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1

Mestres, Carlos-A., Ramón Cartaña, Manuel Castella, Jaime Mulet, and José L. Pomar. "Ascending Aorta to Femoral Bypass with Cryopreserved Vascular Homografts." Asian Cardiovascular and Thoracic Annals 3, no. 2 (June 1995): 90–92. http://dx.doi.org/10.1177/021849239500300216.

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Homograft vascular replacement is almost as old as vascular surgery itself. Gross and Dubost are credited as the first authors who clinically attempted vascular reconstruction using biological tissue of human origin. The advent of synthetic vascular prostheses together with the complexity of logistics in procuring, preserving, and storing vascular homografts made the routine use of vascular homografts impractical. Cryopreservation techniques have strongly influenced the use of biological tissue. The tireless work of a few authors has enabled us to better understand the behavior of homograft tissues in cardiovascular surgery. Homograft replacement of the aortic and pulmonary valves is now a recognized way to treat a number of conditions of the aortic root and the right ventricular outflow tract. Renewed interest in the use of cryopreserved homografts in cardiac surgery has led us to expand our own indications for their use. As our Cryopreservation Unit is fully operative, we also have vascular homografts available for implantation. Here we describe the extended use of vascular homografts in extraanatomic aortic bifurcation bypass in a patient with previous multiple vascular operations. To use the ascending aorta as the inflow source in cardiovascular reconstruction has been previously described; however, it has not been popular among surgeons. Robicsek termed this type of bypass graft “very long” aortic grafts, and we recently had the chance to use fully biological tissue of human origin for this type of reconstruction.
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2

Bisdas, Mattner, Ott, Pichlmaier, Wilhelmi, Haverich, and Teebken. "Significance of infection markers and microbiological findings during tissue processing of cryopreserved arterial homografts for the early postoperative course." Vasa 38, no. 4 (November 1, 2009): 365–73. http://dx.doi.org/10.1024/0301-1526.38.4.365.

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Background: To evaluate homograft implantation for the urgent treatment of vascular infections on the basis of the course of infection using microbiological findings in perioperatively obtained specimens and during homograft processing. Patients and methods: 85 patients were treated with cryopreserved homografts from 2004-2007. The microbiological findings of the decontamination process of homografts in the tissue bank were evaluated. The perioperative infection profile (microorganisms, CRP, leukocytes, body temperature) of the patients was analysed. Results: Complete microbiological and clinical follow-up for the postoperative course was available for 35 patients, who were treated with homografts from the same tissue bank and finally included into this study. 55 cryopreserved homografts were implanted. 35 / 55 (64 %) homografts were positive for microorganisms before decontamination. 3 / 35 (9 %) homografts remained positive after the decontamination. 33 patients were operated for prosthetic graft infection and 2 for an infiltration of a large vessel from neighbouring malignant disease. The most common infection agent was Staphylococcus aureus. Thirty-day mortality was 20 % (7 / 35). Only in 4 / 35 (11 %) patients were the microorganisms of the intraoperative swabs also detected during the postoperative course. The microorganisms were ORSA, Enterococcus faecium, Enterobacter aerogenes and Burkholderia cepacia. The patient with ORSA infection died on POD 11 from multiple organ failure and all other patients recovered. None of the postoperative swabs showed the homograft predecontamination microorganisms. Interestingly, a significant association (P = 0.003) between C-reactive protein increase two weeks after surgery and donor-recipient ABO mismatch was found. Conclusions: The implantation of homografts following the established decontamination is an alternative urgent therapeutic option in vascular infections with encouraging outcomes. The absence of the predecontamination focus in the postoperative specimens of patients, suggests that the postoperative course and outcomes show no strong relation to potential homograft contamination prior to the decontamination process.
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3

Almassi, G. Hossein. "Cryopreserved Pulmonary Homograft." Journal of Cardiac Surgery 7, no. 2 (June 1992): 192. http://dx.doi.org/10.1111/j.1540-8191.1992.tb00798.x.

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4

Butany, Jagdish, Manmeet S. Ahluwalia, Vidhya Nair, and Tirone E. David. "Cryopreserved pulmonary homograft." Cardiovascular Pathology 13, no. 1 (January 2004): 59–61. http://dx.doi.org/10.1016/s1054-8807(03)00092-9.

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5

Schroeder, Meierling, Riepe, Braun, and Imig. "Behandlung einer aortobifemoralen Protheseninfektion durch Rekonstruktion mit kryokonservierten homologen Arterien aus der European Homograft Bank." Vasa 28, no. 1 (February 1, 1999): 42–45. http://dx.doi.org/10.1024/0301-1526.28.1.42.

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The excision of an infected aortobifemoral Dacron graft 9 years after implantation and bilateral axillofemoral Dacron bypass reconstruction led to reinfection of the extra-anatomic bypass grafts. A new aorto-bifemoral reconstruction was performed using cryopreserved homografts delivered by the European Homograft Bank in Brussels and both axillo-femoral prostheses were removed. No signs of infection and no alterations of the homografts can be detected 3 years later.
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6

Tan, Christian H., David C. Cleveland, Robert J. Dabal, Luz A. Padilla, Kathryn S. Maxwell, Mark A. Law, Waldemar F. Carlo, Santiago Borasino, and Robert A. Sorabella. "Association Between Venous Homografts and Allosensitization After Norwood Procedure." World Journal for Pediatric and Congenital Heart Surgery 14, no. 1 (January 2023): 25–30. http://dx.doi.org/10.1177/21501351221120411.

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Background Right ventricle (RV) to pulmonary artery (PA) shunts have become the shunt of choice at many centers for use during the Norwood procedure for single ventricle palliation. Some centers have begun to use cryopreserved femoral or saphenous venous homografts as an alternative to polytetrafluoroethylene (PTFE) for shunt construction. The immunogenicity of these homografts is unknown, and potential allosensitization could have significant implications on transplant candidacy. Methods All patients undergoing Glenn procedure at our center between 2013 and 2020 were screened. Patients who initially underwent Norwood procedure with either PTFE or venous homograft RV-PA shunt and had available pre-Glenn serum were included in the study. The primary outcome of interest was panel reactive antibody (PRA) level at the time of Glenn surgery. Results Thirty-six patients met inclusion criteria (N = 28 PTFE, N = 8 homograft). Patients in the homograft group had significantly higher median PRA levels at the time of Glenn surgery (0% [IQR 0-18] PTFE vs 94% [IQR 74-100] homograft, P = .003). There were no other differences between the two groups. Conclusions Despite potential improvements in PA architecture, the use of venous homografts for RV-PA shunt construction at the time of Norwood procedure is associated with significantly elevated PRA level at the time of Glenn surgery. Centers should carefully consider the use of currently available venous homografts given the high percentage of these patients who may require future transplantation.
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7

Yanagawa, Bobby, Amine Mazine, Derrick Y. Tam, Peter Jüni, Deepak L. Bhatt, Stephen Spindel, John D. Puskas, Subodh Verma, and Jan O. Friedrich. "Homograft versus Conventional Prosthesis for Surgical Management of Aortic Valve Infective Endocarditis." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 3 (May 2018): 163–70. http://dx.doi.org/10.1097/imi.0000000000000510.

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Objective Surgical management of aortic valve infective endocarditis (IE) with cryopreserved homograft has been associated with lower risk of recurrent IE, but there is equipoise with regard to the optimal prosthesis. This systematic review and meta-analysis were performed to compare outcomes between homograft and conventional prosthesis for aortic valve IE. Methods We searched MEDLINE database to September 2017 for studies comparing homograft versus conventional prosthesis. The main outcomes were all-cause mortality, recurrent IE, and reoperation. Results There were 18 included comparative observational studies with 2232 patients (median follow up = 5 [interquartile range: 2–7] years, 30% prosthetic valve endocarditis); four studies were adjusted for baseline differences. There were no differences in perioperative mortality or stroke despite a greater proportion of staphylococcal endocarditis, abscess, and root replacements but less multivalve involvement in the homograft group. Long-term outcomes of all-cause mortality [incidence rate ratio (IRR) = 1.03, 95% confidence interval (CI) = 0.81–1.31, P = 0.83, for unmatched, and IRR = 0.82, 95% CI = 0.36–1.84, P = 0.63, for matched studies], recurrent endocarditis (IRR = 1.01, 95% CI = 0.53–1.93, P = 0.96, for unmatched, and IRR = 1.04, 95% CI = 0.49–2.19, P = 0.92, for matched studies), and reoperation (IRR = 1.60, 95% CI = 0.80–3.21, P = 0.18, for unmatched, and IRR = 3.17, 95% CI = 0.52–19.44, P = 0.21, for matched studies) were not different comparing homograft versus conventional prosthesis. There was a significantly increased need for reoperation with homograft versus mechanical prosthetic valves, but this comparison was based on limited data. Conclusions Homografts and conventional prostheses offer similar survival and freedom from recurrent endocarditis and reoperation for aortic valve IE. Homografts may be associated with greater risk of reoperation compared with mechanical valves.
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8

Motomura, N. "A study of cryopreserved human homograft." Japanese Journal of Cardiovascular Surgery 19, no. 6 (1990): 1307–9. http://dx.doi.org/10.4326/jjcvs.19.1307.

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9

Vogt, Paul, Miralem Pasic, Ludwig von Segesser, Thierry Carrel, and Marko Turina. "Cryopreserved aortic homograft for mycotic aneurysm." Journal of Thoracic and Cardiovascular Surgery 109, no. 3 (March 1995): 589–91. http://dx.doi.org/10.1016/s0022-5223(95)70294-6.

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10

Barili, Fabio, Luca Dainese, Anna Guarino, Paolo Biglioli, and Gianluca Polvani. "The Challenge of Homograft Tissue Banks: The Viability of Cryopreserved Valvular Homografts." Journal of Heart and Lung Transplantation 26, no. 9 (September 2007): 964–65. http://dx.doi.org/10.1016/j.healun.2007.07.005.

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11

Botta, L., G. Kloppenburg, and A. Yilmaz. "Intramural Hematoma of a Cryopreserved Aortic Homograft." Thoracic and Cardiovascular Surgeon 56, no. 07 (September 22, 2008): 426–28. http://dx.doi.org/10.1055/s-2007-989493.

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12

Grinda, J. M., R. Zegdi, R. Leroux, and A. Deloche. "Tricuspid bioprosthesis replacement with cryopreserved mitral homograft." European Journal of Cardio-Thoracic Surgery 21, no. 4 (April 2002): 763–64. http://dx.doi.org/10.1016/s1010-7940(02)00027-1.

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13

Soquet, Jérôme, Jean-Pierre Chambon, Yves Goffin, and Ramadan Jashari. "Acute rejection of a cryopreserved arterial homograft." Cell and Tissue Banking 16, no. 3 (December 16, 2014): 331–33. http://dx.doi.org/10.1007/s10561-014-9489-y.

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14

Ditkowski, Bartosz, Kirsten Leeten, Ramadan Jashari, Elizabeth Jones, and Ruth Heying. "Staphylococcus aureus adheres avidly to decellularised cardiac homograft tissue in vitro in the fibrinogen-dependent manner." Cardiology in the Young 30, no. 12 (September 21, 2020): 1783–87. http://dx.doi.org/10.1017/s1047951120002772.

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AbstractObjective:Infective endocarditis remains a severe complication associated with a high morbidity and mortality in patients after heart valve replacement. Exploration of the pathogenesis is of high demand and we, therefore, present a competent model that allows studying bacterial adherence and the role of plasma fibrinogen in this process using a new in-house designed low-volume flow chamber. Three cardiac graft tissues used for pulmonary valve replacement have been tested under shear conditions to investigate the impact of surface composition on the adhesion events.Methods:Tissue pieces of cryopreserved homograft (non-decellularised), decellularised homograft and bovine pericardium patch were investigated for fibrinogen binding. Adherence of Staphylococcus aureus to these graft tissues was studied quantitatively under flow conditions in our newly fabricated chamber based on a parallel plates’ modality. The method of counting colony-forming units was reliable and reproducible to assess the propensity of different graft materials for bacterial attachment under shear.Results:Bacterial perfusions over all plasma-precoated tissues identified cryopreserved homograft with the lowest affinity for S. aureus compared to decellularised homograft presenting a significantly higher bacterial adhesion (p < 0.05), which was linked to a more avid fibrinogen binding (p < 0.01). Bovine pericardial patch, as a reference tissue in this study, was confirmed to be the most susceptible tissue graft for the bacterial adhesion, which was in line with our previous work.Conclusion:The two studied homograft tissues showed different levels of bacterial attachment, which might be postulated by the involvement of fibrinogen in the adhesion mechanism(s) shown previously for bovine tissues.
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15

Bailey, Warren W. "Cryopreserved Pulmonary Homograft Valved External Conduits: Early Results." Journal of Cardiac Surgery 2, no. 1S (March 1987): 199–204. http://dx.doi.org/10.1111/jocs.1987.2.1s.199.

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16

Chiu, Kuan-Ming, Tzu-Yu Lin, Jer-Shen Chen, Shao-Jung Li, and Shu-Hsun Chu. "Tricuspid valve replacement with a cryopreserved pulmonary homograft." Journal of Thoracic and Cardiovascular Surgery 130, no. 5 (November 2005): e1-e2. http://dx.doi.org/10.1016/j.jtcvs.2005.07.022.

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17

Légaré, Jean Francois, and David B. Ross. "Pathology of fresh versus cryopreserved homograft heart valves." Journal of Thoracic and Cardiovascular Surgery 127, no. 6 (June 2004): 1850–51. http://dx.doi.org/10.1016/s0022-5223(03)00597-x.

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18

Olivito, Silvio, Stéphanie Lalande, Francesco Nappi, Nadjib Hammoudi, Cosimo D’Alessandro, Pierre Fouret, and Christophe Acar. "Structural deterioration of the cryopreserved mitral homograft valve." Journal of Thoracic and Cardiovascular Surgery 144, no. 2 (August 2012): 313–20. http://dx.doi.org/10.1016/j.jtcvs.2011.06.041.

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19

Grinda, Jean-Michel, Jean-Luc Mainardi, Nicola D'Attellis, Marie-Odile Bricourt, Alain Berrebi, Jean-Noël Fabiani, and Alain Deloche. "Cryopreserved Aortic Viable Homograft for Active Aortic Endocarditis." Annals of Thoracic Surgery 79, no. 3 (March 2005): 767–71. http://dx.doi.org/10.1016/j.athoracsur.2004.08.013.

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20

Desai, Manan H., Pranava Sinha, Richard A. Jonas, and Karthik Ramakrishnan. "Modified Yasui Operation Using Cryopreserved Femoral Vein Homograft." Annals of Thoracic Surgery 110, no. 2 (August 2020): e147-e149. http://dx.doi.org/10.1016/j.athoracsur.2020.02.031.

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21

Acar, Christophe, Arnaud Farge, Ahmad Ramsheyi, Juan-Carlos Chachques, Serban Mihaileanu, Roger Gouezo, Jean Gerota, and Alain F. Carpentier. "Mitral valve replacement using a cryopreserved mitral homograft." Annals of Thoracic Surgery 57, no. 3 (March 1994): 746–48. http://dx.doi.org/10.1016/0003-4975(94)90582-7.

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22

Shrestha, Bishwo M. S., Satsuki Fukushima, Marian Vrtik, Ian H. Chong, Lisa Sparks, Homayoun Jalali, and Peter G. Pohlner. "Partial Replacement of Tricuspid Valve Using Cryopreserved Homograft." Annals of Thoracic Surgery 89, no. 4 (April 2010): 1187–94. http://dx.doi.org/10.1016/j.athoracsur.2009.12.047.

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23

Kunachak, Somyos, Boonchu Kulapaditharom, Yongyudh Vajaradul, and Mana Rochanawutanon. "Cryopreserved, Irradiated Tracheal Homograft Transplantation for Laryngotracheal Reconstruction in Human Beings." Otolaryngology–Head and Neck Surgery 122, no. 6 (June 2000): 911–16. http://dx.doi.org/10.1016/s0194-59980070024-6.

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Subglottic tracheal stenosis is a common clinical entity. Management in severe cases is often problematic. Various techniques for tracheal replacement have been used with varying degrees of success. In this study we used cryopreserved, irradiated tracheal homografts, the use of which in human beings has not been reported previously. In a sterile setup, the tracheas were harvested from donor cadavers within 24 hours of death. The grafts were initially kept at 57°C for 20 minutes; they were then placed in a −70°C chamber for another 2 to 3 days or more and were irradiated to 25 kGy (2.5 million rad). Finally, the grafts were stored at −70°C until usage. Seven patients underwent the surgery, but only 4 are presented here. In the remaining 3 patients, the follow-up time was too short to be evaluated. Four patients, 2 male and 2 female (aged 2-40 years, mean 16 years), with severe subglottic tracheal stenosis underwent segmental tracheal graft reconstruction. Immunosuppressant medications were not given to any patient. Follow-up ranged from 18 to 20 months. Three patients successfully underwent decannulation, and 1 patient had local infection and dislodgment of the intraluminal stent with subsequent restenosis. The postoperative tracheal lumen appeared to be near normal, with histologic evidence of normal respiratory epithelium at the grafted site. In conclusion, cryopreserved, irradiated tracheal homograft transplantation is a valuable alternative for subglottic tracheal reconstruction.
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Dimarakis, Ioannis, Wilfred Wooldridge, and Isaac Kadir. "Homograft Aortic Root Replacement with Saphenous Vein Graft Hemi-Cabrol for Prosthetic Aortic Valve Endocarditis." AORTA 03, no. 02 (April 2015): 81–85. http://dx.doi.org/10.12945/j.aorta.2015.14-047.

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AbstractA 44-year-old female presented with prosthetic valve endocarditis with periannular abscess involving the left coronary ostium. We describe cryopreserved aortic homograft root replacement with hemi-Cabrol reimplantation of the left coronary ostium using the long saphenous vein.
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25

ABAD, C., A. HURLE, J. FEIJOO, J. GOMEZMARRERO, and A. ABDALLAH. "Total aortic arch replacement by a cryopreserved aortic homograft." European Journal of Cardio-Thoracic Surgery 9, no. 9 (1995): 531–33. http://dx.doi.org/10.1016/s1010-7940(95)80056-5.

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26

Mascoli, Chiara, Marielda D''Ambra, Riccardo Casadei, Claudio Ricci, Giovanni Taffurelli, Stefano Ancetti, Andrea Stella, Francesco Minni, and Antonio Freyrie. "Portal/Superior Mesenteric Vein Reconstruction during Pancreatic Resection Using a Cryopreserved Arterial Homograft." Digestive Surgery 32, no. 4 (2015): 284–90. http://dx.doi.org/10.1159/000381194.

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Background: Portal-superior mesenteric vein (PV/SMV) resection during pancreatic resection has been widely applied in clinical practice. Methods: From a prospective data base of pancreatic resections, patients undergoing PV/SMV resection and reconstruction with a cryopreserved arterial homograft were extracted with the aim of evaluating the safety, feasibility and reproducibility of the procedure. Data regarding patient demographics, preoperative staging, surgery, histopathology and postoperative outcomes were analyzed. Results: Five patients were extracted in the last year. Indications for this technique were type IV-V degree of vein involvement and a 3.5 cm median length of vein infiltration. Median operative and clamping times were satisfactory (385 and 27 min, respectively), postoperative outcomes were good and there was no graft infection, thrombosis or stenosis occurred postoperatively and during the follow-up period. Conclusion: The use of a cryopreserved arterial homograft for PV/SMV reconstruction after pancreatic resection seems to be a feasible, safe and easily reproducible surgical technique in high-volume specialized centers and can be added to the pool of surgical solutions in selected patients.
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Meyns, Bart, Ramadan Jashari, Marc Gewillig, Luc Mertens, Arnošt Komárek, Emmanuel Lesaffre, Werner Budts, and Willem Daenen. "Factors influencing the survival of cryopreserved homografts. The second homograft performs as well as the first☆." European Journal of Cardio-Thoracic Surgery 28, no. 2 (August 2005): 211–16. http://dx.doi.org/10.1016/j.ejcts.2005.03.041.

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28

Gates, Jonathan D., James A. Warth, and Katherine McGowan. "Nocardia asteroides–Infected Aneurysm of the Aorta: Case Report and Review of the Literature." Vascular 14, no. 3 (May 1, 2006): 165–68. http://dx.doi.org/10.2310/6670.2006.00025.

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Infected aneurysms of the aorta were first described as a result of septic emboli or contiguous spread from bacterial endocarditis and are usually caused by Staphylococcus or Salmonella species. We report a case of Nocardia-associated infected aneurysm of the native suprarenal aorta in an immunocompromised host. Surgical management consisted of placement of an interposition cryopreserved aortic homograft. Nocardia asteroides was identified on a microbiology specimen of the aorta and both microbiology and pathology specimens of the splenic tissue. To the best of our knowledge, this represents the first carefully documented, unique case of a Nocardia-infected aneurysm treated with homograft interposition. In addition, pathologic and microbiologic data are included from the postmortem examination 10 months later.
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29

Koolbergen, David R., Mark G. Hazekamp, Emile de Heer, Eline F. Bruggemans, Hans A. Huysmans, Robert A. E. Dion, and Jan A. Bruijn. "The pathology of fresh and cryopreserved homograft heart valves: An analysis of forty explanted homograft valves." Journal of Thoracic and Cardiovascular Surgery 124, no. 4 (October 2002): 689–97. http://dx.doi.org/10.1067/mtc.2002.124514.

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Inoue, Yosuke, Ryoshi Maruyama, Yukio Hasegawa, Eiichiro Hata, Akira Yamada, Katsuhiko Nakanishi, and Keisuke Sakai. "A Case of Ruptured Cryopreserved Homograft 7 Months after Implantation." Japanese Journal of Cardiovascular Surgery 42, no. 2 (2013): 128–31. http://dx.doi.org/10.4326/jjcvs.42.128.

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31

CICHON, ROMUALD, SEETHAPATHY MURALIDHARAN, JIANG GU, JAVIER FERNANDEZ, CONNIE DALOISIO, MICHAEL D'ANDREA, ZBIGNIEW RELIGA, and LYNN B. McGRATH. "The Cryopreserved Stented Pulmonary Homograft Valve in the Tricuspid Position." Journal of Cardiac Surgery 6, no. 4 (December 1991): 468–75. http://dx.doi.org/10.1111/j.1540-8191.1991.tb00347.x.

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32

Quatromoni, Jon, Ann Gaffey, Robert Swendiman, Robert Roses, Major Lee, Paul Foley, Ronald Fairman, and Benjamin Jackson. "Portal Vein Reconstruction With Interposition Cryopreserved Descending Thoracic Aortic Homograft." Journal of Vascular Surgery 72, no. 5 (November 2020): e369-e370. http://dx.doi.org/10.1016/j.jvs.2020.08.093.

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33

Luk, Adriana, Jagdish Butany, Sarah A. Erlich, Jessica Henry, and Tirone E. David. "Long-term morphological changes in a cryopreserved pulmonary valve homograft." Canadian Journal of Cardiology 23, no. 10 (August 2007): 817–19. http://dx.doi.org/10.1016/s0828-282x(07)70834-6.

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34

Nappi, Francesco. "CRT-721 The Cryopreserved Mitral Homograft Valve: 19 Years Experience." JACC: Cardiovascular Interventions 7, no. 2 (February 2014): S58. http://dx.doi.org/10.1016/j.jcin.2014.01.140.

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35

Gonzalez-Lavin, Lorenzo, Lynn B. McGrath, Saeid Amini, and Debra Graf. "Determining viability of fresh or cryopreserved homograft valves at implantation." Heart and Vessels 3, no. 4 (December 1987): 205–8. http://dx.doi.org/10.1007/bf02058312.

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36

ZIEMER, G., I. LUHMER, F. SICLARI, and H. KALLFELZ. "Truncus arteriosus type A3: complex repair with cryopreserved pulmonary homograft." European Journal of Cardio-Thoracic Surgery 1, no. 2 (1987): 110–15. http://dx.doi.org/10.1016/1010-7940(87)90021-2.

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37

Iguchi, Atsushi, Makato Miura, and Koichi Tabayashi. "Cryopreserved Aortic Homograft Replacement in a Patient With Takayasu's Arteritis." Japanese Circulation Journal 63, no. 7 (1999): 569–71. http://dx.doi.org/10.1253/jcj.63.569.

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38

Mezzetto, Luca, Lorenzo Scorsone, Rosario Pacca, Giovanni Puppini, Simone Perandini, and Gian Franco Veraldi. "Treatment of Popliteal Artery Aneurysms by Means of Cryopreserved Homograft." Annals of Vascular Surgery 29, no. 6 (August 2015): 1090–96. http://dx.doi.org/10.1016/j.avsg.2015.02.007.

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39

Marathe, Supreet P., Douglas Bell, Kim Betts, Sajid Sayed, Benjamin Dunne, Cameron Ward, Chris Whight, et al. "Homografts versus stentless bioprosthetic valves in the pulmonary position: a multicentre propensity-matched comparison in patients younger than 20 years†." European Journal of Cardio-Thoracic Surgery 56, no. 2 (February 7, 2019): 377–84. http://dx.doi.org/10.1093/ejcts/ezz021.

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Abstract OBJECTIVES The aim of this study was to compare the performance of pulmonary homografts with stentless bioprosthetic valves [Medtronic Freestyle™ (Medtronic, Minneapolis, MN, USA)] in the pulmonary position in patients with congenital heart disease (CHD) younger than 20 years. METHODS Between January 2000 and December 2017, 215 patients were retrospectively identified from hospital databases in 3 congenital heart centres in Australia. Valve performance was evaluated using standard criteria. Propensity score matching was used to balance the 2 treatment groups. RESULTS Freedom from reintervention for patients who received a pulmonary homograft (n = 163) was 96%, 88% and 81% at 5, 10 and 15 years and for patients who received a Freestyle™ valve (n = 52) was 98%, 89% and 31% at 5, 10 and 15 years, respectively. Freedom from structural valve degeneration for patients with a homograft was 92%, 87% and 77% at 5, 10 and 15 years and for patients with a Freestyle valve was 96%, 80% and 14% at 5, 10 and 15 years, respectively. In the first 10 years, there was no difference in outcomes [reintervention hazard ratios (HR) = 0.69, 95% confidence intervals (CI) (0.20–2.42), P = 0.56; structural valve degeneration HR = 0.92 (0.34–2.51), P = 0.87]. After 10 years, the recipients of the Freestyle valves were at higher risk of both outcomes [reintervention HR = 7.89; 95% CI (2.79–22.34), P < 0.001; structural valve degeneration HR = 7.41 (2.77–19.84), P < 0.001]. The findings were similar when analysed by implantation in the orthotopic position and in the propensity-matched groups. CONCLUSIONS The Freestyle stentless bioprosthetic valve is a comparable alternative to cryopreserved pulmonary homografts up to 10 years after implantation when implanted in an orthotopic pulmonary position in patients younger than 20 years with CHD.
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40

Park, Samina, Ho Young Hwang, Kyung-Hwan Kim, Ki-Bong Kim, and Hyuk Ahn. "Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position." Korean Journal of Thoracic and Cardiovascular Surgery 45, no. 1 (February 29, 2012): 30–34. http://dx.doi.org/10.5090/kjtcs.2012.45.1.30.

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41

Eriksson, Maria J., Göran Källner, Stefan Rosfors, Torbjörn Ivert, and Lars-Åke Brodin. "Hemodynamic performance of cryopreserved aortic homograft valves during midterm follow-up." Journal of the American College of Cardiology 32, no. 4 (October 1998): 1002–8. http://dx.doi.org/10.1016/s0735-1097(98)00352-0.

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42

Zwischenberger, Joseph B., Tarek Zaghloul Shalaby, and Vincent R. Conti. "Viable Cryopreserved Aortic Homograft for Aortic Valve Endocarditis and Annular Abscesses." Annals of Thoracic Surgery 48, no. 3 (September 1989): 365–70. http://dx.doi.org/10.1016/s0003-4975(10)62858-5.

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43

KUNACHAK, S., B. KULAPADITHAROM, Y. VAJARADUL, and M. ROCHANAWUTANON. "Cryopreserved, irradiated tracheal homograft transplantation for laryngotracheal reconstruction in human beings☆." Otolaryngology - Head and Neck Surgery 122, no. 6 (June 2000): 911–16. http://dx.doi.org/10.1016/s0194-5998(00)70024-6.

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44

Byrne, John G., Alexandros N. Karavas, Tomislav Mihaljevic, James D. Rawn, Sary F. Aranki, and Lawrence H. Cohn. "Role of the cryopreserved homograft in isolated elective aortic valve replacement." American Journal of Cardiology 91, no. 5 (March 2003): 616–19. http://dx.doi.org/10.1016/s0002-9149(02)03323-4.

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45

Barili, Fabio, Luca Dainese, Faisal H. Cheema, Giacomo Dell'Antonio, Veli K. Topkara, Giuseppe Rossoni, Anna Guarino, et al. "Rates of Cycling Cells in Cryopreserved Valvular Homograft: A Preliminary Study." Artificial Organs 31, no. 2 (February 2007): 152–54. http://dx.doi.org/10.1111/j.1525-1594.2007.00355.x.

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46

Danilowicz, Delores, Salvatore Presti, Stephen B. Colvin, and Eugenie F. Doyle. "Repair in infancy of tetralogy of Fallot with absence of the leaflets of the pulmonary valve (absent pulmonary valve syndrome) using a valved pulmonary artery homograft." Cardiology in the Young 2, no. 1 (January 1992): 25–29. http://dx.doi.org/10.1017/s1047951100000548.

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SummaryTwo infants, aged eight days and four months, with tetralogy of Fallot and absence of the leaflets of the pulmonary valve, presented with acute respiratory distress and congestive heart failure. Primary repair was performed using a cryopreserved pulmonary arterial homograft. Both infants survived and are doing well three and two years later. A review of the surgical procedures attempted in this symptomatic group of patients is presented together with a discussion of the pathophysiology of this defect.
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Bors, Valeria, Pierre Sabouret, André Marquand, Alphonse Nzomvuama, Alain Pavie, and Iradj Gandjbakhch. "Tricuspid valve replacement with cryopreserved mitral homograft in patients with hemodynamic impairment." Journal of Cardiac Failure 4, no. 3 (September 1998): 30. http://dx.doi.org/10.1016/s1071-9164(98)90111-7.

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Vogt, Paul R., Michele Genoni, Andreas Künzli, and Marko I. Turina. "Cryopreserved homograft monocusp valves for reconstruction of the right ventricular outflow tract." Journal of Thoracic and Cardiovascular Surgery 113, no. 2 (February 1997): 423. http://dx.doi.org/10.1016/s0022-5223(97)70345-3.

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Sakuma, Kei, Hiroji Akimoto, Hitoshi Yokoyama, Atsushi Iguchi, and Koichi Tabayashi. "Cryopreserved aortic homograft replacement in 3 patients with noninfectious inflammatory vascular disease." Japanese Journal of Thoracic and Cardiovascular Surgery 49, no. 11 (November 2001): 652–55. http://dx.doi.org/10.1007/bf02912473.

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Riberi, A. "Aortic valve or root replacement with cryopreserved homograft for active infectious endocarditis." Cardiovascular Surgery 5, no. 6 (December 1997): 579–83. http://dx.doi.org/10.1016/s0967-2109(97)00074-4.

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