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Author: Grafiati
Published: 18 May 2024

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1

Yu, Zhou, Yao Yan, and Ying Lou. "Curcuma longa Linn extract suppresses neuronal apoptosis induction by sevoflurane via activation of the ERK1/2 pathway." Tropical Journal of Pharmaceutical Research 20, no. 2 (January 12, 2022): 269–74. http://dx.doi.org/10.4314/tjpr.v20i2.7.

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Purpose: To investigate Curcuma longa Linn against neuronal damage induced by exposure to sevoflurane during surgical procedures. Methods: A sealed box made of transparent glass was used for anaesthetic exposure of neurons. The neurons were exposed to Curcuma longa Linn at doses of 1.5, 3, 6 and 12 μM prior to viability assessment using MTT assay. The effect of Curcuma longa Linn treatment on protein expression was determined using western blotting. Results: Sevoflurane exposure led to significant and time-dependent reductions in neuronal proliferation, when compared to unexposed cells (p < 0.05). Curcuma longa Linn at doses of 1.5, 3, 6 and 12 μM significantly decreased sevoflurane-mediated neuronal apoptosis. It reduced cleaved caspase-3 and Bax levels in neurons. However, the Curcuma longa Linn-mediated inhibition of sevoflurane-induced neuronal apoptosis was significantly suppressed by VPC23019 (p < 0.05). The p- ERK1/2 level was dose-dependently up-regulated in neurons exposed to sevoflurane on treatment with Curcuma longa Linn. Moreover, VPC23019 reversed the upregulatory effect of Curcuma longa Linn on p-ERK1/2 expression in sevoflurane-exposed neurons (p < 0.05). Conclusion: Curcuma longa Linn reversed sevoflurane-induced neuronal apoptosis by elevating p- ERK1/2 expression. Therefore, Curcuma longa Linn exerts inhibitory effect on anaesthesia-induced apoptosis in neurons, and may be useful for the treatment of this condition.
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2

Nurhayani and Eko Avianto. "Antibacterial Activity of Turmeric Rhizome Extract (Curcuma longa Linn.) Against Staphylococcus aureus: A Systematic Literature Review." Open Access Indonesian Journal of Medical Reviews 2, no. 5 (July 1, 2022): 276–81. http://dx.doi.org/10.37275/oaijmr.v2i5.228.

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Staphylococcus aureus is a normal flora that exists in the upper respiratory tract but can cause infection if found in amounts that are more than the normal limit (>110 CFU/ml). One of the herbal medicinal plants that is widely used in Indonesia is turmeric (Curcuma longa Linn.). Turmeric rhizome (Curcuma longa Linn.) contains active substances that have antibacterial properties, such as curcumin, flavonoids, alkaloids, saponins, and tannins. To determine the antibacterial activity of turmeric (Curcuma longa Linn.) rhizome extract against the growth of Staphylococcus aureus bacteria. This research method is a literature review study. Data collection techniques through Google Scholar, Science Direct, and Pubmed with a time limit of the last 5 years will be eliminated according to the restriction criteria. There were 2005 articles that were found and then excluded according to the restriction criteria. 15 articles were found to be reviewed. Turmeric rhizome extract (Curcuma longa Linn.) has antibacterial activity against Staphylococcus aureus bacteria.
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3

Halimatushadyah, Ernie, and Ani Rahayu. "Anticancer Activity of Turmeric Rhizome Extract (Curcuma longa Linn) In-vitro Against MCF7 Breast Cancer Line Cells." Health Information : Jurnal Penelitian 15, no. 2 (July 11, 2023): 164–71. http://dx.doi.org/10.36990/hijp.v15i2.914.

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Turmeric or Curcuma longa Linn is one of the native spices and medicinal plants from Southeast Asia. Turmeric contains a compound named curcumin. Curcumin (diferuloylmethane) is a yellow pigment in turmeric that is widely used as a spice, food coloring (curry) and preservative. Curcumin shows various pharmacological effects that have been reported scientifically in research, one of which is as an anticancer. This study aims to perform a cytotoxic test of turmeric rhizome extract (Curcuma longa Linn) in-vitro with the Microtetrazolim (MTT) assay method to grasp and determine the effect of preventing the growth of MCF7 breast cancer cells, so that the IC50 value can be known. In this study, it was found that turmeric rhizome extract can be used as a natural ingredient that has the potential to inhibit the growth of MCF7 breast cancer cells. Turmeric rhizome extract has the effectiveness to inhibit the growth of MCF7 breast cancer cells with an IC50 value of 26.30 ppm. This value is categorized as moderate or moderately active cytotoxic.
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4

Azzahra, Nadya Fithrie, Retno Indrawati, and Indeswati Diyatri. "Cytotoxicity of Turmeric Extract (Curcuma longa linn.) on BHK21 Fibroblast Cells." International Journal of Science and Society 6, no. 1 (January 5, 2024): 185–209. http://dx.doi.org/10.54783/ijsoc.v6i1.1005.

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Wound healing is the process of recovery from injury to stop bleeding, and fibroblasts play a crucial role in the healing process and contribute to the regeneration of periodontal tissue. Turmeric extract (Curcuma longa linn.) is an alternative treatment that uses natural ingredients with antibacterial, antioxidant, and anti-inflammatory properties. The aim of this study is to demonstrate the toxicity of turmeric extract (Curcuma longa linn.) on BHK21 fibroblast cells. Turmeric extract (Curcuma longa linn.) was administered at concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78% to BHK-21 fibroblast cells, and its cytotoxicity was tested using the MTT Assay. The research results show that the percentage viability of fibroblast cells decreases successively with concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78%, with the highest percentage at a turmeric extract concentration of 0.78% and the lowest at a concentration of 100%. The conclusion of this study is that turmeric extract (Curcuma longa linn.) is not cytotoxic to BHK-21 fibroblast cells at concentrations of 0.78%, 1.56%, and 3.12%.
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5

Irham, Wardatul Husna, and Rini Hardiyanti. "WOUND HEALING BIOACTIVITY OF Curcuma Longa Linn." Rasayan Journal of Chemistry 14, no. 04 (2021): 2386–91. http://dx.doi.org/10.31788/rjc.2021.1446345.

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6

Krup, Vasavda, Hegde Prakash L, Harini A, and KN Sunil Kumar. "Atlas for authentication of Curcuma longa Linn." Journal of Ayurveda Medical Sciences 1, no. 1 (October 1, 2016): 46–50. http://dx.doi.org/10.5530/jams.2016.1.8.

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7

Chandio, Khushboo, Bashir Khan, Omer Farooq, Mubarik Ali, Ayesha Mukhtar, and Muhammad Munaam Ijaz. "The Pharmacological Effects of Curcuma Longa Linn in Wound Healing and Relieving Inflammation." Global Drug Design & Development Review VII, no. III (September 30, 2022): 20–29. http://dx.doi.org/10.31703/gdddr.2022(vii-iii).04.

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Curcuma Longa is the scientific name of turmeric, a member of the Zingiberaceae family of plants. It has been used in Ayurvedic medicine in different countries since long ago. But now, it is more popularly known for its wound-healing and inflammation-relieving properties. Curcumin is the biologically active ingredient responsible for these actions of Curcuma Longa. It acts at different stages of wound healing and makes it heal more quickly. It prevents inflammation and helps the immune system of the body. It also exhibits more pharmacological properties like anti-cancerous, anti-microbial, anti-diabetic, etc. This review will explain how curcumin heals wounds and acts as an antioxidant and anti-inflammatory. Moreover, this will also shed light on the latest formulations of curcumin, treating wounds and inflammation. Topical formulations are often used for immediate response and effect because they are very strong and provide relief quickly.
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8

Jogdand, Sangita, and Jagruti Bhattacharjee. "Evaluation of analgesic activity of turmeric (Curcuma longa Linn.) in Wister rats." International Journal of Basic & Clinical Pharmacology 6, no. 3 (February 24, 2017): 568. http://dx.doi.org/10.18203/2319-2003.ijbcp20170814.

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Background: NSAIDs like Aspirin etc. are randomly used for mild to severe types of pain but long-term and injudicious use of NSAIDs lead to a number of side effects. The present study is designed for exploring the analgesic potential of Curcuma longa Linn (Turmeric) in albino rats, which may widen the therapeutic horizon for the said agent.Methods: Ethanolic extract of Curcuma longa in the doses 100, 200 and 400mg/kg is given orally to 6 Wister rats against a control of normal saline and a standard using Aspirin (300mg/kg) and the animals were subjected to Eddy’s hot plate test at different time intervals i.e., 30, 60, 90 and 120 minutes after administration of the drugs and the parameters were noted.Results: The analgesic activity of Curcuma longa showed significant (p<0.05) increase in mean basal reaction time in Hot plate method when compared to the control (Normal saline). As the dose of the ethanolic extract of Curcuma longa was gradually increased from 100, 200 and 400mg/kg respectively, the analgesic activity significantly increased (<0.05). Effect of curcuma longa at a dose of 400mg/kg is found to be comparable with Aspirin.Conclusions: The results of this study suggest that turmeric (Curcuma longa) has significant analgesic activities in rats.
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9

Savaringal, Jayan Pariyani, and Lally M. S. "Anti inflammatory effect of rhizome of Curcuma longa. Linn, in Albino rats by the method of Carrageenin induced paw oedema." International Journal of Basic & Clinical Pharmacology 7, no. 2 (January 23, 2018): 229. http://dx.doi.org/10.18203/2319-2003.ijbcp20180032.

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Background: Curcuma longa or turmeric is a popular Ayurvedic herb, traditionally used for various inflammatory conditions including rheumatoid arthritis and spondylitis. Turmeric which containing phytochemical ingredient curcumin is used in India for centuries as a topical anti inflammatory agent. Many of the currently used anti inflammatory agents like NSAID’s and glucocorticoids have many undesirable adverse effects, especially when they are used for long period. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-inflammatory effects.Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxlet extraction with 50% ethanol. Albino rats of Wistar strain (170-250grams) obtained from the animal house of medical college Thiruvananthapuram were used. Aspirin was purchased from sigma Labs, Mumbai. Anti-inflammatory effect of the extract was done in rats by the method of Carrageenin induced paw oedema.Results: The ethanolic extract of Curcuma longa inhibited the development of oedema at the end of 3 hours. The anti-inflammatory activity exhibited by the extract was dose dependent and statistically significant at dose levels of 1000-mg/kg and comparable to that of standard drug used Aspirin.Conclusions: The present study with extract of Curcuma longa revealed that it has significant anti-inflammatory activity.
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10

Rahmah, Miftahur, Febrianawati Yusup, and Agustina Ambar Pertiwi. "Validitas Buku Etnobotani Kunyit (Curcuma longa linn.) dalam Pengobatan Tradisional Bapidara." Experiment: Journal of Science Education 3, no. 2 (December 8, 2023): 1–10. http://dx.doi.org/10.18860/experiment.v3i2.23407.

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Validasi diartikan sebagai suatu tindakan pembuktian dengan cara yang sesuai bahwa tiap bahan, proses, prosedur, kegiatan, sistem, mekanisme yang digunakan dalam produksi dan pengawasan akan senantiasa mencapai hasil yang diinginkan. Buku yang divalidasi adalah buku saku etnobotani kunyit (Curcuma longa Linn.) dalam pengobatan tradisional bapidara. Validator terdiri dari 2 orang, yaitu ahli materi dan ahli media. Tujuan penelitian ini adalah untuk mengetahui validitas dari buku saku etnobotani kunyit (Curcuma longa Linn.) dalam pengobatan tradisional bapidara. Adapun hasil yang didapatkan dari uji validasi oleh validator ahli materi dan ahli media buku saku etnobotani kunyit (Curcuma longa Linn.) dalam pengobatan tradisional bapidara adalah valid dengan skor 84,63%, hal ini menunjukkan bahwa buku saku dapat digunakan tetapi perlu revisi kecil. Adapun saran yang dapat diberikan peneliti untuk perbaikan penelitian selanjutnya adalah: (1) buku saku sebaiknya juga dikembangkan pada materi-materi lain, (2) perlu ditambahkannya gambar pada semua sub materi pada buku saku yang telah dikembangkan agar menarik untuk dipelajari.
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11

Muhamed, Intan Athirah, Wan Amir Nizam Wan Ahmad, Nurul Syahida Ramli, and Noraini A. Ghafar. "Antimicrobial and antioxidant property of Curcuma longa Linn." International Journal of Basic & Clinical Pharmacology 8, no. 11 (October 22, 2019): 2383. http://dx.doi.org/10.18203/2319-2003.ijbcp20194772.

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Background: Curcuma longa Linn. (Zingiberaceae family) plant or turmeric is known to possess pharmacological properties at relatively nontoxic doses. The study was carried out with the aim to evaluate the antimicrobial and antioxidant activities of C. longa L.Methods: Ethanolic rhizome extract was applied against Staphylococcus aureus and Salmonella typhi using disc and well diffusion methods. Antioxidant of C. longa L. was determined by measuring 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.Results: The ethanolic extract of rhizomes showed inhibitory activity against Gram-positive S. aureus bacteria, whereas the Gram-negative S. typhi bacteria were resistant toward the ethanol extract. Zone of inhibitions against S. aureus were 7 mm and 11 mm by disc and well method, respectively. For antioxidant activity, DPPH radical scavenging activity of ethanolic extract of C. longa L. was set against butylated hydroxytoluene (BHT). It was shown that the value of half maximal inhibitory concentration (IC50) of rhizome extract was higher than standard control. The dose response curve was utilized to determine the half maximal IC50 value for each sample. The IC50 of rhizome extract is 21.25 µg/ml, while the value IC50 for BHT is 12.42 µg/ml.Conclusions: The finding suggested turmeric rhizome-extract as a good candidate in the search for a natural antimicrobial and antioxidant agent.
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12

Nitin S Kunnoor, Basavambika Anandi, Komal Halkai, and Priyanka K. "Efficacy of long term administration of curcuma longa linn. on learning and retention memory in albino mice." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 21, 2020): 2955–59. http://dx.doi.org/10.26452/ijrps.v11ispl4.4587.

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There is an increase in non-degenerative memory-related disorders in elderly people. Curcuma Longa linn. can induce cognitive improvement by reducing oxidative stress and antioxidant property. This study evaluated the effect of chronic administration of Curcuma Longa linn. on learning and memory in mice. Twenty four male swiss albino mice aged 6 to 8 weeks, weighing 25-30 g were randomized into control, standard, and test groups. Control group received 0.5% Carboxymethylcellulose; the standard group received piracetam and test group received Curcuma Longa linn. orally for 42 days (6 weeks). Water maze test and step-through passive avoidance test were used to evaluate the effect of Curcuma Longa linn. on learning and memory. 1 week of water maze training done (day 40 to 46). On day 47, spatial memory assessment was done. On day 49 retention memory assessment was done. In control, tandard, and test groups, the mean escape latency (EL) was observed to be 42.7, 30.7, and 31.3 seconds on day 43 which decreased to 11.3, 11.6, and 9.8 seconds on 46th day, respectively. The EL in all the three groups decreased from day 43 to Day 46 (p<0.01). The time spent in the northeast target quadrant was more in the test group (21.6 seconds) compared to control (19.9 seconds) and standard group (19.6 seconds) (p=0.768). Test group showed a trend towards improvement in retention memory (p=0.293) in passive avoidance test. In conclusion, Curcuma Longa linn. demonstrated that long term administration may be useful in enhancing the learning in albino mice but there was no improvement in retention of memory in test group mice as compared to the standard and controlled animals.
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13

Suryani, Novia, Faradillah Munawar, and Siti Hajaroh. "Phytochemical Screening of Active Secondary Metabolites and Antibacterial Activity Kaffir Lime Leaf (Citrus hystrix) and Tumeric Leaf (Curcuma longa Linn.) Against Escherichia coli." ALKIMIA : Jurnal Ilmu Kimia dan Terapan 5, no. 2 (February 28, 2022): 150–58. http://dx.doi.org/10.19109/alkimia.v5i2.11264.

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This study aims to determine the content of active compounds of secondary metabolites and antibacterial activity of secondary metabolites from a maceration of turmeric leaf (Curcuma longa Linn.) and kaffir lime leaf (Citrus hystrix) against Escherichia coli (E. coli). Each sample of kaffir lime leaf and turmeric leaf was extracted by maceration method using 96% ethanol solvent for 3 x 24 hours and the solvent was changed every 1 x 24 hours, then the filtered filtrate was thickened using a rotary evaporator. The phytochemical screening test was carried out by qualitative method using chemical reagents. The antibacterial activity test of the extract of the combination of turmeric leaves (Curcuma longa Linn.) and kaffir lime leaves (Citrus hystrix) used the Punch Hole Diffusion method with various concentrations of 20%, 40%, 60%, 80%, and 100%. The results showed that the combined extract of turmeric leaf (Curcuma longa Linn.) and kaffir lime leaf (Citrus hystrix) contained secondary metabolites in the form of flavonoids, alkaloids, steroids, tannins, and saponins. The optimum zone of inhibition to inhibit the growth of E. coli produced was 9.73 ± 0.78 mm. Overall, it can be concluded that the combined extract of turmeric leaf (Curcuma longa Linn.) and kaffir lime leaf (Citrus hystrix) has potential as an alternative to antibacterial active compounds.
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Rini, Chylen Setiyo, Jamilatur Rohmah, and Leni Yuroh Widyaningrum. "Efektivitas Kunyit (Curcuma longa Linn) terhadap Esherichia coli dan Bacillus subtilis." Medicra (Journal of Medical Laboratory Science/Technology) 1, no. 1 (July 25, 2018): 1. http://dx.doi.org/10.21070/medicra.v1i1.1546.

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Herbal plants that serve as a drug, one of which is turmeric that has a role as an antioxidant, antimicrobial, anti-cancer, digestive disorders. Because it contains compounds curcumin and essential oils. The purpose of this research is to know the optimal concentration of dry extract of turmeric rhizome (Curcuma longa L) in inhibiting the growth of E. coli and Bacillus subtilis. This research method using diffusion agar Kirby Bauer. In this study, turmeric extract at 15% concentration had antibacterial efficacy against Bacillus subtilis (0,7 mm) greater than Escherichia coli (0,63 mm).
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15

Bordoloi, Purnima, and Mangala Lahkar. "Evaluation of Curcuma longa Linn. for hypolipidaemic effects." Journal of Ayurvedic and Herbal Medicine 2, no. 4 (August 25, 2016): 131–35. http://dx.doi.org/10.31254/jahm.2016.2408.

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Ethanolic extracts of Curcuma longa Linn. (CLL) was evaluated for the hypolipidaemic effects in atherogenic diet fed rabbits and compared with a standard hyoplipidaemic drug lovastatin. Animals under atherogenic diet only, showed significantly raised serum cholesterol, triglycerides, VLDL and LDL levels at the 4th and 16th week of study. There was significant decrease in HDL level at 16th week of study. CLL administration at doses of 1.6 mg/kg/day and 3.2 mg/kg/day along with atherogenic diet significantly decreased all the lipid parameters except HDL at 4th and 16th week. The levels were 38.8 ± 3.06, 39.3 ± 2.16, 7.86 ± 0.43 and 9.3 ± 3.76 respectively for 1.6 mg/kg/day dose and 38.5 ± 2.25, 41.6 ± 3.32, 8.33 ± 0.66 and 6.33 ± 1.58 for 3.2 mg/kg/day dose respectively at 4th week.At 16 weeks, the lipid levels were found to be 37.6 ± 2.54, 37.6 ± 2.06, 7.53 ± 0.41 and 6.46 ± 3.06 respectively at 1.6 mg/kg/day dose and 37.5 ± 1.87, 37.5 ± 1.87, 7.5 ± 0.37 and7.16 ± 2.13 respectively at 3.2 mg/kg/day dose of CLL. Lovastatin also reduced all the above lipid parameters except HDL at 4th week and 16th week. The HDL levels in all the groups of animals under CLL as well as lovastatin increased in 4th week and it was significantly increased at 16th week. The reduction in lipid parameters of both the test doses of CLL was comparable with that of lovastatin.
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16

Mubarak, Zaki, Basri A. Gani, and Mutia. "DAYA HAMBAT KUNYIT (Curcuma longa linn) TERHADAP PERTUMBUHAN Candida albicans." Cakradonya Dental Journal 11, no. 1 (May 9, 2019): 1–7. http://dx.doi.org/10.24815/cdj.v11i1.13621.

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Kunyit (Curcuma longa linn) merupakan bahan herbal mengandung senyawa aktif Curcuminoid yangterdiri atas Curcumin, Bisdementhoxycurcumin dan Dementhoxycurcumin yang mempunyai sifat antijamur. Tujuan penelitian ini adalah untuk menganalisis daya hambat ekstrak kunyit terhadappertumbuhan Candida albicans, in vitro. Uji daya hambat pada penelitian ini menggunakan metodedifusi agar (Kirby-Bauer) dengan nistatin 100μg sebagai kontrol positif dan kertas cakram kosongsebagai kontrol negatif. Data dianalisis dengan menggunakan ANOVA satu arah (One Way Analysisof Varians) dengan taraf kepercayaan 5%, kemudian dilanjutkan dengan uji Duncan. Hasil penelitianmenunjukkan bahwa ekstrak kunyit dengan pelarut etanol 96% pada konsentrasi 12,5%, 25%, 50%,75% dan 100% dapat menghambat pertumbuhan C.albicans. Diameter zona hambat terbesar terlihatpada konsentrasi ekstrak kunyit 100% yaitu 10,3 mm, dan diameter terkecil terlihat pada konsentrasi12,5% yaitu 6,6 mm. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak kunyit dapatmenghambat pertumbuhan C.albicans, dengan demikian berpotensi untuk digunakan sebgai bahanherbal anti-C.albicans. Namun potensi in vivo herbal ini perlu ditetapkan melalui studi lanjut padahewan coba.Kata kunci: Kunyit, Candida albicans, difusi agar
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17

Savaringal, Jayan Pariyani, and Sanalkumar K. B. "Anti-ulcer effect of rhizome of Curcuma longa Linn, by the method of pyloric ligation." International Journal of Basic & Clinical Pharmacology 7, no. 1 (December 23, 2017): 20. http://dx.doi.org/10.18203/2319-2003.ijbcp20175480.

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Background: Substantial part of the world population has been known for a long time to suffer from peptic ulcer disease. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-ulcer properties.Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxhlet extraction with 50% ethanol. Albino rats of Wistar strain (120-200 grams) obtained from the animal house of medical college Thiruvananthapuram were used. Ranitidine was collected from Kerala Sate Drugs and Pharmaceutical LTD Alapuzha. Antiulcer study in rats were done using the method of pyloric ligation.Results: Antiulcer study in rats using the method of pyloric ligation, extract of Curcuma longa in 1000mg/Kg dose levels exhibited significant protection against shay ulceration. The results were comparable to that of standard drug Ranitidine.Conclusions: The present study with extract of Curcuma longa revealed that it has significant anti-ulcer activity.
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18

Shreedevi H. Huddar, Anupkumar E., and Anil Jadhav. "Classical review of Haridra (Curcuma longa)." Journal of Ayurveda and Integrated Medical Sciences 8, no. 4 (May 25, 2023): 122–27. http://dx.doi.org/10.21760/jaims.8.4.21.

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Haridra (Curcuma Longa Linn.) is one of the patent drug of India and the most valuable drug which is used by the Indians in all the ways for the rituals (in marriages & poojas); for preparing food preparation and as usual as home remedy medicine since ancient days. Till today Haridra is considered to be the most important drug. The aim of this study is to collect and evaluate the information on Haridra an important valuable medicinal plant and is mentioned in different Ayurvedic treatises like Brihadtrayee, Lagutrayee, and Nigantus. It is a drug which is having high therapeutic value as the root is available both in dried and wet form and this is used in so many preparations and used as Ekamuliya Prayoga (single drug therapy) also and is having highly antimicrobial and anti-fungal and anti-bacterial activity.
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19

Suryawanshi, Sampat, and Pramod Kulkarni. "THEORETICAL VALIDATION OF MEDICINAL PROPERTIES OF Curcuma longa Linn." Rasayan Journal of chemistry 13, no. 01 (2020): 245–48. http://dx.doi.org/10.31788/rjc.2020.1315581.

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20

Marennavar, Santosh, Sakshi Shahapurmath, Shafin Paneri, Tanvi Nayak, Akshay K. Patil, and Sunil S. Jalalpure. "Incorporation of standardised extract of Curcuma longa Linn into phytosomes and its evaluation for in vitro Anti-inflammatory potential and Brine shrimp lethality assay." International Journal of Ayurvedic Medicine 15, no. 1 (April 1, 2024): 111–16. http://dx.doi.org/10.47552/ijam.v15i1.4188.

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Aim: To incorporate standardized Curcuma longa Linn extract into phytosomes and evaluate for in vitro anti-inflammatory and BSL bioassay. Method: The quality of the plant material was determined by various pharmacognostic parameters. The plant material was then subjected to maceration for extraction using ethanol: water as solvent followed by Soxhlet extraction. The resulting extract was subjected to phytochemical analysis to determine the presence of plant metabolites. The drug and excipients compatibility was evaluated by FTIR study. Furthermore, using the thin film hydration approach, a new lipid-based phytosome was prepared. In vitro anti-inflammatory and brine shrimp lethality tests were performed on prepared phytosome. Results: Moisture content, total ash, acid insoluble ash, water soluble ash values, aqueous, alcohol, and petroleum ether extractive values are all found to be within limits. The phytochemical analysis validated the existence of alkaloids, tannins, resins, carbohydrates, proteins, flavonoids, and saponins. The compatibility study demonstrates the compatibility of excipients with drugs. Thin film hydration technique was employed successfully to prepare the phytosomes containing Curcuma longa linn extract. In vitro anti-inflammatory activity revealed that prepared phytosome could serve as natural based therapeutic option for anti-inflammatory potential. Brine shrimp lethality assay also confirmed the bioactivity of prepared phytosomes. Conclusion: The method used for standardization can be used to aid with plant identification and quality analysis of Curcuma longa Linn for future research. It can be inferred from the findings that phytosomes loaded with Curcuma longa Linn extract exhibited promising anti-inflammatory and cytotoxic effects.
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Santos, Vítor Emanuel Andrade dos, Ana Vitória Soares da Silva Carvalho, Maria Eduarda Santos Rodrigues, Maria Eduarda Silva Moreira, and Cristiane Metzker. "USO DA CURCUMA LONGA LINN NO TRATAMENTO DA ARTRITE REUMATOIDE." Revista Ibero-Americana de Humanidades, Ciências e Educação 9, no. 10 (November 14, 2023): 2759–69. http://dx.doi.org/10.51891/rease.v9i10.11524.

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A artrite reumatoide (AR) é uma doença autoimune crônica e progressiva caracterizada por inflamação persistente nas articulações periféricas. Sua etiologia é complexa, envolvendo fatores genéticos, ambientais, hormonais e manifestações extra intestinais. A doença causa inflamação simétrica nas articulações, especialmente nas mãos e nos pés, levando à tumefação, edema, dor e, se não tratada adequadamente, à destruição permanente das articulações. A AR afeta aproximadamente 0,5% a 1% da população e tem um impacto significativo na qualidade de vida e na economia. O tratamento da AR envolve educação do paciente, medicamentos, fisioterapia, apoio psicossocial, terapia ocupacional e, em alguns casos, cirurgias. Com o avanço da tecnologia, novas abordagens terapêuticas têm sido desenvolvidas para controlar a doença, incluindo o uso de fitoterapia. A Curcuma longa, também conhecida como cúrcuma, tem sido estudada devido às suas propriedades anti-inflamatórias e antioxidantes. Originária do Sudeste Asiático, a cúrcuma é utilizada como tempero, corante e na medicina tradicional. O tratamento da AR envolve educação do paciente, medicamentos, fisioterapia, apoio psicossocial, terapia ocupacional e, em alguns casos, cirurgias. Com o avanço da tecnologia, novas abordagens terapêuticas têm sido desenvolvidas para controlar a doença, incluindo o uso de fitoterapia. A Curcuma longa, também conhecida como cúrcuma, tem sido estudada devido às suas propriedades anti-inflamatórias e antioxidantes. Originária do Sudeste Asiático, a cúrcuma é utilizada como tempero, corante e na medicina tradicional. Palavras-chave: Artrite reumatoide, inflamação articular, fitoterapia, Curcuma longa, tratamento adjuvante.
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Yuditha, Solva, Aulia Esa Rafana, and Lukas Kusparmanto. "POTENTIAL INHIBITORY POWER OF "CURCUMA LONGA LINN." EXTRACT AGAINST CANDIDA ALBICANS FUNGUS." Moestopo International Review on Social, Humanities, and Sciences 2, no. 2 (October 31, 2022): 120–26. http://dx.doi.org/10.32509/mirshus.v2i2.39.

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Oral candidiasis is a fungal infection that often appears on the oral mucosa. These lesions are caused by the fungus Candida albicans. Candida albicans is the most common pathogenic Candida species causing fungal infections of the oral cavity. The use of antifungal drugs is the most common way of giving, but there are many side effects that can be caused. Herbal ingredients that have antifungal effects can be alternative therapies with fewer side effects, one of which is turmeric (Curcuma longa Linn.). Turmeric has various compounds that have the potential as antifungals including curcumin, flavonoids, and essential oils that work by inhibiting the growth of fungi including Candida albicans. The purpose of this literature study is to provide scientific evidence related to the potential inhibition of turmeric extract (Curcuma longa Linn.) against Candida albicans. This writing is a literature study made based on reference sources or references obtained from journals accessed through the databases of Google Scholar, Hindawi, PubMed, Scopus, DOAJ, Research Gate and textbooks. The results of the study stated that turmeric extract had an inhibitory effect on the growth of Candida albicans, the greater the concentration of turmeric extract used, the greater the inhibition caused. Turmeric also has fewer side effects than antifungal drugs.
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Ansari, Mohd Masihuzzaman, and Younis I. Munshi. "HALDI (CURCUMA LONGA LINN.) AN IMPORTANT AND EFFECTIVE HOME REMEDY: A REVIEW." Indian Journal of Unani Medicine 15, no. 01 (2022): 51–55. http://dx.doi.org/10.53390/ijum.2022.15109.

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Haldi (Curcuma longa) is an important and famous home remedy which is available almost in every kitchen. Since long times it has been used by Unani and Ayurvedic Physicians due to its Mohallil-e-Warm (Anti-inflammatory), Musakkin-e-Auja (Analgesic), Muhsin-e-Laun (Cosmetic) and Jaali (Detergent) properties. Recent studies have shown that Curcuma has also many important pharmacological properties like Hepatoprotective, Renoprotective, Anti-cancerous, Anti-oxidant, Antibacterial, Anti-fungal etc. Keeping this view its use and importance is highlighted.
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Firman, Gelline Tama Anindia, Min Rahminiwati, and Ike Yulia Wiendarlina. "AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK AIR PEGAGAN (Centella asiatica L. Urban) DAN EKSTRAK ETANOL KUNYIT (Curcuma longa Linn) TERHADAP TIKUS PUTIH JANTAN SPRAGUE DAWLEY." FITOFARMAKA: Jurnal Ilmiah Farmasi 7, no. 1 (June 1, 2017): 13–28. http://dx.doi.org/10.33751/jf.v7i1.797.

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ABSTRAKHepatoproktektor adalah senyawa yang dapat mencegah dan memperbaiki sel-sel hepar yang rusak. Parameter yang diamati adalah perubahan kadar SGPT pada hari ke 0,2, 5, 9 dan 13. Hasil penelitian dari 9 kombinasi dosis selama 13 hari menunjukkan semua kombinasi menurunkan kadar SGPT dengan aktivitas hepatoprotektor terbaik adalah terdapat pada tumbuhan ektrak air pegagan: ekstrak etanol kunyit dengan perbandingan 2:3.Kata kunci: Pegagan (Centella asiatica L.Urban), Kunyit (Curcuma longa Linn) dan hepatoprotektorABSTRACTHepatoprotector is a compound that can prevent and repair liver cell damage. This research aimed to study the activity and effectivity of combination Centella asiatica water extract and Curcuma longa ethanol extract as hepatoprotector by SGPT (Serum Glutamat Piruvat Transaminase) in Sprague Dawley male white rats induced paracetamol. Parameters measured were changes in ALT levels at day 0, 2, 5, 9 and 13. Combinations of doses for 13 days showed all combinations of those extract potencial hepatoprotector. The best activity was found in ratio 2:3 (Centella asiatica extract:ethanol extract of turmeric).Keywords: Centella asiatica L. Urban, Curcuma longa Linn and Hepatoprotector
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Baizuroh, Ning, Yahdi Yahdi, and Yuli Kusuma Dewi. "Uji Kualitas Hand Sanitizer Ekstrak Daun Kunyit (Curcuma Longa Linn)." al-Kimiya 7, no. 2 (December 31, 2020): 88–94. http://dx.doi.org/10.15575/ak.v7i2.8744.

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Diare merupakan penyakit yang diakibatkan oleh berbagai jenis bakteri salah satunya bakteri Escherichia coli dan Staphylococcus aureus. Hand sanitizer merupakan antiseptik yang dapat membunuh bakteri karena mengandung alkohol dan triklosan. Selain itu, daun kunyit mempunyai senyawa metabolit sekunder seperti flavonoid, terpenoid, triterpenoid tanin, dan saponin, yang berperan sebagai antibakteri. Hand sanitizer ekstrak daun kunyit dibuat dengan cara memberikan variasi volume pada ekstrak daun kunyit sebanyak 0 mL, 5 mL, 10 mL, 15 mL, dan 20 mL, kemudian di uji dengan uii organoleptik, uji viskositas, uji pH dan uji antibakteri. Pada pengujian organoleptik berupa warna, aroma, dan tekstur mendapatkan hasil tertinggi berturut-turut pada ekstrak daun kunyit 10 mL, 10 mL, dan 5 mL. Adapun nilai terendah pada uji organoleptik (warna, aroma, tekstur) berturut-turut ekstrak daun kunyit 20 mL, 0 mL, 0 mL. Uji viskositas paling tinggi pada formulasi 1 (0 mL) dan terendah pada formulasi 5 (20 mL). selanjutnya uji pH menunjukkaan formulasi paling tinggi berada pada formulasi 1 (0 mL) dan 5 (20 mL), terendah pada formulasi 3 (10 mL). Adapun pada uji antibakteri, hand sanitizer ekstrak daun kunyit meunjukkan zona hambat paling besar pada bakteri Staphylococcus aureus dan Escherichia coli. Formulasi terbaik pada kualitas hand sanitizer ekstrak daun kunyit berdasarkan semua jenis uji berturut-turut adalah formulasi 4 (15 mL), formulasi 3 (10 mL), formulasi 2 (5 mL), formulasi 1 (0 mL) dan kualitas terendah hand sanitizer ekstrak daun kunyit adalah formulasi 5 (20 mL). Kata Kunci: Hand sanitizer; ekstrak daun curcuma longa linn; escherichia coli; staphylococcus aureus.
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Verma, Krishna Kumar, Shristi Soni, Pratiksha Pandey, Varsha Sahu, Sumit Kumar Dubey, and Neha Behar. "Comparative Evaluation of In Vitro Antimicrobial Efficacy of different Species of Curcuma against Human Pathogenic Bacteria." NewBioWorld 5, no. 1 (June 5, 2023): 20–23. http://dx.doi.org/10.52228/nbw-jaab.2023-5-1-4.

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Herbal medicines have been commonly used for the treatment and prevention of disease, health promotion and for the enhancement of the life span. The Curcuma species viz., C. Roxb., C. longa Linn and C. amada are used as medicine in traditional therapeutic practices. The remedy for various diseases including cough, diabetes and hepatic disorders. The efficiency of turmeric fractions, such as petroleum ether, chloroform, benzene, methanol and aqueous were evaluated for their inhibitory effect on clinical and standard strains of pathogenic bacteria. The methanolic fraction of Curcuma longa rhizome had high potential to inhibit some pathogenic bacteria i.e. S. aureus to a greater degree than other fractions of Curcuma longa. In our study the results show that the different fractions (petroleum ether, methanol etc.) of Curcuma caesia rhizome were more effective antimicrobial agents than the crude extract of Curcuma longa. The bacteria isolates include E. coli (MTCC 443), Pseudomonas aeruginosa (MTCC 424), and Staphylococcus aureus (MTCC96) Antimicrobial activities were estimated by Disc diffusion method. The results were pointed as the methanol, acetone and petroleum ether, extract was more effective on all three pathogenic bacteria.
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Aseptianova, Aseptianova. "PENGARUH EKSTRAK DAUN KUNYIT (Curcuma longa Linn.) SEBAGAI INSEKTISIDA ELEKTRIK TERHADAP MORTALITAS NYAMUK Culex sp. L." Pro-Life 6, no. 1 (March 5, 2019): 44. http://dx.doi.org/10.33541/pro-life.v6i1.937.

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Mosquito Culex sp. L. is a vector of elephantiasis disease, prevention effort of elephantiasis vector is usually done by using chemical and natural insecticide. In the leaves of turmeric can be used as a natural insecticide in the prevention of elephantiasis vector disease. The objectives of this research are (1) to know the effect of turmeric extract ((Curcuma longa Linn.) As electrical insecticide to mortality of Culex sp. L. (2) To know the concentration of turmeric extract (Curcuma longa Linn.) Which is effective to be used as an electric insecticide against mortality of Culex sp. L. expressed by the toxicity test of LC50 and LT50. The method used in this research is an experimental method with Completely Randomized Design (RAL) which consists of 5 treatments and 4 replications. Based on research result of turmeric extract (Curcuma longa Linn.) Have a very significant effect on mortality of Culex sp. L. with sig value 0,000 <sig value. 0.05. The probit analysis of LC50 of turmeric leaves extract on mortality of Culex sp. L. is 44, 840 ml, meaning that at that concentration has occurred 50% mortality of total mosquito. The probit analysis of LT50 turmeric leaves extract on mortality of Culex sp. L. for 1.825 hours. Keywords: turmeric leaves extract, mortality Culex sp. L. mosquito
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Lwin, Khin Myat, Hla Myat Mon, and Khin Htay Myint. "Evaluation of the antimalarial activity of Curcuma longa Linn., singly and in combination with Eupatorium odoratum Linn." Journal of Ayurvedic and Herbal Medicine 3, no. 1 (March 30, 2017): 11–14. http://dx.doi.org/10.31254/jahm.2017.3103.

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Following the observation of in vitro anti-malarial activity of the ethanolic extract of Curcuma longa Linn., the active compound was isolated from its rhizome and detected in vitro, the results showed that schizont suppression of 62.63% even at the lowest concentration 0.625 µg/ml on human malaria with IC50 values of <0.625ug/ml. Another test sample extract of Eupatorium odoratum Linn, revealed that the significant antimalarial activity with IC50 value of 0.8581 ug/ml. The combination of C. longa and E. odoratum was found to be IC50 of <0.625 µg/ml showing their probable synergistic effect on the human malaria parasite. The extract and isolated compound of C. longa was further tested for their antimalarial activity using Plasmodium berghei mouse model. The highest in vivo parasite suppression was found to be 67.9% and 72.97% at the dosage of 50 mg/kg body weight for C. longa extract and isolated compound respectively. Moreover, brine shrimp toxicity test and in vivo toxicity test in mice showed no lethal effect of both C. longa and E. odoratum at the tested concentration which is moderately high. The results showed that both plant samples are potentially safe and possess prospective anti-malarial activity. It can be used as a single or combination.
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Aprilia, Vina, Asti Meizarini, and Titien Hary Agustantina. "Sitotoksisitas Kombinasi Seng-oksida dan Ekstrak Curcuma longa Terhadap Fibroblas Gingiva Manusia." Jurnal Material Kedokteran Gigi 8, no. 1 (March 1, 2019): 1. http://dx.doi.org/10.32793/jmkg.v8i1.335.

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The use of zinc oxide - eugenol as periodontal dressing is controversial due to the toxic nature of eugenol and Curcuma longa Linn as a safe natural herbal, is expected to replace eugenol function. Previous research has proven that the combination of zinc oxide with Curcuma liquid extract has an antibacterial properties and the use of those as wound dressing through in vivo studies proved to accelerate wound healing. The ingredients applied to the oral cavity must benon-toxic and biocompatible, therefore cytotoxicity testing 1 is required. To determine the cytotoxicity of zinc oxide and Curcuma longa extract combination on human gingival fibroblast cells. Cytotoxicity test of combination of zinc oxide powder with Curcuma liquid extract was done at ratio of 1: 1 (group A) and 2: 1 (group B), Curcuma liquid extract (group C) and zinc oxide powder (group D), which performed on human gingival fibroblast culture-cells (3-5x103 densities) in 96 wells microplate. MTT essay was used to analyzed with IC50 parameters. Statistical analysis using oneway Anova and LSD. The number of living cells in group A = 64.819%, group B = 59.452%, group C = 52.859% and group D = 60.502%. There was no significant difference between the groups of A, B, D but those groups were significantly different to group C. Combination of zinc oxide with Curcuma extract ratio of 1: 1 and 2: 1, zinc oxide powder and Curcuma liquid extract are not toxic to human gingival fibroblast at IC50.
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Pekasa, Nathaniel Nickander Pramuditha, Fen Tih, and Julia Windy Gunadi. "PENGARUH SEDUHAN RIMPANG KUNYIT KUNING (Curcuma longa Linn.) TERHADAP PEMAHAMAN BACAAN." JURNAL ILMU FAAL OLAHRAGA INDONESIA 4, no. 1 (April 3, 2021): 22. http://dx.doi.org/10.51671/jifo.v4i1.95.

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Increasing globalization makes humans need the knowledge to compete globally. One way to increase knowledge is by reading. Reading comprehension is the process of interpreting a reading in order to gain a thorough knowledge of the passage. Therefore it is necessary to consume beverages to improve energy and cognitive function. In this study, the researcher used yellow turmeric rhizome steeping as an enhancer of cognitive function. The objective of this research was to determine the effect of consuming yellow turmeric rhizome steeping on the cognitive function which is reading comprehension. This study was quasi-experimental, comparative using pretest and post-test design, conducted on 30 men aged between 18-22 years. Participants were asked to do a reading comprehension test (pretest) than consume 200 cc of water mixed with 10 grams of yellow turmeric rhizome powder. Participants took rest for 90 minutes and asked to do a reading comprehension test (post-test). The measured data was the reading comprehension test score, in the form of a correct answer of 10 questions. Data were analyzed using Wilcoxon Signed Rank Test. The average score of correct answers increased very significantly, before consuming yellow turmeric steeping was 47,33 to 73,33 after consuming yellow turmeric rhizome steeping with p < 0,001. Therefore yellow turmeric rhizome steeping increases reading comprehension.
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Goyal, A. K., K. Ganguly, T. Mishra, and Arnab Sen. "In vitro multiplication of Curcuma longa Linn.-an important medicinal zingiber." NBU Journal of Plant Sciences 4, no. 1 (2010): 21–24. http://dx.doi.org/10.55734/nbujps.2010.v04i01.003.

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Curcuma longa Linn. is a herbaceous perennial plant belonging to the family Zingiberaceae. In viro protocol for the regeneration of plantlets from the sprouted rhizomes of turmeric was optimized. Murashige and Skoog media supplemented with different concentrations and combinations of cytokinins and varied percentage of sucrose were experimented. Murashige and Skoog media supplemented with benzyl amino benzene (BAP) at the concentration of 2mg/l and sucrose 3% showed the best regeneration in comparison to Kinetin when used singly. Combination of 2mg/1 BAP and 3mg/ Kinetin resulted in highest number of shoots. The same media showed spontaneous rooting. Healthy regenerated plantlets were selected for hardening in sterile mixture of garden soil and sand in the ratio of 1:1. Ninety three percent of the micropropagated plantlets survived to maturity when transferred to soil.
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Goyal, A. K., K. Ganguly, T. Mishra, and Arnab Sen. "In vitro multiplication of Curcuma longa Linn.-an important medicinal zingiber." NBU Journal of Plant Sciences 4, no. 1 (2010): 21–24. http://dx.doi.org/10.55734/nbujps.2010.v04i01.003.

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Curcuma longa Linn. is a herbaceous perennial plant belonging to the family Zingiberaceae. In viro protocol for the regeneration of plantlets from the sprouted rhizomes of turmeric was optimized. Murashige and Skoog media supplemented with different concentrations and combinations of cytokinins and varied percentage of sucrose were experimented. Murashige and Skoog media supplemented with benzyl amino benzene (BAP) at the concentration of 2mg/l and sucrose 3% showed the best regeneration in comparison to Kinetin when used singly. Combination of 2mg/1 BAP and 3mg/ Kinetin resulted in highest number of shoots. The same media showed spontaneous rooting. Healthy regenerated plantlets were selected for hardening in sterile mixture of garden soil and sand in the ratio of 1:1. Ninety three percent of the micropropagated plantlets survived to maturity when transferred to soil.
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., Nita Dongare, Yogesh Walunj ., and Pramod Kulkarni . "Theoretical Validation of Medicinal Properties of Curcuma longa Linn - Part-2." Journal of Current Pharma Research 9, no. 2 (February 15, 2019): 2752–58. http://dx.doi.org/10.33786/jcpr.2019.v09i02.006.

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Sharma, Anshul, Pankaj Chauhan, Ravindra Kumar, R. S. Sengar, Purushottam, Shalini Gupta, and Neelesh Kapoor. "Phytochemical Studies and Anti-Microbial Activity of Curcuma Longa Linn Rhizomes." Biotech Today : An International Journal of Biological Sciences 10, no. 1 (2020): 39. http://dx.doi.org/10.5958/2322-0996.2020.00001.0.

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Dewi, Itta Sandi Lesmana, Kadek Mercu Narapati Pamungkas, Ida Ayu T. Risha Kundalini, and I. Ketut Mariadi. "POTENSI EKSTRAK DAUN KEMANGI (OCIMUM SANCTUM L.) DAN KUNYIT (CURCUMA LONGA L.) TERHADAP TERAPI KANKER KOLOREKTAL." E-Jurnal Medika Udayana 10, no. 8 (August 30, 2021): 1. http://dx.doi.org/10.24843/mu.2021.v10.i8.p01.

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ABSTRAK Latar Belakang: Kanker kolorektal menduduki posisi ketiga kanker tersering dan posisi keempat kanker yang paling sering menyebabkan kematian diseluruh dunia yaitu sekitar 700.000 kematian setiap tahunnya. Penyakit ini merupakan salah satu keganasan saluran pencernaan yang terbentuk melalui berbagai macam faktor seperti faktor genetik dan lingkungan. Penatalaksanaan kanker kolorektal hingga saat ini dilakukan dengan terapi operasi dan terapi adjuvan yang memiliki banyak efek samping dan mahal bagi sebagian besar orang. Tujuan: Tujuan dibuatnya literature review ini yaitu untuk menemukan modalitas terapi penyakit kanker kolorektal. Metode: Literature review ini disusun menggunakan metode kajian pustaka dengan mengumpulkan sumber dari literatur ilmiah yang valid seperti PubMed dan Google Scholar. Penulis menggunakan kata kunci colorectal cancer, curcumin, Ocimum sanctum L., Curcuma longa Linn., basil, dan tumeric serta logika Boolean “AND” untuk mendapatkan jurnal ilmiah internasional yang spesifik. Pembahasan: Kurkumin dalam Curcuma longa L. dapat menurunkan proliferasi sel kanker kolorektal, merangsang terjadinya apoptosis sel kanker kolorektal, menurunkan metastasis, dan sebagai antiinflamasi. Flavonoid vicenin-2 yang terkandung dalam Ocimum sanctum L. mampu menghambat proliferasi dan menginduksi terjadinya apoptosis sel kanker kolorektal. Zat-zat penting yang terdapat di dalam daun Ocimum sanctum L. diekstraksi melalui beberapa tahapan seperti halnya kurkumin dalam Curcuma longa L. Kesimpulan: Kombinasi ekstrak daun kemangi dan kunyit memiliki potensi sebagai terapi kanker kolorektal. Saran: Penulis menyarankan untuk diadakan penelitan lebih lanjut terkait dosis dan efek samping yang dapat ditimbulkan. Kata kunci : kanker kolorektal., kurkumin., vicenin-2
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Nerkar, Amit Gajanan, Rushikesh Nagarkar, and Shubhangi Badar. "Ethnopharmacological review of turmeric for anticancer activity." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 1 (April 15, 2023): 10–15. http://dx.doi.org/10.18231/j.ctppc.2023.003.

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These reviews suggest that in the Indian subcontinent, turmeric (Curcuma longa Linn) is widely grown and consumed as a spice. Traditional medicine has used turmeric to treat a variety of ailments, such as diabetes, liver disease, and cough. Many studies have been conducted over the past decades to determine the pharmacological effects of turmeric and its derivatives. The main chemical component of turmeric, curcumin, has been shown to have pharmacological properties including anti-inflammatory, antioxidant, anti-mutagenic, antidiabetic, and antibacterial properties., protect liver, expectorant and anti-cancer. Turmeric, also known as Curcuma longa L. (root and rhizome), is a plant of high medicinal and commercial value, mainly used as a spice and food supplement around the world. The three curcuminoids - curcumin (diferuloylmethane, the main ingredient that gives turmeric its yellow color), demethoxycurcumin, and bisdemethoxycurcumin - are the main active ingredients of turmeric. Volatile oils (zingiberene, atlantone, tomerol, etc.) also have pharmacological effects. In addition, turmeric contains proteins, resins and carbohydrates. Turmeric is a powerful antioxidant and has significant anti-inflammatory properties. Turmeric's anti-inflammatory properties may be directly related to its anti-cancer properties. In this review, the anticancer properties of Turmeric have been reviewed.
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叶, 明华. "Study on Protective Mechanism of Curcuma longa Linn on Alcoholic Liver Disease." Advances in Clinical Medicine 11, no. 05 (2021): 2467–73. http://dx.doi.org/10.12677/acm.2021.115355.

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Prabandari, Rani. "Formulasi dan uji stabilitas sediaan lulur dari rimpang kunyit (Curcuma longa linn)." Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan 10, no. 2 (January 7, 2019): 52–58. http://dx.doi.org/10.35960/vm.v10i2.435.

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ABSTRACT Lulur is a type of cosmetics made from flowers and other plant ingredients that are very useful for maintaining beauty, health, smoothness and brightness of the skin of the body. Lulur can help clean the dirt that sticks to the skin due to the influence of weather and pollution factors so that the skin becomes healthy, clean and beautiful. The contents of the substance include turmeric: curcuminoid which consists of curcumin, desmetoksikumin and bisdesmetoksikurkumin and other beneficial substances, such as volatile essential oils of oil, fat, carbohydrates, protein, starch, vitamin C, iron, phosphorus, and calcium. Curcumin is a yellow substance contained by turmeric, on average 10.29%, has broad spectrum biological activity including antihepototoxic, antibacterial and antioxidant so that turmeric is able to be used for traditional medicine both to maintain health and skin beauty of the body, The method used is study experimental scrubs and tested the stability of scrubs containing turmeric rhizome powder. The best scrubs are formula 1 which uses the ratio of turmeric powder to light brown scrub, homogeneous and perfectly fused body scrub, has a pH of 5, spread of 10,321 cm2, has a viscosity consistency of 99,000 mPa.s and adhesion for 4 seconds. Keywords: formulations, scrubs, turmeric.
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Prabandari, Rani. "FORMULASI SEDIAAN LULUR PENCERAH DAN PENGHALUS KULIT DARI KUNYIT (CURCUMA LONGA LINN)." Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan 10, no. 2 (January 7, 2019): 59–67. http://dx.doi.org/10.35960/vm.v10i2.436.

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ABSTRACT Lulur is a type of cosmetics made from flowers and other plant ingredients that are very useful for maintaining beauty, health, smoothness and brightness of the skin of the body. Scrub can help clean the dirt that sticks to the skin due to the influence of weather factors and pollution so that the skin becomes healthy, clean and beautiful. Dry skin types often tend to be more problematic than other skin types. Dry skin is caused by insufficient oil produced by the kelenjer oil, which makes the skin not moist and dry. This can cause skin problems such as: skin looks rough, wrinkled and dull. The contents of the substance include turmeric: curcuminoid which consists of curcumin, desmetoksikumin and bisdesmetoksikurkumin and other beneficial substances, such as volatile essential oils of oil, fat, carbohydrates, protein, starch, vitamin C, iron, phosphorus, and calcium. Curcumin is a yellow substance contained by turmeric, on average 10.29%, has broad spectrum biological activity including antihepototoxic, antibacterial and antioxidant so that turmeric is able to be used for traditional medicine both maintaining health and beauty of the body's skin, the method used to carry out this research is an experiment. The object in this study is the skin of the body found on dry skin in the hands. The sample in this study the author took the students of the University of Harapan Bangsa Purwokerto Pharmacy Department especially women aged 19-25 years, have the same characteristics / criteria that indicated dull, rough and not bright skin. Keywords: formulation, scrub, turmeric, lightening.
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., K. Nasirujjaman, M. Salah Uddin ., S. Zaman ., and M. A. Reza . "Micropropagation of Turmeric (Curcuma longa Linn.) through in vitro Rhizome Bud Culture." Journal of Biological Sciences 5, no. 4 (June 15, 2005): 490–92. http://dx.doi.org/10.3923/jbs.2005.490.492.

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Kim, Hye Jin, Hwa Seung Yoo, Jin Chul Kim, Chan Su Park, Mi Sun Choi, Mijee Kim, Hyangsoon Choi, et al. "Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication." Journal of Ethnopharmacology 124, no. 2 (July 2009): 189–96. http://dx.doi.org/10.1016/j.jep.2009.04.046.

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Kaban, Karmila, and Sunarti Sunarti. "EKSTRAK RIMPANG KUNYIT (Curcuma longa Linn) MENURUNKAN PENYAKIT PERLEMAKAN HATI NON-ALKOHOLIK." BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) 5, no. 2 (January 21, 2019): 123–30. http://dx.doi.org/10.31289/biolink.v5i2.1800.

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The use of recycled frying oil or deep frying oil (DFO) lead to increase in free fatty acid, trans fatty acid and free radical compound. It can cause non-alcoholic fatty liver disease (NAFLD). a chronic liver disease cause the risk for cirrhosis and heart cancer. However, there is no medicine for preventing the disease. The present study was conducted to investigate the turmeric reduces steatosis hepatocyte of male Wistar rat NAFLD model. The study used experimental randomize post-test only control group design. The 24 samples consist of four treatment groups. Group I (control): normal diet + DFO (10 μl/g/day on 6 times heating), Group II, III and IV: normal diet + DFO (10 μl/g/day on 6 times heating)+ turmeric Extract (100, 200, and 400 mg/kg/day) by given for 30 days through oral induction. The results of Kruskal-Wallis test showed a significant difference between the four treatment groups (P= 0.019) .The results of Mann-Whitney test showed significant difference in steatosis hepatocyte between the control group (P1) and treatment group(P3) the dose of 200 mg/kg BW. This suggests that a dose of 200 mg/kg BW is an effective dose in decreasing hepatocyte steatosis.
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43

de Souza, Larissa Marila, Natalia Mayumi Inada, Francine Perri Venturini, Christian C. Carmona-Vargas, Sebastião Pratavieira, Kleber Thiago de Oliveira, Cristina Kurachi, and Vanderlei Salvador Bagnato. "Photolarvicidal effect of curcuminoids from Curcuma longa Linn. against Aedes aegypti larvae." Journal of Asia-Pacific Entomology 22, no. 1 (March 2019): 151–58. http://dx.doi.org/10.1016/j.aspen.2018.12.016.

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44

Cala Delgado, Daniel Leonardo, Andrés Camejo-Hernández, Yudisleivy Hernández-Martínez, Yenyce Montes-Martínez de la Cotera, Olga Lidia González-Barreiro, Claudia Untoria-Gómez, Caridad C. Rodríguez-Torres, María R. Pérez-Capote, Irania Guevara-Orellanes, and Aníbal Domínguez-Odio. "Toxicidad dérmica y oftálmica del extracto hidroalcohólico de Curcuma longa, Linn (Curcuvet)." Spei Domus 18, no. 1 (March 16, 2022): 1–15. http://dx.doi.org/10.16925/2382-4247.2022.01.01.

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Transformar las plantas medicinales en productos industrializables y comercializables implica cumplir numerosas exigencias regulatorias, sobre calidad, seguridad, eficacia y estabilidad de la formulación propuesta. En este contexto, el producto Curcuvet (solución antiséptica y cicatrizante obtenida a partir del extracto hidroalcohólico de C. longa) necesita demostrar su inocuidad antes de utilizarse legalmente en la práctica clínica veterinaria. Por tanto, el presente trabajo tuvo como objetivo evaluar in vivo las potencialidades tóxicas dérmica y oftálmica del producto. Para lograrlo se realizaron tres investigaciones in vivo: toxicidad aguda dérmica, irritabilidad dérmica primaria e irritabilidad oftálmica según las normas descritas por la Organización para la Cooperación Económica y el Desarrollo (OECD) No. 434, 404 y 405 respectivamente. El producto Curcuvet en todos los ensayos fue administrado en dosis única, de forma superficial tanto en piel (rata Sprague Dawley y conejos F1) como en mucosa ocular (conejos albinos Nueva Zelanda). El producto Curcuvet no resultó irritante para la piel de ratas y conejos, no así para las estructuras oculares, las cuales fueron severamente dañadas, alcanzándose un índice de irritabilidad de 110. Se concluye que la formulación Curcuvet administrado en dosis única, resultó no irritante dérmico e irritante severo oftálmico.
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45

Singh, Anupriya, Jyoti Singh, Gangeshwar Kumar Tripathi, Ashwani Kumar, Dev Nath Singh Gautam, and Yuan-Yeu Yau. "Curcuma longa Linn.: A Medicinal Plant with Therapeutic Potential against COVID-19." Journal of Plant Science Research 38, no. 1 (August 2, 2022): 31–63. http://dx.doi.org/10.32381/jpsr.2022.38.01.3.

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46

Sungkar, Mustofa Lukman, Yuni Setyaningsih, Fachri Razi, and Fajriati Zulfa. "Efektivitas ekstrak daun kunyit (Curcuma longa Linn.) sebagai antifungi terhadap Trichophyton rubrum." Health Sciences and Pharmacy Journal 8, no. 1 (April 20, 2024): 31–36. http://dx.doi.org/10.32504/hspj.v8i1.994.

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Trichophyton rubrum, salah satu jamur dermatofita yang umum ditemukan di Indonesia, menghadirkan tantangan besar yang memerlukan solusi efektif. Untuk mengatasi masalah ini, penelitian yang berfokus pada sifat antijamur dari ekstrak daun kunyit (Curcuma longa Linn.) menawarkan potensi yang menjanjikan untuk mengobati infeksi kulit dermatofit. Penelitian ini bertujuan untuk mengkaji efektivitas ekstrak etanol daun kunyit sebagai antijamur terhadap pertumbuhan Trichophyton rubrum secara in-vitro. Menggunakan pendekatan eksperimental dengan desain post-test-only control group, berbagai konsentrasi ekstrak daun kunyit (10%, 20%, 30%, dan 40%) diperiksa bersama kontrol negatif dan positif (aquades dan ketokonazol 2%). Diameter zona hambat pertumbuhan pada media Sabouraud Dextrose Agar diukur dengan menggunakan metode sumur. Analisis menggunakan uji Kruskal-Wallis menunjukkan signifikansi statistik (P <0,05), diikuti dengan uji Post Hoc Mann Whitney. Hasil penelitian menunjukkan potensi penghambatan ekstrak daun kunyit terhadap pertumbuhan jamur, dengan konsentrasi 10%, 20%, dan 30% menunjukkan kekuatan penghambatan ringan, dan 40% menunjukkan kekuatan penghambatan sedang. Variasi hasil dipengaruhi oleh konsentrasi ekstrak dan waktu inkubasi. Khususnya, konsentrasi yang paling efektif adalah 40%, menunjukkan diameter zona hambat berukuran sedang sebesar 8,3625 mm pada 24 jam dan 7,84 mm pada 48 jam, melampaui konsentrasi lainnya. Khasiat ini dapat dikaitkan dengan adanya senyawa seperti alkaloid, flavonoid, saponin, tanin, fenol, dan triterpenoid dalam ekstrak daun kunyit, yang secara kolektif berkontribusi terhadap sifat antijamurnya. Kata kunci: Ekstrak daun kunyit; metode sumuran; Tricophyton rubrum; zona hambat
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47

Concetta Scuto, Maria, Cesare Mancuso, Barbara Tomasello, Maria Laura Ontario, Andrea Cavallaro, Francesco Frasca, Luigi Maiolino, Angela Trovato Salinaro, Edward J. Calabrese, and Vittorio Calabrese. "Curcumin, Hormesis and the Nervous System." Nutrients 11, no. 10 (October 10, 2019): 2417. http://dx.doi.org/10.3390/nu11102417.

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Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.
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Pandey, Jyoti, Suman Mishra, and Kamal Jaiswal. "IN VITRO EVALUATION OF THE ANTHELMINTIC ACTIVITY OF RHIZOME EXTRACTS OF CURCUMA LONGA (LINN.)." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (December 7, 2018): 425. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.28313.

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Objective: The current study was carried out to evaluate the anthelmintic activity of the rhizome extract of Curcuma longa as an alternative source of effective remedies for nematodiasis.Methods: The anthelmintic activity of the C. longa was assessed in vitro against Haemonchus spp., a gastrointestinal (abomasum) parasite of goats. Different concentrations of the extracts (1 mg/mL, 2.5 mg/mL, 5 mg/mL, and 10 mg/mL) in phosphate-buffered saline (PBS) were tested, and the results expressed in terms of time of paralysis (minute) and time of death (minute) of the worms. Albendazole (1 mg/mL) was used as a reference (positive control) and PBS as a control group (negative control).Results: The qualitative phytochemical analysis of the methanolic extract (ME) of the plant disclosed the presence of alkaloids, glycosides, terpenoids, flavonoids, tannins, saponins, phenol, anthraquinone, and carbohydrates; whereas, the aqueous extract (AE) showed the presence of alkaloids, carbohydrate, flavonoids, and saponins. Both ME and AE of the C. longa (rhizome) expressed significant efficacy (p≤0.05) in causing paralysis as well as the death of the worms within 12 h of exposure at all tested concentrations, as compared to the negative control. The rhizome extracts of C. longa showed dose-dependent efficacy in causing paralysis of the worm motility and the final progression to death. The results showed that the ME at 10 mg/mL was significantly more potent (p≤0.05) over the AE.Conclusions: This study concluded that the rhizome extract of C. longa exhibited potent anthelmintic efficacy against the nematode parasite, Haemonchus spp.
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Mhillaj, Emanuela, Andrea Tarozzi, Letizia Pruccoli, Vincenzo Cuomo, Luigia Trabace, and Cesare Mancuso. "Curcumin and Heme Oxygenase: Neuroprotection and Beyond." International Journal of Molecular Sciences 20, no. 10 (May 16, 2019): 2419. http://dx.doi.org/10.3390/ijms20102419.

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Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti-inflammatory pathways involved in neurodegeneration. Although its poor systemic bioavailability after oral administration and low plasma concentrations represent restrictive factors for curcumin therapeutic efficacy, innovative delivery formulations have been developed in order to overwhelm these limitations. This review provides a summary of the main findings involving the heme oxygenase/biliverdin reductase system as a valid target in mediating the potential neuroprotective properties of curcumin. Furthermore, pharmacokinetic properties and concerns about curcumin’s safety profile have been addressed.
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50

Putri, Dyah Ayu Rhomandhoni, Ario Imandiri, and Rakhmawati Rakhmawati. "THERAPY LOW BACK PAIN WITH SWEDISH MASSAGE, ACUPRESSURE AND TURMERIC." Journal of Vocational Health Studies 4, no. 1 (July 31, 2020): 29. http://dx.doi.org/10.20473/jvhs.v4.i1.2020.29-34.

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Background: Low back pain is pain that arises below the costal margin and above the inferior gluteal fold. In Traditional Chinese Medicine (TCM) low back pain is referred to as Yao Tong. Low back pain cases experienced by patients are pain that gets worse when exposed to cold air, is too tired and feels stiff and heavy. The patient has low back pain with damp cold pathogenic syndrome. Purpose: To prove the effect of combination therapy for Swedish massage in the back and waist area, acupressure at Shenshu (BL23), Dachangshu (BL25), Taixi (KI3), Taibai (SP3), Fenglong (ST40) and turmeric herbs (Curcuma longa Linn) on low back pain sufferers. Methods: Management of low back pain with Swedish, acupressure and herbal massage methods. Swedish massage therapy is performed on the back and waist area. Acupressure at the points of Shenshu (BL23), Dachangshu (BL25), Taixi (KI3), Taibai (SP3), Fenglong (ST40) with the principle of therapy of kidney and spleen tonification and elimination of cold moist pathogens. The most common herbal therapy for patients is turmeric (Curcuma longa Linn). Results: The curcumin compounds in turmeric can inhibit lipoxygenase, phospholipase A2 and COX-2 so they can reduce low back pain. In the treatment of low back pain, massage and acupressure are performed 2 times a week 12 times. While herbal therapy is given for 42 days taken once a day with a dose of 9 grams of turmeric simplicia. Conlussion: Swedish massage therapy, acupressure and herbs can reduce low back pain.
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