Relevant bibliographies by topics / Cre8

Academic literature on the topic 'Cre8'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Cre8"

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Cui, Jiangkuan, Huan Peng, Wenkun Huang, Shiming Liu, Duqing Wu, Lingan Kong, Wenting He, and Deliang Peng. "Phenotype and Cellular Response of Wheat Lines Carrying Cre Genes to Heterodera avenae Pathotype Ha91." Plant Disease 101, no. 11 (November 2017): 1885–94. http://dx.doi.org/10.1094/pdis-03-17-0404-re.

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The cereal cyst nematode (CCN, Heterodera avenae), a major limiting factor for wheat production worldwide, is widespread in most wheat-growing regions in China. Accordingly, screening and characterization of resistant (R) wheat sources against H. avenae are very important. In this study, we screened 51 wheat lines, collected from the International Wheat and Maize Improvement Center (CIMMYT), carrying various Cre genes (Cre1, Cre2, Cre3, Cre5, Cre7, Cre8, CreR, and Pt). From that screen, we identified one immune (M) cultivar (with no adult females produced) and five resistant cultivars (with fewer than five females) to H. avenae pathotype Ha91. The Cre3 gene conferred the most effective resistance against H. avenae pathotype Ha91 in both field and greenhouse assays. Conversely, the Cre1 and CreR genes conferred the poorest effective resistance. Using Pluronic F-127 gel and a staining assay, juvenile nematodes invading wheat roots were observed, and nematode development was analyzed. Compared with R and M roots, those of the susceptible (S) wheat cultivar Wenmai19 were more attractive to H. avenae second-stage juveniles (J2s). We observed the retardation of nematode development in R cultivars and tiny white female cysts protruding from the R cultivar VP1620. Nematodes in M roots either disintegrated or remained J2s or third-stage juveniles (J3s) and failed to complete their life cycle. Molting was also suppressed or delayed in R and M genotypes. For both S and R cultivars, syncytia were characterized by cell wall perforations and dense cytoplasm in hypertrophied syncytium component cells. Syncytial size increased gradually with nematode development in S cultivars. Moreover, an incompatibility reaction occurred in M wheat roots: the syncytium was disorganized, exhibiting disintegration and condensed nuclei. These sources of genetic resistance against CCN can potentially be planted in severely infested fields to reduce economic loss or can be used for introgression in breeding.
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Hay, Colin W., Elaine M. Sinclair, Giovanna Bermano, Elaine Durward, Mohammad Tadayyon, and Kevin Docherty. "Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site." Journal of Endocrinology 186, no. 2 (August 2005): 353–65. http://dx.doi.org/10.1677/joe.1.06205.

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Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted from the enteroendocrine L-cells of the gut and which acts primarily to potentiate the effects of glucose on insulin secretion from pancreatic β-cells. It also stimulates insulin gene expression, proinsulin biosynthesis and affects the growth and differentiation of the islets of Langerhans. Previous studies on the mechanisms whereby GLP-1 regulates insulin gene transcription have focused on the rat insulin promoter. The aim of this study was to determine whether the human insulin promoter was also responsive to GLP-1, and if so to investigate the possible role of cAMP-responsive elements (CREs) that lie upstream (CRE1 and CRE2) and downstream (CRE3 and CRE4) of the transcription start site. INS-1 pancreatic β-cells were transfected with promoter constructs containing fragments of the insulin gene promoter placed upstream of the firefly luciferase reporter gene. GLP-1 was found to stimulate the human insulin promoter, albeit to a lesser degree than the rat insulin promoter. Mutagenesis of CRE2, CRE3 and CRE4 blocked the stimulatory effect of GLP-1 while mutagenesis of CRE1 had no effect. Analysis of nuclear protein binding to the four CREs showed that, while they share some proteins, each CRE site is unique. Stimulation of transcription by GLP-1 through CRE2, CRE3 and CRE4 resulted in altered protein binding that was different for each of the CRE sites involved. Collectively, these data show that the four human CREs are not simply multiple copies of the rat CRE site and further emphasise that the human insulin promoter is distinct from the rodent promoter.
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Smiley, Richard W., Guiping Yan, and John N. Pinkerton. "Resistance of wheat, barley and oat to Heterodera avenae in the Pacific Northwest, USA." Nematology 13, no. 5 (2011): 539–52. http://dx.doi.org/10.1163/138855410x531862.

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Abstract The cereal cyst nematode, Heterodera avenae, occurs in at least seven western states of the USA and reduces grain yield in localised regions and in selected crop management systems. Virulence phenotypes for H. avenae populations in North America have not been reported. Nine individual assays in six experiments were conducted to determine the reactions of barley, oat and wheat cultivars to five H. avenae populations in the Pacific Northwest (PNW) states of Idaho, Oregon and Washington. Three populations were evaluated for virulence to 23 entries of the 'International Test Assortment for Defining Cereal Cyst Nematode Pathotypes', plus selected local cultivars and entries representing a greater diversity of resistance genes. The virulence phenotype(s) for populations of H. avenae in the PNW did not correspond to any of the 11 pathotypes defined by the Test Assortment. Five PNW populations exhibited affinities with Group 2 but were not defined by pathotypes Ha12 and Ha22. Reproduction was prevented or greatly inhibited by barley carrying the Rha3 resistance gene and by most carriers of Rha2 resistance, and by selected oat cultivars with multigenic resistance. Wheat cultivars carrying the Cre1 resistance gene were highly effective in suppressing H. avenae reproduction. Current PNW wheat cultivars do not carry the Cre1 resistance gene. Crosses between Ouyen, an Australian bread wheat with Cre1 resistance, and several PNW wheat cultivars were resistant. The CreR gene also prevented H. avenae reproduction in the trial where it was tested. Intermediate levels of reproduction occurred on wheat cultivars carrying the Cre5, Cre7 and Cre8 resistance genes, each of which was considered useful for pyramiding into cultivars with Cre1 resistance. This research identified genetic resources of value in PNW cereal crop breeding programmes.
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Safari, E., N. N. Gororo, R. F. Eastwood, J. Lewis, H. A. Eagles, and F. C. Ogbonnaya. "Impact of Cre1, Cre8 and Cre3 genes on cereal cyst nematode resistance in wheat." Theoretical and Applied Genetics 110, no. 3 (January 18, 2005): 567–72. http://dx.doi.org/10.1007/s00122-004-1873-8.

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Mountfort, Katrina, Didier Carrié, Marco Valgimigli, Gennaro Sardella, Shmuel Banai, Rafael Romaguera, and Pieter Stella. "Meeting the Unmet – The Cre8 Polymer-free Drug-eluting Stents Technology." Interventional Cardiology Review 9, no. 3 (2014): 184. http://dx.doi.org/10.15420/icr.2014.9.3.184.

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The use of first-generation drug-eluting stents (DES) has been associated with safety concerns such as very late stent thrombosis. Today, with the release of newer DES, there is a need for comparative studies of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) to demonstrate their value in patients with high risk of restenosis such as diabetic patients. In a satellite symposium presented at EuroPCR 2014, the Cre8™ DES was discussed. The Cre8 device has a number of unique clinical features, including polymer-free technology, abluminal reservoir technology and bio-inducer surface that ensure effective neointima suppression and rapid endothelialisation. The efficacy of the Cre8 DES has been demonstrated in the International randomised comparison between DES Limus Carbostent and Taxus drug-eluting stents in the treatment of de novo coronary lesions (NEXT) randomised clinical study, with equivalent efficacy in the diabetic and general populations, a unique finding. Ongoing clinical studies such as Investig8 and the Tel Aviv Medical Center (TLVMC) Cre8 study have confirmed the efficacy of the device in patient populations with a high proportion of diabetic patients. The Demonstr8 randomised trial has shown almost complete Cre8 strut coverage at three months with a numerical advantage versus bare metal stent (bare metal stents [BMS] – comparator device) at one month. In addition, use of the Cre8 DES may enable a shorter duration of dual antiplatelet therapy (DAPT) following PCI. The Cre8 DES therefore represents a significant advance in stent technology and may be particularly useful in challenging clinical settings
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Romaguera, Rafael, Pablo Salinas, Josep Gomez-Lara, Salvatore Brugaletta, Antonio Gómez-Menchero, Miguel A. Romero, Sergio García-Blas, et al. "Amphilimus- vs. zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: the SUGAR trial." European Heart Journal 43, no. 13 (December 10, 2021): 1320–30. http://dx.doi.org/10.1093/eurheartj/ehab790.

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Abstract Aim Patients with diabetes mellitus are at high risk of adverse events after percutaneous revascularization, with no differences in outcomes between most contemporary drug-eluting stents. The Cre8 EVO stent releases a formulation of sirolimus with an amphiphilic carrier from laser-dug wells, and has shown clinical benefits in diabetes. We aimed to compare Cre8 EVO stents to Resolute Onyx stents (a contemporary polymer-based zotarolimus-eluting stent) in patients with diabetes. Methods and results We did an investigator-initiated, randomized, controlled, assessor-blinded trial at 23 sites in Spain. Eligible patients had diabetes and required percutaneous coronary intervention. A total of 1175 patients were randomly assigned (1:1) to receive Cre8 EVO or Resolute Onyx stents. The primary endpoint was target-lesion failure, defined as a composite of cardiac death, target-vessel myocardial infarction, and clinically indicated target-lesion revascularization at 1-year follow-up. The trial had a non-inferiority design with a 4% margin for the primary endpoint. A superiority analysis was planned if non-inferiority was confirmed. There were 106 primary events, 42 (7.2%) in the Cre8 EVO group and 64 (10.9%) in the Resolute Onyx group [hazard ratio (HR): 0.65, 95% confidence interval (CI): 0.44–0.96; Pnon-inferiority < 0.001; Psuperiority = 0.030]. Among the secondary endpoints, Cre8 EVO stents had significantly lower rate than Resolute Onyx stents of target-vessel failure (7.5% vs. 11.1%, HR: 0.67, 95% CI: 0.46–0.99; P = 0.042). Probable or definite stent thrombosis and all-cause death were not significantly different between groups. Conclusion In patients with diabetes, Cre8 EVO stents were non-inferior to Resolute Onyx stents with regard to target-lesion failure composite outcome. An exploratory analysis for superiority at 1 year suggests that the Cre8 EVO stents might be superior to Resolute Onyx stents with regard to the same outcome. Clinical trial registration ClinicalTrials.gov: NCT03321032.
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Carrié, Didier. "The Use of the Cre8 Stent in Patients with Diabetes Mellitus." Interventional Cardiology Review 11, no. 1 (2016): 47. http://dx.doi.org/10.15420/icr.2016.11.01.47.

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Despite improved clinical outcomes following the availability of second-generation drug eluting stents (DES), percutaneous coronary intervention (PCI) is associated with worse clinical and angiographic outcomes among patients with diabetes mellitus (DM) than among non-diabetics. The Cre8™ Amphilimus-eluting DES is polymer-free, resulting in a reduced inflammatory response and lower risk of stent thrombosis. It showed equivalent efficacy and safety in diabetic and non-diabetic populations, a unique finding among DES studies. These findings were confirmed in a real-world study called INVESTIG8. Another real-world study, pARTicip8, is ongoing. The RESERVOIR clinical trial recruited patients with diabetes mellitus and showed noninferiority of the Cre8 DES compared to an everolimus-eluting DES but showed a statistical superiority of Cre8 in diabetic patients with higher metabolic dysfunctions. The Cre8 DES is therefore a valuable option for this important patient population.
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Carrié, Didier. "The Use of the Cre8 Stent in Patients with Diabetes Mellitus." Interventional Cardiology Review 11, no. 1 (2016): 47. http://dx.doi.org/10.15420/icr.2016.11.1.47.

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Despite improved clinical outcomes following the availability of second-generation drug eluting stents (DES), percutaneous coronary intervention (PCI) is associated with worse clinical and angiographic outcomes among patients with diabetes mellitus (DM) than among non-diabetics. The Cre8™ Amphilimus-eluting DES is polymer-free, resulting in a reduced inflammatory response and lower risk of stent thrombosis. It showed equivalent efficacy and safety in diabetic and non-diabetic populations, a unique finding among DES studies. These findings were confirmed in a real-world study called INVESTIG8. Another real-world study, pARTicip8, is ongoing. The RESERVOIR clinical trial recruited patients with diabetes mellitus and showed noninferiority of the Cre8 DES compared to an everolimus-eluting DES but showed a statistical superiority of Cre8 in diabetic patients with higher metabolic dysfunctions. The Cre8 DES is therefore a valuable option for this important patient population.
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Moatamedi, Marzieh, Eidi Bazgir, Mehdi Nasr Esfahani, and Mostafa Darvishnia. "Genetic variation of bread wheat accessions in response to the cereal cyst nematode, Heterodera filipjevi." Nematology 20, no. 9 (2018): 859–75. http://dx.doi.org/10.1163/15685411-00003181.

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Summary Bread wheat, Triticum aestivum, produces large edible grains and is consumed by 75% of the world’s populations. Cereal cyst nematodes have a global distribution and cause significant economic yield losses in many countries. Therefore, there is an urgent need to identify new resistance sources. In this study, the genetic diversity of 43 wheat accessions in response to cereal cyst nematode, Heterodera filipjevi Isfahan pathotype, was assessed using a simple sequence repeat (SSR) marker. Seven primers were used, out of which five primers showed polymorphisms. Alleles per primer varied from one to three per locus (mean 2.85). The highest and lowest polymorphic information content of 0.81 and 0.44 (mean 0.66) were related to Xgwm 3012DL and Xgwm147, respectively. Genetic similarity was 29-88% between accessions. SSR analysis divided the accessions into five main groups. Resistant cultivars ‘Bam’ and ‘Behrang’ possessed both Cre1 and Cre8 resistant genes. The Cre3 and Cat genes were partially sequenced in five cultivars of different responses to H. filipjevi. The nucleotide sequences were compared to Cre3 and Cat homologues, indicating 93-100% and 86-92% homology, respectively. The MEGA program showed highest similarity of Cre3 and Cat genes amplified with the resistance gene analogues (RGA14) in the wheat and Cat3-A1 gene in ‘Carnamah’. This research showed that SRR markers could efficiently verify genetic diversity between wheat accessions, and the known resistance genes (Cre genes) against the cereal cyst nematodes could not control the H. filipjevi Isfahan pathotype populations, except the Cre1 gene.
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Manna, PR, DW Eubank, E. Lalli, P. Sassone-Corsi, and DM Stocco. "Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1." Journal of Molecular Endocrinology 30, no. 3 (June 1, 2003): 381–97. http://dx.doi.org/10.1677/jme.0.0300381.

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Transcriptional induction by cAMP is mediated through the interaction of the cAMP response-element binding protein (CREB) with a cAMP response element (CRE) in the promoter of target genes. The steroidogenic acute regulatory (StAR) protein gene is regulated by cAMP-mediated signaling in steroidogenic cells even though its promoter lacks a consensus CRE. Previously, we have identified three highly conserved 5'-CRE half-sites within the -96/-67 bp region of the mouse StAR gene, and a member of the CREB family (CREB/CRE modulator (CREM)) was shown to be involved in its expression and regulation. Here we show that CREB and CREMtau (but not CREMalpha and CREMbeta) have qualitatively similar effects on StAR promoter activity in response to (Bu)(2)cAMP. Studies on the effects of the functional integrity of the CRE half-sites on CREB-dependent (Bu)(2)cAMP-mediated StAR gene transcription demonstrated the greater importance of the CRE2 site in comparison with the CRE1 and CRE3 sites. The CRE2 sequence was also found to bind specifically to recombinant CREB protein and nuclear extract from MA-10 mouse Leydig tumor cells. The cAMP and CREB/CREM responsive region (-151/-1 bp) of the mouse StAR promoter also contains three recognition motifs for steroidogenic factor 1 (SF-1). Electrophoretic mobility shift assays and reporter gene analyses demonstrated the involvement of different SF-1 elements in StAR gene expression with the order of importance being SF-1/3>SF-1/1>SF-1/2. Specific mutations that eliminated the binding sites of CRE and SF-1 elements, either alone or in combination, resulted in an attenuation of StAR promoter activity, indicating that CREB and SF-1 can regulate StAR gene transcription in a cooperative fashion. In addition, mammalian two-hybrid assays revealed a high affinity protein-protein interaction between CREB/CREMtau and SF-1 which appeared to be dependent upon CREB protein phosphorylation. These findings further demonstrate CREB's role in StAR gene transcription and also provide evidence that the combined action of CREB/CREMtau and SF-1 results in enhanced activation of the StAR promoter.
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Dissertations / Theses on the topic "Cre8"

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Glas, Evi Verfasser], and Harald [Akademischer Betreuer] [Mückter. "CREB-Phosphorylierung und CRE-Aktivierung in murinen Hypothalamuszellen / Evi Glas ; Betreuer: Harald Mückter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1127527843/34.

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Smith, David M. "A role for adenylyl cyclase and the CREB/CRE transctiptional pathway in mammalian behavior /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6296.

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Steingräber, Annika Kathrin [Verfasser], and Frank Ulrich [Akademischer Betreuer] Müller. "Bedeutung der Transkriptionsfaktoren CREB und CREM für die vaskuläre Funktion / Annika Kathrin Steingräber. Betreuer: Frank Ulrich Müller." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1017934436/34.

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Uyttersprot, Nathalie. "Rôle des facteurs de transcription CREB et CREM dans la voie mitogénique dépendante de l'AMPc dans les cellules thyroïdiennes de chien." Doctoral thesis, Universite Libre de Bruxelles, 1998. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212027.

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Simmler, Urs. "Simulation-News in Creo 1.0 & Creo 2.0." Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-87115.

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Simulation-News in Creo 1.0 & Creo 2.0 - Mechanica (neu: Simulate) Druckbehälter: Schraubenvorspannung / Betriebslast - Live-Präsentation in Creo 2.0 Berechnung eine Druckbehälters unter Berücksichtigung von: Schraubenvorspannung, Betriebslast, zeitabhängiger Lastaufbringung
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Wastesicoot, Jennie. "Tapwetamowin: Cree Spirituality and Law for Self-Governance." JCharlton Publishing Ltd, 2014. http://hdl.handle.net/1993/30319.

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This doctoral thesis explores the uniqueness of Cree spirituality and law, based in part on oral histories and on Euro-Canadian literal evidence, specifically the multi-volumes of the Jesuit Relations and the thousands of Hudson’s Bay Company manuscripts that re-enforce insights into this Aboriginal governing system. Taken together, the oral and literal primary evidences will define how spirituality and law pre-existed colonisation and are manifested within self-governing institutions currently pursued by First Nations. The purpose is to understand better Cree spirituality and law as captured in Cree self-government models. This Aboriginal legal history contains and studies a plan of action for future self-governance based on inherent Aboriginal legal traditions and jurisprudence.
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Lauffer, Lisa [Verfasser], and Thomas [Akademischer Betreuer] Gudermann. "Der Einfluss von 5-Hydroxytryptamin und Glucose auf die CREB/CRE-vermittelte Genexpression in murinen Hypothalamuszellen / Lisa Lauffer ; Betreuer: Thomas Gudermann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1211957667/34.

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Nguyen, Thi Lien-Anh. "Etude du rôle de l'acétylation protéique et des éléments de réponse à l'AMP cyclique dans la régulation transcriptionnelle du virus de la leucémie bovine." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211118.

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Le virus de la leucémie bovine (BLV) est un rétrovirus B-lymphotrope qui a été identifié comme l’agent étiologique de la leucose bovine enzootique. L’infection par le BLV se caractérise par l’absence de virémie due à la latence du virus dans la majorité des cellules infectées. Cette latence résulte de la répression transcriptionnelle du provirus in vivo; elle favorise très probablement le développement tumoral en permettant aux cellules infectées d’échapper au système immunitaire de l’hôte. Cependant, la transcription du BLV peut être activée de manière rapide et très efficace par la protéine virale TaxBLV. La trans-activation par TaxBLV joue un rôle crucial dans la pathogenèse associée au BLV car elle permet la production de nouvelles particules virales nécessaires à la propagation du virus. Au cours de notre travail de thèse, nous avons étudié différents mécanismes impliqués au cours de ces deux phases clés (latence et trans-activation par TaxBLV) de l’expression du BLV.

Le promoteur unique de la transcription du BLV se situe à l’extrémité 5’ du génome proviral, dans la longue répétition terminale 5’ (LTR 5’) composée des régions U3, R et U5. Les mécanismes impliqués dans la trans-activation du LTR 5’ par TaxBLV sont encore mal connus. La trans-activation du LTR 5’ du BLV par TaxBLV requiert la présence de trois répétitions imparfaites de 21pb (TxREs pour Tax Responsive Elements) agissant en cis et situées dans la région U3. Chacune des TxREs possède dans sa partie centrale un motif imparfait de 8 nucléotides correspondant au site de liaison des protéines de la famille CREB/ATF (sites CREs pour cAMP-Responsive Element). Des expériences de retard de migration sur gel ont montré que les protéines CREB, ATF-1 et ATF-2 lient les CREs viraux in vitro. Comme TaxBLV ne semble pas capable de lier directement l’ADN du LTR, il a été suggéré que les facteurs CREB/ATF serviraient de médiateurs de la trans-activation par TaxBLV. De plus, il a également été suggéré au cours de ces dernières années que les facteurs de transcription CREB/ATF jouent aussi un rôle essentiel en l’absence de TaxBLV lors de l’initiation de la transcription virale.

CREB/ATF sont connus pour recruter les co-activateurs CBP/p300 qui possèdent une activité histone-acétyltransférase, suggérant qu’à l’instar d’autres rétrovirus tels que HIV-I ou HTLV-I, l’acétylation protéique pourrait jouer un rôle important dans la régulation de la transcription du BLV. Au cours de la première partie de ce travail, nous avons mis en évidence un synergisme transcriptionnel entre TaxBLV et les inhibiteurs de désacétylases TSA et NaBut, indiquant que l’acétylation protéique joue un rôle important dans la trans-activation par TaxBLV. Nous avons ensuite montré que ni TaxBLV, ni son médiateur CREB ne sont acétylés in vivo au niveau d’un résidu lysine interne, mais que la TSA synergise avec TaxBLV via un mécanisme indirect, sensible à l’inhibition de la synthèse protéique. Fonctionnellement, CREB/ATF semblent jouer un rôle crucial dans le synergisme TaxBLV/TSA car la mutation des CREs viraux ou la sur-expression d’un dominant négatif CREB inhibent ce synergisme. Des expériences de gel retard et de ChIP ont démontré, in vitro et in vivo, que les inhibiteurs de désacétylases augmentent la liaison des facteurs CREB/ATF aux TxREs. Nos résultats suggèrent donc que le synergisme TaxBLV/TSA serait dû à une augmentation de la trans-activation par TaxBLV observée suite à l’augmentation, induite par la TSA, du recrutement de CREB/ATF au niveau des TxREs.

CREB/ATF appartiennent à la famille des facteurs de transcription CREB/CREM/ATF agissant au niveau des promoteurs contenant des éléments CREs. Cependant, la liaison de CREM aux CREs imparfaits du LTR du BLV n’a jamais été étudiée. Dans la seconde partie de ce travail, nous avons montré que des isoformes du gène CREM sont exprimées dans des PBMCs isolés à partir d’un mouton infecté par le BLV et que ces protéines CREM sont capables de lier in vitro et in vivo le promoteur du BLV, via les motifs CREs présents au centre de chacune des TxREs. Des analyses fonctionnelles ont ensuite montré qu’en l’absence de TaxBLV, la surexpression de l’isoforme activatrice CREMt induit la transcription dirigée par le LTR 5’ du BLV. Les résultats que nous avons obtenus suggèrent que CREMt serait capable d’activer la transcription du BLV en réponse à l’activation des cellules B infectées, via la phosphorylation de la sérine 117 de CREMt et via le recrutement par CREMt des co-activateurs CBP/p300. CREMt serait donc impliqué dans les stades précoces de l’initiation de la transcription du BLV. Cependant, nous avons montré que CREMt n’est pas impliqué dans les stades tardifs de l’expression virale puisqu’il ne semble pas capable d’induire la trans-activation par TaxBLV. Au contraire, nous avons montré par des expériences de compétition que CREMt diminue la trans-activation par TaxBLV lorsque celle-ci est induite par CREB, probablement en entrant en compétition avec CREB pour la liaison au niveau des TxREs.

L’expression du gène CREM est régulée transcriptionnellement et post-transcriptionnellement et mène à la production de différentes isoformes capables d’agir comme des activateurs ou des répresseurs de la transcription. Des expériences de RT-PCR nous ont permis de mettre en évidence la présence d’isoformes répressives ICER dans les cellules YR2 infectées par le BLV. Par des expériences de transfection transitoire, nous avons montré qu’ICER est capable de réprimer la trans-activation par TaxBLV, suggérant qu’ICER retarderait la trans-activation par TaxBLV afin d’échapper au système immunitaire de l’hôte infecté jusqu’à ce qu’un niveau suffisant du trans-activateur TaxBLV soit produit.


Doctorat en sciences, Spécialisation chimie
info:eu-repo/semantics/nonPublished

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Nissen, Rüdiger. "Airline crew rescheduling /." Aachen : Shaker, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015625305&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Coronado, Jose. "Creo Simulate Roadmap." Technische Universität Chemnitz, 2018. https://monarch.qucosa.de/id/qucosa%3A21395.

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Books on the topic "Cre8"

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Crew. St. Leonards, NSW, Australia: Allen & Unwin, 1995.

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illustrator, Jablonski-Jones Martha, ed. Cree. Calgary, Alberta: Weigl, 2014.

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Cree. New York: PowerKids Press, 2016.

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Vogel, Manfred, and Thomas Ebel. Creo Parametric und Creo Simulate. München: Carl Hanser Verlag GmbH & Co. KG, 2012. http://dx.doi.org/10.3139/9783446431454.

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Philip, Ouvry, ed. Competent crew: For new crew and competent crew students. 5th ed. London: Adlard Coles Nautical, 2007.

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Cree language structures: A Cree approach. Winnipeg, Man., Canada: Pemmican Publications, 1987.

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Ceiliúradh cré. Baile Átha Cliath: Coisceim, 1992.

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King, Stephen. Skeleton crew. New York: G.P. Putnam's Sons, 1985.

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King, Stephen. Skeleton Crew. New York, USA: New American Library, 1986.

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Mellor, John. Young crew. Shrewsbury: Waterline Books, 1993.

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Book chapters on the topic "Cre8"

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Muysken, Pieter, and Geneviève Escure. "Creole linguistics." In Handbook of Pragmatics, 408–25. Amsterdam: John Benjamins Publishing Company, 2022. http://dx.doi.org/10.1075/hop.m2.cre1.

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Mufwene, Salikoko S. "Creoles and creolization." In Handbook of Pragmatics, 1–14. Amsterdam: John Benjamins Publishing Company, 1996. http://dx.doi.org/10.1075/hop.1.cre2.

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Muysken, Pieter, and Geneviève Escure. "Creole linguistics." In Handbook of Pragmatics, 1–24. Amsterdam: John Benjamins Publishing Company, 2006. http://dx.doi.org/10.1075/hop.10.cre1.

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Mufwene, Salikoko S. "Creoles and creolization." In Handbook of Pragmatics, 1–17. Amsterdam: John Benjamins Publishing Company, 2007. http://dx.doi.org/10.1075/hop.11.cre2.

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Pitzl, Marie-Luise. "Creativity in language use." In Handbook of Pragmatics, 1–28. Amsterdam: John Benjamins Publishing Company, 2013. http://dx.doi.org/10.1075/hop.17.cre3.

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O'Sullivan, Carol. "Creativity." In Handbook of Translation Studies, 42–46. Amsterdam: John Benjamins Publishing Company, 2013. http://dx.doi.org/10.1075/hts.4.cre1.

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Lee, Janet S., Monica Lamas, Katherine Tamai, Emmanuel Zazopoulos, Lucia Penna, Nicholas S. Foulkes, François Nantel, Enzo Lalli, and Paolo Sassone-Corsi. "CREM." In Cancer Genes, 143–60. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-5895-8_8.

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Yagishita-Kyo, Nan, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, and Haruhiko Bito. "CREB." In Encyclopedia of Signaling Molecules, 1203–9. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_180.

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Yagishita-Kyo, Nan, Masatoshi Inoue, Mio Nonaka, Hiroyuki Okuno, and Haruhiko Bito. "CREB." In Encyclopedia of Signaling Molecules, 1–7. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_180-1.

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Adelson, Naomi. "Cree." In Encyclopedia of Medical Anthropology, 614–22. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/0-387-29905-x_62.

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Conference papers on the topic "Cre8"

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Liu, Chen, Beng Chin Ooi, Anthony K. H. Tung, and Dongxiang Zhang. "Crew." In the international conference. New York, New York, USA: ACM Press, 2010. http://dx.doi.org/10.1145/1873951.1874318.

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Ji, Kaixiang, Jiajia Liu, Weixiang Hong, Liheng Zhong, Jian Wang, Jingdong Chen, and Wei Chu. "CRET." In SIGIR '22: The 45th International ACM SIGIR Conference on Research and Development in Information Retrieval. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3477495.3531960.

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Dorn, Márcio, and Osmar Norberto de Souza. "CReF." In the 2008 ACM symposium. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1363686.1363979.

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Jablonski, Patricia, and Daqing Hou. "CReN." In the 2007 OOPSLA workshop. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1328279.1328283.

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Wong, Stephanie, Samarth Singhal, and Carman Neustaedter. "Smart Crew." In CSCW '17: Computer Supported Cooperative Work and Social Computing. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3022198.3023274.

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Wong, Stephanie, Samarth Singhal, Carman Neustaedter, and Aynur Kadir. "Smart Crew." In CHI '17: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3027063.3049780.

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Volny, Delphine. "The crew." In ACM SIGGRAPH 2014 Computer Animation Festival. New York, New York, USA: ACM Press, 2014. http://dx.doi.org/10.1145/2633956.2633998.

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Harris, Gary L., and Pablo de León. "Crew Protection, Contingency EVA and the Crew Exploration Vehicle." In International Conference On Environmental Systems. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2006. http://dx.doi.org/10.4271/2006-01-2137.

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"CRET workshop organization." In 2017 International Conference on Platform Technology and Service (PlatCon). IEEE, 2017. http://dx.doi.org/10.1109/platcon.2017.7883666.

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Brice, Travis. "International crew operations." In Space Programs and Technologies Conference and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1993. http://dx.doi.org/10.2514/6.1993-4096.

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Reports on the topic "Cre8"

1

Rousculp, Christopher L., David Michael Oro, Jeffrey Randall Griego, Joseph Thomas Bradley, Brian J. Hollander, and Robert Emil Reinovsky. Cren(ulation)-­1,2 Preshot Report. Office of Scientific and Technical Information (OSTI), December 2015. http://dx.doi.org/10.2172/1233254.

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Zieleck, Kenneth. USMC KC-130J Crew Composition. Fort Belvoir, VA: Defense Technical Information Center, April 2002. http://dx.doi.org/10.21236/ada407158.

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Dungrani, Sanjiv, Melissa Fearnside, and Andrew Orlando. Crew Integration and Automation Technologies. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada454980.

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Stenger, Gregory J. Birdstrike Resistant Crew Enclosure Program. Fort Belvoir, VA: Defense Technical Information Center, August 1993. http://dx.doi.org/10.21236/ada273700.

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Sakamoto, Kathleen M. Role of CREB in CML. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada465180.

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Quintana, Adrian. Designing Fixtures and Learning Creo. Office of Scientific and Technical Information (OSTI), August 2022. http://dx.doi.org/10.2172/1881797.

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Holland, Darren, and Nazmina Mahmoudzadeh. Foodborne Disease Estimates for the United Kingdom in 2018. Food Standards Agency, January 2020. http://dx.doi.org/10.46756/sci.fsa.squ824.

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In February 2020 the FSA published two reports which produced new estimates of foodborne norovirus cases. These were the ‘Norovirus Attribution Study’ (NoVAS study) (O’Brien et al., 2020) and the accompanying internal FSA technical review ‘Technical Report: Review of Quantitative Risk Assessment of foodborne norovirus transmission’ (NoVAS model review), (Food Standards Agency, 2020). The NoVAS study produced a Quantitative Microbiological Risk Assessment model (QMRA) to estimate foodborne norovirus. The NoVAS model review considered the impact of using alternative assumptions and other data sources on these estimates. From these two pieces of work, a revised estimate of foodborne norovirus was produced. The FSA has therefore updated its estimates of annual foodborne disease to include these new results and also to take account of more recent data related to other pathogens. The estimates produced include: •Estimates of GP presentations and hospital admissions for foodbornenorovirus based on the new estimates of cases. The NoVAS study onlyproduced estimates for cases. •Estimates of foodborne cases, GP presentations and hospital admissions for12 other pathogens •Estimates of unattributed cases of foodborne disease •Estimates of total foodborne disease from all pathogens Previous estimates An FSA funded research project ‘The second study of infectious intestinal disease in the community’, published in 2012 and referred to as the IID2 study (Tam et al., 2012), estimated that there were 17 million cases of infectious intestinal disease (IID) in 2009. These include illness caused by all sources, not just food. Of these 17 million cases, around 40% (around 7 million) could be attributed to 13 known pathogens. These pathogens included norovirus. The remaining 60% of cases (equivalent to 10 million cases) were unattributed cases. These are cases where the causal pathogen is unknown. Reasons for this include the causal pathogen was not tested for, the test was not sensitive enough to detect the causal pathogen or the pathogen is unknown to science. A second project ‘Costed extension to the second study of infectious intestinal disease in the community’, published in 2014 and known as IID2 extension (Tam, Larose and O’Brien, 2014), estimated that there were 566,000 cases of foodborne disease per year caused by the same 13 known pathogens. Although a proportion of the unattributed cases would also be due to food, no estimate was provided for this in the IID2 extension. New estimates We estimate that there were 2.4 million cases of foodborne disease in the UK in 2018 (95% credible intervals 1.8 million to 3.1 million), with 222,000 GP presentations (95% Cred. Int. 150,000 to 322,000) and 16,400 hospital admissions (95% Cred. Int. 11,200 to 26,000). Of the estimated 2.4 million cases, 0.9 million (95% Cred. Int. 0.7 million to 1.2 million) were from the 13 known pathogens included in the IID2 extension and 1.4 million1 (95% Cred. Int. 1.0 million to 2.0 million) for unattributed cases. Norovirus was the pathogen with the largest estimate with 383,000 cases a year. However, this estimate is within the 95% credible interval for Campylobacter of 127,000 to 571,000. The pathogen with the next highest number of cases was Clostridium perfringens with 85,000 (95% Cred. Int. 32,000 to 225,000). While the methodology used in the NoVAS study does not lend itself to producing credible intervals for cases of norovirus, this does not mean that there is no uncertainty in these estimates. There were a number of parameters used in the NoVAS study which, while based on the best science currently available, were acknowledged to have uncertain values. Sensitivity analysis undertaken as part of the study showed that changes to the values of these parameters could make big differences to the overall estimates. Campylobacter was estimated to have the most GP presentations with 43,000 (95% Cred. Int. 19,000 to 76,000) followed by norovirus with 17,000 (95% Cred. Int. 11,000 to 26,000) and Clostridium perfringens with 13,000 (95% Cred. Int. 6,000 to 29,000). For hospital admissions Campylobacter was estimated to have 3,500 (95% Cred. Int. 1,400 to 7,600), followed by norovirus 2,200 (95% Cred. Int. 1,500 to 3,100) and Salmonella with 2,100 admissions (95% Cred. Int. 400 to 9,900). As many of these credible intervals overlap, any ranking needs to be undertaken with caution. While the estimates provided in this report are for 2018 the methodology described can be applied to future years.
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Sakamoto, Kathleen M. The Role of CREB in CML. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada493684.

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Kurnik, C., and C. Woodley. NREL Job Task Analysis: Crew Leader. Office of Scientific and Technical Information (OSTI), May 2011. http://dx.doi.org/10.2172/1016436.

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Standing Rock, Trevor. Chippewa Cree Residential Solar Deployment Project. Office of Scientific and Technical Information (OSTI), October 2018. http://dx.doi.org/10.2172/1503727.

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