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Hyun, Yongho, and n/a. "Consumer behaviour on the internet : a critical analysis of the extensive decision-making process of online holiday travellers." University of Canberra. Communication & Education, 2002. http://erl.canberra.edu.au./public/adt-AUC20060801.130043.
Full textAbstract:
Both tourism destination marketing and the characteristics of holiday travellers have
recently undergone radical changes driven by the rapid progress of computer technology. In
particular, the advent of the Internet has had a great impact on holiday travellers as well as
on the development of tourism promotion and distribution channel strategies.
While holiday travellers benefit from the characteristics of Internet use, for example,
unlimited information retrieval, flexible accessibility, and direct interactivity with
destination marketing organizations (DMOs), the Internet provides DMOs with the critical
factor of an increase in operational costs incurred by running all possible online promotional
activities and online distribution channels.
This paper attempted to discover which Internet functions are popularly used by
existing/potential online travellers or which ones are not by testing the Canberra Tourism & Event Corporation (CTEC) web site. As a result, this research intends to provide CTEC with
a way to operate its website cost-effectively, which can also lead to increasing the usage
satisfaction of CTEC web visitors. Online travellers visiting the CTEC website were
surveyed through non-probability self-selected web survey by using segmentation procedure;
two key online travel groups: direct and indirect online access groups.
Based on the research methodology, this study has discovered several findings. Firstly,
CTEC web visitors preferred to use the CTEC website for the purpose of gathering travel
information rather than that of online booking or reservations for travel products on the
CTEC website. Secondly, comprehensive travel information tailor-made to online
individuals was found to be desirable through interactive online activities, while the
multimedia, booking, and comparability function were not significant in helping the CTEC
online visitors choose the travel destination. Based on their preferences for particular
Internet functions, it is evident that web visitors wish to have comprehensive and tailormade
online travel information and interaction with the CTEC. Finally, it was revealed that
the demographics of the CTEC web visitors were very similar to Internet users identified by
previous researchers. Therefore, this study provides insights into website development
strategies.
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Ribeiro, Ot?vio Augusto Silva. "Bebida l?ctea fermentada elaborada com Camellia sinensis." UFVJM, 2013. http://acervo.ufvjm.edu.br:8080/jspui/handle/1/401.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
A presente pesquisa foi conduzida com o objetivo de se desenvolver e caracterizar bebida l?ctea fermentada formulada com Camellia sinensis. Procedeu-se a elabora??o da infus?o de folhas desidratadas e picadas de C. sinensis em soro l?cteo (1g.100g-1) a qual foi adicionada em leite ado?ado (sacarose 10% p/p), coagulado por Streptococcus salivarius subsp. thermophilus e Lactobacillus delbrueckii subsp. bulgaricus nas propor??es de 10, 20, 30 e 40% (v/p). O controle consistiu em iogurte adicionado com sacarose (10% p/p). Procedeu-se ?s determina??es de massa seca, umidade, res?duo mineral fixo, prote?na, gordura, s?dio, acidez, quantifica??o de bact?rias l?ticas totais, atividade antioxidante total e viscosidade no tempo inicial de fabrica??o e em 15 e 30 dias de armazenamento. No produto, em seu tempo inicial de fabrica??o, procedeu-se a determina??o cromatogr?fica de compostos vol?teis e ? condu??o dos testes sensoriais de aceita??o e inten??o de consumo. O teor de massa seca, a umidade, res?duo mineral fixo e contagem total de bact?rias l?ticas de formula??es de bebida l?ctea fermentada n?o foram significativamente afetados pela quantidade de infus?o de C. sinensis adicionada. Entretanto, o conte?do de prote?na, gordura e s?dio foram significativamente menores, quanto maior a percentagem de infus?o incorporada ao produto. Houve redu??o significativa na viscosidade aparente do produto mediante o aumento da quantidade de infus?o adicionada. A atividade antioxidante total das formula??es foi significativamente maior quanto maior a quantidade de infus?o adicionada. A adi??o de infus?o contribuiu para a diversifica??o de compostos vol?teis formadores de aroma e sabor no produto. A formula??o de bebida l?ctea fermentada, com adi??o de 30% de infus?o de C. sinensis em soro l?cteo, foi a preferida em testes sensoriais, com maior aceita??o e maior inten??o de consumo.
Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Zootecnia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2013.
ABSTRACT The aim of this research was to develop and to characterize fermented dairy beverage formulated with Camellia sinensis. Infusion was elaborated with the addiction of dehydrated leaves of C. sinensis in whey (1g.100g-1) which added in sweetened milk (10% sucrose w/w) coagulated by Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus in proportions of 10, 20, 30 and 40% (v/ w). The control treatment consisted of yogurt added with sucrose (10% w / w). Analysis were performed to quantify dry mass, moisture, ash, protein, fat, sodium, acidity, total quantification of lactic acid bacteria, total antioxidant activity and viscosity at the initial time of production and at 15 and 30 days of storage. Chromatographic determination of volatile compounds and sensory tests of acceptance and consumption intention were conducted at the initial time of production. Dry matter content, moisture, ash and total count of lactic acid bacteria from fermented milk drink formulations were not significantly affected by the amount of infusion of C. sinensis. However, the content of protein, fat and sodium were significantly lower with the increase of the proportion of infusion incorporated into the product. Significant reduction in apparent viscosity occurs with the increase in the amount of infusion added. The total antioxidant activity of the formulations was significantly higher as higher were the amount of added infusion. The addition of infusion contributed to the diversification of volatile aroma and taste makers in the product. The formulation of fermented dairy drink with addition of 30% Infusion C. sinensis was better evaluated in sensory tests, with greater acceptance and greater consumer intent of consumption.
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AlGhamdi, Saleh Mohammed S. "An investigation of CTen signalling and regulation in cancer." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606811.
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C-terminal Tensin-like (Cten) is a member of the Tensin gene family but lacks the N-terminus actin-binding domain. Cten functions as a tumour suppressor in some cancers while in other cancer types it is recognized to have oncogenic activities. Our group has previously shown that, in colorectal cancer (CRC), Cten is up-regulated and acts as an oncogene which alters several cellular functions including cell migration and invasion. In this project we tried to understand (a) the mechanism through which Cten affects cell function and (b) the mechanisms by which Cten expression may be controlled in cancer. Three cancer models system (colorectal, pancreatic and lung cancer) have been tested to validate our observations. (a) Since Cten is found in complex with integrins at focal adhesions, we hypothesized that it may influence other molecules which are associated with focal adhesion and integrin function. Through a combined approach of forced expression and knockdown experiments, we examined the effect of Cten on ILK and FAK. We found that Cten positively regulates expression of both ILK and FAK and this may be the mechanism through which cell motility is controlled. (b) (i) Activation of the Epidermal Growth Factor Receptor (EGFR) signalling pathway in breast cancer results in up-regulation of Cten accompanied by down-regulation of Tensin 3 (known as the "Tensin switch"). We tested this in CRC and found that stimulation and inhibition of the EGFR using recombinant EGF and the EGFR inhibitor PD135053, resulted in changes in Cten expression (with a tensin switch) and changes in cell motility. Since EGFR classically signals through Kras/Braf we hypothesized that Kras (which is frequently mutated in CRC) may regulate Cten expression. Analysis of CRC cell lines showed an association between Kras/Braf mutation and high Cten expression. Knockdown of Kras in cell lines harbouring Kras mutations resulted in loss of Cten expression while no effect was observed in the cell lines with Braf ,mutations. However Braf knockdown in cell lines with Braf mutation resulted in down-regulation of Cten levels. (ii) CD24 has been shown to be associated with integrins suggesting a possible involvement with Cten at Focal Adhesions. Manipulation of CD24 protein levels in CRC cell lines was mirrored by changes in Cten expression although this effect was not accompanied by a tensin switch. (iii) STAT3 can function as both a tumour suppressor and an oncogene. Modulation of STAT3 levels - either directly through gene knockdown or indirectly through IL-6 stimulation - showed that STAT3 is a negative regulator of Cten. Since around 90% of pancreatic cancers and 60% of lung cancers have Kras mutations we repeated the experiments in these two models. Our data showed that functional activity and regulation of Cten was similar to that seen in CRCs. We can conclude that Cten can regulate cell motility through modulation of FAK and ILK. In addition, Cten is regulated by EGFRKras- Braf signalling and that CD24 and STAT3 are also, respectively, positive and negative regulators of Cten. Finally, Cten activity is broadly consistent in three different cancer models. Future studies should involve further refinement of the signalling pathway and study of other tumour types involving frequent Kras mutations. ..
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Akhlaq, Maham. "Investigation of Cten signalling and regulation in colorectal cancer." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32802/.
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Cten (also known as Tensin4) is the fourth member of the Tensin gene family. It lacks the N terminal actin binding domain while retaining the C terminal SH2 and PTB domains. This helps to bind Cten to the intracytoplasmic tail of β1 integrin and puts it at the heart of focal adhesions. It is reported to be a tumour suppressor in kidney and prostate cancer where normal tissues show high expression. However in a number of tumours, including colorectal cancer, Cten has been labelled as an oncogene. Cten which normally is a cytoplasmic protein gives nuclear staining in colorectal metastatic deposits. It increases motility, invasion and colony formation in colorectal cancer cells. In this study we have tried toexplore the mechanism of functional activity and regulation of Cten. We looked at Cten in the nucleus in vitro and identified new downstream binding targets. In addition we investigated the role of the SH2 domain of Cten concentrating on its downstream signalling molecules and binding partners. Furthermore, we explored regulators of Cten. In this study we have forced nuclear localisation of Cten by tagging it with a nuclear localisation sequence (NLS) and found a significant increase in cell motility. In order to investigate the SH2 domain we used site directed mutagenesis to change potentially important amino acids namely Arginine at 474 to Alanine (R474A), which is important for binding tyrosine phosphorylated proteins. Moreover, we displayed that Cten underwent tyrosine phosphorylation and additionally changed three tyrosine residues i.e. Y449F, Y479F and Y530F via site directed mutagenesis. We found R474 and Y479 to be important in regulating cell motility and that known downstream targets such as ILK and FAK are dependent on an intact SH2 domain. Furthermore we have identified Cten to be physically bound to FAK in the cytoplasm and nucleus and new downstream targets identified such as Src and Paxillin. Regarding possible regulators of Cten, we found that Cten might be a possible substrate for calpain. Another regulator considered was CD24 due to its role in movement of integrins into lipid rafts and we found it was a positive regulator of Cten. In conclusion localisation of Cten into the nucleus causes an augmentation of its motility enhancing functions. Cten regulates cell motility via its SH2 domain. Arginine 474 and Tyrosine 479 are important for its function. Cten regulates levels of ILK, FAK, Src and Paxillin through its SH2 domain and binds to FAK in both cytoplasm and nucleus. Calpain and CD24 were found to possible regulators of Cten in colorectal cancer. Future studies are needed to define its role in signalling at focal adhesions and these studies should be validated in other cancer cell models as well to establish Cten as regulator of cell motility in cancer.
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Allen, Kim M. "The Perceptions of Career and Technical Education (CTE) Teachers on the Influence of CTE on Student Engagement." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/29626.
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Learning in school requires active engagement. Student engagement is an important aspect for all students, whether urban, suburban, or rural, and regardless of socioeconomic background. Students enter Career and Technical Education (CTE) programs for a multitude of reasons and CTE programs offer unique support for student success by increasing student engagement. This study will focus on CTE teachers' perceptions of the influence that CTE programs and industry credentialing have on student engagement.
Utilizing information on student engagement will help educators develop strategies to promote student motivation and student engagement, thus leading to student academic success. This study is a quantitative, descriptive statistical study in which the researcher examined studies that focused on student engagement and student engagement predictors. The research identified six qualities of student engagement: positive conduct and absence of disruptive conduct, school attendance, academic progress, social membership, high expectations in students' ability to achieve, and emotional support. The researcher developed a survey to examine teachers' perceptions of CTE influence on student engagement by including the six qualities of student engagement as guidelines for questionnaire development.
Results of the survey indicate that CTE teachers identify all six domains of student engagement as represented within their course structure. Responses of all groups were similar, while their levels of industry involvement different. Additional results of all teacher responses are provided in the paper.Ed. D.
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Asiri, Abdulaziz. "Investigations into the role of Cten signalling in colorectal cancer." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52233/.
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C-terminal tensin-like (Cten, also known as Tensin4) is the member of the tensin gene family. Cten functions as an oncogene in a variety of cancer types and its expression is commonly associated with poor prognosis and metastasis in colorectal cancer (CRC). Although several studies have shown that Cten has a critical role in the regulation of cell motility and invasion in different tumour tissues, the underlying signalling mechanisms have not been fully elucidated. This thesis investigated the biological activity of Cten in four different ways in order to further elucidate the mechanisms of Cten signalling in CRC cells. Potential downstream targets of Cten signalling involved in the regulation of epithelial-to-mesenchymal transition (EMT) induced cell motility i.e. Rho-associated protein kinase1 (ROCK1), Src and Snail were investigated. Cten expression was manipulated in different cell lines using multiple approaches including forced expression, gene knockdown and constitutive depletion (through Crispr/Cas9 gene deletion) to eliminate artefacts of methodology and cell line specific effects. Snail, Src and ROCK1 were identified as novel downstream targets of Cten signalling and additionally, Cten was shown to increase the stabilisation of both Src and Snail proteins. The functional relevance of Cten-Snail, Cten-Src and Cten-ROCK1 signalling was assessed, and the overall findings demonstrated that Cten could promote cell motility and colony formation directly through the positive regulation of the Src/ROCK1/Snail dependent axis. To gain a deeper insight into the mechanisms of Cten’s biological function, mutations, at two important residues (i.e. arginine 474 and tyrosine 479) in the Src homology 2 (SH2) domain of Cten were introduced into one construct (GFP-CtenR474A+Y479F) using site directed mutagenesis. These two residues in the SH2 domain of Cten were found to not only be important for interacting with Src, ROCK1, or Snail signalling, but also for regulating cell motility and colony formation efficiency. Numerous Cten regulatory factors have been identified, however, little is known about how Cten is activated and regulated in cancer cells. The relationship between transforming growth factor beta 1 (TGFβ1) and Cten was investigated and stimulation of cells with TGFβ1 or knockdown of TGFβ1 resulted in changes in Cten expression as well as its downstream targets of ROCK1, Src, Snail, and N-cadherin. Furthermore, this positive interaction between TGFβ1 and Cten was functionally relevant and caused changes in cell motility. and the nuclear translocation of ROCK1, Src, and Snail protein increased by TGFβ1 is probably mediated via upregulation of the Cten signalling pathway The biological function of Cten in the nucleus was further investigated and shown to increase nuclear localisation of Src, ROCK1, and Snail, further promoting the migratory capability and colony formation efficiency in CRC cells. Finally, Cten expression was shown to positively correlate with both ROCK1 and Src expression in a series of primary CRCs. This correlation was consistent with that observed following manipulation of Cten expression in CRC cell lines. In conclusion, this study has revealed a number of novel findings regarding the biological function of Cten signalling in CRC. However, further validation of the findings may enhance the understanding of the role of Cten in the invasion-metastasis cascade in the future.
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GERMANO, SERGIO BRAGANTINE. "METROLOGICAL RELIABILITY OF THE DYNAMOMETRIC BENCH FOR ENGINE TESTING OF CTEX." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23215@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROINSTITUTO MILITAR DE ENGENHARIA
CENTRO TECNOLÓGICO DO EXÉRCITO
Nesta dissertação buscou-se avaliar metrologicamente um banco de ensaios dinamométricos específico, utilizado para analisar a eficiência de motores, lubrificantes e combustíveis, por meio de métodos de comparação dos valores medidos com valores padrões. As grandezas mensuradas foram: velocidade de rotação do eixo de um motor, torque neste eixo, temperaturas e pressões no motor e no dinamômetro, elemento que atua como freio do motor para proporcionar uma simulação das condições reais de trabalho. Foi necessário utilizar dois métodos distintos para avaliação de cada uma das grandezas mensuradas. Foram mensuradas velocidades do motor funcionando e velocidades simuladas, tanto inferiores como superiores às velocidades de operação do motor, determinando os limites superior e inferior de resposta do sistema de medição. Para avaliar a medição de torque, foram produzidos torques conhecidos (padrão), correlacionados com torques medidos no motor funcionando. Temperaturas foram produzidas por um banho termostático, mensuradas com equipamentos calibrados e em seguida comparadas com as indicadas pelo sistema de medição, sendo também utilizado um método simulador de informações de temperaturas, chegando a ser simuladas de -200 graus Celsius a 650 graus Celsius. Pressões foram geradas por uma bomba de pressão padrão e lidas pelo sistema de medição, sendo detectado funcionamento inapropriado de 2 canais. Os resultados de cada grandeza foram tratados estatisticamente sendo validadas suas utilizações nos cálculos executados. Confirmadas estatisticamente as validades dos resultados, as incertezas de medição foram calculadas, sendo utilizadas também informações dos certificados de calibração dos equipamentos usados nas medições realizadas. Sugestões foram apresentadas para que melhoria sejam incrementadas ao sistema de medição que demonstrou estar funcionando de forma satisfatória, apresentando, no entanto, algumas oportunidades de melhorias.
This work intended to evaluate, metrologically, a specific bench of dynamometric tests, used to analyze the efficiency of engines, lubricants and fuels, through methods that compare the measured values with standards. The measured quantities were: rotation speed of the engine shaft, torque on this same shaft, temperature and pressure of both engine and dynamometer, element that acts as the engine brake so it can simulate a real work condition. It was necessary to use two different methods to evaluate each measured quantity. It was measured the working engine speed and simulated speeds, both higher and lower than the engine operating speeds, establishing the higher and the lower limits of the measurement system. To evaluate the torque measurement, known torques (standards), were produced, and related to the measured torques in the working engine. Temperatures were produced by a thermal bath, measured with calibrated equipment, and then compared with the temperatures indicated by the measuring system, being also used a simulated method for temperatures information, with a range of simulation between -200 Celsius degrees and 650 Celsius degrees. The pressures were created by a standard pressure pump and read by the measuring system, being detected an inappropriate operation of 2 channels. The results were treated statistically, being validated the utilizations on the executed calculations. Having been statistically confirmed the validity of the results, the measurement uncertainties were calculated, being also used the information from the equipment calibration certificate. Suggestions were presented so that improvemenst can be made to the Measuring System.
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DeLuca, Todd A. "A Technical Writing Internship with CTC Parker Automation." Miami University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=miami1006205131.
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Scobba, Tracy L. "An Internship Preparing User Documentation at CTC Parker Automation." Miami University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1083282037.
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Terrieux, Agnès. "Les territoires de référence dans les CTE (contrats territoriaux d’exploitation)." Toulouse 2, 2007. http://www.theses.fr/2007TOU20043.
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A l'occasion de l'écriture de la loi d'orientation agricole de 1999, la référence explicite au territoire entre dans le vocabulaire de la politique publique agricole. La procédure mise en place pour la détermination des contenus des Contrats Territoriaux d'Exploitation, CTE, est expérimentale et largement ascendante. Cette thèse propose une analyse des conceptions et pratiques du territoire qui ont été construites et mobilisées par des acteurs individuels et collectifs à l'occasion de cette procédure. Quel rôle et quelle place joue le territoire aujourd'hui dans les projets de vie et les projets professionnels des agriculteurs et des agents de développement du Tarn et de l'Aude ? Quelle place ont ces groupes sociaux dans les projets territoriaux ? En montrant comment la ré-interprétation du territoire a permis des échanges et la construction de compromis localisés, nous proposons un éclairage sur une procédure qui avait pour objectif de revivifier les liens entre les agriculteurs et la société en usant de(s) territoire(s)When the French government decided to have a new Agricultural Act voted in 1999, it used the word « territory » as an incentive for farmers and extension workers to find a new way to interact with the whole society. Taking into account that the status of agriculture in the contemporary rural communities was at stake, farmers and extension workers in Aude and Tarn have tried to work on a renewal of the ways and means of the word “territory”. In this work I point out how people dealt with the different means of the word “territory” to build a common ground on which to build new ways to share the rural space, live, work, network in an extended and open community aiming at local and global sustainability
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White, David Owen. "The Impact of Career and Technical Education (CTE) on Student Academic Achievement and Graduation Rates in the Commonwealth of Virginia." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/74382.
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The No Child Left Behind (NCLB) Act of 2001 required that states set clear standards for what all students should learn, and hold schools accountable for student progress in the areas of language arts, reading, and mathematics to assess their abilities (USDOE, 2002). However, while NCLB emphasizes the core academic subjects (i.e., English, reading/language arts, mathematics science, foreign languages, civics and government, economics, arts, history, and geography), it neglected to address Career and Technical Education (CTE) (i.e., agriculture; business and information technology; family and consumer sciences; marketing; health and medical sciences; technology; or trade and industry) in any part of the legislation. The purpose of this study was to compare the academic performance of CTE completers and non-CTE completers in the Commonwealth of Virginia on the Standards of Learning (SOL) Reading and mathematics assessments, and graduation rates. This study was modeled after and was an extension of a previous study by Blowe (2011), and represented a quantitative, quasi-experimental, correlational evaluation of ex post facto data to determine the effects of being a CTE completer on student academic success in high school. The findings show that the mean pass rate for CTE completers was higher than the mean pass rate for non-CTE completers for both the EOC Reading and EOC Algebra II SOLs, and that the mean graduation rate for CTE completers was higher than the mean graduation rate for non-CTE completers for each of the graduation cohorts years included in the study. An additional finding was the discovery of reporting discrepancies in division-reported data published by the VDOE. The findings in this study provided the researcher with valuable insight into the potential role of CTE in an improving schools model, including the utilization of a rigorous CTE curriculum as a strategy for improving SOL scores and graduation rates for all students. Additionally, this information may prove beneficial to educational and legislative leaders in developing policies governing CTE curriculum throughout the Commonwealth of Virginia.Ed. D.
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Sjoestroem, Anna Cecilia. "An investigation into the role of C-terminal tensin-like protein (Cten) in melanomagenesis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45282.
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C-terminal tensin-like protein (Cten) is a focal adhesion protein with no or limited protein expression in normal tissues, which has recently been reported to be overexpressed and act as an oncoprotein in numerous cancers. Since its expression status in human cutaneous melanoma is currently unknown, I used tissue microarrays and immunohistochemical staining to examine the protein expression of Cten throughout melanoma progression. I found that Cten was significantly up-regulated in dysplastic nevi (DN) compared to normal nevi (NN), and in primary melanoma (PM) compared to both DN and NN. Strong Cten staining was associated with a poorer 5- and 10-year overall and disease-specific survival for PM patients, and was an adverse independent prognostic factor for the 5-year survival of the same patients. In vitro studies using two melanoma cell lines supported these findings and indicated that Cten functions as an oncogene in melanoma.
Since relatively little is known about how Cten contributes to tumorigenesis, I next investigated the expression profile of the RhoGAP Deleted in Liver Cancer-1 (DLC1), the only protein known to bind to Cten, in melanomas. Both cytoplasmic and nuclear DLC1 were detected, and both were down-regulated in metastatic melanoma (MM) compared to PM and nevi, with nuclear DLC1 expression additionally being reduced in PM compared to nevi. Both cytoplasmic and nuclear DLC1 were associated with the 5-year overall and disease-specific survival of all melanoma and MM patients, and with the disease-specific 10-year survival of all melanoma patients. Combined analysis of cytoplasmic and nuclear DLC1 revealed that for MM patients, concurrent loss of both cytoplasmic and nuclear DLC1 was associated with the worst survival outcome, with loss of either or both forms being a significant adverse independent prognostic factor for the 5-year survival of all melanoma and MM patients. A preliminary investigation into the relationship between Cten and DLC1 indicated that the effects of Cten on patient survival were dependent on the levels of DLC1, as expected.
In summary, I here provide an initial characterization of the expression status and role of Cten in melanomagenesis, and speculate that it functions partly via interactions with the tumour suppressor DLC1.
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Sousa, Cleide Maria da Silva e. "Centro de Memória da CTBC e sua integração ao processo de comunicação da empresa." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87233.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.Made available in DSpace on 2012-10-21T16:51:07Z (GMT). No. of bitstreams: 1 224865.pdf: 1793257 bytes, checksum: 82bb8d9ca82ea382d26ce5164ea479fb (MD5)
A revisão teórica sobre comunicação, comunicação empresarial, comunicação interna e externa, cultura organizacional e memória empresarial resultou, neste trabalho, no modelo de análise Comunicação, Imagem, Identidade e História. Tal modelo foi a base para a observação da realidade empresarial, da estrutura e funcionamento do acervo histórico em implantação pela CTBC, empresa do Grupo Algar prestadora de serviços na área de telecomunicações e que completará cinqüenta anos de atuação em fevereiro de 2004. O acervo analisado, denominado Centro de Memória CTBC, e em fase de criação desde 1999, dentro de um programa de memória empresarial, já tem catalogados documentos, fotos, publicações, vídeos, equipamentos, objetos e, principalmente, depoimentos gravados com funcionários e ex-funcionários com o objetivo de resgatar a história da Empresa. Para avaliar a importância do programa de memória empresarial, ou seja, se ele contribui com o processo de comunicação na consolidação da imagem e da cultura organizacionais, este estudo de caso teve como premissa analisar, por meio do acervo disponível, se a identidade da Empresa está em sintonia com a imagem desejada. A referência para tal análise foi encontrada em itens de Crenças e Valores e Competências Essenciais seguidas pela CTBC e pelo Grupo Algar. A conclusão, após observação e vivência diária da pesquisadora, como funcionária da CTBC, e consulta ao acervo, de acordo com a metodologia estabelecida, foi que o acesso à história da Empresa permitiu verificar que há um alinhamento cultural, em cinco décadas de mudanças sociais, econômicas, políticas e administrativas, que corresponde à necessidade da organização de preservar seus valores básicos, o que mostrou a importância do Centro de Memória ao contribuir, como ferramenta do processo de comunicação, para consolidar a imagem e a cultura organizacionais. external communication, organizational culture and company memory resulted, in this study, in an analysis model of Communication, Image, Identity and History. That model was the basis for the observation of the company reality, of the structure and function of the historical background being implanted by CTBC, an Algar Group company rendering services in the area of telecommunications and which will complete fifty years of activity in February, 2004. The background analyzed, denominated Memory Center CTBC, in its creational phase since 1999, within a company memory program, has already catalogued documents, pictures, publications, videos, equipment, objects and, principally taped testimonies with workers and ex-workers with the objective of recovering Company history. To evaluate the importance of the program of company memory, or in other words, if it contributes to the communication process of consolidating the image and organizational culture, this case study had as its premise, the analysis, from the available records, as to whether the Company identity is in harmony with the desired image. Reference for such analysis was found in items of Beliefs, Values and Essential Skills followed by CTBC and the Algar Group. The conclusion reached, after personal, daily contact by the researcher, as a CTBC worker and background consultation, according to the established methodology, was that access to the Company history permitted the verification of cultural alignment, in five decades of social, economic, political and administrative changes, that correspond to organizational necessity for the preservation of its basic values, which showed the importance of the memory center contributing, as a tool in the process of communication, to consolidate organizational image and culture.
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Kousa, Anastasia. "Interrogation of transcriptional, regulatory and signalling networks in fetal thymic epithelial cell development via in silico analyses." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33065.
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The thymus is the primary lymphoid organ responsible for the development and maturation of T lymphocytes (aka T-cells) in vertebrates. The complex architecture of the thymic microenvironment orchestrates the formation of a diverse and self-tolerant T-cell repertoire capable of supporting the development and maintenance of a functional immune system. The main component of this microenvironment, the thymic epithelium, is crucially required to direct thymus organogenesis and homeostasis, and to mediate T-cell repertoire development and selection. The thymic epithelial progenitor cells (TEPCs) from which the mature thymus develops originate from the endoderm of the 3rd pharyngeal pouch by embryonic day 9 in mouse development (or early week 6 in human embryos). Expression of the transcription factor FOXN1 is required to drive TEPCs differentiation in each thymic epithelial lineage (TEC), while the absence of functional FOXN1 causes athymia. Moreover, forced expression of Foxn1 in mouse embryonic fibroblasts (MEFs) converts these MEFs into TECs that can support the development of a normal thymic system. Despite the great therapeutic potential that TEPCs present in regenerative medicine, there is currently no detailed model describing regulation of the TEPC state and its differentiation into cortical (c) and medullary (m) TECs, or explaining the dominant role of FOXN1 in the thymic epithelial system. Comparative transcriptomics analysis in conjunction with pathway enrichment analysis of the developing TEPCs could reveal the signalling pathways that regulate the early TEPC state and progression into differentiation. Additionally, integrative bioinformatics analysis of transcriptomics and genomics datasets could identify the functional networks that are directly regulated by FOXN1 during early TEC progression. In this thesis I provide, for the first time, an in silico model explaining fetal TEPC differentiation into the functionally distinct TEC lineages, in the cellular, molecular and signalling contexts of thymus early development. Furthermore, I present evidence which suggests that FOXN1 could be a pioneer factor, capable of fully establishing the transcriptional programme that underpins thymic epithelial cell identity and function. Finally, in this thesis, I introduce the development of an interactive thymic-specific database that provides a platform for easy access, analysis and integration of curated bioinformatics datasets.
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Hasler, John. "Stichwort: Der Ausschuß zur Bekämpfung des Terrorismus - Counter Terrorism Committee (CTC)." Universität Potsdam, 2004. http://opus.kobv.de/ubp/volltexte/2011/5564/.
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Albasri, Abdulkader. "An investigation of the role of C-terminal tensin-like (Cten) gene in colorectal cancer." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12055/.
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The C-terminal tensin-like (Cten) gene is a member of the tensin family and is localised at the cytoplasmic tail of β-integrin. It is involved in various biological events although the role of in the development of colorectal cancer (CRC) is uncertain. In order to study this, the expression of Cten during the development of CRC was initially evaluated using immunohistochemistry (IHC) on colorectal adenomas and carcinomas. Positive immunoreactivity for Cten was observed in 317/342 (92.6%) of CRC and 19/20 (90%) of colorectal adenoma. High Cten expression was significantly associated with advance Dukes stage (p=0.001), lymph node metastasis (p<0.001), extra-mural vascular invasion (p=0.001) and distant metastases (p=0.008). Survival analysis demonstrated that patients with high Cten expression had significantly shorter disease free survival (DFS) on univariate analysis (p<0.001) a trend towards Cten expression as an independent predictor of DFS on multivariate analysis (p=0.071). To further test the association with metastasis, the role of Cten in metastasis was tested by (a) intrasplenic injection of CRC cells stably transfected with Green Fluorescent Protein (GFP) tagged Cten into nude mice and (b) testing a series of primary CRCs and their metastases by IHC. Compared with control mice (injected with cells transfected with GFP empty vector), mice injected with cells expressing Cten developed larger tumours in the spleen (p=0.03) and liver (p=0.05). Compared with primary tumours, the metastatic deposits had a significantly higher frequency of nuclear localisation of Cten (p=0.002). To further investigate the potential role of Cten in metastasis, in-vitro models were used to investigate Cten function. Ectopic expression of Cten in the HCT116 CRC cell line (which expresses low levels of Cten) caused changes in cell morphology and increased cell motility (both migration and invasion). Conversely, the reciprocal Cten knock-down experiments in SW620 CRC cell line (which expresses high levels of Cten) resulted in inhibition of both cell migration and invasion. Since Cten is in complex with integrins at focal adhesions, its interactiosn with integrin-linked kinase (ILK), focal adhesion kinase (FAK) and CD24 were tested. Cten was shown to regulate ILK, FAK and CD24. Moreover, inhibition of CD24 after forced expression of Cten abrogated the Cten-mediated effects on both cell motility and protein levels of ILK and FAK. The studies were expanded and Cten expression was tested by IHC in another cancer model i.e. breast cancer (BC).Consistent with the data from CRC, increased Cten expression in BC was found to be associated with poor prognostic variables and shorter disease free survival. In conclusion, Cten expression is associated with poor prognosis in CRC and BC. This may be consequent to an ability to enhance metastasis which is related to promotion of cell motility. The activities of Cten are probably consistent across different tumour models.
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Nguyen, Amy L. "Incorporating CTEA as a screening tool to enhance the process of obtaining training effectiveness estimates." Master's thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-03172010-020218/.
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Lindquist, Per J. G. "Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-878-5/.
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Sayers, Jerry Alan. "Career and Technical Education (CTE) and High School Student Success in Tennessee." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2479.
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The purpose of this quantitative study was to examine the relationship between participation in CTE programs and students’ graduation rates and rates of CTE students’ entrance into postsecondary education or employment after graduation. Possible differences between students’ enrollment in urban and rural school districts and their graduation, participation, and secondary placement rates were also considered. Publicly available data on high school students in the state of Tennessee were analyzed to compare the graduation rates of CTE participants with the graduation rates of non-CTE participants in the state as a whole and in nine selected urban school districts and nine selected rural school districts for the school years 2009-2010, 2010- 2011, and 2011-2012.
Research cited in this study indicated that CTE participation could increase students' graduation rates. Some research also indicated that rural students were more likely to complete CTE concentrations than urban students and that other differences might exist in the CTE experiences of urban and rural students. Six research questions were created and their null hypotheses tested with a series of z-tests.
Analysis of publicly available data for the selected school systems and for the state as a whole found slightly higher rates of graduation among CTE concentrators than among non-concentrators and higher rates of CTE participation among rural than urban high school students, but these differences were not statistically significant. Differences between urban and rural schools systems' graduation rates and their rates of postsecondary placement of CTE concentrators in education, the military, or employment were also found to be statistically insignificant.
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Loveless, Melissa Ann. "Career and Technical Education (CTE) Graduation Rates in Tennessee: A Comparative Study." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1330.
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The purpose of this quantitative study was to determine if the number of Career and Technical Education (CTE) graduates who go on to postsecondary education or some other training program, to the military, or to employment upon high school graduation was significant in comparison to the state baseline for secondary placement. This study further compared CTE graduation rates to overall graduation rates. The graduation rates were compared based on gender as well. School systems that provided CTE courses and that had CTE concentrators for the 2007-2008 and 2008-2009 school years were used for this study. Eight school districts were chosen in the upper east Tennessee region and were evaluated using graduation data and secondary placement data from the Tennessee Department of Education Report Card.
The research cited in this study supported the supposition that CTE graduates do in fact help to increase the overall graduation rates for school districts. This study focused on five research questions and each null hypothesis was tested using a one-sample chi-square test.
Results indicated that there were positive significant differences for CTE concentrators who proceed to postsecondary education, military, and employment as compared to the state baseline for secondary placement. The study further revealed that the graduation rate for Tennessee CTE concentrators was higher than the overall graduation rate for the selected school districts in this study. Positive differences were also noted between the sample CTE graduation rate and the overall Tennessee CTE graduation rate as well as between those rates and the overall Tennessee graduation rate for all students. Further analysis revealed that no significant differences existed between male CTE graduates and female CTE graduates. The research findings suggested that CTE graduation rates can help improve a school district's overall graduation rate.
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Shadden, Richard Ernest Jr. "The Graduation Rates of Career and Technical Education (CTE) Concentrators in Tennessee." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1243.
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The purpose of this quantitative study was to compare high school graduation rates between Career and Technical Education (CTE) concentrators and non-CTE concentrators. School systems in the state of Tennessee that offered CTE courses for the 2007-2008 (120 systems) or 2008-2009 (118 systems) school years were used in this study. Fifteen northeast Tennessee systems were also examined to compare the graduation rates of CTE concentrators and non-CTE concentrators. The graduation rates of male and female CTE concentrators was also compared.
Research supported the notion that CTE concentrators could improve overall graduation rates for school systems, and female CTE concentrators on average graduate at a higher rate than male CTE concentrators. Five research questions guided this study, and data were analyzed using independent-samples t tests and one-samples t tests.
Results indicated that 12th-grade CTE concentrators had a higher graduation rate than non-CTE concentrators. The study further revealed that female CTE concentrators graduated at a significantly higher rate than male CTE concentrators. Findings suggested that CTE concentrators generally improved a school system's overall graduation rate.
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Hadri, Ferhat. "Contribution à l'étude de la réduction de la traînée en écoulement turbulent d'une solution de CTAC." Phd thesis, Université de Caen, 2008. http://tel.archives-ouvertes.fr/tel-00464084.
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La réduction de la traînée est un phénomène d'écoulement qui, par la présence de très petites quantités d'additifs (polymères ou tensio-actifs) dans un fluide quelconque, consiste en une réduction significative du frottement à la paroi en régime turbulent. Certaines solutions d'additifs, en interagissant avec la structure de la turbulence conduisent à une réduction du frottement pouvant aller jusqu'à 90 % par rapport au solvant pur. Ceci induit une réduction de la puissance de pompage de l'ordre de 30 %. La réduction de la traînée peut trouver son application dans des systèmes de chauffage et de refroidissement urbains, dans le domaine pétrolier (pipelines), ... Dans ce travail de thèse une contribution à l'étude de ce type d'écoulement a été menée. Une solution réductrice de la traînée à base de « CTAC/NaSal » à faible concentration a été largement explorée. La rhéométrie, la vélocimétrie par images de particules (PIV) et des modèles numériques sont utilisés. Ainsi, les solutions de tensio-actifs ont été caractérisées rhéologiquement. Plusieurs paramètres influençant la réduction de la traînée en conduite ont été étudiés. Le phénomène de glissement à la paroi a été abordé par une étude dans une géométrie de Couette. Enfin, un modèle de comportement rhéologique issu des mesures rhéologiques a été testé par Simulation Numérique Directe (DNS). Les principaux résultats qui ressortent de ce travail montrent que le mécanisme de la réduction de la traînée est conditionné par plusieurs paramètres par contre, le glissement à la paroi n'est pas forcement responsable de la réduction de la traînée.
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Salamoni, Rafael Hollweg. "VIABILIDADE DO PROCESSO OPERACIONAL DA CENTRAL DE TRATAMENTO DE RESÍDUOS DA CATURRITA (CTRC) SANTA MARIA, RS." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/7716.
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This approach identifies some physical characteristics of the residues and the operational procedures converning the destination of these residues at the Central of Residues Treatment of Caturrita (CTRC), located on the city of Santa Maria (RS). The CTRC is composed by unit of selection, unit of compostage and sanitary embarement, wich supports a population of nearly 500.000 habitants, and has a 30 years estimated life-time for the enterprise. It is located in area of 24, 7 hectares, within the Vicinal Road to Santa Maria (Boca do Monte). The enterprise is licensed to daily receive 300t of residues. The physical characteristics and the operational
procedures were taken and executed with the residue from the selection unit. It evaluated the specific mass and the operational procedures of compacting, receiving of residues, transport of residues to the landfill place, utilized machines and life-time of the sanitary embarement for the actual operational system and for the operational
system that uses a press to compact the residues. Sixteen packs of compact residues using a vertical press. The evaluation results showed a significant operational and economic qualification in the operational system of compacting residues in press. This is due to the fact that the residues were compacted in smell volumes, forming easy operated packs with higher values of specific mass. The
compactation of the residue in a vertical press provided an increase in the specific mass and consequently a volumetric reduction of 5, 33 times. These residues were
compacted in sunny and rainy days and with presence of organic matter, and for that, the compactitation generated effluent in significant amount, wich any was would be
generated in the sanitary embarement. There was no way to set, through the availall data, the days and intervals of peak hours, but it was verified that the amount of
processed residues by hour is lawer than to the amount produced with the operational processing of presses of the type MAC 108L/1. The compaction process showed a gain in efficiency in charge of 28.6% and the economy in the consume of diesel of 31,5%. The managing of machinery to compact residues in press demonstrated a reduction in the number of utilized equipments and the life-time of
the sanitary sanitary embarement for compacted residues by press would pass from 30 years for 39, 1 years.Neste trabalho foram identificadas algumas características físicas dos rejeitos e os procedimentos operacionais da destinação destes rejeitos na Central de Tratamento de Resíduos da Caturrita, (CTRC) localizada no município de Santa Maria (RS). A CTRC é composta por unidade de triagem, unidade de compostagem e aterro sanitário e atendendo uma população de 500.000 habitantes, tendo uma vida útil estimada de 30 anos. Possui uma área de 24,7ha, localizada junto à Estrada geral da Boca do Monte. O empreendimento está licenciado para receber 300t de resíduos diariamente. O estudo das características físicas e os procedimentos operacionais foram realizados com o rejeito da unidade de triagem. Avaliou-se a massa específica e os procedimentos operacionais de compactação, recebimento de resíduos, transporte de rejeitos para o aterro sanitário, maquinários utilizados e vida útil do aterro sanitário para o sistema operacional atual e para sistema operacional que utiliza prensa para compactar os rejeitos. Foram confeccionados 16 fardos de rejeitos compactados em prensa vertical. Os resultados mostraram uma significativa qualificação operacional e econômica no sistema operacional de compactação de rejeitos em prensa. Isto é devido ao fato dos rejeitos serem compactados em pequenos volumes e formarem fardos de fácil operação com maiores valores de massa específica. A compactação de rejeito em prensa vertical proporcionou um aumento da massa específica e conseqüentemente uma redução volumétrica de 5,33 vezes. Estes rejeitos foram compactados em dias secos e chuvosos e com presença de matéria orgânica, e por isso, a compactação gerou efluente em quantidade significativa, mas que por sua vez seria gerada no aterro sanitário. Não houve como dimensionar através dos dados encontrados os dias e intervalos de horas de pico, mas verificou-se que as quantidade de resíduos processados por hora são inferiores à capacidade de processamento operacional de prensas do tipo MAC 108L/1. O processo de compactação apresentou um ganho de eficiência na carga de 28,6% e uma economia de 31,5% no consumo de diesel. O dimensionamento de maquinários para compactar os rejeitos em prensa demonstra uma redução no número de equipamentos utilizados e a vida útil do aterro sanitário para rejeitos compactado em prensa passaria de 30 anos para 39,1anos.
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Gavin, John. "The application of image analysis to the assessment of contact lens disinfectants against bacterial biofilms." Thesis, Glasgow Caledonian University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285237.
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Davis, Bernard Sydnor III. "A Comparative Study of Leadership Characteristics of Virginia Regional Technical Center Principals." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73813.
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The purpose of this study was to identify leadership characteristics of technical school principals as perceived by technical center school principals, the superintendents, and the center's Joint Control Board of the regional technical centers of the Commonwealth of Virginia. A regional technical center principal position deals with a different administrative governing board, students from different high schools, and courses in the field of career and technical education. This study gathered and evaluated perspectives from the participating superintendents, Joint Control School Board members, and regional technical center principals to determine similarities and differences between the perceptions among these groups.
The population selected for this study was comprised of the participating superintendents, school board members, and principals from all ten K-12 public school regional technical centers in the Commonwealth of Virginia during the 2014-15 school year. The results showed that the survey respondents ranked visionary and instructional leader as the top two characteristics for regional technical center principals. The results showed that superintendents and Joint Control School Board members ranked having a background or experience in career and technical education higher than principals ranked that characteristic. Joint Control Board Members ranked having a CTE degree significantly higher than principals and superintendents. Superintendents and Joint Control Board Members rated the principal's ability to articulate an instructional vision as having a significant relation to academic success higher than principals rated that characteristic. Survey respondents rated statement ten; persuasion is the ultimate tool for a technical center principal of public education, mean responses the lowest. All three survey respondents rated statement six; personal and professional integrity, honesty, and fairness are essential leadership characteristics for the public school regional technical center principal, mean responses the highest.
Open-ended question sixteen, what other characteristics that are needed for the CTE leader of a regional technical center that have not been addressed?, revealed results that superintendents and principals indicated that personnel management was a valuable skill, that superintendents believed that building relationships with students and recruiting students along with having the ability to work with various stakeholders was important.Ed. D.
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Dweck, David. "Challenging Current Paradigms Related to Cardiomyopathies: Are Changes in the Calcium Sensitivity of Myofilaments Containing Mutations Good Predictors of the Phenotypic Outcomes?" Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/313.
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Three novel mutations (G159D, L29Q and E59D/D75Y) in cardiac troponin C (CTnC) associate their clinical outcomes with a given cardiomyopathy. Current paradigms propose that sarcomeric mutations associated with dilated cardiomyopathy (DCM) decrease the myofilament calcium sensitivity while those associated with hypertrophic (HCM) cardiomyopathy increase it. Therefore, we incorporated the mutant CTnCs into skinned cardiac muscle in order to determine if their effects on the calcium regulation of tension and ATPase activity coincide with the current paradigms and phenotypic outcomes. This required the development of new calculator programs to solve complex ionic equilibria to more accurately buffer and expand the free calcium range of our test solutions. In accordance with the DCM paradigms, our result show that G159D and E59D/D75Y CTnC decrease the myofilament calcium sensitivity and force generating capabilities which would likely increase the rate of muscle relaxation and weaken the contractile force of the myocardium. Alternatively, the lack of myofilament change from L29Q CTnC (associated with HCM) may explain why the only proband is seemingly unaffected. Notably, the changes in the calcium sensitivity of tension (in fibers) do not necessarily occur in the isolated CTnC and vice versa. These counter-intuitive findings are justified through a transition in calcium affinity occurring at the level of cardiac troponin (CTn) and higher, implying that the true effects of these mutations become apparent as the hierarchal level of the myofilament increases. Despite these limitations, the regulated thin filament (RTF) retains its role as the calcium regulatory unit and best indicates a mutation's ability to sensitize (+) or desensitize (-) the muscle to calcium. Since multiple forms of cardiomyopathies exist, the identification of new drugs that sensitize (+) or desensitize (-) the calcium sensitivity could potentially reverse (+ or -) these aberrant changes in myofilament sensitivity. Therefore, we have developed an RTF mediated High Throughput Screening assay to identify compounds in libraries of molecules that can specifically modulate the calcium sensitivity of cardiac contraction. The knowledge gained from these studies will help us and others to uncover new pharmacological agents for the investigation and treatments of cardiomyopathies, hypertension and other forms of cardiovascular diseases.
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Yeary, Amber J. "Cetyltrimethylammonium Halide-Coated Electrodes for the Detection of Dopamine in the Presence of Interferents." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1323471405.
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Cruzat, Grand Josefina 1983. "The Effective communication of brain network dynamics under different states." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670059.
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Cognitive processing requires to flexibly combine information from functionally specialized neural processes that are widely distributed throughout the brain. Neuroimaging studies have consistently reported that functional network configurations are governed by two fundamental principles of brain organization: functional segregation and integration. Yet, the mechanisms underlying the dynamic network reorganization are not well understood. In this work, we present evidence for two mechanisms through which the dynamic system-level integration is modulated. On the one hand, the large-scale brain organization is mediated by transient changes in phase-synchronization, facilitating global information flow between distant cortical areas as proposed by the "Communication Through Coherence" (CTC) theory. And in the other, it is mediated by the ascending neuromodulatory system. Neuromodulators constrain local processes by selectively changing the balance of the excitation and inhibition of individual brain regions.El procesamiento cognitivo requiere combinar de manera flexible la información de procesos neuronales funcionalmente especializados que están ampliamente distribuidos por todo el cerebro. Los estudios de neuroimagen han informado consistentemente que las configuraciones de red funcional se rigen por dos principios fundamentales de la organización del cerebro: segregación funcional e integración. Sin embargo, los mecanismos subyacentes a la reorganización dinámica de la red aún no son bien comprendidos. En este trabajo, presentamos evidencia en soporte de dos mecanismos a través de los cuales se modula la integración dinámica a nivel de sistema. Por un lado, la organización del cerebro a gran escala está mediada por cambios transitorios en la sincronización de fases, lo que facilita el flujo de información global entre áreas corticales distantes como lo propone la teoría de "comunicación a través de la coherencia" (CTC). Y por otro, está mediada por el sistema neuromodulador ascendente. Los neuromoduladores restringen los procesos locales al cambiar selectivamente el equilibrio de la excitación e inhibición de las regiones cerebrales individuales.
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Pimienta, Genaro. "Structural characterization of a protein-RNA complex human TAP-NXF1 protein-retroviral CTE RNA /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973946571.
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Peter, Geoffrey J. M. "Numerical simulation of CTE mismatch and thermal-structural stresses in the design of interconnects /." Full text open access at:, 2001. http://content.ohsu.edu/u?/etd,235.
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Sloan, Sandra Dale. "Enrollment, Attainment, and Occupational Outcome Patterns of Subbaccalaureate CTE Business Students: A National Analysis." OpenSIUC, 2008. https://opensiuc.lib.siu.edu/dissertations/279.
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AN ABSTRACT OF THE DISSERTATION OF Sandra D. Sloan, for the Doctor of Philosophy degree in Workforce Education and Development, presented on October 23, 2008 at Southern Illinois University Carbondale. TITLE: ENROLLMENT, ATTAINMENT, AND OCCUPATIONAL OUTCOME PATTERNS OF SUBBACCALAUREATE BUSINESS STUDENTS: A NATIONAL ANALYSIS MAJOR PROFESSOR: Dr. MARCIA A. ANDERSON Participation in postsecondary education has increased in the last few decades, and subbaccalaureate career and technical education (CTE) is an important part of that educational system. By federal mandate, the National Center for Education Statistics (NCES) has collected data and compiled statistical reports regarding participation in subbaccalaureate CTE through the Career and Technical Education Statistics System. Within subbaccalaureate CTE, one of the most popular programs is business. Although data is collected on subbaccalaureate CTE business students, and even though there are some reports that have specifically included findings regarding these students, very little extensive research has been done on their enrollment, attainment, and occupational outcomes leaving a gap in the research for shareholders in business education. This study attempted to fill that gap. Conclusions from this study indicated that the most significant change in subbaccalaureate CTE business programs over a 15-year period was the decrease in overall enrollment. However, aside from a few exceptions, the composition of subbaccalaureate CTE business students remained stable. The majority population enrolling into subbaccalaureate CTE business programs over a 15-year period were unmarried, White females under the age of 24. The few significant changes included a decrease in the proportion of the White population, an increase in the proportion of the Black population, an increase in the proportion of the Asian/Pacific Islander population, and an increase in the proportion of students 24 and older. Additionally, there was a statistically significant increase in the proportion of Black, non-Hispanics attaining associate degrees and/or bachelor's degrees. Recommendations for practice included suggesting that shareholders in subbaccalaureate CTE business programs have discussions about the current population being served by subbaccalaureate CTE business programs and determines whether efforts to encourage and recruit members from populations not currently being served should be made in order to diversify the population in this field of study.
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Nassar, Saif. "Evaluation of the Ohio CTE Device for Low Temperature Characterization of Hot Mix Asphalt." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1597158023589419.
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Phillips, Rhonda. "Choosing to Attend a Career Technical Center (CTC) in Ohio is a Choice - "Why Did Students Choose to Attend a CTC, and How Did Their Career Outcome Expectation Influence Their Decision To Attend?"." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1593041353706625.
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Cook, Carolyn M. "Impact of Chronic Traumatic Encephalopathy Information on Perceptions of Illness." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1562589809804291.
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Coelho, Pedro Manuel Rodrigues. "Análise do RCCTE no contexto da regulamentação europeia." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/5673.
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Dissertação apresentada na Faculdade de Ciências Tecnologia da Universidade Nova de Lisboa para obtenção do grau Mestre em Engenharia Civil – Perfil de ConstruçãoO sector da construção é um dos sectores com maior impacto na sociedade, apresen-tando uma elevada percentagem do consumo de energia no planeta. O seu desenvolvimento provocou alterações climáticas e esgotamento de alguns recursos naturais. Assim, é essencial dotar os edifícios, tanto os novos como os já existentes, de uma maior eficiência energética. Deste modo, é necessário adoptar medidas para um desenvolvi-mento mais sustentável, através da utilização de energia proveniente de fontes renováveis e da diminuição do seu consumo energético. Com a finalidade de resolver estes problemas, a directiva europeia relativa ao desem-penho energético dos edifícios (EPBD) sugere que os Estados Membros da União Europeia alterem os seus regulamentos térmicos de modo a reduzir o consumo energético nos edifícios. Este trabalho analisa o regulamento português (RCCTE) e o espanhol (CTE), tentando perceber as principais diferenças no processo de certificação de edifícios nos dois países.
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MÁGNO, Carlos. "Avaliação da disponibilidade de video surveillance as service (VSAAS)." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/17311.
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AVALIAÇÃO DA DISPONIBILIDADE DE VIDEO SURVEILLANCE AS A SERVICE (VSAAS) - CarlosMagno_vFinal_.pdf: 9082644 bytes, checksum: c59974ef3892ac2c00ead6db128cf7f6 (MD5)Made available in DSpace on 2016-07-11T12:45:47Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) AVALIAÇÃO DA DISPONIBILIDADE DE VIDEO SURVEILLANCE AS A SERVICE (VSAAS) - CarlosMagno_vFinal_.pdf: 9082644 bytes, checksum: c59974ef3892ac2c00ead6db128cf7f6 (MD5) Previous issue date: 2015-09-04
CNPq
Nos últimos anos, sistemas de Video Surveillance as a Service (VSaaS) apresentam um aumento significativo na demanda por técnicas de segurança que elevem os níveis de confiabilidade do serviço. Em paralelo, o paradigma de Computação em Nuvem tornou-se uma importante ferramenta para serviços remotos da computação. O VSaaS entrega armazenamento de grande quantidade de dados. Em 2012, 50% do armazenamento em big data que necessitou serem analisados foram de vídeo de vigilância. Em geral, os vídeos têm um alto significado para seus proprietários, não permitindo longos períodos de interrupção. Com o objetivo de evitar baixos desempenhos e ampliar a qualidade dos serviços de vídeo são necessários mecanismos para garantir alta disponibilidade em VSaaS. Entretanto, esta tarefa é difícil sem gerar impacto no custo. O presente trabalho propõe dois sistemas de VSaaS que foram submetidos a análise de disponibilidade, por meio de modelos analíticos (RBD, CTMC e SPN). O primeiro sistema, denominado doméstico, foi caracterizado pelos elementos essenciais para uma estrutura básica do VSaaS para ser utilizado em casas e pequenos comércios. Estes sistemas geraram três arquiteturas que foram modeladas para a obtenção de fórmulas fechadas, elas são importantes para realização de análises. O modelo da arquitetura 1 foi validado e as outras arquiteturas variaram dessas. A arquitetura 3 teve a maior disponibilidade entre as outras arquiteturas, por possuir a quantidade maior de componentes replicados. O downtime (em horas) desta arquitetura comparada com a sem replicações foi em 36,89%. Por ela ter a maior disponibilidade, foi realizada uma análise de sensibilidade que mostrou o componente “Node” como o de maior impacto. No segundo sistema, foi apresentado um VSaaS de uma empresa, chamado empresarial, gerando 18 (dezoito) arquiteturas, uma delas comparada a arquitetura A1 (sem redundância), obteve uma redução significativa do downtime de 30% com um pequeno aumento no custo na ordem de 7%. Caso um determinado serviço exija um downtime menor, outra análise apontou uma arquitetura com redução de 80% ao aumentar 30% do custo. Diante desse panorama foram propostas e analisadas arquiteturas que podem auxiliar administradores a tomar importantes decisões na implementação de VSaaS.
In the last few years, Video Surveillance as a Service VSaaS has shown the significant increase in demand for security mechanisms to ensure reliability higher levels. In parallel, the Cloud Computing paradigm has become an important tool for remote computing services. VSaaS, for example, allows for storage large amounts of data. In 2012, 50% of big data storage were surveillance video and in general, videos have a high significance for their owners, not allowing long periods interruption. To avoid video services with low performance and increase the quality, mechanisms to ensure high availability in VSaaS are required. However, this task is difficult without generating a major impact on cost, so this paper proposes two VSaaS systems who underwent an availability analysis, using analytical models (RBD, CTMC, and SPN). The first system, entitled domestic, was characterized by essential elements of a basic structure VSaaS, for use in homes and small businesses. This system generated three architectures that were modeled to obtain closed formulas; they are important to performing analyzes. The model architecture one was validated, and other architectures vary these. The architecture three had the highest availability of the other architectures, by owning the largest number of replicated components. The downtime (in hours) this architecture compared to a without replication was 36.89%. For having the highest availability, a sensitivity analysis showed the "Node"component as the most relevant. In the second system, was showed a VSaaS in a company and has generated eighteen architectures. One of them compared to a baseline, we obtained a significant reduction in downtime (30%) and a small increase in cost (on the order of 7%). In case, of the service requires less downtime, another analysis pointed an architecture with a reduction 80% of downtime and increased 30% in the cost. We propose and analyze architectures that can help administrators make important decisions in the VSaaS implementation.
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Ananthakrishnan, Shilpa. "P-type ATPases in Mycobacterium tuberculosis." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-theses/1200.
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"Tuberculosis is a deadly disease caused by bacteria of the genus Mycobacterium. One-third of the world’s population is infected with Mycobacterium tuberculosis. Two million these deaths occur each year in immunocompromised AIDS patients. M. tuberculosis has co-evolved with humans for many thousands of years. The bacillus has developed tactics to overcome the immune defense system and multiply in the macrophage. At the interface of the host and pathogen interactions, there is an interchange of metals and electrolytes. The host on one hand reduces the availability of metals essential for pathogen survival, like manganese and iron, in the macrophage and increases potassium ions which reduces pH in the phagolysosome. The host also generates Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), to create toxic affects through interactions with metals and metalloproteins. M. tuberculosis copes with the hostile environment in the macrophage by preventing the acidification of the phagolysosome, secreting antioxidant enzymes such as alkylhydroperoxidase (AhpF) and peroxiredoxin (AhpC), superoxide dismutase, SodA and SodC, and catalase KatG through the SecA system. M. tuberculosis contains 28 metal transporters, among them there are 12 unique P-type ATPases. This is an unusually high number of P-type ATPases in an organism. These ATPases transport several monovalent and divalent metals (Cu+, Cu2+, Ag+, Zn2+, Na+, K+, Ca2+, Cd2+, Pb2+, Mn2+, Mg2+, and Co2+) across biological membranes, using energy from ATP hydrolysis. Our analysis has revealed that these P-type ATPases have homologs in other intracellular symbiotic/pathogenic bacteria and certain chemolithotrophic archaea and bacteria. A corelation can hence be drawn among these pumps and the capability of surviving in noxious environments and coping with adverse redox conditions. Possible substrates were identified by determining the consensus sequences in different helices of these ATPases. However, out of the 12 P-type ATPases confirmed, transported substrate could be postulated for four of these proteins; CtpA, CtpB, CtpV and KdpB. Using bioinformatic approaches we have characterized the possible genetic environment of these genes. The transmembrane regions were analyzed for consensus sequences and the N-terminals and C-terminals were scrutinized for metal binding domains, and we were able to categorize these ATPases into P1 type and P2 type ATPases. In an attempt to determine the substrate specificity, two of these ATPases (CtpC and ctpG) were cloned and transformed into Escherichia coli cells. Cells expressing CtpC were grown in different concentrations of metals and pHs. In these experiments CtpC was found to show an interaction with copper and cadmium. Pure protein was obtained by His-tag purification and para-Nitro Phenol Phosphatase (pNPPase) assay was performed with different metals, it was found that copper and zinc activated the phosphatase activity of the enzyme; and cobalt and manganese were inhibitory. Inhibition of the pNPP assay could mean that there would be activation in the ATPase assay, meaning that cobalt and manganese could be possible substrates to this enzyme. "
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Paula, Márcia Regina Moraes de, and 92-981190232. "Uma abordagem de monitoramento, controle e medição de processos de negócios em tempo real: o caso do CTIC/UFAM." Universidade Federal do Amazonas, 2016. http://tede.ufam.edu.br/handle/tede/5763.
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Numerous events and fast changes in the business environment influence the operations of the companies and lead them to manage their real-time business processes. In this scenario, the monitoring, control and measurement practice of business processes gain importance, because business processes need to be monitored in real time, controlled through the substitution of manual processes by automated processes, and finally measured so that process performance indicators aid the decision-making process. To meet these challenges, this paper proposes an approach to measure performance indicators in real time. The research methodology was developed using action research from the perspective of participant observation to improve the process of availability of services of I.T. in the Information and Communications Technology Center of the Federal University of Amazonas. The main contribution of this paper was aimed at answering essential questions in the scope of the process through the environment visual control (visual management) to produce an appropriate situational awareness, establish metrics that align metrics with the process goals for decision making, allow knowledge about the resources used in the availability process, fundamental for the definition of capacity management strategies, and finally, automation, in order to avoid process failures, besides being used as base for process monitoring. In conclusion, this research succeeded in achieving its main goal, in view of the description of the approach and the positive application in the availability process maintained by the Infrastructure Coordination of the Information and Communication Technology Center of the Federal University of Amazon.
Numerosos eventos e rápidas mudanças no ambiente de negócios influenciam as operações das empresas e as levam à necessidade de gerenciar seus processos de negócio em tempo real. Dentro deste cenário, a prática de monitoramento, controle e medição de processos de negócio ganha importância, pois os processos de negócio precisam ser monitorados em tempo real, controlados através da substituição de processos manuais por processos automáticos, e, por último, medidos para que indicadores de desempenho de processo auxiliem o processo de tomada de decisão. Visando atender a estes desafios, o presente trabalho descreve uma abordagem de automação e de geração de indicadores de desempenho em tempo real. A pesquisa se desenvolveu dentro da metodologia de pesquisa-ação dentro da perspectiva da observação participante para melhoria de processo de disponibilidade de serviços de T.I. no Centro de Tecnologia da Informação e Comunicação da Universidade Federal do Amazonas. A contribuição da pesquisa visou responder perguntas centrais no âmbito do processo através do controle visual no ambiente (gestão à vista) para produção de uma consciência situacional apropriada, do alinhamento de métricas com os objetivos do processo para tomada de decisão, do conhecimento a respeito dos recursos empregados no processo de disponibilidade, fundamentais para a definição de estratégias de gerenciamento de capacidade, e, finalmente, da automação com o intuito de evitar falhas no processo, além de ser usada como base para o monitoramento do processo. Concluiu-se que a pesquisa conseguiu atingir o seu objetivo principal, tendo em vista a descrição da abordagem e a aplicação positiva no processo de disponibilidade mantido pela Coordenação de Infraestrutura do Centro de Tecnologia da Informação e Comunicação da Universidade Federal do Amazonas.
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Souza, Maria das Graças da Silva. "Melhoria nos processos de negócios do Centro de Tecnologia da Informação e Comunicação (CTIC) da Universidade Federal do Amazonas." Universidade Federal do Amazonas, 2016. http://tede.ufam.edu.br/handle/tede/5555.
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The current organizational context has led managers, both public and private, to rethink business processes. Integrate business processes with the use of available technologies can contribute to greater flexibility and speed in the execution of their operations. With the increasing demands it is difficult to ensure less time in producing a product or delivering a service without a proposal to improve these processes and without the use of proper tools that give conditions to promote such improvements. The objective of this research is to propose improvements in the coordination of Infrastructure Networks of Information Technology and Communication Center business processes (CTIC) of the Federal University of Amazonas, in dimensions quality, safety and availability. To achieve these objectives were carried out as well as meetings and interviews, field observation and document analysis. Brainstorming method to get the five critical processes, and methodology of hierarchical analysis process (AHP) to the choice of the two most critical process was applied. Performed a more refined analysis to understand the most critical points of these processes, such as bottlenecks, rework, redundancies, delays and waits, and identify whether there was a need to increase resources, and finally, the new flow of processes was built to the two processes, namely: network outage and services, and the availability of the SIE system. Using the Bizagi software it was proposed an interconnection of the new scheme with a monitoring tool. Finally, we presented the proposals for improvements through BPM and the processes of Infrastructure Coordination were therefore analyzed, mapped, redesigned and suggested improvement.
O atual cenário mundial tem levado os gestores a repensarem a maneira como os processos da organização são trabalhados. Desta forma, integrar os processos de negócios com o uso de tecnologias disponíveis, pode ser um grande aliado na promoção de maior flexibilidade e rapidez na execução de suas operações, pois com a concorrência cada vez mais acirrada, fica difícil garantir menor tempo na produção ou solução de determinado produto ou serviço sem uma proposta de melhoria desses processos e sem o uso de ferramentas adequadas que deem condições de promover essas melhorias. O objetivo desta pesquisa é propor melhorias nos processos de negócios da Coordenação de Infraestrutura de Redes do Centro de Tecnologia da Informação e Comunicação (CTIC) da Universidade Federal do Amazonas, nas dimensões qualidade, segurança e disponibilidade. Para atingir esses objetivos, foram realizadas reuniões e entrevistas, observação de campo, análise de documentação existente, coletas de evidências. Aplicado o método brainstorming para chegar aos cinco processos críticos, e a metodologia de análise hierárquica de processos (AHP) para a escolha dos dois processos mais críticos. Realizada uma análise mais refinada para entender os pontos mais críticos desses processos, tais como: gargalos, retrabalhos, redundâncias, atrasos e esperas, bem como identificar se havia necessidade de aumentar os recursos, e por último, foi construído o novo fluxo dos processos: Indisponibilidade de rede e serviços, e o de Indisponibilidade do sistema SIE, utilizando a ferramenta Bizagi com proporções à interligação do novo esquema a uma ferramenta de monitoramento. Concluiu-se que a pesquisa conseguiu atingir o seu objetivo principal, tendo em vista que foram apresentadas as propostas de melhorias através da BPM, os processos da Coordenação de Infraestrutura foram consequentemente analisados, mapeados, redesenhados e sugerida a sua melhoria.
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Horn, Anria. "The effect of a change in plastering technique on the rate of Major Surgery in Congenital Talipes Equinovarus(CTEV)." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/21745.
Full textAbstract:
The Ponseti technique of manipulation and casting is reported to have almost eliminated the need for extensive soft tissue release in the treatment of idiopathic clubfoot. This technique of treatment has however not been universally adopted and results of treatment vary significantly between treatment centres. Furthermore, surgical decision making in the treatment of clubfoot is currently largely based on clinical findings as opposed to radiographic parameters. The Ponseti method of manipulation and casting was introduced at our institution in 2002, prior to which we used the Kite method. Both prior to, and following the introduction of Ponseti casting, surgical decision making was based on pre-operative radiology, and intra-operative clinical assessment. We propose to determine the impact on this change of plastering technique on the rate of major surgery performed primarily in our patients with idiopathic clubfoot. We also aim to determine whether or not pre- operative radiographs have any bearing on the surgery performed on these patients.
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Almeida, Nuzyare Moura de. "A subrepresentação de mulheres no ingresso à educação superior brasileira em ciências, tecnologias, engenharias e matemática (CTEM) neste século." Master's thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/20704.
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Mestrado em Desenvolvimento e Cooperação InternacionalEste estudo visa a apresentar a evolução do ingresso de mulheres na educação superior brasileira em cursos nas áreas de Ciências, Tecnologias, Engenharias e Matemática (CTEM), no período de 2000 a 2018, com base em dados oficiais coletados anualmente através do Censo da Educação Superior. Também se buscou apresentar a realidade brasileira nesta seara, através de compromissos internacionalmente assumidos, de políticas públicas que integram "educação e gênero"/"educação e CTEM" e do envolvimento de outros atores e atrizes na defesa destes fatores estratégicos para o desenvolvimento, sobretudo em seu caráter humano. A incipiência da temática CTEM no mundo ainda é um obstáculo para a compreensão da necessidade de maior atenção à questão, associada à influência da ordem de gênero atualmente vigente na sociedade, sobretudo em seus aspectos individuais, familiares, escolares e socioculturais. As principais conclusões deste TFM evidenciam a subrepresentação feminina no ingresso ao ensino superior nas áreas do conhecimento socialmente consideradas mais "duras" e mais "adequadas" aos homens. Assim sucede fundamentalmente com as áreas de Tecnologia da Informação e Comunicação e Engenharias.
This study aims to present the evolution of the entry of women in Brazilian higher education in courses in the area of Science, Technology, Engineering, and Mathematics (STEM), from 2000 to 2018, based on official data collected annually through the Higher Education Census. It also sought to present the Brazilian reality in this field, through internationally assumed commitments, public policies that integrate "education and gender"/"education and STEM" and the involvement of other social agents in defense of education as a strategic development factor, mostly human-centered. The incipience of the STEM theme worldwide is still an obstacle for the understanding of the need of drawing greater attention to the issue, associated with the influence of a gender order currently in force in society, mainly in its individual, familiar, educational and socio-cultural aspects. The main conclusions in this study put in evidence the female underrepresentation in entering higher education in areas of knowledge that are socially considered "hard" and more "appropriate" for men. It is the case in the areas of Information and Communication Technology and Engineering.
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CARVALHO, Marilda Nascimento. "Processo de Remoção de Compostos Btex e Fenol Por Adsorção Multicomponente Em Argilas Organicamente Modificadas." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/11882.
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A contaminação da água por compostos orgânicos tóxicos é uma das maiores preocupações ambientais e tem aumentado o interesse na busca de adsorventes eficientes para a remoção desses compostos. A adsorção utilizando argilas constitui uma das tecnologias de aplicação crescentes empregadas no tratamento secundário de efluentes contaminados por compostos orgânicos de origem na indústria de petróleo. Este trabalho investigou um processo de adsorção dos compostos orgânicos benzeno, tolueno, etilbenzeno, xilenos (BTEX) e do fenol presentes em soluções aquosas em baixas concentrações, até 20 mg/L, por meio de uma argila esmectítica (chocolate) de origem do estado da Paraíba, no nordeste do Brasil, visando colaborar com tecnologias de caráter sustentável, para a indústria de petróleo e petroquímica. A argila organofílica foi sintetizada a partir do sal quaternário (SQA) cloreto de hexadeciltrimetilamônio na concentração de 150% da capacidade de troca catiônica (CTC) da argila, a qual promoveu o aumento do espaçamento basal da estrutura cristalina do argilomineral de 14,73 Å para 22,08 Å. Procedeu-se à avaliação de sistemas de adsorção multicomponente, em regime descontínuo, considerando as abordagens cinéticas e de equilíbrios. Os teores dos componentes BTEX e fenol foram quantificados por cromatografia líquida de alta eficiência (CLAE). Os resultados experimentais ajustaram-se bem ao modelo de equilíbrio combinado de Langmuir-Freundlich e revelaram capacidades máximas de adsorção entre 1,27mg/g (tolueno) a 8,28mg/g (fenol) e cinéticas de equilíbrio em torno de 30 minutos. Parâmetros relacionados à heterogeneidade superficial da argila indicaram a existência de sítios ativos específicos. As afinidades de adsorção de BTEX e de fenol pela argila organofílica no sistema multicomponente apresentaram-se na ordem decrescente: etilbenzeno > xilenos > tolueno > fenol > benzeno. Estas afinidades estiveram relacionadas ao tamanho das moléculas dos aromáticos. As eficiências de remoção obtidas variaram em torno de 55% e 90%.
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Bjärmark, Joakim, and Marco Strandberg. "Hardware Accelerator for Duo-binary CTC decoding : Algorithm Selection, HW/SW Partitioning and FPGA Implementation." Thesis, Linköping University, Department of Electrical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7902.
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Wireless communication is always struggling with errors in the transmission. The digital data received from the radio channel is often erroneous due to thermal noise and fading. The error rate can be lowered by using higher transmission power or by using an effective error correcting code. Power consumption and limits for electromagnetic radiation are two of the main problems with handheld devices today and an efficient error correcting code will lower the transmission power and therefore also the power consumption of the device.
Duo-binary CTC is an improvement of the innovative turbo codes presented in 1996 by Berrou and Glavieux and is in use in many of today's standards for radio communication i.e. IEEE 802.16 (WiMAX) and DVB-RSC. This report describes the development of a duo-binary CTC decoder and the different problems that were encountered during the process. These problems include different design issues and algorithm choices during the design.
An implementation in VHDL has been written for Alteras Stratix II S90 FPGA and a reference-model has been made in Matlab. The model has been used to simulate bit error rates for different implementation alternatives and as bit-true reference for the hardware verification.
The final result is a duo-binary CTC decoder compatible with Alteras Stratix II designs and a reference model that can be used when simulating the decoder alone or the whole signal processing chain. Some of the features of the hardware are that block sizes, puncture rates and number of iterations are dynamically configured between each block Before synthesis it is possible to choose how many decoders that will work in parallel and how many bits the soft input will be represented in. The circuit has been run in 100 MHz in the lab and that gives a throughput around 50Mbit with four decoders working in parallel. This report describes the implementation, including its development, background and future possibilities.
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Carneiro, João Bosco Leão. "Gestão do conhecimento no ambiente de Tecnologia da Informação da Universidade Federal do Amazonas: estudo de caso do CTIC/UFAM." Universidade Federal do Amazonas, 2016. http://tede.ufam.edu.br/handle/tede/5536.
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Initially in the so-called Post-Industrial Era or the Age of Knowledge, organizations began to take a different view of their intangible assets. This development stemmed from the realization that more important than facilities, equipment and technology are the people, the organization’s human resources. And their importance comes not only from the work they do, but, above all, from the knowledge they possess. Since tacit knowledge is inherent to learning and to practice, it cannot be displayed without the express desire of those who possess it. Within this new context, Knowledge Management (KM) has emerged to put into practice ways of making knowledge a management object, not only to be used as a measure of competitive difference, but to adapt to today’s increasingly dynamic scenario. In consequence, a case study is presented that discusses KM in the sector responsible for Information and Communications Technology (ICT) within a Federal Institution of Higher Education. Firstly, a survey was done of the sector’s current situation (structure, technology and human resources) and the possible relationship to KM; a parallel is then drawn between existing knowledge and needs, followed by a description of an IT tool compatible with a KM initiative; finally, based on the information collected in the previous steps, an evaluation is presented of the existing knowledge potential as well as its contribution to the research site’s activities.
A partir da chamada Era Pós-industrial ou Era do Conhecimento, as organizações passaram a olhar com outros olhos seus bens intangíveis. Isso decorreu da constatação de que mais importante que instalações, equipamentos e tecnologia são as pessoas, os recursos humanos da organização. E essa importância não decorre só do trabalho que as pessoas realizam, mas, principalmente, do conhecimento que elas carregam consigo. Uma vez que o conhecimento tácito é inerente ao aprendizado e a prática, ele não pode ser externalizado sem que aquele que o possui deseje. Dentro dessa nova realidade, surgiu a Gestão do Conhecimento (do termo em inglês knowledge management - KM), para pôr em prática formas de tornar o conhecimento um objeto de gestão e de utilizá-lo como um meio de diferenciação em relação não só à concorrência, mas para adaptar-se ao cenário cada vez mais dinâmico da atualidade. Em função disso, esta pesquisa, na forma de estudo de caso, traz à discussão a Gestão do Conhecimento no órgão responsável pela Tecnologia da Informação e Comunicação (TIC) em uma Instituição Federal de Ensino Superior. Em primeiro lugar, realizou-se um levantamento da situação atual do órgão (estrutura, tecnologia e recursos humanos) e a possível relação com a Gestão do Conhecimento; em seguida é traçado um paralelo entre o conhecimento existente e as necessidades; a seguir é apresentada uma ferramenta de TI compatível com uma iniciativa de GC e, finalmente, a partir de informações coletadas nas etapas anteriores é apresentada uma avaliação do potencial de conhecimento existente, assim como sua contribuição às atividades do local da pesquisa.
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MURATA, YOKO. "Sintese e caracterizacao do hormonio tireotrofico humano recombinante (rec-hTSH) contendo uma sub unidade beta quimerica (rec-hTSHbeta-CTEP hCGbeta)." reponame:Repositório Institucional do IPEN, 1995. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10432.
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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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Hedin, Niklas. "NMR studies of complex fluids and solids formed by surfactants." Doctoral thesis, KTH, Chemistry, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3033.
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NMR methods have been designed and employed in studying ofcomplex liquids and solids formed by surfactants. PGSE NMRexperiments are easily biased by convection; this artifact canbe avoided by changing the sample holder and by usingconvection-compensated pulse sequences. The temperaturedistribution within samples was controlled using thetemperature dependent order parameter for CBr2H2dissolved in a thermotropic nematic solvent.Electronic ringing that often spoils accurate NMR experimentsfor broad lines was removed by the using composite pulses andquadrupole echo sequences with appropriate phase cycles.
Field-dependent81Br and35Cl NMR relaxation studies in micellar solutions ofC16TAX surfactants showed that the structure ordynamics of the hydration shell is more influenced by thesurfactant cation for bromide than for chloride, in agreementwith their position in the Hoffmeister series. The presence ofa small but significant frequency-dependent relaxation showedthat the lateral self diffusion of the anions may be reduced ascompared to its bulk value in diluted solutions but only with afactor of 1.0 - 2.5. The ions are clearly not "bound" to thesurface. A field-dependent2H NMR relaxation study on the CTABr-α-d2and benzene-d6showed an initial one-dimensional micellargrowth followed by the appearance of microemulsion droplets onaddition of benzene. The local mobility of the benzene wasreduced when solubilized in small amounts, consistent with aninitial average location of benzene at the micellar interface.The surfactant diffusion coefficients fromconvection-compensated PGSE NMR experiments in the C12E8-D2O system showed monotonous growth of the micellesupon increasing temperature. Emulsion droplets in the C12E5-decane-D2O system where shown to coarsen according to theOstwald ripening theory after being brought out of equilibriumby a temperature drop. X-ray scattering and2H NMR line-shape and relaxation experimentssuggested that complex solids formed by a partly-sulfatedpolysaccharide and CnTAB exhibit regular ordering at both microscopicand mesoscopic length scales.
Keywords: CTAB, CTAC, C12E8, C12E5, decane, benzene, CBr2H2, polysaccharide, micelle, microemulsion, emulsion,Ostwald ripening, NMR,81Br,35Cl,2H, field- dependent spin relaxation, PGSE, selfdiffusion, convection, ringing, thermometer, generalized Blochequations, EXORCYCLE, quadrupole echo, SAXS, WAXS, cryo-TEM.
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Cameron, Juliet Dallas. "Investigation of the mechanical and structural properties of cellulose tricarbanilate/polymethylacrylate blends." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/571.
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Odeh, Awatef. "Identification of platelet activating factor (PAF) receptor in equine spermatozoa and its role in motility, capacitation and the acrosome reaction." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/29337.
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Platelet activating factor (PAF) is a unique signaling phospholipid that has many biologic properties in addition to platelet activation. PAF roles in reproduction involve ovulation, fertilization, embryo development, implantation and parturition. It may also serve as a biomarker for normal sperm function. The presence of PAF receptor on the spermatozoa of 10 stallions was investigated by immunofluorescence microscopy. Statistical analysis revealed that the fluorescence intensity, FI (Mean+/-SEM), in the post- acrosomal region (FI= 2.60+/-0.15) was significantly higher (P< 0.01) than that in any other region of stallion spermatozoa. The effect of synthetic PAF on stallion spermatozoal motility, capacitation, and the acrosome reaction (AR) were evaluated. Treatment of 10 stallion semen samples with 10 â 4 to 10 â 13 M PAF resulted in statistically significant differences in motility and capacitation (r2 = 0.81 and 0.83 respectively). The concentration of PAF, incubation time and their interaction were highly significant (P< 0.01) for their effect on motility. Concentrations of PAF ranging from 10-9 to10-11 M were able to induce capacitation. Following capacitation in vitro with PAF, and induction of the acrosomal reaction by progesterone, transmission electron microscopy (TEM) was conducted on the spermatozoa of 3 stallions, to detect the true AR. Differences in PAF concentrations were highly significant as indicated by R-square (for intact: 97.2, reacted: 89.8, and for vesiculated: 98.1). Treating spermatozoa from 3 stallions with the PAF antagonist FR-49175 inhibited calcium release and fluorescence intensity with a median inhibitory concentration (IC50) of 10-7.5 M (r2=0.82, P<0.01) and 10-8 M (r2=0.92, P<0.01) respectively, suggesting a receptor mediated process for the mechanism of action of PAF. Although the exact mechanisms of PAF action on equine spermatozoa remain unclear, it is widely reported that PAF acts by a receptor-mediated mechanism and that the PAF receptor is a member of the family of G-protein coupled receptors with phospholipase C as the effector. Since the limited success in equine ART (e.g. IVF) is in part due to lack of efficient treatment of stallion spermatozoa for capacitation, PAF may be useful to help capacitate stallion spermatozoa. Without proper capacitation, spermatozoa are unable to initiate the acrosome reaction which is a prerequisite for fertilization.Ph. D.
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Qin, Xian. "Compliant copper microwire arrays for reliable interconnections between large low-CTE packages and printed wiring board." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53532.
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The trend to high I/O density, performance and miniaturization at low cost is driving the industry towards shrinking interposer design rules, requiring a new set of packaging technologies. Low-CTE packages from silicon, glass and low-CTE organic substrates enable high interconnection density, high reliability and integration of system components. However, the large CTE mismatch between the package and the board presents reliability challenges for the board-level interconnections. Novel stress-relief structures that can meet reliability requirements along with electrical performance while meeting the cost constraints are needed to address these challenges. This thesis focuses on a comprehensive methodology starting with modeling, design, fabrication and characterization to validate such stress-relief structures. This study specifically explores SMT-compatible stress-relief microwire arrays in thin polymer carriers as a unique and low-cost solution for reliable board-level interconnections between large low-CTE packages and printed wiring boards.
The microwire arrays are pre-fabricated in ultra-thin carriers using low-cost manufacturing processes such as laser vias and copper electroplating, which are then assembled in between the interposer and printed wiring board (PWB) as stress-relief interlayers. The microwire array results in dramatic reduction in solder stresses and strains, even with larger interposer sizes (20 mm × 20 mm), at finer pitch (400 microns), without the need for underfill. The parallel wire arrays result in low resistance and inductance, and therefore do not degrade the electrical performance. The scalability of the structures and the unique processes, from micro to nanowires, provides extendibility to finer pitch and larger package sizes.
Finite element method (FEM) was used to study the reliability of the interconnections to provide guidelines for the test vehicle design. The models were built in 2.5D geometries to study the reliability of 400 µm-pitch interconnections with a 100 µm thick, 20 mm × 20 mm silicon package that was SMT-assembled onto an organic printed wiring board. The performance of the microwire array interconnection is compared to that of ball grid array (BGA) interconnections, in warpage, equivalent plastic strain and projected fatigue life.
A unique set of materials and processes was used to demonstrate the low-cost fabrication of microwire arrays. Copper microwires with 12 µm diameter and 50 µm height were fabricated on both sides of a 50 µm thick, thermoplastic polymer carrier using dryfilm based photolithography and bottom-up electrolytic plating. The copper microwire interconnections were assembled between silicon interposer and FR-4 PWB through SMT-compatible process. Thermal mechanical reliability of the interconnections was characterized by thermal cycling test from -40°C to 125°C. The initial fatigue failure in the interconnections was identified at 700 cycles in the solder on the silicon package side, which is consistent with the modeling results. This study therefore demonstrated a highly-reliable and SMT-compatible solution for board-level interconnections between large low-CTE packages and printed wiring board.
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Silva, Luciano Lopes. "Sorção e mobilidade do ametryn em latossolos com diferentes características físicas e químicas." Universidade Federal de Viçosa, 2009. http://locus.ufv.br/handle/123456789/5437.
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Previous issue date: 2009-12-21Conselho Nacional de Desenvolvimento Científico e Tecnológico
The objective of this work was to evaluating the sorption and mobility of Ametryn in four types of soils [Red-Yellow Latosol (LVA), Humic Red-Yellow Latosol (LVAh), Red Latosol (LV) and Yellow Latasol (LA)], at different pH values. For such, samples of these soils were collected at the depth of 0-20 cm and characterized physically and chemically. Acid neutralization curves were generated for each soil. Shortly after, it was performed the correction of soil acidity (for LVA, LVAh and LV), at pH values close to 6,0. LA was evaluated only at pH 6,3. Before implanting the study on ametryn mobility, preliminary assays were carried out, one for each soil, aiming at determining the herbicide dose which inhibits by 50% the accumulation of dry matter by the aerial part of cucumber plants (Cucumis sativus), used as indicator species. Based on the data achieved, it was calculated the ametryn sorption ratio in the soils in relation to the inert substrate. The following sequence of sorption ratio in the soils was observed: LVAh sc > LVA sc > LVA cc > LVAh cc > LV sc > LA sc > LV cc (cc = with acidity correction; sc = without acidity correction). To evaluate ametryn mobility, PVC columns were used, with 10 cm of diameter and 50 cm of length. They were duly prepared and filled with the respective soils, and 4,0 kg ha-1 of ametryn were applied to the top of these columns. Twelve hours after herbicide application, a rain of 60 mm was simulated. After 72 hours, the columns were opened longitudinally andplaced in the horizontal position. The indicator species was sown along the columns for the assessment of ametryn mobility in the soils. The experiment was carried out in a completely randomized design, in split plot, with four replications. The experiment was composed of 70 treatments - seven substrates and ten segments (development of the indicator plants in the substrates of the columns at the depths of 0-5, 5-10, 10-15,15-20, 20-25, 25-30, 30-35, 35-40, 40-45 and 45-50 cm). Besides, a control without herbicide was used for each soil. It was concluded that the lowest ametryn mobilities occurred in soils with higher contents of clay and CTC, and that liming favored ametryn mobility in the soils investigated.
Objetivou-se com este trabalho avaliar a sorção e a mobilidade do ametryn em quatro tipos de solos [Latossolo Vermelho-Amarelo (LVA), Latossolo Vermelho- Amarelo Húmico (LVAh), Latossolo Vermelho (LV) e Latassolo Amarelo (LA)], com valores de pH natural e corrigido. Para isso, amostras destes solos foram coletadas à profundidade de 0-20 cm, caracterizadas física e quimicamente e, geradas curvas de neutralização de acidez para cada um dos solos. Logo após foi realizada a correção de acidez dos solos (LVA, LVAh e LV), a valores de pH próximos a 6,0. O LA foi avaliado apenas no valor de pH 6,3. Antes da implantação do estudo de mobilidade do ametryn foram realizados ensaios preliminares, um para cada solo, visando determinar a dose do herbicida que inibe em 50% o acúmulo de matéria seca pela parte área das plantas de pepino (Cucumis sativus), utilizadas como espécie indicadora. A partir dos dados obtidos foi calculada a razão de sorção do ametryn nos solos em relação ao substrato inerte. Constatou-se a seguinte sequência de razão de sorção nos solos:LVAh sc > LVA sc > LVA cc > LVAh cc > LV sc > LA sc > LV cc (cc = com correção da acidez; sc = sem correção da acidez). Para a avaliação da mobilidade do ametry nutilizou-se colunas de PVC de 10 cm de diâmetro por 50 cm de comprimento, devidamente preparadas e enchidas com os respectivos solos. No topo dessas colunas foi aplicado o ametryn, na dose de 4,0 kg ha-1 . Doze horas após a aplicação do herbicida fez-se a simulação de uma chuva de 60 mm. Após 72 horas as colunas foram abertas longitudinalmente, colocadas na posição horizontal, sendo semeadas ao longo delas a espécie indicadora para se avaliar a mobilidade do ametryn nos solos. O experimento foi realizado em delineamento inteiramente casualizado em esquema de parcelas subdivididas, com quatro repetições. O experimento foi composto por 70 tratamentos sendo sete tipos de solos e 10 segmentos (desenvolvimento das plantas indicadoras nos substratos das colunas nas profundidades de 0-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45 e 45-50 cm). Em complementação, foi utilizada uma testemunha sem herbicida para cada solo. Concluiu-se que menores mobilidades do ametryn ocorreram em solos com maiores teores de argila e de CTC, e que a calagem favoreceu a mobilidade do ametryn nos solos estudados.