult-assembled mega-sized equipment producing bulky matrices with inadequate stability and storage. Lately, there has become an increasing need for portable ES devices using completely available off-shelf materials to yield highly-efficient NFs for dressing wounds and rapid hemostasis. This review covers recent updates on electrospun NFs in nanomedicine applications. ES of biopolymers and drugs is discussed regarding their current scope and future outlook.

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Passos, Marina, Sergej Zankovic, Graça Minas, Enno Klüver, Marit Baltzer, Hagen Schmal, and Michael Seidenstuecker. "About 3D Printability of Thermoplastic Collagen for Biomedical Applications." Bioengineering 9, no. 12 (December 7, 2022): 780. http://dx.doi.org/10.3390/bioengineering9120780.

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With more than 1.5 million total knee and hip implants placed each year, there is an urgent need for a drug delivery system that can effectively support the repair of bone infections. Scaffolds made of natural biopolymers are widely used for this purpose due to their biocompatibility, biodegradability, and suitable mechanical properties. However, the poor processability is a bottleneck, as highly customizable scaffolds are desired. The aim of the present research is to develop a scaffold made of thermoplastic collagen (TC) using 3D printing technology. The viscosity of the material was measured using a rheometer. A 3D bioplotter was used to fabricate the scaffolds out of TC. The mechanical properties of the TC scaffolds were performed using tension/compression testing on a Zwick/Roell universal testing machine. TC shows better compressibility with increasing temperature and a decrease in dynamic viscosity (η), storage modulus (G′), and loss modulus (G″). The compressive strength of the TC scaffolds was between 3–10 MPa, depending on the geometry (cylinder or cuboid, with different infills). We have demonstrated for the first time that TC can be used to fabricate porous scaffolds by 3D printing in various geometries.

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Luo, Yangyang, Ahmed Humayun, and David K. Mills. "Surface Modification of 3D Printed PLA/Halloysite Composite Scaffolds with Antibacterial and Osteogenic Capabilities." Applied Sciences 10, no. 11 (June 8, 2020): 3971. http://dx.doi.org/10.3390/app10113971.

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Three-dimensional (3D) printing techniques have received considerable focus in the area of bone engineering due to its precise control in the fabrication of complex structures with customizable shapes, internal and external architectures, mechanical strength, and bioactivity. In this study, we design a new composition biomaterial consisting of polylactic acid (PLA), and halloysite nanotubes (HNTs) loaded with zinc nanoparticles (PLA+H+Zn). The hydrophobic surface of the 3D printed scaffold was coated with two layers of fetal bovine serum (FBS) on the sides and one layer of NaOH in the middle. Additionally, a layer of gentamicin was coated on the outermost layer against bacterial infection. Scaffolds were cultured in standard cell culture medium without the addition of osteogenic medium. This surface modification strategy improved material hydrophilicity and enhanced cell adhesion. Pre-osteoblasts cultured on these scaffolds differentiated into osteoblasts and proceeded to produce a type I collagen matrix and subsequent calcium deposition. The 3D printed scaffolds formed from this composition possessed high mechanical strength and showed an osteoinductive potential. Furthermore, the external coating of antibiotics not only preserved the previous osteogenic properties of the 3D scaffold but also significantly reduced bacterial growth. Our surface modification model enabled the fabrication of a material surface that was hydrophilic and antibacterial, simultaneously, with an osteogenic property. The designed PLA+H+Zn may be a viable candidate for the fabrication of customized bone implants.

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Smith, Linda Ann, Erika N. Nelums, Margaret B. Snyder, and Robert R. Kuske. "Use of a 3-dimensional lumpectomy marker for targeting interstitial accelerated partial breast irradiation (APBI)." Journal of Clinical Oncology 33, no. 28_suppl (October 1, 2015): 42. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.42.

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42 Background: APBI via high-dose-rate (HDR) interstitial catheter implants is an effective, highly customizable method of delivering radiotherapy in breast cancer patients. The technique is amenable to challenging anatomy such as pendulous and/or very small breasts, augmented breasts or superficial lumpectomy sites. The challenge for any APBI technique is identification of the lumpectomy cavity, which can be difficult to visualize after surgery due to post-surgical changes or tissue mobilization for oncoplastic closure. In the past we have used x-ray contrast injected into the cavity to facilitate the radiographic visualization of the cavity or individual clips. A new 3-D tissue marker (BioZorb, Focal Therapeutics, Inc.) has recently been used by surgeons to mark the area of the lumpectomy cavity at greatest risk for recurrence. In effect this acts as a communication tool to help guide the radiation oncologist for treatment planning and delivery. We examined this device for target volume localization in 15 patients receiving interstitial HDR APBI. Methods: The marker mimicking the tumor size was surgically sutured at the base of the lumpectomy cavity in 15 patients with T1T2N0N1 breast cancer with a variety of closure techniques. The clinical target volume (CTV) was taken as the 3-D outline made by the six embedded titanium markers and a 2 cm margin expanded around that structure (the planning target volume, PTV). Multiple interstitial catheters were spaced 1.5 cm apart within the PTV and 34 Gy was delivered in 10 fractions delivered over 5 treatment days. Results: The marker/CTV was easily visualized on CT images, without clips or injected contrast, making catheter insertion and planning more efficient, easier, and reproducible. The CTV volume was small (12.5 +/- 8.7cc; mean +/- SD, range 4.4–33.4cc) as was the PTV (137 +/- 60cc; mean +/- SD, range 75–327cc), relative to typical HDR APBI implants. Conclusions: The technique facilitated identification of the lumpectomy cavity in all patients treated regardless of surgical closure technique. The unambiguous margin demarcation facilitated target contouring and reproducibility for APBI.

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Cohen, Samuel A., Jonathan D. Tijerina, Linus Amarikwa, Clara Men, and Andrea L. Kossler. "#PlasticsTwitter: The Use of Twitter Data as a Tool for Evaluating Public Interest in Cosmetic Surgery Procedures." Aesthetic Surgery Journal 42, no. 5 (December 28, 2021): NP351—NP360. http://dx.doi.org/10.1093/asj/sjab429.

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Abstract Background Plastic surgeons are increasingly turning to social media to market their services. The newly released Twitter Academic Research Product Track (TARPT) database provides free, customizable analysis of keywords that are included in tweets on the Twitter platform. The TARPT tool may provide valuable insight into public interest in cosmetic surgery procedures. Objectives The aim of this study was to determine TARPT’s utility in tracking and predicting public interest in cosmetic surgery procedures and to examine temporal trends in tweets related to cosmetic facial and body procedures. Methods The TARPT tool was used to calculate the total number of tweets containing keywords related to 10 facial cosmetic procedures and 7 cosmetic body procedures from 2010 to 2020. Annual volumes for respective procedures were obtained from annual statistics reports of The Aesthetic Society from 2010 to 2020. Tweet volumes and procedure volumes were compared by univariate linear regression, taking P < 0.05 as the cutoff for significance. Results Variations in tweet volume were observed. Univariate linear regression analysis demonstrated statistically significant positive correlations between tweet volumes and procedure volumes for 7 search terms: “eyelid lift,” “facelift,” “lip injections,” “mastopexy,” “butt lift,” “butt implants,” and “liposuction.” Many procedure-related keywords were not significant, demonstrating the importance of careful selection of Twitter search terms. Conclusions The TARPT database represents a promising novel source of information for plastic surgeons, with the potential to inform marketing and advertising decisions for emerging trends in plastic surgery interest before these patterns become apparent in surgical or clinical volumes.

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Rau, Thomas S., Jakob Cramer, M. Geraldine Zuniga, Georg Böttcher, and Thomas Lenarz. "A method for image-guided positioning of cochlear specimens in insertion test benches using 3D printed stands." Current Directions in Biomedical Engineering 7, no. 2 (October 1, 2021): 105–8. http://dx.doi.org/10.1515/cdbme-2021-2027.

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Abstract Cochlear implants include an electrode array (EA) which needs to be inserted into the cochlea. Insertion tests using artificial cochlear models (ACM) or ex vivo specimens are widely used methods during EA development to characterize EA design properties, including insertion forces. Measured forces are directly linked to the orientation of the cochlear lumen with respect to the insertion axis of the test bench. While desired insertion directions in ACM experiments can be predefined by design, specimens are individually shaped and the cochlear lumen is embedded invisibly. Therefore, a new method for accurate, individual specimen positioning is required. A key element of the proposed method is a customizable pose setting adapter (PSA) used to adjust the specimen’s fine positioning. After rigid fixation of the specimen to a holder featuring spherical registration markers and subsequent cone beam computed tomography the desired insertion direction is planned. The planned data is used to calculate the individual shape of the PSA. Finally, the PSA is 3D printed and mounted between force sensor and specimen holder to correctly align the specimen to the test bench’s insertion axis. All necessary hard- and software have been developed including the specimen holder, a software for registration and trajectory planning, and a custom Matlab script whose output drives a parametric CAD file of the PSA. Positioning accuracy was determined in a first trial using 10 virtual trajectories and was found to be 0.23 ± 0.12 mm and 0.38 ± 0.17°. The presented stereotactic positioning procedure enables high repeatability in future ex vivo insertion experiments due to accurate, image-guided control of the insertion direction.

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Dodgen, Eric, Eric Stratton, Anton Bowden, and Larry Howell. "Spinal Implant Development, Modeling, and Testing to Achieve Customizable and Nonlinear Stiffness." Journal of Medical Devices 6, no. 2 (May 7, 2012). http://dx.doi.org/10.1115/1.4006543.

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The spine naturally has a nonlinear force-deflection characteristic which facilitates passive stability, and thus there is a need for spinal implants that duplicate this behavior to provide stabilization when the spine loses stiffness through injury, degeneration, or surgery. Additionally, due to the complexity and variability in the mechanics of spinal dysfunction, implants could potentially benefit from incorporating a customizable stiffness into their design. This paper presents a spinal implant with contact-aided inserts that provide a customizable nonlinear stiffness. An analytical model was utilized to optimize the device design, and the model was then verified using a finite element model. Validation was performed on physical prototypes, first in isolation using a tensile tester and then using cadaveric testing on an in-house spine tester. Testing confirmed the performance of the implant and it was observed that the device increased mechanical stability to the spinal segment in flexion-extension and lateral-bending.

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Tan, Fei, and Mohamed Al-Rubeai. "Customizable Implant-specific and Tissue-Specific Extracellular Matrix Protein Coatings Fabricated Using Atmospheric Plasma." Frontiers in Bioengineering and Biotechnology 7 (September 27, 2019). http://dx.doi.org/10.3389/fbioe.2019.00247.

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Ohtsu, Naofumi, Yuko Kakuchi, Toyofumi Takahara, and Yutaka Yoshida. "A facile chemical process to form an ultrathin hydroxyapatite layer with a customizable silver‐releasing function on a titanium implant." Journal of Biomedical Materials Research Part B: Applied Biomaterials, September 20, 2021. http://dx.doi.org/10.1002/jbm.b.34937.

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Minor, Alicia, Stephanie Roser, Keyana Zahiri, Elena Song, Momoka Kobayashi, Collin Polucha, and Kareen L. Coulombe. "Abstract P1142: Engineering Vascular Therapies With Angiogenic Factors For Cardiac Regeneration And Tissue Remodeling." Circulation Research 131, Suppl_1 (August 5, 2022). http://dx.doi.org/10.1161/res.131.suppl_1.p1142.

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The limited regenerative capacity of the adult human heart presents a critical need to stabilize and support injured heart muscle to mitigate the progression of heart failure. The effectiveness of remuscularization therapies using human induced pluripotent stem cell derived cardiomyocytes depends host mediated angiogenesis to direct the formation of stable, perfused vascular networks within the engineered cardiac implant. We hypothesize that potent combinations of growth factors will stimulate angiogenesis in the myocardium and increase vascular development in engineered cardiac tissue. In a fractional factorial experiment, we assessed the effect of ten growth factors, cytokines and enzymes: VEGF, bFGF, Shh, PDGF, IGF-1, EGF, TGF-β1, Ang-1, MCP-1 and MMP-9 on in vivo angiogenesis in a subcutaneous Matrigel plug assay in the rat. Five factors were highly potent by metrics of vessel density and vascular cell recruitment in explants and warranted further investigation. We then designed a two-level, fractional factorial experiment using a defined collagen-alginate gel to deliver high/low doses of these 5 factors subcutaneously to elucidate main effects and two-way interactions that regulate vessel development in vivo . After 7 days, Griffonia Simplicfolia lectin I was administered to label perfused vasculature then explants were removed and processed for immunohistochemistry. Our data show that 3 unique cocktails yielded a 10-fold increase in lumen density, a 3.3-fold increase in lumen size, and a 3.7-fold increase in endothelial cell recruitment relative to unloaded controls. Ongoing analyses will determine which angiogenic cocktail to deliver in a customizable biomaterial-based vascular therapy for applications in the heart. This novel therapy will be delivered with an engineered cardiac tissue onto the epicardium in a rat I/R MI model to quantify vascular remodeling in the implant and underlying host tissue and whole heart function over 4 weeks. In conclusion, we have identified five potent angiogenic factors for modulating revascularization responses and our ongoing work aims to understand the potential synergy between revascularization and remuscularization therapies for heart regeneration.

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Inacio, Jordan V., Danielle M. Cristino, Michael W. Hast, and Hannah L. Dailey. "An Adaptable Computed Tomography-Derived Three-Dimensional-Printed Alignment Fixture Minimizes Errors in Radius Biomechanical Testing." Journal of Biomechanical Engineering 143, no. 11 (July 19, 2021). http://dx.doi.org/10.1115/1.4051433.

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Abstract Biomechanical testing of long bones can be susceptible to errors and uncertainty due to malalignment of specimens with respect to the mechanical axis of the test frame. To solve this problem, we designed a novel, customizable alignment and potting fixture for long bone testing. The fixture consists of three-dimensional-printed components modeled from specimen-specific computed tomography (CT) scans to achieve a predetermined specimen alignment. We demonstrated the functionality of this fixture by comparing benchtop torsional test results to specimen-matched finite element models and found a strong correlation (R2 = 0.95, p < 0.001). Additional computational models were used to estimate the impact of malalignment on mechanical behavior in both torsion and axial compression. Results confirmed that torsion testing is relatively robust to alignment artifacts, with absolute percent errors less than 8% in all malalignment scenarios. In contrast, axial testing was highly sensitive to setup errors, experiencing absolute percent errors up to 50% with off-center malalignment and up to 170% with angular malalignment. This suggests that whenever appropriate, torsion tests should be used preferentially as a summary mechanical measure. When more challenging modes of loading are required, pretest clinical-resolution CT scanning can be effectively used to create potting fixtures that allow for precise preplanned specimen alignment. This may be particularly important for more sensitive biomechanical tests (e.g., axial compressive tests) that may be needed for industrial applications, such as orthopedic implant design.

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Naderi, Armaghan, and Genevieve Palardy. "Comparison of microstructure and tensile behavior of hydroxyapatite-coated PEEK meshes and cellulose-based fabrics and mats." Journal of Industrial Textiles, January 17, 2022, 152808372110700. http://dx.doi.org/10.1177/15280837211070021.

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Polymeric biomaterials, such as polyether ether ketone (PEEK) and cellulose, have been explored as scaffolds for bone tissue engineering in the past decade. In this study, microstructure and mechanical behavior of uncoated and hydroxyapatite (HA)-coated polymeric meshes, fabrics, and mats were investigated. Commercially available monofilament PEEK meshes, and cellulose fabrics and mats were selected, then coated with a customized low temperature sol–gel method (≤ 150°C). Adhesive HA coating consisting of HA, β-TCP, and CaO with nanorod structure was derived. After HA coating, porosity of substrates (except filter-paper cellulose mats) decreased by up to 43%, indicating effective coating. Both uncoated and HA-coated substrates’ degradation rate in phosphate-buffered saline decreased after day 3. This is a result of ion precipitation or calcium compounds formation, indicating potential stability in biofluids for an extended period of time. Regarding tensile test results, highest tensile strength and elongation at break were obtained for PEEK meshes (approximately 80 MPa and 35%, respectively), as a result of the bulk material properties. HA coating did not significantly affect the tensile properties of the specimens, except for cellulose mats with an initial porosity of 77% (tensile modulus increased by 270% and strength by 210%). The increase in tensile properties could be attributed to increased rigidity, resulting from the adhesion between HA coating and cellulose fibers. Overall, HA-coated cellulose mats and PEEK meshes show promise as customizable, flexible scaffolds for implant applications and bone regeneration for future work.

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"Bioboard." Asia-Pacific Biotech News 12, no. 13 (November 2008): 5–19. http://dx.doi.org/10.1142/s0219030308000803.

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AUSTRALIA – New Stem Cell Center Gives Hope for Stroke Damage. AUSTRALIA – Sun Beds Killing 43 Aussies A Year. CHINA – Chinese Skin Cream Recalled After Steroid Found. CHINA – UN Urges China to Revamp Food Safety after Milk Crisis. CHINA – Key Proteins Identified In the Quest for Male Contraceptive. CHINA – Gene that May Contribute to Improved Rice Yield Identified. CHINA – A New Institution to be Formed by Teaming up Biological Institutes in Beijing. CHINA – Big Pharma Ranks China as No. 1 Destination in Asia for Pharmaceutical Outsourcing. INDIA – Reliance Life Sciences Launches India's First Portal for Breast Cancer Genomics. INDIA – New Health Scheme Launched in Kerala. INDIA – Nobel Biocare Introduces New Dental Implant Program in India. INDIA – Malaria Drug through Synthetic Biology. JAPAN – Sleep Disorder Due to Genetic Mutation. NEW ZEALAND – Crop and Food and Hortresearch to Merge. SINGAPORE – NUS Researchers Create Antibody that may Eradicate Viral Diseases. SINGAPORE – AMO Opens Eye-Care Training Center in Singapore. SINGAPORE – Singapore and New Zealand Set Up First Joint R&D Research Fund in Heart Disease and Cancer. SINGAPORE – More Singaporeans Expected to Seek Help for Clinical Depression, Anxiety. SINGAPORE – Moleac Launches Presence in Europe. SINGAPORE – New Study Shows Heterogeneity in Brain Tumor Cells-of-Origin. SINGAPORE – Singapore Launches New Cancer Research Centre of Excellence (CRCE) to Study Asian Cancers. SINGAPORE – Scientists Identify Gene that May Make Humans More Vulnerable to Pulmonary Tuberculosis. SINGAPORE – BioServe Introduces Customizable DNA Panels for Genetic Research. TAIWAN – Unitech Launches Its Healthcare PDA to Catch Medical Market Trend. TAIWAN – Controversies Around the Set-up of Heavy-Ion Therapy Facility in Taiwan. TAIWAN – Researchers Find Method to Extract DHA from Algae.

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Willis, Alexander R., Joseph A. Ippolito, Francis R. Patterson, Joseph Benevenia, and Kathleen S. Beebe. "Customizable orthopaedic oncology implants: one institution’s experience with meeting current IRB and FDA requirements." SpringerPlus 5, no. 1 (July 4, 2016). http://dx.doi.org/10.1186/s40064-016-2696-1.

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Zhang, Lin, Zongwen Zhang, Hannah Weisbecker, Haifeng Yin, Yihan Liu, Tianhong Han, Ziheng Guo, et al. "3D morphable systems via deterministic microfolding for vibrational sensing, robotic implants, and reconfigurable telecommunication." Science Advances 8, no. 51 (December 21, 2022). http://dx.doi.org/10.1126/sciadv.ade0838.

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DNA and proteins fold in three dimensions (3D) to enable functions that sustain life. Emulation of such folding schemes for functional materials can unleash enormous potential in advancing a wide range of technologies, especially in robotics, medicine, and telecommunication. Here, we report a microfolding strategy that enables formation of 3D morphable microelectronic systems integrated with various functional materials, including monocrystalline silicon, metallic nanomembranes, and polymers. By predesigning folding hosts and configuring folding pathways, 3D microelectronic systems in freestanding forms can transform across various complex configurations with modulated functionalities. Nearly all transitional states of 3D microelectronic systems achieved via the microfolding assembly can be easily accessed and modulated in situ, offering functional versatility and adaptability. Advanced morphable microelectronic systems including a reconfigurable microantenna for customizable telecommunication, a 3D vibration sensor for hand-tremor monitoring, and a bloomable robot for cardiac mapping demonstrate broad utility of these assembly schemes to realize advanced functionalities.

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Journal articles on the topic 'Customizable implant'

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