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Yulianto, Agus. "INTERPRETASI SIMBOL DALAM CERPEN CORAT-CORET DI TOILET KARYA EKA KURNIAWAN." Kadera Bahasa 9, no. 1 (February 26, 2018): 27–38. http://dx.doi.org/10.47541/kaba.v9i1.3.
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The purpose of this study is to find out the forms of symbols and meanings in the short story Corat-Coret di Toilet.Thus, the problem of this study is how the form of symbols and what are the meanings in the story Corat-Coret diToilet. This research uses semiotic structural approach with qualitative method. The data of this research are the symbolsfound in short story Corat-Coret di Toilet. These symbols are then interpreted into meanings. Based on the analysis, itcan be seen there are eight symbols in the analyzed short story found in the campus toilet wall where the walls have fullof graffiti as the symbols of shackles intellectual and marginalized aspirations. AbstrakTujuan penelitian ini untuk mengetahui bentuk-bentuk simbol yang terdapat dalam cerpen Corat-Coretdi Toilet serta makna yang dikandungnya. Dengan demikian, masalah dalam penelitian ini adalahbagaimanakah bentuk simbol-simbol yang terdapat dalam cerpen Corat-Coret di Toilet dan apa maknanya.Penelitian ini menggunakan pendekatan struktural semiotik dengan metode kualitatif. Data penelitianini adalah simbol-simbol yang terdapat dalam cerpen Corat-Coret di Toilet. Simbol-simbol ini kemudiandiinterpretasikan berupa makna-makna. Berdasarkan hasil analisis dapat diketahui bahwa terdapatdelapan simbol dalam cerpen yang dianalisis salah satunya adalah dinding toilet kampus yang penuhdengan coretan dengan sendirinya merupakan simbol yang mengandung makna terpasungnya aspirasiintelektual dan termarginalkannya aspirasi tersebut.
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Falbo, Caterina. "La collecte de corpus d’interprétation : un défi permanent." Meta 63, no. 3 (June 6, 2019): 649–64. http://dx.doi.org/10.7202/1060167ar.
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Depuis l’article programmatique de Shlesinger (1998), beaucoup de corpus d’interprétation ont vu le jour. Il s’agit de corpus constitués d’interprétations effectuées dans des contextes de conférences, dans le domaine médical, ou encore dans des situations institutionnelles comme la télévision. Malgré les différences portant sur le contexte situationnel, ils présentent des traits communs sur le plan de leur dimension, qui est en général limitée, et de leur exploitation, qui est, quant à elle, conditionnée par la présence ou l’absence de l’alignement des transcriptions avec l’audio ou l’image, de même que par le niveau d’étiquetage choisi. Nous nous proposons de réfléchir à ces aspects, en illustrant brièvement les caractéristiques de deux corpus collectés à l’Université de Trieste tels que CorIT (corpus d’interprétation à la télévision italienne) et CorILex (corpus d’interprétation judiciaire) et en mettant en évidence les obstacles qui ont entravé ou qui conditionnent leur collecte. Nos remarques conclusives porteront enfin sur les traits qui différencient ces deux corpus dans le but de les articuler avec les réflexions qui se sont développées au sein de la linguistique de corpus afin de déterminer la place des corpus d’interprétation à l’intérieur d’un domaine qui se montre de plus en plus diversifié, hétérogène et interdisciplinaire.
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Furoidah, Asri, and Alberta Natasia Adji. "BENTUK KOMUNIKASI TEKS PADA KUMPULAN CERPEN CORAT-CORET DI TOILET KARYA EKA KURNIAWAN." RETORIKA: Jurnal Bahasa, Sastra, dan Pengajarannya 12, no. 1 (February 27, 2019): 1. http://dx.doi.org/10.26858/retorika.v12i1.6891.
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The Form of Text Communication in Eka Kurniawan’s Corat-coret di Toilet Short Story Collection. The purpose of this study is to find the method of text communication in the Corat-coret di Tolet short stories collection. The form of this study is a literary study with structural analysis methods as offered in the narrative theory of Gerard Gennette. The results of the study are the classification of the text communication method of short stories namely: zero and fixed internal focalization; subsequent and simultaneous narrating times; intradiegetic-heterodiegetic, extradiegetic-heterodiegetic, and intradiegetic-homodiegetic types of narrating level and person; the character and writer as a narrator. The findings of the classification of text communication methods indicate the existence of a gender bias that alienates women's position in the story.
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Prasetyo, M. Taher Agus. "Cerpen “Corat-Coret di Toilet†Karya Eka kurniawan Sebagai Alternatif Bahan Literasi." Deiksis : Jurnal Pendidikan Bahasa dan Sastra Indonesia 4, no. 1 (May 1, 2017): 41. http://dx.doi.org/10.33603/deiksis.v4i1.403.
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Cerpen merupakan jenis karya sastra yang memaparkan kisah ataupun cerita tentang kehidupan manusia lewat tulisan pendek. Dalam upaya membiasakan siswa membaca dan melestarikan budaya literasi, cerpen yang menarik, mengedukasi, dan bahasanya mudah dipahami siswa perlu dikenalkan oleh guru. Sehubungan dengan itu, cerpen “Corat-coret di Toilet†karya Eka Kurniawan bisa dijadikan bahan alternatif literasi pada siswa jenjang SMA karena memuat tiga poin penting yakni menarik, mengedukasi, dan bahasanya mudah dipahami.Kata Kunci : Cerpen, Corat-coret di toilet, literasi sejarah
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Maulida, Lailatul. "Reformasi Gagal Total, Kawan!: A Stylistics Study of Political Satire in Eka Kurniawan’s Corat-coret di Toilet." Aphorisme: Journal of Arabic Language, Literature, and Education 1, no. 1 (April 4, 2020): 54–64. http://dx.doi.org/10.37680/aphorisme.v1i1.321.
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This paper aims to discuss and analyze political satire in Eka Kurniawan's short story titled Corat-coret di Toilet. By applying descriptive qualitative research as well as stylistics approach, researcher then reading the whole text of the short story, analyzing the political satire, and taking notes the sentence related to political satire inside. Found that there are nine sentences of satire in the short story that refer to political satire that was written by some students on the campus toilet's walls against the situation of the government in the year of 1990s where the freedom of conveying aspirations is tightly limited. The ubiquity of political satire in this short story builds critical thinking on the readers and also stimulates them intensely to be able to interpretatively understand what is meant by the political satire, the relation of those political satires with the political and social condition in Indonesia, specifically in the end of New Order and the beginning of reform era. Finally, the political satire in Corat-coret di Toilet reflects legal and social injustice in Indonesia. Nevertheless, Kurniawan's work able to persuade the readers with a sense of humor, sadness, anger and the truth of the Indonesian situation, to understand and care more about social and government phenomena in their own country.
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Seynaeve, Ysaline, Justine Heylen, Corentin Fontaine, François Maclot, Cécile Meex, Anh Nguyet Diep, Anne-Françoise Donneau, Marie-Pierre Hayette, and Julie Descy. "Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs." Journal of Clinical Medicine 10, no. 13 (June 24, 2021): 2774. http://dx.doi.org/10.3390/jcm10132774.
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(1) Background: In the current context of the COVID-19 crisis, there is a need for fast, easy-to-use, and sensitive diagnostic tools in addition to molecular methods. We have therefore decided to evaluate the performance of newly available antigen detection kits in “real-life” laboratory conditions. (2) Methods: The sensitivity and specificity of two rapid diagnostic tests (RDT)—the COVID-19 Ag Respi-Strip from Coris Bioconcept, Belgium (CoRDT), and the coronavirus antigen rapid test cassette from Healgen Scientific, LLC, USA (HeRDT)—were evaluated on 193 nasopharyngeal samples using RT-PCR as the gold standard. (3) Results: The sensitivity obtained for HeRDT was 88% for all collected samples and 91.1% for samples with Ct ≤ 31. For the CoRDT test, the sensitivity obtained was 62% for all collected samples and 68.9% for samples with Ct ≤ 31. (4) Conclusions: Despite the excellent specificity obtained for both kits, the poor sensitivity of the CoRDT did not allow for its use in the rapid diagnosis of COVID-19. HeRDT satisfied the World Health Organization’s performance criteria for rapid antigen detection tests. Its high sensitivity, quick response, and ease of use allowed for the implementation of HeRDT at the laboratory of the University Hospital of Liège.
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Furoidah, Asri. "WOMEN RESISTANCE IN EKA KURNIAWAN’S CORAT-CORET DI TOILET SHORT STORY COMPILATION BOOK." PARADIGM 2, no. 1 (June 29, 2019): 71. http://dx.doi.org/10.18860/prdg.v2i1.6847.
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<p>Eka Kurniawan's Corat-coret di Toilet short stories compilation book contains twelve short stories that tell about light stories everyday but full of social criticism. Some of the short stories that portrayed female characters presented women who were not free in their lives, one of which was titled Dongeng Sebelum Bercinta and Si Cantik yang Tak Boleh Keluar Malam. Therefore, this study aims to analyze the position of women and their resistance toward patriarchal domination. This is interesting to be studied further by using feminist theory to find the position of women in literary works written by male writers. This research will focus on the actions of female characters which shape their position in the story. The data used in this study are in the form of words, sentences or expressions from short stories that show the dominance of patriarchy towards women and their efforts to get out of domination. From research using feminist theory it was found that patriarchal domination arises in the closest male characters to female characters such as fathers, male friends and husbands. Women resistance in the story was a form of false resistance which in turn strengthened the dominance of patriarchy and the dichotomy between men and women. This was found based on the fact that every resistance made by women turned to weaken women themselves.</p><p> <em> </em></p>
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Raetz, St, A. M. Heras, M. Fernández, V. Casanova, and C. Marka. "Transit analysis of the CoRoT-5, CoRoT-8, CoRoT-12, CoRoT-18, CoRoT-20, and CoRoT-27 systems with combined ground- and space-based photometry." Monthly Notices of the Royal Astronomical Society 483, no. 1 (November 15, 2018): 824–39. http://dx.doi.org/10.1093/mnras/sty3085.
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Zamora Pérez, Elisa Costanza. "Maria Corti, "Catasto Mágico"." Philologia Hispalensis 1, no. 17 (2003): 271–73. http://dx.doi.org/10.12795/ph.2003.v17.i01.17.
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Munsterberg, Marjorie, and Peter Galassi. "Corot." Art Journal 51, no. 1 (1992): 113. http://dx.doi.org/10.2307/777262.
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STUDIO, IAIN GALE. "COROT." Art Book 1, no. 3 (June 1994): 15d. http://dx.doi.org/10.1111/j.1467-8357.1994.tb00119.x.
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WINDLE, PAMELA E., and SUSAN HOUSTON. "COMIT." Nursing Management (Springhouse) 26, no. 9 (September 1995): 64G. http://dx.doi.org/10.1097/00006247-199509000-00013.
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Hone, Kate S., Máire Kerrin, and Tom Cox. "CORDiT." European Psychologist 3, no. 3 (September 1998): 227–37. http://dx.doi.org/10.1027/1016-9040.3.3.227.
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Armaly, Zaher, Suheir Assady, and Zaid Abassi. "Corin." Current Opinion in Nephrology and Hypertension 22, no. 6 (November 2013): 713–22. http://dx.doi.org/10.1097/01.mnh.0000435609.35789.32.
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Liao, Xudong, Wei Wang, Shenghan Chen, and Qingyu Wu. "Role of Glycosylation in Corin Zymogen Activation." Journal of Biological Chemistry 282, no. 38 (July 27, 2007): 27728–35. http://dx.doi.org/10.1074/jbc.m703687200.
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The cardiac serine protease corin is the pro-atrial natriuretic peptide convertase. Corin is made as a zymogen, which is activated by proteolytic cleavage. Previous studies showed that recombinant human corin expressed in HEK 293 cells was biologically active, but activated corin fragments were not detectable, making it difficult to study corin activation. In this study, we showed that recombinant rat corin was activated in HEK 293 cells, murine HL-1 cardiomyocytes, and rat neonatal cardiomyocytes. In these cells, activated corin represented a small fraction of the total corin molecules. The activation of recombinant rat corin was inhibited by small molecule trypsin inhibitors but not inhibitors for matrix metalloproteinases or cysteine proteases, suggesting that a trypsin-like protease activated corin in these cells. Glycosidase digestion showed that rat and human corin proteins contained substantial N-glycans but little O-glycans. Treatment of HEK 293 cells expressing rat corin with tunicamycin prevented corin activation and inhibited its pro-atrial natriuretic peptide processing activity. Similar effects of tunicamycin on endogenous corin activity were found in HL-1 cells. Mutations altering the two N-glycosylation sites in the protease domain of rat corin prevented its activation in HEK 293 and HL-1 cells. Our results indicate that N-linked oligosaccharides play an important role in corin activation.
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Fang, Chaodong, Lei Shen, Liang Dong, Meng Liu, Sensen Shi, Ningzheng Dong, and Qingyu Wu. "Reduced urinary corin levels in patients with chronic kidney disease." Clinical Science 124, no. 12 (February 26, 2013): 709–17. http://dx.doi.org/10.1042/cs20120517.
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Corin is a cardiac protease that regulates BP (blood pressure) by activating natriuretic peptides. Recent animal studies identified corin expression in the kidney where it may regulate renal function. In the present study, we tested the hypothesis that corin may be present in human urine and that urinary corin levels may be altered in patients with kidney disease. We obtained urine and kidney tissue samples from normal individuals and CKD (chronic kidney disease) patients. Using ELISA, we detected corin protein in human urine. In normal individuals, urinary corin levels did not correlate with that of plasma, indicating that urinary corin is probably of kidney origin. Compared with normal controls, CKD patients had markedly reduced urinary corin levels and this reduction correlated with disease severity. By immunostaining, human corin protein was identified on the epithelial cell surface in renal tubules. The renal corin mRNA and protein levels were significantly lower in CKD patients than non-CKD controls. The results indicate that renal tubular corin may be shed into urine and that urinary and renal corin levels were reduced in CKD patients. These data suggest that reduced corin levels in the kidney may reflect the underlying pathology in CKD.
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Dong, Ningzheng, Yayan Niu, Yue Chen, Shijin Sun, and Qingyu Wu. "Function and regulation of corin in physiology and disease." Biochemical Society Transactions 48, no. 5 (October 14, 2020): 1905–16. http://dx.doi.org/10.1042/bst20190760.
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Atrial natriuretic peptide (ANP) is of major importance in the maintenance of electrolyte balance and normal blood pressure. Reduced plasma ANP levels are associated with the increased risk of cardiovascular disease. Corin is a type II transmembrane serine protease that converts the ANP precursor to mature ANP. Corin deficiency prevents ANP generation and alters electrolyte and body fluid homeostasis. Corin is synthesized as a zymogen that is proteolytically activated on the cell surface. Factors that disrupt corin folding, intracellular trafficking, cell surface expression, and zymogen activation are expected to impair corin function. To date, CORIN variants that reduce corin activity have been identified in hypertensive patients. In addition to the heart, corin expression has been detected in non-cardiac tissues, where corin and ANP participate in diverse physiological processes. In this review, we summarize the current knowledge in corin biosynthesis and post-translational modifications. We also discuss tissue-specific corin expression and function in physiology and disease.
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Tripathi, Ranjana, Ryan D. Sullivan, Tai-Hwang M. Fan, Aiilyan K. Houng, Radhika M. Mehta, Guy L. Reed, and Inna P. Gladysheva. "Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy." International Journal of Molecular Sciences 21, no. 1 (December 27, 2019): 203. http://dx.doi.org/10.3390/ijms21010203.
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Humans with dilated cardiomyopathy (DCM) and heart failure (HF) develop low levels of corin, a multi-domain, cardiac-selective serine protease involved in natriuretic peptide cleavage and sodium and water regulation. However, experimental restoration of corin levels markedly attenuates HF progression. To determine whether the beneficial effects of corin in HF require catalytic activity, we engineered cardiac overexpression of an enzymatically inactive corin transgene (corin-Tg(i)). On a wild-type (WT) background, corin-Tg(i) had no evident phenotypic effects. However, in a well-established genetic model of DCM, corin-Tg(i)/DCM mice had increased survival (p < 0.01 to 0.001) vs. littermate corin-WT/DCM controls. Pleural effusion (p < 0.01), lung edema (p < 0.05), systemic extracellular free water (p < 0.01), and heart weight were decreased (p < 0.01) in corin-Tg(i)/DCM vs. corin-WT/DCM mice. Cardiac ejection fraction and fractional shortening improved (p < 0.01), while ventricular dilation decreased (p < 0.0001) in corin-Tg(i)/DCM mice. Plasma atrial natriuretic peptide, cyclic guanosine monophosphate, and neprilysin were significantly decreased. Cardiac phosphorylated glycogen synthase kinase-3β (pSer9-GSK3β) levels were increased in corin(i)-Tg/DCM mice (p < 0.01). In summary, catalytically inactive corin-Tg(i) decreased fluid retention, improved contractile function, decreased HF biomarkers, and diminished cardiac GSK3β activity. Thus, the protective effects of cardiac corin on HF progression and survival in experimental DCM do not require the serine protease activity of the molecule.
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Jiang, Jingjing, Shannon Wu, Wei Wang, Shenghan Chen, Jianhao Peng, Xiumei Zhang, and Qingyu Wu. "Ectodomain Shedding and Autocleavage of the Cardiac Membrane Protease Corin." Journal of Biological Chemistry 286, no. 12 (February 2, 2011): 10066–72. http://dx.doi.org/10.1074/jbc.m110.185082.
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Corin is a cardiac membrane protease that activates natriuretic peptides. It is unknown how corin function is regulated. Recently, soluble corin was detected in human plasma, suggesting that corin may be shed from cardiomyocytes. Here we examined soluble corin production and activity and determined the proteolytic enzymes responsible for corin cleavage. We expressed human corin in HEK 293 cells and detected three soluble fragments of ∼180, ∼160, and ∼100 kDa, respectively, in the cultured medium by Western blot analysis. All three fragments were derived from activated corin molecules. Similar results were obtained in HL-1 cardiomyocytes. Using protease inhibitors, ionomycin and phorbol myristate acetate stimulation, small interfering RNA knockdown, and site-directed mutagenesis, we found that ADAM10 was primarily responsible for shedding corin in its juxtamembrane region to release the ∼180-kDa fragment, corresponding to the near-entire extracellular region. In contrast, the ∼160- and ∼100-kDa fragments were from corin autocleavage at Arg-164 in frizzled 1 domain and Arg-427 in LDL receptor 5 domain, respectively. In functional studies, the ∼180-kDa fragment activated atrial natriuretic peptide, whereas the ∼160- and ∼100-kDa fragments did not. Our data indicate that ADAM-mediated shedding and corin autocleavage are important mechanisms regulating corin function and preventing excessive, potentially hazardous, proteolytic activities in the heart.
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Syuhada, Aldy Maulana. "Kajian Perbandingan Cobit 5 dengan Cobit 2019 sebagai Framework Audit Tata Kelola Teknologi Informasi." Syntax Literate ; Jurnal Ilmiah Indonesia 6, no. 1 (January 20, 2021): 30. http://dx.doi.org/10.36418/syntax-literate.v6i1.2082.
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Teknologi Informasi atau biasa disebut TI merupakan hal terpenting bagi kemajuan perusahaan, semakin berkembangkan TI maka harus dilakukan tata kelola TI yang baik sesuai dengan standart yang ada dan harus dievaluasi terus menerus. Salah satu cara untuk mengevaluasi tata kelola TI yaitu dengan dilakukanya audit teknologi informasi. Salah satu framework yang sering digunakan untuk melakukan audit tata kelola TI adalah COBIT. Tujuan dari penelitian ini adalah mengetahui perbandingan antara COBIT 5 dengan COBIT 2019 serta mengetahui kekurangan dan kelebihan dari masing-masing COBIT tersebut. Metode yang digunakan yaitu kualitatif dengan studi literatur yang berisi tentang uraian teori, temuan dan bahan penelitian lain yang diperoleh sebagai acuan untuk dijadikan landasan kegiatan penelitian. Hasil yang diperoleh dari penelitian ini yaitu terdapat beberapa perbedaan dari segi gambaran secara umum pada COBIT 2019 memiliki desain faktor, segi domain, pada COBIT 2019 terdapat tiga domain tambahan dan bersifat objective. Selanjutnya dari segi prinsip COBIT 2019 memiliki 9 prinsip yang telah dikembangkan dari COBIT sebelumnya. Selanjutnya dari goal cascade dan dari perhitungan kinerja, COBIT 5 hanya menggunakan capability level tetapi pada COBIT 2019 adanya penambahan menjadi capability level dan maturity level. Dari segi kelebihan COBIT 5 lebih banyak digunakan sedangkan dari kekurangannya tidak bersifat flexible sedangkan COBIT 2019 kelebihannya lebih bersifat flexible dan kekurannya prinsip dan detail domainya lebih banyak sehingga akan lebih sulit dalam implementasi.
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Guggenheim, Jean. "Le Corot." Champ psychosomatique 25, no. 1 (2002): 129. http://dx.doi.org/10.3917/cpsy.025.0129.
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Zhou, Tiantian, Shengnan Zhang, Chunyu Du, Kun Wang, Xiabing Gu, Shijin Sun, Xianrui Zhang, et al. "Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis." International Journal of Molecular Sciences 23, no. 19 (September 24, 2022): 11251. http://dx.doi.org/10.3390/ijms231911251.
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Atrial natriuretic peptide (ANP)-mediated natriuresis is known as a cardiac endocrine function in sodium and body fluid homeostasis. Corin is a protease essential for ANP activation. Here, we studied the role of renal corin in regulating salt excretion and blood pressure. We created corin conditional knockout (cKO), in which the Corin gene was selectively disrupted in the kidney (kcKO) or heart (hcKO). We examined the blood pressure, urinary Na+ and Cl− excretion, and cardiac hypertrophy in wild-type, corin global KO, kcKO, and hcKO mice fed normal- and high-salt diets. We found that on a normal-salt diet (0.3% NaCl), corin kcKO and hcKO mice had increased blood pressure, indicating that both renal and cardiac corin is necessary for normal blood pressure in mice. On a high-salt diet (4% NaCl), reduced urinary Na+ and Cl− excretion, increased body weight, salt-exacerbated hypertension, and cardiac hypertrophy were observed in corin kcKO mice. In contrast, impaired urinary Na+ and Cl− excretion and salt-exacerbated hypertension were not observed in corin hcKO mice. These results indicated that renal corin function is important in enhancing natriuresis upon high salt intakes and that this function cannot be compensated by the cardiac corin function in mice.
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Ichiki, Tomoko, Brenda K. Huntley, Denise M. Heublein, Sharon M. Sandberg, Paul M. McKie, Fernando L. Martin, Michihisa Jougasaki, and John C. Burnett. "Corin Is Present in the Normal Human Heart, Kidney, and Blood, with Pro–B-Type Natriuretic Peptide Processing in the Circulation." Clinical Chemistry 57, no. 1 (January 1, 2011): 40–47. http://dx.doi.org/10.1373/clinchem.2010.153908.
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BACKGROUND B-type natriuretic peptide (BNP), which is activated in heart failure (HF), is processed to an active form by corin. The corin gene is expressed in the human heart and kidney, but corin protein expression in the heart, kidney, and circulation, along with whether proBNP is processed by circulating corin, remains unknown. METHODS We examined corin protein expression by immunostaining and Western blot in human heart and kidney, and we assessed the circulating corin concentration by ELISA. We examined histidine-tagged (His-tag) proBNP1–108 processing in serum and plasma by immunoprecipitation and Western blot and sequenced the processed form. RESULTS Normal human heart and kidney displayed the presence of corin, especially in cells around the vasculature. Both corin and proBNP1–108 were present in the plasma of healthy human subjects, with circulating corin significantly higher in men than women (P < 0.0001) and a positive correlation of corin to age (P = 0.0497, r = 0.27). In fresh normal plasma and serum, His-tag proBNP1–108 was processed to a lower molecular weight form confirmed to be BNP. Processed BNP was higher in men than women (P = 0.041) and was positively correlated to plasma corin concentrations (P = 0.041, r = 0.65). CONCLUSIONS Our results support the concept that proBNP1–108 may be processed outside of the heart in the circulation where the proprotein convertase is present. Moreover, sex may impact this process, since corin concentrations are higher in men. These findings may have important physiologic and pathophysiologic implications for the proBNP/corin system in the human.
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Yan, Wei, Faye Wu, John Morser, and Qingyu Wu. "Corin, a Transmembrane Cardiac Serine Protease, as a Pro-Atrial Natriuretic Peptide Convertase." Hypertension 36, suppl_1 (October 2000): 709–10. http://dx.doi.org/10.1161/hyp.36.suppl_1.709-e.
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P92 Atrial natriuretic peptide (ANP) is a cardiac hormone that reduces high blood pressure by promoting salt excretion, decreasing blood volume and relaxing vessel tension. It is implicated in major cardiovascular diseases such as hypertension and congestive heart failure. In cardiomyocytes, ANP is synthesized as a precursor, pro-ANP, that is converted to biologically active ANP by an unknown membrane-associated serine protease. Recently, we cloned a novel cardiac serine protease, corin, that has the predicted structure of a type II transmembrane protein. Northern and in situ hybridization detected corin mRNA in the heart where its expression was most abundant in cardiomyocytes of the atrium. Corin mRNA was also detected in developing kidney and bones. The overall expression pattern of corin mRNA was very similar to that of ANP, leading to our hypothesis that corin is the pro-ANP convertase. To test this hypothesis, we constructed expression vectors for both human corin and pro-ANP. Recombinant corin and pro-ANP were expressed in human 293 cells. Effects of corin on pro-ANP processing was examined by western analysis. The results showed that human corin, but not control proteases prothrombin and hepsin, converted pro-ANP to ANP in the cell-based experiments. To determine sequence specificity of corin-mediated cleavage in pro-ANP, we constructed a mutant pro-ANP R98G in which the predicted cleave site residue Arg98 was replaced with a Gly. In co-transfection experiments, corin processed wild-type pro-ANP but not mutant pro-ANP R98G, indicating that corin-mediated cleavage in pro-ANP is highly sequence specific. We also examined effects of protease inhibitors on processing of pro-ANP by corin. Our results showed that the activity of corin was inhibited by aprotinin, benzamidine and leupeptin but not soybean trypsin inhibitor. Similar effects of these proteases on pro-ANP processing were reported previously. Thus, corin matches all known characteristics of the long-sought pro-ANP convertase. Identification of corin as the pro-ANP convertase suggests a new regulatory mechanism for the ANP-mediated pathway that is important for controlling blood pressure.
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Bordé, P., R. F. Díaz, O. Creevey, C. Damiani, H. Deeg, P. Klagyivik, G. Wuchterl, et al. "Transiting exoplanets from the CoRoT space mission." Astronomy & Astrophysics 635 (March 2020): A122. http://dx.doi.org/10.1051/0004-6361/201732393.
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Aims. We report the discovery as well as the orbital and physical characterizations of two new transiting giant exoplanets, CoRoT-30 b and CoRoT-31 b, with the CoRoT space telescope. Methods. We analyzed two complementary data sets: photometric transit light curves measured by CoRoT, and radial velocity curves measured by the HARPS spectrometer. To derive the absolute masses and radii of the planets, we modeled the stars from available magnitudes and spectra. Results. We find that CoRoT-30 b is a warm Jupiter on a close-to-circular 9.06-day orbit around a G3V star with a semi-major axis of about 0.08 AU. It has a radius of 1.01 ± 0.08 RJ, a mass of 2.90 ± 0.22 MJ, and therefore a mean density of 3.45 ± 0.65 g cm−3. The hot Jupiter CoRoT-31 b is on a close-to-circular 4.63-day orbit around a G2 IV star with a semi-major axis of about 0.05 AU. It has a radius of 1.46 ± 0.30 RJ, a mass of 0.84 ± 0.34 MJ, and therefore a mean density of 0.33 ± 0.18 g cm−3. Conclusions. Neither system seems to support the claim that stars hosting planets are more depleted in lithium. The radii of both planets are close to that of Jupiter, but they differ in mass; CoRoT-30 b is ten times denser than CoRoT-31 b. The core of CoRoT-30 b would weigh between 15 and 75 Earth masses, whereas relatively weak constraints favor no core for CoRoT-31 b. In terms of evolution, the characteristics of CoRoT-31 b appear to be compatible with the high-eccentricity migration scenario, which is not the case for CoRoT-30 b. The angular momentum of CoRoT-31 b is currently too low for the planet to evolve toward synchronization of its orbital revolution with stellar rotation, and the planet will slowly spiral-in while its host star becomes a red giant. CoRoT-30 b is not synchronized either: it looses angular momentum owing to stellar winds and is expected reach steady state in about 2 Gyr. CoRoT-30 and 31, as a pair, are a truly remarkable example of diversity in systems with hot Jupiters.
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., Emas, Undang Sudarsana, and Novi Widya. "UPAYA PUSTAKAWAN DALAM MENGATASI VANDALISME." Nusantara - Journal of Information and Library Studies 1, no. 1 (January 1, 2018): 52. http://dx.doi.org/10.30999/n-jils.v1i1.271.
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Vandalisme di perpustakaan merupakan tindakan perusakan yang dilakukan oleh manusia terhadap koleksi maupun fasilitas yang ada di perpustakaan. Bentuk dari tindakan vandalisme terhadap bahan pustaka diantaranya corat coret, menandai dengan bolpoint atau stabilo, memberi tanda sebagai batas baca, melipat bahan pustaka, merobek, mengambil sebagian halaman bahan pustaka, menggunting gambar, mencopot stiker, penambahan tulisan serta mengotori bahan pustaka. Perpustakaan sekolah tidak terlepas dari bahaya vandalisme, salah satunya tindakan perobekan terhadap bahan pustaka. Hal yang dapat dilakukan pustakawan dalam mengatasi perobekan bahan pustaka yaitu dengan mengadakan kegiatan sosialisasi, melakukan kerjasama dengan guru kelas, melakukan kerjasama dengan orang tua siswa dan memberikan sanksi yang tegas terhadap pelaku perobekan bahan pustaka. ABSTRACT Vandalism in the library is an act of destcution committed by humans agains collection or facilities in the library. The form of vandalism against library materials such as scribbled marks, marked with ballpoint or highlighter, gave punctuation marks, forl library materials, rips, tore the page, removes stickers, attaches additives and contaminates library materials. The school library is inseparable from the dangers of vandalism, one of the act is tapping the materials. The things that librarians can do in overcoming library materials is by holding socialization activities, cooperating with teachers, parents and giving strict sanctions against the perpetrators of tapping library materials.
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Bonomo, Aldo S., Pierre-Yves Chabaud, Magali Deleuil, Claire Moutou, and Pascal Bordé. "Detection of small-size planetary candidates with CoRoT data." Proceedings of the International Astronomical Union 6, S276 (October 2010): 523–24. http://dx.doi.org/10.1017/s1743921311021065.
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AbstractWith the discovery of CoRoT-7b, the first transiting super-Earth, the CoRoT space mission has shown the capability to detect short-period rocky planets around solar-like stars. By performing a blind test with real CoRoT light curves, we want to establish the detection threshold of small-size planets in CoRoT data. We investigate the main obstacles to the detection of transiting super-Earths in CoRoT data, notably the presence of short-time scale variability and hot pixels.
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Zhang, Xianrui, Wenguo Li, Tiantian Zhou, Meng Liu, Qingyu Wu, and Ningzheng Dong. "Corin Deficiency Alters Adipose Tissue Phenotype and Impairs Thermogenesis in Mice." Biology 11, no. 8 (July 23, 2022): 1101. http://dx.doi.org/10.3390/biology11081101.
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Atrial natriuretic peptide (ANP) is a key regulator in body fluid balance and cardiovascular biology. In addition to its role in enhancing natriuresis and vasodilation, ANP increases lipolysis and thermogenesis in adipose tissue. Corin is a protease responsible for ANP activation. It remains unknown if corin has a role in regulating adipose tissue function. Here, we examined adipose tissue morphology and function in corin knockout (KO) mice. We observed increased weights and cell sizes in white adipose tissue (WAT), decreased levels of uncoupling protein 1 (Ucp1), a brown adipocyte marker in WAT and brown adipose tissue (BAT), and suppressed thermogenic gene expression in BAT from corin KO mice. At regular room temperature, corin KO and wild-type mice had similar metabolic rates. Upon cold exposure at 4 °C, corin KO mice exhibited impaired thermogenic responses and developed hypothermia. In BAT from corin KO mice, the signaling pathway of p38 mitogen-activated protein kinase, peroxisome proliferator-activated receptor c coactivator 1a, and Ucp1 was impaired. In cell culture, ANP treatment increased Ucp1 expression in BAT-derived adipocytes from corin KO mice. These data indicate that corin mediated-ANP activation is an important hormonal mechanism in regulating adipose tissue function and body temperature upon cold exposure in mice.
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Cirillo, Chiara. "'Corti' or 'la Corti'? Definite article + surnames for women." Italianist 18, no. 1 (June 1998): 272–88. http://dx.doi.org/10.1179/ita.1998.18.1.272.
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Langenickel, Thomas H., Ines Pagel, Jens Buttgereit, Katja Tenner, Maren Lindner, Rainer Dietz, Roland Willenbrock, and Michael Bader. "Rat corin gene: molecular cloning and reduced expression in experimental heart failure." American Journal of Physiology-Heart and Circulatory Physiology 287, no. 4 (October 2004): H1516—H1521. http://dx.doi.org/10.1152/ajpheart.00947.2003.
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Stored cardiac pro-atrial natriuretic peptide (pro-ANP) is converted to ANP and released upon stretch from the atria into the circulation. Corin is a serin protease with pro-ANP-converting properties and may be the rate-limiting enzyme in ANP release. This study was aimed to clone and sequence corin in the rat and to analyze corin mRNA expression in heart failure when ANP release upon stretch is blunted. Full-length cDNA of rat corin was obtained from atrial RNA by RT-PCR and sequenced. Tissue distribution as well as regulation of corin mRNA expression in the atria were determined by RT-PCR and RNase protection assay. Heart failure was induced by an infrarenal aortocaval shunt. Stretch was applied to the left atrium in a working heart modus, and ANP was measured in the perfusates. The sequence of rat corin cDNA was found to be 93.6% homologous to mouse corin cDNA. Corin mRNA was expressed almost exclusively in the heart with highest concentrations in both atria. The aortocaval shunt led to cardiac hypertrophy and heart failure. Stretch-induced ANP release was blunted in shunt animals (control 1,195 ± 197 fmol·min−1·g−1; shunt: 639 ± 99 fmol·min−1·g−1, P < 0.05). Corin mRNA expression was decreased in both atria in shunt animals [right atrium: control 0.638 ± 0.004 arbitrary units (AU), shunt 0.566 ± 0.014 AU, P < 0.001; left atrium: control 0.564 ± 0.009 AU, shunt 0.464 ± 0.009 AU, P < 0.001]. Downregulation of atrial corin mRNA expression may be a novel mechanism for the blunted ANP release in heart failure.
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Chen, Shenghan, Subha Sen, David Young, Wei Wang, Christine S. Moravec, and Qingyu Wu. "Protease corin expression and activity in failing hearts." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 5 (November 2010): H1687—H1692. http://dx.doi.org/10.1152/ajpheart.00399.2010.
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Atrial and brain natriuretic peptides (ANP and BNP) regulate blood pressure and cardiac function. In patients with heart failure (HF), plasma levels of pro-ANP and pro-BNP, the precursor forms of ANP and BNP, are highly elevated, but the mechanism underlying the apparent deficiency in natriuretic peptide processing is unclear. Corin is a cardiac protease that activates natriuretic peptides. In this study, we examined corin protein expression and activity in mouse and human failing hearts. Tissue samples were obtained from a mouse model of HF induced by myotrophin overexpression and from human nonfailing, hypertrophic, and failing hearts. Corin protein levels in the membrane fraction and tissue lysate were measured by Western blotting and ELISA. Corin catalytic and biological activities were measured by fluorescent substrate and pro-ANP processing assays. In mice, corin protein levels did not change with age in normal hearts but increased significantly in failing hearts. In humans, corin protein levels were similar in the atrium from nonfailing and failing hearts but were increased in the ventricle in failing hearts compared with those in nonfailing or hypertrophic hearts. Unlike the protein level, however, corin activity did not increase in failing hearts, as measured by fluorogenic substrate and pro-ANP processing assays. Our results indicate that corin activation is a rate-limiting step in failing hearts. Insufficient corin activation is expected to prevent natriuretic peptide processing and may contribute to body fluid retention and impaired cardiac function in patients with HF.
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Zhang, Xianrui, Xiabing Gu, Yikai Zhang, Ningzheng Dong, and Qingyu Wu. "Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure." Biology 11, no. 5 (May 7, 2022): 717. http://dx.doi.org/10.3390/biology11050717.
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Atrial natriuretic peptide (ANP) is a crucial element of the cardiac endocrine function that promotes natriuresis, diuresis, and vasodilation, thereby protecting normal blood pressure and cardiac function. Corin is a type II transmembrane serine protease that is highly expressed in the heart, where it converts the ANP precursor to mature ANP. Corin deficiency prevents ANP activation and causes hypertension and heart disease. In addition to the heart, corin is expressed in other tissues, including those of the kidney, skin, and uterus, where corin-mediated ANP production and signaling act locally to promote sodium excretion and vascular remodeling. These results indicate that corin and ANP function in many tissues via endocrine and autocrine mechanisms. In heart failure patients, impaired natriuretic peptide processing is a common pathological mechanism that contributes to sodium and body fluid retention. In this review, we discuss most recent findings regarding the role of corin in non-cardiac tissues, including the kidney and skin, in regulating sodium homeostasis and body fluid excretion. Moreover, we describe the molecular mechanisms underlying corin and ANP function in supporting orderly cellular events in uterine spiral artery remodeling. Finally, we assess the potential of corin-based approaches to enhance natriuretic peptide production and activity as a treatment of heart failure.
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Hu, Xinyi, Ming Su, Jun Lin, Lei Zhang, Wen Sun, Jian Zhang, Ye Tian, and Wei Qiu. "Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation." Disease Markers 2019 (January 14, 2019): 1–8. http://dx.doi.org/10.1155/2019/9429323.
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Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays. We identified Corin as one of the most significantly downregulated genes among 2218 differentially expressed genes (≥2-fold, P<0.05). By using a real-time qPCR assay, we observed that the expression of renal Corin in IR-injured mice was reduced to 11.5% of the sham-operated mice and that the protein level of renal Corin in IR-injured mice was also downregulated. Interestingly, renal IR injury in mice induced the downregulation of Corin in heart tissues, suggesting that the overall synthesis of Corin may be suppressed. We recruited 11 recipients complicated with DGF and 16 without DGF, and plasma Corin concentrations were determined by ELISA. We observed that the plasma Corin levels were indeed reduced in recipients complicated with DGF (0.98 vs. 1.95 ng/ml, P<0.05). These findings demonstrate that Corin may be a potential biomarker of DGF after kidney transplantation and may participate in the regulation of renal IR injury.
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He, Meiling, Tiantian Zhou, Yayan Niu, Wansheng Feng, Xiabing Gu, Wenting Xu, Shengnan Zhang, et al. "The protease corin regulates electrolyte homeostasis in eccrine sweat glands." PLOS Biology 19, no. 2 (February 16, 2021): e3001090. http://dx.doi.org/10.1371/journal.pbio.3001090.
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Sweating is a basic skin function in body temperature control. In sweat glands, salt excretion and reabsorption are regulated to avoid electrolyte imbalance. To date, the mechanism underlying such regulation is not fully understood. Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), a cardiac hormone essential for normal blood volume and pressure. Here, we report an unexpected role of corin in sweat glands to promote sweat and salt excretion in regulating electrolyte homeostasis. In human and mouse eccrine sweat glands, corin and ANP are expressed in the luminal epithelial cells. In corin-deficient mice on normal- and high-salt diets, sweat and salt excretion is reduced. This phenotype is associated with enhanced epithelial sodium channel (ENaC) activity that mediates Na+ and water reabsorption. Treatment of amiloride, an ENaC inhibitor, normalizes sweat and salt excretion in corin-deficient mice. Moreover, treatment of aldosterone decreases sweat and salt excretion in wild-type (WT), but not corin-deficient, mice. These results reveal an important regulatory function of corin in eccrine sweat glands to promote sweat and salt excretion.
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Bonier, Frances, Ignacio T. Moore, and Raleigh J. Robertson. "The stress of parenthood? Increased glucocorticoids in birds with experimentally enlarged broods." Biology Letters 7, no. 6 (June 2011): 944–46. http://dx.doi.org/10.1098/rsbl.2011.0391.
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Variation in baseline glucocorticoid (cort) levels can be attributed, at least in part, to differences in energetic demands confronting individuals. Elevated baseline cort levels are routinely interpreted as indicating individuals in poor condition, with low relative fitness. However, when greater reproductive effort increases energetic demands, individuals with high cort might paradoxically be those with the highest fitness. Here, we experimentally test the hypothesis that increased reproductive demand causes increases in baseline cort (the Cort-Adaptation hypothesis). We measured maternal baseline cort before and after experimentally enlarging and reducing brood sizes in tree swallows ( Tachycineta bicolor ). Females with experimentally enlarged broods had greater increases in baseline cort and fledged more offspring than females with reduced broods. Additionally, females with greater increases in baseline cort had higher offspring-provisioning rates than females with lower changes in cort. These findings demonstrate that increased reproductive demand can cause increased baseline cort. As yet, we do not know if these increases in cort cause increased allocation of resources towards reproduction, but the positive relationship between parental behaviour and cort suggests that increased cort does not always interfere with reproductive investment, and might instead facilitate it.
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Valio, Adriana. "Starspots properties and stellar activity from planetary transits." Proceedings of the International Astronomical Union 12, S328 (October 2016): 69–76. http://dx.doi.org/10.1017/s1743921317004094.
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AbstractMagnetic activity of stars manifests itself in the form of dark spots on the stellar surface. This in turn will cause variations of a few percent in the star light curve as it rotates. When an orbiting planet eclipses its host a star, it may cross in front of one of these spots. In this case, a “bump” will be detected in the transit lightcurve. By fitting these spot signatures with a model, it is possible to determine the spots physical properties such as size, temperature, location, magnetic field, and lifetime. Moreover, the monitoring of the spots longitude provides estimates of the stellar rotation and differential rotation. For long time series of transits during multiple years, magnetic cycles can also be determined. This model has been applied successfully to CoRoT-2, CoRoT-4, CoRot-5, CoRoT-6, CoRoT-8, CoRoT-18, Kepler-17, and Kepler-63.
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Sullivan, Ryan D., Aiilyan K. Houng, Inna P. Gladysheva, Tai-Hwang M. Fan, Ranjana Tripathi, Guy L. Reed, and Dong Wang. "Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death." International Journal of Molecular Sciences 21, no. 10 (May 14, 2020): 3456. http://dx.doi.org/10.3390/ijms21103456.
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Altered expression of corin, a cardiac transmembrane serine protease, has been linked to dilated and ischemic cardiomyopathy. However, the potential role of corin in myocardial infarction (MI) is lacking. This study examined the outcomes of MI in wild-type vs. cardiac-specific overexpressed corin transgenic (Corin-Tg) mice during pre-MI, early phase (3, 24, 72 h), and late phase (1, 4 weeks) post-MI. Corin overexpression significantly reduced cardiac cell apoptosis (p < 0.001), infarct size (p < 0.001), and inhibited cleavage of procaspases 3, 9, and 8 (p < 0.05 to p < 0.01), as well as altered the expression of Bcl2 family proteins, Bcl-xl, Bcl2 and Bak (p < 0.05 to p < 0.001) at 24 h post-MI. Overexpressed cardiac corin also significantly modulated heart function (ejection fraction, p < 0.0001), lung congestion (lung weight to body weight ratio, p < 0.0001), and systemic extracellular water (edema, p < 0.05) during late phase post-MI. Overall, cardiac corin overexpression significantly reduced apoptosis, infarct size, and modulated cardiac expression of key members of the apoptotic pathway in early phase post-MI; and led to significant improvement in heart function and reduced congestion in late phase post-MI. These findings suggest that corin may be a useful target to protect the heart from ischemic injury and subsequent post-infarction remodeling.
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Henderson, L. J., N. P. Evans, B. J. Heidinger, K. A. Herborn, and K. E. Arnold. "Do glucocorticoids predict fitness? Linking environmental conditions, corticosterone and reproductive success in the blue tit, Cyanistes caeruleus." Royal Society Open Science 4, no. 10 (October 2017): 170875. http://dx.doi.org/10.1098/rsos.170875.
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Glucocorticoids, including corticosterone (CORT), have been suggested to provide a physiological link between ecological conditions and fitness. Specifically, CORT, which is elevated in response to harsh conditions, is predicted to be correlated with reduced fitness. Yet, empirical studies show that CORT can be non-significantly, positively and negatively linked with fitness. Divergent environmental conditions between years or study systems may influence whether CORT is linked to fitness. To test this, we monitored free-living blue tits ( Cyanistes caeruleus ) during breeding over 3 years. We quantified foraging conditions during brood rearing, and examined whether they were correlated with parental baseline CORT and reproductive success. We then tested whether CORT predicted fitness. Elevated parental CORT was associated with lower temperatures, greater rainfall and lower territory-scale oak density. Whereas asynchrony with the caterpillar food peak was correlated with reduced nestling mass and fledging success, but not parental CORT. Only low temperatures were associated with both reduced nestling mass and elevated parental CORT. Despite this, parents with elevated CORT had lighter offspring in all years. Contrarily, in 2009 parental CORT was positively correlated with the number fledged. The absence of a direct link between the foraging conditions that reduce nestling quality and elevate parental CORT suggests that parental CORT may provide a holistic measure of conditions where parents are working harder to meet the demands of developing young. As the positive correlation between parental CORT and fledging success differed between years, this suggests that contrasting conditions between years can influence correlations between parental CORT and fitness. Ultimately, as CORT concentrations are intrinsically variable and linked to the prevalent conditions, studies that incorporate environmental harshness will improve our understanding of evolutionary endocrinology.
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Hellemans, Alexander. "Dangling a COROT." Scientific American 297, no. 3 (September 2007): 32. http://dx.doi.org/10.1038/scientificamerican0907-32.
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Deleuil, Magali, Pascal Bordé, and Claire Moutou. "CoRoT mission highlights." Proceedings of the International Astronomical Union 6, S276 (October 2010): 44–49. http://dx.doi.org/10.1017/s1743921311019910.
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AbstractThe CoRoT space telescope is detecting planets with the transit method for more than four years. Its tally includes hot jupiter planets with orbital periods up to 95 days but also the first Super-Earth, CoRoT-7b, whose density is similar to the Earth's one, as well as close-in brown dwarfs. We review the status of the CoRoT/Exoplanet program, including some elements of the multi step strategy of complementary observations. We then present some of the CoRoT exoplanetary systems and how they widen the range of properties of the close-in low mass population and contribute to our understanding of the properties of planets.
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Maayoufi, Sadjida, Fairouz Hamouda, and Sofiane Djebien. "Organe de Corti." Morphologie 101, no. 335 (December 2017): 250–51. http://dx.doi.org/10.1016/j.morpho.2017.07.028.
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Vauclair, Gérard, Claude Catala, Annie Baglin, Michel Auvergne, and Eric Michel. "Asteroseismology with COROT." International Astronomical Union Colloquium 193 (2004): 553–59. http://dx.doi.org/10.1017/s0252921100011325.
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AbstractThe COROT project has been developed in the framework of the CNES small satellite programme, with European and Brazilian cooperation. It will be launched in 2006. It is dedicated to seismology and detection of telluric planets. It will perform relative broad-band photometry in visible light during very long (150 d) observing runs in the same direction, plus a number of short (10-20 d) observing runs. Both programmes will work simultaneously on the same region of the sky. The seismology programme aims to map the HR diagram and study in detail approximately 50 targets brighter than magnitude 9. The exoplanet programme will search for telluric planets slightly larger than the Earth orbiting around stars of magnitude 12 to 16, located in the habitable zone and closer. The data collected will also allow valuable seismic studies. A number of additional scientific programmes will also be conducted. The mission characteristics derived from the scientific objectives, the instrument and its performances for seismology, as well as preliminary observing plans, are presented.
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Gervens, Th, R. Krohn-Huppertz, and W. Schlagner. "CORIS®: Korrosionsdatenbank." Materials and Corrosion/Werkstoffe und Korrosion 44, no. 10 (October 1993): 402–9. http://dx.doi.org/10.1002/maco.19930441004.
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Fajrin, Rati Amanda, Murahartawaty Murahartawaty, and Soni Fajar S. Gumilang. "Perancangan Tata Kelola Teknologi Informasi di BAPAPSI Pemkab Bandung Menggunakan framework COBIT 5 Pada Domain EDM dan DSS." Journal of Information Systems Engineering and Business Intelligence 2, no. 2 (October 29, 2016): 74. http://dx.doi.org/10.20473/jisebi.2.2.74-80.
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Abstrak— Teknologi informasi memiliki peranan penting untuk mendukung pelaksanaan informasi publik. Pemerintah Kabupaten Bandung memiliki salah satu badan, yaitu BAPAPSI. Permasalahan yang ada di BAPAPSI, terutama pada bidang PPI adalah tidak meratanya jaringan internet di seluruh kecamatan, jaringan internet yang buruk, penanganan insiden yang buruk dan pengadaan server yang tidak mendukung penggunaan aplikasi di BAPAPSI. Oleh karena itu, untuk menyelesaikan masalah yang ada di lingkungan BAPAPSI menggunakan metodologi 7 lifecycle COBIT 5. COBIT 5 menyediakan panduan yang lengkap, pedoman yang komprehensif dalam membantu organisasi untuk mencapai efektivitas penggunaan TI. Tahap pertama pada penelitian ini adalah melakukan penilaian tingkat kapabilitas, kemudian memetakan governance objective, enterprise goals, IT Related Goals dan IT Process pada COBIT 5. Sehingga menghasilkan proses prioritas yaitu EDM04 dan DSS01 yang akan dianalisis dan dilakukan perancangan prosedur tata kelola TI dengan menggunakan COBIT 5. Pada penelitian ini juga merekomendasikan struktur organisasi sasaran sesuai dengan kebutuhan Pemerintah Kabupaten Bandung.Kata Kunci— tata kelola TI, COBIT 5, domain EDM, domain DSS, PemerintahanAbstract— Information technology has an important role to support the implementation of public information. Bandung regency government has one of the bodies, named BAPAPSI. The existing problems in BAPAPSI, especially in PPI are uneven internet network in all districts, bad internet connection, bad handling of the incident, and the procurement of servers that do not support the use of the application in BAPAPSI. Therefore, 7 lifecycle COBIT 5 methodology is used to solve the problems in BAPAPSI. COBIT 5 provides complete, comprehensive guidelines in helping organizations to achieve the effective use of IT. The first stage in this research is assess capability level, then the next stage are mapping governance objective, enterprise goals, IT Related Goals and IT Process on COBIT 5. So, the results are the priority process on EDM04 and DSS01 domain to be analyzed and to design procedure IT governance using COBIT 5. This research also recommends the target of organizational structure in accordance with the needs of the Bandung regency government.Keywords— IT Governance, COBIT 5, EDM domain, DSS domain, Government
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Bechtold, Andrea G., and Deborah A. Scheuer. "Glucocorticoids act in the dorsal hindbrain to modulate baroreflex control of heart rate." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 4 (April 2006): R1003—R1011. http://dx.doi.org/10.1152/ajpregu.00345.2005.
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Systemic corticosterone (Cort) modulates arterial baroreflex control of both heart rate and renal sympathetic nerve activity. Because baroreceptor afferents terminate in the dorsal hindbrain (DHB), an area with dense corticosteroid receptor expression, we tested the hypothesis that prolonged activation of DHB Cort receptors increases the midpoint and reduces the gain of arterial baroreflex control of heart rate in conscious rats. Small (3–4 mg) pellets of Cort (DHB Cort) or Silastic (DHB Sham) were placed on the surface of the DHB, or Cort was administered systemically by placing a Cort pellet on the surface of the dura (Dura Cort). Baroreflex control of heart rate was determined in conscious male Sprague Dawley rats on each of 4 days after initiation of treatment. Plots of arterial pressure vs. heart rate were analyzed using a four-parameter logistic function. After 3 days of treatment, the arterial pressure midpoint for baroreflex control of heart rate was increased in DHB Cort rats (123 ± 2 mmHg) relative to both DHB Sham (108 ± 3 mmHg) and Dura Cort rats (109 ± 2 mmHg, P < 0.05). On day 4, baseline arterial pressure was greater in DHB Cort (112 ± 2 mmHg) compared with DHB Sham (105 ± 2 mmHg) and Dura Cort animals (106 ± 2 mmHg, P < 0.05), and the arterial pressure midpoint was significantly greater than mean arterial pressure in the DHB Cort group only. Also on day 4, maximum baroreflex gain was reduced in DHB Cort (2.72 ± 0.12 beats·min−1·mmHg−1) relative to DHB Sham and Dura Cort rats (3.51 ± 0.28 and 3.37 ± 0.27 beats·min−1·mmHg−1, P < 0.05). We conclude that Cort acts in the DHB to increase the midpoint and reduce the gain of the heart rate baroreflex function.
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Wang, Jing. "Application of DNA Molecular Identification Method to Distinguish Ejiao and its Adulterants." Journal of Advances in Medicine Science 4, no. 2 (August 19, 2021): 1. http://dx.doi.org/10.30564/jams.v4i2.2952.
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To identify Ejiao and its adulterants at the DNA level by using DNA molecula marker. Ejiao (Asini Corii Colla) is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the morphological characteristics of Asini Corii Colla and its adulterants, traditional identification techniques often complex and professional, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distinction between Asini Corii Colla and its adulterants accurately, this study identified and its adulterant samples based on the CytB sequence. Sequence characteristics, Basic Local Alignment Search Tool (BLAST) application, genetic distance, construction of phylogenetic tree showed the CytB sequence to accurately identify Asini Corii Colla from its adulterants. Furthermore, in this study, we designed a specific primer, based on the CytB sequence, and established a PCR detection system for rapid, sensitive, and specific identification of Asini Corii Colla. Compared to DNA barcoding technology, this method has shorter detection time, stronger specificity, and higher sensitivity, which lays the foundation for the rapid identification of Asini Corii Colla.
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Haywood, R. D., A. C. Cameron, D. Queloz, S. C. C. Barros, M. Deleuil, R. Fares, M. Gillon, et al. "Planets and Stellar Activity: Hide and Seek in the CoRoT-7 system." Proceedings of the International Astronomical Union 8, S299 (June 2013): 237–40. http://dx.doi.org/10.1017/s1743921313008478.
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AbstractSince the discovery of the transiting Super-Earth CoRoT-7b, several investigations have been made of the number and precise masses of planets present in the system, but they all yield different results, owing to the star's high level of activity. Radial velocity (RV) variations induced by stellar activity therefore need to be modelled and removed to allow a reliable detection of all planets in the system. We re-observed CoRoT-7 in January 2012 with both HARPS and the CoRoT satellite, so that we now have the benefit of simultaneous RV and photometric data. We fitted the off-transit variations in the CoRoT lightcurve using a harmonic decomposition similar to that implemented in Queloz et al. (2009). This fit was then used to model the stellar RV contribution, according to the methods described by Aigrain et al. (2011). This model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b and CoRoT-7c. We also assess the evidence for the presence of one or two additional planetary companions.
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Rensel, M. A., D. Comito, S. Kosarussavadi, and B. A. Schlinger. "Region-Specific Neural Corticosterone Patterns Differ From Plasma in a Male Songbird." Endocrinology 155, no. 9 (September 1, 2014): 3572–81. http://dx.doi.org/10.1210/en.2014-1231.
Full textAbstract:
Abstract The adrenal hormone corticosterone (CORT) acts on brain to mediate physiology and behavior. In songbirds, behavioral effects of CORT vary across species, environmental conditions, and life history stage, with several mechanisms proposed to account for these divergent results. Although blood CORT levels are well characterized, few studies measure CORT within the brain itself. Here we used in vivo microdialysis to measure CORT in two regions of the zebra finch brain, the hippocampus (HP) and caudal nidopallium (cNp). Our results show that we can successfully measure physiological levels of CORT in brain within 15- to 30-minute intervals of dialysate collection. Moreover, we found that levels in the cNp were generally lower than levels in the HP. Surprisingly, whereas plasma CORT levels increased in response to a standard stressor, no stress-induced surge was detected in the HP or cNp. In addition, although a diel CORT rhythm was observed in plasma, the rhythm in brain was attenuated and only observed when levels were integrated over a 4-hour time period. Regional differences in brain CORT levels were reflected in local mRNA expression levels of the CORT-inactivating enzyme 11β-hydroxysteroid dehydrogenase type 2 with levels elevated in the cNp relative to the HP. Region-specific CORT metabolism may therefore play a role in buffering the brain from CORT fluctuations.
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Chernin, J., Diane J. McLaren, A. Morinan, and B. N. Jamieson. "Mesocestoides corti: parameters of infection in CBA/Ca mice and the effect of introducing a concomitant trematode infection." Parasitology 97, no. 3 (December 1988): 393–402. http://dx.doi.org/10.1017/s0031182000058819.
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SummaryCBA/Ca mice infected with the tetrathyridia of Mesocestoides corti were exposed to Schistosoma mansoni cercariae either simultaneously, or at varying intervals after the initial M. corti infection. Cohorts were infected with either parasite alone. The dual infected mice and the mice harbouring M. corti alone were significantly heavier than either naive controls or mice carrying the S. mansoni infection only. The livers and spleens from dual infection mice were also found to be significantly heavier than those from other groups. Free M. corti tetrathyridia were reduced in number in the peritoneal cavity of dual infected mice, as compared with mice harbouring a single infection. Furthermore, the intensity of the initial M. corti infection, as measured by the number of capsules surrounding parasites in the liver, was reduced when the mice experienced an S. mansoni infection 21 days later. The mice which were exposed to M. corti only exhibited more mast cells and eosinophils around encapsulated tetrathyridia in the liver than did dual infection mice, while cells surrounding S. mansoni egg granulomas in the liver were significantly increased in dual infection mice. An increase in serum alkaline phosphatase levels was detected in both the mice receiving the dual infection and the mice with the S. mansoni only infection, but not in mice harbouring M. corti alone.
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Cordoba-Chacón, José, Manuel D. Gahete, Ana I. Pozo-Salas, Luis de Lecea, Justo P. Castaño, and Raúl M. Luque. "Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice." Endocrinology 157, no. 7 (May 13, 2016): 2810–23. http://dx.doi.org/10.1210/en.2016-1195.
Full textAbstract:
Cortistatin (CORT) shares high structural and functional similarities with somatostatin (SST) but displays unique sex-dependent pituitary actions. Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression/secretion, Proopiomelanocortin expression, and circulating ACTH/corticosterone/ghrelin levels, male CORT-KO mice only display increased plasma GH/corticosterone levels. Changes in peripheral ghrelin and SST (rather than hypothalamic levels) seem to regulate GH/ACTH axes in CORT-KOs under fed conditions. Because changes in GH/ACTH axes during fasting provide important adaptive mechanisms, we sought to determine whether CORT absence influences GH/ACTH axes during fasting. Accordingly, fed and fasted male/female CORT-KO were compared with littermate controls. Fasting increased circulating GH levels in male/female controls but not in CORT-KO, suggesting that CORT can be a relevant regulator of GH secretion during fasting. However, GH levels were already higher in CORT-KO than in controls in fed state, which might preclude a further elevation in GH levels. Interestingly, although fasting-induced pituitary GH expression was elevated in both male/female controls, GH expression only increased in fasted female CORT-KOs, likely owing to specific changes observed in key factors controlling somatotrope responsiveness (ie, circulating ghrelin and IGF-1, and pituitary GHRH and ghrelin receptor expression). Fasting increased corticosterone levels in control and, most prominently, in CORT-KO mice, which might be associated with a desensitization to SST signaling and to an augmentation in CRH and ghrelin-signaling regulating corticotrope function. Altogether, these results provide compelling evidence that CORT plays a key, sex-dependent role in the regulation of the GH/ACTH axes in response to fasting.