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Djakovitch, Laurent. "L'activation des arènes par le greffon CpFe+ : synthèse d'arbres moléculaires réservoirs polyélectroniques." Bordeaux 1, 1995. http://www.theses.fr/1995BOR10515.
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Dans ce memoire, nous decrivons une approche originale de synthese d'arbres moleculaires utilisant une voie organometallique. En effet, la complexation des composes aromatiques par le greffon cpfe#+ permet conjointement l'activation de groupes methyles portes par le noyau aromatique (reaction de peralkylation), l'activation de fonctions soit halogenees (substitution nucleophile aromatique), soit ether aromatique (reaction de coupure de la fonction ether). Utilisant ces possibilites, nous avons developpe la synthese de noyaux polyfonctionnels (oh, i) de multiplicite 3, 6 ou 9 et d'un synthon phenol poly-fonctionnel de progression 3, qui peut etre obtenu soit complexe au greffon cpfe#+, soit purement organique apres photolyse. Ceci a permis la synthese de composes polymetalliques comportant jusqu'a neuf centres redox transferant leur electron au meme potentiel. De facon similaire, l'obtention du phenol para tri-allyle a permis la synthese d'arbres moleculaires comportant 9, 18 et 27 fonctions ethyleniques peripheriques grace a la progression 3 qu'il introduit a partir des noyaux poly-iodes. Ces travaux ont ouvert la voie a de nombreuses perspectives en cours de developpement dans notre groupe de recherche
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Rabaa, Hassan. "Etude theorique de l'activation de liaisons sigma par des entites organometalliques mononucleaires et structure electronique de complexes cpfe(arene)." Rennes 1, 1987. http://www.theses.fr/1987REN10063.
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Aspects theoriques de l'interaction entre liaison sigma (h-h, c-h, si-h) et des entites organometalliques, et,en particulier, de la nature de la liaison tricentrique mnsih dans cpmnl::(2)hsir::(3); conclusions concernant la plus ou moindre grande facilite de reaction d'addition oxydante de la liaison sigma a des entites ml::(n) d**(n). Etude du mecanisme d'activation h-h et c-h par des complexes cp::(2)mr d**(o) et du mode de coordination de l'etat de transition. Etude de la structure electronique des composes cpfe (arene polyaromatique) par les methodes de hueckel generalisee et scf-ms-xalpha : comparaison des resultats concernant la localisation de l'orbitale contenant l'electron celibataire aux valeurs obtenues par voie electrochimique
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Rabaa, Hassan. "Etude théorique de l'activation de liaisons o par des entités organométalliques mononucléaires et structure électronique de complexes CpFe (arène)." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37609076s.
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Purushottam, Raj Purohit Ravi Raj Purohit. "Understanding mechanical size effects in metallic microwires : synergy between experiment and simulation." Thesis, Poitiers, 2018. http://www.theses.fr/2018POIT2290/document.
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Les microfils métalliques polycristallins produits par étirage à froid présentent une résistance mécanique significative en faisant des candidats idéaux pour les renforts de composites. Des études antérieures sur des fils de nickel polycristallin pur ont montré une dépendance importante par rapport à la taille de la limite d'élasticité et de la résistance à la traction, ainsi que de la ductilité.Le but de cette étude est de comprendre cet effet de la taille dans les microfils de nickel pur polycristallin par analyse de diffraction des rayons X in-situ (DRX) et simulations de la plasticité cristalline par éléments finis (CPFE). Des essais de traction monotone et cyclique in-situ sous rayonnement synchrotron ont été réalisés sur des microfils de diamètres allant de 100 à 40 μm. Les fils étirés à 100 micromètres obtenus dans le commerce présentent une architecture cœur-coquille avec une texture de fibre <111> dominante dans le cœur et une texture à double fibre hétérogène <111> et <100> dans la coquille. La réduction de la taille de l'échantillon par polissage électrolytique conduit à des fils ayant une microstructure homogène, tandis que la réduction de la taille de l'échantillon par un étirage à froid supplémentaire conduit à des fils avec une texture plus intense tout en conservant l'architecture cœur-coquille.La limite d'élasticité et la résistance à la traction des fils électropolis augmentent avec la diminution du diamètre, tandis que la ductilité diminue avec la réduction du diamètre. Dans le cas des fils étirés à froid, on observe que la limite d'élasticité et la résistance à la traction, ainsi que la ductilité, augmentent avec la diminution du diamètre. L'analyse DRX indique une plasticité successive des familles de grains sous iso-déformation. Nous avons observé que le gradient de la texture du microfil active des mécanismes de déformation qui ne sont pas observés pour les microfils à texture homogène. Pour comprendre l'influence de différents paramètres microstructuraux, notamment l'influence de la texture cristallographique, une microstructure représentative 3D a été générée et des simulations CPFE ont été réalisées. Le comportement simulé moyen des différentes familles de grains (<111>, <100>) concorde bien avec les résultats expérimentaux. La simulation CPFE indique une hétérogénéité du champ de contrainte à travers la microstructure en présence d'un gradient de texture cristallographique.Nous montrons que la micro-texture (texture simple ou double texture) et leur dispersion spatiale (homogène ou architecturée) peuvent être utilisées comme stratégie de conception pour obtenir une microstructure optimale en fonction de l’ensemble désiré de propriétés mécaniquesPolycrystalline metallic microwires produced by cold-drawing exhibit significant mechanical strength that make them ideal candidates for reinforcement of composites. Previous studies on polycrystalline pure nickel wires have indicated a significant size dependence of their yield and tensile strength as well as their ductility. The aim of this study is to understand these size effects by in-situ X-ray diffraction (XRD) analysis and crystal plasticity finite element (CPFE) simulations. In-situ monotonous and cyclic tensile tests under synchrotron radiation were carried on microwires with diameters ranging from 100 to 40 µm. The commercially obtained 100µm as-drawn wires exhibit a core-shell architecture with <111> fiber texture dominant in core and heterogeneous dual fiber texture <111> and <100> in the shell. Reduction of specimen size by electropolishing leads to wires having a homogeneous microstructure, whereas reduction of specimen size by further cold drawing leads to wires with a sharper texture while retaining the core-shell architecture.The yield and tensile strength of the electropolished wires increase with decreasing diameter, whereas the ductility decrease with decreasing diameter. In the case of cold-drawn wires, the yield and tensile strength, and also the ductility was observed to increase with decreasing diameter. The XRD analysis indicates successive yielding of grain families under iso-strain condition. The gradient in the texture of the microwire was seen to activate deformation mechanisms which are not seen for microwires with homogeneous texture. To understand the influence of different microstructural parameters, and notably the influence of crystallographic texture, 3D representative microstructure was generated and CPFE simulations were carried out. The simulated average behavior of different grain families (<111>, <100>) agrees well with the experimental results. The CPFE simulations indicate heterogeneity in stress field across the microstructure in the presence of a gradient in crystallographic texture.We show that the microstructure engineering of micro-texture components (single- or dual-texture) and their spatial spread (homogenous or architectured) can be used as design guidelines for obtaining optimal microstructure in accordance with desired set of mechanical properties
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Cristea, Emilian, and Hassan Gelle Khalif. "Critical success factors of potential CPFR implementations : Two manufacturing case studies in Sweden based on a pre-CPFR stage from the perspective of a buyer – seller relationship." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Centre of Logistics and Supply Chain Management (CeLS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39767.
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Background: Higher global competition and more demanding customers force manufacturing companies to develop and adopt new collaborative strategies; the collaborative planning, forecasting and replenishment concept allows stronger supply chain cooperation, cost saving, improved efficiency and performance. Purpose: Exploratory, to study the criticality of factors that can affect the feasibility of a potential a CPFR implementation in Sweden, from the perspective of a manufacturer in a pre-CPFR implementation stage.Method: Qualitative research, using a multiple case method of two manufacturing firms operating in Sweden. Using content analysis, it revolves around studying factor criticality, all the while showing differences and commonalities in terms capabilities, and future feasibility of CPFR between the two case studies. Findings: High degree of interconnectivity between the factors; the critical success factors for Sweden are relationship and trust, goal alignment, KPI’s and costs, with very important factors such as cross-functional communication, top management support, and lower impacting factors such as IT infrastructure and change management. Relationship and trust, cross-functional communication and change management are developed factors that the Swedish manufacturing firms possess. Implications: The study’s contributions are related to the criticality of factors that can affect CPFR implementations in Sweden’s manufacturing sector, showing the importance of each, contributing academically in attempting to fill in the gap related to CPFR in Sweden, and practically by allowing better strategic decision-making in relation to future implementations. This is even more relevant due to a thorough lack of research in this area.
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Quintero, Eduardo, and Zhilin Li. "Importance of CPFR implementation in SME : Discovering the need and insights of CPFR as a supply chain strategy." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-13223.
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This thesis intended to evidence the need for change in a SME to reduce levels of inventory based on their process related to their supply chain management. This research focused on CPFR which is a process innovation tool that stands for collaborative planning, forecasting and replenishment (Cassivi, 2006). The idea behind this process is to make collaborative actions on all members of the supply chain to come up with a share vision and objective. Based on the core concept of this process partners along the supply chain share information based on customer trends and needs to create a single forecast that is visualize at all times by its members to react accordingly to sudden changes in demand. The research´s main objective is to describe the main process needed for CPFR implementation in actual SME that is struggling in a supply chain that is under constant pressure and obtain insight on the benefits involved in this process to reduce levels of inventory. The research was made based on the concept of CPFR through the use of databases such as Google scholar to come up with a first idea of the concept and examples of other companies implementing CPFR as a their main process for their supply chain. The second approach was to contact the companies involved in our case and use questionnaires to identify the relationship and the problems involved in their supply chain structure. This methodology was used to establish a comparison between what has been done in other companies and what is needed in our case company. The companies involved in the research are a SME and a large manufacturer. The large manufacturer is working under CPFR but with final retailers setting aside the value of incorporating upstream suppliers. Due to bullwhip effect upstream suppliers are incrementing their warehousing facilities to react to changes on the demand. This is incrementing the cost of the operation and it is creating an unstable supply. The research demonstrated companies in where CPFR is proven to reduce stockouts, markdowns, levels of inventory, time to market, strengthen the relationship and overall reduce costs. Based on the discoveries in the retail industry it was clear the benefits from this process. Companies such as Condis revealed important information based on incorporating upstream suppliers. At the end observations were made based on implementation strategies such as following the 9 step guidelines set up by VICS, developing pilot programs, reducing the number of SKU´s at the beginning, working on seasonal products rather than standard products, and developing and implementing better IT systems to manage the level of information needed.
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Quispe, Munarriz Katia. "“FACTORES PREDICTORES DE COLEDOCOLITIASIS EN PACIENTES SOMETIDOS A COLANGIOGRAFÍA RETRÓGRADA ENDOSCÓPICA EN EL HOSPITAL LUIS SAENZ-PNP”." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/744.
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OBJETIVOS: Determinar los factores predictores de coledocolitiasis. MATERIAL Y METODOS: Se realizó un estudio descriptivo, correlacional en el Hospital Luis N. Saenz – PNP, durante el periodo de Julio del 2014 a Junio del 2015. Se incluyeron a pacientes sometidos a CPRE por sospecha de coledocolitiasis. Se tomaron parámetros: sexo, edad, clínica del paciente, exámenes de laboratorio y exámenes de imagen. En el análisis estadístico, se tomaron medidas de frecuencia y porcentajes, posteriormente se procedió a realizar un estudio bivariado de asociación con p<0,05 y finalmente calcular la sensibilidad, especificidad, VPP y VPN para cada una de las pruebas diagnósticas.
RESULTADOS: Se obtuvieron datos de 45 historias clínicas de pacientes con indicación de CPRE por sospecha de coledocolitiasis, 27 mujeres (60%) y 18 hombres (40%), con una relación hombre/mujer de 1/1,5, la mediana de edad fue de 66 años. Se hallaron 33 pacientes (73,3%) con coledocolitiasis, de los cuales 23 (69,7%) no eran colecistectomizados. En el análisis univariado las alteraciones más frecuentes fueron dolorabilidad abdominal en el 100% de pacientes, seguido de coledocolitiasis por CRMN en 40 pacientes (88,9%) y bilirrubina directa alterada en 39 pacientes (88,7%). Además el estudio por ecografía reveló la coexistencia de Colelitiasis en el 71,1%. En el análisis bivariado con niveles de p<0,05 la Fosfatasa alcalina y la Gammaglutamiltranspeptidasa, obtuvieron un OR de 4,6 y 7,8 respectivamente. Dentro de las complicaciones la Pancreatitis aguda se encontró en un 18,2%. CONCLUSIONES: La Fosfatasa alcalina y la Gammaglutamiltranspeptidasa demostraron ser pruebas de laboratorio más certeras para predecir coledocolitiasis.
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Dueñas, Nicolau María Belén. "ISO 9001 en el CPCE de Mendoza." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Económicas, 2015. http://bdigital.uncu.edu.ar/7512.
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El Consejo Profesional de Ciencias Económicas de Mendoza fue fundado en 1947, desde
entonces brinda servicios a sus matriculados y a la sociedad.
Durante estos 68 años, el número de profesionales afectados a esta organización ha crecido
vertiginosamente y la organización con ellos. Sin embargo se ha llegado a un punto de inflexión en
el que resulta necesaria una estructura más dinámica. Un sistema que colabore con la velocidad y
calidad en la prestación de sus servicios, sin dejar de lado la eficiencia.
En este trabajo se propone el diseño e implementación de un Sistema de Gestión de Calidad
según la norma ISO 9001:2008 que propone que “la existencia, aplicación y revisión sistemática
de los procedimientos del Sistema de Gestión de Calidad provoca la Mejora Continua" lo que
facilita la prestación de servicios bajo las condiciones mencionadas anteriormente.
El objetivo es redactar los procedimientos del Sistema de Gestión de Calidad, necesarios
para su implementación en el CPCE de Mendoza.Fil: Dueñas Nicolau, María Belén. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.
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Wu, Shiyi. "Corba version of Concordia Parallel Programming Environment (CPPE)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0003/MQ59356.pdf.
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Ahuja, Irene. "Computerized Provider Order Entry (CPOE) using Systems Engineering." Digital Commons at Loyola Marymount University and Loyola Law School, 2013. https://digitalcommons.lmu.edu/etd/342.
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As engineering in the 21st century becomes increasingly politically, socially and technically complex, systems engineering has become an effective tool in managing multidimensional problems involving people and the services they use. This project addresses how systems engineering principles are invoked throughout the development of the Computerized Provider Order Entry (CPOE) process, a subset of Electronic Medical Records (EMR) and presents factors necessary for the successful implementation of CPOE. Through the review of current literature and interviews with CPOE vendor implementers, this paper explains how systems engineering, which has historically been used in the development of systems, products, manufacturing and missions, is evolving into service-oriented industries such as healthcare to manage complex development of EMR systems. The goal of this paper is to show that CPOE implementation is a necessary change for healthcare providers, even though the task may seem daunting. This paper demonstrates that by studying the systems engineering strategies that have worked for CPOE implementation at other organizations, future organizations can also find success.
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Stoll, Robert G. "Collaborative Planning Forecasting Replenishment (CPFR): Successful Implementation Attributes." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1292517604.
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Leandro, Neto Benedito. "Solitons de Yamabe e métricas CPE." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.11.T.19359.
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Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Exatas, Programa de Pós-Graduação em Matemática, 2015.Submitted by Patrícia Nunes da Silva (patricia@bce.unb.br) on 2016-01-26T14:54:49Z No. of bitstreams: 1 2015_BeneditoLeandroNeto_Parcial.pdf: 248614 bytes, checksum: aa0e94e4558b4314ccdb73a1bce22eaf (MD5)
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Provamos que (anti)self dual solitons gradientes (quasi) Yamabe com curvatura seccional positiva são rotacionais simétricos. Além disso, mostramos que, (anti)self dual solitons gradientes de Yamabe tem uma estrutura de produto torcido muito particular desde que a função potencial não tenha pontos críticos. Consideramos solitons gradientes de Yamabe conformes a espaços pseudo-Euclidianos n-dimensionais. Caracterizamos todos os solitons que são invariantes pela ação de um grupo de translação (n-1)-dimensional e obtemos os solitons tipo estável. Como aplicação, obtemos um exemplo de soliton gradiente de Yamabe estável completo, conforme a um espaço Lorentziano. Investigamos também os pontos críticos do funcional curvatura escalar total restrito a um espaço de métricas com curvatura escalar constante e volume unitátio que denotamos por métricas CPE. Foi conjecturado nos anos 1980 que toda métrica CPE é, necessariamente, Einstein. Provamos que métricas CPE, no caso de dimensão quatro, com tensor W+ harmônico são isométricas à esfera S4 dada uma condição integral. No caso n-dimensional, provamos uma condição necessária e suficiente sobre a norma do gradiente da função potencial para que a métrica CPE seja Einstein.
We prove that an (anti)self dual quasi Yamabe gradient soliton with positive sectional curvature is rotationally symmetric. We also prove that four dimensional (anti) self dual gradient Yamabe soliton has a special warped product structure provided that the potential function has no critical points. We consider gradient Yamabe solitons, conformal to an n-dimensional pseudo-Euclidean space. We characterize all such solitons which are invariant under the action of an (n-1)-dimensional translation group and we obtain the steady solitons. Applications provide an explicit example of a complete steady gradient Yamabe soliton, conformal to the Lorentzian space. We also investigate the critical points of the total scalar curvature functional restricted to space of metrics with constant scalar curvature of unitary volume, for simplicity CPE metrics. It was conjectured in the 1980's that every CPE metric must be Einstein. We prove that a 4-dimensional CPE metric with harmonic tensor W+ must be isometric to a round sphere S4 provided an integral condition is satisfied. We also give a necessary and sufficient condition on the norm of the gradient of the potential function for a CPE metric to be Einstein.
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Segura, Mejía María de Fátima, and Cerón José Amado Vázquez. "“Uso de Midazolam y Fentanilo requerido para obtener sedoanalgesia adecuada en la realización de colangiopancreatografía retrógrada endoscópica en pacientes del Centro Médico Lic. Adolfo López Mateos del 07 de marzo del 2012 al 07 de septiembre del 2012.”." Tesis de Licenciatura, Medicina-Quimica, 2013. http://ri.uaemex.mx/handle/123456789/14220.
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OBJETIVO: Determinar si con la dosis de Midazolam 20 mcg/kg de peso ideal y
Fentanilo 2 mcg/kg de peso real, se logra sedación y analgesia adecuada que
permita la realización de Colangiopancreatografía retrógrada endoscópica con un
mínimo de eventos adversos asociados a la sedación.
DISEÑO: Es un ensayo clínico controlado, no aleatorizado, ni segado.
MATERIAL Y MÉTODO: Se estudiarón 50 pacientes de género indistinto, edad
entre 18 y 65 años, con valoración preanestésica ASA I o II, a quien se realizó
colangiopancreatografía retrógrada endoscópica, en el Centro Médico Lic. Adolfo
López Mateos, del 07 de marzo del 2012 al 07 de septiembre del 2012. Se
administró dosis de sedoanalgesia con midazolam 20 mcg/kg de peso ideal y
fentanilo 2 mcg/kg de peso real, se evaluó el grado de sedación obtenido con la
escala de Ramsay y el grado de analgesia con la escala de EVA. También se
obtuvo la dosis de medicamentos, grado de sedación y analgesia requerida para
la CPRE. Así como la existencia de eventos adversos con las dosis utilizadas.
RESULTADOS: La dosis de Midazolam 20 mcg/kg de peso ideal y Fentanilo 2
mcg/kg de peso real logro sedación y analgesia adecuada que permitió la
realización de CPRE en el 26 % de pacientes. La dosis de midazolam en rango de
20 a 30 mcg/kg y fentanilo 2-3 mcg/kg de peso real logro la sedación suficiente
(Ramsay 2, 3, 4,) que permitió la realización de CPRE en el 96-98% de los
pacientes. La dosis de fentanilo en rango de 2 a 3 mcg/kg logro analgesia (EVA 0
– EVA 1) que permitió la realización de CPRE en el 96 % de los pacientes. No se
encontraron complicaciones estadísticamente significativas asociadas a las dosis
de midazolam o fentanilo empleadas en el estudio.
CONCLUSIONES Y SUGERENCIAS: Se sugiere implementar la dosis sugerida
en el estudio: midazolam 20 mcg/kg de peso ideal y fentanilo 2 mcg/kg de peso
real en la realización de CPRE con una duración esperada menor a 45 minutos.
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Sachidanandam, Sivanarulselvan. "Why Physicians Do Or Do not Use Computerized Physician Order Entry Systems: Applying the Technology Acceptance Model." Connect to this title online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1151258487.
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Le, Guenic Sarah. "Dehydration in aqueous media." Thesis, Compiègne, 2015. http://www.theses.fr/2015COMP2238/document.
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Les années 1990 ont été marquées par le développement de la Chimie Verte avec les premiers travaux sur le sujet et l’introduction des Douze Principes. Depuis, le nombre de recherches sur la Chimie Verte n’a cessé de croître. Ces travaux de thèse portent sur le développement de méthodes de déshydratation dans le but de former des molécules à haute valeur ajoutée en utilisant les Douze Principes de la Chimie Verte en tant que ligne directrice. Deux molécules cibles ont été sélectionnées : (i) le phénylacétaldéhyde, obtenu par déshydratation du 1-phényléthane-1,2-diol, qui est utilisé dans la composition de parfums, de médicaments, d’insecticides, etc., ou en tant qu’intermédiaire réactionnel ; et (ii) le furfural, formé par la triple déshydratation du D-xylose (monomère principal des hémicelluloses), qui peut être utilisé comme solvant sélectif ou comme molécule plateforme pour produire une large gamme de composés d’intérêt. Plusieurs points-clés ont été identifiés pour concevoir des procédés de déshydratation verts: le solvant (l’eau ou le solvant éco-compatible CPME), la méthode d’activation (utilisation d’irradiation micro-ondes ou d’un réacteur en flux continu) et le catalyseur (chlorures de métaux ou résine échangeuse d’ions)The 1990s have witnessed the development of Green Chemistry with the first researches on the subject and the introduction of the Twelve Principles. Since then, the number of scientific works on Green Chemistry has continuously grown. This PhD work focus on the development of dehydration methods to form high added value molecules by using the Twelve Principles of Green Chemistry as a guiding framework. Two target molecules were selected: (i) phenylacetaldehyde, obtained by the dehydration 1-phenylethane-1,2-diol, which is used in perfume compositions, for the preparation of pharmaceuticals, insecticides, etc., or as a chemical intermediate; and (ii) furfural, formed thanks to the triple dehydration of D-xylose (the main sugar unit of hemicellulose), which can be used as a selective solvent or as a platform molecule to produce a wide range of high-value chemicals. The optimisation of green production processes was focused on several key points: solvents (water and the eco-friendly CPME), activation method (microwave irradiation and continuous flow) and catalysis (metal chlorides and ion-exchange resin)
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Borges, Wagner Luis. "Uma análise na implantação do CPFR em empresas de varejo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/18/18156/tde-02052012-114021/.
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A gestão da cadeia de suprimentos, suas complexidades e os desafios relacionados à interação entre os elos, que são formados geralmente por empresas de culturas e estruturas diferentes, trazem desafios quanto à interação desses elos. Algumas iniciativas de gestão da cadeia de suprimentos, com conceitos de colaboração são utilizadas, com propósito de oferecer maior interação ao longo da cadeia de suprimentos. Uma dessas iniciativas denominada CPFR, propõe uma concepção colaborativa nas atividades de planejamento, previsão e reposição, e vem sendo adotada entre varejos e fornecedores. Seus resultados, suas vantagens, suas barreiras e os processos para a sua implantação através de uma metodologia adotada pela VICS® são expostos, entretanto, pouco se tem evidenciado nestes trabalhos a relação quanto à maturidade necessária para implantar uma atividade colaborativa na cadeia de suprimentos varejista. A colaboração talvez exija esforços que podem ser constituídos além das questões estruturais de uma organização. Este trabalho tem como objetivo propor uma avaliação destes aspectos colaborativos na implantação do CPFR. Para isso, o tema CPFR e a concepção da colaboração na cadeia de suprimentos foram revisados e foram utilizados multi-casos de uso onde o CPFR foi implantado no varejo brasileiro. Os resultados obtidos por esses estudos de casos apontam maiores dificuldades aos aspectos da colaboração exigidos na implantação do CPFR ou durante ela, do que os aspectos estruturais ou tecnológicos. Assim, o entendimento desses aspectos colaborativos em uso com a metodologia baseada no modelo da VICS® ou qualquer outra empregada, evidencia que o entendimento dos aspectos colaborativos ao implantar o CPFR nas empresas de varejo é um importante apoio ao processo de implantação.The management of the supply chain, its complexities and challenges related to the interaction between the links, which are usually formed by companies from different cultures and structures, bring challenges to the interaction of these links. Some initiatives in supply chain management with collaboration concepts are used, with the purpose of providing greater interaction along the supply chain. One such initiative called CPFR, we propose a design in collaborative planning, forecasting and replenishment, and has been adopted between retailers and suppliers. Their results, its advantages, its processes and barriers to its implementation through a methodology adopted by VICS® are exposed, however, little has been evidenced in these studies the relationship in terms of maturity required to deploy a collaborative activity in the retail supply chain. The collaboration may require efforts that can be made in addition to structural issues within an organization. This work aims to propose a collaborative evaluation of these aspects in the implementation of CPFR. For this, the theme and design CPFR collaboration in the supply chain have been reviewed and were used multi-use cases where CPFR has been deployed in Brazilian retail. The results of these case studies point to the most difficult aspects of collaboration required in the implementation of CPFR or during her than structural or technological aspects. Thus, the understanding of these aspects in use with the collaborative methodology based on the model of VICS® or any other employee, shows that the understanding of the collaborative aspects when deploying CPFR in retail businesses is an important support the deployment process.
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Guéninchault, Nicolas. "Étude expérimentale et numérique des premiers stades de la plasticité dans un polycrystal CFC par topotomographie aux rayons X et CPFEM." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEM026/document.
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La compréhension des mécanismes de déformation dans les matériaux polycristallins est un problème important, qui conditionne notre capacité à concevoir et à produire des pièces de structure plus sures et avec un impact environnemental moindre. Cette compréhension est aujourd'hui limitée par notre capacité à observer à la fois la microstructure du matériau et ses mécanismes de déformation en trois dimensions (3D) aux petites échelles, et à informer les simulations mécaniques à partir des mécanismes physique de déformations du réseau cristallin. Des progrès considérables ont été faits dans les dernières décennies avec les observations de surfaces (i.e. technique EBSD associée a de la corrélation d’image) qui a permis de nombreuses études combinant des observations expérimentales à des simulations, à partir de la surface de la microstructure. Cependant, une comparaison précise sans connaitre la microstructure sous-jacente reste un défi. Dans ce travail, nous proposons une nouvelle méthodologie basée d'une part sur des mesures couplant la tomographie et la diffraction des rayons X, et d'autre part sur des simulations mécaniques de platicité cristalline. Cette approche permet une comparaison quantitative en volume entre les mécanismes de déformation, l’évolution de la courbure du réseau cristallin et les champs mécaniques simulés.Pour ce faire, une machine de traction dédiée aux expériences 4D d’imagerie par diffraction sur grands instruments a été conçue, et utilisée pour déformer en tension un échantillon d’Aluminium Lithium. La cartographie 3D de la microstructure a été obtenue par tomographie par contraste de diffraction, et un agrégat de trois grains dans le volume de l’échantillon a été choisi comme région d’intérêt pour des observation 4D par topotomographie. L’apparition des premières bandes de glissement en volume et leur évolution au cours du chargement ont été observées le long de plans cristallographiques bien définis. Les trois grains ont montré une activité plastique le long de deux familles de plans différents, pas toujours en accord avec une analyse macroscopique du facteur de Schmid, ce qui est attribué à l'influence du voisinage sur l'activation des systèmes de glissement. Les changements d’amplitude et d’orientation de la courbure moyenne des grains ont été mesures avec un niveau de détail sans précédent, par une analyse tridimensionnelle des courbes de reflexions.En parallèle, des simulations de la plasticité cristalline par éléments finis (CPFE) ont été menées utilisant la cartographie tridimensionnelle de la microstructure mesurée expérimentalement. Un chargement uniaxial de traction a été applique pour reproduire numériquement l’expérience, et comparer grain par grain l’activité plastique. L’activité des systèmes de glissement prédite par le modèle est conforme aux observations expérimentales d’une activité plastique le long de deux plans. Un cadre mathématique pour prédire l’angle de Bragg local en fonction des déformations et des rotations du réseau cristallin a été formulé. Un post-traitement des champs intragranulaires de déformation à partir des résultats des simulations CPFE a montré une excellente concordance avec les résultats expérimentaux. Ce résultat confirme que la topotomographie in-situ aux rayons X est un outil prometteur pour l’étude des premiers stades de la plasticité cristalline en volumeUnderstanding the intimate details of plastic deformation in polycrystalline materials is an important issue to improve material design and ultimately produce safer structural parts with less impact on the environment. This understanding is presently limited by our ability to observe both the microstructure of the material and the deformation processes in three dimensions (3D) at small length scales and inform mechanical simulations with physical deformation mechanisms of the crystal lattice. Considerable progress has been made in the last decade with surface observation (eg EBSD coupled to digital image correlation) which led to numerous studies combining experimental observations and simulations from the surface microstructure. However, an accurate comparison without knowing the underlying microstructure remain challenging. In this work, we propose a new methodology which allows a quantitative comparison between the observation of deformation mechanisms, the evolution of the grain lattice curvature and the simulated mechanical fields.For that purpose, a mechanical stress rig dedicated for synchrotron 4D diffraction imaging experiments has been designed, and used to deform an Aluminium-Lithium specimen under tension. The 3D grain map has been obtained by diffraction contrast tomography analysis, and a cluster of three grains within the bulk has been selected to be the region of interest of the 4D observation by X-ray topotomography. The appearance and evolution of 3D crystalline defects as a function of the applied load has been observed to be located along well defined crystallographic planes. All three grains showed plastic activity on along two different set of planes, which is not always coherent with a macroscopic Schmid Factor analysis. The change of the amplitude and the orientation of the average grain curvature has been measured with an unprecedented level of detail by means of 3D rocking curve analysis.In parallel, crystal plasticity finite element (CPFE) simulations have been carried using the 3D grain map measured experimentally. Tension loading was applied to reproduce the experiment numerically and compare the plastic activity on a grain by grain basis. The slip system activity predicted by the model matches in most cases the observed two slip system scenario. A mathematical framework to predict the local Bragg angle based on the stretch and rotation of the crystal lattice by the elastic strain tensor was derived. Post-processing the intragranular strains fields from the CPFE results allowed to simulate 3D rocking curves, showing excellent agreement with the experimental measurements. This result confirms that in situ X-ray topotomography is a promising tool to study the early stage of polycrystal plasticity within the bulk of millimetric material specimens
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Dowell, Simon J. "A functional analysis of yeast CPF1 and comparison with mammalian USF." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303647.
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Rasheed, Bilal. "A novel targeted DNA insertion system using Cpf1 and Himar transposase." Thesis, Rasheed, Bilal (2022) A novel targeted DNA insertion system using Cpf1 and Himar transposase. Honours thesis, Murdoch University, 2022. https://researchrepository.murdoch.edu.au/id/eprint/66118/.
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CRISPR-Cas proteins have been exploited in genome recombineering research since they can induce targeted Double Stranded Breaks (DSBs) in the DNA. This has been particularly useful since cellular repair mechanisms will resect DSBs and introduce mutations in the process. Each Cas protein has a distinct PAM recognition site which expands the range of possible DNA targets in a genome. Catalytically dead versions of CRISPR-Cas enzymes which cannot introduce a DSB but are still able to bind to DNA has facilitated studies in gene repression and regulation. A dead-Cas9 protein has been fused to the Hsmar transposase showing a proof of concept for targeted DNA insertion.
This thesis has developed novel strategies to fuse a catalytically dead dCpf1 protein to the Mariner Himar transposase producing a protein that is able to target T-rich PAM sites for targeted DNA insertion. A strategy was designed to facilitate the cloning of the fusion under the control of the inducible promoter pTet in a p15A chloramphenicol resistant backbone. In this strategy, the final plasmid carrying this fusion was designated pDHD. This construct was designed so that different guides could easily be directionally cloned into the backbone and be transcriptionally activated by T7 RNA polymerase. This feature is particularly desirable as it allows the plasmid to target many different DNA sites.
To monitor for integration into DNA a bioassay was developed. The design included the use of Escherichia coli DH5α (pDHD, pSW213 and pT7T7) grown in the presence of anhydrous tetracycline (aTc) to induce the dCpf1-Himar fusion and IPTG to induce RNA polymerase, the guide RNA for dCpf1 and lacZα. This would enable the chromosomal lacZω to be targeted by dCpf1-Himar fusion complexed to its guide to enable incorporation of the mini-Himar transposon carrying neomycin resistance at this location. This mini-Himar transposon is located within the backbone of pSAM_Rl. Since this plasmid carried an active TnpA, this gene had to be excised by restriction digestion and religated. This gene was excised in this study and the final construct was designated pSAM_RlΔTnpA. Since this plasmid contains an R6K oriV, it would need to be electroporated into E. coli DH5α (pDHD, pSW213 and pT7T7) in order to be replicated. Transformants containing mini-Himar insertions would need to be selected as neomycin resistant white colonies on plates containing neomycin, X-Gal, aTc and IPTG.
All components were prepared for the assay except for pDHD which did not contain the Cas-TnpA fusion as expected based on the restriction profile. Further work is required to ensure the correct restriction profile is established prior to performing the bioassay. An alternative strategy to produce the Cas-TnpA fusion was designed, but due to time constraints, further work is necessary to produce the final construct. Once the final Cas-TnpA construct has been developed, successful targeted transposition could be tested using the bioassay outlined in this thesis.
The development of an inducible dCpf1-Himar transposase fusion would expand the current toolset available to scientists to perform targeted DNA insertions.
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O'Sullivan, Harrison. "CRIPTIC-12a: A novel CRISPR Programmable Transposon Insertion system using Cas12a (Cpf1)." Thesis, O'Sullivan, Harrison (2020) CRIPTIC-12a: A novel CRISPR Programmable Transposon Insertion system using Cas12a (Cpf1). Honours thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/63541/.
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The Acidaminococcus sp. enzyme AsCpf1 has recently been adopted for gene editing purposes since it can be guided to a T-rich PAM recognition site instead of the G-rich PAM recognition site of the widely used SpCas9. Both systems engineer targeted double stranded breaks in DNA that can be repaired by non-homologous end-joining (NHEJ) or homology directed repair (HDR) mechanisms to generate genetic mutations in eukaryotes.
In prokaryotes that lack NHEJ and HDR repair processes, random mutation can be introduced via transposase enzymes that cleave dsDNA and insert transposable elements into these locations. The TnpATn5 protein, native to the prokaryote Escherichia coli, binds to a set of inverted terminal repeats that flank the transposon Tn5, or its derivatives, and excises the element before randomly inserting this transposable element into a gene to create a knock-out mutation.
In this thesis a novel strategy was designed to fuse a catalytically inactive AsdCpf1 endonuclease to TnpATn5-NB/HYP (a modified Escherichia coli Tn5 transposase) to produce the chimeric protein AsdCpf1-TnpATn5-NB/HYP that could be used to produce programmable transposition. Domain and 3D protein analysis were used to theorize the best structural configuration of the fusion between AsdCpf1 and TnpATn5-NB/HYP. The TnpATn5-NB/HYP component was engineered to contain six mutations; four of which were used to make it non-biased, and two of which were used to make the transposase hyperactive.
To ascertain whether the fused protein components were functional, two highly regulated modular bioassays were developed and implemented. A tripartite plasmid bioassay was used to detect repression by AsdCpf1 or AsdCpf1-TnpATn5-NB/HYP, and a quadripartite plasmid bioassay was used to detect non-targeted and targeted insertion events catalyzed by AsdCpf1-TnpATn5-NB/HYP.
The core plasmid system was tripartite and contained compatible oriV elements and distinct antibiotic resistance markers to force for plasmid retention. The first plasmid was engineered to carry the programmable guide production module gCPF1 and the AsdCpf1 or AsdCpf1-TnpATn5-NB/HYP effector modules. The “CHOPCHOP” algorithm predicted guides were cloned into the gCPF1 module at directional BsaI sites. The second plasmid contained the lacIq regulatory component, and either the lacZα (colourimetric detection) or sacB (viability assay) genes required for the repression bioassays. The third plasmid contained a LacIq regulated T7p07 gene, the product of which transcribed the crRNA in the gCPF1 module. This system could be switched from an OFF state to an ON state in the absence or presence of IPTG, respectively. In the ON state, the single copy lacZω sequence on the E. coli chromosome was noticeably repressed by two of the three guides complexed with AsdCpf1. The sacB sequence introduced on a multi-copy plasmid could only be noticeably repressed by one of the guides complexed with AsdCpf1. This thesis showed repression was highly dependent on both guide sequence location and gene copy number. The assay repeated with the chimeric protein revealed that repression was occurring, albeit at a diminished level.
The core AsdCpf1-TnpATn5-NB/HYP system was expanded to a quadripartite bioassay that included a suicidal R6K plasmid delivering a mTn5 transposable element. Using this system in the OFF state, transposition was shown to occur into random sites that excluded lacZω. In contrast, using this system in the ON state, transposition only occurred in the lacZω gene, revealing functional guided transposition could be obtained. The successful creation of the chimeric AsdCpf1-TnpATn5-NB/HYP protein in this thesis provides an essential foundation for further work developing Cas-Tnp fusion proteins for work in prokaryotic hosts. It also provides another step towards large-scale gene silencing and editing with extraordinary accuracy.
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Kent, Nicholas A. "Chromatin modulation in Saccharomyces cerevisiae by Centromere and Promoter Factor 1." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359458.
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Fazal, Mohammed. "Understanding the microstructural efects in a large grain cast nickel-based superalloy." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/understanding-the-microstructural-efects-in-a-large-grain-cast-nickelbased-superalloy(a6255d81-ba70-48ed-a5bc-917ae1e95fb4).html.
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Scatter observed in the fatigue test results of a cast nickel-based superalloy may arise from its coarse grain microstructure. With only a few grains through the sample cross-section, it has been postulated that the inherent anisotropy of individual grains results in the different surface strain distributions during testing. Crystal plasticity finite element modelling (CPFEM) was used to model the deformation of a fat test piece containing a few grains in the cross-section. The mesh was generated using EBSD maps from the surfaces of samples that were subjected to monotonic and cyclic loading at two different temperatures. Digital image correlation (DIC) was used to study the local strain the same sur- faces. Heterogeneous strain distribution, that could be responsible for scatter in the fatigue test results, was observed both in the model and experimentally. However, they were quantitatively different. These differences are attributed to the simplistic microstructural representation in the model and its inability to accurately represent intergranular deformation. The inherent anisotropy within grains resulted in different surface strain distributions during cyclic loading and it was observed that the fatigue life of the test specimens could be correlated to the maximum plastic strain in the sample at the end of the first cycle. As the CPFE model captured the maximum strain measured experimentally, the maximum strain at the end of the first cycle was determined as a fatigue indicator parameter (FIP) for the number of cycles to failure. Randomly generated synthetic microstructures were then loaded in tension and it was observed that when using local strain as a FIP, the scatter in orientations of individual grains resulted in scatter in the expected fatigue life.
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Lenoir, Chloe. "EVALUATING THE VALIDITY AND RELIABILITY OF PSYCHOLOGICAL FLEXIBILITY MEASURES IN CHILDREN AND ADULTS." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/theses/2777.
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The current study evaluated the reliability and validity of psychological flexibility self-report measures between typically developing under 18 and over 18 aged individuals. An independent samples t test with a correlational statistical analysis was conducted to evaluate the relationship between the CPFQ, CAMM, AFQY and AAQII. The results demonstrated that three out of four measures are reliable and valid in determining psychological flexibility between the two groups. This study adds to literature that is conducive in the analysis of measures that are designed for younger population to be utilized by practitioners with older populations reliably.
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Rondinelli, Simone Franco. "A exploração da lambreta, Lucina pectinata (Bivalvia, Mollusca), nos manguezais de Garapuá – Baixo Sul da Bahia, Brasil." reponame:Repositório Institucional da UFBA, 2013. http://www.repositorio.ufba.br/ri/handle/ri/12657.
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Fapesb
Recursos pesqueiros constituem importante fonte de renda e proteína indispensáveis à subsistência de populações tradicionais da zona costeira. Na Vila de Garapuá - BA, a lambreta, Lucina pectinata, é o principal recurso explorado nos manguezais. O presente estudo teve como objetivo testar se em áreas menos exploradas, os indivíduos de L. pectinata teriam maiores densidades e maiores comprimentos, e se houve diminuição entre cpues anuais. Foram realizadas amostragens mensais em dois habitats (canais e quizangas) em seis áreas de manguezal através de quadrados aleatórios. Os resultados indicaram que áreas mais próximas apresentaram densidades significativamente menores do que áreas mais afastadas. As densidades foram significativamente maiores nas quizangas, indicando que os indivíduos são mais facilmente capturados nos canais e/ou que os indivíduos ocorrem naturalmente em maiores densidades nas quizangas. Houve um aumento significativo na cpue mensal de lambreta, de 18,2 (2001) para 19,3 dz./marisqueira/dia (2007), indicando que este estoque parece não estar sendo sobre-explorado. Todavia, as marisqueiras mais antigas relatam uma queda em sua captura diária, uma vez que esta espécie vem sendo explorada comercialmente há mais de 30 anos. Dessa maneira, a diferença de densidade entre áreas próximas e distantes à vila pode ser um efeito da exploração constante ao longo dos anos.
Salvador (BA)
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Carter, Henry M. "Relationship Between Hospital Performance Measures and 30-Day Readmission Rates." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2958.
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Medical errors occur at the prescription step due to lack adequate knowledge of medications by the physician, failure to adhere to policies and procedures, memory lapses, confusion in nomenclature, and illegible handwriting. Unfortunately, these errors can lead to patient readmission within 30 days of dismissal. Hospital leaders lose 0.25% to 1% of Medicare’s annual reimbursement for a patient readmitted within 30 days for the same illness. United States, lawmakers posited the use of health information technology, such as computerized physician order entry scores systems (CPOES), reduced hospital readmission, improved the quality of service, and reduced the cost of healthcare. Grounded in systems theory, the purpose of this correlational study was to examine the relationship between computerized physician order entry scores, medication reconciliation scores, and 30-day readmission rates. Archival data were collected from 117 hospitals in the southeastern region of the United States. Using multiple linear regression to analyze the data, the model as a whole did not significantly predict 30-day hospital readmission rate, F (2, 114) = 1.928, p = .150, R2 = .033. However, medical reconciliation scores provided a slightly higher contribution to the model (β = .173) than CPOES (β = .059. The implications for positive social change included the potential to provide hospital administrators with a better understanding of factors that may relate to 30-day readmission rates. Patients stand to benefit from improved service, decreased cost, and quality of healthcare.
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Eliscovich, Carolina. "Spindle-Localized CPE-Mediated Translation Controls Mediotic Chromosome Segregation." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7123.
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La progresión meiótica y el desarrollo embrionario temprano están programados, en parte, por la activación tradcuccional de mRNAs maternos como lo son los que codifican para las proteinas de ciclina B1 o mos. Estos mRNAs no son traducidos al mismo tiempo ni en el mismo lugar. Por lo contrario, su traducción está especificamente regulada por elementos de poliadenilación citoplasmática (CPEs) presentes en sus 3'UTRs. Los elementos CPEs reclutan a la proteina de unión a CPE (CPE-binding protein CPEB (Colegrove-Otero et al., 2005; de Moor et al., 2005; Mendez and Richter, 2001; Richter, 2007)). Esta proteina de unión al RNA no sólo determina cuándo y en qué medida un mRNA será activado traduccionalmente por poliadenilación citoplasmática (Mendez et al., 2000a; Mendez et al., 2000b; Mendez et al., 2002) sino que también participa, junto con el represor de la traducción Maskin, en el transporte y la localización de sus mRNAs diana hacia los sitios de localización subcelular donde su traducción ocurrirá (Huang et al., 2003; Huang and Richter, 2004). Durante el desarrollo embrionario de Xenopus, CPEB se encuentra localizada en el polo animal de los oocitos y más tarde, sobre el huso mitótico y centrosomas en el embrión (Groisman et al., 2000). Se ha demostrado que embriones de Xenopus inyectados con agentes que interrumpen la traducción dependiente de poliadenilación citoplasmática, detienen la división celular y presentan estructuras mitóticas anormales (Groisman et al., 2000). En este trabajo que derivó en mi tesis doctoral, hemos demostrado que la activación traduccional localizada en el huso mitótico de mRNAs regulados por CPEB que codifican para proteinas con una conocida función en aspectos estructurales del ciclo celular como la formación del huso mitótico y la segregación cromosómica, es esencial para completar la primera división meiótica y para la correcta segregación cromosómica en oocitos de Xenopus.
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Straube, Laurentia. "Import von ESBL und Carbapenemase bildenden Enterobaceriaceae durch Reisende nach Deutschland." Doctoral thesis, Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-223778.
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303 gesunde, deutsche Freiwillige, die in 53 verschiedene Länder (meist nach Asien, Afrika und Südamerika) reisten, wurden in eine prospektive Kohortenstudie aufgenommen. Stuhlproben und Daten über potenzielle reiseassoziierte Risikofaktoren (wie Reisestil, Essgewohnheiten, Auftreten von Gastroenteritis, Hygienemaßnahmen) wurden vor und nach der Reise mittels Fragebogen gesammelt. Mittels Selektivmedien (CHROMagar™ ESBL/KPC-Platten) wurden eine Untersuchung der Stuhlproben auf extended-spectrum beta-lactamase bildende Enterobacteriaceae (ESBL-PE) und Carbapenemase bildende Enterobacteriaceae (CPE) durchgeführt. Isolate mit bestätigtem ESBL-Phänotyp wurden auf das Vorhandensein von blaCTX-M-, blaTEM-, blaSHV-, blaVIM-, blaNDM-, blaKPC- und blaOXA-48-Genen mit Hilfe von PCR-Amplifikation und -Sequenzierung getestet. Bei den Antibiotikaempfindlichkeitstests wurde mit konventioneller Mikrobouillonverdünnung gearbeitet. Die Auswertung von 205 kompletten Teilnahmen zeigte vor Reiseantritt eine ESBL-PE Prävalenzrate von 6,8% (14/205). Unter den 191 Teilnehmern, die vor der Reise ESBL-negativ getestet wurden, waren nach Reiserückkehr 58 (30,4%) mit ESBL-bildenden Escherichia coli kolonisiert und 5 Reisende (8,6%) waren zusätzlich mit ESBL-produzierenden Klebsiella pneumoniae besiedelt. Carbapenem-resistente Enterobacteriaceae wurden nicht nachgewiesen. Die molekulargenetische ESBL-Typisierung zeigte, dass 52/54 (96,6%) der E. coli und 4/4 (100%) der K. pneumoniae-Stämme, die für die Sequenzierung verfügbar waren, CTX-M-Enzyme produzierten, und zwar überwiegend CTX-M-15 (33/56, 58,9%), und 2/54 (3,7%) der E. coli-Stämme SHV-12-Enzyme bildeten. Die Reisenden nach Indien wiesen die höchste Kolonisationsrate mit ESBL-PE (11/15, 73,3%: p=0.015) auf, gefolgt von Reisenden nach Südostasien (22/46, 47,8%; p=0.038). Die Auswertung der reiseassoziierten Risikofaktoren ergab allein für das Auftreten einer Gastroenteritis eine statistische Signifikanz (p=0.011). Strikte Händehygiene und ausschließliches Konsumieren abgepackter Getränke zeigten keinen protektiven Effekt. Die ESBL-PE-Persistenzrate nach 6 Monaten lag bei 8,6% (3/35). Daraus schlossen wir, dass weltweite Anstrengungen notwendig sind, um die weitere Ausbreitung von ESBL-PE in der Bevölkerung anzugehen. Eine aktive Überwachung und Kontaktisolation ist bei Aufnahme in eine medizinische Einrichtung speziell für Patienten, die innerhalb der letzten 6 Monate nach Indien und Südostasien gereist waren, empfehlenswert.
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Nissom, Peter Morin. "A structural and functional analysis of CPF1, a bHLHZIP protein of Saccharomyces cerevisiae." Thesis, University of Oxford, 1998. http://ora.ox.ac.uk/objects/uuid:93828daa-84e6-419b-ac80-1b86108a414f.
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CPF1 (centromere promoter factor 1) of Saccharomyces cerevisiae is a multifunctional protein. This multifunctionality may be associated with the different forms of the protein. To date, no clear function has been attributed to this protein. The general roles currently attributed to CPF1 are: maintenance of proper chromosome segregation or centromere function; methionine prototrophy and chromatin modulation. A series of recent papers have suggested the possibility of CPF1 being involved in protein-protein interactions. This thesis shows that CPF1 has an additional protein-protein interaction domain which is a coiled-coil. A truncation of CPF1 coding for only the C-terminal dimerization motif was cloned into a 17 expression vector and the protein, Dd, was produced in and purified from E. coli. Characterisation of the conformation of the C-terminal dimerization domain of CPF1 show the presence of a leucine zipper in Dd and that Dd forms a dimer under physiological conditions. Sequence alignment analysis of CPF1 and other bHLHZIP proteins identified a conserved serine residue in the basic domain of CPF1 and a conserved asparagine residue in the leucine zipper. Point mutations were introduced separately mutating these residues into either alanine or glutamate. The mutant alleles were cloned into yeast expression vectors. The cloned alleles were used to transform YAG93, a cpf1 deletion strain. Characterisation of the transformants obtained indicate the possibility of CPF1 being involved in the spindle assembly checkpoint control, possibly as a tethering protein. Finally, attempts were made to identify interacting partners of CPF1 and a purification scheme was designed to purify a putative CPF1 complex. Initially, a GST-CPF1 chimera was used to screen radioactively labelled crude yeast extracts for interacting partners of CPF1. This strategy identified five or six potential proteins which might form a multiprotein complex with CPFl. Attempts were then made to purify this putative complex from S. cerevisiae. The partially purified extracts were tested for CDEI activity, indicative of the presence of CPF1 in the samples and. tjhen analysed for protein content. The samples were also tested in a Holiday junction binding assay and in a histone acetyltransferase activity assay. In conclusion, CPF1 is a bHLHZIP protein that has a role in nutrient signalling and checkpoint control, possibly by acting as an intermediary protein that recruits essential factors to gene promoters or the centromere by protein-protein interactions.
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COURI, VICTOR BARROS. "ANALYSIS AND PERSPECTIVES FROM EMPIRICAL STUDIES IN COLLABORATIVE PLANNING, FORECASTING AND REPLENISHMENT (CPFR)." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2017. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31966@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
A prática do Planejamento, Previsão e Reabastecimento Colaborativo (em inglês, Collaborative Planning, Forecasting and Replenishment – CPFR) é um tema recente de integração de cadeias de suprimento que tem sido amplamente abordado na literatura acadêmica. O CPFR é considerado, para muitos pesquisadores, uma iniciativa mais completa e avançada que outros métodos de colaboração na cadeia, sendo, em alguns casos, uma extensão ou aprimoramento dos mesmos. O amadurecimento do tema é representado pela existência de revisões sistemáticas na literatura. Contudo, por ser o CPFR ainda um tema recente com acentuado crescimento de estudos na literatura, esta dissertação tem como objetivo realizar uma atualização destas revisões sistemáticas para verificar novos avanços no assunto, se lacunas ressaltadas já foram pelo menos parcialmente endereçadas e se tendências estão se consolidando. Mais ainda, em função da dificuldade de se implementar o CPFR na prática, um enfoque maior na análise dos estudos empíricos existentes com o objetivo de ir além de resultados parciais e particulares oferecidos na literatura é contemplado nesta dissertação, expandindo assim o escopo das revisões existentes com o foco específico em estudos empíricos. A dissertação apresenta seus resultados guiados em um framework de síntese para integração de cadeias focado em CPFR, tendo como base os passos para a condução de uma pesquisa empírica em gerência de operações, os blocos conceituais do CPFR e a contribuição dos estudos empíricos. Uma agenda para pesquisas futuras finaliza a dissertação.
The practice of Collaborative Planning, Forecasting and Replenishment (CPFR) is a recent topic of supply chain integration that has been extensively covered in academic literature. The CPFR is considered by several researchers a more complete and advanced initiative than other methods of collaboration in the chain, being in some cases an extension or improvement of them. The maturation of the theme is represented by the existence of systematic reviews in the literature. However, since CPFR is still a recent topic with a strong growth of studies in the literature, this dissertation aims to carry out an update of these systematic reviews in order to verify new advances in the subject, if highlighted gaps have been at least partially addressed, and also if trends have been consolidating. Moreover, due to the difficulty of implementing CPFR in practice, a greater focus on the analysis of existing empirical studies with the objective of going beyond partial and particular results offered in the literature is contemplated in this dissertation, thus expanding the scope of the existing reviews with specific focus on empirical studies. The dissertation presents its results guided by a synthesis framework for supply chain integration focused on CPFR, based on the steps for conducting an empirical research in operations management, the conceptual building blocks for CPFR and the contribution of the empirical studies. An agenda for future research concludes the dissertation.
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Hoffstatter, John Arthur. "Preconceived Physician Attitude Toward Computerized Physician Order Entry (CPOE): Implications for Successful Implementation." UNF Digital Commons, 2004. http://digitalcommons.unf.edu/etd/240.
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There has been a societal and legislative push to implement computerized physician order entry (CPOE) systems throughout hospitals nationally in recent years due in large part to the public's awareness of an inordinate number of patient deaths due to medication errors in hospital settings. This mortality, and untold morbidity, became even more unacceptable when published findings suggested the majority of these 100,000 deaths each year could be avoided through the use of CPOE systems.
Yet acceptance has been slow and only a fraction of the hospitals have implemented this technology due to large start up costs, enormous technological requirements, and prior well-published failures of such attempts largely due to physicians' lack of acceptance.
A total of71 participants were surveyed whose daily responsibility involved the ordering of medications, to determine what attitudes they had concerning CPOE systems. This was done at a facility scheduled to implement such a system over the next year. The data showed evidence supporting many of the current implementation strategies, while suggesting modification of others.
Based on these findings, recommendations are made for future implementations with the hope of gaining enhanced physician acceptance and adoption, facilitating a more successful implementation of CPOE systems.
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Ritter, Fernando Gomes. "Proposta para implementação de CPFR em empresa produtora de adesivos e seus clientes." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2003. http://hdl.handle.net/10183/2410.
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Planejamento, Previsão e Suprimento Integrado (Collaborative Planning Forecasting and Replenisement- CPFR)é um tema que está evoluindo a nível mundial, onde aplicaçõespráticastêm indicadopotencialparapromovera economiae a melhoriano nível de serviço das empresas. O CPFR une a demanda final de produtos com a cadeia produtiva dos mesmos, criando, assim, um processo único em que todos os envolvidos são beneficiados através de relações colaborativas de parceria. A pesquisa apresenta uma revisão teórica sobre o tema, abordando os níveis de colaboração possíveis entre empresas, exemplos de aplicação do CPFR e os resultados obtidos, as diretrizes de implementação com ênfase nos nove passos propostos pela VICS (The Voluntary Interindustry Commerce Standards), os habilitadores necessários para implementação, as etapas envolvidas no desenvolvimento de um projeto piloto e as barreiras para uma implementação. Um estudo de caso é apresentado com uma proposta de aplicação da metodologia CPFR efetuada por uma empresa ligada à produção de insumos para um varejista atuante no mercado moveleiro, onde são destacados os indicadores críticos de performance do processo CPFR. As conclusões obtidas referem-se à aplicabilidade do modelo sugerido pela VICS no Brasil, para a obtenção de resultados semelhantes aos atingidos pelas empresas que já estão utilizando CPFR em seus processos colaborativos de relacionamento.
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Pereira, Julia Myriam de Almeida. "A atividade pesqueira na represa do Lobo-Broa (Itirapina, Brotas-SP): caracterização e composição da captura." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/18/18139/tde-15012006-113300/.
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Em 2002 a produção total de pescado no mundo foi de 133,0 milhões de toneladas. No Brasil, o volume total desembarcado foi de 822,2 mil toneladas, sendo cerca de 26,5% provenientes da pesca em água doce. A represa do Lobo-Broa (Itirapina, Brotas, SP; 22°15S, 47°49W) pode ter a sustentabilidade de seus recursos pesqueiros comprometida devido à proximidade de cidades como São Carlos e Itirapina. O objetivo geral deste trabalho foi estudar as pescarias esportivas e suas artes, realizar pescarias experimentais e estudar as composições das capturas de ambas pescarias. O trabalho foi apresentado em oito capítulos: (1) apresentação, (2) caracterização sócio-econômica dos pescadores esportivos, (3) descrição das capturas das pescarias esportivas, (4) descrição das capturas das pescarias experimentais, (5) análises estatísticas sobre as ambas, (6) estudo preliminar da seletividade das redes de emalhar utilizadas nas pescarias experimentais, (7) manejo de recursos pesqueiros em reservatórios e (8) considerações finais e recomendações. Entre setembro e novembro de 2004 foram aplicados 38 questionários para avaliação sócio-econômica dos pescadores esportivos e estes indicaram que as pescarias são praticadas principalmente por homens cujo padrão de vida se assemelha à média populacional do país. Entre setembro de 2002 a setembro de 2004 foram realizadas 1027 entrevistas sobre as capturas nos três principais locais de pescarias esportivas (praia, píer e horto florestal). As pescarias esportivas são praticadas com vara de pescar simples e com molinete, principalmente no horto florestal, local que apresentou maiores as cpues e onde foi registrado o maior esforço pesqueiro. A captura foi composta de Ciclídeos (cará, Geophagus brasiliensis, tilápia do Nilo, Oreochromis niloticus, tilápia do Congo, Tilapia rendalli e tucunaré Cichla monoculus), principalmente, embora a represa não tenha elevada produtividade pesqueira. A sazonalidade e o uso de isca/ceva não se mostraram estatisticamente significativos. Para avaliação da composição da ictiofauna da represa, foram realizadas sete pescarias experimentais entre novembro de 2002 e setembro de 2004 em três locais (horto/Itaqueri, meio e barragem), utilizando redes de emalhar. As espécies que tiveram maiores capturas relativas foram o cará e o lambari rabo amarelo (Astyanax altiparanae) e a região com maiores capturas relativas foi o horto/Itaqueri. A sazonalidade e a variação diuturna não foram significativas estatisticamente. Buscou-se detectar os fatores e a covariável estatisticamente significativos (P<0,05) sobre as capturas dos estudos acima, testando-se dois modelos de análise de covariância com três fatores (3 way ANCOVA). O estudo da seletividade das redes de emalhar para cada espécie por abertura de malha mostrou que as redes foram seletivas para os lambaris rabo amarelo e rabo vermelho (Astyanax scabripinnis paranae), sagüiru (Cyphocharax modesta) e cará. Para tuvira (Gymnotus carapo), cascudo (Hypostomus sp) e mandi (Pimelodella cf gracilis) esta arte não foi seletiva. Com base nos estudos acima, concluiu-se que as pescarias esportivas deveriam ser incentivadas visando o aumento do turismo na região e da produtividade pesqueira da represa. Porém, faz-se urgente a conscientização para que a ceva para os peixes deixe de ser utilizada, pois esta prática não aumenta as capturas e contribui para o processo de eutrofização represaIn 2002 the total production of fish in the world was 133,0 million tons. In Brazil, the total volume of fish was of 822,2 thousand tons, with 26,5% coming from freshwater fisheries. The Lobo-Broa reservoir (Itirapina, Brotas, SP; 22°15'S, 47°49'W), can have the sustainability of their fishing resources changed due to the proximity of cities as São Carlos and Itirapina. The general objective of this work was to study the sporting fisheries and their fishing gears, to do experimental fisheries and to study the compositions of the captures of both studies. The work was presented in eight chapters: (1) presentation, (2) socioeconomic characterization of the sporting fishermen, (3) description of the captures of the sporting fisheries, (4) description of the captures of the experimental fisheries, (5) statistical analyses on the both fisheries, (6) preliminary survey of the selectivity of the gillnets used in the experimental fisheries, (7) handling of fishing resources in reservoirs and (8) final considerations and recommendations. Among September and November of 2004 it was applied 38 questionnaires for socioeconomic evaluation of the sporting fishermen and these indicated that the fisheries are practiced mainly by men whose standard of living resembles each other to the population average of the country. Among September of 2002 to September of 2004, 1027 interviews were did on the captures in the three main places of sporting fisheries (praia, píer and horto florestal). The sporting fisheries are practiced with simple fishing rod and with reel, mainly in horto florestal, place that presented larger captures and where was concentrated the largest fishing effort. The capture is composed of Ciclídeos (cará, Geophagus brasiliensis, tilápia do Nilo, Oreochromis niloticus, tilápia do Congo, Tilapia rendalli and tucunaré Cichla monoculus), mainly, although the reservoir has not elevated fishing productivity. The seasonal variation and the bait use were not shown statistically significant. For fish fauna composition evaluation of the reservoir, seven experimental fisheries were accomplished between November of 2002 and September of 2004 in three places (horto/Itaqueri, meio and barragem), using gillnets. The species that had larger relative captures were the cará and the lambari rabo amarelo (Astyanax altiparanae) and the area with larger relative captures was the horto/Itaqueri. The seasonal variation and the daytime-nighttime variation were not statistically significant. It was detected the factors and the covariates statistically significant (P<0,05) on the captures of the studies above, being tested two models of analysis of covariance with three factors (3 way ANCOVA). The selectivity of the gillnets study for each species, for mesh size showed that the nets were selective for the lambari rabo amarelo, lambari rabo vermelho (Astyanax scabripinnis paranae), sagüiru (Cyphocharax modesta) and cará. For species as tuvira (Gymnotus carapo), cascudo (Hypostomus sp) and mandi (Pimelodella cf gracilis) this fishing gear was not selective. It was believed that the sporting fisheries should be motivated aiming the increment of the tourism in the area and increase of the fishing productivity of the reservoir. A larger understanding of the fishermen is urgent so that the bait stop being used, once this practice doesn't increase the captures and contributed to the eutrofication process in the reservoir
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Spadoni, Alberto. "Confronto tra tecniche di clearance plasmatica nella sepsi." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3524/.
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Brunk, Katja H. "Essays on consumer perceived ethicality (CPE) of companies and brands." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210027.
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Following the call for further research on the consumer perspective of corporate ethics, this research sets out to explore and conceptualize the construct of ‘Consumer Perceived Ethicality’ (CPE), referring to consumers’ aggregate and valenced perceptions of a subject’s(i.e. a company, brand, product, or service) ethicality. Results present novel insights into how positive/negative CPE is formed and impacted by various kinds of corporate conduct, thereby offering some explanations as to why some companies benefit from positive while others suffer from negative moral equity.
Doctorat en Sciences économiques et de gestion
info:eu-repo/semantics/nonPublished
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Hack, Beate. "Evaluierung der CPF-Technologie hinsichtlich der Mikroverkapselung von leichtflüchtigen Substanzen." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/633094/633094.pdf.
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Paccola, José Angelo. "Tarifas horosazonais no Brasil = perspectivas de inovações metodológicas e estudo de caso na CPFL." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263075.
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Orientadores: Sergio Valdir Bajay, Gilberto De Martino JannuzziDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica
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Resumo: Durante as últimas décadas, têm-se introduzido poucas modificações no setor elétrico brasileiro no que se refere às novas modalidades de tarifas para os consumidores finais. As mudanças mais radicais foram implantadas no início da década de oitenta com a introdução das tarifas horosazonais verde e azul. O objetivo desta dissertação é testar as possibilidades de se formular novas tarifas horosazonais no País, através de uma análise crítica da aplicação destas no Brasil e no mundo, e a realização de um estudo de caso envolvendo pesquisas de campo, entrevistas e medições em consumidores industriais atendidos na categoria tarifária A4. A análise da experiência nacional aborda a implantação e o desenvolvimento das tarifas horosazonais - verde, azul e amarela - e tarifas de fornecimento interruptível no País por meio de um histórico completo dos fatos mais importantes, ocorridos desde 1957 até 2006, e de uma avaliação dos resultados a que se chegou com a implantação destas tarifas. Na análise da experiência internacional, examinaram-se os casos de França, Canadá, Estados Unidos e Portugal. O estudo de caso envolveu três pesquisas de campo. A primeira delas teve como objetivo escolher os segmentos industriais com maior potencial para a modulação de carga. Com a segunda pesquisa, conseguiu-se conhecer melhor os consumidores dos segmentos de calçados e de móveis, em termos de perfil de demanda e de detalhes de seus processos produtivos, visando estabelecer, com mais segurança, suas possibilidades de modulação de carga. A terceira pesquisa de campo permitiu o levantamento dos dados técnicos e econômicos, necessários para se fazer simulações e uma avaliação quantitativa dos impactos econômicos decorrentes de um terceiro posto tarifário para estes consumidores, na madrugada. As análises custo/benefício, realizadas no estudo de caso, levaram em conta tanto a ótica do consumidor como a da concessionária. Os resultados das simulações realizadas mostraram que os custos com mão-de-obra chegam a ser 35 vezes maiores do que aqueles com a fatura de eletricidade nestes segmentos industriais. Isto desestimula um possível deslocamento de parte da produção para o período noturno, por conta do adicional noturno no custo da mão-de-obra, mesmo com tarifas de energia elétrica muito baixas neste período
Abstract: During the last decades, the Brazilian electric sector has introduced little changes in tariffs for end-use consumers. The most radical changes were implanted at the beginning of the eighties, with the introduction of a seasonal tariff structure called green and blue. The objective of this work is to test some possibilities to formulate a new seasonal tariff in Brazil, through a critical analysis of these tariffs in Brazil and in other countries. This was made through field researches, interviews and the measuring of some industrial consumers. The national experience analysis includes the implementation and development of the seasonal tariffs - green, blue and yellow -, the supply curtailable rate and a complete historical of the more important facts occurred since 1957 up to 2006, together with an evaluation of the impacts in the implementation of these tariffs. In the analysis of the international experience, it was examined tariffs in France, Canada, United States and Portugal. The case study involved three researches on the field. The first one was to choose the industrial segments with larger potential for load modulation. The second research explored both footwear and furniture industries in terms of theirs demand profile and productive processes, with the objective of establishing their load modulation change possibilities more accurately. The third field research obtained the necessary technical and economical data, to work with simulations in a quantitative analysis of the economic impacts of a third tariff position during night time. The cost-benefit analysis considered both consumers and Utility's point of views. The results of the simulations has shown that the cost of labor is sometimes 35 times higher than electricity bills in the footwear and furniture industries, rendering useless a possible load modulation change during the night. Furthermore, during night time the cost of labor increases
Mestrado
Planejamento de Sistemas Energeticos
Mestre em Planejamento de Sistemas Energéticos
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McIntyre, Christopher. "CPFD Modeling of a Novel Internally Circulating Bubbling Fluidized Bed for Chemical Looping Combustion." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42054.
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Pressurized chemical looping combustion (PCLC) is a promising next generation carbon capture technology which operates on the fundamentals of oxyfuel combustion to concentrate carbon dioxide in the flue gas stream. Oxygen is supplied through cyclic oxidation and reduction of a solid metal oxide between an air reactor and fuel reactor to prevent the direct contact of fuel and air. CanmetENERGY-Ottawa, in collaboration with Hatch Ltd., is designing a pilot scale PCLC system which uses ilmenite as the oxygen carrier and a novel fluidized bed design called the Plug Flow Internally-recirculating Reactor (PFIR). The PFIR consists of an annular bubbling fluidized region in which particles are circulated by angle jets through two reactive zones separated by baffles. The overall objective of this thesis was to provide key design parameters and insight for the construction of the pilot facility.
Experimental work was first conducted investigating the minimum fluidization velocity (Umf), gas bubble size, and tube-to-bed heat transfer coefficients of different ilmenite particle size distributions (PSDs) at varying pressures up to 2000 kPa. The data was compared to a variety of literature correlations. The Saxena & Vogel (1977) constants for the Wen-Yu type correlations (Remf=√C12+C2Ar-C1) resulted in the best fit for predicting the Umf of the PSDs with Sauter mean diameters (SMD) less than 109 μm, while the Chitester et al. (1984) constants resulted in better predictions for the larger particle size distributions (SMD greater than 236 μm). Gas bubble size was found to be marginally impacted by pressure, with the Mori & Wen (1975) correlation best fitting the data. The heat transfer coefficient was found to also be marginally increased by pressure with the the Molerus et al. (1995) correlation matching the atmospheric data. A computational particle fluid dynamic (CPFD) model of the experimental unit was then created and validated using the obtained data for minimum fluidization velocity and bubble size. The accuracy of the model was found to be dependent on the particle close packing factor input variable, with a value of 0.58 resulting in the best results for each of the ilmenite PSDs modeled. Finally, a CPFD model was created for a cold flow design of the PFIR to investigate the impacts of different operating parameters on the solids circulation rate and gas infiltration rate between the two reactor zones. This model used the validated parameters of the previous CPFD model to add confidence to the results. The impacts of increasing superficial gas velocity, fluidizing gas jet velocity, bed height, and pressure were all found to increase the solids circulation rate through their respective impacts on the momentum rate of the fluidizing gas. A polynomial function was fit between these two variables resulting in a method to predict the solids circulation rate. Similarly, the rate of gas infiltration between sections was found to be dependent on the solids circulation rate, allowing for a function to be made to predict the gas infiltration at different operating conditions.
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Tariq, Javid, and Sohail Sajid. "Robust Home Care Access Network." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2616.
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Critical networks e.g. telecare services, telemonitoring, are implemented to provide the information security and reliability that the end user desires, especially during an emergency. Unlike business carrier systems that are planned for the general public’s use, critical communication systems are designed particularly for public protection and other serious communication situations. Availability and reliability of such networks is highly desirable. The following thesis works to compare and analyze a variety of communication access technologies to find out the best primary means of data transportation for health critical services and model reliable communication link by using redundancy. This study also provides an efficient failover mechanism to implement redundant links. This strategy is intended to provide the reliable communication and to protect the established communication link.
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Honniball, Peter Daniel. "The influence of temperature upon the deformation of alpha zirconium." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-influence-of-temperature-upon-the-deformation-of-alpha-zirconium(ea5d6180-0730-492f-89ab-04c6938398f1).html.
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Zirconium is used inside nuclear reactors as fuel cladding. The in-reactor performance of zirconium alloys is strongly influenced by the properties that develop during thermo-mechanical processing, such as the microstructure and crystallographic texture. Optimising the combination of properties would enable improved reactor efficiency, longer component lifetimes and reductions in nuclear waste. Achieving the desired texture and microstructure requires a mechanistic understanding of the processes that govern them: deformation and recrystallisation. These mechanisms are influenced by numerous variables including temperature, strain-rate, and the initial state of the material. This work aims to clarify how texture develops as a result of the active deformation mechanisms of slip and twinning and how these mechanisms are influenced by temperature. The alloy chosen for this is Zircaloy-4.This work has shown that texture evolution varies with deformation temperature. The activation of {10-12}<10-11> tensile twinning dramatically alters the texture up to at least 300°C. In the absence of much twinning at 500°C prismatic slip appears to govern the texture evolution up to moderately high strain. Prismatic slip is generally considered the easiest slip system in zirconium. This work highlights its distinct effect upon both texture and microstructure evolution. In particular the extent of grain fragmentation by prismatic slip is shown to depend upon the initial grain orientation. As a result the break-up of the microstructure takes place heterogeneously. This then has implications for the microstructure and texture development during subsequent recrystallisation treatments. Experimental data indicates that the slip anisotropy between
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Wu, Sung-hua, and 吳松樺. "Synthesis of [CpFe(CO)]4-C60 Complexes by Prato Reaction." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13667968936994327618.
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Niccolai, Gerald Peter. "I. Fenske-Hall molecular orbital studies of [CpM(CO)n]₂ complexes the interplay of metal-metal bonding and bridging and semibridging ligands : II. The photolytic dehydrogenation of the diiron alkylidene complex, [CpFe(CO)]₂([mu]-CO)([mu]-CHCH₂CH₂CH₂CH₃) /." 1992. http://catalog.hathitrust.org/api/volumes/oclc/31370805.html.
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陳志強. "The replenishment model of CPFR." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/q68hxa.
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碩士國立政治大學
資訊管理研究所
96
CPFR (Collaborative Planning, Forecasting, and Replenishment) is one of the applications of collaborative business. The stressed concept is the cooperation process of sellers and buyers on the supply chain in order to increase the handling efficiency. In the future, the industries would compete on the whole supply chains behind products—only the industry that is capable of making accurate predictions according to the constantly changing market and reacts immediately has the chance of winning. Being able to control the inventory and supply effectively would be one of the key factors leading to an industry’s success. The replenishment model of CPFR is to fill out the order according to the sales prediction, order prediction, inventory strategy, and supply information. The precision of the replenishment model could affect both suppliers and customers. The former can distribute products properly and meet the different demands from the upcoming orders so as to reduce inventory; the latter are able to revise the inventory strategy and amount of order according to the order prediction. A few research papers aimed at the replenishment model, though, most still focus on the management issues like the process framework of CPFR and the implementation benefit. Hence, establishing both an information system that coordinates customer demand with suppliers and a collaborative replenishment model that increases the accuracy of predictions is fairly important. The phase of replenishment, as the subject of this study, will approach on parameters the collaborative replenishment model needs to input and combine evolution strategies with tabu search to establish a replenishment model under the process of CPFR.
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Lai, Chih-Wei, and 賴志偉. "Process Modeling for CPFR System." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/7eya76.
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碩士國立臺北科技大學
機電整合研究所
95
In the competitive environment of global supply chain at this present, in order to satisfy more and more demands and expectations from customers, enterprises face many pressures such as cost reduction, short lead-time, quality promotion, and global operation management…etc. But enterprises can’t resolve this pressure by their own; instead, it shall be achieved by the collaboration and integration of overall business entities of supply chain based on the same targets. The VICS committee has published the standards for Collaborative Planning, Forecasting and Replenishment (CPFR), and CPFR has the revolutionary influence on supply chain. However, according to the relevant research and investigation, the applications of CPFR in Taiwan are not prevalent yet currently. Most of enterprises still have the issue of forecast and replenishment with their business entities, and can not reduce cost and shorten lead time effectively. The major cause is enterprises haven’t implemented a CPFR system to link and coordinate overall business entities of supply chain. According to this, this research are based on the enterprise’s demands on CPFR system and literatures review, and use seven-stages development methodology which are including define objectives, process modeling, data modeling, apply business rules, UI interface design, coding and testing. Then focus on the key stages of define objectives and process modeling, and provide a collaborative process modeling that is suitable for overall business entities of supply chain (including four organizations: global operation, subsidiary, factory and buyer). Hopefully, the process modeling will help who are planning to implement a CPFR system. Besides, in order to promote the service capability of orders with multiple deliveries, the process modeling in this research integrate the technology of real-time CTP to shorten lead time and reduce cost based on the well operation of capacity and inventory.
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Tinková, Veronika. "Stanovení aminoanthrachinonu na CPE." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-380581.
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Chen, Chang Chih, and 陳長志. "Construct the Key Operation Mechanism in CPFR." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/84714044556412567231.
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碩士國立高雄應用科技大學
工業工程與管理系碩士班
93
VICS association proposed the Collaborative Planning, Forecasting and Replenishment (CPFR ) model in 1998, it is one of the latest and important ways in the supply chain collaboration management field. Through the nine steps of the CPFR that will lead the forecasting in the collaborative supply chain to be more promissory, and let the replenishment be more efficient. In order to let CPFR be carried out smoothly, this research set the development cycle of the Key performance index, develops the information sharing mechanism of the across organization, and constructs collaborative management by exception mechanism model. Through the three core operation mechanisms constructed in this research that can help enterprises when inject into CPFR to be depend on operation procedure followed, in order to let enterprises succeed while carrying out the CPFR. A shaft bearing company is considered as case study, through the case company to verify the three core operation mechanisms in CPFR which constructed in this research are able to be carried out. Besides, this research can provide the case company to understand the implementation structure and procedure of the whole CPFR even more. At the same time , according to the detail operation procedure of three core operation mechanisms which constructed in this research could to remedy and strengthen stipulating in KPI of case company, could help the case company to choice the information sharing partners in the supply chain and remedy the deficiency of the handling exception mechanism. In general, the three core operation mechanisms lead the case company to execute the CPFR going smoothly, and make it obtain success.
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張怡筠. "Key Factors of Rolling Forecast on CPFR." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02021556096823071648.
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Yang, Cheng-Wei, and 楊政威. "CPFR Chain Process in Multi-Channel Retailing." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/98649757369068642692.
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碩士明志科技大學
工程管理研究所
93
The enterprises are facing globe competition due to the development of information technology and internet. There are two directions for enterprises to keep the competition. For company operation, the enterprises focus on product quality, cost, and operation improvement. For market side, the enterprises try to expend marketing channel and collaboration with other company in order to growth up market share. The Supply Chain Management (SCM) is more and more important for company operation. The CPFR (VICS, 1998) are widely discussion in Supply Chain Management. The CPFR significant improve the sales forecast and reduce the stock have been proved in many cases. When the enterprises expend the marketing channel, it will have different lead time, quantity of lots, operation types by different customer and channels. The enterprises usually have low profit because of high stock for uncertain environment. As the previous research, this research is discussing the CPFR help to improve the sales forecasts and stock when the company expends new channels. In this research, it is a case study for a company which possesses multi-channel and operation process. The study develops a sales forecast model base on CPFR model. Result suggests that this sales model improves sales forecast. Besides, if the CPFR are used in whole supply chain members, the supply chain has become to CPFR Chain, and will improve the sales forecast and reduce the stock of whole supply chain. This cases study can be a reference for further research.
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Lin, Shih-Wen, and 林仕文. "Automating CPFR''s replenishment mechanism with BPEL4WS." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/96766301657306252211.
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碩士國立臺北大學
資訊管理研究所
91
The popular supply chain management solution — Collaborative Planning, Forcasting, and Replenshment (CPFR) has been provided by many vendors. However, the current CPFR solutions are usually an ad hoc approach in nature by utilizing middleware to connect disparate ERP systems. These solutions neither employ a unified descriptive framework to facilitate portability and understanding, nor did the solution is amenable to popular information infrastructure. To amend the insufficiencies of current solutions, we use a popular business process modeling language — BPEL4WS to model the CPFR. We have successfully build the prototype using BPEL4WS to demonstrate the feasibililties.
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Yan-Liang, Liu, and 劉延良. "Performance Analysis of Store-level CPFR Implementation." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/49236995988362206966.
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碩士南台科技大學
企業管理系
97
In a multi-class supply chain structure, all levels become less attracted by the market reaction because of the information inconsistency between the upper and lower levels. This situation often makes the increasing of inventory and not only expend a lot of costs but also affects the acquisition of profits. CPFR is a collaborative planning, forecasting and replenishment systems, and it mainly promote the trading partner relationship between retailer and supplier by sharing information. CPFR also create an environment that meets the need of consumers by providing an operating flow that integrates both side of supply and demand. This study focuses on store-level CPFR which means individual retailer coordinates with supplier. The researcher established three different CPFR operation and simulation models to analyze the CPFR performance under different models and the effect of various factors. This helps companies to choose the most suitable CPFR model for them when trying to practice it. The factors mentioned above include demand type, inventory policies, lead time and the producing capacity of supplier. With the experimental design of this study, the data collected by simulation was analyzed by ANOVA. The result revealed that there were significant differences between three workflows. Model A is non-CPRF which shows the lowest inventory costs and shortage cost but the highest total system cost, so it makes the worst performance on supply chain. The more influential factors of model A are demand type, lead time and the producing capacity of supplier. Model B is a DC-level CPFR which shows the highest inventory cost and the second highest total system cost, so it makes the second best performance on supply chain. Model C is a store-level CPFR which shows the lowest ordering cost and total system cost, so it makes the best performance on supply chain among the three operating flows. The more influential factors of model B and model C are demand type and the producing capacity of supplier. Keyword: Store-level CPFR、Simulation、CPFR
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Tsao, Hui-hua, and 曹慧華. "CPFR CASE STUDY FOR CONTACT IMAGE SENSOR." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/88196914922423770769.
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碩士東吳大學
企業管理學系
97
In the fast-changing industry enviroment, enterprises have paid a lot of money to invest new technology and new market to gain their own competition advantage. But the new technology progressing and material cost rasing make enterprises faced more difficult business competition. Therefore, the various strategic alliance and cooperation are established. This research is to make the in-depth case analysis for three MFP makers how to cooperate with CIS suppliers and enhance their operational agility by CPFR (Collaborative Planning, Forecasting,and Replenishment ) with information sharing。 We can investigate and survey their individual cooperating result. Usually, the data of order forecasting exists uncertainly and vagueness which forced CIS suppliers to adjust their productin plan to catch the tight delivery, and the replenishment system of JIT and VMI caused the high inventory and low material cycling rate. Therefore, Rolling Forecasting has become a well-known and criticial solution. The research reveals some valuable sugestions are the best model of the order forecasting is to implement“VMI + Rolling Forecasting” system. It is helpful to decrease the high inventory & transportation cost to improve the supply chain performace. This model also can be a reference case for other industries.