Log in

Relevant bibliographies by topics / Coronary heart disease / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Coronary heart disease.

Dissertations / Theses on the topic 'Coronary heart disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Coronary heart disease.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Brouilette, Scott Wayne. "Telomeres and coronary heart disease." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29899.

Full text

Abstract:

Using mean telomere length as a marker of biological age, I show that: 1. Subjects with premature myocardial infarction (MI) have significantly shorter telomeres than age-sex matched, healthy, controls. The mean telomere length in MI subjects was similar to controls almost 11 years older. 2. Healthy young adult children of families with a strong history of premature MI have shorter telomeres than age matched children of families without such a history. 3. Shorter telomere lengths are associated with increase risk of subsequent CHD events in a prospective study. This analysis was carried out on samples collected in the West of Scotland Coronary Prevention Study (WOSCOPS). This randomised blinded trial was designated to examine the benefits of statin treatment on preventing CHD and showed a 30% reduction of events in those treated with pravastatin. Interestingly, my analysis showed that this benefit of statin is only seen in those subjects at higher risk of CHD based on their telomere length.;As the final part of the thesis I carried out a quantitative linkage trait (QTL) analysis in sib-pairs in an attempt to identify genetic loci regulating telomere length. I report the mapping of a major QTL on chromosome 12 that determines almost 50% of the inter-individual variation in mean telomere length.;These findings support a novel "telomere" hypothesis of CHD. They indicate that telomere biology is intimately linked to the genetic aetiology and pathogenesis of CHD. Specifically, the findings suggest that (i) those individuals born with shorter telomeres may be at increased risk of CHD (ii) rather than individual genes, a more global structural property of the genetic material may explain the familial basis of CHD (iii) variation in telomere length may explain, in part, the variable age of onset of CHD. The findings provide several new avenues for future research.

APA, Harvard, Vancouver, ISO, and other styles

2

Lee, Chi-hang. "Microvascular obstruction following percutaneous coronary intervention for coronary artery disease." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43278723.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Heiser, Claire Anne. "Personality predictors of coronary heart disease." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/50027.

Full text

Abstract:

Fifty percent of the diagnosed cases of coronary heart disease in the United States are of unknown etiology. This study proposed that five personality traits— achievement, dominance, aggression, succorance and Critical Parent—differentiate individuals with coronary heart disease manifestations. The ultimate goal of this research was to formulate a predictive profile of at-risk individuals of developing coronary heart disease. Cardiac rehabilitation units' participants from across the United States were recruited as subjects. Randomly selected cardiac rehabilitation units were sent an initial letter inquiring whether their staff would be willing to participate in the study by administering the instruments to their participants. Eight units from each of the 50 states were contacted. A total of fourteen units agreed to participate. One hundred sixty-nine subjects completed the Demographic Data Questionnaire and the Adjective Check List. Five scale scores, representing the five personality differentials, were analyzed. Comparison of the male subject population (n=135) and the male normative population (n=198) revealed no significant differences in terms of the five traits. Comparison of diagnostic subgroups of the subject population also revealed no significant differences. It was concluded that the subject population did not differ significantly from the normative population in terms of the five traits assess by the instrument used. The goal of a predictive profile was not realized due to this lack of findings.
Master of Science
incomplete_metadata

APA, Harvard, Vancouver, ISO, and other styles

4

Lee, Chi-hang, and 李志恆. "Microvascular obstruction following percutaneous coronary interventionfor coronary artery disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43278723.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Danesh, John. "Chronic infection and coronary heart disease." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kounali, Daphne. "Early growth and coronary heart disease." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436926.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Zapanta, Laurence (Laurence F. ). "Heart rate variability in mice with coronary heart disease." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34118.

Full text

Abstract:

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
Includes bibliographical references (leaves 69-71).
Heart rate variability (HRV), the beat-to-beat fluctuation of the heart rate, is a non-invasive test that measures the autonomic regulation of the heart. Assessment of HRV has been shown to predict the risk of mortality in patients after an acute myocardial infarction. Recently, the Krieger lab at MIT developed genetically engineered double knockout (dKO) mice that develop coronary artery disease accompanied by spontaneous myocardial infarctions and die at a very young age. This thesis investigated whether HRV could function as a prognostic indicator in the dKO mouse. A novel method for estimating physiological state of the mouse from the electrocardiogram using an innovative activity index was developed in order to compare HRV variables at different times while controlling for physiologic state. Traditional time and frequency domain variables were used to assess the prognostic power of HRV. Results have shown that none of the HRV variables were helpful in predicting mortality in the dKO mice. Mean heart rate showed some prognostic power, but it was not consistent in all the dKO mice. Finally, the activity index developed in this thesis provided a reliable metric for activity in mice as validated by a camera with motion detection.
by Laurence Zapanta.
S.M.

APA, Harvard, Vancouver, ISO, and other styles

8

Rose, Edward Leslie. "Coronary heart disease in patients with peripheral vascular disease." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305544.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Bagés, Nuri. "Psychosocial risk factors and coronary heart disease." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2000. http://arno.unimaas.nl/show.cgi?fid=6899.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Chandola, Tarani. "Social inequality in coronary heart disease outcomes." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Freitag, Daniel Franz. "Inflammatory pathways and coronary heart disease risk." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648461.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Гордіна, Марина Андріївна, Марина Андреевна Гордина, and Maryna Andriivna Hordina. "Vitamin D deficiency and coronary heart disease." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/33551.

Full text

Abstract:

Coronary heart disease (CHD) is the result of the accumulation of atheromatous plaques within the walls of the arteries that supply the myocardium with oxygen and nutrients. The WHO estimated that in 2002, 12.6% of deaths worldwide were from CHD. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/33551

APA, Harvard, Vancouver, ISO, and other styles

13

Du, Ying. "Ischemic and pharmacological preconditioning of rat myocardium : effects on ischemia-reperfusion injury /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20DU.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ho, Lai-yi Ada. "Does social support influence coronary heart disease prognosis? : a meta-analysis /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/b39724116.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Dorn, Karen LaVonne Toft. "Circulatory, hormonal, and metabolic effects of arbutamine compared to exercise in persons with known or suspected coronary artery disease /." This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06062008-164634/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Zdravkovic, Slobodan. "Coronary heart disease in Swedish twins : quantitative genetic studies /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-771-5/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Tinati, Mohammad Ali. "Time-frequency and time-scale analysis of phonocardiograms with coronary artery disease before and after angioplasty /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09pht587.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Bose, Jolly. "Percutaneous transluminal coronary angioplasty (PTCA) in the treatment of coronary artery disease in Hong Kong : procedural success, complications and long-term follow-up /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2084282X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Guibert, Remy L. "Death certificate coding variation and coronary heart disease." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66229.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Huff, Natasha Clare. "Coronary heart disease and the socio-economic environment." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339634.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Bolton, Jennifer Lynn. "Candidate genotypes in prediction of coronary heart disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/15877.

Full text

Abstract:

Introduction There has been much discussion on personalised medicine; however use of genotype in risk prediction for coronary heart disease (CHD) has not resulted in appreciable improvements over non-genetic risk factors. The primary aim was to determine whether candidate single nucleotide polymorphisms (SNPs) identified from genome-wide association studies improved prediction of CHD over conventional risk factors (CRF). The secondary aim was to determine whether the use of apolipoproteins or lipoprotein(a) improved risk prediction of CHD. Methods Analyses used the Edinburgh Heart Disease Prevention Study (EHDPS), with 1592 men aged 30-59 and follow-up after 20 years; and the Edinburgh Artery Study (EAS), with 1592 men and women aged 54-75 and 15 years of follow-up. Candidate SNPs were identified by systematic literature reviews. CHD status was evaluated as severe (myocardial infarction or coronary revascularisation), and any (severe CHD, angina or non-specified ischaemic heart disease). Cox proportional hazards models were used to evaluate addition of candidate SNPs or lipids to models containing CRF. Results A group of genome-wide significant SNPs resulted in a non-significant improvement in C-index for severe CHD (0.038, p=0.082), and a significant improvement in C-index for any CHD (0.042, p=0.016); the associated net reclassification improvements (NRI) were 20.5% and 18.7%, respectively. Regression trees identified SNPs that were predictive of the remaining variance after adjusting for CRF; this resulted in a significant improvement in C-index for any CHD (0.031, p=0.008). The NRI were 11.0% and 9.6% for severe and any CHD, respectively. When compared with HDL cholesterol/total cholesterol, apolipoprotein AI/total cholesterol yielded a NRI of 3.3% for severe CHD. Lipoprotein(a) improved prediction of severe CHD, with a non-significant improvement in C-index (0.020, p=0.087), and NRI of 11.8%. Conclusion The results of this study indicate that a well selected group of candidate SNPs can improve risk prediction for CHD over-and-above CRF. The inclusion of lipoprotein(a), along with CRF, appeared to improve prediction of severe CHD, but not any CHD.

APA, Harvard, Vancouver, ISO, and other styles

22

Wilson, Andrew. "Ethnicity, coronary heart disease risk and platelet aggregation." Thesis, The University of Sydney, 1996. https://hdl.handle.net/2123/27600.

Full text

Abstract:

Objectives: Part A. To analyse existing risk-factor studies in the population of Sydney for differences in established risk factors, particularly smoking, blood pressure and blood lipids, between Southern-European-born migrants and Australian-born subjects. Part B. To examine a sample of Southern-European and Australia-born men without current CHD, of similar socio-economic background to: i. Compare factors relating to haemostasis and coagulation which have been reported as predictive of CHD risk, especially platelet aggregability, fibrinogen and Factor VIIc levels. ii. Compare other measures of haemostasis and coagulation which have been reported as varying among ethnic groups. iii. Examine the determinants of platelet aggregability, especially the nutrient content of their usual diet. iv. Examine the relations among established risk factor for CHD and measures of platelet aggregability.

APA, Harvard, Vancouver, ISO, and other styles

23

Kunutsor, Setor Kwadzo. "Markers of liver dysfunction and risk of coronary heart disease." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708216.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Sitt, Wing-hung Edward. "Is the validity of non-invasive computerized tomography coronary angiography equivalent to invasive coronary angiography for the evaluation of coronary artery disease." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38479606.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Leong, Yuk-yan Pauline, and 梁玉恩. "The effectiveness of exercise-based cardiac rehabilitation program for secondary prevention of coronary heart disease : a systematic review." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193828.

Full text

Abstract:

Objective: To examine the effect of exercise-based cardiac rehabilitation program for secondary prevention of coronary heart disease on cardiac-related mortality, recurrent cardiovascular event and quality of life. Methods: All studies published between 1990 and 2013 in PubMed, and from 1980 to 2013 in EMBASE, which evaluated the effectiveness of exercise-based cardiac rehabilitation program for coronary heart disease. Using the specific keywords “Cardiac rehabilitation”, “Coronary heart disease” OR “Ischemic heart disease” [MeSH], “Exercise” OR “Physical activities” AND “Quality of life” OR “Mortality” AND Cardiovascular events” were searched. A total of 7randomized controlled trials out of 5,051articles from PubMed and 117 articles from EMBASE were included in this systematic review. The primary outcome measures used in the included seven studies were HRQOL, restenosis, cardiac event, cardiac related mortality. Similar demographic and clinical characteristics of the subjects between the intervention and the control groups were recorded. The studies were from five countries. The average age of the subjects in the seven studies was 61years, the average half of them have history of myocardial infarction. Though there were discrepancies among the results generated in the included studies, the potential benefits of exercise-based cardiac rehabilitation could be seen. Results: Compared with the non-exercise-based cardiac rehabilitation, patients allocated to the exercise-based cardiac rehabilitation program had greater improvement in HRQOL and reduction of cardiac events. The result of reducing restenosis was inconsistent. The cardiac related mortality is not significant difference between exercise-based and non-exercise-based cardiac rehabilitation.
published_or_final_version
Public Health
Master
Master of Public Health

APA, Harvard, Vancouver, ISO, and other styles

26

Lee, Hang-ling Justine. "An exploratory study of the psycho-social stress of coronary heart disease patients /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2233094X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Thompson, Mary. "Coronary effects of endothelins." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296580.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Liu, Longjian, and 劉隆健. "Population based studies of fibrinogen in relation to other coronary heart disease risk factors, coronary heart disease and diabetesmellitus in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237447.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Sitt, Wing-hung Edward, and 薛穎雄. "Is the validity of non-invasive computerized tomography coronary angiography equivalent to invasive coronary angiography for theevaluation of coronary artery disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39724578.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Liu, Longjian. "Population based studies of fibrinogen in relation to other coronary heart disease risk factors, coronary heart disease and diabetes mellitus in Hong Kong /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19926583.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Hogg, Marilynne Audrey. "Women living with coronary heart disease, barriers to care." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0024/MQ51753.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Järemo, Petter. "Platelets and the inflammatory response in coronary heart disease /." Linköping, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med816s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Eriksson-Berg, Margita. "Hemostasis in middle-aged women with coronary heart disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-978-1/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Al-Khalili, Faris. "Coronary heart disease in women : diagnostic and prognostic markers /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4092-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

McKeigue, Paul Matthew. "Epidemiology of coronary heart disease in Asians in Britain." Thesis, University College London (University of London), 1990. http://discovery.ucl.ac.uk/1350028/.

Full text

Abstract:

In countries where people of South Asian origin have settled, unexpectedly high coronary heart disease rates have been recorded in South Asian men and women compared with other ethnic groups. In England high CHD mortality is shared by Gujarati Hindus, Punjabi Sikhs and Muslims from Pakistan and Bangladesh. The high CHD rates in these populations are unexplained by levels of smoking, blood pressure, plasma cholesterol or dietary fat intake. To test whether disturbances of haemostatic activity, lipoprotein metabolism or carbohydrate metabolism might underlie the high CHD mortality in South Asians, a population study in east London was undertaken. The results confirmed that the high CHD rates in South Asians compared with the native British population cannot be explained by differences in the distributions of blood pressure or plasma cholesterol. The hypothesis of a disturbance of haemostatic activity was not supported. A pattern of low plasma HDL cholesterol and high triglyceride levels, high serum insulin levels after a glucose load and high prevalence of non-insulin-dependent diabetes was identified in CD Bangladeshis. On the basis of these findings and a review of other recent work it is suggested that: (i) insulin resistance underlies these disturbances of lipoprotein and carbohydrate metabolism in Bangladeshis; (ii) this tendency to insulin resistance is a general pattern in South Asian populations overseas; and (iii) it is a possible underlying mechanism for the high rates of both CHD and diabetes in these populations. The planning of a large study to test this is described. Preliminary results confirm that a syndrome of metabolic disturbances related to insulin resistance, first identified in Bangladeshis, is present also in Gujaratis and Punjabis. This is associated with a striking tendency to central obesity in South Asians. These findings point to the aetiological role of insulin resistance in CHD and suggest possible strategies for prevention in South Asian communities.

APA, Harvard, Vancouver, ISO, and other styles

36

capewell, simon. "defining and addressing the burden of coronary heart disease." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493051.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Doshi, Sagar Navinchandra. "Homocysteine, folate and endothelial function in coronary heart disease." Thesis, Cardiff University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444121.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Nicholson, Amanda Claire. "Psychological distress as a predictor of coronary heart disease." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406151.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Gorman, Donal Neilson. "Triglycerides, the APOA5-APOC3 locus and coronary heart disease." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707967.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Wu, Kelvin Kwan Hoe. "Gene-nutrient interactions and risk of coronary heart disease." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Malik, Iqbal Saeed. "Assessment of the inflammatory burden in coronary heart disease." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542947.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Bhattacharyya, M. R. "Psychological and biological factors in acute coronary heart disease." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444164/.

Full text

Abstract:

Psychosocial factors are thought to contribute to the long term development of coronary artery disease (CAD), to the triggering of cardiac events in people with advanced disease, and to adaptation following acute coronary syndromes (ACS). My thesis presents three studies addressing different aspects of the relationship between emotional factors and CAD, using different methodologies. They focus on the role of negative emotions in vulnerability to myocardial ischaemia in daily life, the influence of acute emotional triggers of ACS on long term quality of life, and the effect of depression following ACS on a particularly important aspect of adaptation, namely return to work. The first study, called the Silent Ischaemia Study (SIS) investigated 88 out-patients with suspected CAD who underwent 24 hour ambulatory electrocardiogram (ECG) monitoring, together with saliva sampling and characterisation of daily life by a new method called the Day Reconstruction Method (DRM). The results indicated that in patients with definite CAD, depressed mood was associated with reduced high frequency and increased low frequency heart rate variability (HRV), suggestive of parasympathetic withdrawal. The Cortisol slope over the day was flatter in more depressed patients with CAD. Episodes of transient ischaemia and/or arrhythmia were also associated with increased negative affect, but their incidence was low, primarily because most patients were medicated with beta blockers. The second and third studies derive from the ACCENT (Acute Coronary Syndrome, Emotion and Triggers) study, exploring long term adaptation following ACS. Analyses showed that the likelihood of returning to work was negatively associated with depression immediately following ACS, independently of clinical and demographic factors, and that emotional triggers predicted elevated anxiety and poor mental health status at 12 and 36 months independently of covariates. In combination, these studies suggest that negative emotional status contribute both to the onset of acute cardiac events, and to adaptation following ACS.

APA, Harvard, Vancouver, ISO, and other styles

43

Meng, Weihua. "Investigation of the genetic basis of coronary heart disease." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501377.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Waterhouse, Anna. "Bioengineering a coronary stent with covalently immobilised tropoelastin." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28916.

Full text

Abstract:

This thesis describes the characterisation and development of covalently immobilised recombinant human tropoelastin (TE) on a plasma-activated coating (PAC) as a potential stent coating for the treatment of coronary artery disease. A biomimetic approach was used to create a biocompatible coating with an immobilised human protein to enhance biointegration of an implanted stent. A coating that enhanced endothelialisation while displaying low tbrombogenicity was developed and characterised in vitro and in vivo. Covalent binding of TE to PAC was verified using ELISA and radiolabelled TE. Modulating the gas composition of the PAC, and therefore its mechanical and biological properties, resulted in varying amounts of covalently bound TE. The nitrogen containing PA Cs covalently bound up to 89± 1 % of physisorbed TE. The N2/Ar PAC covalently bound a monolayer of TE and was chosen for further characterisation. The covalent binding capacity of PAC extended for at least a year, retaining 65±1 % of its covalent TE binding capacity. Restoration of the full covalent binding capacity was achieved upon heat treatment of the PAC. TE was shown to support the attachment and proliferation of endothelial cells (ECs) when physisorbed to tissue culture plastic (TCP). This was comparable to other adhesive extracellular matrix proteins, fibronectin and collagen. The morphology and distribution of ECs cultured on 316L SS, PAC and PAC+TE was investigated using reflective, fluorescence and scanning electron microscopy. PAC+TE supported increased endothelial attachment and proliferation compared to uncoated 3 l 6L SS and PAC. An EC phenotype was confirmed on 316L SS, PAC and PAC+TE by immunofluorescent labelling of endothelial cell specific markers, CD3 I and vWF. As the thrombogenicity of blood contacting medical devices is crucial, methodology was developed to test the haemocompatibility of metallic surfaces in vitro. In static adhesion assays using whole heparinised blood, PAC was found to confer low thrombogenicity compared to 3 l 6L SS, and nitrogen again modulated this property. PAC and PAC+TE showed lower thrombogenicity than 316L SS after 60 min incubation. A modified Chandler loop was developed to test the tbrombogenicity of metallic surfaces in the presence of flowing blood. PAC and PAC+TE were again found to display low thrombogenicity, resulting in a 3-fold increase in the time to thrombus formation compared to 3 I 6L SS. This effect correlated with a 65±1 % increase in soluble P-selectin, a platelet activation marker on 3 l 6L SS. No significant platelet activation occurred on PAC or PAC+TE. The low thrombogenicity of PAC was retained for between 3 and 7 months. Furthermore, TE coated 3 I 6L SS displayed lower thrombogenicity than uncoated 316L SS, or fibronectin-or collagen-coated 316L SS. The PAC was translated to a 316L SS laser cut stent for evaluation and in vivo testing. The PAC deposition was altered to coat all surfaces and resisted delamination. In vitro crimping and expansion of the PAC stent showed only the formation of nanocracks, compared to the large scale delamination observed on a commercially available Taxus Liberte stent. The covalent TE binding capacity and non-thrombogenicity of the PAC were maintained on the stent PAC. The endothelialisation of PAC and PAC+TE stents was evaluated in vivo. This study marks the first comparator analysis of bare metal stents (BMS), PAC and PAC+ TE stents in a well-characterised model of rabbit bilateral iliac stenting. PAC and PAC+ TE stents were well tolerated and showed no gross inflammatory response. Cell coverage of stent struts occurred by 7 days post-implantation with endotheJialisation occurring both between the struts and over the struts in all samples. PAC and PAC+ TE showed no difference in the rate of endothelialisation compared to BMS, the standard corrunerciaJly available stents. In further work, covalently immobilised TE was found to be susceptible to proteolytic cleavage by the common blood plasma proteases kallikrein and thrombin, which predominantly cleave TE at its arginine 515 residue. A mutant form of TE, R5 I 5A was shown to resist proteolytic cleavage at the 515 residue and thus retained the C-terminus of the protein which is required for cell attachment. This mutant form of TE retained the equivalent level of covalent binding to PAC and would therefore be a suitable candidate for application to a PAC stent for in vivo evaluation.

APA, Harvard, Vancouver, ISO, and other styles

45

Warner, Anke Sigrid. "The expression, regulation and effects of inducible nitric oxide synthase in hibernating myocardium." Title page, contents and summary only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phw279.pdf.

Full text

Abstract:

Amendments inserted at back. "May 2002" Includes bibliographical references (leaves 237-290) Experiments described in this thesis address the potential role of inducible nitric oxide synthase (iNOS) in hibernating myocardium. Specifically it was sought to establish a cellular model of hibernating myocardium and investigate the expression, regulation and effects of iNOS in this model. Experiments were performed using primary cultures of neonatal rat ventricular myocytes.

APA, Harvard, Vancouver, ISO, and other styles

46

Cao, Fei. "Chlamydia pneumoniae, toll-like receptors and pathogenesis of atherosclerotic heart disease." View the abstract Download the full-text PDF version (on campus access only), 2007. http://etd.utmem.edu/ABSTRACTS/2007-022-Cao-index.html.

Full text

Abstract:

Thesis (Ph.D. )--University of Tennessee Health Science Center, 2007.
Title from title page screen (viewed on May 16, 2008 ). Research advisor: Gerald I. Byrne, Ph.D. Document formatted into pages (xi, 114 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 65-107).

APA, Harvard, Vancouver, ISO, and other styles

47

Jenneke, Cindy A. N. "The effect of dietary patterns on risk factors for CHD : a comparative study of students residing at the Adventist International Institute of Advanced Studies in the Philippines." Thesis, Link to online version, 2006. http://hdl.handle.net/10019/554.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Ninomiya, John Koichi. "Non-invasive measures of peripheral arterial disease as predictors of coronary heart and cerebrovascular disease morbidity and mortality /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189029.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Schulz, Katharine I. "Coping strategies in coronary artery disease patients." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/862273.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Rahmani, Sadoh Danesi. "Immune responses to heat shock proteins in chronic periodontitis and coronary heart disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413239.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!