Relevant bibliographies by topics / Cortisol

Academic literature on the topic 'Cortisol'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 May 2024

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Journal articles on the topic "Cortisol"

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Debono, Miguel, Robert F. Harrison, Martin J. Whitaker, David Eckland, Wiebke Arlt, Brian G. Keevil, and Richard J. Ross. "Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone." Journal of Clinical Endocrinology & Metabolism 101, no. 4 (April 1, 2016): 1469–77. http://dx.doi.org/10.1210/jc.2015-3694.

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Abstract Context: Measuring serum cortisol to evaluate stress, adrenal disease, and monitor hydrocortisone replacement requires venepuncture. Conversely, salivary measurements are noninvasive. Objective: This study aimed to investigate measurement of salivary cortisol and cortisone as alternatives to serum cortisol. Design and Setting: This was a prospective cross-over study in a clinical research facility. Patients and Methods: Over three periods (Period 1, 24-h physiological cortisol rhythm; Periods 2 and 3, after 20 mg oral and iv hydrocortisone) 14 male volunteers had serum and saliva cortisol and cortisone, serum albumin, cortisol-binding globulin, and free cortisol measured. Data were analyzed for rhythm parameters and correlations. Linear mixed-effects modelling was performed to determine the relationship between serum cortisol and salivary cortisone. Results: Serum cortisol and cortisone showed similar circadian rhythms with large peak:trough ratios (cortisol median ratio, 11). Albumin and cortisol-binding globulin showed minor peak:trough ratios <1.2. When serum cortisol was <74 (SD, 29) nmol/L, salivary cortisol was not detectable but salivary cortisone was always detected. Salivary cortisol post-oral hydrocortisone produced spurious results due to contamination. Under physiological conditions, salivary cortisone correlated strongly with serum cortisol (ρ, 0.91; 95% confidence interval, 0.89–0.93; P < .001). Similarly, following iv or oral hydrocortisone, salivary cortisone correlated strongly with serum cortisol (ρ, 0.91; 95% confidence interval, 0.89–0.92; P < .001). A mixed-effects model showed that in this population 94% of the variation in salivary cortisone could be predicted from serum cortisol. Conclusion: Salivary cortisol is frequently undetectable and contaminated by oral hydrocortisone. In contrast, salivary cortisone reflects serum cortisol and provides a noninvasive alternative to measuring serum cortisol levels.
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Meulenberg, P. M., and J. A. Hofman. "Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum." Clinical Chemistry 36, no. 1 (January 1, 1990): 70–75. http://dx.doi.org/10.1093/clinchem/36.1.70.

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Abstract We measured cortisol and cortisone in plasma--both total and free--and in saliva during the course of pregnancy and postpartum. Antepartum and postpartum concentrations and morning and afternoon concentrations of both steroids were compared. The mean concentrations of cortisol and cortisone increased towards term and were significantly greater at the end of pregnancy than postpartum, except for free cortisol in plasma in the afternoon. The daily rhythm of both steroids was maintained throughout pregnancy and postpartum. The correlations between salivary and plasma free concentrations of cortisol and cortisone as well as of the sum of cortisol + cortisone were highly significant. The mean concentrations of cortisone in saliva accurately reflected both total and free concentrations in plasma. For cortisol, however, the change of the concentrations in saliva, was somewhat different from that in plasma. Moreover, the mass ratio of plasma free cortisol to salivary cortisol was about 2, whereas for cortisone the ratio was only about 0.5, probably owing to the conversion of cortisol to cortisone by 11 beta-hydroxysteroid dehydrogenase in the salivary gland. Furthermore, the passage of cortisol and cortisone from plasma to saliva should not be regarded as simple diffusion, because in the first half of pregnancy the sum of the concentrations of cortisol + cortisone in saliva significantly exceeded the sum of their free concentrations in plasma.
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Žaja, Roko, Sanja Stipičević, Milan Milošević, Andro Košec, Jakov Ajduk, Iva Kelava, Adrijana Zglavnik Baća, Marko Klarica, and Mihael Ries. "Salivary cortisone as potential predictor of occupational exposure to noise and related stress." Archives of Industrial Hygiene and Toxicology 74, no. 4 (December 1, 2023): 232–37. http://dx.doi.org/10.2478/aiht-2023-74-3785.

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Abstract Salivary cortisone strongly correlates with serum cortisol, and since it is less invasive to measure salivary cortisone than serum cortisol and easier than to measure cortisol in saliva, as its concentrations are much lower, we wanted to compare salivary cortisone and cortisol levels as markers of noise-induced stress reaction. The study included 104 participants aged 19–30 years, 50 of whom were exposed to occupational noise ≥85 dB(A) and 54 non-exposed, control students. All participants took samples of their saliva with Salivette® Cortisol synthetic swabs on three consecutive working days first thing in the morning. Salivary cortisone and cortisol levels were determined with high-performance liquid chromatography. In addition, they completed a 10-item Perceived Stress Scale (PSS-10) questionnaire, and occupationally noise-exposed participants also completed the Health and Safety Executive (HSE) questionnaire on occupational psychosocial risks. The exposed participants had significantly higher cortisone (P<0.001) and cortisol (P<0.001) levels than controls, and the correlation between cortisone and cortisol levels in the exposed participants was strong (ϱ =0.692, P<0.001), which suggests that salivary cortisone can replace cortisol measurements in saliva as a more reliable method than salivary cortisol and less invasive than serum cortisol. However, the level of perceived stress scored on PSS-10 in the exposed participants did not differ significantly from stress reported by controls, but correlated negatively with cortisone levels, which is contrary to our expectations and raises questions as to why.
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Colling, Caitlin, Miriam Bredella, Pouneh Fazeli, Gisela Pachón-Peña, Ravinder Singh, Anne Klibanski, Clifford Rosen, and Karen Miller. "ODP053 Serum Free Cortisol and Free Cortisol-to-Cortisone Ratio Increase After 10 Days of Overfeeding and After 10 Days of Fasting." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A64—A65. http://dx.doi.org/10.1210/jendso/bvac150.132.

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Abstract Introduction Chronic caloric deprivation and obesity are complicated by elevations of serum total cortisol levels. The effects of acute overfeeding and fasting on circulating free cortisol levels and interconversion of cortisone to free cortisol are unknown. We hypothesized that serum free cortisol and free cortisol-to-cortisone ratio (a surrogate measure of 11β-hydroxysteroid dehydrogenase [11β-HSD] activity) would increase after both overfeeding and fasting. Methods We prospectively studied 22 healthy volunteers who underwent a 10-day high-calorie protocol followed by a 10-day fast, separated by a 2-week wash-out period, in a Clinical Research Center. Fasting morning free and total cortisol and free cortisone levels (liquid chromatography-tandem mass spectrometry, Mayo Labs) and percent body fat (dual-energy x-ray absorptiometry) were performed at baseline before and after 10 days of each intervention. Results High-calorie feeding increased total and free cortisol and the free cortisol-to-free cortisone ratio (p&lt;0. 001 to p=0. 046). Total and free cortisol, the free cortisol-to-free cortisone ratio, and the free cortisol-to-total cortisol ratio increased after fasting (p=0. 001 to 0. 021). During the high-calorie protocol, there was no significant interaction between sex and time for any of the cortisol parameters. During the fasting visit, the changes in free cortisol and free-to-total cortisol ratio were modified by sex (p=0. 014 and 0. 004, respectively for interaction term), with a trend toward a significant interaction between sex and time in the change in free cortisol-to-free cortisone ratio (p=0. 054). In subset analyses stratified by sex examining the effect of fasting on free cortisol and the free-to-total cortisol ratio, there were significant increases in men (p&lt;0. 001) but not women (p=0.898 and 1. 000, respectively). Baseline percent body fat, measured at the start of the fasting visit, was inversely associated with change in free cortisol (ρ=-0.52, p=0. 013), free cortisol-to-total cortisol ratio (ρ=-0.49, p=0. 021) and free cortisol-to-cortisone ratio (ρ=-0.47, p=0. 029) during fasting. Conclusion Overfeeding and fasting both increase circulating free cortisol levels and appear to alter 11β-HSD activity. The effect of fasting, but not overfeeding, on free cortisol levels is modified by sex. Greater percent fat mass may be relatively protective against starvation-induced hypercortisolemia in women. Further study is warranted to determine whether elevated cortisol levels contribute to complications of starvation and obesity, such as bone fragility. Presentation: No date and time listed
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Harrison, Robert F., Miguel Debono, Martin J. Whitaker, Brian G. Keevil, John Newell-Price, and Richard J. Ross. "Salivary Cortisone to Estimate Cortisol Exposure and Sampling Frequency Required Based on Serum Cortisol Measurements." Journal of Clinical Endocrinology & Metabolism 104, no. 3 (October 3, 2018): 765–72. http://dx.doi.org/10.1210/jc.2018-01172.

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Abstract Context Population studies frequently measure cortisol as a marker of stress, and excess cortisol is associated with increased mortality. Cortisol has a circadian rhythm, and frequent blood sampling is impractical to assess cortisol exposure. We investigated measuring salivary cortisone and examined the sampling frequency required to determine cortisol exposure. Methods Serum and saliva with cortisol and cortisone were measured by liquid chromatography–tandem mass spectrometry in independent cohorts. The relationship between serum cortisol and salivary cortisone was analyzed in cohort 1 using a linear mixed effects model. The resulting fixed effects component was applied to cohort 2. Saliva cannot easily be collected when a patient is sleeping, so we determined the minimum sampling required to estimate cortisol exposure [estimated area under the curve (eAUC)] using 24-hour cortisol profiles (AUC24) and calculated the relative error (RE) for eAUC. Results More than 90% of variability in salivary cortisone could be accounted for by change in serum cortisol. A single serum cortisol measurement was a poor estimate of AUC24, especially in the morning or last thing at night (RE &gt;68%); however, three equally spaced samples gave a median RE of 0% (interquartile range, −15.6% to 15.1%). In patients with adrenal incidentalomas, eAUC based on three serum cortisol samples showed a difference between those with autonomous cortisol secretion and those without (P = 0.03). Interpretation Accepting that most people sleep 7 to 8 hours, ∼8-hourly salivary cortisone measurements provide a noninvasive method of estimating 24-hour cortisol exposure for population studies.
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Quilez, Ester, Richard K. Burchell, Eric B. Thorstensen, Karin Weidgraaf, Stacey E. Parbhu, Nicolas Lopez-Villalobos, and Arnon Gal. "Cortisol urinary metabolites in dogs with hypercortisolism, congestive heart failure, and healthy dogs: pilot investigation." Journal of Veterinary Diagnostic Investigation 32, no. 2 (January 10, 2020): 317–23. http://dx.doi.org/10.1177/1040638719899645.

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Nonadrenal diseases (NAD), including congestive heart failure (CHF), can affect the conversion of cortisone to cortisol favoring the production of cortisol’s urinary downstream metabolites 5α/5β-tetrahydrocortisol (THF) relative to tetrahydrocortisone (THE). We hypothesized that healthy dogs would have lower urinary levels of cortisol, cortisone, THF, and THE than dogs with hypercortisolism (HC) or CHF, and the latter would have higher urinary levels of THF and lower THE than dogs with HC. Four, 9, and 8 dogs with HC, CHF, and normal health, respectively, were included in a pilot prospective cross-sectional study. A single morning voided urine sample was analyzed for urinary cortisol metabolites by liquid chromatography–mass spectrometry. The percentages of conjugated urinary metabolites were significantly higher in dogs with CHF than in healthy dogs ( p = 0.001), and not different in HC dogs ( p = 0.07). Log-transformed urine cortisol metabolites–to–creatinine ratios in healthy dogs were significantly lower than the 2 other groups ( p < 0.001). The urinary free THE:THF ratio was significantly higher ( p < 0.001) than the urinary total and conjugated THE:THF ratios. Health status did not affect the total, conjugated, and free THE:THF ratios ( p = 0.61). Additional studies are needed to investigate differences in cortisol metabolites between dogs with HC and NAD to accurately discriminate between the groups.
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Raff, Hershel, and James W. Findling. "Salivary cortisol or cortisone?" Nature Reviews Endocrinology 6, no. 12 (November 23, 2010): 658–60. http://dx.doi.org/10.1038/nrendo.2010.192.

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Nomura, Shinji, Michiko Fujitaka, Nobuo Sakura, and Kazuhiro Ueda. "Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio." Clinica Chimica Acta 266, no. 2 (October 1997): 83–91. http://dx.doi.org/10.1016/s0009-8981(97)00142-3.

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Sigurjonsdottir, Helga A., Ruth Andrew, Roland H. Stimson, Gudmundur Johannsson, and Brian R. Walker. "Lack of regulation of 11β-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism." European Journal of Endocrinology 161, no. 3 (September 2009): 375–80. http://dx.doi.org/10.1530/eje-09-0315.

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ObjectiveEvidence from long-term clinical studies measuring urinary steroid ratios, and from in vitro studies, suggests that GH administered for longer than 2 months down-regulates 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby reducing cortisol regeneration in liver and adipose tissue. We aimed to measure acute effects of GH on 11β-HSD1 in liver and adipose tissue in vivo, including using a stable isotope tracer.DesignObservational studies of GH withdrawal and reintroduction in patients with hypopituitarism.MethodsTwelve men with benign pituitary disease causing GH and ACTH deficiency on stable replacement therapy for >6 months were studied after GH withdrawal for 3 weeks, and after either placebo or GH injections were reintroduced for another 3 weeks. We measured cortisol kinetics during 9,11,12,12-2H4-cortisol (d4-cortisol) infusion, urinary cortisol/cortisone metabolite ratios, liver 11β-HSD1 by appearance of plasma cortisol after oral cortisone, and 11β-HSD1 mRNA levels in subcutaneous adipose biopsies.ResultsGH withdrawal and reintroduction had no effect on 9,12,12-[2H]3-cortisol (d3-cortisol) appearance, urinary cortisol/cortisone metabolite ratios, initial appearance of cortisol after oral cortisone, or adipose 11β-HSD1 mRNA. GH withdrawal increased plasma cortisol 30–180 min after oral cortisone, increased d4-cortisol clearance, and decreased relative excretion of 5α-reduced cortisol metabolites.ConclusionsIn this setting, GH did not regulate 11β-HSD1 rapidly in vivo in humans. Altered cortisol metabolism with longer term changes in GH may reflect indirect effects on 11β-HSD1. These data do not suggest that glucocorticoid replacement doses need to be increased immediately after introducing GH therapy to compensate for reduced 11β-HSD1 activity, although dose adjustment may be required in the longer term.
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Kalaria, Tejas, Mayuri Agarwal, Sukhbir Kaur, Lauren Hughes, Hayley Sharrod-Cole, Rahul Chaudhari, Carolina Gherman-Ciolac, et al. "Hypothalamic–pituitary–adrenal axis suppression – The value of salivary cortisol and cortisone in assessing hypothalamic–pituitary–adrenal recovery." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 6 (October 13, 2020): 456–60. http://dx.doi.org/10.1177/0004563220961745.

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Background The 0.25 mg short synacthen test is used to assess recovery from hypothalamic–pituitary–adrenal suppression due to chronic glucocorticoid administration. We assessed the potential role of salivary cortisol and cortisone in predicting hypothalamic–pituitary–adrenal function using the short synacthen test as the gold standard test. Method Between 09:00 and 10:30, salivary and blood samples were collected just prior to a short synacthen test to assess hypothalamic–pituitary–adrenal axis recovery in patients previously treated with oral glucocorticoids. The cut-off for a normal short synacthen test was a 30-min cortisol ≥450 nmol/L. Results Fifty-six short synacthen tests were performed on 47 patients. Of these, 15 were normal. The area under receiver operating characteristic curves for serum cortisol, salivary cortisone and salivary cortisol were 0.772, 0.785 and 0.770, respectively. From the receiver operating characteristic analysis, the cut-offs for baseline serum cortisol (≥365 nmol/L) and salivary cortisone (≥37.2 nmol) predicted hypothalamic–pituitary–adrenal axis recovery with 100% specificity in 26.7% of pass short synacthen tests, whereas salivary cortisol predicted none. Baseline serum cortisol (≤170 nmol/L), salivary cortisone (≤9.42 nmol/L) and salivary cortisol (≤1.92 nmol/L) predicted hypothalamic–pituitary–adrenal suppression with 100% sensitivity in 58.5%, 53.7% and 51.2% of failed short synacthen tests, respectively. Using these cut-offs, baseline serum cortisol, salivary cortisone and salivary cortisol could reduce the need for short synacthen tests by 50%, 46% and 37%, respectively. Conclusion Although marginally inferior to early morning serum cortisol, early morning salivary cortisone may be used as a first-line test for assessing hypothalamic–pituitary–adrenal function. We plan to incorporate salivary cortisone into a home-based patient pathway to identify patients with hypothalamic–pituitary–adrenal recovery, continuing hypothalamic–pituitary–adrenal suppression and those who require a short synacthen test.
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Dissertations / Theses on the topic "Cortisol"

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Stegk, Jochen [Verfasser]. "11beta-Hydroxysteroid Dehydrogenasen in der Cortison/Cortisol-Umwandlung / Jochen Stegk." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1043957669/34.

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Krumbholz, Aniko. "Plasmaproteinbindung endogener Glucocorticosteroide und deren Einfluss auf Haar- und Speichelkonzentrationen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230609.

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Glucocorticosteroide (GC) spielen für viele endogene Prozesse im Organismus eine wichtige Rolle. Sie regulieren die Gluconeogenese sowie den Lipid- und Proteinstoffwechsel. Außerdem sind sie für die Stressregulierung über die Hypothalamus-Nebennierenrinden-Achse verantwortlich. Therapeutisch kommen die GCs wegen ihrer entzündungshemmenden Wirkung zum Einsatz und werden u.a. bei Asthma und Gelenkentzündungen angewandt. Diese Eigenschaft macht sie auch interessant für den Gebrauch im Sportbereich. Dort wird ihre Anwendung über die Weltantidopingagentur reguliert. Ihr oraler, intramuskulärer, intravenöser und rektaler Gebrauch ist im Wettkampf verboten. Diese Einschränkung bzgl. des Applikationszeitraumes und des Applikationsweges erschwert die diagnostische Aussagekraft von Routinedopingproben, welche im Urin durchgeführt werden. Ein Grenzwert von 30 ng/ml soll einen legalen Gebrauch von einem Missbrauch abgrenzen. Die endogenen Glucocorticosteroide stellen hierbei jedoch einen Graubereich dar. Endogen wird Cortisol in einem zirkadianen Rhythmus produziert und die Produktion ist stressinduziert. Somit kommt es zu ausgeprägten intra- und interindividuellen Streuungen der endogenen Produktion. Dadurch bedingt ist eine Abgrenzung der endogenen Produktion von einer legalen Anwendung bzw. einem Missbrauch im Rahmen der Dopingrichtlinien im Urin nicht möglich. Speziell für den Nachweis von endogenen Substanzen ist es wichtig, eine Methode zu finden, mit der es möglich ist, die endogene Produktion von einer exogenen Bezugsquelle abzugrenzen. Dabei haben sich zwei Wege als hilfreich herausgestellt. Zum einen, wenn die Differenzierung nicht an Hand von Absolutkonzentrationen sondern durch die Anwendung von Analytverhältnissen durchgeführt wird. Zum anderen, wenn zusätzliche Untersuchungen im Speichel oder Haar durchgeführt werden. Haar- und Speichelproben zählen zu den ergänzenden Matrizes der Routineuntersuchungsmedien Urin und Blut und werden bereits in vielen forensischen und klinischen Laboren für diagnostische Fragestellungen verwendet. Diese Matrizes liefern wichtige Hinweise auf den akuten (Speichel) oder chronischen/ zurückliegenden (Haar) Gebrauch bzw. Missbrauch von Medikamenten und Drogen. Sowohl die Haar- als auch Speichelmatrix sollen den physiologisch aktiven Anteil von Substanzen im Blut widerspiegeln und somit korrektere Rückschlüsse auf deren Wirksamkeit zulassen. Das endogene Glucocorticosteroid Cortisol steht seit der Jahrtausendwende im Blickpunkt vieler Forschungen, welche sich mit dessen Bedeutung für die Stressantwort befassen und Cortisol u.a. im Speichel und Haar nachweisen. Auffällig ist dabei, dass die ersten Arbeiten fast ausschließlich mittels immunchemischen Nachweisverfahren erfolgten. Erst in den letzten fünf Jahren wurde vermehrt LC-MS/MS-Verfahren angewandt. Vorteil dieser ist, dass der Nachweis von Substanzen selektiv erfolgt und Kreuzreaktionen nicht stattfinden. Weiterhin ist es vorteilhaft, dass die Konzentrationen von mehreren Analyten mit einer Messung bestimmt werden können. So ist es zum Beispiel möglich Cortisol und andere Steroide, z.B. dem Cortison parallel nachzuweisen. Cortison spielt für die physiologische Wirkung der Glucocorticosteroide im Körper keine Rolle, da es selbst nicht biologisch aktiv ist. Deshalb wurde es in bisherigen Forschungen für diagnostische Aussagen nicht berücksichtigt. Mit Verwendung der LC-MS/MS-Technologie werden jedoch beide endogenen GCs zunehmend nebeneinander bestimmt. Bei der Betrachtung von unterschiedlichen Untersuchungsmedien ist auffällig, dass sich die Konzentrationsverhältnisse Cortisol zu Cortison unterscheiden. Entgegengesetzte Verhält-nisse werden ersichtlich, wenn die GC-Konzentrationen im Blut mit denen im Speichel bzw. Haar verglichen werden. Bisher wurden diese Beobachtungen mit der lokalen Wirksamkeit von Enzymen, welche die Corticosteroide ineinander umwandeln, erklärt. Im Rahmen der vorliegenden Dissertation wurde folgender Fragestellung für die Nachweisbarkeit der Glucocorticosteroide nachgegangen: „Wie hoch ist der Anteil der Plasmaproteinbindung der GCs im Blut und welche Rückschlüsse lassen sich daraus auf die Konzentrationsverschiebung innerhalb der einzelnen Matrizes ziehen?“ Basierend auf die einzelnen Teilprojekte wurden sowohl Plasmaproben als auch Speichel- und Haarproben hinsichtlich ihrer GC-Konzentrationen analysiert. Die Untersuchung von Kontrollproben ermöglichte es, Referenzwerte unter Normalbedingungen zu erheben. Die Ergebnisse aus den Projekten ergaben, dass die beiden endogen GCs Cortisol und Cortison in unterschiedlichen Konzentrationsverhältnissen in den Analysenmedien vorkommen: Plasma: Gesamtkonzentration F:E ca. 3:1 freie Konzentrationen F:E ca. 1:1 Speichel: F:E ca. 1:5 Haar: F:E ca. 1:3 Die Bestimmung der Plasmaproteinbindung (PPB) beider endogener GCs hat gezeigt, dass Cortisol mit ca. 96 % stärker an die Transportproteine CBG und Albumin bindet als Cortison mit ca. 85 %. Dies führt dazu, dass sich die freien, nicht-proteingebundenen Konzentrationen angleichen und es zu einer Verhältnisverschiebung von Cortisol zu Cortison von 3:1 auf 1:1 kommt. Somit stehen vergleichbare Konzentrationen für die Inkorporation ins Haar bzw. die Diffusion in den Speichel zur Verfügung. Es konnte gezeigt werden, dass die freien Plasmakonzentrationen beider GC stark mit den Speichelkonzentrationen korrelieren. Cortisol aber unterproportional und Cortison überproportional vom Plasma in den Speichel übergeht. Dies kann mit zwei weiteren Mechanismen, welche während der Diffusion eine Rolle spielen, der unterschiedlichen Lipophilie und der Inaktivierung durch lokale Enzym-reaktionen, erklärt werden. Weiterhin wurde gezeigt, dass sich die Tagesrhythmik der GC-Produktion im Speichel abbilden lässt und eine starke Korrelation zwischen Cortison und Cortisol vorliegt. Mit Hilfe einer Grenzfunktion können endogene Referenzkonzentrationen definiert und Messdaten eingeordnet werden. Unter anderem wurde gezeigt, dass eine Hormonersatztherapie mit Hydrocortison zu einer Verschiebung der Metabolisierung und der PPB führt und somit ein Gebrauch/Missbrauch von GCs durch abweichende Konzentrationsverhältnisse nachweisbar ist. Speicheluntersuchungen während einer chronischen Stresssituation (Schwangerschaft) zeigen, dass die GC-Produktion stetig ansteigt und sich besonders die morgendlichen Werte unterscheiden. Um die tageszeitlichen und stressbedingten Schwankungen der GC-Produktion auszublenden und eine längere Zeitspanne zu betrachten, wurden zusätzlich Haarproben analysiert. In diesen wurde ein kontinuierlicher Anstieg der GCs in den proximalen Haarsegmenten nachgewiesen, was auf eine kontinuierlich erhöhte Inkorporation während der chronischen Stresssituation schließen lässt. Außerdem wurde gezeigt, dass die Haarkonzentrationen dem Auswascheffekt unterliegen und die nachweisbaren Konzentrationen geringer werden, je älter das Haar wird. Schlussfolgernd kann gesagt werden, dass beide Mechanismen (Einlagerung und Auswaschung) konkurrieren und deshalb Referenzdaten nur für das proximale Segment erhoben werden können. Für weitere Segmente sind die Auswirkungen der individuellen Einflüsse nicht mehr allgemeingültig kalkulierbar und nur noch intraindividuelle Vergleiche nach mehrmaliger Beprobung aussagekräftig. Sind die Effekte der verstärkten Inkorporation größer als die Auswaschung, lassen sich diese auch Monate später erkennen. Zusammenfassend kann gesagt werden, dass die Plasmaproteinbindung der GCs zur Verhältnisverschiebung der Konzentrationen im Blut, Speichel und Haar beiträgt. Etwa 50 % des beobachteten Effekts kann der PPB zugeordnet werden. Weitere Quellen sind die unterschiedliche Lipophilie der GCs und die enzymatische Umwandlung, welche im Rahmen der vorliegenden Arbeit jedoch nicht „quantitativ“ betrachtet wurden. Die enzymatische Inaktivierung wurde bis dato als Hauptverantwortliche für die Konzentrationsverschiebung diskutiert. Mit der aktuellen Arbeit wurde dies widerlegt, und die Plasmaproteinbindung als Hauptquelle identifiziert.
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Kilpatrick, K. W. E. "Measurement of urinary free cortisol and cortisone by high pressure liquid chromatography." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501303.

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Gordic, Milorad. "Theoretical modeling of cortisol sensor." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002689.

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Costa, Ludmila da Silva Tavares 1983. "Redução de estresse e de não colaboração em pacientes odontopediatricos : avaliação da eficacia de intervenção psicologica." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288795.

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Orientador: Rosana de Fatima Possobon
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O choro e o movimentar-se de modo nervoso podem ser considerados como respostas típicas de estresse, ou seja, conseqüências comportamentais da exposição a estímulos aversivos, tal como ocorre durante o tratamento odontológico. Isso sugere a necessidade da realização de intervenções psicológicas a fim de diminuir o nível de estresse da criança exposta à situação de tratamento. O objetivo deste estudo foi investigar a eficiência de estratégia psicológica de dessensiblização, com sessões planejadas para a adaptação da criança ao tratamento, visando à diminuição do nível de estresse verificado através do nível de cortisol salivar e o aumento do grau de colaboração do paciente durante o tratamento preventivo. A amostra foi composta por 10 crianças participantes dos programas oferecidos pelo Centro de Pesquisa e Atendimento para Pacientes Especiais (Cepae) da Faculdade de Odontologia de Piracicaba (FOP-Unicamp) (faixa etária de 40 a 52 meses) que manifestavam comportamentos de não colaboração durante os procedimentos odontológicos preventivos. As sessões experimentais foram planejadas com passos de aproximação sucessiva ao objetivo final, que era a realização de todos os procedimentos preventivos com colaboração da criança. O estresse experimentado pela criança, antes e depois das sessões experimentais, foi investigado por meio da avaliação dos níveis salivares de cortisol. Os resultados mostraram diferença significativa entre a média de comportamentos de não colaboração emitidos pelas crianças nas sessões inicial (44,6 ± 16,72) e final (5,40 ± 3,92) e diminuição da média da concentração de cortisol salivar entre a consulta inicial (0,65 ± 0,25 µg/dL) e final (0,24 ± 0,10 µg/dL). Após as sessões de dessensibilização, houve diminuição significativa dos comportamentos não colaboradores como choro, movimento nervoso, apreensão e esquiva, evidenciando a eficiência da estratégia. Conclui-se que a atuação de um profissional de Odontologia, preparado para lidar com questões comportamentais, pode contribuir para diminuir o grau de aversividade relacionada à situação de tratamento, melhorando o comportamento da criança durante a realização dos procedimentos clínicos e evitando a sua exposição à situações estressantes.
Abstract: Crying and moving around nervously can be considered as typical stress responses, therefore behavioral consequences of aversive stimuli exposure, such as what happens during dental treatment. This suggests the need for psychological treatments in order to reduce the levels of stress in the children exposed to these procedures. The objective of this study was to investigate the effectiveness of the desensitization psychological strategy, with planned sessions for the child's adaptation to the treatment, aiming to de decrease the stress levels (verified by the level of salivary cortisol) and the increase levels of collaboration of the patient during the preventive treatment. The sample was made up of 10 participating children form de Cepae-FOP-Unicamp (age range of 40 to 52 months) that presented non cooperation behavior during preventive dental procedures. The experimental sessions were planned with successive approximation steps to the final goal, which were the completion of all preventive procedures in collaboration with the child. The stress experienced by the child, before and after the experimental sessions, was investigated by evaluating the cortisol salivary levels. The results showed a significant difference between the average behavior of non cooperation issued by children in the initial sessions (44,6 ± 16,72) and final (5,40 ± 3,92) and a decrease in the average concentration of salivary cortisol in the initial session (0,65 ± 0,25 µg/dL) and the final (0,24 ± 0,10 µg/dL). Even more, after the desensitization sessions, there was a significant decrease of non cooperative behaviors as crying, nervous movements, apprehension and elusiveness. Concluding that the performance of the dentistry professional, prepared to deal with behavioral issues can contribute to lower the level of rejection related to the treatment, improving the behavior of the child during the clinical procedures and avoiding exposure to stressful situations.
Mestrado
Fisiologia Oral
Mestre em Odontologia
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Fernandes, Viviane Mendes. "Cortisol salivar e atenção auditiva sustentada." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/61/61132/tde-12062017-161255/.

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Objetivo:Verificar uma possívelcorrelação entre o nível de cortisol salivar e a atenção auditiva sustentada em crianças com fissura labiopalatina. Localde Execução:Hospital de Reabilitação de Anomalias Craniofaciais. Método:Estudo prospectivo com 69 crianças de seis a 11 anos de idade, com fissura labiopalatina, com audição normal e sem histórico de desatenção. As crianças foram submetidas à coleta de saliva, para a mensuração do nível de cortisol, e ao Teste de Habilidade de Atenção Auditiva Sustentada (THAAS), para verificar a atenção sustentada. Resultados:Os resultados demonstraram a ausência de significância estatística entre os sexos, tanto para o nível de cortisol quanto para a atenção auditiva sustentada. As crianças de 7 anos apresentaram os piores resultados na atenção sustentada e os mais altos níveis de cortisol salivar. Conclusão: Foi possível verificar correlação positiva, com diferença estatisticamente significativa, entre o nível de cortisol salivar e a habilidade de atenção auditiva sustentada apenas nas crianças com fissura labiopalatina na faixa etária de sete anos.
Objective: To verify a possible correlation between salivary cortisol level and sustained auditory attention in children with cleft lip and palate. Place of Execution: Hospital of Rehabilitationof Craniofacial Anomalies. Method:Prospective study with 69 children from 6 to 11 years of age, with cleft lip and palate, with normal hearing and no history of inattention. The children were submitted to saliva collection for the measurement of cortisollevel and to the Sustained Auditory Attention Ability Test(SAAAT) to verify sustained attention. Results:The results demonstrated the absence of statistical significance between the sexes, both for the cortisol level and for the sustained auditory attention. The 7-year-old children had the worst results in sustained attention and the highest levels of salivary cortisol. Conclusion:A positive correlation with a statistically significant difference between salivary cortisol level and sustained auditory attention ability was observed only in children with cleft lip and palate at the age of seven years.
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Bhagwagar, Zubin. "Serotonin, cortisol and vulnerability to depression." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410616.

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Ward, Janelle Wendy-Ann. "Feto-placental metabolism : regulation by cortisol." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619701.

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Hannen, Rosalind Francesca. "Cortisol synthesis by primary human keratinocytes." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/473.

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Cortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported. Keratinocytes are capable of de novo cholesterol synthesis, they express P450 enzymes that are required for steroidogenesis and can metabolise androgens and estrogens. In addition, steroidogenic acute regulatory protein (StAR) that controls the rate determining step of acute steroidogenesis has been identified in the epidermis. The aim of this thesis was to identify de novo cortisol steroidogenesis by keratinocytes and investigate the function of cortisol in keratinocytes in vitro. Normal epidermis was shown to express three cholesterol transporters that are associated with promoting steroid synthesis; StAR was identified in the basal layer, metastatic lymph node 64 (MLN64) in the suprabasal layers and translocator protein (TSPO) was detected throughout the epidermal layers. In addition, the nuclear receptor DAX1, a negative regulator of StAR, was identified in the cytoplasm of cells that form normal epidermis. Comparatively, the expression of these proteins was altered in psoriasis and atopic dermatitis, where DAX1 was localised to the nucleus of most diseased tissue and StAR was not detected. This suggests that acute steroid synthesis is ablated in these hyperproliferative skin conditions. The ability of normal primary human keratinocytes to synthesise cortisol was investigated. Radioimmunoassay demonstrated keratinocytes were capable of de novo pregnenolone synthesis, which was promoted with the cortisol analogue dexamethasone (dex). Interestingly, 25-hydroxycholesterol, which bypasses StAR, did not further enhance steroid synthesis. This suggests that there is an alternative rate determining step of steroid synthesis in cultured primary keratinocytes. Thin layer chromatography demonstrated keratinocytes could metabolise pregnenolone to progesterone and progesterone to cortisol. Progesterone metabolism to cortisol was also confirmed with liquid chromatography/mass spectroscopy. 3 Dex was shown to maintain keratinocyte viability and was implicated in promoting cellular redox potential. Since redox potential is a critical regulator of steroidogenesis, this observation could provide a mechanism for dex-induced pregnenolone synthesis in cultured keratinocytes. These observations led to a hypothesis that local cortisol synthesis functions to regulate cellular redox potential to prevent cell death as part of a positive feedback system. Therefore, this thesis has identified the cortisol steroidogenic pathway in primary human keratinocytes and a potential functional mechanism for the pathway.
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Santema, Peter. "Conflict, cooperation and cortisol in meerkats." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608222.

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Books on the topic "Cortisol"

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Lady Cortisol: Nouvela. Athēna: Ekdoseis Patakē, 2016.

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McK, Jefferies William, ed. Safe uses of cortisol. 2nd ed. Springfield, Ill., U.S.A: C.C. Thomas, 1996.

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A, Nunez Emmanuel, Sapse Alfred T. 1926-, Christeff Névéna, and Conference on Cortisol/Anti-Cortisols (1st : 1996 : Château de Fillerval, France), eds. Cortisol and anti-cortisol: Guest editors, Emmanuel A. Nunez, Alfred T. Sapse, Névéna Christeff. Oxford: Pergamon, 1997.

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Cholesterol: Interactions with testosterone and cortisol in cardiovascular diseases. Berlin: Springer-Verlag, 1987.

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Dover, Marcia. Urinary catecholamines and cortisol in attention deficity/hyperactivity disorder. [New Haven, Conn: s.n.], 1998.

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Kelsall, Christopher James. Urotensins and osmoregulation in the flounder: Effects on cortisol secretion. Manchester: University of Manchester, 1996.

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Vistakis, Vassilis. Analysis of salivary cortisol as an indicator of stress from venipuncture. Roehampton: University of Surrey Roehampton, 2002.

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Yu, Denise. Regulation of prostaglandin H2 synthase type-2 enzyme by cortisol and progesterone. Ottawa: National Library of Canada, 1999.

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Nash, Susan J. Psychobiological aspects of occupational stress: Tryptophan metabolites and cortisol in city executives. [Guildford]: [University of Surrey], 1996.

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Khairy, Noha M. The effects of sedative and stimulating music on state anxiety and salivary cortisol. London: University of Surrey Roehampton, 2000.

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Book chapters on the topic "Cortisol"

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Stalder, Tobias, and Clemens Kirschbaum. "Cortisol." In Encyclopedia of Behavioral Medicine, 561–67. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_171.

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Stalder, Tobias, and Clemens Kirschbaum. "Cortisol." In Encyclopedia of Behavioral Medicine, 507–12. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_171.

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Ramirez, Luis F. "Cortisol." In Encyclopedia of Immigrant Health, 496–97. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-5659-0_178.

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Soravia, Leila Maria, and Dominique J. F. de Quervain. "Cortisol." In Psychobiological Approaches for Anxiety Disorders, 109–22. Chichester, UK: John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119945901.ch7.

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Stalder, Tobias, and Clemens Kirschbaum. "Cortisol." In Encyclopedia of Behavioral Medicine, 1–7. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-6439-6_171-2.

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van Balen, J. A. M., A. A. Demeulemeester, M. Frölich, K. Mohrmann, L. M. Harms, W. C. H. van Helden, L. J. Mostert, and J. H. M. Souverijn. "Cortisol." In Memoboek, 64. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-9129-5_30.

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Hamilton, Lisa Dawn. "Cortisol." In Encyclopedia of Sexuality and Gender, 1–5. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-59531-3_7-1.

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Auer, Brandon J. "Increased Cortisol." In Encyclopedia of Evolutionary Psychological Science, 1–4. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-16999-6_760-1.

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Anderson, George M. "Cortisol, Serum." In Encyclopedia of Autism Spectrum Disorders, 817–18. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1406.

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Anderson, George M. "Cortisol, Serum." In Encyclopedia of Autism Spectrum Disorders, 1221–22. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_1406.

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Conference papers on the topic "Cortisol"

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Rodrigues, Sofia Danjos, Vitor De Paula Boechat Soares, Diúle Nunes Sales, Mariana Schmidt Cheaitou, and Crístia Rosineiri Gonçalves Lopes Corrêa. "CORTISOL E DEPRESSÃO." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/976.

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Introdução: Embora seja inegável o fator emocional, principalmente as vivências traumáticas infantis, a correlação entre a hipersecreção de cortisol e a depressão é uma das mais antigas da psiquiatria biológica. A literatura destaca que um indivíduo com alteração de comportamento aumentaria a produção de cortisol, o que teria efeito sobre a sua imunidade. Tal efeito, por sua vez, refletiria no SNA, sendo possível identificar uma leitura que aborda a depressão a partir da interação entre os sistemas psíquico, endócrino, imune e neurológico. Objetivo: Analisar a literatura dos últimos cinco anos acerca da correlação entre níveis elevados de cortisol e depressão. Método: Durante o mês de março de 2021, foram analisados artigos, em inglês, tendo como referência a base de dados MedLine via PubMed. Foi utilizado MeSH para obter as variações dos descritores e filtradas publicações dos últimos cinco anos. Resultados: De acordo com os resultados, embora, alguns estudos reivindiquem não existir relação ou apenas uma associação moderada entre depressão e cortisol, na maior parte dos artigos analisados tal associação ainda é defendida. Nesta direção, foi encontrada associação entre a baixa conectividade hipotálamo-hipocampo e a resposta elevada do cortisol em mulheres com alto humor disfórico. Ademais, foram identificados dano celular e disfunção mitocondrial causados por estresse crônico, podendo levar à liberação de DNA mitocondrial (mtDNA) na corrente sanguínea. O Transtorno de Depressão Maior (TDM) foi associado a uma quantidade aumentada de mtDNA em leucócitos; e as tentativas de suicídio e a hiperatividade do eixo hipotálamo hipófise adrenal a uma elevação dos níveis plasmáticos mtDNA. Pode-se observar ainda que em pacientes depressivos com psicose, os níveis de cortisol mostraram-se aumentados quando comparados a pacientes com TDM sem psicose. Além disso, foi verificado que hipercortisolemia com envolvimento de diminuída concentração de TNF-alfa pode desempenhar um importante papel na supressão da resposta IgG em pacientes deprimidos. Por fim, em pacientes com TDM, a influência dos traumas ocorridos na infância sobre a severidade da depressão foi mediada tanto por atitudes disfuncionais como por níveis de cortisol. Conclusão: O cortisol ainda pode ser considerado um biomarcador confiável, não invasivo e de baixo custo para pacientes psiquiátricos.
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Semwal, Vivek, Jonas Højgaard, Emil Møller, and Jakob Janting. "Fluorescence based Polymer Optical Fiber Cortisol Sensor for Aquaculture." In Optical Fiber Sensors. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/ofs.2022.w4.51.

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Our aim is an efficient online cortisol sensor for aquaculture. We present a polymer optical fiber sensor design for cortisol using a competitive assay consisting of fluorophore tagged cortisol and a cortisol aptamer.
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Frederiksen, Thomas Winther, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Matias Brødsgaard Grynderup, Åse Marie Hansen, Søren Peter Lund, Jesper Kristiansen, Jesper Medom Vestergaard, Jens Peter Bonde, and Henrik Kolstad. "P121 Salivary cortisol and tinnitus." In Occupational Health: Think Globally, Act Locally, EPICOH 2016, September 4–7, 2016, Barcelona, Spain. BMJ Publishing Group Ltd, 2016. http://dx.doi.org/10.1136/oemed-2016-103951.438.

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KENNEY MC FADDEN, SAMANTHA, ÉRICA A. M. CAMARGO, FERNANDO CANOVA, PRISCILA C. SILVA, FILIPY BORGHI, PEDRO FIDELIS, AGLÉCIO L. DE SOUZA, MARIA SILVIA M. PIRES DE CAMPOS, and Dora Maria Grassi Kassisse. "Salivar cortisol from undergraduated students." In XXIV Congresso de Iniciação Científica da UNICAMP - 2016. Campinas - SP, Brazil: Galoa, 2016. http://dx.doi.org/10.19146/pibic-2016-50974.

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Barbosa, Breno, Juliana de Souza Talarico, Ricardo Nitrini, Sônia Brucki, and Maira de Oliveira. "CORTISOL LEVELS AND COGNITIVE STATUS IN ELDERLY SUBJECTS: PRELIMINARY RESULTS FROM A MEMORY COHORT." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda065.

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Background: There’s a growing body of research evaluating chronic stress as potentially preventable risk factor for dementia. Objective: To investigate whether chronic stress or cortisol measures are associated with cognitive status and dementia biomarkers. Methods: Transversal analysis to evaluate the relation between cortisol levels, amyloid pathology and cognitive status in a subset subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and controls. Chronic stress evaluation involved anthropometric measures, serum cortisol and DHEA-sulfate, glycated hemoglobin, total and HDL cholesterol, creatinine, fibrinogen and reactive protein-C. Exclusion criteria included dementia and corticosteroids use. Results: 50 participants with serum cortisol levels available were included for analysis. Mean age was 71.8 years (SD + 5.2), with 36 female patients (50%), 11.3 years of education (SD + 5). Amnestic MCI was the most prevalent cognitive status (40%), followed by non-amnestic MCI (28%) and SCD (21%). 24 subjects had access to amyloid status assessment with PET-PiB (9 positive, 15 negative). In our sample the mean serum cortisol level was 9.09 mg/dL (+SD 4.1), with 12 individuals in the first tercile (24%), 30 in the middle tercile (60%) and 8 in the upper tercile (16%). Individuals in the lower cortisol tercile had more positive PET-PiB scans, while in the middle cortisol tercile all individuals had negative scans (p = 0.007 | Fisher’s test). Conclusion: Despite the modest sample size, there was a significant inverse association between cortisol terciles and amyloid status. More longitudinal cortisol measures (ie. salivary, urinary or hair) and a larger sample size could give us more information.
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Biriukova, Olga, Yu Lesniak, D. Basovskiy, and N. Vintoniv. "Dynamics of the cortisol level in the blood of young cattle." In Scientific and practical conference with international participation: "Management of the genetic fund of animals – problems, solutions, outlooks". Scientific Practical Institute of Biotechnologies in Animal Husbandry and Veterinary Medicine, 2023. http://dx.doi.org/10.61562/mgfa2023.03.

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The aim of the study was to evaluate the biological patterns of the dynamics of cortisol levels in the blood serum of calves of the Ukrainian Red-and-White dairy breed. According to the results of the eosinophilic test, 52.4% of individual’s resistant to stress were identified in the group of studied calves. Of all the calves assessed as resistant to the stressor, 68.2% were bulls. The average level of cortisol in calves was 26.2±0.8 ng/ml. As the age of the calves’ increases, there is an increase in the concentration of cortisol in the blood serum. The intensity of the increase in the level of cortisol in different periods of postnatal ontogenesis is uneven. A high direct statistically significant rank correlation was recorded between the levels of cortisol in the blood serum of calves at different ages (r=+0.89±0.054 - + 0.99±0.117, P<0.001). It has been established that the change in the level of cortisol in the blood serum of calves in the process of postnatal ontogenesis depends on gender. In bulls, serum cortisol concentration was significantly lower (on average by 66%, P<0.01).
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Murni, Arina, Ellyza Nasrul, and Fadrian Fadrian. "Analysis of Plasma Cortisol Level and Salivary Cortisol Level in Chronic Kidney Disease Patients with Depression." In Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia. EAI, 2019. http://dx.doi.org/10.4108/eai.13-11-2018.2283798.

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Gomez, Manuel, Samuel Montalvo, Daniel Conde, and Gabriel Ibarra-Mejia. "Differences in Circulating Cortisol Levels After Completing Hand Ergometer Exercise with and Without Graded Compression Arm Sleeves." In 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003954.

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Cortisol has many physiological effects on the human body and its concentration increases in an intensity-dependent manner. The prolonged physical stress increases total cortisol concentration. Anecdotal data suggests that using graded compression sleeves forearm alleviates pain in the upper and lower limbs. The physiological mechanisms underlying these benefits are not fully understood. This study aimed to assess the effects of wearing graded compression (13-18 mmHg) sleeves on circulating cortisol after completing a physical activity with three different intensities. The study included six participants between 18 and 25 years old without a known history of injuries in the upper limbs. The proper sleeve size was fitted to the participants following the manufacturer’s instructions (On-Site Therapy, Tallahassee,FL.), and anthropometric measurements were taken. All the participants randomly completed a cycle hand ergometer exercise at 60 RPM at 25 W., 50 W., and 75 W for a maximum of 10 minutes with and without forearm sleeves. All the participants rested for at least 72 hours before the next exercise session to avoid muscular fatigue. Venous blood samples were drawn before and after completing each session to compare the effects of wearing graded compression sleeves on the circulating cortisol concentration. Cortisol concentrations were analyzed by enzyme link immunosorbent assay (ELISA). A Linear mixed-effects model was used for analysis. Participants wearing the compression sleeves showed a significant decrease in cortisol concentration at 50 W only. This study shows the potential benefits of wearing compression sleeves while performing activities involving the upper limbs. Even though our results show a decrease in cortisol concentration at 50 W., a larger sample size would be needed to dictate a significant difference in the physiological response associated with the use of graded compression sleeves.
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Aflahiyah, Shiva, Didik Gunawan Tamtomo, and Hanung Prasetya. "A Meta-Analysis on the Effectiveness of Prenatal Yoga in Reducing Cortisol Hormone in Pregnancy." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.47.

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ABSTRACT Backgrund: A growing body of evidence suggests that activity of the stress-responsive hypothalamic-pituitary-adrenal axis and its end-product cortisol also may be associated with perinatal emotional well-being. A number of preventive interventions, such as Yoga, targeting psychosocial and physiological risk factors for perinatal depression have utilized mind-body practices, which embody the idea that the mind interacts with the body to influence physical functioning, improve symptoms, and promote health. This study aimed to investigate effectiveness of prenatal yoga in reducing cortisol hormone in pregnancy Subjects and Method: This was a meta-analysis and systematic review. This study collected published articles during 2000 to 2020 from PubMed, Science Direct, Springer, Proquest, and Chocrane electronic databases. The inclusion criteria were full text, randomized controlled trial, and prenatal yoga intervention. The study subjects were pregnant women who received prenatal yoga for 8 to 20 weeks. Outcome was cortisol hormone reduction during pregnancy. The selected articles were analyzed by PRISMA flow chart and RevMan 5.3. Results: 5 articles from America and Asia were met the inclusion criteria. This study had high heterogeneity (I2=88%; p<0.001). Therefore, this study used random effect model (REM). Prenatal yoga reduced cortisol level 0.59 times in pregnancy (Mean Difference= -0.59; 95% CI= 1.18 to 0.01; p= 0.050). Conclusion: Prenatal yoga is effective to reduce cortisol level in pregnant women. Keywords: prenatal yoga, cortisol hormone, pregnant women Correspondence: Shiva Aflahiyah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: shivaafla@gmail.com. DOI: https://doi.org/10.26911/the7thicph.05.47
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Milekhin, I. A., O. P. Cherkasova, A. G. Milekhin, S. A. Kuznetsov, E. E. Rodyakina, V. A. Minaeva, and A. V. Latyshev. "Surface-enhanced infrared spectroscopy for cortisol analysis." In 2018 International Conference Laser Optics (ICLO). IEEE, 2018. http://dx.doi.org/10.1109/lo.2018.8435798.

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Reports on the topic "Cortisol"

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Bechshoeft, Thea. Measuring Baseline Cortisol Levels in Cetaceans: Developing a Novel Non-Invasive Analysis Method. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada573313.

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Hensch, Melissa, Lori L. Layman, Locke A. Karriker, Johann F. Coetzee, Analia Roca, and Anna K. Johnson. Using Serum Cortisol to Distinguish Between Acute Stress and Pain Response Following Castration in Piglets. Ames (Iowa): Iowa State University, January 2011. http://dx.doi.org/10.31274/ans_air-180814-648.

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Hidayat, Rachmat, Patricia Wulandari, and Lusia Hayati. Does Cognitive Behavioural Therapy Affect Perceived Stress, Anxiety-depression Scores and Saliva Cortisol in Depression? "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2021. http://dx.doi.org/10.7546/crabs.2021.03.17.

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Colonetti, Tamy, Vanessa Fritzen, Renan Ceretta, Maria Ines Rosa, and Mateus Cruz. Levels of salivary cortisol in adults and children with Bruxism diagnostics: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2020. http://dx.doi.org/10.37766/inplasy2020.3.0003.

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Lee, Jack M. Seasonal Patterns of Melatonin, Cortisol, and Progesterone Secretion in Female Lambs Raised Beneath a 500-kV Transmission Line. Office of Scientific and Technical Information (OSTI), June 1992. http://dx.doi.org/10.2172/6973353.

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Mohling, Caroline M., Monique D. Pairis-Garcia, Anna K. Johnson, Kenneth J. Stalder, Locke A. Karriker, Johann F. Coetzee, and Suzanne T. Millman. Blood Cortisol as an Objective Tool to Measure Painful and Non-painful Hoof Lameness States in Multiparous Sows. Ames (Iowa): Iowa State University, January 2013. http://dx.doi.org/10.31274/ans_air-180814-863.

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Lee, Jack. Seasonal Patterns of Melatonin, Cortisol, and Progesterone Secretion in Female Lambs Raised Beneath a 500-kV Transmission Line. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1316.

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Bechshoft, Thea. Validating the Novel Method of Measuring Cortisol Levels in Cetacean Skin by use of an ACTH Challenge in Bottlenose Dolphins. Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ad1013955.

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Biehl, María Loreto, Raquel Fernández-Coto, and Hazel Elizondo Barboza. Menos violencia, más aprendizaje: Un análisis neurocientífico de jóvenes en Honduras. Inter-American Development Bank, February 2021. http://dx.doi.org/10.18235/0003229.

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La violencia en Latinoamérica forma parte de la cotidianeidad de muchos jóvenes en edad de asistir a la secundaria. Además del efecto que esto acarrea en su rendimiento y asistencia escolar, resulta de interés conocer los efectos a nivel cerebral y las implicaciones que esto puede generar en sus funciones cognitivas. Honduras se perfila como uno de los países con los mayores índices de violencia y criminalidad no solamente a nivel Latinoamericano sino también a nivel mundial. Enmarcado en el contexto anterior, el presente documento presenta los principales hallazgos del estudio neurocientífico El Cerebro Adolescente Expuesto a la Violencia Escolar (2019), realizado por la Universidad Nacional Autónoma de Honduras, específicamente por el Grupo de Investigación de Neurociencias Aplicadas de la Universidad, en colaboración con el Banco Interamericano de Desarrollo. Dicho estudio incluyó 117 estudiantes de edades entre 14 y 17 años de tres centros educativos de secundaria. Los resultados arrojan que efectivamente aquellos estudiantes con exposición más alta a la violencia producen en promedio más cortisol, conocida como la hormona del estrés, que aquellos expuestos a un nivel de violencia bajo. Aunado a lo anterior, se generó evidencia de que la alta exposición a la violencia genera hiperconectividad en las redes neuronales del cerebro, lo que repercute en el desempeño de funciones cognitivas relevantes como son la memoria, la percepción y la atención. Por último, en el área de aprendizaje, los estudiantes con mayor exposición a la violencia obtuvieron resultados más bajos en pruebas estandarizadas de español y matemática, al compararse con aquellos estudiantes con niveles más bajos de exposición a la violencia.
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Noga, Edward J., Ramy R. Avtalion, and Michael Levy. Comparison of the Immune Response of Striped Bass and Hybrid Bass. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568749.bard.

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We developed methods for examining the pathophysical response of striped bass and hybrid bass to various forms of stress. This involved development of techniques for the measurement of lysozyme, mitogen blastogenesis, mixed lymphocyte reaction, and oxidative burst, which are important general indicators of systemic immune function. We also examined local immune defenses (epithelial integrity), as well as homeostatic indicators in blood, including osmotic balance and glucose. Acute stress resulted in significant perturbations in a number of parameters, including glucose, electrolytes, osmolarity, lysozyme, and mixed lymphocyte reaction. Most significantly, acute confinement stress resulted in severe damage to the epidermal epithelium, as indicated by the rapid (within 2 hr) development of erosions and ulcerations on various fins. There were significant differences in the resting levels of some immune functions between striped bass and hybrid bass, including response to mitogens in the leukocyte blastogenesis test. Our studies also revealed that there were significant differences in how striped bass and hybrid bass respond to stress, with striped bass being much more severely affected by stress than the hybrid. This was reflected in more severe changes in glucose, cortisol dynamics, and plasma lysozyme. Most significantly, striped bass developed more severe idiopathic skin ulceration after stress, which may be a major reason why this fish is so prone to develop opportunistic bacterial and fungal infections after stress. Hybrid bass injected with equine serum albumin developed a typical humoral immune response, with peak antibody production 28 days after primary immunization. Fish that were exposed to a chronic stress after a primary immunization showed almost complete inhibition of antibody production.
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