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Journal articles on the topic 'CR4056'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Mota, Bibiana C., Nathan Ashburner, Laura Abelleira-Hervas, Liyueyue Liu, Robertas Aleksynas, Lucio Claudio Rovati, Gianfranco Caselli, and Magdalena Sastre. "I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice." International Journal of Molecular Sciences 23, no. 13 (June 30, 2022): 7320. http://dx.doi.org/10.3390/ijms23137320.

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Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in animal models of neurodegeneration, such as Alzheimer’s disease (AD). We recently demonstrated that the I2-ligand BU224 reversed memory impairments in AD transgenic mice and this effect was not because of reductions in amyloid-β (Aβ) deposition. In this study, our aim was to determine the therapeutic potential of the powerful analgesic I2-imidazoline ligand CR4056 in the 5xFAD model of AD, since this ligand has been proven to be safely tolerated in humans. Sub-chronic oral administration of CR4056 (30 mg/kg for 10 days) led to an improvement in recognition memory in 6-NOur results also revealed a change in the profile of microglia by CR4056, resulting in a suppression of pro-inflammatory activated microglia, but increased the density of astrocytes and the expression of ApoE, which is mainly produced by these glial cells. In addition, CR4056 restored fibrinogen extravasation, affecting the distribution of markers of astrocytic end feet in blood vessels. Therefore, these results suggest that CR4056 protects against Aβ-mediated neuroinflammation and vascular damage, and offers therapeutic potential at any stage of AD.

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2

Meregalli, C., A. Chiorazzi, A. Canta, V. Carozzi, N. Oggioni, F. Ferrarri, M. Lanza, et al. "186 CR4056: A NOVEL POTENT ANTI-NOCICEPTIVE AGENT FOR SEVERAL ANIMAL MODELS OF NEUROPATHIC PAIN." European Journal of Pain Supplements 4, S1 (April 2010): 55. http://dx.doi.org/10.1016/s1754-3207(10)70191-7.

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3

Comi, E., F. Ferrari, D. Tremolada, M. Lanza, G. Caselli, and L. C. Rovati. "CR4056, A selective imidazoline-2 ligand, improves osteoarthritis (OA) pain in the rat medial meniscal tear model." Osteoarthritis and Cartilage 24 (April 2016): S454. http://dx.doi.org/10.1016/j.joca.2016.01.827.

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4

Caselli, G., E. Comi, F. Ferrari, V. Mauri, L. Catapano, M. Lanza, M. Lanza, and L. C. Rovati. "Analgesic efficacy of cr4056, a novel i2-imidazoline receptor ligand, in the rat monosodium iodoacetate model of osteoarthritic pain." Osteoarthritis and Cartilage 23 (April 2015): A358. http://dx.doi.org/10.1016/j.joca.2015.02.660.

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5

Vellani, Vittorio, Chiara Sabatini, Chiara Milia, Gianfranco Caselli, Marco Lanza, Ornella Letari, Lucio Claudio Rovati, and Chiara Giacomoni. "CR4056, a powerful analgesic imidazoline‐2 receptor ligand, inhibits the inflammation‐induced PKCε phosphorylation and membrane translocation in sensory neurons." British Journal of Pharmacology 177, no. 1 (November 7, 2019): 48–64. http://dx.doi.org/10.1111/bph.14845.

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Menghetti, I., F. Ferrari, D. Tremolada, G. Caselli, and M. Lanza. "Novel analgesic compound CR4056 alleviates mechanical hyperalgesia in a rat model of postoperative pain acting at imidazoline-I2 binding site." Journal of Pain 14, no. 4 (April 2013): S44. http://dx.doi.org/10.1016/j.jpain.2013.01.512.

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7

Hernández-Hernández, Elena, Sandra Ledesma-Corvi, Fernando Yáñez-Gómez, Celia Garau, Laura Gálvez-Melero, Andrea Bagán, Carmen Escolano, and M. Julia García-Fuster. "Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats." Pharmacology Biochemistry and Behavior 223 (February 2023): 173527. http://dx.doi.org/10.1016/j.pbb.2023.173527.

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Comi, Eleonora, Marco Lanza, Flora Ferrari, Valeria Mauri, Gianfranco Caselli, and Lucio Claudio Rovati. "Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis." Journal of Pain Research Volume 10 (May 2017): 1033–43. http://dx.doi.org/10.2147/jpr.s132026.

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9

Sala, Emanuele, Flora Ferrari, Marco Lanza, Chiara Milia, Chiara Sabatini, Albino Bonazzi, Eleonora Comi, Miriam Borsi Franchini, Gianfranco Caselli, and Lucio Claudio Rovati. "Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models." British Journal of Pharmacology 177, no. 14 (April 24, 2020): 3291–308. http://dx.doi.org/10.1111/bph.15049.

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10

Rovati, L., N. J. Probert, T. Blicharski, N. Brambilla, C. Vitalini, F. Girolami, G. Giacovelli, and M. D'Amato. "CR4056, a first-in-class imidazoline-2 receptor ligand analgesic, in pain from knee osteoarthritis phenotypes: a randomized, placebo-controlled, double-blind, phase iia clinical trial." Osteoarthritis and Cartilage 26 (April 2018): S308. http://dx.doi.org/10.1016/j.joca.2018.02.620.

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11

Rovati, L. C., N. Brambilla, T. Blicharski, J. Connell, C. Vitalini, A. Bonazzi, G. Giacovelli, F. Girolami, and M. D'Amato. "Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial." Osteoarthritis and Cartilage 28, no. 1 (January 2020): 22–30. http://dx.doi.org/10.1016/j.joca.2019.09.002.

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12

Sinha, Santosh Kumar, Chandra Mohan Verma, Vinay Krishna, Ramesh Thakur, Barun Kumar, Amit Goel, Surendra Kumar, Ashutosh Kumar, and Mukesh Jitendra Jha. "ALCAPA in an Octogenarian Woman: An Enigma." Cardiology Research 6, no. 3 (2015): 289–91. http://dx.doi.org/10.14740/cr400w.

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13

Waness, Abdelkarim, Amal A. Batoon, Imran Mirza, and Wael Al Mahmeed. "Elusive Cardiac Angiosarcoma in a Young Pregnant Female: Rare Presentation With Fatal Outcome." Cardiology Research 6, no. 3 (2015): 292–96. http://dx.doi.org/10.14740/cr402w.

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14

Morito, Natsumi, Shin-ichiro Miura, Masaya Yano, Yuka Hitaka, Hiroaki Nishikawa, and Keijiro Saku. "Association Between a Ban on Smoking in a Hospital and the In-Hospital Onset of Acute Myocardial Infarction." Cardiology Research 6, no. 3 (2015): 278–82. http://dx.doi.org/10.14740/cr404e.

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15

Kobayashi, Akihiro, Naoki Misumida, John T. Fox, and Yumiko Kanei. "Prognostic Value of Left Ventricular End-Diastolic Pressure in Patients With Non-ST-Segment Elevation Myocardial Infarction." Cardiology Research 6, no. 4-5 (2015): 301–5. http://dx.doi.org/10.14740/cr406w.

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Sinha, Santosh Kumar, Chandra Mohan Verma, Ramesh Thakur, Varun Kumar, Mohit Sachan, Ashutosh Kumar, Mukesh Jitendra Jha, and Vikas Mishra. "Subvalvar Mitral Aneurysm: A Rare Cause of Mitral Leak." Cardiology Research 6, no. 3 (2015): 297–99. http://dx.doi.org/10.14740/cr408w.

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Kumar, Prakash, Gaurav Singhal, Santosh Kumar Sinha, Umeshwar Pandey, Ramesh Thakur, and Chandra Mohan Varma. "Ebstein Anomaly With Right Atrial Clot." Cardiology Research 6, no. 4-5 (2015): 319–23. http://dx.doi.org/10.14740/cr409w.

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18

Paton, Maria, Lisa Ashton, Ian Pearson, and Mohan Sivananthan. "Is Intra-Aortic Balloon Pump Counterpulsation Sufficient to Treat Patients in Cardiogenic Shock, Undergoing Primary Percutaneous Coronary Intervention." Cardiology Research 6, no. 6 (2015): 339–45. http://dx.doi.org/10.14740/cr415w.

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19

Fathala, Ahmed, Mnahi Bin Saeedan, Ali Zulfiqar, and Hani Al Sergani. "Non-Cardiovascular Computed Tomography Incidental Findings in Patients Who Underwent Transaortic Valve Implantation Procedure." Cardiology Research 8, no. 1 (2017): 13–19. http://dx.doi.org/10.14740/cr445w.

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Negreva, Mariya, Svetoslav Georgiev, and Krasimira Prodanova. "Significant Increase in C-Reactive Protein and Serum Amyloid A in the Early Hours of Paroxysmal Atrial Fibrillation." Cardiology Research 7, no. 1 (2016): 1–8. http://dx.doi.org/10.14740/cr455w.

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21

Okahara, Arihide, Kenji Sadamatsu, Taku Matsuura, Yasuaki Koga, Daigo Mine, and Keiki Yoshida. "Coronary Artery Disease Screening With Carotid Ultrasound Examination by a Primary Care Physician." Cardiology Research 7, no. 1 (2016): 9–16. http://dx.doi.org/10.14740/cr456w.

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22

Moshar, Simindokht, Seyedehsara Bayesh, Maryam Mohsenikia, and Reza Najibpour. "The Association of Calcium-Phosphorus Product With the Severity of Cardiac Valves Failure in Patients Under Chronic Hemodialysis." Cardiology Research 7, no. 2 (2016): 80–83. http://dx.doi.org/10.14740/cr465w.

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23

Warriner, David R., Patricia Lawford, and Paul J. Sheridan. "Cardiac Resynchronization Therapy Leads to Improvements in Handgrip Strength." Cardiology Research 7, no. 3 (2016): 95–103. http://dx.doi.org/10.14740/cr475w.

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24

Basman, Craig, Pratik R. Agrawal, Chad McRee, Louis Saravolatz, Carol Chen-Scarabelli, and Tiziano M. Scarabelli. "Diagnostic Approach to Myocarditis Mimicking Myocardial Infarction at Initial Presentation." Cardiology Research 7, no. 6 (2016): 209–13. http://dx.doi.org/10.14740/cr485w.

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25

Sinha, Santosh Kumar, Kush Bhagat, Mohammad Asif, Karandeep Singh, Mohit Sachan, Vikas Mishra, Nasar Afdaali, et al. "Fragmented QRS as a Marker of Electrical Dyssynchrony to Predict Inter-Ventricular Conduction Defect by Subsequent Echocardiographic Assessment in Symptomatic Patients of Non-Ischemic Dilated Cardiomyopathy." Cardiology Research 7, no. 4 (2016): 140–45. http://dx.doi.org/10.14740/cr495w.

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26

Vogt, Matthew R., Bastiaan Moesker, Jaap Goudsmit, Mandy Jongeneelen, S. Kyle Austin, Theodore Oliphant, Steevenson Nelson, et al. "Human Monoclonal Antibodies against West Nile Virus Induced by Natural Infection Neutralize at a Postattachment Step." Journal of Virology 83, no. 13 (April 22, 2009): 6494–507. http://dx.doi.org/10.1128/jvi.00286-09.

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ABSTRACT West Nile virus (WNV) is a neurotropic flavivirus that is now a primary cause of epidemic encephalitis in North America. Studies of mice have demonstrated that the humoral immune response against WNV limits primary infection and protects against a secondary challenge. The most-potent neutralizing mouse monoclonal antibodies (MAbs) recognize an epitope on the lateral ridge of domain III (DIII-lr) of the envelope (E) protein. However, studies with serum from human patients show that antibodies against the DIII-lr epitope comprise, at best, a minor component of the human anti-WNV antibody response. Herein, we characterize in detail two WNV-specific human MAbs, CR4348 and CR4354, that were isolated from B-cell populations of convalescent patients. These MAbs strongly neutralize WNV infection of cultured cells, protect mice against lethal infection in vivo, and yet poorly recognize recombinant forms of the E protein. Instead, CR4348 and CR4354 bind determinants on intact WNV virions and subviral particles in a pH-sensitive manner, and neutralization is altered by mutations at the dimer interface in domain II and the hinge between domains I and II, respectively. CR4348 and CR4354 human MAbs neutralize infection at a postattachment step in the viral life cycle, likely by inhibiting acid-induced fusion within the endosome.

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Bakker, Alexander B. H., Wilfred E. Marissen, R. Arjen Kramer, Amy B. Rice, William C. Weldon, Michael Niezgoda, Cathleen A. Hanlon, et al. "Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants." Journal of Virology 79, no. 14 (July 2005): 9062–68. http://dx.doi.org/10.1128/jvi.79.14.9062-9068.2005.

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ABSTRACT The need to replace rabies immune globulin (RIG) as an essential component of rabies postexposure prophylaxis is widely acknowledged. We set out to discover a unique combination of human monoclonal antibodies (MAbs) able to replace RIG. Stringent criteria concerning neutralizing potency, affinity, breadth of neutralization, and coverage of natural rabies virus (RV) isolates and in vitro escape mutants were set for each individual antibody, and the complementarities of the two MAbs were defined at the onset. First, we identified and characterized one human MAb (CR57) with high in vitro and in vivo neutralizing potency and a broad neutralization spectrum. The linear antibody binding site was mapped on the RV glycoprotein as antigenic site I by characterizing CR57 escape mutants. Secondly, we selected using phage display a complementing antibody (CR4098) that recognized a distinct, nonoverlapping epitope (antigenic site III), showed similar neutralizing potency and breadth as CR57, and neutralized CR57 escape mutants. Reciprocally, CR57 neutralized RV variants escaping CR4098. Analysis of glycoprotein sequences of natural RV isolates revealed that the majority of strains contain both intact epitopes, and the few remaining strains contain at least one of the two. In vitro exposure of RV to the combination of CR57 and CR4098 yielded no escape mutants. In conclusion, a novel combination of human MAbs was discovered suitable to replace RIG.

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28

Li, Xingchen, Yage Xing, Lin Cao, Qinglian Xu, Shaohua Li, Ranran Wang, Zijing Jiang, Zhenming Che, and Hongbin Lin. "Effects of Six Commercial Saccharomyces cerevisiae Strains on Phenolic Attributes, Antioxidant Activity, and Aroma of Kiwifruit (Actinidia deliciosa cv.) Wine." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2934743.

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“Hayward” kiwifruit (Actinidia deliciosa cv.), widely planted all around the world, were fermented with six different commercial Saccharomyces cerevisiae strains (BM4×4, RA17, RC212, WLP77, JH-2, and CR476) to reveal their influence on the phenolic profiles, antioxidant activity, and aromatic components. Significant differences in the levels of caffeic acid, protocatechuate, and soluble solid content were found among wines with the six fermented strains. Wines fermented with RC212 strain exhibited the highest total phenolic acids as well as DPPH radical scavenging ability and also had the strongest ability to produce volatile esters. Wines made with S. cerevisiae BM 4×4 had the highest content of volatile acids, while the highest alcohol content was presented in CR476 wines. Scoring spots of wines with these strains were separated in different quadrants on the components of phenolics and aromas by principal component analyses. Kiwifruit wines made with S. cerevisiae RC212 were characterized by a rich fruity flavor, while CR476 strain and WLP77 strain produced floral flavors and green aromas, respectively. Altogether, the results indicated that the use of S. cerevisiae RC212 was the most suitable for the fermentation of kiwifruit wine with desirable characteristics.

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Companjen, Arjen, Susan M. Moore, Bruno Boulanger, Stefan Kostense, and Wilfred E. Marissen. "Validation of Adapted Neutralization Assays Developed to Discriminate Anti-Rabies Virus Activity of Two Different Anti-Rabies Virus Monoclonal Antibodies Administered as a Combination." Biologics 3, no. 1 (January 19, 2023): 11–21. http://dx.doi.org/10.3390/biologics3010002.

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Assessment of rabies virus (RABV) neutralizing antibodies in subjects vaccinated or injected with anti-RABV immunoglobulins is central in determination of rabies protection. The rapid fluorescent focus inhibition test (RFFIT) is used for assessment of anti-RABV activity in serum. The current anti-RABV polyclonal preparations on the market pose difficulties in production and vary in quality. RABV neutralizing monoclonal antibodies (MAbs) are being evaluated as replacements. Different anti-RABV MAbs may neutralize different RABV isolates, thus two or more MAbs directed against different epitopes on the RABV glycoprotein are needed. It is therefore important to ensure neutralizing activity against all RABV isolates in sera of subjects injected with an anti-RABV MAb product consisting of two or more MAbs. The RFFIT, utilizing CVS-11 as challenge virus, cannot discriminate between the activities of different anti-RABV MAbs. We developed and validated two RFFIT methods enabling specific assessment of two different anti-RABV MAbs (CR57 and CR4098) in using two mutant CVS-11 strains resistant to either CR57 or CR4098 neutralization. The validation results demonstrate that both RFFIT assays using MAb resistant RABV are precise, accurate, linear, specific, and stable within the linear range of 0.025 IU/mL to 1.0 IU/mL. This method design can, therefore, be used to determine MAb specific anti-RABV activity in human serum samples.

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30

Lechtman, Jay, Peter D'Amato, and Julio Alberto Gonzalez Dominguez. "New cultivars: Sarracenia 'Seurat', Sarracenia 'Gorey', Sarracenia 'Leo Song', Sarracenia 'Deep Throat', Sarracenia 'Red and White', Dionaea 'JA1'." Carnivorous Plant Newsletter 40, no. 4 (December 1, 2011): 136–40. http://dx.doi.org/10.55360/cpn404.cr404.

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31

Throsby, Mark, Cecile Geuijen, Jaap Goudsmit, Arjen Q. Bakker, Jehanara Korimbocus, R. Arjen Kramer, Marieke Clijsters-van der Horst, et al. "Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus." Journal of Virology 80, no. 14 (July 15, 2006): 6982–92. http://dx.doi.org/10.1128/jvi.00551-06.

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ABSTRACT Monoclonal antibodies (MAbs) neutralizing West Nile Virus (WNV) have been shown to protect against infection in animal models and have been identified as a correlate of protection in WNV vaccine studies. In the present study, antibody repertoires from three convalescent WNV-infected patients were cloned into an scFv phage library, and 138 human MAbs binding to WNV were identified. One hundred twenty-one MAbs specifically bound to the viral envelope (E) protein and four MAbs to the premembrane (prM) protein. Enzyme-linked immunosorbent assay-based competitive-binding assays with representative E protein-specific MAbs demonstrated that 24/51 (47%) bound to domain II while only 4/51 (8%) targeted domain III. In vitro neutralizing activity was demonstrated for 12 MAbs, and two of these, CR4374 and CR4353, protected mice from lethal WNV challenge at 50% protective doses of 12.9 and 357 μg/kg of body weight, respectively. Our data analyzing three infected individuals suggest that the human anti-WNV repertoire after natural infection is dominated by nonneutralizing or weakly neutralizing MAbs binding to domain II of the E protein, while domain III-binding MAbs able to potently neutralize WNV in vitro and in vivo are rare.

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32

Kostense, Stefan, Susan Moore, Arjen Companjen, Alexander B. H. Bakker, Wilfred E. Marissen, Rie von Eyben, Gerrit Jan Weverling, Cathleen Hanlon, and Jaap Goudsmit. "Validation of the Rapid Fluorescent Focus Inhibition Test for Rabies Virus-Neutralizing Antibodies in Clinical Samples." Antimicrobial Agents and Chemotherapy 56, no. 7 (April 30, 2012): 3524–30. http://dx.doi.org/10.1128/aac.06179-11.

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ABSTRACTMonoclonal antibodies are successful biologics in treating a variety of diseases, including the prevention or treatment of viral infections. CL184 is a 1:1 combination of two human monoclonal IgG1 antibodies (CR57 and CR4098) against rabies virus, produced in the PER.C6 human cell line. The two antibodies are developed as replacements of human rabies immune globulin (HRIG) and equine rabies immune globulin (ERIG) in postexposure prophylaxis (PEP). The rapid fluorescent focus inhibition test (RFFIT) is a cell-based virus neutralization assay which is usually performed to determine the biological potency of a vaccine and to measure the levels of protection against rabies in humans and animals. In order to confirm the suitability of this assay as a pharmacodynamic assay, we conducted a validation using both HRIG- and CL184-spiked serum samples and sera from vaccinated donors. The validation results met all analytical acceptance criteria and showed that HRIG and CL184 serum concentrations can be compared. Stability experiments showed that serum samples were stable in various suboptimal conditions but that rabies virus should be handled swiftly once thawed. We concluded that the assay is suitable for the measurement of polyclonal and monoclonal rabies neutralizing antibodies in clinical serum samples.

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33

Véronique, Siauve, and Pilaire Sophie. "Le CR40, des collections marquées par leur territoire." L’écosystème des ressources continues, no. 88 (January 1, 2018): 8. http://dx.doi.org/10.35562/arabesques.1193.

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34

Ezemonye, L. I. N., D. F. Ogeleka, and F. E. Okieimen. "Desmoscaris tripsinosa and Palaemonetes africanus Responses to Concentrations of Neatex and Norust CR486 in Sediment." Journal of Surfactants and Detergents 10, no. 4 (October 30, 2007): 301–8. http://dx.doi.org/10.1007/s11743-007-1046-2.

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35

Yang, Gang, Yuqian Wei, and HengKui Li. "Acoustic Diagnosis of Rolling Bearings Fault of CR400 EMU Traction Motor Based on XWT and GoogleNet." Shock and Vibration 2022 (November 1, 2022): 1–12. http://dx.doi.org/10.1155/2022/2360067.

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Acoustic diagnosis has been a research hotspot in recent years because of the advantages of noncontact signal acquisition. However, acoustic diagnosis technology has not been applied to bearing fault diagnosis of Electric Multiple Units (EMU) traction motor. Traditional fault diagnosis methods are difficult to diagnose acoustic signals with complex noise. An intelligent fault diagnosis method based on Cross Wavelet Transform (XWT) and GoogleNet model is proposed in this paper. Firstly, the fault feature enhancement algorithm is proposed using XWT and bandpass filtering. Secondly, the CR400 EMU traction motor bearing fault test bed is built to collect real fault acoustic signals from two different positions, then XWT is applied to the original signal to identify the fault feature frequency band, then bandpass filtering is used to filter out the noise frequency band other than the fault feature frequency band. Finally, the kurtosis spectrum of the denoised signal and the original signal are input into GoogleNet, respectively, for fault classification. The result shows that (1) GoogleNet achieves 98.23% accuracy in the fault classification for denoised signals, while only 89.66% accuracy for the original signals. (2) Deep learning is an effective method for the acoustic diagnosis of motor bearing faults in EMU trains.

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Ezemonye, L. I. N., D. F. Ogeleka, and F. E. Okieimen. "Acute toxicity of industrial detergent (Neatex) and corrosion inhibitor (Norust CR486) to early stages of cichlids:Tilapia guineensis." Chemistry and Ecology 23, no. 2 (April 2007): 131–38. http://dx.doi.org/10.1080/02757540701197796.

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37

Kaufmann, B., M. R. Vogt, J. Goudsmit, H. A. Holdaway, A. A. Aksyuk, P. R. Chipman, R. J. Kuhn, M. S. Diamond, and M. G. Rossmann. "Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354." Proceedings of the National Academy of Sciences 107, no. 44 (October 18, 2010): 18950–55. http://dx.doi.org/10.1073/pnas.1011036107.

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38

Mendoza, Zaíra Morais dos Santos Hurtado de, and Pedro Hurtado de Mendoza Borges. "ANÁLISIS COLORIMÉTRICO DEL EXTRACTO ACUOSO DE HOJAS DE TECA1." Revista Árvore 39, no. 5 (October 2015): 953–61. http://dx.doi.org/10.1590/0100-67622015000500018.

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RESUMEN El estudio tuvo como objetivo una evaluación colorimétrica del extracto acuoso de hojas de la base y del ápice de árboles de teca, provenientes de repoblación forestal en Mato Grosso. Los parâmetros utilizados en el sistema CieLab fueron determinados por el colorímetro MINOLTA, modelo CR400. Los extractos acuosos fueron mantenidos a una tasa de calentamiento de 100 ºC por el tiempo de 1 y 2 horas separadamente. En el análisis de los datos se adoptó el delineamento enteramente casualizado (DEC), con 6 repeticiones, en el esquema de parcelas subdivididas. En este caso se consideró como factor principal la posición de la hoja en la copa del árbol y el tiempo de calentamiento como secundario. La luminosidad no presentó diferencias significativas, en función de los factores evaluados. Se observó una pérdida en la pigmentación amarilla de la base para el ápice. Así, se verificó el color amarillo anaranjado en la base y rojo anaranjado en el ápice. Se concluyó que tanto la posición de la hoja en la copa del árbol, cuanto el tiempo de calentamiento influyeron en la coloración de los extractos, siendo 1 hora suficiente para la obtención de los colorantes, independientemente de la posición en la copa.

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Silva, Luíz Guilherme Malaquias da, Henrique Costa Silva Zandomenegui, Brenda Regina Aires Vieira, Marcela Costa Rocha, and Aline Manke Nachtigall. "Análise de cor e aceitabilidade de molho agridoce de abacaxi com pimenta elaborado com diferentes espessantes." Research, Society and Development 10, no. 1 (January 14, 2021): e32010111871. http://dx.doi.org/10.33448/rsd-v10i1.11871.

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A demanda elevada por alimentos saudáveis é um fator relevante para o desenvolvimento de produtos alimentícios. Neste sentido, os vegetais são ricos em nutrientes que lhes conferem propriedades funcionais. Portanto, objetivou-se elaborar um molho para carnes, de abacaxi com pimenta, e avaliar a sua coloração e aceitabilidade sensorial. Foram elaboradas três formulações com as mesmas condições de processamento e variação nos espessantes empregados (F1 - Goma Xantana; F2 – Goma Carragena; F3 – Carboximetilcelulose). Os molhos foram elaborados pela mistura dos ingredientes a frio. Avaliaram-se os parâmetros instrumentais de cor (L*, a*, b*, H°, C*), com colorímetro Minolta CR400. O teste de aceitação dos atributos aroma, cor, sabor, consistência e aspecto global, foi realizado fazendo uso de uma escala hedônica de 9 pontos e o teste de intenção de compra com escala de atitude de 5 pontos, ambos com 80 consumidores. Os molhos apresentaram coloração amarela, com maior luminosidade (45,38) e intensidade (39,55) de cor observada no molho elaborado com Goma Carragena, enquanto a maior tonalidade (85,02) foi percebida no molho produzido com Goma Xantana. Os molhos apresentaram boa aceitação para todos os atributos, com índice de aceitabilidade superior a 70%, exceto para a consistência do molho elaborado com Goma Carragena (67%). Não foram verificadas diferenças significativas entre a intenção de compra das amostras (F1- 3,70; F2- 3,54; F3- 3,43). Portanto, o estudo demonstra a importância da escolha do espessante para a elaboração de molhos e a necessidade de adequação da formulação elaborada com a Goma Carragena.

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Grzonka, Justyna, Ryszard Mania, János L. Lábár, and Jerzy Morgiel. "Effect of Silicon Additions in CrSi (10, 20, 30, 40 at. % Si) Magnetron Targets on Microstructure of Reactively Deposited (Cr,Si)N Coatings." Solid State Phenomena 186 (March 2012): 182–87. http://dx.doi.org/10.4028/www.scientific.net/ssp.186.182.

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The CrSi compacts containing 10, 20, 30 and 40 at. % Si sintered from mixed elemental powders were used as targets for reactively deposited magnetron (Cr,Si)N coatings. The silicon substrates were kept either at ambient temperature or heated up to 600 °C. The microstructure observations were performed using TECNAI FEG (200 kV) with EDAX X-ray Energy Dispersive Spectroscopy (EDS) system and JEOL 3010 (300 kV) with Gatan Energy Filtering (GIF) attachment microscopes. The thin foils were cut using QUANTA Focused Ion Beam (FIB) system. The performed investigations proved that increasing silicon content in coatings deposited at 600 °C using CrSi10, CrSi20 and CrSi30 targets caused a refining of their fully crystalline CrN-type columnar microstructure from ~ 40 to ~ 35 and ~ 25 nm. The deposition performed from the same targets, but at ambient temperatures, i.e. without resistive heating of the substrates, produced coatings of mixed crystalline-amorphous type. They were characterized by gradient microstructure, i.e. amorphous material was prevailing close to the substrate and decreasing close to coating surface. The rising of silicon content in the targets resulted in decreasing amount of crystalline phase. The coatings obtained from Cr40Si target were fully amorphous independently of substrate temperature during deposition. The measurements of local chemical compositions obtained using EDS technique indicated that the Cr:Si ratio in the coatings roughly reproduced that present in the targets used for their deposition. Additionally, these measurements indicated that all coatings are contaminated with oxygen. The mapping of chemical composition using GIF technique of mixed crystalline-amorphous coatings proved that they are enriched in Cr and Si, respectively. The present results showed, that relying on single CrSi target magnetron sputtering the crystalline-amorphous nano-composite could be obtain at silicon additions from 10 to 30 at %, i.e. well above were that type of microstructure is formed during deposition using double target magnetron systems. Additionally, for the first time, the measurements helped to prove that the crystallites and amorphous material are enriched in chromium and silicon respectively, i.e. confirmed presence of CrN/Si3N4 composite.

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T. N. I., KONI, and M. SITU. "FIBER FRACTION OF KEPOK BANANA PEEL FLOUR (Musa paradisiaca) FERMENTED BY GOAT RUMENT FLUIDS." Majalah Ilmiah Peternakan 25, no. 1 (February 28, 2022): 13. http://dx.doi.org/10.24843/mip.2022.v25.i01.p03.

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This experiment was conducted to evaluate the fiber fraction of banana peel meal fermented by goat rumen flu- id. The experimental design used was completely randomized design with four treatments and six replicates. Four treatments were CR0: kepok banana peel meal + 0% goat rumen fluid, CR30: kepok banana peel meal + 30% goat rumen fluid, CR40: kepok banana peel meal + 40% goat rumen fluid, CR50: kepok banana peel meal + 50 % goat rumen fluid. This fermentation process during seven days. The variables observed were NDF, ADF, hemycellulosa, cellulose, and lignin. The data on the fiber fraction of banana peel meal was analyzed by analysis of variance and continued with Duncan s multiple range tests. NDF, ADF, cellulose, hemicellulose, and lignin of banana peel meal fermented by goat rumen fluid was lower than that without goat rumen fluid. The conclusion in this study was that the use of 30% goat rumen fluid contained ADF of 31.84%, NDF of 45.03%, cellulose of 13.27% and hemicellulose of 13.53% of kepok banana peel meal.

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Kumar, Dinesh Kant, Behzad Aliahmad, Hao Hao, Mohd Zulfaezal Che Azemin, and Ryo Kawasaki. "A Method for Visualization of Fine Retinal Vascular Pulsation Using Nonmydriatic Fundus Camera Synchronized with Electrocardiogram." ISRN Ophthalmology 2013 (March 10, 2013): 1–9. http://dx.doi.org/10.1155/2013/865834.

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Pulsatile changes in retinal vascular geometry over the cardiac cycle have clinical implication for diagnosis of ocular and systemic vascular diseases. In this study, we report a Vesselness Mapping of Retinal Image Sequence (VMRS) methodology to visualize the vessel pulsation and quantify the pulsatile motions in the cardiac cycle. Retinal images were recorded in an image sequence corresponding to 8 segments of the cardiac cycle using a nonmydriatic fundus camera (Canon CR45, Canon Inc., Japan) modified with ECG-synchronization. Individual cross-sectional vessel diameters were measured separately and the significance of the variations was tested statistically by repeated measures analysis of variance (ANOVA). The graders observed an improved quality of vessel pulsation on a wide region around the optic disk using the VMRS. Individual cross- sectional vessel diameter measurement after visualization of pulsatile motions resulted in the detection of more significant diameter change for both arterioles (3.3 μm, P=0.001) and venules (6.6 μm, P<0.001) compared to individual measurement without visualization of the pulsatile motions (all P values > 0.05), showing an increase of 2.1 μm and 4.7 μm for arterioles and venules, respectively.

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Hércules, Stael, Marina Komeroski, Raisa Homem, Helena Schmidt, Larissa de Lira, Deise Farias, Alessandro Rios, and Viviani Oliveira. "Milk Proteins As Alternatives of Reducing Sugar in Cookies: Chemical and Technological Approaches." Current Developments in Nutrition 5, Supplement_2 (June 2021): 586. http://dx.doi.org/10.1093/cdn/nzab044_017.

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Abstract Objectives This work aimed to evaluate nutritional and technological characteristics of cookies with low sugar content and added with milk proteins. Methods The cookies samples were made and evaluated at the Dietetic Laboratory and at the Bioactive Compounds Laboratory of the Institute of Food Science of Federal University of Rio Grande do Sul (UFRGS).Five formulations were made: S- standard; NC- casein and sugar reduction; NW- whey protein and sugar reduction; CC- casein, cocoa and sugar reduction; CW- whey protein, cocoa and sugar reduction. The doughs were mixed, kneaded, and the cookies placed in rectangular baking trays. A conventional oven was previously preheated for 20 minutes under 180°C and then the cookies were baked for 15 minutes under 180°C. Physical analysis was performed on cookies at room temperature (23°C), before and after baking, in order to determine weight, height, diameter, weight loss, yield, apparent volume, specific volume and spread ratio.The color of cookies was measured by a colorimeter (Chrona Meter CR400 model). All readings were performed in triplicate, and the equipment sensor was placed carefully on the samples. Hardness determination of the cookies was performed on a TA.XT2 texturometer. The proximate composition was evaluated on samples after baking. The analyses carried out were moisture, ashes, lipids, proteins and were performed in triplicate. Results The cookies developed in this work presented similar technological quality for apparent volume, specific volume, spread ratio and yield. High protein and ashes content, lower moisture and low sugar concentration were also observed. NW presented similar luminosity, appearance, texture and color when compared to the treatment S. Casein treatments NC and CC did not emerge as good cookie formulations, did not show promising technological and was not considered a viable alternative, unlike cocoa powder, which possibly covered up the sugar shortage and proved to be a promising ingredient in cookie formulation. Conclusions Based on the analyses performed in the present study, it can be suggested that the cookies made with low sugar content and added with WP had appropriate chemical and technological characteristics as a new alternative. Funding Sources We are grateful to Universidade Federal do Rio Grande Sul (UFRGS), CNPq and CAPES for providing scholarship to our researchers.

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Puja, Giulia, Gabriele Losi, Lucio Rovati, Marco Lanza, Gianfranco Caselli, and Rita Bardoni. "Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties." Frontiers in Pain Research 3 (September 22, 2022). http://dx.doi.org/10.3389/fpain.2022.1003068.

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CR4056 is an imidazoline-2 receptor ligand having potent analgesic activity and synergistic effect with opioids. Very recently it has been found that CR4056 can revert the cognitive impairment in animal models of Alzheimer's disease (AD). Since several lines of evidence highlight the importance of NMDAR modulators in nociceptive signaling and in AD progression, we considered as important to investigate the effects of CR4056 on NMDAR activity. In primary culture of cortical neurons, application of NMDA and glycine elicits a current that is decreased in a dose-dependent fashion by CR4056 (IC50 5.3 ± 0.1 µM). CR4056 antagonism is reversible, not competitive and voltage-independent and it is not blocked by pertussis toxin. CR4056 interacts with the co-agonist glycine site in a competitive way, indeed high glycine concentrations diminish its effect. Fibroblasts expressing different recombinant NMDA receptors are differently modulated by CR4056: the potency and the efficacy of the compound are higher in GluN1- GluN2B than in GluN1-GluN2A containing receptors. In lamina II neurons of spinal cord slices, single stimulation of afferent fibers evokes an NMDA-mediated current that is inhibited by 10 µM CR4056. Repetitive stimulation of the dorsal root at high frequency and high intensity produces a firing activity that is significatively depressed by CR4056. Taken together, our results broad the understanding of the molecular mechanisms of CR4056 analgesic activity, involving the modulation of NMDAR activity. Therefore, we propose that the analgesic action of CR4056 and the neuroprotective effects in AD models may be mediated also by NMDAR inhibition.

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Qiu, Yanyan, Xiao-Hua He, Yanan Zhang, and Jun-Xu Li. "Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats." Scientific Reports 4, no. 1 (October 13, 2014). http://dx.doi.org/10.1038/srep06605.

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Caselli, Gianfranco, Meregalli, Ceresa, Canta, Carozzi, Chiorazzi, Sala, et al. "CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats." Journal of Pain Research, June 2012, 151. http://dx.doi.org/10.2147/jpr.s32122.

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Lanza, Marco, Ferrari, Fiorentino, Mennuni, Garofalo, Letari, Mandelli, Giordani, and Caselli. "Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain." Journal of Pain Research, April 2011, 111. http://dx.doi.org/10.2147/jpr.s18353.

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Barboni, Paulo. "n. 185 (16): Dor On Line." Dor on line, no. 185 (December 31, 2015). http://dx.doi.org/10.26512/dol.v0i185.16478.

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Edição de Setembro de 2015 - Ano 16 - Número 182 Prezados leitores, finalizando o ano de 2015, trazemos nesta edição os trabalhos apresentados no Quinto Congresso Internacional em Dor Neuropática da IASP, realizado de 14 a 17 de maio de 2015, em Nice, França. Ainda, acompanhando esta edição, temos um editorial tratando sobre o canal de sódio Nav1.9 e seu papel na inflamação e na dor neuropática. Boa Leitura! Editorial No Gain, No Pain! Nav 1.9: uma nova arma para o tratamento da dor? Larissa Garcia Pinto Trabalhos apresentados no Quinto Congresso Internacional em Dor Neuropática da IASP, realizado de 14 a 17 de maio de 2015. Neuroesteróides são potenciais novos agentes analgésicos para dor neuropática do diabetes. Simone Aparecida Antoniazi Pereira Comportamento de ansiedade e prejuízo no Locus Coeruleus em dois modelos de neuropatia em ratos: um estudo comparativo. Alexandre Hashimoto Pereira Lopes Envolvimento do receptor de insulina IGF1 no tratamento de neuropatia diabética. Jozi Godoy Figueiredo Citidina 5-difosfocolina (citicolina) inibe a dor neuropática e a expressão de canais de sódio Nav 1.7 após lesão do nervo ciático por esmagamento. Anne Karoline Schreiber A separação materna no período neonatal pode servir como modelo animal relevante para estudar a fibromialgia? Cássia Regina da Silva Caracterização farmacológica da eficácia analgésica do CR4056, um novo ligante do receptor imidazoline-2. Andressa Daiane de Carvalho Zaparolli Gabapentina reduz nocicepção em modelo de osteoartrite em roedor: isto seria um componente neuropático da dor por osteoartrite? Rangel Leal Silva O papel da CASPR2 na regulação de sensibilidade dolorosa. Alexandre Hashimoto Pereira Lopes TRPA1 contribui para hiperalgesia facial ao frio induzida por capsaicina em ratos. David Wilson Ferreira Comorbidades na neuropatia dolorosa e silenciosa. Miriam das Dores Mendes Fonseca

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Kolchin, N. N., A. G. Ponomarev, and V. N. Zernov. "Новая техника для картофелеводства." Kartofel` i ovoshi, no. 6 (June 7, 2019). http://dx.doi.org/10.25630/pav.2019.77.31.006.

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Представлены новые современные модели машин: универсальный навесной культиватор-гребнеобразователь КГП-4; картофелепосадочная машина CR450M с возможностью совмещения ряда технологических операций (подготовка почвы, посадка, гребнеобразование, опрыскивание, локальное внесение гранулированных удобрений и защита от эрозии); оригинальный комбайн Spirit 5200 бункерного типа; намеченный к серийному производству безбункерный комбайн (копатель–погрузчик) AVR Lynx.Modern and reliable machinery and innovative machine technologies for potato production are key factors in improving potato production efficiency. The current conditions of potato production in Russia show that medium-sized complexes are the most popular and widespread today. A number of Russian enterprises together with foreign partners are trying to revive the production of potato equipment in our country of medium size at a new level. The article presents new modern models of machines universal mounted cultivator-comb-forming cultivator KGP-4; potato-planting machine CR450M with the possibility of combining a number of technological operations (soil preparation, planting, combing, spraying, local application of granular fertilizers and protection against soil erosion); original combine Spirit 5200 bunker type; scheduled for mass production without a bin harvester (digger- loader) AVR Lynx.

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Huang, Fei, Meishen Ren, Jie Pei, Hong Mei, Baokun Sui, Qiong Wu, Benjie Chai, et al. "Preexposure and Postexposure Prophylaxis of Rabies With Adeno-Associated Virus Expressing Virus-Neutralizing Antibody in Rodent Models." Frontiers in Microbiology 12 (August 19, 2021). http://dx.doi.org/10.3389/fmicb.2021.702273.

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Rabies, a fatal disease in humans and other mammals, is caused by the rabies virus (RABV), and it poses a public health threat in many parts of the world. Once symptoms of rabies appear, the mortality is near 100%. There is currently no effective treatment for rabies. In our study, two human-derived RABV-neutralizing antibodies (RVNA), CR57 and CR4098, were cloned into adeno-associated virus (AAV) vectors, and recombinant AAVs expressing RVNA were evaluated for postexposure prophylaxis after intrathecal injection into RABV-infected rats. At 4days post-infection with a lethal dose of RABV, 60% of the rats that received an intrathecal injection of AAV-CR57 survived, while 100% of the rats inoculated with AAV-enhanced green fluorescent protein (EGFP) succumbed to rabies. Overall, these results demonstrate that AAV-encoding RVNA can be utilized as a potential human rabies postexposure prophylaxis.

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