Relevant bibliographies by topics / Corticosterone

Academic literature on the topic 'Corticosterone'

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Published: 4 June 2021
Last updated: 1 June 2024

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Journal articles on the topic "Corticosterone"

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Cohen, Alia, Lia Savu, Roger Vranckx, Michelle Maya, and Emmanuel A. Nunez. "Effect of adrenalectomy at different pregnancy stages on maternal and fetal serum corticosteroid binding globulin and corticosterone in the rat." Acta Endocrinologica 122, no. 1 (January 1990): 121–26. http://dx.doi.org/10.1530/acta.0.1220121.

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Abstract The response of pregnant rat corticosteroid binding globulin to maternal adrenalectomy was studied as a function of the stage of pregnancy. Non-pregnant or pregnant rats were deprived of their adrenal glands during 4 days. In non-pregnant animals, adrenalectomy led to undetectable corticosterone levels and to the doubling of corticosteroid binding globulin. In pregnant rats adrenalectomized at 12 days and studied at 16 days, the serum corticosterone was likewise undetectable and the corticosteroid binding globulin was doubled as compared with pregnant rats of the corresponding age. In contrast, adrenalectomy from day 14 to 18 or from day 16 to 20 did not deplete the maternal serum corticosterone and the corticosteroid binding globulin remained unchanged. Under these conditions neither fetal corticosteroid binding globulin nor fetal corticosterone were modified. However, when the pregnant rats adrenalectomized from day 16 to 20 also received an injection of 30 mg of metyrapone on days 19 and 20 in order to inhibit fetal adrenal secretion, the maternal response was again a depletion of serum corticosterone together with an increase in corticosteroid binding globulin. Under these conditions, the fetus also reacted by a fall of corticosterone and a rise of corticosteroid binding globulin. Our results suggest that the maternal response of corticosteroid binding globulin to adrenalectomy depends on the pregnancy stage inasmuch as it may be influenced by a supply of corticosterone from the fetus during late pregnancy. Moreover, they show that in this late period, fetal corticosteroid binding globulin is regulated independently.
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Washburn, Brian E., Dana L. Morris, Joshua J. Millspaugh, John Faaborg, and John H. Schulz. "Using a Commercially Available Radioimmunoassay to Quantify Corticosterone in Avian Plasma." Condor 104, no. 3 (August 1, 2002): 558–63. http://dx.doi.org/10.1093/condor/104.3.558.

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AbstractUsing a commercially available corticosterone I125 double-antibody radioimmunoassay, we developed and validated an assay procedure for determining corticosterone levels in small-volume (≤30 μL) avian plasma samples. We evaluated this procedure's utility by measuring plasma corticosterone levels in Indigo Buntings (Passerina cyanea), American Goldfinches (Carduelis tristis), Red-eyed Vireos (Vireo olivaceus), and Mourning Doves (Zenaida macroura). Standard biochemical validations (e.g., parallelism, recovery of exogenous corticosterone) demonstrated that the assay accurately and precisely measured corticosterone in avian plasma. We used a stress capture protocol to physiologically validate the assay's ability to determine biologically important changes in corticosterone levels. Males and females from four bird species exhibited a significant increase in plasma corticosterone in response to capture, handling, and restraint. Baseline and stress-induced corticosterone levels in our study were similar to reported values for other passerine species using other radioimmunoassay procedures. Our results suggest that this radioimmunoassay procedure is very effective for determining corticosterone levels in small-volume avian plasma samples and is sensitive enough to detect biologically important changes in the adrenocortical activity of birds. Thus, this assay has considerable utility for measuring stress levels and stress responses in small birds (<15 g), from which only small volumes of plasma (≤30 μL) can be collected.Utilización de un Radioinmunoensayo Disponible Comercialmente para la Cuantificación de Corticosterona en el Plasma de AvesResumen. Desarrollamos y validamos un proceso de ensayo para determinar los niveles de corticosterona en muestras de pequeño volúmen (≤30 μL) de plasma de aves utilizando un radioinmunoensayo para corticosterona I125 de doble anticuerpo disponible comercialmente. Evaluamos este procedimiento midiendo los niveles de corticosterona en Passerina cyanea, Carduelis tristis, Vireo olivaceus y Zenaida macroura. Validaciones bioquímicas estándares (e.g., paralelismo, recuperación de corticoesteroide exógeno) demostraron que el ensayo midió de modo exacto y preciso la corticosterona en el plasma de las aves. Utilizamos un protocolo de captura que producía estrés para validar fisiológicamente la habilidad del ensayo de detectar cambios biológicamente importantes en los niveles de corticosterona. Hembras y machos de las cuatro especies de aves mostraron un incremento significativo en los niveles de corticosterona en el plasma en respuesta a la captura, manipulación y retención. Los niveles basales e inducidos por el estrés de nuestro estudio fueron similares a valores reportados para otras especies paserinas que utilizaron otros procedimientos de inmunoensayo. Nuestros resultados sugieren que este procedimiento de radioinmunoensayo es muy efectivo para determinar los niveles de corticosterona en muestras de pequeño volúmen de plasma de aves y que es suficientemente sensible como para detectar cambios biológicamente importantes en la actividad adenocortical de las aves. De esta manera, este ensayo presenta considerable utilidad para medir los niveles y respuesta al estrés en aves pequeñas (<15 g) de las cuales sólo es posible colectar pequeños volúmenes de plasma (≤30 μL).
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Goymann, Wolfgang, Erich Möstl, and Eberhard Gwinner. "Corticosterone Metabolites can be Measured Noninvasively in Excreta of European Stonechats (Saxicola torquata rubicola)." Auk 119, no. 4 (October 1, 2002): 1167–73. http://dx.doi.org/10.1093/auk/119.4.1167.

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Abstract Measurements of corticosterone levels from blood samples of birds provide accurate snapshots of systemic hormone concentrations. However, those birds must be caught and handled, which may be unfeasible especially when multiple sampling is required. Furthermore, handling causes stress and may therefore interfere with hormone measurements. Therefore a non-invasive technique was developed to measure metabolites of corticosterone in excreta of European Stonechats (Saxicola torquata rubicola) using a corticosterone enzyme-immunoassay. High-performance liquid chromatography of excreta of a female and a male stonechat injected with tritiated corticosterone showed that corticosterone is excreted in the form of numerous metabolites and that the corticosterone enzyme-immunoassay cross-reacted with most of those metabolites. Injection of adrenocorticotrophic hormone in one female and seven male stonechats led to a significant increase in the levels of excreted corticosteroid metabolites within 1 h 20 min after administration of adrenocorticotrophic hormone. These results suggest that the corticosterone enzyme-immunoassay used in this study provides a quantitative measure of excreted corticosteroid metabolite levels in European Stonechats and has the potential to replace plasma measurements of these hormones.
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Droste, Susanne K., Lotte de Groote, Helen C. Atkinson, Stafford L. Lightman, Johannes M. H. M. Reul, and Astrid C. E. Linthorst. "Corticosterone Levels in the Brain Show a Distinct Ultradian Rhythm but a Delayed Response to Forced Swim Stress." Endocrinology 149, no. 7 (March 20, 2008): 3244–53. http://dx.doi.org/10.1210/en.2008-0103.

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Circulating corticosterone levels show an ultradian rhythm resulting from the pulsatile release of glucocorticoid hormone by the adrenal cortex. Because the pattern of hormone availability to corticosteroid receptors is of functional significance, it is important to determine whether there is also a pulsatile pattern of corticosterone concentration within target tissues such as the brain. Furthermore, it is unclear whether measurements of plasma corticosterone levels accurately reflect corticosterone levels in the brain. Given that the hippocampus is a principal site of glucocorticoid action, we investigated in male rats hippocampal extracellular corticosterone concentrations under baseline and stress conditions using rapid-sampling in vivo microdialysis. We found that hippocampal extracellular corticosterone concentrations show a distinct circadian and ultradian rhythm. The PULSAR algorithm revealed that the pulse frequency of hippocampal corticosterone is 1.03 ± 0.07 pulses/h between 0900 and 1500 h and is significantly higher between 1500 and 2100 h (1.31 ± 0.05). The hippocampal corticosterone response to stress is stressor dependent but resumes a normal ultradian pattern rapidly after the termination of the stress response. Similar observations were made in the caudate putamen. Importantly, simultaneous measurements of plasma and hippocampal glucocorticoid levels showed that under stress conditions corticosterone in the brain peaks 20 min later than in plasma but clears concurrently, resulting in a smaller exposure of the brain to stress-induced hormone than would be predicted by plasma hormone concentrations. These data are the first to demonstrate that the ultradian rhythm of corticosterone is maintained over the blood-brain barrier and that tissue responses cannot be reliably predicted from the measurement of plasma corticosterone levels.
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Müller, Claudia, Bettina Almasi, Alexandre Roulin, Creagh W. Breuner, Susanne Jenni-Eiermann, and Lukas Jenni. "Effects of corticosterone pellets on baseline and stress-induced corticosterone and corticosteroid-binding-globulin." General and Comparative Endocrinology 160, no. 1 (January 2009): 59–66. http://dx.doi.org/10.1016/j.ygcen.2008.10.018.

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Hanafusa, Junko, Tomoatsu Mune, Tetsuya Tanahashi, Yukinori Isomura, Tetsuya Suwa, Mako Isaji, Hisashi Daido, Hiroyuki Morita, Masanori Murayama, and Keigo Yasuda. "Altered corticosteroid metabolism differentially affects pituitary corticotropin response." American Journal of Physiology-Endocrinology and Metabolism 282, no. 2 (February 1, 2002): E466—E473. http://dx.doi.org/10.1152/ajpendo.00065.2001.

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To evaluate the effects of altered corticosteroid metabolism on the hypothalamic-pituitary-adrenal axis, we examined rats treated with glycyrrhizic acid (G rats) or rifampicin (R rats) for 7 days. The half-life of exogenously administered hydrocortisone as a substitute for corticosterone was longer in G rats and shorter in R rats, with no differences in basal plasma levels of ACTH or corticosterone. The ACTH responses to human corticotropin-releasing factor (CRF) or insulin-induced hypoglycemia were greater in G rats and tended to be smaller in R rats compared with those in the control rats, whereas the corticosterone response was similar. No difference was observed in the content and mRNA level of hypothalamic CRF among the groups. The number and mRNA level of CRF receptor and type 1 11β-hydroxysteroid dehydrogenase (11-HSD1) mRNA level in the pituitary were increased in G rats but not changed in R rats, suggesting that chronically increased intrapituitary corticosterone upregulates pituitary CRF receptor expression. In contrast, CRF mRNA levels in the pituitary were increased in R rats. Our data indicate novel mechanisms of corticosteroid metabolic modulation and the involvement of pituitary 11-HSD1 and CRF in glucocorticoid feedback physiology.
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Romero, L. Michael, and Robin C. Romero. "Corticosterone Responses in Wild Birds: The Importance of Rapid Initial Sampling." Condor 104, no. 1 (February 1, 2002): 129–35. http://dx.doi.org/10.1093/condor/104.1.129.

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Abstract Corticosterone concentrations in birds usually rise in response to capture and handling, and it is often assumed that this change is predictable. We tested this assumption by leaving Gambel's White-crowned Sparrows (Zonotrichia leucophrys gambelii), House Sparrows (Passer domesticus), and Lapland Longspurs (Calcarius lapponicus) in nets or traps for 15 min following capture and comparing their corticosterone response over the next 60 min with birds removed immediately. White-crowned Sparrows and House Sparrows left in mist nets for 15 min and then bled had significantly elevated corticosterone concentrations compared to controls that were immediately removed from the net and bled. Corticosterone concentrations over the next 45 min of handling and restraint were similar between groups. In another experiment, White-crowned Sparrows and Lapland Longspurs were captured using seed-baited Potter traps. The corticosterone response of White-crowned Sparrows left in the trap for 15 min did not differ from White-crowned Sparrows removed immediately. Leaving Lapland Longspurs in the trap had no effect in the initial 10 min of handling and restraint, but at 30 and 60 min these birds had significantly lower corticosterone concentrations than longspurs removed immediately from the trap. These data indicate that failing to immediately remove birds from nets or traps can alter the corticosterone response to subsequent stressful stimuli in unpredictable ways. This result emphasizes that the elapsed time from capture is a critical variable in assessing stress responses in free-living birds. Respuestas de los Niveles de Corticosterona en Aves Silvestres: La Importancia de un Muestreo Inicial Inmediato Resumen. Las concentraciones de corticosterona en las aves usualmente aumentan en respuesta a la captura y manipulación, y muchas veces se supone que estos cambios son predecibles. Pusimos a prueba esta suposición reteniendo individuos de las especies Zonotrichia leucophrys gambelii, Passer domesticus y Calcarius lapponicus en redes o trampas durante los 15 minutos subsecuentes a la captura y comparamos sus respuestas en los niveles de corticosterona durante los siguientes 60 minutos con las de individuos removidos inmediatamente de las trampas y redes. Las muestras de sangre de Z. l. gambelii y P. domesticus que fueron obtenidas después de 15 minutos de retención en las redes tuvieron niveles de corticosterona significativamente más altos que las de los individuos control obtenidas inmediatamente después de la captura. Durante los 45 minutos siguientes de manipulación y captura, las concentraciones de corticosterona fueron similares entre los dos grupos. En otro experimento, Z. l. gambelii y C. lapponicus fueron capturados mediante trampas “Potter” cebadas con semillas. La respuesta en los niveles de corticosterona de Z. l. gambelii no fue diferente entre individuos retenidos en las trampas por 15 minutos e individuos removidos inmediatamente. Para individuos de C. lapponicus retenidos en las trampas no hubo un efecto durante los 10 minutos iniciales de manipulación y captura, pero a los 30 y 60 minutos estas aves tuvieron concentraciones significativamente menores que los individuos removidos inmediatamente. Estos resultados indican que al no remover inmediatamente a las aves de las redes o trampas, las respuestas en los niveles de corticosterona a estímulos estresantes pueden verse alteradas de una manera impredecible. Estos resultados enfatizan que en aves silvestres, el lapso de tiempo desde la captura es una variable crítica en la determinación de las respuestas al estrés.
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Remage-Healey, Luke, and L. Michael Romero. "Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281, no. 3 (September 1, 2001): R994—R1003. http://dx.doi.org/10.1152/ajpregu.2001.281.3.r994.

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Captive European starlings ( Sturnus vulgaris) were exposed to the stress of handling and restraint while corticosterone, glucose, and triglyceride concentrations were monitored in blood plasma. In saline-injected controls, basal samples were taken within 3 min of disturbance with subsequent samples taken at 40, 70, and 150 min. This was repeated at two times during the daily cycle (day and night) on two different photoperiods: short and long days. During both photoperiods, corticosterone concentrations approximately tripled (compared with a sixfold increase in free-living starlings) and triglyceride concentrations decreased 25–45% in response to stress at both times of the day, whereas an ∼25% stress-induced hyperglycemia occurred only at night. Exogenous corticosterone (200 μg), 1.0 or 4.0 IU/kg of insulin, or a combination of corticosterone with each insulin dose was then separately administered to alter the above responses. Insulin did not affect corticosterone or triglyceride concentrations but resulted in a dose-dependent hypoglycemia of 10–40%. Injected corticosterone resulted in supraphysiological corticosterone concentrations (three- to fivefold higher than normal), yet it did not affect the already altered plasma glucose or triglyceride concentrations. This suggests that glucose output and triglyceride decreases were already maximal in response to handling and restraint. However, the low glucose concentrations resulting from exogenous insulin returned to basal quicker with exogenous corticosterone but only during the day. No response to either hormone showed photoperiodic differences. These data suggest that corticosterone's role in metabolism changes to meet varying energetic demands throughout the day.
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Sheppard, K., and J. W. Funder. "Mineralocorticoid specificity of renal type I receptors: in vivo binding studies." American Journal of Physiology-Endocrinology and Metabolism 252, no. 2 (February 1, 1987): E224—E229. http://dx.doi.org/10.1152/ajpendo.1987.252.2.e224.

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We have injected rats with [3H]aldosterone or [3H]corticosterone, plus 100-fold excess of the highly specific glucocorticoid RU 28362, with or without excess unlabeled aldosterone or corticosterone and compared type I receptor occupancy in kidney and hippocampus. Thirty minutes after subcutaneous injection [3H]aldosterone was well retained in renal papilla-inner medulla, renal cortex-outer medulla, and hippocampus; in contrast, [3H]corticosterone was well retained only in hippocampus. Competition studies for [3H]aldosterone binding sites showed corticosterone to be a poor competitor in the kidney compared with hippocampus. Time-course studies, with rats killed 10-180 min after tracer administration, showed very low uptake/retention of [3H]corticosterone by kidney; in hippocampus [3H]corticosterone retention was similar to that of [3H]aldosterone in kidney, and retention of [3H]aldosterone by hippocampus was much more prolonged than of either tracer in any other tissue. Studies in 10-day-old rats, with very low levels of corticosteroid binding globulin (CBG), showed a high degree of aldosterone selectivity in both zones of the kidney, whereas [3H]aldosterone and [3H]corticosterone were equivalently bound in hippocampus. We interpret these data as evidence for a mechanism unrelated to extravascular CBG conferring mineralocorticoid specificity on renal type I receptors and propose two models derived from our findings consistent with such differential selectivity.
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Filaretova, L. P., A. A. Filaretov, and G. B. Makara. "Corticosterone increase inhibits stress-induced gastric erosions in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 6 (June 1, 1998): G1024—G1030. http://dx.doi.org/10.1152/ajpgi.1998.274.6.g1024.

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The role of glucocorticoids released in response to stress in the pathogenesis of stress-induced gastric erosions has been reevaluated. Gastric erosions elicited in male rats by 3-h cold-restraint or water-restraint stresses were studied after acute reduction of corticosterone release or occupation of glucocorticoid receptors by the antagonist RU-38486 during stress. Stress-induced corticosterone production was reduced by creating a lesion on the hypothalamic paraventricular nucleus (PVN) 4 days before stress as well as by pretreatment with a rabbit antiserum to adrenocorticotropin (ACTH) 30 min before stress. RU-38486 (10 mg/kg po) was administered 20 min before and 60 min after the onset of stress. Corticosterone for replacement was injected 15 min before the onset of stress to mimic stress-induced corticosterone response. Plasma corticosterone levels were measured by fluorometry or RIA. Gastric erosions were quantitated by measuring the area of damage. Four days after PVN lesion, stress-induced corticosterone release was decreased and gastric erosions were increased. Injecting corticosterone significantly attenuated the effect of PVN lesion on gastric erosions. The ACTH antiserum inhibited corticosteroid secretion in response to stress and markedly increased gastric erosions. The administration of the glucocorticoid/progesterone antagonist RU-38486 significantly potentiated the formation of stress-induced gastric erosions. These observations support the suggestion that glucocorticoids released during stress have a gastroprotective action rather than an ulcerogenic effect as was generally accepted.
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Dissertations / Theses on the topic "Corticosterone"

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Assis, Vania Regina de. "Relação entre os níveis plasmáticos de corticosterona e testosterona no comportamento vocal e territorial no sapo martelo (Hypsiboas faber)." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-14022011-200502/.

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A partir de estudos sobre o controle endócrino do comportamento reprodutivo em anuros sabemos que diversos aspectos do comportamento vocal e das interações agonísticas nestes animais encontram-se associados a alterações dos níveis hormonais de testosterona e corticosterona. Dentre as espécies de anuros neotropicais de grande interesse para estudos a respeito do controle endócrino do comportamento reprodutivo destaca-se Hypsiboas faber, uma espécie de hilídeo caracterizada pela presença de machos territorialistas, cujas interações agonísticas abrangem uma diversidade de padrões vocais com agressividade escalar, podendo culminar em embate físico, além da construção de ninhos para oviposição e comportamento facultativo de guarda deste ninho. O objetivo deste trabalho foi entender as inter-relações entre os níveis plasmáticos de corticosterona e testosterona, e os comportamentos de vocalização e defesa territorial em machos de H. faber durante a atividade reprodutiva. Tais interrelações foram investigadas através da observação do comportamento durante as atividades vocais, seguidas de coleta de sangue para dosagem hormonal. Contamos adicionalmente com uma abordagem experimental, que consistiu no uso de gravações do coaxo de anúncio (playback), simulando a invasão de outro macho no território dos indivíduos focais, seguida de observação comportamental e coleta de sangue para dosagem hormonal. O estímulo experimental não surtiu qualquer efeito sobre os níveis plasmáticos de corticosterona e testosterona, nem sobre a maior parte das variáveis comportamentais. Conseguimos identificar um padrão de variação sazonal nos níveis de corticosterona e testosterona, bem como uma correlação positiva entre estes hormônios. Adicionalmente, indivíduos que vocalizam a taxas mais altas apresentam níveis mais elevados de corticosterona durante o início da temporada reprodutiva, enquanto níveis mais elevados de testosterona aparecem nos indivíduos mais responsivos a estímulos provindos do entorno social.
From studies on the endocrine control of reproductive behavior in anurans, we know that many aspects of vocal behavior and agonistic interactions of these animals are related to changes in plasma levels of testosterone and corticosterone. Among the species of neotropical frogs of great interest for studies on the endocrine control of reproductive behavior stands out Hypsiboas faber, a hylid characterized by the presence of territorial males, whose agonistic interactions cover a variety of vocal patterns with aggressiveness scale, which may culminate in physical conflict. Males of H. faber also build nests for oviposition and presents optional guard of the nests with eggs. The aim of this study was to understand the interrelationships between plasma levels of corticosterone and testosterone with calling behavior and territorial defense in males of H. faber during reproductive season. These relationships were investigated by focal observations during the vocal activities, followed by blood sampling for hormonal assay. We additionally used an experimental approach, which consisted of using recorded advertisement calls (playback), simulating an invasion of another male in the territory of the focal subjects, followed by behavioral observation and blood sampling for hormonal assay. The experimental stimulus had no effect on plasma levels of corticosterone and testosterone, neither on the majority of behavioral variables. We can identify a pattern of seasonal variation in levels of corticosterone and testosterone, as well as a positive correlation between these hormones. Additionally, individuals who vocalize at higher rates have higher levels of corticosterone during the beginning of reproductive season, while higher levels of testosterone appear in individuals more responsive to stimuli from the social environment.
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Sampaio, Valdomiro de Freitas. "Efeitos da desnutrição protéica precoce e da estimulação ambiental sobre parâmetros bioquímicos e comportamentais em ratos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-27082009-120622/.

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O presente estudo investigou os efeitos da desnutrição protéica e estimulação ambiental sobre parâmetros bioquímicos em ratos. Foram quantificadas as concentrações de poliaminas no córtex frontal, estriado e hipocampo, corticosterona plasmática e atividade da sintase do óxido nítrico no hipocampo. O comportamento exploratório foi analisado no labirinto em cruz elevado (LCE). Os animais receberam dietas contendo 16% (controles - C) ou 6% (desnutridos - D) de proteína e foram divididos em grupos estimulados ou não estimulados. A desnutrição elevou o nível de corticosterona circulante, diminuiu o conteúdo protéico plasmático e diminuiu a ansiedade. Os ratos não estimulados testados no LCE apresentaram nível elevado de corticosterona circulante, diminuída atividade da NOS no hipocampo, menor conteúdo protéico e de poliaminas no córtex frontal, estriado e hipocampo. A estimulação diminuiu o número de entradas nos braços abertos no LCE nos animais do grupo D e aumentou o número de entradas nos braços fechados nos animais do grupo C. A estimulação aumentou a frequência e tempo gasto em comportamentos de avaliação de risco. Estes resultados sugerem que ambos, a desnutrição e o teste no LCE são situações estressantes, como indicado pela elevação dos níveis de corticosterona. Estes resultados são consistentes com menor ansiedade e/ou maior impulsividade nos animais do grupo D.
The present study investigated the effects of protein malnutrition and environmental stimulation on the biochemical and behavioral parameters in rats. It was measured the polyamines concentration in frontal cortex, striatum and hippocampus, as well as the plasma corticosterone levels. The exploratory behavior was analyzed using the elevated plus-maze (EPM) test. Rats received either 16% (well-nourished - W) or 6% (malnourished - M) protein diets and were divided into stimulated or non-stimulated groups. Malnutrition increased corticosterone levels, decreased plasma protein content and anxiety. Non-stimulated rats tested in the EPM increased corticosterone levels, decreased hippocampal NOS activity, decreased frontal cortex, striatum and hippocampus protein and polyamines contents. Stimulation decreased open arm entries in the EPM in M animals and increased the closed arm entries in the W ones. Stimulation increased frequency and time spent in risk-assessment behaviors. These results suggest that both malnutrition and EPM testing are stressing situations as indicated by increased corticosterone levels. These results are consistent with lower anxiety and/or higher impulsiveness in M animals.
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Contarteze, Ricardo Vinicius Ledesma [UNESP]. "Biomarcadores do estresse em ratos exercitados por natação e corrida em esteira rolante." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/87423.

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Made available in DSpace on 2014-06-11T19:22:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-04-20Bitstream added on 2014-06-13T18:08:43Z : No. of bitstreams: 1 contarteze_rvl_me_rcla.pdf: 244333 bytes, checksum: bb439309fd00a352f846a3b4aad3fa24 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Muitos estudos enfocando metabolismo e exercício são desenvolvidos em modelos animais, especialmente os ratos. Entre os exercícios mais utilizados nas pesquisas com animais estão a esteira rolante e a natação. Contudo, ainda persistem dúvidas de qual seria o exercício mais apropriado para desencadear mais respostas ao exercício e menos respostas associadas a outros estresses. A atividade do eixo hipotálamo-hipófise-adrenal constituído pelos hormônios ACTH e corticosterona são importantes biomarcadores de estresse. Portanto, o objetivo do presente estudo foi comparar biomarcadores do estresse durante exercício de intensidade conhecida em ratos exercitados por natação e por corrida em esteira rolante. Foram utilizados ratos Wistar adultos, adaptados aos exercícios, que tiveram a máxima fase estável de lactato (MFEL) determinada. Para isso, foram submetidos a 3 testes de 25 minutos de exercícios de natação (n=18) suportando cargas de 5,0 ; 5,5 e 6,0% do peso corporal (PC) ou 3 corridas com 25 minutos de duração (n=13) às velocidades de 15; 20 e 25 m/min. Houve coleta sangüínea da extremidade da cauda dos ratos a cada 5 minutos de exercício para dosagem de lactato. Após obtenção da MFEL, os animais foram divididos em subgrupos: (M) sacrificados imediatamente após sessão de 25 minutos de exercício (natação=09 ou esteira=07) na intensidade da MFEL ou (S) sacrificado após exercício exaustivo (natação=09 ou esteira=06) em intensidade 25% superior a MFEL. Para comparações, um grupo controle C (n=10) foi sacrificado em repouso. Utilizou-se Anova Two Way para identificar possíveis diferenças nos parâmetros de estresse (p<0,05). Foram obtidos os seguintes resultados MFEL: natação 5,5% do PC e corrida 20m/min às concentrações de lactato sanguíneo (mmol/L) de 5,2l0,3 na natação e 3,8l0,1 na corrida...
Many studies on metabolism and exercise are developed with animal models especially rats. Treadmill running and swimming are among the exercises most used in researches involving animals. However, doubts on which would be the most suitable exercise to unchain more responses to exercise and less responses associated to other stresses still remain. The activity of the hypothalamic-pytuitary-adrenal axis composed of ACTH and corticosterone hormones are important stress biomarkers. Therefore, the objective of the present study was to compare stress biomarkers during known-intensity swimming and treadmill running exercises performed by rats. Wistar adult rats previously adapted to exercises and with their maximum lactate steady state (MLSS) determined were used. To do this, rats were submitted to 3 swimming tests with 25 minutes of duration (n=18) with loads of 5.0; 5.5 and 6.0% of their body weight (BW) or to 3 running sessions with 25 minutes of duration (n=13) at velocities of 15; 20 and 25 m/min. Blood samples were collected from the tip tail of rats each 5 minutes of exercise for lactate dosage. After MLSS attainment, the animals were divided into the following subgroups: (M) sacrificed shortly after session of 25 minutes of exercise (swimming=09 or treadmill=07) at the MLSS intensity or (S) sacrificed after exhaustive exercise (swimming=09 or treadmill=06) at intensity 25% above MLSS. For comparison purposes, a control group C (n=10) was sacrificed in rest. The Two-Way ANOVA was used in order to identify possible differences in the stress parameters (P<0.05). The following results were obtained: MLSS: swimming 5.5% of the BW and treadmill running at 20 m/min at blood lactate concentrations (mmol/L) of 5.2l0.3 in swimming and of 3.8l0.1in running. Serum ACTH concentrations (pg/mL) were significantly higher for the swimming group (963.3l420.4)... (Complete abstract, click electronic address below)
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Filho, Procópio Cleber Gama de Barcellos. "Efeitos da corticosterona e do estrógeno na atividade do eixo HPA de ratas: comportamento e comprimento dos telômeros." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-13092018-141304/.

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O estresse crônico promove diversas alterações no funcionamento de um organismo. O aumento de glicocorticoides pode interferir no estado físico e psicológico de um individuo. Trabalhos recentes correlacionam estresse psicossocial crônico à redução do comprimento dos telômeros de determinadas células. E o estrógeno, além de ser um fator modulador da atividade do sistema de estresse, também pode interferir no comprimento dos telômeros. O objetivo desse trabalho foi verificar se a exposição crônica aos glicocorticóides promove alterações no comprimento dos telômeros de áreas encefálicas envolvidas no controle da atividade do eixo Hipotálamo-Hipófise-Adrenal (HPA) e em respostas comportamentais de ratas, e se o estrógeno pode modular essas alterações. Ratas Wistar ovariectomizadas foram tratadas com cipionato de estradiol (50 ou 100 µg/kg, s.c.) ou óleo, e submetidas à administração de corticosterona 20 mg/Kg ou veículo (salina isotônica 2% Tween 80, s.c.), durante 28 dias. No 25 º dia os animais foram submetidos ao teste do nado forçado, e no 27º dia, ao teste de labirinto em cruz elevado. No dia subsequente ao término do tratamento hormonal, os animais foram eutanasiados para coleta do sangue, cérebro e hipófise. O tratamento com cipionato de estradiol causou: aumento das concentrações plasmáticas de corticosterona e progesterona; redução da expressão de mRNA para CRH, AVP e POMC no PVN; um efeito ansiolítico a avaliado pelo teste do labirinto em cruz elevado; . um efeito depressivo indicado pelo teste de nado forçado; reduziu o tamanho dos na amígdala central e hipocampo dorsal, mas não no PVN. A corticosterona causou: redução da secreção de gonadotrofina; redução da expressão de RNA mensageiro para CRH e POMC e aumento para AVP no PVN; um efeito depressivo indicado pelo teste de nado forçado. O conjunto de resultados mostra que modificação na atividade do eixo HPA e a variação das concentrações plasmáticas de estrógeno podem provocar diversas alterações de ações hormonais, atividades comportamentais e de estrutura do DNA em áreas cerebrais.
Chronic stress promotes several changes in the functioning of an organism. Increased glucocorticoids may interfere with an individual\'s physical and psychological state. Recent works correlate chronic psychosocial stress to the reduction of the telomere length of certain cells. And estrogen, besides being a modulating factor of the activity of the stress system, can also interfere in the length of telomeres. The objective of this study was to verify if chronic exposure to glucocorticoids promotes changes in telomere length of encephalic areas involved in the control of hypothalamic-hypophysis-adrenal (HPA) axis activity and in rat behavioral responses, and whether estrogen can modulate these changes. Ovariectomized Wistar rats were treated with estradiol cypionate (50 or 100 ?g / kg, s.c.) or oil, and given 20 mg / kg corticosterone or vehicle (isotonic saline 2% Tween 80, s.c.) for 28 days. On the 25th day the animals were submitted to the forced swim test, and on the 27th day, the elevated plus maze test. On the day after the end of the hormonal treatment, the animals were euthanized for collection of blood, brain and pituitary gland. Treatment with estradiol cypionate caused: increased corticosterone and progesterone plasma concentrations; reduction of mRNA expression for CRH, AVP and POMC in PVN; an anxiolytic effect as assessed by the elevated plus maze test. A depressive effect indicated by the forced swim test; reduced size in the central amygdala and dorsal hippocampus, but not in PVN. Corticosterone caused: reduction of gonadotrophin secretion; reduction of mRNA expression for CRH and POMC and increase for AVP in PVN; a depressive effect indicated by the forced swim test. The set of results shows that changes in HPA axis activity and variation in plasma estrogen concentrations can lead to several changes in hormonal actions, behavioral activities and DNA structure in brain areas.
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Long, Jennifer A. "Hormonal and Cellular Mechanisms of Fattening in Migratory Songbirds." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/LongJA2007.pdf.

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Yang, Silei. "Rapid neuronal signaling cascades initiated by corticosterone." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-148762.

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Moraes, José Evandro de. "Indicadores de bem-estar de linhagens de poedeiras comerciais leves alojadas em cinco densidades no sistema convencional de produção de ovos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-04122018-095337/.

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Foram utilizadas 750 poedeiras comerciais de linhagens brancas com 23 semanas ao início do período experimental, distribuídas num delineamento em blocos completos aleatorizados sendo estes caracterizados pela oncatenação das linhagens com coluna de gaiolas; os tratamentos foram cinco densidades ou taxas de lotação na gaiola (321,43; 375; 450; 562,50 e 750 cm2/ave) com seis repetições, totalizando 150 parcelas experimentais. As dietas experimentais foram à base de milho e farelo de soja, formuladas para suprir as exigências nutricionais das linhagens em todas as fases. O desempenho produtivo e econômico foram avaliados através do peso dos ovos (g), percentagem de postura (%), massa de ovos (g/ave/dia), consumo de ração (g/ave/dia), conversão alimentar por dúzia (kg/dz) e por quilo de ovo (kg/kg). A qualidade de ovos foi avaliada através da gravidade específica (GE), unidades Haugh (UH), percentagens de gema, albúmen e casca, espessura da casca (EC), resistência à quebra (RQ), coloração da gema e índice gema (IG). O bem-estar das aves foi avaliado através de indicadores clínicos, imunológicos e fisiológicos. Para efeito da avaliação dos resultados, foram estabelecidos seis blocos com repetições internas. Os dados foram analisados com auxílio do SAS, sob modelo misto, considerando os efeitos da densidade, período e a interação entre estes, como fixos, além dos efeitos aleatórios de bloco e resíduo. Por se tratar de medidas repetidas longitudinalmente, buscou-se a melhor estrutura de covariância para cada variável. Quando adequado foi aplicado o teste de tukey-kramer para a comparação de médias (p<0,05). O menor consumo de ração, CA/dz de ovos e melhor desempenho econômico, foram obtidos pela densidade 321,4 cm2/ave. Altas densidades de alojamento não influenciaram a qualidade interna de ovos, a % casca e RQ, mas essas variáveis tiveram efeitos dos períodos, com os melhores valores nos primeiros períodos. Altas densidades tiveram efeitos negativos sobre a GE e EC, principalmente no pico de postura das aves. Os ovos avaliados encontravam-se dentro dos valores desejados, mesmo nas maiores densidades, podendo ser classificados como de excelente qualidade. A densidade de alojamento não interferiru (p>0,05) na avaliação clínica das aves, mas o maior espaço proporcionado nas gaiolas do sistema covencional conferiu menor freqüência de lesões nas aves, indicando promoção e melhora ao seu bem-estar geral. Dados de freqüência cardíaca e temperatura da cloaca estavam dentro dos padrões de normalidade para a espécie. Não foram observadas diferenças (p>0,05) das densidades na resposta imunológica das aves, com os títulos dos anticorpos vacinais contra as doenças de Gumboro e Newcastle acima dos níveis do ponto de corte (cutoff). Os tratamentos não modificaram o perfil sanguíneo das aves e não foi possível caracterizar um padrão de corticosterona no plasma e de excreção de metabólitos fecais de glicocorticoides. A técnica de enzimoimunoensaio, empregada utilizando anticorpo primário contra corticosterona e anticorpo secundário anticoelho de cabra, foi capaz de detectar as variações nas concentrações de corticosterona nesses tecidos, contudo, o entendimento do significado desses achados ainda necessita de novas investigações.
750 commercial laying hens of white strains aged 23 weeks at the beginning of the experimental period were used, distributed in a randomized complete block design, these being characterized by the concatenation of the strains with column of cages; the treatments were five densities or stocking rates in the cage (321,43, 375, 450, 562.50 and 750 cm2/bird) with six replications, amounting to 150 experimental plots. The experimental diets were on the basis of corn and soybean meal, formulated to meet the nutritional requirements of the strains in all the phases. Both the productive and economic performances were evaluated through the weight of the eggs (g), percentage of laying (%), egg mass (g/bird/day), feed intake (g/bird/day), feed conversion per dozen (kg/dozen) and per kg of egg (kg/kg). Egg quality was determined through specific gravity (SG), Haugh units (HU), percentages of yolk, albumen and shell, shell thickness (ST), resistance to breaking (BR), yolk coloration and yolk index (YI). The welfare of the birds was evaluated through clinical, immunological and physiological indicators. For the purpose of evaluation of the results, six blocks with internal replications were established. The data were analyzed with the aid of SAS, under a mixed model, considering the effects of density, period and the interaction between them, as fixed, in addition to the random effects of block and residue. For se tratar de measures longitudinally repeated, the best covariance structure for each variable was sought. When appropriate, the Tukey-Kramer test was used for comparison of means (p<0.05). The lowest feed intake, FI/dozen of eggs and best economic performance, were obtained at the density of 321.4 cm2/bird. High housing densities did not influence the internal quality of the eggs, % shell and BR, but these variables had effects from the periods, with the best values in the early periods. High densities had negative effects on SG and ST, mainly at the laying peak of the birds. The eggs checked lie within the desired values, even at the highest densities and can be classified as of excellent quality. The housing density did not interfere (p>0.05) in the clinical evaluation of the birds, but the greater space provided in the cages of the conventional system conferred a lower frequency of lesions in the birds, indicating promotion and improvement to their general welfare. Data of heart rate and cloacal temperature were within the normal limits for the species. No differences (p>0.05) of the densities in the immune response of the birds, with the titers of the vaccine antibodies against Gumboro and Newcastle diseases above the cutoff levels were found. The treatments did not modify the blood profile of the birds and it was not possible to characterize a standard of plasma corticosterone and excretion of fecal metabolites of glucocorticoids, but the enzyme immunoassay technique, using primary antibody against corticosterone and secondary goat anti-rabbit antibody, was capable of detecting variations in the corticosterone concentrations in these tissues, however, the understanding of the meaning of these findings still requires further investigation.
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Assis, Vania Regina de. "Níveis plasmáticos de corticosterona, testosterona e imunocompetência em Bufonídeos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-14012016-151309/.

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Glicocorticóides modulam a resposta imune de forma complexa em vertebrados expostos a diferentes estressores. Dado que as populações naturais têm estado expostas a uma multiplicidade de estressores, uma melhor compreensão da associação funcional entre a duração e a intensidade da resposta ao estresse, as mudanças resultantes nos níveis dos hormônios esteróides e seu impacto sobre os diferentes aspectos da imunocompetência emergem como um ponto chave para as estratégias de conservação dos vertebrados. Nós investigamos as relações entre os níveis plasmáticos de hormônios esteróides e a imunocompetência inata em anfíbios anuros, incorporando as metodologias de desafio de contenção, elevação experimental dos níveis de corticosterona por aplicação transdérmica, capacidade bactericida por espectrofotometria e o desafio imunológico com fitohemaglutinina. Nossos resultados demonstram que a capacidade bactericida plasmática (CBP) medida por espectrofotometria é um método confiável e preciso para estimar a imunocompetência de anfíbios anuros, além disso, mostramos a existência de uma grande diversidade interespecífica na CBP de anuros machos. Quando quatro diferentes espécies de Bufonídeos foram submetidas a um desafio de contenção, as respostas gerais incluíram aumento dos níveis plasmáticos de corticosterona (CORT) e da relação neutrófilo/linfócito (N:L) e diminuição dos níveis plasmáticos de testosterona (T). As respostas da CBP à contenção foram muito mais variáveis, com R. ictérica mostrando diminuição e R. marina mostrando aumento dos valores de CBP. Adicionalmente, CORT e N:L tenderam a aumentar mais em resposta à contenção com restrição de movimento do que à contenção sem restrição de movimento, indicando que os sapos demostraram um aumento da resposta ao estresse quando submetidos ao estressor mais intenso. Todas as variáveis estudadas mostraram variação interespecífica. Rhinella ornata apresentou os maiores níveis basais de CORT quando comparado com as outras espécies, enquanto R. ornata e R. ictérica mostraram os maiores valores basais de CBP. Entretanto, as mudanças na relação N:L, nos níveis de T e na CBP, não foram correlacionadas com o aumento em CORT, dentro ou entre espécies. A aplicação transdérmica de corticosterona eficientemente simulou eventos repetidos de resposta ao estresse agudo em Rhinella ictérica, sem alterar os parâmetros imunitários, mesmo após treze dias de tratamento. Curiosamente, o cativeiro a longo prazo não atenuou a resposta ao estresse, uma vez que estes sapos mantiveram um aumento de três vezes em CORT mesmo depois de três meses sob estas mesmas condições. Além disso, a manutenção em cativeiro a longo prazo, nas mesmas condições, aumentou a contagem total de leucócitos (TLC) e gerou uma diminuição ainda maior na CBP, sugerindo que as consequências da resposta ao estresse podem ser agravadas pelo tempo em cativeiro. Com base em nossos resultados, consideramos que uma avaliação cuidadosa é necessária para compreender a modulação da resposta imunitária pelo estresse a nível intra e interespecífico. A inclusão de diferentes segmentos da resposta imune é desejável, e a padronização da coleta de dados para todas as espécies sob o mesmo período (em geral, dentro ou fora da época reprodutiva) e mesma atividade (em geral, vocalizando ou forrageando) se faz obrigatória
Glucocorticoids modulate the immune response in complex ways in vertebrates exposed to different stressors. Given that natural populations have been exposed to a multitude of stressors, a better understanding of the functional association between duration and intensity of the stress response, the resulting changes in steroid hormone levels and their impact on different aspects of immunocompetence emerges as a cornerstone for vertebrate conservation strategies. We investigated the relationships between steroids levels and innate immunocompetence in anuran amphibians, incorporating the methodology of restraint challenge, experimental elevation of corticosterone levels by transdermal application, bacterial killing ability by spectrophotometry and the immune challenge with phytohemagglutinin. Our results demonstrate that the bacterial killing ability (BKA) measured by spectrophotometry is a reliable and accurate method to estimate the immunocompetence of anuran amphibians, additionally showed the existence of a large interspecific diversity in BKA from male anurans. When four different species of Bufonids were submitted to a restraint challenge, the general responses included increased in corticosterone plasma levels (CORT) and neutrophil/lymphocyte ratio (N:L) and decreased in testosterone plasma levels (T). The responses of BKA to restraint were much more variable, with R. icterica showing decreased and R. marina showing increased values. Additionally, CORT and N:L tended to increase more in response to restraint with movement restriction than to restraint without movement restriction, indicating that toads showed an increased stress response to the more intense stressor. All variables studied show interspecific variation. Rhinella ornate showed higher baseline CORT when compared to other species, while R. ornate and R. icterica showed the highest baseline BKA values. However, changes in N:L ratio, T levels and BKA, were not correlated to increased CORT within or between species. Transdermal application of corticosterone efficiently mimics repeated acute stress response events in Rhinella icterica, without changing the immune parameters even after thirteen days of treatment. Interestingly, long-term captivity did not mitigate the stress response, since the toads maintained three fold increased CORT even after three months under these conditions. Moreover, long-term captivity in the same condition increased total leukocyte count (TLC) and generated an even greater decrease in BKA, suggesting that consequences of the stress response can be aggravated by time in captivity. Based on our results, we consider that a careful evaluation is necessary in order to understand the modulation of the immune response by stress at intra and interspecific levels. The inclusion of different segments of the immune response is desirable, and a standardized data collection for all the species under the same period (e.g. inside or outside of breeding season) and same activity (e.g. calling or foraging) is mandatory
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Barsotti, Adriana Maria Giorgi. "Modulação dos níveis plasmáticos de corticosterona e imunocompetência em resposta ao tratamento exógeno com ACTH em Hypsiboas faber." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-19032015-134658/.

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Em resposta a diversos estressores, o hipotálamo de anfíbios secreta o hormônio liberador de corticotropina (CRH), o qual estimula a hipófise a liberar o hormônio adrenocorticoctrópico (ACTH) na corrente sanguínea. O ACTH, por sua vez, atua na glândula inter-renal estimulando a liberação de glicocorticoides, sendo a corticosterona o principal glicocorticoide em anfíbios. Embora a modulação exercida pelos glicocorticoides de diversas respostas fisiológicas de estresse seja fundamental para a manutenção da homeostase em curto prazo, a ativação muito frequente e/ou prolongada do eixo hipotálamo-hipófise-interrenais (HHI) pode inibir processos importantes em longo prazo, tais como a reprodução e a imunocompetência e afetar a síntese de melatonina atuando diretamente sobre a pineal. O objetivo do presente estudo foi avaliar possíveis alterações nos níveis plasmáticos de corticosterona, testosterona, níveis oculares de melatonina, hematócrito e aspectos imunitários (contagem total de leucócitos e capacidade antimicrobiana plasmática - contra Escherichia coli) de machos da perereca Hypsiboas faber em resposta à injeção de ACTH, bem como o curso temporal destas respostas. Amostras de sangue e plasma foram obtidas a partir de 30 machos capturados em campo, dentro de 3 minutos da captura. Os animais foram trazidos para o laboratório e, após dois meses, divididos em seis grupos para serem amostrados em três horários distintos 1 h, 3h e 6h após o tratamento. Para cada horário um grupo controle e um grupo experimental foram adicionados, recebendo uma injeção de 105 μL de solução salina ou de solução de ACTH (0,446 μg de ACTH/g de massa corpórea (grupo experimental)). O tratamento com ACTH aumentou significativamente os níveis plasmáticos de corticosterona e diminuiu os níveis plasmáticos de testosterona bem como os níveis oculares de melatonina após 1 hora. Após 6 h da injeção de ACTH, houve um aumento da porcentagem do hematócrito e dos níveis de melatonina ocular. O tratamento com ACTH não afetou os aspectos imunitários estudados dentro do intervalo amostrado. Os resultados confirmam o papel da ativação do eixo HHI na inibição da secreção de testosterona e na modulação da secreção de melatonina, embora os possíveis efeitos imunomodulatórios possam se dar em intervalos temporais mais tardios
In response for several stressors, the amphibian hypothalamus release the corticotrophin release hormone (CRH), which stimulates pituitary to release the adenocorticotropic hormone (ACTH) in the bloodstream. The ACTH, in your turn, acts in inter renal glands stimulating the glicocorticoids releasing, being the corticosterone the main glicocorticoid in anphibians. While the modulation exercised by the glicocorticoids of diverses physiological responses of the stress is fundamental for de maintainance of homeostasis in short period, the frequent and/or prolongued activation of the hypothamlamus pituitary interenal axis (HHI) could inhibit important process in long periods, as the reproduction and immunocompetence and affect melatonin synthesis acting directly in pineal gland. The objective of the present study was evaluate possible alterations in plasmatic corticosterone levels, testosterone, eyes melatonin levels, hematocrit and immunity aspects (Total count leucocytes and antimicrobian plasmatic capacity - against Escherichia coli) from males of the treefrog Hypsiboas faber in response to ACTH injection, as well, the temporal course of these responses. Blood and plasma samples were obtained from the 30 males captured in the field, whitin 3 minutes from the capture. The animals were transferred to the laboratory and, after two months, divided in six groups to be sampled in three different times 1 h, 3 h and 6 h after treatment. For each time one control group and one experimental group were added, receiving one injection of 105 μL of saline or ACTH solution (0,446 μg de ACTH/g of body mass (experimental group)). The ACTH treatment increase significantly the plasmatic corticosterone levels and decrease the plasmatic testosterone levels, as well, the eye melatonin levels after one hour. After six hours of the ACTH injection, occurred the increase of the hematocrit percentage and the eye melatonin levels. The ACTH treatment did not affect the immunity aspects studied in the sampling interval. The results confirm the role of the activation on the axis HHI in the inhibition of the testosterone secretion and in the modulation of melatonin secretion, althougth the possible immunomodutatory effects could happen in temporal intervals later
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Sá-Rocha, Vanessa de Moura. "Aspectos neuroimunes de camundongos mantidos em uma relação social estável." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-23032007-183834/.

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O objetivo do presente trabalho foi investigar as repercussões de uma relação social estável sobre diferentes parâmetros de comportamento, neuroquímica e atividade imune de camundongos dominantes e submissos. Machos adultos (com aproximadamente 90 dias de idade) mantidos em duplas desde o desmame, foram determinados como dominantes ou submissos, após três avaliações consecutivas do comportamento, onde foram observadas a presença ou ausência de ataques ou fugas e posturas de submissão. Em alguns experimentos, grupos de cinco animais mantidos em uma mesma caixa foram utilizados para comparação com resultados obtidos de animais que conviveram em duplas. Foram utilizadas apenas as duplas de camundongos onde a hierarquia social foi claramente observada. Os resultados mostraram que os animais submissos apresentaram em relação aos dominantes: 1) diminuição no tempo gasto na zona central do campo aberto; 2) diminuição no número de entradas nos braços abertos e diminuição no tempo gasto na exploração dos braços abertos do labirinto em cruz elevado; 3) aumento no tempo gasto na exploração dos braços fechados do labirinto em cruz elevado; 4) diminuição no número de entradas e no tempo gasto na exploração do terço final dos braços fechados do labirinto em cruz elevado; 5) aumento na taxa de renovação de dopamina no hipotálamo; 6) diminuição da taxa de renovação de dopamina no corpo estriado; 7) maior número de metástases induzidas pelo melanoma murino experimental B16F10; 8) aumento do percentual de células T CD8+ no timo após 14 dias de inoculação do mesmo melanoma; 9) diminuição no burst oxidativo basal de neutrófilos e monócitos sangüíneos, mas não naquele induzido por bactérias; 10) menor atividade de células NK presentes no baço e no sangue. Em relação aos animais mantidos em número de cinco, os animais submissos apresentaram: menor percentual de células NK no sangue. Já os animais dominantes, apresentaram em relação aos animais mantidos em grupos: 1) aumento da taxa de renovação de noradrenalina no hipotálamo; 2) aumento na taxa de renovação de dopamina no corpo estriado; 3) menor percentual de células NK no sangue. O status social, no entanto, não provocou diferenças: 1) nos níveis absolutos de dopamina, noradrenalina e serotonina; 2); nos metabólitos de serotonina; 3) nos níveis séricos basais de corticosterona; 4) no peso e número de células do baço e timo; 5) no percentual de células T CD4+ e CD8+ no baço e 6) no percentual de linfócitos, neutrófilos e monócitos sangüíneos. Em conjunto, os presentes resultados mostraram que animais dominantes e submissos mantidos por 90 dias em uma hierarquia social estável, apresentaram diferenças comportamentais e neuroquímicas, e responderam de forma diferente a um mesmo estímulo imune, no caso, o desenvolvimento de metástases induzida nos pulmões pela administração do melanoma experimental murino B16F10. Estes resultados sugerem que diferentes mecanismos, que não a ativação do eixo HPA, estejam envolvidos com o aumento de susceptibilidade ao desenvolvimento do tumor observado nos indivíduos submissos
The objective of the present work was to investigate the repercussions of a stable social relationship on different parameters of the behavior, neurochemical and immune activity of dominant and submissives mice. Adult males (with approximately 90 days of age) kept in pairs since wean it, had been determined as dominant or submissives, after three consecutive evaluations of the behavior, where presences or absences of attacks or escapes and positions of submission had been observed. In some experiments, groups of five animals kept in one same box had been used to compare the results gotten between these and the animals coexisting in pairs. The pairs had been used only where the social hierarchy clearly was observed. The results had shown that the submissives animals in relation to the dominant ones had presented: 1) reduction in the time spent in the central zone of the open field; 2) reduction in the number of entrances in the open arms and reduction in the time spent in the exploration of the open arms of the plus maze; 3) increase in the time spent in the exploration of the closed arms of the plus maze; 4) reduction in the number of entrances and time spent in the exploration of the final third of the closed arms of the plus maze; 5) increase in the turnover of dopamine in the hypothalamus; 6) reduction in the turnover of dopamine in the corpus striatum; 7) increased number of metastasis in the lungs induced by murino melanoma experimental B16F10; 8) increase of the percentage of cells T CD8+ in the thymus after 14 days of inoculation of the same melanoma; 9) reduction in the basal oxidative burst of neutrophil and monocytes sanguine, but not in the induced by bacteria; 10) decreased NK cells activity measured in the blood and spleen. In relation to the animals kept in number of five, the submissives animals had presented: 11) reduction in the percentile of NK cells in the blood. While the dominant animals had presented in relation to the animals kept in groups: 1) increase in the turnover of norepinephrine in hypothalamus; 2) increase in the turnover of dopamine in the fluted body; 3) reduction in the percentile of NK cells in the blood. The social status, however, did not provoke differences: 1) in the absolute levels of dopamine, norepinephrine and serotonin; 2) in the metabolites of serotonin; 3) in the serum levels of corticosterone; 4) in the weight and number of cells of the spleen and thymus; 5) in the percentage of cells T CD4+ and CD8+ in the spleen and 6) in the percentage of lymphocytes, neutrophil and monocytes in the blood. Together, the results obtained had shown that dominants and submissives animals kept 90 days living in a stable social hierarchy had presented behavior and neurochemical differences, and had answered of different form to one same immune stimulation, in this case, the induced development of metastasis in the lungs for experimental melanoma murino B16F10, where the submissives had been more susceptible than the dominant ones. This results suggest that other mechanisms, different of HPA activation, may be involved with the decreased resistance of submissive mice to B16F10 tumor dissemination
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Books on the topic "Corticosterone"

1

Lanctot, Richard Benjamin. Are corticosterone levels a good indicator of food availability and reproductive performance in a kittiwake colony? Anchorage, Alaska: EVOS Trustee Council, 2003.

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Shum, Kar Man Kathy. Effects of antecedent hypoglycemia, antecedent hyperinsulinemia, and antecedent corticosterone on subsequent counterregulation in normal rats. Ottawa: National Library of Canada, 2000.

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Harrison, Amanda J. The effects of increased corticosterone levels and auditory stress on food consumption in female wistar rats. Sudbury, Ont: Laurentian University, 2006.

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N, Lin Andrew, and Paget Stephen A, eds. Principles of corticosteroid therapy. London: Arnold, 2002.

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de, Kloet E. R., Azmitia Efrain C, Landfield Philip W, and New York Academy of Sciences., eds. Brain corticosteroid receptors: Studies on the mechanism, function, and neurotoxicity of corticosteroid action. New York, N.Y: New York Academy of Sciences, 1994.

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Parker, James N., and Philip M. Parker. The official patient's sourcebook on antenatal corticosteroid therapy. Edited by Icon Group International Inc and NetLibrary Inc. San Diego, Calif: Icon Health Publications, 2002.

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Griffiths, Mark Raymond. Phencyclidine-and corticosteroid-induced apoptosis of striatal neurons. Birmingham: University of Birmingham, 1999.

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Enno, Christophers, ed. Topical corticosteroid therapy: A novel approach to safer drugs. New York: Raven Press, 1988.

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Verfasser, Kley Hans Kuno, ed. Cortisontherapie: Corticoide in Klinik und Praxis. 9th ed. Stuttgart: Thieme, 1992.

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Näsström, Karin. Dentin formation after corticosteroid treatment: A clinical study and an experimental study on rats. Malmö, Sweden: Department of Oral Radiology, Faculty of Odontology, Lund University, 1996.

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Book chapters on the topic "Corticosterone"

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Chakraborty, Arijit. "Corticosterone." In Encyclopedia of Animal Cognition and Behavior, 1–5. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-47829-6_1336-1.

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Chakraborty, Arijit. "Corticosterone." In Encyclopedia of Animal Cognition and Behavior, 1729–33. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-55065-7_1336.

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Schomburg, Dietmar, and Dörte Stephan. "Corticosterone 18-monooxygenase." In Enzyme Handbook, 669–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57942-4_142.

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Fathi, Mobina, and Nima Rezaei. "Corticosterone Methyloxidase Deficiency." In Genetic Syndromes, 1–4. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-319-66816-1_1820-1.

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Herbert, Joe, and Scarlet Bella Pinnock. "Corticosterone, Dehydroepiandrosterone, and Neurogenesis in the Adult Hippocampus." In Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis, 347–65. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633968.ch20.

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Gourley, Shannon L., and Jane R. Taylor. "Induction of Persistent Depressive-Like Behavior by Corticosterone." In Mood and Anxiety Related Phenotypes in Mice, 251–65. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-313-4_16.

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Guest, Paul C. "A Protocol for Generation of a Corticosterone Model of Psychiatric Disorders." In Advances in Experimental Medicine and Biology, 263–68. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52479-5_24.

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Ramírez, Francisco, and Don Mason. "Corticosterone and the hypothalamic-pituitary-adrenal (HPA) axis in autoimmune diseases." In Steroid Hormones and the T-Cell Cytokine Profile, 153–67. London: Springer London, 1997. http://dx.doi.org/10.1007/978-1-4471-0931-0_7.

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Fuller, R. W. "Antagonism of Serotonin Agonist-Elicited Increases in Serum Corticosterone Concentration in Rats." In Serotonin: Molecular Biology, Receptors and Functional Effects, 330–38. Basel: Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7259-1_31.

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Numachi, Yohtaro, Sumiko Yoshida, Shigenobu Toda, Hiroo Matsuoka, and Mitsumoto Sato. "Alterations in Corticosterone Receptor mRNA Induced by Methamphetamine in Two Inbred Strains of Rats." In Contemporary Neuropsychiatry, 347–52. Tokyo: Springer Japan, 2001. http://dx.doi.org/10.1007/978-4-431-67897-7_58.

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Conference papers on the topic "Corticosterone"

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Perov, S. Yu, and S. A. Askerova. "THE NEUROENDOCRINE SYSTEM RESPONSE OF 2-5 G COMMUNICATION ELECTROMAGNETIC FIELD ANIMAL EXPOSURE." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-398-402.

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Abstract: Background. The neuroendocrine effect on the hypothalamus-pituitary-adrenal cortex axis is significant example stressor of electromagnetic exposure for biological object. Aim. The neuroendocrine effect investigation of multi-frequency electromagnetic field laboratory animals’ exposure from 2-5 generations cellular base stations Methods. The neuroendocrine status evaluated by corticosterone and adrenocorticotropic hormone (ACTH) concentrations in blood exposed and sham rats. ACTH and corticosterone rat blood assessed by immunoenzyme method. Results. The results of the multi-frequency electromagnetic field laboratory animals’ exposure from 2-5 generations cellular base stations in a chronic experiment showed wave-like changes in the hypothalamic-pituitary-adrenal function. These changes are manifested in an immediate increase in corticosteroids secretion and depression of the corticosteroid response to normal or subnormal levels. After 3 month chronic exposure there was a secondary rise in hormonal secretion.
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Abd-Aziz, N. A. A., D. Durairajanayagam, A. Chatterjee, and R. Chatterjee. "Corticosterone-induced attenuation of epididymal sperm fertility in rats." In 2012 IEEE Colloquium on Humanities, Science and Engineering Research (CHUSER). IEEE, 2012. http://dx.doi.org/10.1109/chuser.2012.6504299.

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Onufriev, Mikhail, Yulia Moiseeva, Natalia Lazareva, Margarita Novikova, and Natalia Gulyaeva. "EFFECT OF CORTICOSTERONE ON NEUROINFLAMMATION INTENSITY IN ISCHEMIC STROKE MODEL." In XIX INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2023. http://dx.doi.org/10.29003/m3323.sudak.ns2023-19/211-212.

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Jones, Nathan, John Razidlo, Zarmeen Zahid, and Cody Wenthur. "Psilocybin-induced anxiolytic effects supported by transient elevation of corticosterone." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.337.128335.

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Nasibah, A., M. H. Rajikin, M. N. K. Nor-Ashikin, and A. S. Nuraliza. "Tocotrienol improves the quality of impaired mouse embryos induced by corticosterone." In 2012 IEEE Colloquium on Humanities, Science and Engineering Research (CHUSER). IEEE, 2012. http://dx.doi.org/10.1109/chuser.2012.6504297.

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"Influence of corticosterone on the late reconsolidation memory in a restricted time window." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.130.

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Mahmud, Iqbal, Bongyong Lee, Ranjan Perera, and Timothy J. Garrett. "Abstract 5273: Multi-omics approaches reveal potential role for corticosterone in prostate cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5273.

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Mahmud, Iqbal, Bongyong Lee, Ranjan Perera, and Timothy J. Garrett. "Abstract 5273: Multi-omics approaches reveal potential role for corticosterone in prostate cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5273.

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XianLi An and XiGeng Zheng. "Post-training corticosterone opposingly modulates fear conditioning of high and low anxiety rats." In 2012 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE, 2012. http://dx.doi.org/10.1109/bhi.2012.6211655.

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Kereya, Аnna, Loubov Zharkova, Аnita Kuptsova, Мichae Bolshakov, Оleg Kutenkov, and Vladislav Rostov. "CORTICOSTERONE LEVEL DYNAMICS IN MICE BLOOD DURING 10 DAY EXPOSURE TO NANOSECOND MICROWAVE PULSES." In XV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m414.sudak.ns2019-15/208.

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Reports on the topic "Corticosterone"

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Thinesen, Pamela. Seasonal trailing behavior and corticosterone levels in male red-sided garter snakes (Thamnophis sirtalis parietalis). Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.5800.

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Tchekalarova, Jana, Tsveta Stoyanova, Rumyana Gesheva, and Milena Atanasova. Agomelatine Treatment Corrects Depressive-like Behaviour Induced by Chronic Constant Light Exposure through Modulation of Circadian Rhythm of Corticosterone Release. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, April 2019. http://dx.doi.org/10.7546/crabs.2019.04.15.

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Rhim, Hye Chang, Joseph Ruiz, Zack Crockett, Wilma Afunugo, and David Robinson. Nonsteroidal anti-inflammatory versus corticosteroid injections in orthopedic conditions. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2023. http://dx.doi.org/10.37766/inplasy2023.8.0003.

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Liang, Huoyan, Heng Song, Hongyi Yan, Xianfei Ding, Tongwen Sun, and Quancheng Kan. Corticosteroid Treating sepsis in Adult Patients: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0122.

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Chang, Min Cheol, and Kyeong Eun Uhm. Comparison of Effectiveness of Intra-articular Hyaluronate and Corticosteroid injections in Adhesive Capsulitis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2024. http://dx.doi.org/10.37766/inplasy2024.3.0072.

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Wang, Hongchen, Yuting Zhu, Hongyu Wei, and Chunke Dong. Ultrasound-Guided Local Corticosteroid Injection for Carpal Tunnel Syndrome: An updated Meta-Analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0027.

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Li, Wenhao, Chunke Dong, Liubo Zhang, Zhencheng Xiong, Yanlei Wang, Hongyu Wei, and Mingsheng Tan. Extracorporeal shock wave therapy versus local corticosteroid injection for the treatment of carpal tunnel syndrome: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2020. http://dx.doi.org/10.37766/inplasy2020.8.0025.

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Zhang, Yong. Efficacy and safety of corticosteroid therapy in patients with cardiac arrest: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0014.

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Review question / Objective: Our goal was to assess the effect of primary treatment outcome (overall survival rate at hospital discharge, rate of sustained ROSC) and secondary outcomes (favorable neurological outcomes at hospital discharge and adverse events including hyperglycemia, insulin infusion, hypernatremia, infection, gastrointestinal bleeding, new or changing antibiotics, paresis, renal failure). Information sources: Two researchers (Zhou FW and Liu C) independently searched the PubMed, Embase, The Cochrane Library, Web of Science and China National Knowledge Internet (CNKI) databases from inception to 11 October, 2022 by using medical subject headings (MeSH), Emtree, and text word with no language limitations.
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Zhou, Fa-Wei, Chang Liu, De-Zhong Li, Yong Zhang, and Fa-Chun Zhou. Efficacy and safety of corticosteroid therapy for in-hospital cardiac arrest: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0026.

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Chang, Yun Chen, Chia-Hsiang Fu, Ta-Jen Lee, and Yi-Chieh Lee. Intranasal corticosteroid for COVID-19 infection related olfactory dysfunction - A Systematic Review and Meta-analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2023. http://dx.doi.org/10.37766/inplasy2023.9.0081.

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