Relevant bibliographies by topics / Cortical Morphometry

Academic literature on the topic 'Cortical Morphometry'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Cortical Morphometry"

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Lai, Kuan-Lin, David M. Niddam, Jong-Ling Fuh, Wei-Ta Chen, Jaw-Ching Wu, and Shuu-Jiun Wang. "Cortical morphological changes in chronic migraine in a Taiwanese cohort: Surface- and voxel-based analyses." Cephalalgia 40, no. 6 (April 16, 2020): 575–85. http://dx.doi.org/10.1177/0333102420920005.

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Background Previous voxel- or surface-based morphometric analysis studies have revealed alterations in cortical structure in patients with chronic migraine, yet with inconsistent results. The discrepancies may be derived partly from the sample heterogeneity. Employing both methods in a clinically homogenous group may provide a clearer view. Methods Structural MRI data from 30 prevention-naïve patients with chronic migraine without medication overuse headache or a history of major depression and 30 healthy controls were analyzed. Vertex-wise (surface-based) or voxel-wise (voxel-based) linear models were applied, after controlling for age and gender, to investigate between-group differences. Averaged cortical thicknesses and volumes from regions showing group differences were correlated with parameters related to clinical profiles. Results Surface-based morphometry showed significantly thinner cortices in the bilateral insular cortex, caudal middle frontal gyrus, precentral gyrus, and parietal lobes in patients with chronic migraine relative to healthy controls. Additionally, the number of migraine days in the month preceding MRI examination was correlated negatively with right insular cortical thickness. Voxel-based morphometry (VBM) did not show any group differences or clinical correlations. Conclusion Patients with chronic migraine without medication overuse headache, major depression, or prior preventive treatment had reduced cortical thickness in regions within the pain-processing network. Compared to voxel-based morphometry, surface-based morphometry analysis may be more sensitive to subtle structural differences between healthy controls and patients with chronic migraine.
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SCHAER, MARIE, ROSITSA PORYAZOVA, SOPHIE SCHWARTZ, CLAUDIO L. BASSETTI, and CHRISTIAN R. BAUMANN. "Cortical morphometry in narcolepsy with cataplexy." Journal of Sleep Research 21, no. 5 (February 6, 2012): 487–94. http://dx.doi.org/10.1111/j.1365-2869.2012.01000.x.

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Murray, Robert D., Judith E. Adams, and Stephen M. Shalet. "A Densitometric and Morphometric Analysis of the Skeleton in Adults with Varying Degrees of Growth Hormone Deficiency." Journal of Clinical Endocrinology & Metabolism 91, no. 2 (February 1, 2006): 432–38. http://dx.doi.org/10.1210/jc.2005-0897.

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Context: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutations suggest that the situation is more complex. Objective: The objective was to define bone areal and volumetric densities and morphometry in hypopituitary adults. Design: The study was a cross-sectional case-controlled study performed between 1999 and 2001. Setting: The study was undertaken at an endocrine tertiary referral center. Patients: Thirty patients with GHD, 24 with GH insufficiency (GHI) [peak GH, 3–7 μg/liter (9–21 mU/liter)], and 30 age- and sex-matched controls were included for study. Main Outcome Measures: DXA and peripheral quantitative computed tomography (pQCT) derived bone density and morphometry were measured. Results: No densitometric or morphometric abnormalities were detected in GHD patients who acquired their deficiency during adult life. GHD adults of childhood-onset (CO-GHD) showed decreased bone mineral density at the lumbar spine and hip on DXA. pQCT of the radius showed that CO-GHD patients have normal trabecular bone mineral density and only a 2% decrease in cortical density. Radial bone area was reduced 14.5%, cortical thickness 20%, and cortical cross-sectional area 23%, culminating in a reduction in cortical bone of 25%. The “apparent” low DXA bone density in CO-GHD adults therefore relates primarily to reduced cortical thickness and smaller bone area. DXA and pQCT data derived from adults with GHI revealed no evidence of densitometric or morphometric abnormalities. Conclusions: 1) Adult-onset GHD patients have normal bone density and size. 2) CO-GHD adults have marginally reduced cortical density but significantly reduced cortical bone as a result of reduced cortical thickness and bone size. 3) GHI has no measurable impact on the skeleton.
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Ino-Kondo, Airi, Hitoshi Hotokezaka, Takanobu Kondo, Keira Arizono, Megumi Hashimoto, Yuka Hotokezaka, Takeshi Kurohama, Yukiko Morita, and Noriaki Yoshida. "Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats." Angle Orthodontist 88, no. 4 (April 2, 2018): 474–82. http://dx.doi.org/10.2319/112017-801.1.

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ABSTRACT Objective: To investigate the influence of lithium chloride (LiCl) on orthodontic tooth movement (OTM), orthodontically induced root resorption (OIRR), and bone morphometry. Materials and Methods: Ten-week-old female Sprague Dawley rats (n = 32) were divided into four groups based on the concentration of LiCl administered daily per kilogram body weight: 0 (control group), 0.32, 0.64, and 1.28 mM/kg body weight. The maxillary left first molars were moved mesially by a 10 cN coil spring for 14 days. Micro-computed tomography, scanning electron microscope, and scanning laser microscope images were taken to measure the amount of OTM, the volume of OIRR, and bone morphometry. Results: OIRR clearly decreased depending on the amount of LiCl administered, although OTM moderately decreased. The tooth inclined mesially and the root apex moved distally in the control and 0.32 mM groups. On the other hand, the tooth inclination angle became smaller and the root apex moved mesially in the 0.64 and 1.28 mM groups. In bone morphometry, the cortical bone mineral content and bone volume increased because of LiCl administration, and the trabecular bone measurements decreased. OIRR negatively correlated to the cortical bone measurements, and the amount of OTM significantly correlated to the cortical bone morphometry. Conclusions: In rats, LiCl reduced OIRR, which induced mesial movement of the tooth root apex. OIRR positively correlated to cortical bone morphometry.
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Shevchenko, A. M., E. L. Pogosbekyan, A. I. Batalov, E. I. Shultz, A. N. Tyurina, L. M. Fadeeva, M. V. Shevchenko, et al. "Automatic Algorithm of Magnetic Resonance Morphometry in the Diagnosis of Focal Cortical Dysplasia." Radiology - Practice, no. 1 (December 23, 2021): 63–76. http://dx.doi.org/10.52560/2713-0118-2022-1-63-76.

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The purpose of the study — to create an original algorithm of MR-morphometry for identifying FCD zones. Based on the use of the ANTs and FSL programs, an algorithm for MR morphometry was developed. It was used to generate maps of the z-index of the blur of the transition of gray and white matter and the thickness of the crust (Junction and thickness maps).An algorithm for automatic detection of focal cortical dysplasia zones has been developed. The MRI morphometry method is a promising technique for additional assessment of pathological changes in focal cortical dysplasia.
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Lehmann, Manja, Sebastian J. Crutch, Gerard R. Ridgway, Sebastien Ourselin, Josephine Barnes, Martin N. Rossor, and Nick C. Fox. "P2-034: Cortical thickness and voxel-based morphometry in posterior cortical atrophy." Alzheimer's & Dementia 5, no. 4S_Part_9 (July 2009): P271—P272. http://dx.doi.org/10.1016/j.jalz.2009.04.343.

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Bashirova, A. R., D. V. Sundukov, A. S. Babkina, M. A. Golubev, and I. N. Telipov. "Morphometry of Cortical Neurons in Acute Clozapine and Ethanol Poisoning." General Reanimatology 16, no. 6 (January 3, 2021): 19–30. http://dx.doi.org/10.15360/1813-9779-2020-6-19-30.

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The aim of the study is to summarize the histology and morphometry of cortical neurons in acute clozapine and ethanol poisoning.Material and methods. Histological examination of the parietal cortical brain samples of 26 patients died during the Day 1 of acute clozapine and ethanol poisoning (23 males and 3 females aged 22-63 years) was performed. The blood ethanol level was 1.4-4.1%o. The level of clozapine in the blood ranged between 0.24 and 5.8 mg%, in the liver between 0.097 and 6.5 mg%, in kidneys between 0.03 and 3.5 mg%. The cortical samples for morphometric examination were placed in 10% neutral paraformaldehyde, the histological sections were done and stained with hematoxylin and eosin, as well as according to Niessl. The morphological analysis was performed using the video light microscopy. The number of damaged neurons (with separate quantification of reversible, intermediate, and irreversible damage) was assessed. The statistical analysis was done using the non-parametric methods.Results. The signs of brain neuronal damage in acute clozapine and ethanol poisoning, as well as forensic chemical tests, might be used for establishing the direct cause of death.
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Bashirova, A. R., D. V. Sundukov, A. S. Babkina, M. A. Golubev, and I. N. Telipov. "Morphometry of Cortical Neurons in Acute Clozapine and Ethanol Poisoning." General Reanimatology 16, no. 6 (January 3, 2021): 19–30. http://dx.doi.org/10.15360/1813-9779-2020-6-19-30.

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The aim of the study is to summarize the histology and morphometry of cortical neurons in acute clozapine and ethanol poisoning.Material and methods. Histological examination of the parietal cortical brain samples of 26 patients died during the Day 1 of acute clozapine and ethanol poisoning (23 males and 3 females aged 22-63 years) was performed. The blood ethanol level was 1.4-4.1%o. The level of clozapine in the blood ranged between 0.24 and 5.8 mg%, in the liver between 0.097 and 6.5 mg%, in kidneys between 0.03 and 3.5 mg%. The cortical samples for morphometric examination were placed in 10% neutral paraformaldehyde, the histological sections were done and stained with hematoxylin and eosin, as well as according to Niessl. The morphological analysis was performed using the video light microscopy. The number of damaged neurons (with separate quantification of reversible, intermediate, and irreversible damage) was assessed. The statistical analysis was done using the non-parametric methods.Results. The signs of brain neuronal damage in acute clozapine and ethanol poisoning, as well as forensic chemical tests, might be used for establishing the direct cause of death.
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Lu, Hanna, Suk Ling Ma, Sandra Sau Man Chan, and Linda Chiu Wa Lam. "The effects of apolipoproteinε4 on aging brain in cognitively normal Chinese elderly: a surface-based morphometry study." International Psychogeriatrics 28, no. 9 (April 21, 2016): 1503–11. http://dx.doi.org/10.1017/s1041610216000624.

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ABSTRACTBackground:Default mode network (DMN) has been reported to be susceptible to APOEε4 genotype. However, the APOEε4-related brain changes in young carriers are different from the ones in elderly carriers. The current study aimed to evaluate the cortical morphometry of DMN subregions in cognitively normal elderly with APOEε4.Method:11 cognitively normal senior APOEε4 carriers and 27 matched healthy controls (HC) participated the neuropsychological tests, genotyping, and magnetic resonance imaging (MRI) scanning. Voxel-based morphometry (VBM) analysis was used to assess the global volumetric changes. Surface-based morphometry (SBM) analysis was performed to measure regional gray matter volume (GMV) and gray matter thickness (GMT).Results:Advancing age was associated with decreased GMV of DMN subregions. Compared to HC, APOEε4 carriers presented cortical atrophy in right cingulate gyrus (R_CG) (GMV: APOE carriers: 8475.23 ± 1940.73 mm3, HC: 9727.34 ± 1311.57 mm3,t= 2.314,p= 0.026, corrected) and left insular (GMT: APOEε4 carriers: 3.83 ± 0.37 mm, HC: 4.05 ± 0.25 mm,t= 2.197,p= 0.033, corrected).Conclusions:Our results highlight the difference between different cortical measures and suggest that the cortical reduction of CG and insular maybe a potential neuroimaging marker for APOE 4εsenior carriers, even in the context of relatively intact cognition.
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Wang, Y., X. Gu, T. F. Chan, A. W. Toga, and P. M. Thompson. "Multivariate Statistics of Tensor-Based Cortical Surface Morphometry." NeuroImage 47 (July 2009): S100. http://dx.doi.org/10.1016/s1053-8119(09)70850-x.

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Dissertations / Theses on the topic "Cortical Morphometry"

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Henry, Maya. "Progressive Aphasia: Patterns of Language Behavior and Regional Cortical Atrophy." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/196034.

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Primary Progressive aphasia (PPA) is a disorder characterized by gradual decline in language functions, with relative sparing of other cognitive abilities. This behavioral profile results from neurodegenerative disease that preferentially affects language cortex. As is the case in aphasia resulting from stroke, any of several critical language processing domains may be affected in PPA, including syntax, semantics, phonology, and orthography. In stroke-induced aphasia, traditional lesion mapping approaches have provided important insight into the localization of cortical regions supporting these domains. Specifically, left perisylvian cortex has been implicated in syntactic and phonological aspects of language, whereas left extrasylvian cortical regions are associated with lexical-semantic and orthographic functions. The goal of the present study was to seek converging evidence for the role of left hemisphere cortical regions in language using a voxel-based imaging technique in individuals with PPA. Fifteen individuals with progressive aphasia and fifteen normal controls were given a comprehensive language battery comprising tasks in the domains of syntax, semantics, phonology, and orthography. A subset of patients and all normal controls underwent high-resolution structural MRI scanning. Voxel-based morphometry (VBM) was used to characterize patterns of regional cortical atrophy in the patients relative to controls and to correlate language tasks with gray matter volumes. Results confirm a key role for left perisylvian cortex in phonological and syntactic processes, and indicate that left temporal regions are critically involved in semantic processes. Findings shed light on the veracity of the "primary systems" hypothesis of written language, which posits that written language impairments arise from core cognitive deficits affecting semantic and phonological systems.
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Mikhael, Shadia S. "Brain cortical variability, software, and clinical implications." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33210.

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It is essential to characterize and quantify naturally occurring morphometric changes in the human brain when investigating the onset or progression of neurodegenerative disorders. The aim of this thesis is to characterize the properties and measure the performance of several popular automated magnetic resonance image analysis tools dedicated to brain morphometry. The thesis begins with an overview of morphometric analysis methods, followed by a literature review focusing on cortical parcellation protocols. Our work identified unanimous protocol weaknesses across all packages in particular issues when addressing cortical variability. The next chapters present a ground truth dataset and a dedicated software to analyse manually parcellated data. The dataset (https://datashare.is.ed.ac.uk/handle/10283/2936) includes 10 healthy middle-aged subjects, whose metrics we used as reference against automated tools. To develop the ground truth dataset, we also present a manual parcellation protocol (https://datashare.is.ed.ac.uk/handle/10283/3148) providing step-by-step instructions for outlining three cortical gyri known to vary with ageing and dementia: the superior frontal gyrus, the cingulate gyrus and the supramarginal gyrus. The software, Masks2Metrics (https://datashare.is.ed.ac.uk/handle/10283/3018), was built in Matlab to calculate cortical thickness, white matter surface area, and grey matter volume from 3D binary masks. Characterizing these metrics allowed further understanding of the assumptions made by software when creating and measuring anatomical parcels. Next, we present results from processing the raw T1-weighted volumes in the latest versions of several automated image analysis tools-FreeSurfer (versions 5.1 and 6.0), BrainGyrusMapping, and BrainSuite (version 13a)- against our ground truth. Tool repeatability for the same system was confirmed as multiple runs yielded identical results. Compared to our ground truth, the closest results were generated by BrainGyrusMapping for volume metrics and by FreeSurfer 6.0 for thickness and surface area metrics. In conclusion, our work sheds light on the significance of clearly detailed parcellation protocols and accurate morphometric tools due to the implications that they both will have. We therefore recommend extra caution when selecting image analysis tools for a study, and the use of independent publicly available ground truth datasets and metrics tools to assist with the selection process.
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Duffield, Tyler Cole. "Cortical Thickness and Voxel-Based Morphometry of Classic Motor Regions of Interest in Autism Spectrum Disorder." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6383.

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Prior research has suggested that any cortical volume (CV) abnormalities in Autism Spectrum Disorder (ASD) need to be further explored by examination of the two determinants of CV, that being cortical thickness (CT) and pial surface area (PSA; Murphy, Beecham, Craig, & Ecker, 2011). The current study suggests that the two determinants of CV should be explored even in the presence of null CV findings, if structure-function analyses are significant (i.e., bi-lateral precentral gyrus and neuropsychological motor test) as demonstrated in the current sample (see Duffield et al., 2013). The only significant anatomic finding was reduced CT in the left frontal motor regions (primarily left precentral gyrus), which also corresponded to the only significant relationship between a motor variable (i.e., grooved pegboard test) and motor region-of-interest (ROI) where ASD had a stronger relationship than typically developing controls (TDC; ASD > TDC). Left hemisphere biased CT group differences has been shown to have the highest classification accuracy (i.e., designation of ASD versus TDC) of morphological parameters (Ecker et al., 2010), yet PSA has been shown to have far greater modulation of CV abnormalities. This is particularly true for subthreshold PSA (Ecker et al., 2013). These prior findings are not only consistent with the current motor ROI findings, but also provide an explanatory framework for the functional neuroanatomy of a generally worse left handed performance (i.e., non-dominant hand) for ASD compared to controls in a generally right handed dominant sample (no significant group differences on handedness). The only significant motor ROI finding was in the left hemisphere (i.e., ipsilateral to worse left handed performance), but subthreshold PSA findings in the right precentral were found and likely provide explanatory power of motor performances in the aggregate, despite a lack of significant statistical differences in a specific motor ROI individually.
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Ueno, Tsukasa. "Sex-specific regional grey matter volume correlates of daily activities." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263563.

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Magrì, Salvatore. "Characterization of cerebral cortex folding in humans through MRI: quality control and dementia prediction." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21245/.

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Magnetic resonance imaging (MRI) is a valuable tool for non-invasively investigating human brain anatomy and functions. The features extracted from MRI data can be used as biomarkers for neurodegenerative diseases, like Dementia. To deeply understand the mechanisms driving the brain changes it is crucial to extract reliable measures from the brain MRI scans and to increase the statistical power by harmonizing different datasets, such as in the ENIGMA studies. Here we applied the ENIGMA-SULCI pipeline to estimate the reliability of the sulcal descriptors extracted across the whole brain and to investigate their correlation with CDR (Clinical Dementia Rating) in the open access dataset OASIS. The OASIS dataset includes T1-weighted acquired from 416 right-handed subjects, for 227 of whose we know CDR. The measurement reliability has been estimated through technical replicates of a subgroup of patients MRI scans. The correlation of each sulcal shape descriptor with the degree of Dementia has been tested through linear regressions between each feature and the CDR series. We have trained linear (regression) and nonlinear (Neural Networks) Machine Learning models in order to classify the subjects in two classes (Dementia and healthy subjects). We got models able to correctly classify more than the 70% of the dataset, starting from sulcal measures.
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Wirth, Anna Maria [Verfasser], and Mark W. [Akademischer Betreuer] Greenlee. "Structural magnetic resonance imaging in amyotrophic lateral sclerosis: cortical morphometry, diffusion properties and lesion detection as potential biomarkers for the state and progression of amyotrophic lateral sclerosis / Anna Maria Wirth ; Betreuer: Mark W. Greenlee." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1188026658/34.

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Winkler, Anderson M. "Widening the applicability of permutation inference." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:ce166876-0aa3-449e-8496-f28bf189960c.

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This thesis is divided into three main parts. In the first, we discuss that, although permutation tests can provide exact control of false positives under the reasonable assumption of exchangeability, there are common examples in which global exchangeability does not hold, such as in experiments with repeated measurements or tests in which subjects are related to each other. To allow permutation inference in such cases, we propose an extension of the well known concept of exchangeability blocks, allowing these to be nested in a hierarchical, multi-level definition. This definition allows permutations that retain the original joint distribution unaltered, thus preserving exchangeability. The null hypothesis is tested using only a subset of all otherwise possible permutations. We do not need to explicitly model the degree of dependence between observations; rather the use of such permutation scheme leaves any dependence intact. The strategy is compatible with heteroscedasticity and can be used with permutations, sign flippings, or both combined. In the second part, we exploit properties of test statistics to obtain accelerations irrespective of generic software or hardware improvements. We compare six different approaches using synthetic and real data, assessing the methods in terms of their error rates, power, agreement with a reference result, and the risk of taking a different decision regarding the rejection of the null hypotheses (known as the resampling risk). In the third part, we investigate and compare the different methods for assessment of cortical volume and area from magnetic resonance images using surface-based methods. Using data from young adults born with very low birth weight and coetaneous controls, we show that instead of volume, the permutation-based non-parametric combination (NPC) of thickness and area is a more sensitive option for studying joint effects on these two quantities, giving equal weight to variation in both, and allowing a better characterisation of biological processes that can affect brain morphology.
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Delgado, Thiago Ferreira Gonçalves [UNESP]. "Produção leiteira em cabras da raça Saanen: influência dos hormônios cortisol e IGF-I." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/96600.

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Made available in DSpace on 2014-06-11T19:28:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-12-08Bitstream added on 2014-06-13T20:58:01Z : No. of bitstreams: 1 delgado_tfg_me_jabo.pdf: 1053821 bytes, checksum: 151e3e8ed68856f56009d9bdde539d85 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
A seleção de animais mais precoces e produtivos, e a melhoria da qualidade do leite são os principais objetivos dos caprinocultores. Com o objetivo de avaliar a interação de dois importantes hormônios, o Cortisol (CORT) e o Fator de Crescimento Análogo à Insulina -1 (IGF-1) na lactação, e suas possíveis influências no desenvolvimento da glândula mamária, produção e qualidade do leite, 38 cabritas (na 1ª fase do experimento) e 24 cabras (na 2ª e 3ª fase do experimento) Saanen divididas em quatro grupos (G1- tratadas com GH e desafiadas com ACTH; G2 – tratadas com GH e desafiadas com placebo; G3 – tratadas com placebo e desafiadas com ACTH; e G4 – tratadas com placebo e desafiadas com placebo). Ao longo de todo experimento foram realizadas coletas de sangue pontuais e durante os desafios, medidas morfométricas internas e externas de úbere e tetos foram realizadas e análises da composição do leite. Não houve diferença no desenvolvimento de úbere e tetos entre animais tratados e não tratados com GH, porém houve maior produção de leite pelos animais tratados, confirmando a eficiência do hormônio em promover maior persistência de lactação. Também houve uma resposta antagônica do IGF-1 ao CORT, durante o desafio das cabras na 3ª fase do experimento, resultado que pode indicar que animais adultos tratados com GH são menos suscetíveis ao estresse que os animais não tratados. O desafio com ACTH e o tratamento com GH não alteraram a composição do leite e a contagem de células somáticas.
The selection of early animals and more productives, and improving the quality of milk are the main goals of goat breeders. With the objective of evaluating the interaction of two important hormones, cortisol (CORT) and the Insulin-Like Growth Factor -1 (IGF-1) in milk, and their possible influences on the development of the mammary gland, yield and quality of milk, 38 kid goats (the 1st. phase of the trial) and 24 goats (in the 2nd and 3rd phase of the trial) Saanen divided into four groups (G1- treated with GH (growth hormone) and challenged with ACTH (adrenocorticotropic hormone), G2 - treated with GH and challenged with placebo; G3 - treated with placebo and challenged with ACTH, and G4 - treated with placebo and challenged with placebo). Throughout experiment samples of blood were collected, internal and external morphometric measures of udder and teats reviews were performed and were performed composition of milk. There were not differences in the development of udder and teats of animals treated and not treated with GH, but treated animals showing higher production than non treated goats, confirming the effectiveness of treatment with GH in promoting increase on persistence of lactation. There was also a response of IGF- 1 antagonist to CORT, the challenge of goats during the 3rd phase of the experiment, result that may indicate that adults treated with GH are less susceptible to stress that the animals not treated. The challenge with ACTH and treatment with GH did not alter the composition of milk and somatic cell count.
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Delgado, Thiago Ferreira Gonçalves. "Produção leiteira em cabras da raça Saanen : influência dos hormônios cortisol e IGF-I /." Jaboticabal : [s.n.], 2008. http://hdl.handle.net/11449/96600.

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Orientador: João Alberto Negrão
Banca: Izabelle Auxiliadora Molina de Almeida Teixeira
Banca: Marco Aurélio de Felício Porcionato
Resumo: A seleção de animais mais precoces e produtivos, e a melhoria da qualidade do leite são os principais objetivos dos caprinocultores. Com o objetivo de avaliar a interação de dois importantes hormônios, o Cortisol (CORT) e o Fator de Crescimento Análogo à Insulina -1 (IGF-1) na lactação, e suas possíveis influências no desenvolvimento da glândula mamária, produção e qualidade do leite, 38 cabritas (na 1ª fase do experimento) e 24 cabras (na 2ª e 3ª fase do experimento) Saanen divididas em quatro grupos (G1- tratadas com GH e desafiadas com ACTH; G2 - tratadas com GH e desafiadas com placebo; G3 - tratadas com placebo e desafiadas com ACTH; e G4 - tratadas com placebo e desafiadas com placebo). Ao longo de todo experimento foram realizadas coletas de sangue pontuais e durante os desafios, medidas morfométricas internas e externas de úbere e tetos foram realizadas e análises da composição do leite. Não houve diferença no desenvolvimento de úbere e tetos entre animais tratados e não tratados com GH, porém houve maior produção de leite pelos animais tratados, confirmando a eficiência do hormônio em promover maior persistência de lactação. Também houve uma resposta antagônica do IGF-1 ao CORT, durante o desafio das cabras na 3ª fase do experimento, resultado que pode indicar que animais adultos tratados com GH são menos suscetíveis ao estresse que os animais não tratados. O desafio com ACTH e o tratamento com GH não alteraram a composição do leite e a contagem de células somáticas.
Abstract: The selection of early animals and more productives, and improving the quality of milk are the main goals of goat breeders. With the objective of evaluating the interaction of two important hormones, cortisol (CORT) and the Insulin-Like Growth Factor -1 (IGF-1) in milk, and their possible influences on the development of the mammary gland, yield and quality of milk, 38 kid goats (the 1st. phase of the trial) and 24 goats (in the 2nd and 3rd phase of the trial) Saanen divided into four groups (G1- treated with GH (growth hormone) and challenged with ACTH (adrenocorticotropic hormone), G2 - treated with GH and challenged with placebo; G3 - treated with placebo and challenged with ACTH, and G4 - treated with placebo and challenged with placebo). Throughout experiment samples of blood were collected, internal and external morphometric measures of udder and teats reviews were performed and were performed composition of milk. There were not differences in the development of udder and teats of animals treated and not treated with GH, but treated animals showing higher production than non treated goats, confirming the effectiveness of treatment with GH in promoting increase on persistence of lactation. There was also a response of IGF- 1 antagonist to CORT, the challenge of goats during the 3rd phase of the experiment, result that may indicate that adults treated with GH are less susceptible to stress that the animals not treated. The challenge with ACTH and treatment with GH did not alter the composition of milk and somatic cell count.
Mestre
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Semaan, Marie. "Characterization of the mechanical behavior of growing bone based on new imaging methods." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0129/document.

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De nos jours, l’étude biomécanique des structures osseuses représentent un enjeu pour différents domaines: accidentologie, prise en charge des pathologies osseuses, confort des personnes âgées, conception de prothèses innovantes, etc. Le but de cette thèse est de fournir des valeurs de référence représentatives de la qualité de l'os enfant en caractérisant des propriétés mécaniques et morphométriques du tissu osseux en croissance à différentes échelles. Les propriétés mécaniques ont été mesurées à 2 échelles différentes – mésoscopique et microscopique – selon 2 modalités expérimentales – spectroscopie à résonance ultrasonore et microindentation. Un autre volet de cette thèse concerne le développement d’une procédure d’analyse morphométrique adaptée au tissu osseux pour le traitement d’images obtenues par micro-tomographie (RX). Mieux connaître le tissu osseux juvénile est indispensable pour développer des modèles dédiés et ainsi mieux comprendre les mécanismes pathologiques caractéristiques de l'os en croissance (fracture en bois vert) pour améliorer le diagnostic et adapter les choix thérapeutiques pour les jeunes patients
Nowadays, the biomechanical study of bone structures is a challenge for different fields: accidentology, management of bone pathologies, comfort for the elderly, design of innovative prostheses, etc. The aim of this thesis is to provide reference values representative of the quality of child bone by characterizing the mechanical and morphometric properties of growing bone tissue at different scales. Mechanical properties were measured at 2 different scales - mesoscopic and microscopic - in 2 experimental modalities – resonant ultrasound spectroscopy and microindentation. Another part of this thesis concerns the development of a morphometric analysis procedure adapted to bone tissue for the treatment of images obtained by micro-tomography (RX). A better knowledge of juvenile bone tissue is essential to develop dedicated models and thus better understand the pathological mechanisms characteristic of growing bone (greenstick fracture) to improve diagnosis and adapt therapeutic choices for young patients
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Books on the topic "Cortical Morphometry"

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Boedhoe, Premika S. W., and Odile A. van den Heuvel. The Structure of the OCD Brain. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0023.

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This chapter summarizes the most consistent findings of structural neuroimaging studies of obsessive-compulsive disorder (OCD), and discusses their relationship within the implicated brain networks. The techniques used in these studies are diverse, and include manual tracing of specific regions of interest, whole-brain voxel-based morphometry (VBM) for both gray matter and white matter volume comparisons, FreeSurfer to investigate differences in cortical thickness and subcortical volumes, and other methods such as covariance analyses. Findings on white matter integrity with tract-based spatial statistics (TBSS) and in diffusion tensor imaging (DTI) studies are discussed as well.The literature shows that the pathophysiology of OCD cannot be explained by alterations in function and structure of the classical cortico-striato-thalamo-cortical (CSTC) regions exclusively, but that fronto-limbic and fronto-parietal connections are important as well, and the role of the cerebellum needs more attention in future research.
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Book chapters on the topic "Cortical Morphometry"

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Zhang, Min, Dongsheng An, Na Lei, Jianfeng Wu, Tong Zhao, Xiaoyin Xu, Yalin Wang, and Xianfeng Gu. "Cortical Morphometry Analysis Based on Worst Transportation Theory." In Lecture Notes in Computer Science, 163–76. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78191-0_13.

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Fan, Yonghui, Gang Wang, Natasha Lepore, and Yalin Wang. "A Tetrahedron-Based Heat Flux Signature for Cortical Thickness Morphometry Analysis." In Medical Image Computing and Computer Assisted Intervention – MICCAI 2018, 420–28. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-00931-1_48.

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Tosun, Duygu, Simon Duchesne, Yan Rolland, Arthur W. Toga, Marc Vérin, and Christian Barillot. "3-D Analysis of Cortical Morphometry in Differential Diagnosis of Parkinson’s Plus Syndromes: Mapping Frontal Lobe Cortical Atrophy in Progressive Supranuclear Palsy Patients." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007, 891–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-75759-7_108.

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Awate, Suyash P., Lawrence Win, Paul Yushkevich, Robert T. Schultz, and James C. Gee. "3D Cerebral Cortical Morphometry in Autism: Increased Folding in Children and Adolescents in Frontal, Parietal, and Temporal Lobes." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008, 559–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-85988-8_67.

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Evans, A. C. "Cortical Surface Morphometry." In Brain Mapping, 157–66. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-397025-1.00210-4.

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Conference papers on the topic "Cortical Morphometry"

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Van Horn, John Darrell, Shantanu H. Joshi, and Ian Bowman. "Graphical data mining of human cortical surface morphometry." In 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI 2013). IEEE, 2013. http://dx.doi.org/10.1109/isbi.2013.6556445.

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Qu, Zongshuai, Nan Li, and Gang Wang. "A Univariate Morphometry Index for AD-induced Abnormal Cortical Surface Pattern Similarity Measurement." In 2022 4th International Conference on Industrial Artificial Intelligence (IAI). IEEE, 2022. http://dx.doi.org/10.1109/iai55780.2022.9976557.

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Slesareva, E. V., R. V. Ureneva, S. M. Slesarev, and O. V. Lyapeykova. "The pathomorphology of the renal cortex depending of arterial hypertension duration course." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-180-183.

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The kidneys autopsy material of persons with arterial hypertension in different duration was examined. Morphometry of the renal corpuscle area and cortical and juxtamedullary nephrons vascular glomeruli was performed. There were 4 groups - a control group (with a normal blood pressure level), and groups with arterial hypertension - the initial stage (group 2), arterial hypertension for 5-10 years (group 3), long-term arterial hypertension - more than 10 years (group 4). It was found that cortical nephrons are distinguished by earlier and more pronounced hyperplasia of the vascular glomerulus, they are more rapidly exposed to sclerosis, which appears in the 5-10th year of the course of the disease. The hyperplasia of the vascular glomerulus components is progressively increasing in juxtaglomerular nephrons, they are less susceptible to sclerosis processes. Key words: arterial hypertension, juxtaglomerular apparatus, juxtamedullary nephrons, vascular glomerulus.
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Shishegar, Rosita, Sudeshna Rajapakse, and Nellie Georgiou-Karistianis. "Altered Cortical Morphometry in Pre-manifest Huntington’s Disease: Cross-sectional Data from the IMAGE-HD Study." In 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2019. http://dx.doi.org/10.1109/embc.2019.8857240.

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Souza, Thierry Kaue Alves Silva, Nara Maria Borges Alves, Fabiana Moraes, Felipe de Paula, Luciana Yasuda Suemitsu, Paula Azevedo, Luiza Piovesana, et al. "Cortical and subcortical atrophy in individuals with Huntington's disease and Huntington-like disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.551.

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Background: Huntington-like (HL) syndrome represents a group of diseases clinically similar to Huntington disease (HD) with different genetic etiology. Here, we aimed to compare clinical and neuroimaging features between HL and HD. Methods: We assessed 12 patients with HL (6 men; 53.66±13.02 years old) and 12 with HD (genetically confirmed, 6 men; 52.58±11.64 years old). All patients were followed at UNICAMP and were matched to sex, age, age at onset and duration of disease. They underwent 3T MRI scans, detailed neurological examination, the unified Huntington’s disease rating scale (UHDRS), the Montreal cognitive assessment (MOCA), Beck depression inventory (BDI), and the scale for the evaluation of rating ataxia (SARA). We APPLIED voxel-based morphometry technique (SPM12/CAT12/MATLAB software) to assess differences in the gray and white matters between groups and matched controls. Results: Groups were clinically similar, but the VBM study revealed widespread cortical (bilateral) and subcortical atrophy in HD (bilateral globi pallidi, amygdala, hippocampi, caudate and putamen), with a more restricted cortical (left temporal lobe) subcortical atrophy in HL (bilateral thalami, putamen and left hippocampus). Cortical atrophy in HL concentrated in the bilateral putamen. The left hippocampus were atrophic in both groups. Conclusion: Despite similar clinical presentation, patients with HL and HD have distinctive patterns of atrophy subcortical structures, mainly in the thalami. These results may raise insights into the underlying disease mechanisms in HL and HD and could be useful as biomarkers of disease progression in future therapy trials.
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Ciarlini, Bruna, Flávia E. Silva, Álissa Moura, Emmanuelle Sobreira, Roberto Paiva, Norberto Frota, and Fernanda Carvalho. "ACCUMBENS AREA MAY PLAY A ROLE IN FACIAL RECOGNITION OF EMOTIONS IN A LOW-EDUCATED POPULATION WITH MILD ALZHEIMER’S DISEASE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda064.

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Background: There is no consensus on how recognition of universal facial emotions can be affected in low-educated individuals with Alzheimer’s Disease (AD). Objective: To assess the performance of Facial Recognition of Emotions Test (FERT) and to correlate with patterns of cortical atrophy measured through Voxel-Based Morphometry (VBM) in low-educated individuals with mild AD dementia compared to cognitively healthy people. Methods: Retrospective cohort of 24 adult volunteers with 4 years of schooling or less were included. Among them, 13 participants had a diagnosis of mild AD. Data obtained by VBM and FERT result were correlated. Results: AD group had a worse performance in the total FERT score (p <0.001). There was a statistically significant difference in the recognition of surprise, disgust and neutrality (p <0.001). A more intense and consistent correlation was observed between the volume of the Accumbens Area (AA) and FERT performance in the total group (r=0.817 and p <0.05). This correlation remained significant for emotion “disgust” only in the AD group (r=0.769 and p <0.05). Conclusion: We found a significant difference in the recognition of surprise, disgust and neutral emotions between groups. The brain region that was most associated with these emotions was the AA, with greater consistency in the difficulty in recognizing the emotion of disgust, in the AD.
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Ceyhan, E., M. Hosakere, T. Nishino, J. Alexopoulos, R. D. Todd, K. N. Botteron, M. I. Miller, and J. T. Ratnanather. "Statistical Analysis of Morphometric Measures Based on Labeled Cortical Distance Maps." In 2007 5th International Symposium on Image and Signal Processing and Analysis. IEEE, 2007. http://dx.doi.org/10.1109/ispa.2007.4383656.

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Tsai, Andrew G., Timothy Ashworth, and Ozan Akkus. "Strength of Materials Based Prediction of Critical Stresses at the Proximal Femur: Validation by Finite Element Analysis." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14208.

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A small but significant fraction of screw placement in the proximal femur for hip fractures results in iatrogenic fractures associated with the screw hole [1]. There is evidence that the failure occurs under fatigue, and it is likely that those individuals experiencing failure have greater stresses in the proximal femur as dictated by key morphometric variables, such as cortical thickness and bone size. Finite element analysis (FEA) could greatly facilitate fracture risk assessment in the presurgical phase by predicting the local stresses, however, executing FEM in a patient customized fashion would be costly, time consuming, and technically difficult for surgeons to perform.
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