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Journal articles on the topic 'Coupled diagnostics'

Author: Grafiati

Published: 29 March 2025

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1

Kovačić, Nada, Gerhard A. Meyer, Liu Ke-Ling, and Ramon M. Barnes. "Diagnostics in an air inductively coupled plasma." Spectrochimica Acta Part B: Atomic Spectroscopy 40, no. 7 (January 1985): 943–57. http://dx.doi.org/10.1016/0584-8547(85)80065-3.

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2

Tadokoro, M., A. Itoh, N. Nakano, Z. L. Petrovic, and T. Makabe. "Diagnostics of an inductively coupled plasma in oxygen." IEEE Transactions on Plasma Science 26, no. 6 (1998): 1724–32. http://dx.doi.org/10.1109/27.747892.

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3

Abdullin, I. Sh, A. N. Bykanov, I. G. Gafarov, O. E. Ibragimov, and R. F. Sharafeev. "Spectral diagnostics of inductively coupled RF discharge plasma." High Energy Chemistry 46, no. 4 (July 2012): 271–75. http://dx.doi.org/10.1134/s0018143912040029.

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4

Hioki, Kazuya, Hajime Hirata, Shosaku Matsumura, Zoran Lj Petrović, and Toshiaki Makabe. "Diagnostics of an inductively coupled CF4/Ar plasma." Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films 18, no. 3 (May 2000): 864–72. http://dx.doi.org/10.1116/1.582268.

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5

Ying, Hai, Jennifer Murphy, John W. Tromp, J. M. Mermet, and Eric D. Salin. "Warning diagnostics for inductively coupled plasma-mass spectrometry." Spectrochimica Acta Part B: Atomic Spectroscopy 55, no. 4 (April 2000): 311–26. http://dx.doi.org/10.1016/s0584-8547(00)00144-0.

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6

Lippi, Giuseppe, and Mario Plebani. "Integrated diagnostics." Biochemia medica 30, no. 1 (February 15, 2020): 18–30. http://dx.doi.org/10.11613/bm.2020.010501.

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The current scenario of in vitro and in vivo diagnostics can be summarized using the “silo metaphor”, where laboratory medicine, pathology and radiology are three conceptually separated diagnostic disciplines, which will increasingly share many comparable features. The substantial progresses in our understanding of biochemical-biological interplays that characterize many human diseases, coupled with extraordinary technical advances, are now generating important multidisciplinary convergences, leading the way to a new frontier, called integrated diagnostics. This new discipline, which is currently defined as convergence of imaging, pathology and laboratory tests with advanced information technology, has an enormous potential for revolutionizing diagnosis and therapeutic management of human diseases, including those causing the largest number of worldwide deaths (i.e. cardiovascular disease, cancer and infectious diseases). However, some important drawbacks should be overcome, mostly represented by insufficient information technology infrastructures, costs and enormous volume of different information that will be integrated and delivered. To overcome these hurdles, some specific strategies should be defined and implemented, such as planning major integration of exiting information systems or developing innovative ones, combining bioinformatics and imaging informatics, using health technology assessment for assessing cost and benefits, providing interpretative comments in integrated reports, developing and using expert systems and neural networks, overcoming cultural and political boundaries for generating multidisciplinary teams and integrated diagnostic algorithms.

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7

Nakano, Toshiki, Seiichi Takaira, Takeshi Kitajima, and Seiji Samukawa. "Optical Diagnostics of a Pulsed Inductively Coupled Nitrogen Plasma." IEEJ Transactions on Fundamentals and Materials 125, no. 1 (2005): 30–38. http://dx.doi.org/10.1541/ieejfms.125.30.

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8

Goree, J., Bin Liu, and Yan Feng. "Diagnostics for transport phenomena in strongly coupled dusty plasmas." Plasma Physics and Controlled Fusion 55, no. 12 (November 28, 2013): 124004. http://dx.doi.org/10.1088/0741-3335/55/12/124004.

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9

Downey, S. W., G. L. Keaton, and N. S. Nogar. "Spatially resolved, intracavity absorption for inductively coupled plasma diagnostics." Spectrochimica Acta Part B: Atomic Spectroscopy 40, no. 7 (January 1985): 927–32. http://dx.doi.org/10.1016/0584-8547(85)80063-x.

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10

Mayer, Michael, Leopold Haimberger, John M. Edwards, and Patrick Hyder. "Toward Consistent Diagnostics of the Coupled Atmosphere and Ocean Energy Budgets." Journal of Climate 30, no. 22 (November 2017): 9225–46. http://dx.doi.org/10.1175/jcli-d-17-0137.1.

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The widely used diagnostic vertically integrated total energy budget equations of atmosphere and ocean contain inconsistencies that should no longer be disregarded. The neglect of enthalpy fluxes associated with precipitation and evaporation leads to a spurious dependence on reference temperature. This seemingly small inconsistency is amplified because enthalpy of water vapor implicitly included in lateral atmospheric energy transports usually is computed on the Kelvin scale, leading to inconsistencies that, although zero when globally averaged, attain values on the order of 20 W m−2 in the tropics. A more consistent energy budget framework is presented, which is independent of reference temperature and which takes full account of enthalpy fluxes associated with mass transfer through the surface. The latter include effects of snowfall and additional nonlatent contributions, which have a net cooling effect on the earth’s surface (−1.3 W m−2). In addition to these diagnostic issues, comparatively small inconsistencies in the energetic formulations of current weather and climate models are highlighted. Using the energy budget formulation presented here, instead of that commonly used, yields enhanced self-consistency of diagnosed atmospheric energy budgets and substantially improved spatial agreement between fields of net surface energy flux inferred from the divergence of lateral atmospheric energy transports in conjunction with satellite-based radiative fluxes and independent surface flux products. Results imply that previous estimates of radiative plus turbulent surface fluxes over the ocean, balancing the observed ocean warming, are biased low by ~1.3 W m−2. Moreover, previous studies seriously underestimated cross-equatorial atmospheric and oceanic energy transports. Overall, the presented framework allows for unambiguous coupled energy budget diagnostics and yields more reliable benchmark values for validation purposes.

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11

Aadim, Kadhim A. "Diagnostics of low-pressure capacitively coupled RF discharge argon plasma." Iraqi Journal of Physics (IJP) 13, no. 27 (February 4, 2019): 76–82. http://dx.doi.org/10.30723/ijp.v13i27.266.

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Low-pressure capacitively coupled RF discharge Ar plasma has been studied using Langmuir probe. The electron temperature, electron density and Debay length were calculated under different pressures and electrode gap. In this work the RF Langmuir probe is designed using 4MHz filter as compensation circuit and I-V probe characteristic have been investigated. The pressure varied from 0.07 mbar to 0.1 mbar while electrode gap varied from 2-5 cm. The plasma was generated using power supply at 4MHz frequency with power 300 W. The flowmeter is used to control Argon gas flow in the range of 600 standard cubic centimeters per minute (sccm). The electron temperature drops slowly with pressure and it's gradually decreased when expanding the electrode gap. As the gas pressure increases, the plasma density rises slightly at low gas pressure while it drops little at higher gas pressure. The electron density decreases rapidly with expand distances between electrodes.

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12

Okigawa, Akifumi, Zoran Lj.Petrović, Masahiro Tadokoro, Toshiaki Makabe, Nobuhiko Nakano, and Akihiko Itoh. "Diagnostics of a non‐equilibrium inductively coupled plasmas in argon." Applied Physics Letters 69, no. 18 (October 28, 1996): 2644–46. http://dx.doi.org/10.1063/1.117545.

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13

Hsu, Paul S., Daniel Lauriola, Naibo Jiang, Joseph D. Miller, James R. Gord, and Sukesh Roy. "Fiber-coupled, UV–SWIR hyperspectral imaging sensor for combustion diagnostics." Applied Optics 56, no. 21 (July 19, 2017): 6029. http://dx.doi.org/10.1364/ao.56.006029.

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14

Janssen, Curtis L., and Ida M. B. Nielsen. "New diagnostics for coupled-cluster and Møller–Plesset perturbation theory." Chemical Physics Letters 290, no. 4-6 (July 1998): 423–30. http://dx.doi.org/10.1016/s0009-2614(98)00504-1.

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15

Makarov, Nikolay S., Karthik Ramasamy, Aaron Jackson, Andres Velarde, Chloe Castaneda, Nic Archuleta, Damon Hebert, Matthew R. Bergren, and Hunter McDaniel. "Fiber-Coupled Luminescent Concentrators for Medical Diagnostics, Agriculture, and Telecommunications." ACS Nano 13, no. 8 (July 10, 2019): 9112–21. http://dx.doi.org/10.1021/acsnano.9b03335.

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16

Sakata, Toshiya. "Biologically Coupled Gate Field-Effect Transistors Meet in Vitro Diagnostics." ACS Omega 4, no. 7 (July 9, 2019): 11852–62. http://dx.doi.org/10.1021/acsomega.9b01629.

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17

Uotila, Petteri, David M. Holland, Miguel A. Morales Maqueda, Sirpa Häkkinen, Greg Holloway, Michael Karcher, Frank Kauker, et al. "An energy-diagnostics intercomparison of coupled ice-ocean Arctic models." Ocean Modelling 11, no. 1-2 (January 2006): 1–27. http://dx.doi.org/10.1016/j.ocemod.2004.11.003.

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18

Matsutani, Akihiro, Hideo Ohtsuki, Fumio Koyama, and Kenichi Iga. "Plasma Diagnostics in Inductively Coupled Plasma Etching Using Cl2/Xe." Japanese Journal of Applied Physics 39, Part 1, No. 3A (March 15, 2000): 1435–36. http://dx.doi.org/10.1143/jjap.39.1435.

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19

Xin Yu, Di Xiao-Lian, Yu Yi-Qing, and Ning Zhao-Yuan. "Generation of multi-source inductively coupled plasma and its diagnostics." Acta Physica Sinica 55, no. 7 (2006): 3494. http://dx.doi.org/10.7498/aps.55.3494.

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20

Reich, R. K., W. M. McGonagle, J. A. Gregory, R. W. Mountain, B. B. Kosicki, and E. D. Savoye. "High performance charge-coupled-device imager technology for plasma diagnostics." Review of Scientific Instruments 68, no. 1 (January 1997): 922–25. http://dx.doi.org/10.1063/1.1147770.

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21

Loccisano, Frank, Sachin Joshi, Isaiah S. Franka, Zhiyao Yin, Walter R. Lempert, and Azer P. Yalin. "Fiber-coupled ultraviolet planar laser-induced fluorescence for combustion diagnostics." Applied Optics 51, no. 27 (September 20, 2012): 6691. http://dx.doi.org/10.1364/ao.51.006691.

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22

Creatore, Mariadriana, Fabio Palumbo, and Riccardo d'Agostino. "Diagnostics and insights on PECVD for gas-barrier coatings." Pure and Applied Chemistry 74, no. 3 (January 1, 2002): 407–11. http://dx.doi.org/10.1351/pac200274030407.

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In this work, we report on our last results concerning the polyethyleneterephtalate barrier performance optimization as a function of the chemistry of the SiOx coating, deposited by means of hexamethyldisiloxane/oxygen-fed plasmas ignited in an RF capacitively coupled parallel plates reactor. The influence of the gas feed composition and power on the plasma phase/coating chemistry and on the O2 gas transmission rate has been investigated. The plasma phase has been studied by means of Fourier transform infrared absorption (FT-IR) and optical emission spectroscopies (OES), and the results have been coupled to the film chemistry investigated by means of FT-IR spectroscopy. These techniques show excellent potentialities in the correlation of the plasma phase and film chemistries with the barrier properties of the SiOx-coated polymer, especially when a very good barrier level is required.

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23

O’Rourke, Amanda K., Brian K. Arbic, and Stephen M. Griffies. "Frequency-Domain Analysis of Atmospherically Forced versus Intrinsic Ocean Surface Kinetic Energy Variability in GFDL’s CM2-O Model Hierarchy." Journal of Climate 31, no. 5 (March 2018): 1789–810. http://dx.doi.org/10.1175/jcli-d-17-0024.1.

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Low-frequency variability at the ocean surface can be excited both by atmospheric forcing, such as in exchanges of heat and momentum, and by the intrinsic nonlinear transfer of energy between mesoscale ocean eddies. Recent studies have shown that nonlinear eddy interactions can excite an energy transfer from high to low frequencies analogous to the transfer of energy from high to low wavenumbers (small to large spatial scales) in quasi-two-dimensional turbulence. As the spatial inverse cascade is driven by oceanic eddies, the process of energy exchange across frequencies may be sensitive to ocean model resolution. Here a cross-spectrum diagnostic is applied to the oceanic component in a hierarchy of fully coupled ocean–atmosphere models to address the transfer of ocean surface kinetic energy between high and low frequencies. The cross-spectral diagnostic allows for a comparison of the relative contributions of coupled atmospheric forcing through wind stress and the intrinsic advection to low-frequency ocean surface kinetic energy. Diagnostics of energy flux and transfer within the frequency domain are compared between three coupled models with ocean model horizontal resolutions of 1°, 1/4°, and 1/10° to address the importance of resolving eddies in the driving of energy to low frequencies in coupled models.

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24

Fraenkel, M., Y. Ehrlich, D. Rubin, Y. Ferber, and G. Sturm. "Laser produced soft x-ray source diagnostics with temporal, spectral, and spatial resolution." Review of Scientific Instruments 93, no. 7 (July 1, 2022): 073509. http://dx.doi.org/10.1063/5.0098780.

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We demonstrate the use of three diagnostic tools which simultaneously view the target from nearly the same direction, and their results are combined to provide temporally, spectrally, and spatially resolved absolutely calibrated target emission information. To demonstrate this capability, Au targets were irradiated by 1.8 kJ, 3 ns laser pulses to produce broadband soft x-ray emission in the 0.1–3.5 keV spectral range. Target diagnostics included a time-resolved x-ray diode array, each measured a partial spectral band, time-integrated spectrally resolved absolutely calibrated transmission grating spectrometer, and static and time-resolved soft x-ray imagers coupled to a charge-coupled device camera and to a streak camera, respectively, measuring spatially and temporally resolved radiation at the main Au target emission bands. The combined temporally, spectrally, and spatially resolved absolutely calibrated target emission result can be compared to simulations and be used to design and analyze experiments in which the source emission is used as a drive for various physical processes.

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25

Singer, Donald RJ, and John Watkins. "Using companion and coupled diagnostics within strategy to personalize targeted medicines." Personalized Medicine 9, no. 7 (September 2012): 751–61. http://dx.doi.org/10.2217/pme.12.86.

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26

Carré, Martine, Emmanuelle Poussel, and Jean-Michel Mermet. "Drift diagnostics in inductively coupled plasma atomic emission spectrometry. Plenary lecture." J. Anal. At. Spectrom. 7, no. 6 (1992): 791–97. http://dx.doi.org/10.1039/ja9920700791.

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27

Bol’shakov, A. A., and B. A. Cruden. "Diagnostics of the inductively coupled plasma by diode laser absorption spectroscopy." Technical Physics 53, no. 11 (November 2008): 1423–32. http://dx.doi.org/10.1134/s1063784208110054.

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28

Malaquias, A., A. E. Costley, K. Ebisawa, G. Janeschitz, G. Vayakis, C. Walker, and S. Yamamoto. "Integration of direct-coupled diagnostics into ITER equatorial and upper ports." Fusion Engineering and Design 56-57 (October 2001): 889–93. http://dx.doi.org/10.1016/s0920-3796(01)00372-6.

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29

Sugai, H., K. Nakamura, Y. Hikosaka, and M. Nakamura. "Diagnostics and control of radicals in an inductively coupled etching reactor." Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films 13, no. 3 (May 1995): 887–93. http://dx.doi.org/10.1116/1.579847.

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30

Bleck, Rainer, and Shan Sun. "Diagnostics of the oceanic thermohaline circulation in a coupled climate model." Global and Planetary Change 40, no. 3-4 (February 2004): 233–48. http://dx.doi.org/10.1016/j.gloplacha.2003.04.002.

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31

Odion, Ren A., Yang Liu, and Tuan Vo-Dinh. "Nanoplasmonics Enabling Cancer Diagnostics and Therapy." Cancers 14, no. 23 (November 22, 2022): 5737. http://dx.doi.org/10.3390/cancers14235737.

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In this paper, we highlight several advances our laboratory has developed in the pursuit of cancer diagnostics and therapeutics by integrating plasmonics, photonics, and nanotechnology. We discuss the development and applications of plasmonics-active gold nanostar (GNS), a uniquely shaped nanoparticle with numerous branches that serve to greatly amplify the thermal generation at resonant wavelengths. GNS has also been successfully used in tumor imaging contexts from two-photon fluorescence to surface-enhanced Raman scattering (SERS) sensing and imaging. Finally, GNS has been coupled with immunotherapy applications to serve as an effective adjuvant to immune checkpoint inhibitors. This combination of GNS and immunotherapy, the so called synergistic immuno photo nanotherapy (SYMPHONY), has been shown to be effective at controlling long-lasting cancer immunity and metastatic tumors.

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32

Knowlton, Stephanie, Ashwini Joshi, Philip Syrrist, Ahmet F. Coskun, and Savas Tasoglu. "3D-printed smartphone-based point of care tool for fluorescence- and magnetophoresis-based cytometry." Lab on a Chip 17, no. 16 (2017): 2839–51. http://dx.doi.org/10.1039/c7lc00706j.

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33

Muszynska, Agnes. "Vibrational Diagnostics of Rotating Machinery Malfunctions." International Journal of Rotating Machinery 1, no. 3-4 (1995): 237–66. http://dx.doi.org/10.1155/s1023621x95000108.

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This paper outlines rotating machinery malfunction diagnostics using vibration data in correlation with operational process data. The advantages of vibration monitoring systems as a part of preventive/predictive maintenance programs are emphasized. After presenting basic principles of machinery diagnostics, several specific malfunction symptoms supported by simple mathematical models are given. These malfunctions include unbalance, excessive radial load, rotor-to-stator rubbing, fluid-induced vibrations, loose stationary and rotating parts, coupled torsional/lateral vibration excitation, and rotor cracking. The experimental results and actual field data illustrate the rotor vibration responses for individual malfunctions. Application of synchronous and nonsynchronous perturbation testing used for identification of basic dynamic characteristics of rotors is presented. Future advancements in vibration monitoring and diagnostics of rotating machinery health are discussed. In the Appendix, basic instrumentation for machine monitoring is outlined.

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34

LIU, WEI-ZHONG, and DAO-JUN LIU. "STATEFINDER DIAGNOSTIC FOR QUINTESSENCE WITH OR WITHOUT THERMAL INTERACTION." International Journal of Modern Physics D 18, no. 01 (January 2009): 43–52. http://dx.doi.org/10.1142/s0218271809014261.

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The cosmological dynamics of a minimally coupled scalar field that couples to the background matter with thermal interactions is investigated using statefinder diagnostics. The time evolution of the statefinder pairs {r, s} and {r, q} are obtained under the circumstance that different values of model parameters are chosen. We show that the thermal coupling term does not affect the location of the late-time attractor, but exerts an influence on the evolution of the statefinder parameters. The most notable feature of the r–s plane for the thermal coupling model, which is distinguished from the other dark energy models, is that some part of the curve with thermal coupling can form a closed loop in the second quadrant (r > 1, s < 0).

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35

Kuanaeva, Regina M., Alexander N. Vaneev, Petr V. Gorelkin, and Alexander S. Erofeev. "Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules." Biosensors 14, no. 12 (December 19, 2024): 627. https://doi.org/10.3390/bios14120627.

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Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection of biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, and multifunctionality. The features have significantly expanded interest in their applications for the biomolecular detection, imaging, and molecular diagnostics of real samples. Moreover, the ease of manufacturing nanopipettes, coupled with their compatibility with fluorescence and electrochemical methods, makes them ideal for portable point-of-care diagnostic devices. This review summarized the latest progress in nanopipette-based nanopore technology for the detection of biomarkers, DNA, RNA, proteins, and peptides, in particular β-amyloid or α-synuclein, emphasizing the impact of technology on molecular diagnostics. By addressing key challenges in single-molecule detection and expanding applications in diverse biological areas, nanopipettes are poised to play a transformative role in the future of personalized medicine.

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36

Shaidukova, L. K. "А systemic apprоaсh to alcoholism among married couples." Neurology Bulletin XXXII, no. 1-2 (May 15, 2000): 35–39. http://dx.doi.org/10.17816/nb77768.

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129 alcoholic wоmen were observed from families witl1 alcoholic addiction. Study of social and psychologic factors, ensuring formation of paired, coupled alcoholism showed the importance of choosing а marital partner. Some main reasons of choosing by а women а partner with alcoholic habits were given: 1) more frequent alcohol consumption, less resistance to alcohol; 2) their belonginess to alcoholic environment; 3) as а result of formed stereotype of marital behavior; 4) in accordance with similar character features. These peculiarities are to be taken into consideration in accomplishing medical and psychologic activities for early diagnostics of alcoholic couples.

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37

Liu, Guangxing, Hua Chai, Yuguo Tang, and Peng Miao. "Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction." Chemical Communications 56, no. 8 (2020): 1175–78. http://dx.doi.org/10.1039/c9cc08753b.

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38

Boffard, John B., R. O. Jung, Chun C. Lin, L. E. Aneskavich, and A. E. Wendt. "Optical diagnostics for characterization of electron energy distributions: argon inductively coupled plasmas." Plasma Sources Science and Technology 20, no. 5 (August 16, 2011): 055006. http://dx.doi.org/10.1088/0963-0252/20/5/055006.

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39

Minayeva, Olga B., and Jeffrey Hopwood. "Langmuir probe diagnostics of a microfabricated inductively coupled plasma on a chip." Journal of Applied Physics 94, no. 5 (September 2003): 2821–28. http://dx.doi.org/10.1063/1.1597976.

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40

Xu, Lin, Lee Chen, Merritt Funk, Alok Ranjan, Mike Hummel, Ron Bravenec, Radha Sundararajan, Demetre J. Economou, and Vincent M. Donnelly. "Diagnostics of ballistic electrons in a dc/rf hybrid capacitively coupled discharge." Applied Physics Letters 93, no. 26 (December 29, 2008): 261502. http://dx.doi.org/10.1063/1.3062853.

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41

Daltrini, Andre M., Stanislav A. Moshkalev, Thomas Morgan, Robert Piejak, and William Graham. "Plasma Diagnostics in an Inductively Coupled Plasma - Gaseous Electronics Conference Reference Cell." ECS Transactions 14, no. 1 (December 18, 2019): 365–73. http://dx.doi.org/10.1149/1.2956051.

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42

Messerer, P., B. Boenigk, G. Keil, P. Scheubert, and P. Awakowicz. "Plasma diagnostics in a double inductively coupled source (DICP) for plasma sterilisation." Surface and Coatings Technology 174-175 (September 2003): 570–73. http://dx.doi.org/10.1016/s0257-8972(03)00630-3.

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43

Nielsen, Ida M. Beck, and Curtis L. Janssen. "Double-substitution-based diagnostics for coupled-cluster and Møller–Plesset perturbation theory." Chemical Physics Letters 310, no. 5-6 (September 1999): 568–76. http://dx.doi.org/10.1016/s0009-2614(99)00770-8.

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44

Malyshev, M. V., N. C. M. Fuller, K. H. A. Bogart, V. M. Donnelly, and Irving P. Herman. "Diagnostics of inductively coupled chlorine plasmas: Measurement of Cl2+ and Cl+ densities." Journal of Applied Physics 88, no. 5 (September 2000): 2246–51. http://dx.doi.org/10.1063/1.1288156.

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45

O'Brien Murdock, Su-Ann E., Kaveh Kahen, Jos� R. Chirinos, Michael E. Ketterer, David D. Hudson, and Akbar Montaser. "Aerosol diagnostics and inductively coupled plasma mass spectrometry with demountable concentric nebulizers." Journal of Analytical Atomic Spectrometry 19, no. 5 (2004): 666. http://dx.doi.org/10.1039/b309826p.

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46

Donnelly, V. M., and M. V. Malyshev. "Diagnostics of inductively coupled chlorine plasmas: Measurements of the neutral gas temperature." Applied Physics Letters 77, no. 16 (October 16, 2000): 2467–69. http://dx.doi.org/10.1063/1.1318727.

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47

Liberto, Juliane M., Sheng-Yin Chen, Ie-Ming Shih, Tza-Huei Wang, Tian-Li Wang, and Thomas R. Pisanic. "Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review." Cancers 14, no. 12 (June 11, 2022): 2885. http://dx.doi.org/10.3390/cancers14122885.

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With a 5-year survival rate of less than 50%, ovarian high-grade serous carcinoma (HGSC) is one of the most highly aggressive gynecological malignancies affecting women today. The high mortality rate of HGSC is largely attributable to delays in diagnosis, as most patients remain undiagnosed until the late stages of -disease. There are currently no recommended screening tests for ovarian cancer and there thus remains an urgent need for new diagnostic methods, particularly those that can detect the disease at early stages when clinical intervention remains effective. While diagnostics for ovarian cancer share many of the same technical hurdles as for other cancer types, the low prevalence of the disease in the general population, coupled with a notable lack of sensitive and specific biomarkers, have made the development of a clinically useful screening strategy particularly challenging. Here, we present a detailed review of the overall landscape of ovarian cancer diagnostics, with emphasis on emerging methods that employ novel protein, genetic, epigenetic and imaging-based biomarkers and/or advanced diagnostic technologies for the noninvasive detection of HGSC, particularly in women at high risk due to germline mutations such as BRCA1/2. Lastly, we discuss the translational potential of these approaches for achieving a clinically implementable solution for screening and diagnostics of early-stage ovarian cancer as a means of ultimately improving patient outcomes in both the general and high-risk populations.

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48

Barría, Daniela, and Stefan Kimeswenger. "Analysis of Multiple Shell Planetary Nebulae Based on HST/WFPC2 Extended 2D Diagnostic Diagrams." Galaxies 6, no. 3 (August 3, 2018): 84. http://dx.doi.org/10.3390/galaxies6030084.

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The investigation of gaseous nebulae, emitting in forbidden lines, is often based extensively on diagnostic diagrams. The special physics of these lines often allows for disentangling with a few line ratios normally coupled thermodynamic parameters like electron temperature, density and properties of the photo-ionizing radiation field. Diagnostic diagrams are usually used for the investigation of planetary nebulae as a total. We investigated the extension of such integrated properties towards spatially resolved 2D diagnostics, using Hubble Space Telescope/Wide Field Planetary Camera 2 (HST/WFPC2) narrow band images. For this purpose, we also derived a method to isolate pure Hα emission from the [N ii] contamination as normally suffering in the F656N HST/WFPC2 filter.

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Eyring, Veronika, Lisa Bock, Axel Lauer, Mattia Righi, Manuel Schlund, Bouwe Andela, Enrico Arnone, et al. "Earth System Model Evaluation Tool (ESMValTool) v2.0 – an extended set of large-scale diagnostics for quasi-operational and comprehensive evaluation of Earth system models in CMIP." Geoscientific Model Development 13, no. 7 (July 30, 2020): 3383–438. http://dx.doi.org/10.5194/gmd-13-3383-2020.

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Abstract. The Earth System Model Evaluation Tool (ESMValTool) is a community diagnostics and performance metrics tool designed to improve comprehensive and routine evaluation of Earth system models (ESMs) participating in the Coupled Model Intercomparison Project (CMIP). It has undergone rapid development since the first release in 2016 and is now a well-tested tool that provides end-to-end provenance tracking to ensure reproducibility. It consists of (1) an easy-to-install, well-documented Python package providing the core functionalities (ESMValCore) that performs common preprocessing operations and (2) a diagnostic part that includes tailored diagnostics and performance metrics for specific scientific applications. Here we describe large-scale diagnostics of the second major release of the tool that supports the evaluation of ESMs participating in CMIP Phase 6 (CMIP6). ESMValTool v2.0 includes a large collection of diagnostics and performance metrics for atmospheric, oceanic, and terrestrial variables for the mean state, trends, and variability. ESMValTool v2.0 also successfully reproduces figures from the evaluation and projections chapters of the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5) and incorporates updates from targeted analysis packages, such as the NCAR Climate Variability Diagnostics Package for the evaluation of modes of variability, the Thermodynamic Diagnostic Tool (TheDiaTo) to evaluate the energetics of the climate system, as well as parts of AutoAssess that contains a mix of top–down performance metrics. The tool has been fully integrated into the Earth System Grid Federation (ESGF) infrastructure at the Deutsches Klimarechenzentrum (DKRZ) to provide evaluation results from CMIP6 model simulations shortly after the output is published to the CMIP archive. A result browser has been implemented that enables advanced monitoring of the evaluation results by a broad user community at much faster timescales than what was possible in CMIP5.

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Poonoosamy, Jenna, Cyprien Soulaine, Alina Burmeister, Guido Deissmann, Dirk Bosbach, and Sophie Roman. "Microfluidic flow-through reactor and 3D Raman imaging for in situ assessment of mineral reactivity in porous and fractured porous media." Lab on a Chip 20, no. 14 (2020): 2562–71. http://dx.doi.org/10.1039/d0lc00360c.

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Microfluidics flow-through reactor combined with in-situ, non-destructive Raman measurement for a spatio-temporal visualisation of the mineralogical changes in porous media. Advance pore scale modelling diagnostics of the coupled hydro-geochemical processes.

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