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1
Dyson, Paul J., and Gábor Laurenczy. "Determination of the Viscosity of the Ionic Liquids [bmim][PF6] and [bmim][TF2N] Under High CO2 Gas Pressure Using Sapphire NMR Tubes." Zeitschrift für Naturforschung B 63, no. 6 (June 1, 2008): 681–84. http://dx.doi.org/10.1515/znb-2008-0614.
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The viscosities of the ionic liquids [bmim][PF6] and [bmim][TF2N] (bmim = 1-methyl-3- butylimidazolium, TF2N = bis(trifluoromethylsulfonyl)imide) have been determined under CO2 pressure at 298 K. The viscosity decreases from 381 to 23 cP for [bmim][PF6] without CO2 and for 2.17 molal CO2 solutions (mole fraction XCO₂ = 0.381, 55 bar CO2), respectively. For [bmim][TF2N] the viscosity decreases from 54 cP for the ionic liquid to 21 cP for a 1.61 molal solution of CO2 (mole fraction XCO₂ = 0.403, 55 bar CO2).
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Wheeler, Kaylee E., Terry J. Klopfenstein, James C. MacDonald, Andrea K. Watson, and Hannah C. Wilson. "55 Rumen undegradable protein content of native range and sub irrigated meadow forages." Journal of Animal Science 98, Supplement_3 (November 2, 2020): 151–52. http://dx.doi.org/10.1093/jas/skaa054.267.
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Abstract The in situ mobile bag procedure was used to compare rumen undegradable protein (RUP) content and RUP digestibility of Nebraska Sandhills range and meadow diet samples. Meadow samples (n = 12) were from June, July and August of 2 years while range samples (n = 19) were from June, July, September and December of 6 years. Samples were collected using esophageally fistulated cows (samples from 2 cows composited per time point), freeze-dried, and ground through a 2 mm screen. For each sample, 1.25 g was weighed into 8 replicate 8×10 cm Dacron bags with 50-µm pore size. Rumen incubation time was based on estimated digestibility and passage rate. Following rumen incubation, analysis of neutral detergent insoluble N (NDIN) on one-half of the bags was used to calculate RUP content. Remaining bags were treated with pepsin/HCl solution (37 °C) and stirred for three hours before duodenal incubation. Analysis of NDIN after recovery from feces determined RUP digestibility. Data were analyzed using month as a fixed effect and year and experiment as random effects. In meadow samples, CP (15.0% of DM) was consistent across June, July, and August (P = 0.72). Range samples tended to differ in CP content (P = 0.11), with June, July and September being similar (8.15% of DM) while December was 6.01%. In meadow samples, RUP averaged 21.9% of CP while range samples averaged 26.7% of CP, with no differences due to month (P ≥ 0.32). Because CP content was changing in range samples, RUP as a % of DM tended (P = 0.14) to decrease in December (1.66) compared to June, July, and Sept (2.25). In meadow samples, RUP digestibility (%) declined from 74.7% in June to 61.4% in July and Aug (P = 0.07). RUP digestibility (%) averaged 43.9% for all range samples (P = 0.66).
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Lius, S., R. Manshardt, D. Gonsalves, M. Fitch, J. Slightom, and J. Sanford. "364 FIELD TEST OF VIRUS RESISTANCE IN TRANSGENIC PAPAYAS." HortScience 29, no. 5 (May 1994): 483b—483. http://dx.doi.org/10.21273/hortsci.29.5.483b.
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Twenty transgenic Carica papaya plants ('Sunset', Roclone 55-l) carrying the coat protein gene (cp) of papaya ringspot virus (PRV) strain HA 5-l have remained symptomless and ELISA-negative for 18 mo. after inoculation with Hawaiian PRV under field conditions. Control plants showed disease symptoms within 1 mo. after manual inoculation or within 4 mo. when aphid populations were the inoculum vectors. Trunk diameter was significantly greater in cp + plants (14.3 cm) than in PRV-infected controls (9.3 cm). Fruit brix, plant morphology, and fertility of cp + plants were all norm al. Segregation analysis in R1 seedlings indicated that 55-1 contains a single transgenic insertion site. PRV resistance in R1 plants was linked with the cp gene, although in some progenies, up to 50% of cp + plants developed mild PRV symptoms more than 3 mo. after inoculation. Preliminary tests suggest that this is not due to genesis of virulent mutant strains of PRV.
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Gore, Lia, Pamela Kearns, Maria Lucia Lee, Carmino Antonio De Souza, Yves Bertrand, Nobuko Hijiya, Linda C. Stork, et al. "Phase II trial of dasatinib (DAS) in pediatric patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 10511. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.10511.
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10511 Background: Safe and effective treatment options for newly diagnosed (ND) or imatinib (IM) resistant/intolerant (R/I) pediatric CML pts are limited, and a large prospective study is needed. DAS has proven safety and efficacy in adults with ND or IM-R/I CML and is now being evaluated in a phase II trial of pediatric pts. Methods: CA180-226/NCT00777036 is an open-label nonrandomized prospective study of pts aged <18 y in 3 cohorts: (1) CML-CP R/I to IM treated with DAS tablets 60 mg/m2 QD, (2) IM-R/I CML-AP/BP or Ph+ ALL (enrollment closed early due to poor response), and (3) ND CML-CP treated with DAS tablets 60 mg/m2 or DAS 72 mg/m2powder for oral suspension (PFOS) QD. Primary objectives were major cytogenetic response (MCyR) for CML-CP R/I to IM and complete cytogenetic response (CCyR) for ND CML-CP (MCyR >30% and CCyR >55% considered of clinical interest). Results: 113 pediatric CML-CP pts were treated. Cumulative rate of MCyR >30% was reached as early as 3 mo (55%; [95% CI 36, 74]) for IM-R/I CML-CP. Cumulative rate of CCyR >55% was reached as early as 6 mo (64% [95% CI 53, 74] for ND CML-CP; 61% [95% CI 46, 74] for pts on tablets and 70% [95% CI 51, 84] for pts on PFOS). Estimated PFS by 48 mo was >75% for CML-CP R/I to IM and >90% for ND CML-CP. One CML-CP pt R/I to IM died 1 y after stopping DAS from gastrointestinal bleeding. AEs were consistent with those observed in adults, except no DAS-related pleural/pericardial effusion or pulmonary arterial hypertension (PAH) were reported here. Conclusions: In the largest prospective trial of pediatric pts with CML-CP, target responses were met early and increased over time with DAS treatment. The efficacy and safety of DAS were consistent with previous reports in adults, except no cases of pleural/pericardial effusion or PAH were observed. These results suggest DAS is safe and highly effective in the first- or second-line treatment of pediatric CML-CP. Clinical trial information: NCT00777036. [Table: see text]
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Braga, Ermino, Ermino Braga Filho, Jamile Andréa Rodrigues da Silva, Cristian Faturi, Felipe Nogueira Domingues, and José De Brito Lourenço Júnior. "Ruminal degradability of tropical leguminous plants from eastern Amazonia." Semina: Ciências Agrárias 39, no. 2 (March 15, 2018): 845. http://dx.doi.org/10.5433/1679-0359.2018v39n2p845.
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The aim of this study was to evaluate ruminal degradation of dry matter (DM), crude protein (CP), and neutral detergent fiber (NDF) of Cratylia argentea, Flemingia macrophylla (Willd.) Merrill, and Stylosanthes guianensis ‘Campo Grande’ (EMBRAPA), aged 55 and 75 days, in sheep with rumen cannulas, using the in-situ technique. A factorial design of 3 leguminous plants × 2 ages × 6 incubation times was used, totaling 36 experimental units. The experimental period included 14 days for adaptation to diet and 5 days for data collection. Cratylia at both ages and Flemingia aged 55 days showed the highest “a” fraction values for DM degradability. Cratylia aged 55 days and Stylosanthes at both ages showed the highest “a” fraction values for CP. The highest “b” fraction value for DM was 51.27% for Stylosanthes aged 55 days. This rate was lower for the other leguminous plants, especially for Flemingia at both ages. The “b” fraction values for NDF are considered low for Flemingia, what may be the result of lower ruminal degradation. The highest “c” fraction degradation rate for DM was observed in all leguminous plants studied aged 75 days. The highest “c” fraction value for CP was 14.84% for Stylosanthes aged 75 days. The highest Kd fraction values for DM, NDF, and CP were found in Flemingia. Cratylia, and Stylosanthes aged 75 days presented higher effective degradability (ED) values for DM at 2 and 5%/hour compared to Flemingia at both ages. Cratylia and Stylosanthes had the highest ED values for NDF, regardless of their passage rates. Stylosanthes presented higher ED values for CP at both ages, regardless of its passage rate. The highest DM, NDF, and CP potential degradability (PD) was obtained for Cratylia and Stylosanthes, at both ages. The leguminous plants Cratylia and Stylosanthes can be recommended for use as a protein bank and supplementation for ruminants, whereas, Flemingia macrophylla should not be used as a protein supplement for ruminants, because it contains high levels of fibrous fractions.
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Ikoeva, Galina A., Igor E. Nikityuk, Olga I. Kivoenko, Tatyana R. Moshonkina, Irina A. Solopova, Irina A. Sukhotina, Sergei V. Vissarionov, Valery V. Umnov, and Yurii P. Gerasimenko. "Clinical, neurological, and neurophysiological evaluation of the efficiency of motor rehabilitation in children with cerebral palsy using robotic mechanotherapy and transcutaneous electrical stimulation of the spinal cord." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 4, no. 4 (December 14, 2016): 47–55. http://dx.doi.org/10.17816/ptors4447-55.
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Introduction. Rehabilitation of patients with cerebral palsy (CP) remains a very difficult task. Stable and growing movement restrictions in such patients cause a life-long need for treatment and rehabilitation. Neurorehabilitation of children with CP at various stages includes not only traditional physical rehabilitation methods, but also extensive use of robotic mechanotherapy techniques and new technologies in the field of neurophysiology. One of such technology is non-invasive percutaneous electrical stimulation of the spinal cord.Aim of the study: To assess the effect of transcutaneous electrical stimulation of the spinal cord to improve the motor function of children with spastic diplegia using the “Lokomat” robotic mechanotherapy system.Materials and methods. A clinical rehabilitation study of 26 patients aged 6–12 years with CP was conducted. The treatment group included 11 patients who received one course of robotic mechanotherapy using the “Lokomat” system combined with transcutaneous electrical stimulation of the spinal cord. The control group included 15 patients who received one course of robotic mechanotherapy only.Results. A comparative analysis of the two groups based on the results of clinical examinations using specific scales (GMFCS, GMFM-88, Modified Ashworth Scale of Muscle Spasticity), locomotor tests (L-FORCE, L-ROM), and evaluations of muscle activity using electromyography showed that one course of rehabilitation resulted in improvement in motor function in all patients of both groups, but positive dynamics were more significant in the treatment group that underwent percutaneous electrical stimulation of the spinal cord.Conclusion. Based on clinical data, changes in indicators of the locomotor tests L-FORCE and L-ROM, as well as assessment of changes in muscle activity, showed that motor rehabilitation of children with spastic diplegia using the “Lokomat” robotic mechanotherapy system combined with transcutaneous electrical spinal cord stimulation was more effective than robotic mechanotherapy only.
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Waddle, J. A., J. A. Cooper, and R. H. Waterston. "The alpha and beta subunits of nematode actin capping protein function in yeast." Molecular Biology of the Cell 4, no. 9 (September 1993): 907–17. http://dx.doi.org/10.1091/mbc.4.9.907.
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We cloned and analyzed two genes, cap-1 and cap-2, which encode the alpha and beta subunits of Caenorhabditis elegans capping protein (CP). The nematode CP subunits are 55% (cap-1) and 66% (cap-2) identical to the chicken CP subunits and 32% (cap-1) and 48% (cap-2) identical to the yeast CP subunits. Purified nematode CP made by expression of both subunits in yeast is functionally similar to chicken skeletal muscle CP in two different actin polymerization assays. The abnormal cell morphology and disorganized actin cytoskeleton of yeast CP null mutants are restored to wild-type by expression of the nematode CP subunits. Expression of the nematode CP alpha or beta subunit is sufficient to restore viability to yeast cap1 sac6 or cap2 sac6 double mutants, respectively. Therefore, despite evolution of the nematode actin cytoskeleton to a state far more complex than that of yeast, one important component can function in both organisms.
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Nilsson, Tina, Henrik Zetterberg, Yuyan Camilla Wang, and Lars Rymo. "Promoter-Proximal Regulatory Elements Involved in oriP-EBNA1-Independent and -Dependent Activation of the Epstein-Barr Virus C Promoter in B-Lymphoid Cell Lines." Journal of Virology 75, no. 13 (July 1, 2001): 5796–811. http://dx.doi.org/10.1128/jvi.75.13.5796-5811.2001.
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ABSTRACT The identification of the cellular factors that control the transcription regulatory activity of the Epstein-Barr virus C promoter (Cp) is fundamental to the understanding of the molecular mechanisms that control virus latent gene expression. Using transient transfection of reporter plasmids in group I phenotype B-lymphoid cells, we have previously shown that the −248 to −55 region (−248/−55 region) of Cp contains elements that are essential fororiPI-EBNA1-dependent as well asoriPI-EBNA1-independent activation of the promoter. We now establish the importance of this region by a detailed mutational analysis of reporter plasmids carrying Cp regulatory sequences together with or without oriPI. The reporter plasmids were transfected into group I phenotype Rael cells and group III phenotype cbc-Rael cells, and the Cp activity measured was correlated with the binding of candidate transcription factors in electrophoretic mobility shift assays and further assessed in cotransfection experiments. We show that the NF-Y transcription factor interacts with the previously identified CCAAT box in the −71/−63 Cp region (M. T. Puglielli, M. Woisetschlaeger, and S. H. Speck, J. Virol. 70:5758–5768, 1996). We also show that members of the C/EBP transcription factor family interact with a C/EBP consensus sequence in the −119/−112 region of Cp and that this interaction is important for promoter activity. A central finding is the identification of a GC-rich sequence in the −99/−91 Cp region that is essential fororiPI-EBNA1-independent as well asoriPI-EBNA1-dependent activity of the promoter. This region contains overlapping binding sites for Sp1 and Egr-1, and our results suggest that Sp1 is a positive and Egr-1 is a negative regulator of Cp activity. Furthermore, we demonstrate that a reporter plasmid that in addition to oriPI contains only the −111/+76 region of Cp still retains the ability to be activated by EBNA1.
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Manshardt, Richard, and Dennis Gonsalves. "634 Mechanism and Stability of Virus Resistance in Transgenic Papaya." HortScience 34, no. 3 (June 1999): 557A—557. http://dx.doi.org/10.21273/hortsci.34.3.557a.
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Transgenic papaya line 55-1 with resistance to papaya ringspot virus (PRSV) originated in 1989 by particle bombardment of cultivar Sunset with the coat protein gene (cp) of mild mutant Hawaii PRSV strain HA 5-1. Hemizygous (+/cp) R0 clones of 55-1 displayed resistance to the virulent Hawaii HA strain in greenhouse tests in New York in 1991 and to local strains in a field trial in Hawaii from 1992 to 1994. In the R1 generation produced by crossing the pistillate R0 55-1 with `Sunset', up to 50% of the hemizygous transgenic segregants were susceptible to a local Oahu PRSV strain when inoculated as seedlings but not as mature plants. Similar inoculation experiments in New York showed that hemizygous R1 transgenics were susceptible in differing degrees to PRSV strains from regions other than Hawaii. Homozygous (cp/cp) R2, R3, and R4 populations planted in various locations in Hawaii since 1994 have consistently demonstrated high-level resistance to local strains at all stages of development. When inoculated in New York with eight non-Hawaii PRSV strains, homozygous R3 seedlings were resistant to all but a Thai strain. Transgenic resistance is the result of a complex interaction involving the stage of plant development, transgene dosage, the degree of homology between transgene and challenge virus, and environmental variables. Papaya plants transformed with nontranslatable versions of various cp genes are also highly resistant to PRSV, indicating that the resistance mechanism operates at the RNA level. No loss of resistance due to the appearance of resistance-breaking virus strains or to transgene inactivation has been noted thus far.
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Gore, Lia, Pamela R. Kearns, Maria Lucia de Martino, Lee, Carmino Antonio De Souza, Yves Bertrand, Nobuko Hijiya, et al. "Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial." Journal of Clinical Oncology 36, no. 13 (May 1, 2018): 1330–38. http://dx.doi.org/10.1200/jco.2017.75.9597.
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Purpose Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for treatment of adults and children with CML-CP. A phase I study determined suitable dosing for children with Philadelphia chromosome–positive (Ph+) leukemias. Methods CA180-226/NCT00777036 is a phase II, open-label, nonrandomized prospective trial of patients < 18 years of age receiving dasatinib. There are three cohorts: (1) imatinib-resistant/intolerant CML-CP, (2) imatinib-resistant/intolerant CML in accelerated/blast phase or Ph+ acute lymphoblastic leukemia (n = 17), and (3) newly diagnosed CML-CP treated with tablets or powder for oral suspension. Major cytogenetic response > 30% for imatinib-resistant/intolerant patients and complete cytogenetic response (CCyR) > 55% for newly diagnosed patients were of clinical interest. Results Of 113 patients with CML-CP, 14 (48%) who were imatinib-resistant/intolerant and 61 (73%) who were newly diagnosed remained on treatment at time of analysis. Major cytogenetic response > 30% was reached by 3 months in the imatinib-resistant/intolerant group and CCyR > 55% was reached by 6 months in the newly diagnosed CML-CP group. CCyR and major molecular response by 12 months, respectively, were 76% and 41% in the imatinib-resistant/intolerant group and 92% and 52% in newly diagnosed CML-CP group. Progression-free survival by 48 months was 78% and 93% in the imatinib-resistant/intolerant and newly diagnosed CML-CP groups, respectively. No dasatinib-related pleural or pericardial effusion, pulmonary edema, or pulmonary arterial hypertension were reported. Bone growth and development events were reported in 4% of patients. Conclusion In the largest prospective trial to date in children with CML-CP, we demonstrate that dasatinib is a safe, effective treatment of pediatric CML-CP. Target responses to first- or second-line dasatinib were met early, and deep molecular responses were observed. Safety of dasatinib in pediatric patients was similar to that observed in adults; however, no cases of pleural or pericardial effusion or pulmonary arterial hypertension were reported.
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Güçlü, F. M., and H. Çimenoğlu. "The Recrystallization Behaviour of CP-Titanium." Materials Science Forum 467-470 (October 2004): 459–64. http://dx.doi.org/10.4028/www.scientific.net/msf.467-470.459.
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In the present investigation, recrystallization of Grade-2 quality commercial purity titanium (CP-Ti) has been studied. CP-Ti was received as 4 mm thick plate having hardness of 202 HV0.3. Upon rolling about 55, 70 and 85 % at room temperature, the hardness increased to 268, 276 and 283 HV0.3, respectively. Cold rolled samples were then subjected to isothermal annealing in salt bath at 550-700°C. After measuring hardness, recrystallization curves were plotted for each annealing temperature. Recovery region was not clearly visible on the recrystallization curves. Heavily cold worked samples were soften rapidly and reached to the grain growth region at shorter annealing times. According to Arrhenius plot, recrystallization activation energy of CP-Ti was calculated in between 89,5 and 78,6 kJ/mol. The higher the cold working, the lower is the recrystallization activation energy.
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Manshardt, R., S. Lius, D. Gonsalves, M. Fitch, J. Slightom, and J. Sanford. "Stability of PRV Resistance in Transgenic Papaya." HortScience 30, no. 4 (July 1995): 904A—904. http://dx.doi.org/10.21273/hortsci.30.4.904a.
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Transgenic papaya lines carrying the coat protein gene (CP) of papaya ringspot virus (PRV) strain HA 5-1 display PRV reactions ranging from complete susceptibility (39-3 & 39-4), to slight delay in onset of symptoms (39-1) and attenuation of symptoms (60-3), to high-level resistance (55-1, 63-1). Normal Mendelian segregation of transgene expression was lost in R1 of 39-3 and 39-4, and inbred R1 60-3 gave an aberrant 1:1 ratio. R0 55-1 plants were resistant in the field (Hawaii) for 2 years following manual and/or aphid inoculation, and the high-level resistance remained stable in the R1 after repeated manual inoculations in the greenhouse and graft inoculation for up to 1 year (Cornell). However, inoculation with PRV HA-Oahu strain produced symptoms in some plants at Cornell (9% after 6 weeks) and in Hawaii (50% after 1 year). Two 55-1 and one 60-3 plant subsequently underwent remission of symptoms and became ELISA-negative (Hawaii). Transmission of PRV isolates from symptomatic 55-1 plants to other CP+ 55-1 bioassay plants was unsuccessful.
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Lazoura, E., M. I. Aguilar, and M. J. McLeish. "Studies on the conformational properties of CP-1042−55 , the hinge region of CP-10, using circular dichroism and RP-HPLC." Journal of Peptide Research 55, no. 6 (June 2000): 411–18. http://dx.doi.org/10.1034/j.1399-3011.2000.00690.x.
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Yen, H. T., D. J. A. Cole, and D. Lewis. "Amino acid requirements of growing pigs. 7. The response of pigs from 25 to 55 kg live weight to dietary ideal protein." Animal Science 43, no. 1 (August 1986): 141–54. http://dx.doi.org/10.1017/s0003356100018432.
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ABSTRACTOne hundred and twenty pigs were used in a 3 × 8 factorial design. The factors were sex, 40 trios of littermate boars, castrated males and gilts, and dietary lysine, eight concentrations from 7×5 to 14×5 g/kg diet with 1 g/kg diet intervals of lysine with corresponding crude protein (CP) concentrations from 114 to 226 g/kg diet. Increases in dietary lysine were associated with concomitant increases in the other essential amino acids so as to provide an ideal protein. All diets had similar digestible energy values (13·65 MJ/kg). Pigs were fed once daily on a restricted scale from 25 to 55 kg live weight. For growth and carcass characteristics there was a range of linear response followed by a plateau. The inflexion points of dietary lysine for growth characteristics were at 11·1, 10·2 and 10·9 g/kg diet (171, 157 and 168 g CP per kg diet) together with daily intakes of 18·0, 16·7 and 17·6 g (daily intake of 277, 257 and 271 g CP) for boars, castrated males and gilts respectively. The equivalent points for carcass characteristics were 10·4, 9·7 and 10·1 g/kg (160, 149 and 156 g CP per kg diet) with daily intakes of 16·9, 15·9 and 16·4 g lysine (daily intakes of 260, 245 and 252 g CP). Blood urea data gave good support for these observations.
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Chouhab, Y., T. Lefebvre, C. Forestier, P. Parsis, and M. Martinez. "Analyse des courriers de plainte adressés au service d’urgence d’un centre hospitalier général." Annales françaises de médecine d’urgence 9, no. 6 (June 17, 2019): 362–68. http://dx.doi.org/10.3166/afmu-2019-0176.
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Objectif : L’objectif principal de notre travail était d’analyser les courriers de plainte (CP) adressés à un service d’urgence (SU). L’objectif secondaire était de déterminer s’il existait une corrélation entre CP et temporalité de passage au SU. Matériel et méthodes : Étude rétrospective monocentrique sur six ans portant sur les CP concernant les prises en charge en SU. Résultats : Quatre-vingt-un CP ont été analysés, la moyenne annuelle et l’incidence étaient de 13,5 CP/an et de 5,5 CP/ 10 000 passages. L’incidence était de 3,5 CP/10 000 passages pour les enfants vs 6,1 CP/10 000 passages pour les adultes (p = 0,11). Le plaignant était la famille dans 44 CP (55 %) et le patient dans 34 CP (42 %). Il n’y avait pas de différence significative entre le jour et la nuit (5,7 CP/10 000 vs 4,8 CP/ 10 000 passages ; p = 0,57) ni entre horaires de garde et horaires hors garde (5,6 CP/10 000 vs 5,2 CP/10 000 passages ; p = 0,78). Nous avons dénombré 133 doléances, avec une cause médicale dans 64 CP (48 %), une cause organisationnelle dans 44 CP (33 %), une cause relationnelle dans 25 CP (19 %). Une indemnisation financière a été demandée dans 13 CP (16 %) et a été accordée pour deux dossiers (2 %). Aucun CP n’a entraîné de poursuite en justice. Conclusion : L’incidence des CP de notre SU reste dans la moyenne basse des données retrouvées au niveau national et sans relation avec la temporalité du passage. L’analyse des CP permet d’améliorer la qualité de la prise en charge et de proposer des mesures correctives en relation avec la commission des usagers.
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SHINDE, A. K., S. K. SANKHYAN, R. BHATTA, and D. L. VERMA. "Seasonal changes in nutrient intake and its utilization by range goats in a semi-arid region of India." Journal of Agricultural Science 135, no. 4 (December 2000): 429–36. http://dx.doi.org/10.1017/s0021859699008357.
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This study was carried out from September 1998 to August 1999, by conducting three experiments, one each in the monsoon, winter and summer seasons. The forage availability and botanical composition of native range were obtained. Five 3–4-year-old Kutchi males, weighing 50–55 kg, were used to determine total faecal output, and were observed to allow the diet selected to be sampled by the hand plucking method. Dry matter (DM) yield of range was highest during winter and lowest during monsoon, annual mean being 1611 kg DM/ha. Contribution of shrub foliage to total forage yield in monsoon, winter and summer was 3·81, 1·64 and 9·98%, respectively. Crude protein (CP) content (g/kg DM) of ground vegetation declined from 99 in monsoon to 72 in winter and 66 in summer, while that of top foliage remained similar in all the seasons (mean CP 142 g/kg). Goats consumed a diet of almost the same CP content (mean CP 137 g/kg) in all the seasons. Goats consumed 64·0, 54·0 and 55·9 g DM/kg W0·75/day, in monsoon, winter and summer (annual mean 58·0 g DM/kg W0·75 /day). DM and CP digestibility coefficients were higher in monsoon and summer (mean DM 0·595; CP 0·533) and decreased (P < 0·05) in winter (DM 0·485, CP 0·424). Neutral detergent fibre (NDF) and acid detergent fibre (ADF) digestibility coefficients were highest in monsoon (NDF 0·542; ADF 0·446), and declined (P < 0·05) to 0·340 and 0·266 in winter and 0·415 and 0·326 in summer. Digestible crude protein (DCP) intake was almost similar in monsoon and summer (mean 4·6 g/kg W0·75 /day) and declined (P < 0·05) in winter (3·1 g/kg W0·75 /day), while metabolizable energy (ME) intake was higher in monsoon (0·90 MJ/kg W0·75 /day) and declined (P < 0·05) to 0·78 and 0·80 MJ/kg W0·75 /day, in winter and summer, respectively. Average body weight of goats in monsoon, winter and summer was 54·0, 54·6 and 56·5 kg, respectively (annual mean 55·0 kg). It is concluded that goats grazing on a semi-arid rangeland meet their DCP and ME requirement throughout the year.
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Rashid, Omar Maen, Jose Mario Pimiento, Gregory M. Springett, and Mokenge Peter Malafa. "Outcomes of a clinical pathway for borderline resectable pancreatic cancer." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 374. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.374.
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374 Background: While multimodality therapy for borderline resectable pancreatic adenocarcinoma (BPA) is advocated, treatment regimens vary by institution without a standardized approach supported by prospective randomized data. We implemented a multidisciplinary multimodality clinical pathway (CP) for the management of BPA and examined outcomes to investigate optimal therapy. Methods: From January 1, 2006, to December 31, 2013, BPA cases as defined by the NCCN and AHPBA consensus guidelines were managed prospectively along CP. Resection rates, margin status, pathologic response, and overall survival were retrospectively examined. Standard statistical and survival analysis were used. Results: 121 patients were classified as BPA and 101 entered the CP. The neoadjuvant chemoradiation (NT) completion rate was 93.1%. Of those who entered the CP, 55 patients (54.5%) underwent pancreatectomy. R0, R1 and R2 margin rates were 96.3%, 3.7% and 0%, respectively. Of the 55 patients who underwent resection, 22 (40%) required vascular reconstruction, with R0, R1 and R2 margin rates of 95.2%, 4.8%, and 0%, respectively. Pathologic response to treatment was found in 70.8%, with a complete response rate of 15.9%. Median overall survival in the resected group versus the non-resected group was 34.2 months versus 14.7 months, p<0.001. Conclusions: Our series represents one of the largest reports of BPA in the literature and implementation of our CP resulted in a high NT completion rate and pancreatectomy with negative margin rate. Although 41.4% of cases were not resectable after NT, there was a high rate of negative margin resection with >70% pathologic response rate and a favorable median survival.
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Nagy, Eszter, Nelli Farkas, and Katalin Hollódy. "Does Co-occurred Cerebral Palsy Change the Prognosis of West Syndrome?" Neuropediatrics 51, no. 01 (October 22, 2019): 030–36. http://dx.doi.org/10.1055/s-0039-1698450.
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Abstract Aim We aimed to examine the occurrence of cerebral palsy (CP) in children with West syndrome (WS), to estimate the possible causative factors by analyzing the neuroimaging examinations of patients, to evaluate their cognitive/motor function and epileptic status and to compare the prognosis of children with double pathology of WS and CP and of those without CP. Methods The clinical and magnetic resonance imaging (MRI) data of 62 patients with West syndrome were evaluated. A total of 39 of 62 patients (63%) suffered from CP (CP group). The non-CP group included 23 patients. Results Abnormal MRI was found in 55/62 (89%) patients. Main anomalies were: brain malformation (21), hypoxic-ischemic encephalopathy (13), cerebrovascular insult (8), infection (7), and other anomalies (6). In the CP group, the most common MRI abnormalities included pre/perinatal hypoxia/ischemia, brain malformation, cerebrovascular insult, and infection. In the non-CP group, brain malformations were the most frequent. Significantly more negative MRIs were found in the non-CP group. More than 60% of the patients were severely cognitively impaired, almost 90% of them had CP. Not only the occurrence of intellectual disability was lower in the non-CP group, but its severity was milder as well. A total of 78% of the children with CP had a very severe motor disability. Fifty-four percent in the CP and 67% in the non-CP group had therapy-resistant epilepsy. Conclusion WS has an especially unfavorable prognosis: cerebral anomaly was confirmed in 89% of our patients. CP was present in almost two-thirds of the children with WS, most of them had severe cognitive and motor deficits.
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Dulnev, V. V., and Т. A. Slyusar. "Multi-modal (visual, acoustic, cognitive) evoked potentials in children with cerebral palsy." Medical alphabet, no. 22 (October 20, 2020): 52–55. http://dx.doi.org/10.33667/2078-5631-2020-22-52-55.
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The objective. To assess and compare the multi-modal evoked potentials (EP) (flash visual [fVEP], brainstem acoustic [BAEP] and cognitive evoked responses [CER]) parameters in children with cerebral palsy (CP) and healthy ones.Materials and methods. There are 100 children aged 3–17 years were examined. Experimental group included 55 children with CP, diagnosed according to International cerebral palsy criteria (P. Rosenbaum et al., 2006), and mild motor deficit (levels I–II of Gross Motor Function Classification Scale), undergoing rehabilitation course. Control group was presented by 45 healthy children aged 3–17 years with no neurological signs. Registration of the fVEP, BAEP and CER and their comparative analysis with non-parametric tests was performed. Neurophysiological recording performed on EMG-VP4 system (MBN Scientific Company, Moscow, Russia).Results. Slowing of maturation and significant delaying of main EP components were observed in experimental group.Conclusion. Findings in this investigation indicate the retardation of cortical sensory processing in children with CP. Analyzing multi-modal EP may be helpful in early detecting sensory abnormalities as complications of CP.
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D., Krishna Prasad, B. Rajendra Prasad, and Anupama Prasad D. "A Study to Relate Sagittal Condylar Path and Horizontal Incisal Path with Bilateral Balanced Occlusion in Edentulous Subjects." Journal of Health and Allied Sciences NU 10, no. 01 (April 2020): 31–41. http://dx.doi.org/10.1055/s-0040-1710705.
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Abstract Introduction Bilateral balanced occlusion is achieved when there is equilibrium on both sides of the prosthesis, due to the simultaneous contact of the artificial teeth in centric and eccentric occlusion. One of the areas in which research is lacking is the relation between sagittal condylar path (CP) and horizontal incisal path (IP) with optimal balanced occlusion. Materials and Methods Semiadjustable Articulator Artex Arcon AP with Rotofix facebow, 40 µ Bosch articulating paper of red and blue color, protractor, centric and protrusive interocclusal plaster records were used for the study on 50 completely edentulous subjects. Teeth arrangement was done with optimal balanced occlusion, and the numbers of contacts were recorded in centric relation and eccentric positions. Statistical analysis was done by using student’s t test and Karl Pearson coefficient correlation. Results The average sagittal CP was 30.38° in the age group of 40 to 55 years and 32.58° in the age group of 56 to 70 years, and the average horizontal IP was 15.79° in the age group of 40 to 55 years and 16.04° in the age group of 56 to 70 years.Statistically significant results were found between sagittal CP, horizontal IP with bilateral balanced occlusion in the age group of 40–55 years. Conclusion Statistically significant relations were found in balanced occlusion between waxed up denture on articulator, processed denture on articulator and processed denture on articulator after selective grinding. Balanced occlusion is more predictable in a younger group of individuals.
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Tennant, Paula, Manoel T. Souza, Dennis Gonsalves, Maureen M. Fitch, Richard M. Manshardt, and Jerry L. Slightom. "Line 63-1: A New Virus-resistant Transgenic Papaya." HortScience 40, no. 5 (August 2005): 1196–99. http://dx.doi.org/10.21273/hortsci.40.5.1196.
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The disease resistance of a transgenic line expressing the coat protein (CP) gene of the mild strain of the papaya ringspot virus (PRSV) from Hawaii was further analyzed against PRSV isolates from Hawaii and other geographical regions. Line 63-1 originated from the same transformation experiment that resulted in line 55-1 from which the transgenic commercial cultivars, `Rainbow' and `SunUp', were derived. Plants of line 63-1 used in this study consisted of a population from a self pollinated R0 bisexual plant. ELISA and PCR tests provided evidence that there are at least two segregating CP loci. To allow for comparison with reactions of the previously reported line 55-1, virus isolates from Hawaii, Brazil, Thailand, and Jamaica were used to challenge seedlings of 63-1. Unlike line 55-1, a significant percentage of inoculated transgenic plants were susceptible to isolates from Hawaii. However, a proportion of plants were resistant to the non-Hawaiian isolates. In contrast, previous work showed that all plants of the hemizygous line 55-1 were susceptible to PRSV isolates from Brazil, Thailand, and Jamaica. Line 63-1, therefore, presents Hawaii with PRSV-resistant transgenic germplasm that could be used as a source of transgenes for resistance to PRSV isolates within and outside of Hawaii.
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Man, Michal, and Bernard L. Epel. "Characterization of regulatory elements within the coat protein (CP) coding region of Tobacco mosaic virus affecting subgenomic transcription and green fluorescent protein expression from the CP subgenomic RNA promoter." Journal of General Virology 85, no. 6 (June 1, 2004): 1727–38. http://dx.doi.org/10.1099/vir.0.79838-0.
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A replicon based on Tobacco mosaic virus that was engineered to express the open reading frame (ORF) of the green fluorescent protein (GFP) gene in place of the native coat protein (CP) gene from a minimal CP subgenomic (sg) RNA promoter was found to accumulate very low levels of GFP. Regulatory regions within the CP ORF were identified that, when presented as untranslated regions flanking the GFP ORF, enhanced or inhibited sg transcription and GFP expression. Full GFP expression from the CP sgRNA promoter required more than the first 20 nt of the CP ORF but not beyond the first 56 nt. Further analysis indicated the presence of an enhancer element between nt +25 and +55 with respect to the CP translation start site. The inclusion of this enhancer sequence upstream of the GFP ORF led to elevated sg transcription and to a 50-fold increase in GFP accumulation in comparison with a minimal CP promoter in which the entire CP ORF was displaced by the GFP ORF. Inclusion of the 3′-terminal 22 nt had a minor positive effect on GFP accumulation, but the addition of extended untranslated sequences from the 3′ terminus of the CP ORF downstream of the GFP ORF was basically found to inhibit sg transcription. Secondary structure analysis programs predicted the CP sgRNA promoter to reside within two stable stem–loop structures, which are followed by an enhancer region.
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Devery, J. M., N. J. King, and C. L. Geczy. "Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro." Journal of Immunology 152, no. 4 (February 15, 1994): 1888–97. http://dx.doi.org/10.4049/jimmunol.152.4.1888.
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Abstract The murine S100 chemotactic protein of m.w. 10,000 termed (CP-10), has potent chemotactic activity for murine and human myeloid cells. We examined the ability of a synthetic CP-10 hinge region peptide CP-10(42-55) and rCP-10 to act as chemotactic agents and induce expression of the adhesion molecule Mac-1 (CD 11b/CD 18) in vivo. Maximal neutrophil (PMN) accumulation occurred between 2 to 8 h after mouse footpad injection of rCP-10 (10(-7) M) or CP-10 peptide (10(-6) M). The infiltrating PMN expressed high levels of Mac-1, and low levels of the murine L-selectin Mel-14. Injection of CP-10 peptide i.p. also induced infiltration of PMNs that expressed high levels of Mac-1. Cell suspensions obtained after i.p. injection of CP-10 peptide could be significantly inhibited from adhering to fibrinogen-coated plates when incubated with anti-Mac-1 antibody. The chemotactic activity of CP-10 peptide toward murine inflammatory PMN in vitro was also inhibited by anti-Mac-1 antibody. Neither CP-10 analogue stimulated or primed murine inflammatory or human blood neutrophils for superoxide production or granular enzyme release. The localization of CP-10 in vivo was examined using murine footpads injected with LPS and was found to be concentrated around the endothelial cells of the small blood vessels. This distribution suggests that the accumulated CP-10 the may contribute to the generation of a chemotactic gradient.
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Forde, Patrick M., Zhuoxin Sun, Valsamo Anagnostou, Hedy L. Kindler, William T. Purcell, Bernardo H. L. Goulart, Arkadiusz Z. Dudek, Hossein Borghaei, Julie R. Brahmer, and Suresh S. Ramalingam. "PrE0505: Phase II multicenter study of anti-PD-L1, durvalumab, in combination with cisplatin and pemetrexed for the first-line treatment of unresectable malignant pleural mesothelioma (MPM)—A PrECOG LLC study." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 9003. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9003.
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9003 Background: First-line CP was FDA-approved in 2004 for unresectable MPM. Given the role of inflammation in MPM and promising responses to PD-1 pathway blockade in pretreated MPM, we conducted a phase 2 single arm study of the anti-PD-L1 antibody, durvalumab (durva), combined with CP for patients (pts) with untreated MPM of any subtype. Methods: Eligible pts were treatment-naïve with surgically unresectable MPM. Primary endpoint was overall survival (OS); pts received up to 6 cycles of durva-CP, followed by maintenance durva up to 1 year. Carboplatin was permitted for pts with baseline hearing or renal impairment. The first 15 pts were monitored for dose-limiting toxicities (DLTs). Secondary endpoints included toxicity, objective response by modified RECIST, progression-free survival (PFS), and correlative analyses. With a sample size of 55 patients and 32 events, the study had 90% power to detect a 58% improvement in median OS from 12 months (m) (historical control) to 19 m with durva-CP. Results: PrE0505 enrolled 55 patients at 15 US-based sites between 06/2017 and 06/2018. Histologic subtypes were epithelioid (75%), biphasic (11%), sarcomatoid (13%), and desmoplastic (2%). There were no DLTs during the run-in period. As of January 2020 the median follow up is 20.6 m and 29 deaths have occurred. The median OS at the time of report is 21.1 m. The 12 m OS rate was 70% with a 2 sided 95% confidence interval (56%, 81%) and two-sided 80% CI (62%, 78%). Analyses for the secondary endpoints were ongoing at abstract submission. Exome sequencing, TCR sequencing and dual PD-L1/CD8 staining have been completed on baseline tumors from at least 45 of the 55 patients enrolled as well as RNA sequencing for those with adequate tissue. Initial results show that tumors harbored an average tumor mutation burden of 22 somatic sequence alterations and varying levels of aneuploidy were detected. Conclusions: The combination of chemotherapy with durvalumab delivered a promising median OS for previously untreated pts with unresectable MPM. Full results from the study along with the extensive correlative analyses performed will be reported. The phase 3 PrE0506/DREAM3R trial evaluating CP-durvalumab versus CP alone will commence enrollment in the United States and Australia in 2020. Clinical trial information: NCT02899195.
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Maritan, Ana C., José O. Gaspar, and Luis E. A. Camargo. "Identificação e caracterização de um potyvírus isolado de Zinnia elegans." Fitopatologia Brasileira 29, no. 1 (February 2004): 24–29. http://dx.doi.org/10.1590/s0100-41582004000100005.
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O presente trabalho teve como objetivo a identificação e caracterização de um potyvírus isolado de Zinnia elegans, na Região Noroeste do Estado de São Paulo. O potyvírus foi transmitido por inoculação mecânica e apresentou uma gama restrita de hospedeiras sendo que as espécies mais afetadas pertencem à família Asteraceae. Em SDS-PAGE, a massa molecular da proteína capsidial (CP) foi estimada em 33 kDa e, em "Western-blot", reagiu com anti-soro para o Bidens mosaic virus (BiMV). Um fragmento de aproximadamente 820 pb foi amplificado por RT/PCR, clonado e seqüenciado. O fragmento, que inclui o gene da proteína capsidial, mostrou similaridade de aminoácidos do "core" da CP variando de 55% (Tobacco vein mottling virus, TVMV) a 95% (Sunflower chlorotic mottle virus, SuCMoV) e da CP completa de 55% (TVMV) a 91% (SuCMoV). Na região N-terminal, o potyvírus de Zinnia tem uma deleção de quatro aminoácidos (posições 9 a 12 após o sítio de clivagem entre a proteína NIb e a CP) quando comparada com a seqüência do SuCMoV. A análise filogenética agrupou o potyvírus de Zinnia e o SuCMoV em um mesmo ramo em 100% das réplicas, mostrando uma relação de parentesco muito próxima entre esses dois vírus. Os resultados obtidos no presente trabalho demonstraram que o potyvírus de Zinnia e o SuCMoV são estirpes do mesmo vírus. Sugere-se o nome Sunflower chlorotic mottle virus, isolado Zinnia (SuCMoV-Zi), ao potyvírus encontrado em Z. elegans no Brasil.
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Boukhemkhem, Ali, Kamel Rida, Alejandro H. Pizarro, Carmen B. Molina, and Juan J. Rodriguez. "Iron catalyst supported on modified kaolin for catalytic wet peroxide oxidation." Clay Minerals 54, no. 1 (March 2019): 67–73. http://dx.doi.org/10.1180/clm.2019.9.
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AbstractAn iron catalyst supported on the modified Tamazert kaolin has been prepared and tested in catalytic wet peroxide oxidation using phenol and 4-chlorophenol (4-CP) as target compounds (100 mg/L initial concentration). Kaolin is not usually employed as a catalytic support due to its low developed porous structure, but its textural properties may be improved upon calcination and acid and basic treatment. The catalyst was characterized by N2 adsorption–desorption and chemical analysis by total-reflection X-ray fluorescence spectroscopy. The catalytic tests were carried out in a batch reactor with a stoichiometric amount of H2O2. The catalytic efficiency was studied within the temperature range of 25–55°C at an initial pH of 3.3 and 1 g/L catalyst. Complete phenol and 4-CP removal was achieved with no significant differences in phenol and 4-CP conversions within the temperature range tested. Meanwhile, total organic carbon (TOC) reduction was greatly favoured by increasing the temperature, which may be partially attributed to a probable contribution of a homogeneous reaction associated with iron leaching. However, this effect might be of limited significance because the highest concentrations of iron in the liquid phase were below 4.5 and 8.5 mg/L in the experiments with phenol and 4-CP, respectively. At 55°C, TOC was reduced by ~70% after 4 h reaction time, with the remaining by-products corresponding almost completely to low-molecular-weight carboxylic acids of very low ecotoxicity.
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Alpay Savasan, Zeynep, Ali Yilmaz, Zafer Ugur, Buket Aydas, Ray Bahado-Singh, and Stewart Graham. "Metabolomic Profiling of Cerebral Palsy Brain Tissue Reveals Novel Central Biomarkers and Biochemical Pathways Associated with the Disease: A Pilot Study." Metabolites 9, no. 2 (February 2, 2019): 27. http://dx.doi.org/10.3390/metabo9020027.
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Cerebral palsy (CP) is one of the most common causes of motor disability in childhood, with complex and heterogeneous etiopathophysiology and clinical presentation. Understanding the metabolic processes associated with the disease may aid in the discovery of preventive measures and therapy. Tissue samples (caudate nucleus) were obtained from post-mortem CP cases (n = 9) and age- and gender-matched control subjects (n = 11). We employed a targeted metabolomics approach using both 1H NMR and direct injection liquid chromatography-tandem mass spectrometry (DI/LC-MS/MS). We accurately identified and quantified 55 metabolites using 1H NMR and 186 using DI/LC-MS/MS. Among the 222 detected metabolites, 27 showed significant concentration changes between CP cases and controls. Glycerophospholipids and urea were the most commonly selected metabolites used to develop predictive models capable of discriminating between CP and controls. Metabolomics enrichment analysis identified folate, propanoate, and androgen/estrogen metabolism as the top three significantly perturbed pathways. We report for the first time the metabolomic profiling of post-mortem brain tissue from patients who died from cerebral palsy. These findings could help to further investigate the complex etiopathophysiology of CP while identifying predictive, central biomarkers of CP.
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Beckerman, Jennifer Kate, Mohammad Alarfaj, Cynthia M. Tracy, Ariel D. Faiwiszewski, and Andrew D. Choi. "Coronavirus disease 2019 (COVID-19)-associated constrictive pericarditis." BMJ Case Reports 14, no. 5 (May 2021): e242018. http://dx.doi.org/10.1136/bcr-2021-242018.
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This report documents a rare case of COVID-19-associated constrictive pericarditis (CP) in the setting of a recent COVID-19 infection. A 55-year-old man with a history of hypertension and gout presented with acute hypoxic respiratory failure and was diagnosed with COVID-19 pneumonia with progression to acute respiratory distress syndrome. His hospital course was complicated by a large pericardial effusion; an emergent bedside transthoracic echocardiography was concerning for cardiac tamponade, so pericardiocentesis was performed. A workup with cardiac magnetic resonance imaging showed changes consistent with a diagnosis of CP. Viral and idiopathic aetiologies are the most common cause of CP in the developed world, with COVID-19 now a proposed predisposing viral illness. The virus induces systemic inflammation and pericardial changes that can lead to CP physiology. Imaging modalities including echocardiogram and cardiac magnetic resonance play an integral role in confirming the diagnosis.
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Shen, Feng, Joon Wayn Cheong, and Andrew G. Dempster. "A DSRC Doppler/IMU/GNSS Tightly-coupled Cooperative Positioning Method for Relative Positioning in VANETs." Journal of Navigation 70, no. 1 (July 14, 2016): 120–36. http://dx.doi.org/10.1017/s0373463316000436.
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Relative position awareness is a vital premise for the implementation of emerging intelligent transportation systems. However, commercial Global Satellite Navigation Systems (GNSS) receivers do not satisfy the requirements of these applications. Fortunately, Cooperative Positioning (CP) systems, based on inter-vehicle communications, have improved performance of relative positioning in a Vehicular Ad Hoc Network (VANET). CP techniques rely primarily on measurements from the Global Positioning System (GPS) to deliver measurements or positions that describe the location of individual vehicles. In urban environments, the reduced quality or complete unavailability of GPS measurements challenges the effectiveness of any CP algorithm. In this paper, a new enhanced tightly–coupled CP technique is presented by adding the measurements from low-cost inertial sensors and the Doppler shift of the carrier of Dedicated Short-Range Communications (DSRC) signals. In the enhanced CP method proposed here, vehicles communicate their Inertial Measurement Unit (IMU) data and GPS measurements. Each vehicle fuses the GPS measurements and IMU data and the inter-node range-rates based on the Doppler shift of the carrier of DSRC signals. Based on analytical and experimental results, in a full GPS coverage environment, the new tight integration CP outperforms tight CP with Inertial Navigation System (INS), tight CP and differential GPS by at least by 6%, 15%, and 28%, respectively. In a GPS outage, the performance improvement can be up to 60%, 55%, and 66% respectively.
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Bower, Kathryn, and Nilay Shah. "Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient." Case Reports in Oncological Medicine 2018 (June 24, 2018): 1–7. http://dx.doi.org/10.1155/2018/5869135.
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With primary central nervous system lymphoma (PCNSL) being a rare disease, the subtype of Burkitt lymphoma (BL) presenting as a sole CNS lesion is an even more exceptional diagnosis. A case of coexistent primary CNS Burkitt lymphoma (PCNSBL) with cerebral palsy (CP) is presented. A 55-year-old Caucasian male presented with increasing bilateral lower extremity weakness above his baseline in addition to signs of increased intracranial pressure. Four abnormal enhancing masses were detected on MRI with biopsy results consistent with Burkitt lymphoma. Complete staging workup was completed with no evidence of extra-CNS disease noted on PET/CT, bone marrow biopsy, or cerebral spinal fluid analysis. The patient was treated with intravenous as well as intrathecal chemotherapy and found to be in a complete remission at six months. Recurrence in the CNS was observed four months later with treatment consisting of whole brain radiation as well as intrathecal chemotherapy. Thirty months after diagnosis, the patient remains disease-free. To our knowledge, this is the first case of PCNSBL in the setting of CP. A review of literature regarding treatment options in this controversial setting is provided.
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Nasim, M., SM Shahidullah, A. Saha, MA Muttaleb, TL Aditya, MA Ali, and MS Kabir. "Distribution of Crops and Cropping Patterns in Bangladesh." Bangladesh Rice Journal 21, no. 2 (September 14, 2018): 1–55. http://dx.doi.org/10.3329/brj.v21i2.38195.
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Agricultural land use and distribution of cultivated crops expressed in cropping pattern (CP) constitute the base for increasing produtivity. An in-depth study was conducted on the existing CPs of Bangladesh in each and every upazila (sub-districts) using semi structured questionnaire and data validation by the stakeholder consultation workshop conducted in each of 64 districts. Three hundred and sixteen CPs were identified throughout Bangladesh excluding the very minor ones. Topmost five CPs were only rice containing CPs, which covered 51% of the net cropped area. The most dominant CP was Boro- Fallow-T. Aman covering 27% of net cropped area. Results on major cropwise CPs, location-wise CPs, CP diversity and crop diversity etc are also presented herein.Bangladesh Rice j. 2017, 21(2): 1-55
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Filippova, Oleksandra, and Volodymyr Krivoshey. "FEATURES OF THE COMORBID COURSE OF CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION." Wiadomości Lekarskie 75, no. 9 (2022): 2275–79. http://dx.doi.org/10.36740/wlek202209217.
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The aim: To investigate the clinical features of the chronic pancreatitis (CP) clinical course in patients with concomitant arterial hypertension. Materials and methods: 100 patients with PD were investigated. In 60 patients, the course of CP and AH was combined - the main group, the comparison group - 40 patients with CP without concomitant pathology. Results: In 52 patients (86.7%) with CP and AH abdominal pain was recorded versus 24 (60.0%) with CP (p<0.01). Correlation analysis revealed weak relationship between the intensity of pain acc. Visual analogue scale (VAS) of pain and the degree of steatorrhea (τ = 0.40, p <0.01), the degree of amilorrhea (τ = 0.39, p <0.01) and the average strength of the relationship with creatorrhoea (τ = 0.60 , p <0.01). Dyspepsia was revealed in CP and AH: flatulence in 55 (91.7%) compared with 26 (65.0%) with CP, diarrhea in 52 (86.7%) patients in the main group versus 23 (57.5%) in the comparison group, nausea in 52 (86.7%), vomiting in 45 (75.0%) in the main group versus 18 (45.0%) and 12 (30.0%) patients from the comparison group (p<0.01 in all comparisons). Asthenia is expressed in patients with CP and AH: weakness in 50 (83.3%) patients versus 6 (15.0%), psychoemotional lability in 44 (73.3%) versus 3 (7.5%), headache in 47 (78.3%) versus 6 (15.0%), sleep disorders in 45 (75.0%) compared with 1 (2.5%) patients with CP (p<0.01 in all comparisons). Conclusions: The negative effect of concomitant hypertension on the clinical course of CP has been established. AH contributes to increased pain syndrome, dyspepsia, asthenia.
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Tamma, Pranita D., Katherine E. Goodman, Anthony D. Harris, Tsigereda Tekle, Ava Roberts, Abimbola Taiwo, and Patricia J. Simner. "Comparing the Outcomes of Patients With Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae Bacteremia." Clinical Infectious Diseases 64, no. 3 (December 24, 2016): 257–64. http://dx.doi.org/10.1093/cid/ciw741.
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Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) are associated with considerable mortality. As mechanisms of carbapenem resistance are heterogeneous, it is unclear if mortality differs based on resistance mechanisms. We sought to determine whether CRE resistance mechanism determination is prognostically informative. Methods We conducted an observational study comparing 14-day mortality between patients with carbapenemase-producing (CP)-CRE compared with non-CP-CRE bacteremia. Clinical data were collected on all patients. A comprehensive DNA microarray-based assay was performed on all isolates to identify β-lactamase-encoding genes. Results There were 83 unique episodes of monomicrobial CRE bacteremia during the study period: 37 (45%) CP-CRE and 46 (55%) non-CP-CRE. The majority of CP-CRE isolates were blaKPC (92%), followed by blaNDM (5%) and blaOXA-48-type (3%). CP-CRE isolates were more likely to have meropenem minimum inhibitory concentrations (MICs) ≥16 µg/mL, while non-CP-CRE isolates were more likely to have meropenem MICs ≤1 µg/mL (P value < .001). A total of 18 (22%) patients died within 14 days, including 12 (32%) in the CP-CRE group and 6 (13%) in the non-CP-CRE group. Adjusting for severity of illness on day 1 of bacteremia, underlying medical conditions, and differences in antibiotic treatment administered, the odds of dying within 14 days were more than 4 times greater for CP-CRE compared with non-CP-CRE bacteremic patients (adjusted odds ratio, 4.92; 95% confidence interval, 1.01–24.81). Conclusion Our findings suggest that CP-CRE may be more virulent than non-CP-CRE and are associated with poorer outcomes. This underscores the added importance of delineating underlying resistance mechanisms of CRE to direct antibiotic treatment decisions.
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Ivonie, Ulfa, Arry Yanuar, and Firdayani . "VIRTUAL SCREENING OF INDONESIAN HERBAL DATABASE FOR CP ALLOSTERIC MODULATOR OF HEPATITIS B VIRUS." International Journal of Applied Pharmaceutics 10, no. 1 (December 20, 2018): 190. http://dx.doi.org/10.22159/ijap.2018.v10s1.42.
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Objective: This study performed a virtual screening of the Indonesian Herbal Database for the core protein allosteric modulator of the hepatitis Bvirus (HBV) using AutoDock and AutoDock Vina software, to discover novel safe drugs for patients.Methods: The method was validated using the parameters enrichment factor (EF), receiver operating characteristics, and area under the curve (AUC).The grid box size used in virtual screening with AutoDock was 55 × 55 × 55 with EF10% of 0.7652 and AUC of 0.6709, whereas that used in virtualscreening with AutoDock Vina was 20.625 × 20.625 × 20.625 with EF5% of 0.5075 and AUC of 0.7832.Results: The top 10 compounds from virtual screening with AutoDock at G levels −11.74–−10.31 kcal/mol were yuehchukene, lansionic acid, stigmast-4-en-3-one, myrtillin, sanggenol O, lanosterol, erycrista-gallin, alpha-spinasterol, cyanidin 3-arabinoside, and cathasterone and with AutoDock Vinaat G levels −12.1 to −10.7 kcal/mol were sanggenol O, cucumerin A, yuehchukene, palmarumycin CP1, dehydrocycloguanandin, myrtillin, liriodenine,myricetin 3-alpha-L-arabinopyranoside, myricetin 3-galactoside, and cassameridine.Conclusion: Three compounds were in top list of both virtual screening methods against Cp allosteric modulator of HBV are myrtillin, sanggenol O,and yuehchukene have a prospect to be investigated futher for anti HBV.
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Ateeq, Hira, Afaf Zia, Qayyum Husain, and Afshan Bey. "Comparative assessment of bone mineral density levels in type 2 diabetic subjects with or without chronic periodontitis: A cross-sectional study." Journal of Advanced Periodontology & Implant Dentistry 13, no. 1 (June 13, 2021): 28–34. http://dx.doi.org/10.34172/japid.2021.008.
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Background. This cross-sectional study investigated the bone mineral density (BMD) in type 2 diabetes mellitus (T2DM) subjects with or without chronic periodontitis (CP). Methods. A total of 120 subjects aged 35‒55, divided equally into four groups: i) T2DM with CP, ii) T2DM without CP, iii) CP alone, and iv) healthy patients, were included in this study. Clinical parameters like plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded. All the participants were evaluated for blood sugar levels using glycated hemoglobin (HbA1c) and BMD by Hologic dual-energy x-ray absorptiometry (DEXA) scan. The association of BMD with clinical periodontal parameters and HbA1c in all groups was investigated using linear correlation analysis (r). Results. The mean value of BMD (0.9020±0.0952 g/cm2) was lower in subjects with both T2DM and CP compared to T2DM and CP alone. BMD was weakly correlated with all the clinical periodontal parameters; a positive correlation was observed between BMD and GI in the T2DM and CP group (r=0.405, P=0.026) and the CP group (r=0.324, P=0.081). A weak positive correlation was observed in BMD and HbA1c in the T2DM group (r=0.261, P=0.13), T2DM and CP group (r=0.007, P=0.970), with a negative correlation to HbA1c in the CP group (r= -0.134, P=0.479). Conclusions: Diabetes mellitus impacts clinical periodontal status and bone mass, and the effect is accentuated when chronic periodontitis is present. Based on the present study, BMD is associated with T2DM and CP, but a weak correlation was observed between BMD and HbA1c and clinical periodontal parameters.
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Anisimkin, Vladimir, Elizaveta Shamsutdinova, Peng Li, Bin Wang, Feng Zhu, Zhenghua Qian, and Iren Kuznetsova. "Selective Detection of Liquid Viscosity Using Acoustic Plate Waves with In-Plane Polarization." Sensors 22, no. 7 (April 1, 2022): 2727. http://dx.doi.org/10.3390/s22072727.
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Using plates of weak piezoeletcric crystal (quartz) loaded with various liquids, it is shown that along with common modes, whose sensitivity towards different liquid parameters comparable with each other, there are some uncommon modes, whose amplitude responses towards viscosity η are much larger than towards temperature T and electric conductivity σ. The search of the modes with the selective properties is accomplished by varying plate thickness h, crystal orientation, wave length λ, and mode order n. It is found that all modes possessing the property are characterized by small surface-normal displacement, avoiding wave radiation into adjacent liquid, large in-plane displacements, enhancing viscous coupling the modes and liquids, and small electro-mechanical constant, reducing electro-acoustic interaction. Basing on the modes, the sensor prototypes with selective operation are developed and tested for η from 1 to 1500 cP, σ from 0 to 1.2 S/m, and t from 0 to 55 °C. Because of operation at ultrasonic frequency (tens MHz) the prototypes have different sensitivities in various η-ranges: 0.3 dB/cP for 1–20 cP, 0.12 dB/cP for 20–100 cP, and 0.015 dB/cP for 100–1500 cP. Viscosity responses of the prototypes become comparable with their electric outputs only for η < 2 cP. Temperature responses are almost zero in air, but when plate is coated with liquid they increase depending on liquid properties, allowing measurements of the temperature dependence of the liquid viscosity.
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BELL, J. M., and M. O. KEITH. "EFFECTS OF BARLEY HULLS, DIETARY PROTEIN LEVEL AND WEIGHT OF PIG ON DIGESTIBILITY OF CANOLA MEAL FED TO FINISHING PIGS." Canadian Journal of Animal Science 68, no. 2 (June 1, 1988): 493–502. http://dx.doi.org/10.4141/cjas88-055.
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A factorial digestibility experiment with three dietary levels of canola meal (CM) (0, 15, 30%), two levels of barley hulls (0, 25%) and two basal diets (approximately 10 and 19% crude protein, CP) was conducted using crossbred pigs over the weight range 45 – 90 kg. Diets contained 0.5% chromium oxide as a fecal marker. Inclusion of barley hulls improved the apparent digestibility of dietary CP (83.3% with hulls vs. 81.9% without hulls) and of corn CP (74% for corn, 76% for corn + hulls). True digestibility of CP in corn was also improved (75% for corn, 90% for corn + hulls). The energy and CP components of barley hulls were 40 and 57% digestible, respectively. The digestibility values for CM were: CP 80% (apparent) and 85% (true); energy 68%; nonprotein energy 55% and these were not affected by the presence of barley hulls. Digestibility improved as the pigs matured; each 10-kg weight increase was associated with 0.65 and 0.37 percentage units increase in digestibility of CP and energy, respectively, but these values may be lower than those normally encountered because of the use of casein for adjusting dietary CP levels in this experiment. It is suggested the barley hulls may possess two opposing properties, one that depresses digestibility of protein by increasing metabolic fecal nitrogen output and which is related to the neutral detergent fiber component, and another that in some way enhances the digestibility of protein. Key words: Canola meal, barley hulls, protein level, digestibility, pigs
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Dufault, Robert J., and Brian Ward. "Impact of Cutting Pressure on Yield, Quality, Root Carbohydrates, and Survival of Spring-harvested or Summer-forced Asparagus." HortScience 40, no. 5 (August 2005): 1327–32. http://dx.doi.org/10.21273/hortsci.40.5.1327.
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Excessive cutting pressure (CP) early in the lifespan of an asparagus (Asparagus officinalis L.) plantation may weaken and reduce yields and quality. The objective of this research was to determine how increasing CP affects yield, quality, and survival of spring-harvested and summer-forced asparagus. `Jersey Gem' asparagus was harvested for 4 years (1999–2002) in spring or summer-forced on 1 Aug. using the following CP (weeks/year from 1st to 4th years, respectively): 2, 3, 4, 6 (low), 3, 4, 5, 7 (medium), and 4, 5, 8, 10 (high). In all harvest years, as CP increased, marketable number and weight increased. Yield in spring harvest seasons significantly increased with each increase in CP. In summer, yield significantly increased only when high CP was used with equivalent yields at low and medium CP. With summer forcing, there were 48% and 55% fewer large spears at medium and high CP, respectively, compared to the same CP used during spring harvest seasons. Stands tended to decrease with CP from 1997 to 2003, but these differences were not significant and not severe enough to kill the plants. Yearly root fructose concentrations (RFC) with all CP increased yearly from 1999 to 2001 and plateaued from 2002 to 2003. From 1999 to 2002, RFC increased 53%, 27%, 13%, and 13% in unharvested control, low, medium, and high CP, respectively, indicating that with a greater CP, RFC decreased. RFC in summer-forced asparagus was significantly less than spring-harvested in 83% of all sample months. RFC in spring-harvested asparagus was similar to unharvested asparagus in February, March, April, November, and December; however, in all other sample months, spring-harvested RFC was significantly lower than unharvested control plants. The highest CP scheme is appropriate for spring-harvested asparagus based on greatest marketable yields and acceptable cull losses. For summer-forced asparagus, the lowest CP scheme is more appropriate based on acceptable marketable yields and to avoid undue plant stress verified by unacceptably large cull losses mostly attributed to spindly spear size and lower RFC.
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Marković, S., M. Odavić, A. Matunović, B. Raičević, S. Prvulov, S. Kamenica, R. Spaić, M. Rostovac, and B. Ajdinović. "Evaluation of Diagnostic Reliability of Radionuclide Phlebography Using 99mTc-MAA to Detect Deep Venous Thrombosis; Its Role in Establishing Indications for Inferior Vena Cava Filter Implantation." Nuklearmedizin 30, no. 06 (1991): 287–89. http://dx.doi.org/10.1055/s-0038-1629589.
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Radionuclide phlebography (RNP) of the lower extremities and pelvis was performed using 99mTc-MAA in 40 patients with pulmonary thromboembolism. Deep venous thrombosis (DVT) was found in all patients, more frequently in the right calf and in the left iliac veins in 20 patients (55%). RNP and contrast phlebography (CP) were performed in 18 patients and confirmed the presence of DVT in all cases. The greatest specificity of RNP was obtained in the left (92.4%) and in the right pelvis (80%). In 12 of 18 patients in whom a cava filter was implanted, specificity of RNP was 100% for the left thigh and 91.7% for other localizations. In establishing indications for cava filter implantation, RNP should be performed prior to CP and bilaterally, but in case of non-indicated CP, RNP findings should be sufficient.
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Mistry, Ravi, Daniel R. Frei, Chris Badenhorst, and James Broadbent. "A survey of self-reported use of cricoid pressure amongst Australian and New Zealand anaesthetists: Attitudes and practice." Anaesthesia and Intensive Care 49, no. 1 (January 2021): 62–69. http://dx.doi.org/10.1177/0310057x20968841.
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We conducted a survey of Australian and New Zealand anaesthetists designed to quantify self-reported use of cricoid pressure (CP) in patients presumed to be at risk of gastric regurgitation, and to ascertain the underlying justifications used to support individual practice. We aimed to identify the perceived benefits and harms associated with the use of CP and to explore the potential impact of medicolegal concerns on clinical decision-making. We also sought to ascertain the views of Australian and New Zealand anaesthetists on whether recommendations relating to CP should be included in airway management guidelines. We designed an electronic survey comprised of 15 questions that was emailed to 981 randomly selected Fellows of the Australian and New Zealand College of Anaesthetists (ANZCA) by the ANZCA Clinical Trials Network on behalf of the investigators. We received responses from 348 invitees (response rate 35.5%). Of the 348 respondents, 267 (76.9%) indicated that they would routinely use CP for patients determined to be at increased risk of gastric regurgitation. When asked whether participants believed the use of CP reduces the risk of gastric regurgitation, 39.8% indicated yes, 23.8% believed no and 36.3% were unsure. Of the respondents who indicated that they routinely performed CP, 159/267 (60%) indicated that concerns over the potential medicolegal consequences of omitting CP in a patient who subsequently aspirates was one of the main reasons for using CP. The majority (224/337; 66%) of respondents believed that recommendations about the use of CP in airway management guidelines should include individual practitioner judgement, while only 55/337 (16%) respondents believed that routine CP should be advocated in contemporary emergency airway management guidelines.
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Kopp, U. C., D. M. Farley, and L. A. Smith. "Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 6 (June 1, 1997): R2009—R2016. http://dx.doi.org/10.1152/ajpregu.1997.272.6.r2009.
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In anesthetized rats, renal pelvic administration of bradykinin results in a prostaglandin (PG)-dependent increase in afferent renal nerve activity (ARNA). We now measured renal pelvic release of PGE and substance P during renal pelvic administration of bradykinin. Bradykinin increased ARNA and renal pelvic release of PGE by 497 +/- 252 pg/min and substance P. by 10.7 +/- 7.2 pg/min. Renal pelvic perfusion with indomethacin abolished the bradykinin-mediated increase in ARNA and reduced renal pelvic release of PGE and substance P by 76 +/- 11 and 72 +/- 8%, respectively. To examine whether the increased substance P release contributed to bradykinin-mediated activation of renal sensory receptors, renal pelvis was perfused with the substance P-receptor antagonists CP-96,345, CP-99,994, or RP-67580. The ARNA response to bradykinin was reduced 73 +/- 11, 55 +/- 12, and 64 +/- 10% by CP-96,345, CP-99,994, and RP-67580, respectively. The inactive enantiomers CP-96,344 and RP-68651 had no effect. These data suggest that bradykinin increases renal pelvic release of PGE, which facilitates the release of substance P, which in turn stimulates substance P receptors. Thus the ARNA response to bradykinin is largely mediated by activation of substance P receptors.
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Lepcha, Isaac, and Harley D. Naumann. "Partitioning of Forage Mass and Nutritive Value in Sunn Hemp Leaf and Stem Components." International Journal of Agronomy 2021 (August 18, 2021): 1–10. http://dx.doi.org/10.1155/2021/5547120.
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Sunn hemp (SH; Crotalaria juncea L.) is a fast-growing, annual, warm-season tropical legume that could complement less productive cool-season forages such as tall fescue during summer. Little is known about seasonal forage mass and nutritive value partitioning in SH plant components when SH is managed for forage. We determined partitioning of forage mass and nutritive value (crude protein (CP), in vitro true digestibility (IVTD), neutral detergent fiber (NDF), acid detergent fiber (ADF), and neutral detergent fiber digestibility (NDFD)) concentrations in SH leaves and stems harvested 35, 45, and 55 days after planting (DAP) at Bradford Research Center, Columbia, MO, in a 2-year field study. Leaf and stem mass increased with increasing DAP and was greatest ( P ≤ 0.05 ) at 55 DAP followed by 45 and 35 DAP. Stems contributed most to the total forage mass beyond 45 DAP. Across years, CP was greatest ( P ≤ 0.05 ) in leaves (281 g kg−1 DM) and lowest for stems (81 g kg−1 DM) at 55 DAP. The lowest NDF ( P ≤ 0.05 ) was observed in leaves (251 g kg−1 DM) and stems (585 g kg−1 DM) at 35 DAP. Acid detergent fiber was lowest ( P ≤ 0.05 ) for SH leaves (178 g kg−1 DM) and stems (484 g kg−1 DM) at 35 DAP. Digestibility of leaves was greater than that of stems and generally decreased with maturity. The nutritive value of leaves was consistently greater than that of stems and decreased with maturity, except for CP of leaves, which was maintained throughout the season. Results suggested that SH leaves can maintain forage mass and greater quality than its stem throughout the growing season.
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Rao, D. S., and K. J. McCracken. "Protein requirements of boars of high genetic potential for lean growth." Animal Science 51, no. 1 (August 1990): 179–87. http://dx.doi.org/10.1017/s0003356100005286.
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ABSTRACTSix replicates (five Landrace and one Duroc) of four littermate entire male pigs were used to evaluate the effect of protein level in diets of constant amino acid composition on live-weight gain, efficiency of gain, nitrogen balance and carcass characteristics. The diet contents ranged from 151 to 282 g crude protein (CP) and 8·5 to 16·4 g lysine per kg dry matter (DM) and were studied over two live-weight ranges, 33 to 55 kg and 55 to 88 kg. All the diets had similar metabolizable energy (ME) values (15·0 MJ/kg DM). Pigs were given food twice daily to appetite. Sixteen pigs (four replicates) were used for metabolism trials at 35 to 43, 58 to 65 and 78 to 88 kg live weight and after attaining a live weight of 88 kg they were slaughtered to assess carcass characteristics. Between 33 and 55 kg live weight significantly linear improvements (P < 0·01) in the daily live-weight gain and in the ratio ME: live-weight gain were observed for daily intakes in excess of 300 g ideal protein and 21 g lysine (212 g CP and 12·5 g lysine per kg DM). Between 55 and 88 kg live weight, linear improvements in the same two variables were observed for daily intakes of 395 g ideal protein and 28 g lysine (212 g CP and 12·5 g lysine per kg DM). For the 33 to 88 kg live-weight period the average ME intake was 30 MJ/day and the predicted intakes for maximum growth and food conversion efficiency were in excess of 370 g ideal protein and 26 g lysine. Nitrogen retention improved significantly with increasing dietary crude protein content in all three balance periods. Fat thickness measurements decreased linearly (P < 0·05) and the proportions of lean and fat in rumpback increased and decreased respectively (P < 0·01) as the dietary protein level increased.
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Ajioka, T., M. Yamamoto, K. Takemura, A. Hayashida, and H. Kitagawa. "Water pH and temperature in Lake Biwa from MBT'/CBT indices during the last 280 000 years." Climate of the Past 10, no. 5 (October 17, 2014): 1843–55. http://dx.doi.org/10.5194/cp-10-1843-2014.
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Abstract. We generated a 280 000 yr record of water pH and temperature in Lake Biwa, central Japan, by analysing the methylation index (MBT′) and cyclisation ratio (CBT) of branched tetraethers in sediments from piston and borehole cores. Our aim was to understand the responses of precipitation and air temperature in central Japan to the East Asian monsoon variability on orbital timescales. Because the water pH in Lake Biwa is determined by phosphorus and alkali cation inputs, the record of water pH should indicate the changes in precipitation and temperature in central Japan. Comparison with a pollen assemblage in a Lake Biwa core suggests that lake water pH was determined by summer temperature in the low-eccentricity period before 55 ka, while it was determined by summer precipitation in the high-eccentricity period after 55 ka. From 130 to 55 ka, the variation in lake pH (summer precipitation) lagged behind that in summer temperature by several thousand years. This perspective is consistent with the conclusions of previous studies (Igarashi and Oba, 2006; Yamamoto, 2009), in that the temperature variation preceded the precipitation variation in central Japan.
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Dewan, Karuna, Chloe Santa Maria, and Julia Noel. "Cricopharyngeal Achalasia: Management and Associated Outcomes—A Scoping Review." Otolaryngology–Head and Neck Surgery 163, no. 6 (June 23, 2020): 1109–13. http://dx.doi.org/10.1177/0194599820931470.
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Objective There is little consensus regarding the efficacy and safety of treatment options for cricopharyngeal (CP) achalasia. The purpose of this scoping review is to assess the literature regarding the various treatments for this disease. Data Sources PubMed was searched for all articles addressing treatment of adult CP achalasia between January 1990 and June 2019. Review Methods In total, 351 peer-reviewed results were reviewed by 3 otolaryngologists for inclusion. After review of titles, abstracts, and full texts, 60 articles were selected. Results Among included studies, 55% were retrospective and 45% were prospective. Forty-five percent of studies were case series. CP achalasia etiologies included idiopathic (28%), cerebrovascular accident (CVA) (28%), neurologic disease (17%), head and neck radiation treatment (11%), Zenker’s diverticulum (10%), and myositis (5%). Most commonly employed treatments were botulinum toxin injection (40%), endoscopic CP myotomy (30%), dilation with either balloon or bougie (25%), and open CP myotomy (15%). A proportion of patients were treated with more than 1 approach. Most studies included both subjective and objective outcome measures. Complications were reported most often in patients with a history of head and neck radiation. Conclusions Small sample sizes and heterogeneity of causes and treatments of CP achalasia, as well as short duration of follow-up, make it challenging to assess the superiority of one treatment over another. There is a need for a prospective study that more directly compares outcomes of administration of botulinum toxin, dilation, and CP myotomy in patients with CP achalasia of similar etiologies.
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Jacobs, P., and HS King. "A randomized prospective comparison of chemotherapy to total body irradiation as initial treatment for the indolent lymphoproliferative diseases." Blood 69, no. 6 (June 1, 1987): 1642–46. http://dx.doi.org/10.1182/blood.v69.6.1642.1642.
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Abstract One hundred eight consecutive patients with indolent lymphoproliferative diseases were stratified into chronic lymphocytic leukemia (CLL), stage III and IV well-differentiated lymphocytic lymphoma (WDLL), and stage III and IV follicular lymphoma (FL). Within each stratum, patients were prospectively and randomly assigned to receive chemotherapy with chlorambucil and prednisone (CP) or fractionated total body irradiation (TBI). Morbidity from both regimens was negligible. Complete response (CR) was defined as the resolution of organ enlargement and the return of blood count to normal. The CR rate for the entire CP group (n = 54) was 59% and that for the TBI group (n = 54), 52%; median survivals were 53 and 57 months respectively. In the 41 patients with CLL the CR rate for CP (n = 17) was 47% and that for TBI (n = 24), 50%; the median survival for CP was 48 months, and for TBI it was 51 months. In the 21 patients with WDLL the CR rate for CP (n = 15) was 53% and that for TBI (n = 6), 67%; the median survival for CP was 42 months and has not yet been reached for TBI. For the 46 patients with FL the CR rate for CP (n = 22) was 72% and that for TBI (n = 24), 50%; the median survival was 55 months, and for TBI it was 56 months. None of the differences in CR or survival are statistically significant (P greater than .05). In these indolent lymphoproliferative diseases, CP and TBI are equally effective forms of initial treatment irrespective of the end point being defined as CR or survival.
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Jacobs, P., and HS King. "A randomized prospective comparison of chemotherapy to total body irradiation as initial treatment for the indolent lymphoproliferative diseases." Blood 69, no. 6 (June 1, 1987): 1642–46. http://dx.doi.org/10.1182/blood.v69.6.1642.bloodjournal6961642.
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One hundred eight consecutive patients with indolent lymphoproliferative diseases were stratified into chronic lymphocytic leukemia (CLL), stage III and IV well-differentiated lymphocytic lymphoma (WDLL), and stage III and IV follicular lymphoma (FL). Within each stratum, patients were prospectively and randomly assigned to receive chemotherapy with chlorambucil and prednisone (CP) or fractionated total body irradiation (TBI). Morbidity from both regimens was negligible. Complete response (CR) was defined as the resolution of organ enlargement and the return of blood count to normal. The CR rate for the entire CP group (n = 54) was 59% and that for the TBI group (n = 54), 52%; median survivals were 53 and 57 months respectively. In the 41 patients with CLL the CR rate for CP (n = 17) was 47% and that for TBI (n = 24), 50%; the median survival for CP was 48 months, and for TBI it was 51 months. In the 21 patients with WDLL the CR rate for CP (n = 15) was 53% and that for TBI (n = 6), 67%; the median survival for CP was 42 months and has not yet been reached for TBI. For the 46 patients with FL the CR rate for CP (n = 22) was 72% and that for TBI (n = 24), 50%; the median survival was 55 months, and for TBI it was 56 months. None of the differences in CR or survival are statistically significant (P greater than .05). In these indolent lymphoproliferative diseases, CP and TBI are equally effective forms of initial treatment irrespective of the end point being defined as CR or survival.
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Hao, Liang, Jin-le Li, Yuan Yue, Ye Tian, Min Wang, Wings TY Loo, Mary NB Cheung, et al. "Application of Interleukin-1 Genes and Proteins to Monitor the Status of Chronic Periodontitis." International Journal of Biological Markers 28, no. 1 (January 2013): 92–99. http://dx.doi.org/10.5301/jbm.5000013.
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It has been widely reported that periodontitis may lead to bone tissue and teeth loss and result in failure of prosthodontics or implants. Interleukin-1 (IL-1) is a potent proinflammatory cytokine that plays an essential role during the pathogenesis of periodontitis. However, the gene polymorphisms of IL-1α, IL-1β and IL-1RN and the relationship between these protein expressions in healthy people and patients with chronic periodontitis (CP) in China have not been fully elucidated. We investigated the gene polymorphisms and protein expression of IL-1α, IL-1β and IL-1RN in healthy subjects and CP patients, and our data suggest that these gene polymorphisms are associated with CP. The frequency of the C/C genotype of IL-1α was 55% in CP patients, while in the control group it was 20% (p<0.0001). The C/C genotype of IL-1β was also higher in CP patients (51%) than in controls (21%) (p<0.0001). For the 2/2 genotype of IL-1RN, CP patients showed a 30% frequency, while in controls this was 15% (p<0.0001). Protein levels evaluated by enzyme-linked immunosorbent assay demonstrated a significant difference in secretion between patients and controls for IL-1α and IL-1β. These results indicate that genotype and protein production of IL-1α, IL-1β and IL-1RN are associated with CP in a Chinese population, and might be putative risk indicators for chronic periodontitis.
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Cancelli, F., A. Oliva, M. De Angelis, M. T. Mascellino, C. M. Mastroianni, and V. Vullo. "Role of Double-Carbapenem Regimen in the Treatment of Infections due to Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae: A Single-Center, Observational Study." BioMed Research International 2018 (November 18, 2018): 1–8. http://dx.doi.org/10.1155/2018/2785696.
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Purpose. (i) To compare infections caused by carbapenem-susceptible (CS) and carbapenemase producing carbapenem-resistant Enterobacteriaceae (CP-CRE); (ii) to evaluate the clinical effectiveness of the double-carbapenem (DC) regimen in comparison with the best available treatment (BAT) in infections caused by CP-CRE; and (iii) to determine the exact minimal inhibitory concentrations (MICs) of meropenem/ertapenem (MEM/ETP) and the degree of in vitro ETP+MEM synergism in subjects receiving the DC. Methodology. Over a 3-year period (2014-2017), patients with infections due to Enterobacteriaceae were included in a single-center, retrospective, observational study. According to the susceptibility to carbapenems, subjects were divided into CSE and CP-CRE groups. CP-CRE group was further divided into subjects receiving the DC regimen and those treated with other regimens (BAT group). Clinical characteristics and the presence of 5th-day response and 60-day outcome were evaluated for DC and BAT groups. The determination of MEM and ETP actual MICs and the MEM+ETP synergistic activity were performed on strains obtained from subjects receiving the DC regimen. Results. A total of 128 patients were included in the study: 55/128 (43%) with infections due to CP-CRE and 73/128 (57%) with infections due to CSE. Among CP-CRE (n=55), 21 subjects (39%) were treated with the DC regimen whereas 34 (61%) received BAT. No differences in terms of severity of infection, presence/absence of concomitant bacteremia, type of infection, and resolution of infection were found; in contrast, DC group tended to have a higher rate of sepsis or septic shock at the onset of infection and a higher rate of 5th-day response. MICs 50/90 were 256/512 and 256/256 μg/mL for MEM and ETP, respectively. Overall, complete in vitro synergism was found in 6/20 strains (30%). Conclusion. The DC regimen is a valid and effective therapeutic option in patients with infections due to KPC producing CRE, including those with bacteremic infection and more severe clinical conditions. The clinical effectiveness is maintained even in the presence of extremely high MEM MICs.
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Hoteit, Maarouf, Christine Cho-Shing Hsu, Matthew H. Levine, Kimberly A. Forde, Kim Anna Reiss, Gregory Nadolski, Michael C. Soulen, et al. "Deterioration of hepatic function after locoregional therapy (LRT) for hepatocellular carcinoma (HCC) measured by hepatic cholate clearance: A pilot study." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 468. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.468.
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468 Background: LRT is used in treating HCC, but is associated with a risk of hepatotoxicity, which is not accurately predicted by traditional measures of liver function. In this pilot study, we evaluated the change in liver function after LRT as measured by a test using dual, oral and IV, cholate clearances (HepQuantSHUNT). Our hypothesis is that LRT would impose a significant reduction in the disease severity index (DSI) measured in the HepQuant SHUNT test, as an indicator of reduced liver function. Methods: We conducted a prospective cohort study of 11 subjects undergoing LRT for HCC. HepQuantSHUNT was performed at baseline (T0) and 4-10 weeks after LRT (T1). Clinical assessment was performed at T0 and T1, and at 12-18 weeks after LRT (T2). Decompensation was defined as either a new complication of cirrhosis or an increase in Child-Pugh (CP) score by ≥2 points. Results: Median age was 61 years, 73% were men, 55% had hepatitis C. Median CP score was 7[5-8], including 36%CP A and 64%CP B. Subjects had a BCLC stage A(64%) or BCLC stage B(36%) HCC. LRT modalities were TACE (45%) or SBRT (55%). From T0 to T1, there was a reduction in oral cholate clearance(422[235-768] vs 339[208-362], p = 0.03) and in IV cholate clearance(210[150-300] vs 191[144-203],p = 0.04) as well as a trend towards a worsening disease severity index (DSI) (32.0[19.5-37.8] vs 33.0[29.7-38.0],p = 0.10); however, there was no significant change in MELD(12[9-13]vs 11[10-12],p = 0.72) or CP score(7[5-8] vs 7[6-8],p = 0.15). 89% of the subjects had a reduction in oral and IV cholate clearance, and 78% had a worsening DSI; while 44% subjects had increase in CP score, and 56% had an increase in MELD. Decompensation was observed in 43% of CP B patients and none of CP A patients; and in 60% patients with a DSI > 35, and none of the patients with DSI < 35. Conclusions: The dual cholate clearance assay HepQuant-SHUNT detects a deterioration in liver function after LRT for HCC more frequently than clinical measures of liver function. DSI 35 might be a cutoff for risk of clinical decompensation after LRT for HCC. Additional research is needed to evaluate the role of the HepQuant SHUNT test in improving the selection of Child B patients for LRT.