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Kumar, M. Vijaya, H. Rama Subba Reddy, A. Narayana Swamy, K. Jayappa, M. Sreekanth Reddy, D. Veera Nagenddra Kumar, and V. Uday Kiran. "A Therapeutic Evaluation of Anticancer and Pharmacological Abilities on Tinospora cordifolia: A Systematic Review." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 13 (June 3, 2024): 1–8. http://dx.doi.org/10.56557/upjoz/2024/v45i134130.
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Tinospora cordifolia (Tc), commonly called as Giloy, it is a herbaceous vine that is widely used in traditional medicine systems for its alleged anti-cancer effects. The purpose of this systematic study is to assess Tinospora cordifolia’s (Tc) medicinal potential against cancer. A thorough search of various scientific databases was done for studies looking at Tinospora cordifolia's anti-cancer properties. The findings demonstrate a varied variety of In vitro and In vivo research demonstrating Tinospora cordifolia’s (Tc) anti-proliferative, apoptotic and anti-metastatic activities against many cancer types, including breast, prostate, colon, and leukaemia. Mechanistic insights into its mode of action, such as modulation of signaling pathways involved in cell cycle regulation, apoptosis and angiogenesis, are presented. However, limitations in study designs, inconsistency in methodology, and differences in reported outcomes highlight the need for more well-designed clinical trials to evaluate Tinospora cordifolia's efficacy and safety as a potential supplementary medicine in cancer treatment regimens. Therapeutic plants, such as T. cordifolia, can strengthen the body's defences against disease and cure specific areas, displaying more body compatibility and fewer side effects than medications. In conjunction with this, the current study highlights T. cordifolia's pharmacological potential against a variety of illnesses.
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Catalano, S., A. Bilia, G. Flamini, L. Pistelli, and V. De Feo. "Cordifoliol: A New Iridoid fromMentzelia cordifolia." Planta Medica 58, S 1 (December 1992): 717. http://dx.doi.org/10.1055/s-2006-961747.
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Shakil, Najam A., and Dinesh B. Saxena. "Isolation and Structure of Cordifolin, A Novel Insecticidal Oxygenated Chalcone, from the Stem of Tinospora Cordifolia Miers." Natural Product Communications 1, no. 7 (July 2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100707.
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Cordifolin, a chalcone reported for the first time from a natural source, has been isolated from the ethanolic extract of the woody stem of Giloe (Tinospora cordifolia). The chemical structure was established as 1-(2′,3′,4′-trihydroxyphenyl)-3-(4′‘-methoxyphenyl)-propen-1-one by spectroscopic analysis. The compound exhibited good insect growth regulatory activity against larvae of Spodoptera litura.
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Marina Silalahi. "Utilization and bioactivity of Anredera cordifolia (Ten.) Steenis." GSC Biological and Pharmaceutical Sciences 26, no. 2 (February 28, 2024): 128–34. http://dx.doi.org/10.30574/gscbps.2024.26.2.0020.
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Anredera cordifolia (Ten.) Steenis is a multifunctional plant have been used decoration, food and traditional medicine. This study aims to explain the botany and use of A. cordifolia as a traditional medicinal plant and its bioactivity. The method used in this study is library research online using the keywords such as: A. cordifolia, uses of A. cordifolia and bioactivity of A. cordifolia. The all of information are synthesized so that explain of botanicals, benefits and bioactivity. The A. cordifolia has activity as cure of wound, anti-bacterial, anti-cholesterol and obesity, postpartum, anti-diabetes mellitus, antioxidant and anti-inflammatory, anti-hypertensive, anti-cancer, and lowering uric acid. The A. cordifolia contains triterpenoid saponins, steroids, saponins, glycosides, flavonoids, saponins and alkaloids, ursolic acid, ancordin, and apigenin. Saponins have been used to treat diabetes, liver, hepatitis, cardiovascular hypertension, hyper-cholesterol, and physical stress. Utilization of A. cordifolia as an anti-microbial has the potential to be used as a food preservative as well as providing healthful effects.
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Noviyanty, Yuska, Harlina Harlina, and Ayu Yulianti Adha. "PENGARUH METODE EKSTRAKSI TERHADAP KADAR FLAVONOID EKSTRAK ETANOL DAUN BINAHONG(Anredera Cordifolia (Ten.)) DENGAN METODE SPEKTROFOTOMETRI UV-VIS." Oceana Biomedicina Journal 5, no. 2 (July 29, 2022): 93–106. http://dx.doi.org/10.30649/obj.v5i2.80.
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ABSTRAK
Daun binahong (Anredera cordifolia(Ten)) adalah salah satu tanaman yang secara empiris,dan mengandung banyak senyawa metabolit sekunder salah satunya senyawa flavonoid. Penelitian ini bertujuan untuk melihat adanya pengaruh ekstrak etanol daun binahong (Anredera cordifolia(Ten.)) dengan menggunakan metode ekstraksi maserasi dan soxhletasi serta akan membandingkan hasil identifikasi dan penetapan kadar dari ekstraksi daun binahong (Anredera cordifolia(Ten.)) dengan menggunakan metode spektrofotometri Uv-Vis.
Proses ekstraksi dengan cara maserasi dan soxhletasi dilakukan untuk mendapatkan ekstrak daun binahong (Anredera cordifolia(Ten.)). Kemudian dilakukan identifikasi senyawa flavonoid dengan penambahan serbuk Mg dan HCl dimana positif flavonoid jika berwarna kuning-orange. Penetapan kadar senyawa flavonoid dari ekstrak daun binahong (Anredera cordifolia(Ten)) dengan metode spektrofotometri UV-Vis.
Hasil penelitian menujukkan bahwa ekstrak daun binahong (Anredera cordifolia(Ten)) metode maserasi dan soxhletasi positif mengandung flavonoid, dilihat dari warna yang dihasilkan yaitu orange. Serta didapatkan kadar flavonoid ekstrak etanol daun binahong (Anredera cordifolia(Ten)) metode maserasi adalah 2,43 %. Sedangkan kadar flavonoid ekstrak etanol daun binahong (Anredera cordifolia(Ten)) metode soxhletasi adalah 1,76%
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XIE, YIFEI, LEI XIE, and ZHIXINAG ZHANG. "A new species and a revised of Sloanea cordifolia (Elaeocarpaceae) in China, southeast Yunnan." Phytotaxa 346, no. 2 (April 4, 2018): 189. http://dx.doi.org/10.11646/phytotaxa.346.2.6.
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The taxonomic status of Sloanea cordifolia has been questionable as a variation of S. tomentosa by Coode. After field investigations, careful examination of herbarium specimens, the results showed that the flower of S. cordifolia is similar to S. tomentosa, and the difference between these two species is hair-related only. The statistical analysis revealed S. cordifolia and S. tomentosa clearly belong to the category of short prickles compared to species throughout the area; prick length of S. longiaculeatae is shorter compared to S. mollis, but the discontinuity is not particularly obvious; the width showed S. longiaculeatae is different from S. mollis, and S. cordifolia is larger than S. tomentosa. It is also the first time that the description of Sloanea cordifolia was completed. S. cordifolia K. M. Feng ex Hung T. Chang treated as Sloanea tomentosa (Benth.) Rehder & E.H. Wilson var. cordifolia (K. M. Feng ex Hung T. Chang) Y. F. Xie & Z. X. Zhang. The new species Sloanea longiaculeatae have been described and illustrated.
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Garg, Praveen, and Rajesh Garg. "QUALITATIVE AND QUANTITATIVE ANALYSIS OF LEAVES AND STEM OF TINOSPORA CORDIFOLIA IN DIFFERENT SOLVENT EXTRACT." Journal of Drug Delivery and Therapeutics 8, no. 5-s (October 1, 2018): 259–64. http://dx.doi.org/10.22270/jddt.v8i5-s.1967.
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Tinospora cordifolia is known as Giloe and Guduchi, with significant importance in the traditional medicinal systems. It is dioeciously plant. It is mostly used in Ayurved system. It is also known as a ‘Rasayans’ of medicinal system, which develops immune system of the body and protect against infection. The aim of this study is carried out to analyse the phytochemical compounds in leaves and stem extracts of T. cordifolia by using phytochemical screening tests and estimate total flavonoid content (TFC) by using aluminium chloride method in the sample extracts. The leaf and stem extracts of T. cordifolia expressed the presence of several phytochemicals viz., flavonoids, amino acids, diterpines, protein, saponins and carbohydrates. The result of phytochemical screening tests revealed that diterpines and carbohydrates are positive in all extracts of T. cordifolia, but flavonoids and saponins only present in methanol and ethanol extracts. TFC of T. cordifolia was higher in ethanolic leaves extracts than mathanolic leaves extracts. The studies justify that T. cordifolia use in traditional medicines. The investigation further proposed that the phytochemicals present in stems and leaves of T. cordifolia, which can be use as natural antioxidants in medicinal drugs.
Keywords: Tinospora cordifolia, Phytochemicals, Flavonoids
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Bana, Sweeti, Nitin Kumar, Ali Sartaj, Abdulsalam Alhalmi, Ashraf Ahmed Qurtam, Fahd A. Nasr, Mohammed Al-Zharani, et al. "Rubia cordifolia L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats." Pharmaceuticals 16, no. 11 (November 9, 2023): 1586. http://dx.doi.org/10.3390/ph16111586.
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Background: Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects of the roots of Rubia cordifolia L. (R. cordifolia L.) in the Wistar rat model for diabetic neuropathy and possible neuroprotective, antidiabetic, and analgesic mechanisms underlying this effect. Materials and Methods: Rats were divided into five experimental groups. An amount of 0.25% carboxy methyl cellulose (CMC) in saline and streptozotocin (STZ) (60 mg/kg) was given to group 1 and group 2, respectively. Group 3 was treated with STZ and glibenclamide simultaneously while groups 4 and 5 were simultaneously treated with STZ and hydroalcoholic extract of the root of R. cordifolia, respectively. Hot plate and cold allodynias were used to evaluate the pain threshold. The antioxidant effects of R. cordifolia were assessed by measuring Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). At the end of the study, sciatic nerve and brain tissues were collected for histopathological study. Bcl-2 proteins, cleaved caspase-3, and Bax were assessed through the Western blot method. Results: R. cordifolia significantly attenuated paw withdrawal and tail flick latency in diabetic neuropathic rats. R. cordifolia significantly (p < 0.01) improved the levels of oxidative stress. It was found to decrease blood glucose levels and to increase animal weight in R. cordifolia-treated groups. Treatment with R. cordifolia suppressed the cleaved caspase-3 and reduced the Bax:Bcl2 ratio in sciatic nerve and brain tissue compared to the diabetic group. Histopathological analysis also revealed a marked improvement in architecture and loss of axons in brain and sciatic nerve tissues at a higher dose of R. cordifolia (400 mg/kg). Conclusion: R. cordifolia attenuated diabetic neuropathy through its antidiabetic and analgesic properties by ameliorating apoptosis and oxidative stress.
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Tautua, BamidelBae Martin Amos, Imomotimi Timipa Ajoko, and Precious Ezougha Oyaseiye. "Phytochemical Screening and Antioxidant Potential of Methanol Extract of Triumfetta cordifolia A. Rich. (Malvaceae) Leaves." Scholars International Journal of Traditional and Complementary Medicine 7, no. 01 (January 8, 2024): 1–7. http://dx.doi.org/10.36348/sijtcm.2024.v07i01.001.
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Triumfetta cordifolia is a medicinal plant that has been widely utilized in Africa for its therapeutic properties in treating various ailments. The purpose of this research was to investigate phytochemicals and in vitro antioxidant activity of the leaf extract of T. cordifolia. Standard methods were employed to conduct qualitative phytochemical screening of the plant extract. This study used the DPPH (1, 1diphenyl-2-picryl hydrazyl) radical scavenging and ferric reducing antioxidant power method to assess antioxidant activity. Phytochemical analysis of T. cordifolia leaves indicated the existence of saponins, tannins, terpenoids, cardiac glycosides, alkaloids, flavonoids but no anthraquinones. In the DPPH scavenging test, the IC50 value of the methanolic extract was discovered to be 1.29 µg/mL, and the standard reference value for ascorbic acid was 2.14 µg/mL. The leaf extract of T. cordifolia displayed stronger inhibition of DPPH activity, showing a higher potency than ascorbic acid. The DPPH scavenging activity was also shown to increase with concentration. In FRAP assay, the T. cordifolia leaf extract and the ascorbic acid revealed reducing power of 71.01±0.15 and 548.39±1.62 μM Fe2+ per mg of extract, respectively. The FRAP assay demonstrated that ascorbic acid exhibited greater antioxidant activity than the leaf extract of T. cordifolia. The presence of flavonoids and phenols in T. cordifolia leaves may account for the observed antioxidant activity. In conclusion, the study's findings suggest that that T. cordifolia leaf extract could be a source of lead compounds with promising antioxidant activity.
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Dahanayake, JM, PK Perera, P. Galappatty, P. Fernando, and LDAM Arawwawala. "Tinospora cordifolia (Wild) Hook.f. (Thomas) grown in Sri Lanka: Pharmacognostical, physico- chemical and phytochemical analysis of the stem." Journal of Ayurvedic and Herbal Medicine 6, no. 4 (January 14, 2021): 217–21. http://dx.doi.org/10.31254/jahm.2020.6404.
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Tinospora cordifolia (wild) Hook.f. (Thomas) is an important medicinal plant distributed throughout in Sri Lanka and commonly known as Rasakinda in Sinhala and Giloy in English. It is widely used in Sri Lankan traditional medical system and Ayurveda for the treatment of diabetes mellitus, fever, arthritis, skin diseases and for Rasayana (rejuvenating) therapies due to its anti-inflammatory, hypoglyceamic, immunomodulatory, antioxident, anti-allergy, antipyretic, antiarthritic and various other medicinal properties. Imported T. cordifolia stems and Sri Lankan grown T. cordifolia stems can be found in Sri Lankan herbal market. Moreover, different varieties of Tinospora species known as Tikthakinda, Bukinda and Gatakinda are available in the market under the name of Rasakinda which leads to adulteration. Hence, in this research an attempt was made to develop standards for genuine T. cordifolia grown in Sri Lanka. Stems of T. cordifolia evaluated for macroscopical, microscopical, physico-chemical, phytochemical constituents, TLC and HPTLC fingerprint patterns. Microscopical examinations of T. cordifolia stem exhibited the wheel shaped appearance at the transverse cut surface, which is a main characteristic feature of the family Menespermaceae. Stem also showed the mucilage cells and abundant starch granules. Percentages of total ash, water soluble ash and acid insoluble ash, were 9.1%+0.1, 2.31%+0.1, <0.1% respectively. Among the percentages of extractable matter of T. cordifolia, highest amount was shown in hot water extract (16.2 %+0.3). Heavy metals (Hg, As, Cd, Pb) were within the limits given in WHO guidelines. Phytochemical screening revealed the presence of phenols, saponins, tannins, steroids, flavonoids, terpenoids and cardiac glycosides. TLC fingerprint of T. cordifolia was developed using butanol: ethyl acetate: acetic acid: water in a ratio of 5: 8: 6:2 v/v and compared with one of its marker compound, Berberine. The HPTLC fingerprint patt ern of T. cordifolia showed a spot bearing the same Rf value corresponds to Berberine, at wavelength 254 nm. In conclusion, the results obtained from this study can be used as a standard reference for Sri Lankan grown T. cordifolia stems.
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Bari, Ichsan Nurul, Hisashi Kato-Noguchi, Arihiro Iwasaki, and Kiyotake Suenaga. "Allelopathic Potency and an Active Substance from Anredera cordifolia (Tenore) Steenis." Plants 8, no. 5 (May 18, 2019): 134. http://dx.doi.org/10.3390/plants8050134.
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Anredera cordifolia (Tenore) Steenis is widely planted as an ornamental and medicinal plant in Indonesia. On the other hand, in some other countries this plant is classified as a noxious weed. As a harmful weed, A. cordifolia is reported to have the ability to smother all native vegetation, collapse canopies of tall trees, cultivate as a ground cover and disrupt native seedling development. There is no available information about the involvement of any allelochemicals from A. cordifolia related to these issues. The present study evaluated the allelopathic effect by isolating and identifying the allelopathic substance from A. cordifolia leaf extract. The allelopathic potency of A. cordifolia was determined by a series of bioassays of shoot and root growth on some selected test plants. Separation and purification of the active substances was achieved through several chromatography processes. Finally, the substances with allelopathic activity were identified through high-resolution electrospray ionization mass spectrometry (HRESIMS) analysis and determined by the specific rotation of compound, proton and carbon NMR spectroscopies. The results show that A. cordifolia possesses allelopathic properties which affect other plant species. The isolated compound from the plant material, 3-hydroxy-alpha-ionone, may contribute to the allelopathic effects of A. cordifolia.
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Khan, Farheen, Arvind Singh Jadon, and Poonam Bhadauriya. "Investigation of Antimicrobial and Antioxidant Potential of Tinospora cordifolia by In-vitro Methods." Journal of Drug Delivery and Therapeutics 12, no. 6-S (December 15, 2022): 36–41. http://dx.doi.org/10.22270/jddt.v12i6-s.5843.
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Antimicrobial and Antioxidant Potential of Tinospora Cordifolia were performed by In-vitro Methods. For this study stem of plant Tinospora cordifolia where collected and dried under shade. Morphological characteristics and Physio-chemical parameters of Tinospora cordifolia stem were investigated. Plant materials were extracted by Soxhlet extraction method then Pharmacognostical evaluation of extract was subjected to various phytochemical tests for preliminary identification of various phytoconstituents. The free radicals scavenging potential of standard and extract tested by DPPH method are depicted in with a characteristic absorption at 517nm. Effects of methanolic extract of Tinospora cordifolia was evaluated against gram positive (S. aureus) and gram-negative (E. coli) bacteria and antifungal activity was obtained against Candida Albicans and Aspergilus Niger. Antimicrobial activities were estimated by disk diffusion method. Antimicrobial activities of methanolic extract of stem of tinospora were evaluated in the term of zone of inhibition. Methanolic steam extract of Tinospora cordifolia was significantly against both gram positive (Staphylococcus aureus) and gram-negative bacteria (E. coli). it was observed that the extract was not significantly effective against both gram positive and gram negative bacteria, while, Methanolic stem extract of Tinospora cordifolia was more effective against Candida Albicans and A niger.
Keyword: Tinospora cordifolia, antioxidant, Antimicrobial,
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Pan, Li, Cesar Terrazas, Claudio M. Lezama-Davila, Nirmala Rege, Judith C. Gallucci, Abhay R. Satoskar, and A. Douglas Kinghorn. "Cordifolide A, a Sulfur-Containing Clerodane Diterpene Glycoside from Tinospora cordifolia." Organic Letters 14, no. 8 (April 12, 2012): 2118–21. http://dx.doi.org/10.1021/ol300657h.
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Edwards, Peter J. "NEPHROLEPIS CORDIFOLIA Oleandraceae." Curtis's Botanical Magazine 8, no. 3 (August 1991): 112–18. http://dx.doi.org/10.1111/j.1467-8748.1991.tb00371.x.
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Rakotonasolo, Franck. "955. DICHAETANTHERA CORDIFOLIA." Curtis's Botanical Magazine 37, no. 3 (September 2020): 332–40. http://dx.doi.org/10.1111/curt.12347.
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Kumari, Priyanka, Satish Kumar Sharma, and Snigdha Tiwari. "Evaluation of antihyperlipidemic and antioxidant activity of Rubia Cordifolia Linn." Journal of Drug Delivery and Therapeutics 9, no. 1 (January 15, 2019): 211–15. http://dx.doi.org/10.22270/jddt.v9i1.2216.
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Hyperlipidemia is major problem among population those, who have sedentary life style. The effects of ethanolic and aqueous root extract of Rubiacordifoliain experimentally induced hyperlipidemic rats were investigated. 42 wistar rats of both sexes were used for the study. The animals were completely randomized into seven groups comprising 6 animals each. The groups were treated as follows: Group I: normal diet (ND); Group II: HFD ( Vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day); Group III: HFD + Atorvastatin (10 mg/kg/day); Group IV: HFD+ ethanolic extract of roots of Rubia cordifolia low dose(200 mg/kg/day); Group V: HFD + ethanolic extract of roots of Rubia cordifolia high dose (400 mg/kg/day); Group VI: HFD + aqueous extract of roots of Rubia cordifolia low dose (200 mg/kg/day); Group VII: HFD + aqueous extract of roots of Rubia cordifolia high dose (400 mg/kg/day). Hypercholesterolemia was induced by feeding the animals with high fat diet for 21 days before administration of the extract. After 21thday of feeding, administration of extract lasted for 14 days. Preliminary phytochemical screening revealed that the ethanolic and aqueous root extract of Rubia cordifolia contains glycosides, triterpenoids, saponins, alkaloids and flavonoids. Overall, findings from the present study suggest that the antihyperlipidemic activity observed with Atorvastatin (10mg/kg oral) and the ethanolic extracts of Rubia cordifolia (400mg/kg) showed better activity thanaqueous extracts of Rubia cordifolia (200mg/kg).
Keywords: Rubia cordifolia, body weight, high fat diet, serum lipid, anti-hyperlipidemic activity.
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Ikponmwosa-Eweka, Omorede, Eromosele I. Austin, Nkeiruka Eluehike, and Kissinger Obasogie Orumwensodia. "Analytical comparison of the phytochemical composition and antioxdant actvity of methanol extracts derived from Alchornia cordifolia and Corchorus olitorius." Journal of Phytomedicine and Therapeutics 19, no. 1 (July 24, 2020): 364–74. http://dx.doi.org/10.4314/jopat.v19i1.5.
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Oxidative stress is an underlying pathological state in cancer, cardiovascular disease and diabetes. Medicinal plants are considered to be potential remedies for attenuating oxidative stress in these pathologies because they possess antioxidants. Thus, the quantity and activity of antioxidants in Alchornia cordifolia and Corchorus olitorius methanol leave extracts were evaluated in this study using phytochemical screening, 1,1 diphenyl-2-picrylhydrazyl (DPPH)free radical-scavenging ability, ferric reducing antioxidant power (FRAP) and reducing power assays. Qualitative phytochemical analysis showed that the two plant extracts had alkaloids, saponins, reducing sugar, terpenoids, flavonoids and tannins. While the quantitative phytochemical test revealed a greater presence of total flavonoids and proanthocyanidins (p<0.05) in Corchorus olitorius methanol extract compared to A. cordifolia methanol extract. Contrastingly, the quantities of total tannins and phenols were higher in Alchornia cordifolia methanol extract than in Corhorus olitorius extract. The capacity of Alchornia cordifolia to mop up DPPH (IC50= 0.01μg/mL) was greater than that of ascorbic acid (IC50= 0.055μg/mL) and C. olitorius extract (IC50= 33.10μg/mL) respectively. Ferric reducing potential of C. olitorius (479.80μM Fe(II)/g and A. cordifolia methanol extracts(510 μM Fe(II)/g) were significantly lower (p<0.05) than what was obtained for ascorbic acid (1005μM Fe(II)/g). A. cordifolia methanol extract demonstrated higher reducing power than C. olitorius methanol extract at identical concentrations. Our findings indicated that Alchornia cordifolia could be used as a rich source of antioxidants to alleviate oxidative stress underlying many chronic diseases.
Keywords: Alchornia cordifolia, Corchorus olitorius, phytochemicals, antioxidants
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Alice Christine, Ekissi, Kouamé kan Benjamin, Koko Anauma Casimir, Koffi Kouakou Levi Moïse, and Kati-Coulibaly Séraphin. "Différents usages d’Alchornea cordifolia (Euphorbiaceae) dans la localité de Daloa (Côte d’Ivoire)." Journal of Applied Biosciences 160 (April 30, 2021): 16507–20. http://dx.doi.org/10.35759/jabs.160.7.
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Objectif : Ce travail vise à connaitre les différentes utilisations d’Alchornea cordifolia dans la localité de Daloa (Côte d’Ivoire). Méthodologie et résultats : Il a été mené sous forme d’enquête, auprès des tradipraticiens, des vendeuses et des consommateurs d’Alchornea cordifolia dans la ville de Daloa. Les résultats indiquent que les feuilles sont utilisées à 60,7 % par les enquêtés. Le type de changement observé au cours des différents temps de préparation est préférentiellement la couleur (60,71 %), suivi de la saveur (29,28 %) et enfin de l’arôme 10 %. Les feuilles séchées sont les plus consommées (87,71 %) contre 14,28 % des feuilles fraîches. Le nom vernaculaire est fonction du groupe ethnique. Alchornea cordifolia est une plante qui est utilisée plus pour ses vertus médicinales (83,70 %) que nutritionnelles (16,30 %). Les enquêtés (84,29 %) souhaitent la transformation des feuilles d’Alchornea cordifolia sous forme de thé. Conclusions et application des résultats. Il ressort de cette enquête que, Alchornea cordifolia est une plante qui possède des vertus nutritionnelles et médicinales. Les organes de cette plante sont utilisés en pharmacopée traditionnelle. Les feuilles sont les parties les plus utilisées chez cette plante. Les feuilles sont les organes permanents sur les plantes et donc disponibles sur toute l’année. La transformation des feuilles de cette plante en thé ou en tisane pourrait contribuer à l’amélioration de l’état nutritionnel des populations de la Côte d'Ivoire. Mots clés : Alchornea cordifolia, tisane, nom vernaculaire, thé. 16507 Ekissi et al., J. Appl. Biosci. Vol.160 :2021 Différents usages d’Alchornea cordifolia (euphorbiaceae) dans la localité de Daloa (Côte d’Ivoire) ABSTRACT Objective: This work aims to learn about the different uses of Alchornea cordifolia in the locality of Daloa (Côte d'Ivoire). Methodology and results: It was carried out in the form of a survey among traditional healers, sellers and consumers of Alchornea cordifolia in the town of Daloa. The results obtained that the leaves are used at 60.7% by the respondents. The type of study change during the different preparation times is preferably the color (60.71%), followed by the flavor (29.28%) and finally the 10% aroma. Dried leaves are the most consumed (87.71%) against 14.28% of fresh leaves. The vernacular name is a function of the ethnic group. Alchornea cordifolia is a plant that is used more for its medicinal (83.70%) than nutritional (16.30%) virtues. Respondents (84.29%) want Alchornea cordifolia leaves to be transformed into tea. Conclusions and application of the results. It emerges from this investigation that, Alchornea cordifolia is a plant which has nutritional and medicinal virtues. The organs of this plant are used in traditional pharmacopoeia. The leaves are the most used parts of this plant. Leaves are the permanent organs on plants and therefore available throughout the year. The transformation of the leaves of this plant into tea or herbal tea could help improve the nutritional status of the populations of Côte d'Ivoire. Key words: Alchornea cordifolia, herbal tea, vernacular name, tea
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Lin, An-Pang, Wei-Jern Tsai, Chi-Yen Fan, Ming-Jen Lee, and Yuh-Chi Kuo. "Vandellia Cordifolia Regulated Cell Proliferation and Cytokines Production in Human Mononuclear Cells." American Journal of Chinese Medicine 28, no. 03n04 (January 2000): 313–23. http://dx.doi.org/10.1142/s0192415x00000374.
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Vandellia cordifolia (V. cordifolia) used for treatment inflammation in traditional Chinese medicine was selected for immunopharmacological activity test. The effects of V. cordifolia extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that VC-ME fraction suppressed HMNC proliferation activated with phytohemagglutinin (PHA) and stimulated cell cycle progression was arrested at the G0/G1 stage. The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-γ (IFN-γ) production, since VC-ME suppressed IL-2 and IFN-γ production of HMNC in a dose-dependent manner. Therefore, it is suggested that immunomodulatory agents are contained in V. cordifolia.
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Wardani, Kharisma Kusuma. "Perbandingan Aktivitas Antioksidan Ekstrak Daun Binahong Merah (Anredera cordifolia ) Dengan Perbedaan Jenis Pelarut Dan Waktu Ekstraksi." Indonesian Journal of Health Science 4, no. 2 (April 1, 2024): 138–45. http://dx.doi.org/10.54957/ijhs.v4i2.532.
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Daun binahong merah (Anredera cordifolia) sering digunakan sebagai obat tradisional. Beberapa faktor mempengaruhi proses ekstraksi meliputi waktu dan kepolaran pelarut. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan daun binahong merah (Anredera cordifolia) dengan pelarut etanol, etil asetat dan n-heksan dan waktu ekstaksi 3, 5, 7 hari. Daun binahong merah (Anredera cordifolia) diekstraksi dengan metode maserasi dengan 9 jenis perlakuan meliputi penggunaan pelarut etanol, n-heksan dan etil asetat.dengan waktu 3, 5, 7 hari. Kemudian dilakukan uji skrinning fitokimia dan uji aktifitas antioksidan dengan metode DPPH. Hasil uji skrinning fitokimia ekstrak daun binahong merah (Anredera cordifolia) dengan perbedaan pelarut dan waktu ekstraksi diperoleh hasil dengan perbedaan yang signifikan pada hasil uji saponin dan uji triterpenoid/steroid. Aktivitas antioksidan daun binahong (Anredera cordifolia) dengan perbedaan jenis pelarut etanol, etil asetat dan n-heksan dengan variasi lama waktu ekstraksi diperoleh hasil nilai paling tinggi 95,70 μg/mL dari pelarut etanol dengan variasi lama waktu ekstraksi 3 hari.
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Dalu, Aishwarya P., Vinayak S. Zagare, Priyamala E. Avchar, Megha P. Kadam, Ashwini S. Ingole, Shatrughna U. Nagrik, and Prashant A. Patil. "A Pharmacological Potential of Adina cordifolia." Journal of Drug Delivery and Therapeutics 11, no. 2-S (April 15, 2021): 132–35. http://dx.doi.org/10.22270/jddt.v11i2-s.4652.
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Adina cordifolia belongs to the Rubiaceae family. Flavonoids, carbohydrate, alkaloid, saponin, phenol, tannins, terpenoids, and cardiac glycosides were found in Adina cordifolia plant extracts. Herbal medicines have been the highly esteemed source of medicine throughout human history. They are widely used today indicating that herbs are a growing part of modern, high-tech medicine. The medicinal plants, besides having natural therapeutic values against various diseases and considerable works have been done on these plants to treat chronic Cough, Jaundice, Stomachaches, Cancer, Diabetes, and a variety of other ailments. Present review deals with botanical description and various pharmacological action, and medicinal uses of Adina cordifolia.
Keywords: Adina cordifolia, Pharmacological Potential, Extract, Taxonomy.
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Nithin Krishna, K., Kalaiselvi Krishnamoorthy, Vishnu Priya Veeraraghavan, and Selvaraj Jayaraman. "In vitro Biological Properties and in Silico Studies on Tinospora Cordifolia Stem Aqueous Extract." Journal of Pharmacy and Bioallied Sciences 16, Suppl 2 (April 2024): S1317—S1320. http://dx.doi.org/10.4103/jpbs.jpbs_598_23.
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ABSTRACT Tinospora cordifolia, commonly known as “Giloy” or “Guduchi,” is a medicinal plant with a rich history in traditional medicine systems. The aqueous extract of Tinospora cordifolia stems has garnered attention due to its reported pharmacological activities. This study aimed to investigate the in vitro biological properties of the aqueous extract and complement the findings with in silico studies to gain insights into potential molecular interactions. The Tinospora cordifolia stem aqueous extract was subjected to a battery of in vitro assays to assess its biological properties. Anti-inflammatory activity was evaluated using invitro assay. To complement the in vitro findings, in silico studies involving molecular docking analyses were conducted to predict potential interactions between the extract’s constituents and relevant biomolecular targets. The in vitro evaluation revealed significant anti-inflammatory activity of the Tinospora cordifolia stem aqueous extract, as evidenced by its ability to suppress the production of pro-inflammatory cytokines. In silico studies provided insights into the molecular interactions between the extract’s bioactive constituents and key inflammatory and antioxidant targets, further supporting the observed biological properties. The combined in vitro biological assays and in silico studies offer a comprehensive assessment of the Tinospora cordifolia stem aqueous extract’s potential therapeutic properties. The demonstrated anti-inflammatory activities align with the traditional use of Tinospora cordifolia and suggest its potential in managing inflammatory and oxidative stress-related disorders. The in silico insights provide a molecular understanding of the extract’s mode of action, strengthening the rationale for further investigation and development of natural products derived from Tinospora cordifolia for pharmaceutical and medicinal applications.
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Rodrigue, Bou, N’Go Kouadio Pacôme, Diané Fatoumata, Kangah N’da Kouassi Augustin, Kprié Koffi Marius, and Tako Némé Antoine. "Alchornea cordifolia Aqueous Extract Relieves Adulthood Cognitive Disorders and Oxidative Damages Due to LPS-Induced Neuroinflammation in Neonatal Wistar Rats." Haya: The Saudi Journal of Life Sciences 9, no. 05 (May 17, 2024): 194–201. http://dx.doi.org/10.36348/sjls.2024.v09i05.005.
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Alchornea cordifolia extract is widely used as ethnomedicine in Ivory coast to treat various ailments related to bacterial, fungal, parasitic and inflammatory disorders, infertility problems, among other. Here, the objective was to evaluate some long lasting neuroprotective properties of Alchornea cordifolia extract against a rat’s model of LPS-induced early-life neuroinflammation. The neuroinflammation was induced with a single dose of LPS (1mg/kg, i.p) in neonatal rats (postnatal day 4) or PBS rats (1ml/100g, vehicle). Six hours later, some LPS rats were treated either with minocycline (50 mg/kg, i.p) or Alchornea cordifolia extract (200 or 400 mg/kg, p.o) for 14 consecutive days. Then, rats were followed carefully till adulthood (P 90) for the evaluation of cognitive behavioral status and oxidative damage level in hippocampus and prefrontal cortex. Results showed that the treatment with Alchornea cordifolia extract (200 or 400 mg/kg) attenuated LPS-induced deficits of spatial learning and memory (Y-maze and Morris water maze) and recognition memory (Object recognition test). However, only dose of 200 mg/kg of Alchornea cordifolia extract reduced significantly lipid peroxidation through MDA content and enhanced the enzymatic antioxydant SOD level in hippocampus and prefrontal cortex. On the whole, the threshold dose 200 mg/kg of Alchornea cordifolia demonstrated long lasting beneficial neuroprotective effects against LPS-induced early-life neuroinflammation incomparable to reference molecule minocycline. This findings suggest that Alchornea cordifolia rich in quercitrin bioactive need further biochemical and histopathology studies before promising as efficient therapeutic agent against neurodegenerative and psychiatric diseases.
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Royani, Ahmad, Muhammad Hanafi, Heddy Julistiono, Achmad Dinoto, Puspa Dewi N. Lotulung, and Azwar Manaf. "The Potential of Tinospora cordifolia Extracts as Antibacterial Material against Pseudomonas aeruginosa." Trends in Sciences 20, no. 1 (November 28, 2022): 3884. http://dx.doi.org/10.48048/tis.2023.3884.
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Mitigation and control of bacterial corrosion must have been prioritized for failure anticipation by corrosion associated with microorganisms. Using synthetic inhibitor for material protection from corrosion have problems because it is not eco-friendly. This work conducted preliminary studies on T. cordifolia stem extracts at various methanol ratios against P. aeruginosa biofilm as a new eco-friendly inhibitor. The T. cordifolia stem was extracted by the maceration method with a different ratio of methanol solvent (100, 75 and 50 %). The bacterial activity was assessed using the dilution method (MTT assay) to determine the minimum inhibitory concentration (MIC). The total phenolic and flavonoid contents were determined using Follin-Ciocalteu and aluminum chloride (AlCl3) colorimetric, respectively. Meanwhile, the structure of the active compounds in the extract was identified by using the liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The yields of T. cordifolia extracts are 9.45, 7.56 and 8.40 % at 100, 75 and 50 % of methanol ratios, respectively. The total phenolic content (TPC) in crude methanol extract of T. cordifolia is 11.20, 9.46 and 6.56 % for 100, 75 and 50 % of methanol ratios. Meanwhile, the flavonoid content (TFC) was obtained is about 5.25, 0.64 and 0.33 % for 100, 75 and 50 % of methanol concentrations, respectively. The T. cordifolia extract has antibacterial activity against P. aeruginosa in all ratios of methanol concentrations. The minimum inhibitory concentration (MIC) of T. cordifolia methanol extract was found at 4096 µg/mL. Methanol solvent concentration with the most active antibacterial activity of the extract was 50 %, followed by 75 and 100 %. The structures of the active compound in the methanolic extract of T. cordifolia are a phenolic group, and it is in the alkaloid derivatives (Calopiptin, d-Lirioferine (Lirioferine), Moupinamide, Piperanine, and Yuanhunine). HIGHLIGHTS The crude methanol extract of Tinospora cordifolia stem has potential against aeruginosa in the marine environment The minimum inhibitory concentration (MIC) was found at 4096 µg/mL of extract in a ratio of 50:50 (v/v) of methanol to water The compound structures in cordifolia methanol extracts are Calopiptin, d-Lirioferine (Lirioferine), Moupinamide, Piperanine, and Yuanhunine GRAPHICAL ABSTRACT
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Oparaku, E., and E. Osarolube. "Effects of Alchornea cordifolia leaf extract on the mechanical properties of mild steel in acidic medium." Scientia Africana 19, no. 3 (February 24, 2021): 55–62. http://dx.doi.org/10.4314/sa.v19i3.5.
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The effect of Alchornea Cordifolia leaf extract on the mechanical properties of mild steel in acidic medium was studied using weight loss method. The first sample was not introduced to any medium. It served as the control1 sample. The second sample was introduced to a medium containing 0.2M Sulphuric acid solution in the absence of the Alchornea Cordifolia leaves extract for 21 days, while the third sample was immersed in a vessel containing 0.2M sulphuric2 acid and 0.5g/L of Alchornea Cordifolia leaves extract as an inhibitor for 21 days. Results obtained showed a substantial improvement on the mechanical properties of mild steel exposed to the medium with the inhibitor.
Keywords: Mechanical Properties, Corrosion, Inhibition, Alchornea Cordifolia, Sulphuric acid
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Liu, Baixue, Yaqin Tan, Xuan Hu, Xu Gao, and Youguang Ao. "Research Progress on the Role of Rubia cordifolia in the Treatment of Lichen Planus." Dermatological Health 2, no. 1 (March 29, 2024): 26–31. http://dx.doi.org/10.26689/dh.v2i1.6601.
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Lichen planus is a chronic inflammatory skin disease. Due to its unclear etiology, the treatment is slow and complicated. Rubia cordifolia is a drug with a long history, with the effects of cooling blood and removing blood stasis, promoting blood circulation, and dredging meridians. Modern research suggests that the components of Rubia cordifolia have the effects of immune regulation, anti-inflammation, liver protection, and antioxidation. It may be a potential drug for the treatment of lichen planus. However, the specific mechanism of Rubia cordifolia in the treatment of this disease is still under study. This article reviews the mechanism of Rubia cordifolia in the treatment of lichen planus, in order to provide references for the clinical application of the drug.
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Chandel, Ekta, and Shraddha Chintalwar. "Phytochemical and Antimicrobial Activity of Fumes and Powder Extracts of Tinospora cordifolia." Interdisciplinary Journal of Yagya Research 5, no. 2 (October 31, 2022): 09–14. http://dx.doi.org/10.36018/ijyr.v5i2.90.
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Herbal medicines have a long therapeutic history and are still serving many of the health needs of a large population of the world. However, the quality control and quality assurance still remains a challenge because of the high variability of chemical components involved. T. cordifolia is commonly referred to as Amrita or Guduchi. All the parts of the plant are immensely useful due to the presence of different secondary metabolites. We aimed to investigate the qualitative and quantitative (carbohydrate and poly-phenolic compound) analysis of secondary metabolites present in extracts of Tinospora cordifolia powder and its herbal fume (generated from Yagya), followed by the study of its antimicrobial activity against E. coli and P. aeruginosa. The present study's powder and fume cocktail (hexane, ethyl-ether and methanol) extracts (10 mg/ml) showed 30 mm and 21.67 mm Zone of inhibition against E.coli respectively indicating equivalent efficiency of herbal fumes. Similarly, fumes contained all secondary metabolites qualitatively to that of powder extract. In addition, carbohydrate and poly-phenolic compound present in the fume extracts (0.277 mg/g and 0.29mg/g), were equivalent or higher than powder extracts (0.131 mg/g and 0.26mg/g) indicating Tinospora cordifolia's fume holistic utility.
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Damayanti, Sevira Putri, Ria Mariani, and Doni Anshar Nuari. "Studi Literatur : Aktivitas Antibakteri Daun Binahong (Anredera cordifolia) terhadap Staphylococcus aureus." Jurnal Farmasi Sains dan Terapan 9, no. 1 (February 2022): 42–48. http://dx.doi.org/10.33508/jfst.v9i1.3367.
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Staphylococcus aureus merupakan bakteri yang dapat menyebabkan infeksi. Pengobatan infeksi biasanya menggunakan antibiotik, namun ditemukan masalah dalam penggunaan antibiotik salah satunya resistensi antibiotik. Binahong (Anredera cordifolia) dapat dijadikan sebagai alternative pengobatan antibakteri. Tujuan artikel review ini adalah untuk mereview ekstrak daun binahong yang dapat berpotensi menghambat pertumbuhan bakteri Staphylococcus aureus termasuk didalamnya menggali informasi mengenai konsentrasi yang memberikan zona hambat terhadap pertumbuhan Staphylococcus aureus dan golongan senyawa yang bertanggungjawab terhadap aktivitas antibakteri Staphylococcus aureus. Hasil uji antibakteri terhadap ekstrak daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan metode difusi pada konsentrasi 10%, 15%, 20% dengan diameter zona hambat 1,7 mm, 2,0 mm, 2,6 mm, sedangkan pada metode dilusi pada konsentrasi 25%. Pada fraksinasi daun binahong (Anredera cordifolia) dapat menghambat pertumbuhan Staphyloccus aureus (MIC 512 µg/ml). Hal ini dapat dikatakan bahwa ekstrak daun binahong (Anredera cordifolia) berpotensi dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Golongan senyawa yang terkandung dalam ekstrak daun binahong (Anredera cordifolia) diduga adanya senyawa alkaloid, steroid, flavonoid dan fenol yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus.
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Singh, Deepika, and Prabir K. Chaudhuri. "Chemistry and Pharmacology of Tinospora cordifolia." Natural Product Communications 12, no. 2 (February 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200240.
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Tinospora cordifolia (Menispermaceae) is an Ayurvedic medicinal plant distributed throughout the Indian subcontinent and China. The whole plant is used in folk and the Ayurvedic system of medicine alone and in combination with other plants. Due to its commercial importance, T. cordifolia has been of intense research interest for the last four decades with the isolation of diverse compounds such as alkaloids, sesquiterpenoids, diterpenoids, phenolics, steroids, aliphatic compounds and polysaccharides, along with the discovery of a wide spectrum of pharmacological properties like immunomodulation, anticancer, hepatoprotective and hypoglycemic. Although pharmacological activities of extracts and compounds of T. cordifolia have been studied both in vitro and in vivo, only few mechanisms of action have been explored and need further elaboration. In the present review, the pharmacological activities of compounds and different extracts of T. cordifolia are highlighted, along with those of the marketed products, showing the relevance of phytochemicals and the standardization of the marketed products for medicinal use. This compilation of the extensive literature of T. cordifolia here will be a referral point for clinical study and the development of standardized phytomedicines in healthcare.
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Arshad, S., I. Hussain, M. Ibrahim, M. Imran, M. A. Assiri, S. Thind, M. Bilal, A. Irfan, and A. G. Al-Sehemi. "Biochemical studies on protein, phenolic contents and antioxidant activities of Sida cordifolia extracts." Bulletin of the Chemical Society of Ethiopia 34, no. 2 (October 28, 2020): 427–34. http://dx.doi.org/10.4314/bcse.v34i2.18.
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The study aimed to characterize the antioxidant properties regarding the Sida cordifolia with special reference to its detailed biochemical analysis. The study revealed that chlorophyll A (0.9 ± 0.3 mg/g), total chlorophyll content (3.0 ± 0.7 mg/g), total carotenoid content (0.3 ± 0.1 mg/g), total soluble proteins (7.5 ± 0.1 mg/g), and total phenolic contents (5.6 ± 1.3 mg/g) were found highest in flower tissue of S. cordifolia. However, peroxidase (POD) contents (118 ± 31 units/g), superoxide dismutase (SOD) activity (64 ± 1.5 units/g) were maximum in the leaf tissues, while catalase (CAT) contents (133 ± 25 units/g), ascorbate peroxidase (APX) contents (145 ± 44 units/g) were also found more in the flowers of S. cordifolia rather than other parts. Our results conclude that leaves, stem, flower of S. cordifolia could be exploited in pharmacology due to presence of different antioxidants reflected in flower and leaf extract make them potent and profound therapeutic agents.
KEY WORDS: Alkaloids, Flavonoids, Phenolics, Antioxidant, Sida cordifolia
Bull. Chem. Soc. Ethiop. 2020, 34(2), 427-434
DOI: https://dx.doi.org/10.4314/bcse.v34i2.18
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Cut Bidara Panita Umar, Amelia Niwelle, and Syntia Clarce Ririmasse. "Uji Aktivitas Antibakteri Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Ten.) Steenis) Terhadap Bakteri Staphylococcus Epidermidis." Jurnal Pengabdian Ilmu Kesehatan 2, no. 2 (February 21, 2023): 78–85. http://dx.doi.org/10.55606/jpikes.v2i2.1277.
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. Daun binahong (Anredera cordifolia Ten. Stennis) merupakan salah satu tanaman yang dapat mengobati berbagai jenis penyakit. Hal ini dikarenakan tanaman ini memiliki kandungan sebagai antibakteri dan antivirus, daun binahong (Anredera cordifolia Ten. Stennis) memiliki khasiat obat tradisional sebagai antibakteri.Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa serta mengetahui besarnya aktivitas zona hambat pada ekstrak daun binahong (Anredera cordifolia Ten. Stennis). Metode yang digunakan pada penelitian ini yaitu eksperimental laboratorium dengan menggunakan metode maserasi pada ekstrak daun binahong dan metode difusi agar sumuran dengan tiga konsentrasi yang berbeda yaitu 60%, 80%, 100%. Berdasarkan hasil penelitian menunjukan bahwa ekstrak daun binahong (Anredera cordifolia Ten. Stennis) memiliki komponen senyawa alkaloid, flavonoid, tanin dan saponin. Ekstrak etanol daun binahong (Anredera cordifolia Ten. Stennis) mampu menghambat bakteri Staphylococcus Epidermidis dengan diameter zona hambat konsentrasi 60%;17mm, konsentrasi 80%;26, dan konsentrasi 100%;30mm. Kesimpulan dari penelitian ini yaitu ekstrak daun binahong terkandung senyawa alakaloid, flavanoid, tanin dan saponin dengan memiliki konsentrasi ekstrak yang paling efektif menghambat bakteri staphylococcus epidermidis pada konsentrasi 100% diameter zona sebesar 30mm.
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Firdaus, Mutiara Nurul Aulia, Widya Kardela, and Ifora Ifora. "Phytochemical and Anti-Inflammatory Potential of Anredera cordifolia (Ten): A Review." Journal of Drug Delivery and Therapeutics 12, no. 2 (March 15, 2022): 121–25. http://dx.doi.org/10.22270/jddt.v12i2.5228.
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Objective : Inflammation is a manifestation of the immune response to eliminate antigens from the body. This process will occur until the antigen is eliminated from the body. This inflammatory process can occur locally or systemically. Anredera cordifolia (Ten) has been used as a traditional medicine as a therapy for inflammation, diabetes, kidney failure, hypertension, hyperlipidemia, and others. Therefore, this review aims to provide current information and obtain a comprehensive review of the anti-inflammatory activity of Anredera cordifolia (Ten).
Methods : This review provides evidence in the literature for the phytochemical and anti-inflammatory activity of Anredera cordifolia (Ten), from August 2011-August 2021. Three bibliographic databases were used as the main sources of information (Pubmed, ScienceDirect, and Google scholar). The keywords used in this research are as follows: “Phytochemical”, “anti-inflammatory”, “Bioactive compounds”, “Pharmacology” and “Anredera cordifolia”.
Results: A total of 10 studies were included in this review according to the required criteria, 5 of which were concerning phytochemical and 5 were concerning anti-inflammatory. Anredera cordifolia (Ten) contains many secondary metabolites such as essential oil, saponins, phenolics, rauninflammatory activity of Anredera cordifolia (Ten) occur mainly through several mechanisms including a decrease in the volume of paw edema, inhibition of hemolysis, inhibition of the inflammatory mediators TNF-α, IL-1β, IL-6, and NO, and a decrease in the number of neutrophil PMNs.
Conclusions: Recent interest in the traditional treatment of the Anredera cordifolia (Ten) plant both in vitro and in vivo has shown potential anti-inflammatory activity attributed to the presence of natural bioactive compounds.
Keywords : Anti-inflammatory, Anredera, Phytochemical, Pharmacology
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Jibira, Yakubu, Elizabeth Cudjoe, Frederick M. Tei-Maya, Benjamin Ayensu, and Linda E. Amoah. "The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro." Journal of Parasitology Research 2020 (November 18, 2020): 1–6. http://dx.doi.org/10.1155/2020/8836771.
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Background. Drug resistance in malaria is a global problem, with reports of Plasmodium parasites resistant to the current first-line antimalarial drug, artemisinin, expanding from Southeast Asia to Africa. There is therefore an urgent need to identify new drug candidates that will be effective against the existing malaria parasites. Drug combination therapy presents a myriad of advantages over monotherapy including delayed onset of resistance, potentiation, and synergism. This present study explored the effectiveness of combinations of aqueous extracts of Alchornea cordifolia (A. cordifolia) and Mangifera indica (M. indica) at clearing both laboratory and field isolates of P. falciparum. Methods. Synchronized ring stage cultures of field (FA08) and laboratory strains (NF54 and CamWT_C580Y) of P. falciparum were subjected to combinations of different concentrations and ratios of aqueous extracts of A. cordifolia and M. indica. The growth inhibition of the individual plant extracts and their combinatory effects were studied in vitro using SYBR Green I drug assay. Results. The A. cordifolia extract exhibited 50% inhibitory concentration (IC50) of 2.71, 7.80, and 3.56 μg/mL against the NF54, CamWT_C580Y, and FA08 parasite strains, respectively. Mangifera indica exhibited IC50 of 18.11, 20.08, and 10.23 μg/mL against the NF54, CamWT_C580Y, and FA08 parasite strains, respectively. Additive, synergistic and antagonistic interactions were observed at different combinations of A. cordifolia and M. indica extracts. Conclusion. A combination product containing A. cordifolia and M. indica has the potential to serve as an effective antimalarial as majority of the tested combinations of aqueous extracts of A. cordifolia and M. indica extracts exhibited synergistic effects in vitro against the NF54, CamWT_C580Y, and FA08 P. falciparum strains.
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Ghori, Syed Safiullah, Syeda Seema Zaidi, Mohammed Sufian Aamer, Daraksha Fatima, and Abdul Hannan. "A Study on Pharmacological Evaluation of Diuretic Activity of Tinospora cordifolia Stem Ethanolic Extract." UTTAR PRADESH JOURNAL OF ZOOLOGY 44, no. 21 (October 19, 2023): 350–55. http://dx.doi.org/10.56557/upjoz/2023/v44i213708.
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This study aimed to assess the diuretic effects of Tinospora cordifolia stem ethanolic extract in Swiss Albino Rats. The administration of the higher dose (200 mg/kg) of the ethanolic extract derived from the stem part of Tinospora cordifolia resulted in a significant increase in diuresis during the 6th hour, with a measured output of 1.93 + 1.21ml, compared to the control group (0.38+ 0.12 ml). This effect was also compared to the reference standard, furosemide, which produced an output of 2.45 + 1.12ml (p < 0.05). Similarly, the higher dose (400 mg/kg) of Tinospora cordifolia stem extract demonstrated significant diuretic activity (2.70 + 1.15 ml) compared to the control group (1.14 + 0.09 ml) (p < 0.05). The increase in urine output was statistically significant (p < 0.01). The study also analysed the impact of furosemide (10 mg/kg) and Tinospora cordifolia extracts at doses of 200 mg/kg and 400 mg/kg on the excretion of electrolytes (Na+ and K+) in the 6-hour urine samples. The pH of the urine samples following treatment with Tinospora cordifolia stem extract at doses of 200 mg/kg and 400 mg/kg was measured to be 5.48 and 6.79, respectively. The results obtained in this study provide a quantitative basis for explaining the diuretic activity of Tinospora cordifolia. The extract displayed notable diuretic activity, thus supporting its traditional use as a diuretic in ethno-pharmacology. Further investigations, including phytochemical and pharmacodynamic studies, are necessary to identify the active constituents responsible for this activity and to understand the exact mechanism of the diuretic effect exhibited by the aqueous extract of Tinospora cordifolia.
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Maheshwari V. Vyas, Janani, Senthil Kumar S., Leena Dennis Joseph, Kalaivani P., and Siva R. "Co-administration with Tinospora cordifolia attenuates drug induced nephrotoxicity – A histological and biochemical assessment." Biomedicine 43, no. 3 (July 1, 2023): 835–42. http://dx.doi.org/10.51248/.v43i3.1698.
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Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug. Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading. Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium. Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.
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Sharma, Bhupendra, Rishi Dewangan, and Shyam Sharma. "Characterizing the mechanical behavior of eco-friendly hybrid polymer composites with jute and Sida cordifolia fibers." Metal Working and Material Science 26, no. 3 (September 13, 2024): 267–85. http://dx.doi.org/10.17212/1994-6309-2024-26.3-267-285.
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Introduction. Recognition of the medicinal properties of plants is an integral part of traditional Indian health systems such as Unani, Siddha, Naturopathy and Ayurveda. Among others, Sida cordifolia, a member of the Malvaceae family, is especially celebrated in Ayurvedic medicine for its outstanding chemical properties. This plant grows in the subtropical and tropical climate of India and symbolizes the global shift towards more environmentally friendly materials. Given the rising environmental concerns, there is an increased demand for biodegradable and renewable resources for industrial applications, especially for reinforcing polymer matrices with natural fibers. The purpose of this study is to investigate the effectiveness of Sida cordifolia fibers combined with jute for reinforcing polylactic acid (PLA) composites. This highlights its potential to improve both environmental quality and mechanical properties of materials. Materials and method. The study involved the fabrication of four different composite specimens: : a solely 4-layered jute fiber mat, untreated Sida cordifolia fibers combined with a 4-layered jute mat, and Sida cordifolia fibers treated with benzoylation combined with a 4-layered jute mat. These composites were subjected to mechanical testing focusing on tensile strength and flexural strength. Its microstructural analysis was also carried out. Results and discussion. The results show that benzoylation-treated Sida cordifolia fibers exhibit significantly higher strength compared to its untreated counterparts. At the same time, an increase in the proportion of Sida cordifolia fibers in composites while maintaining a constant total mass correlates with an increase in the strength of the materials. These results indicate that Sida cordifolia and jute fiber-reinforced PLA composites can provide a competitive, environmentally friendly alternative to synthetic fiber-reinforced composites in a variety of industrial applications. In conclusion, treated natural fibers like Sida cordifolia can significantly improve the mechanical properties of polymer composites, supporting its use as environmentally friendly, high-performance materials in a variety of industries. This research not only promotes the use of natural fibers for commercial applications, but also contributes to the larger goal of sustainable materials science.
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Herrero-Borgoñón, Juan J. "Nuevos datos sobre la pteridoflora alóctona ibérica." Acta Botanica Malacitana 29 (December 1, 2004): 263–65. http://dx.doi.org/10.24310/abm.v29i0.7236.
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New data about the non-native iberian pterydophyte flora. Palabras clave. Pteridoflora, Corología, Cyrtomium falcatum, Nephrolepis cordifolia, Valencia,Comunidad Valenciana.Key words. Pterydophyte flora, Chorology, Cyrtomium falcatum, Nephrolepis cordifolia, Valencia, Valencian Community.
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GODARA, R., S. I. RAFIQI, R. SHARMA, R. KATOCH, A. YADAV, P. K. PILANIA, and P. K. VERMA. "Acaricidal activity of Alstonia scholaris and Sida cordifolia leaf extracts against Hyalomma anatolicum ticks." Indian Journal of Animal Sciences 90, no. 11 (April 7, 2021): 1461–64. http://dx.doi.org/10.56093/ijans.v90i11.111487.
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Development of acaricidal resistance and environmental pollution has driven need for eco-friendly pesticides and herbal acaricides. Leaf extracts of Alstonia scholaris and Sida cordifolia in four different solvents were used in the range of 0.25-8.0% for larval immersion test against unfed larvae of Hyalomma anatolicum. Mortality rates of larval ticks were in dose-dependent manner ranged from 0.5 to 100% for A. scholaris and from 0.8 to 100% for S. cordifolia. Acetone extract of A. scholaris and methanolic extract of S. cordifolia were most effective against larval ticks with LC50 values of 0.71% and 0.42%, respectively. Significant larvicidal activity of A. scholaris and S. cordifolia leaf extracts against unfed larvae of H. anatolicum qualify them as green pesticides which could be combined with other tools for integrated pest management.
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Adeyemi, S. B., A. I. Afonja, M. B. Odebisi-Omokanye, T. P. Okor, and A. A. Lateef. "Antibacterial Activity of Anthocliesta vogelii (planch) and Tinospora cordifolia/ on Esherichia coli and Pseudomonas aeruginosa." Nigerian Journal of Technological Research 15, no. 3 (November 23, 2020): 50–55. http://dx.doi.org/10.4314/njtr.v15i3.7.
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An ethnobotanical investigation has revealed that the roots of Anthocliesta vogelii and stem bark of Tinospora cordifolia are used by indigenous people in the treatment of pile. This present study evaluated the antibacterial activity of the root and stem bark of Anthocliesta vogelii and Tinospora cordifolia respectively against the human pathogenic gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli. The phytochemical composition of these two plants was also assayed. Graded concentrations of 25mg/ml, 50mg/ml, 100mg/ml and 200mg/ml of the respective crude extract were applied against the test organisms. The percentage yield of the ethanolic extract of T. cordifolia stem and A. vogelii root were 40.978% and 21.872% respectively with their phytochemical analysis revealing the presence of saponins, alkaloids, tannins, flavonoids, and glycosides, with steroids present in A. vogelii but absent in T. cordifolia. The antimicrobial effect of the ethanolic extracts of both plants on the two test bacteria was significant (P<0.05). However, the ethanolic root extract of A. vogelii showed higher inhibition against P. aeruginosa and E. coli than the ethanolic stem extract of T. cordifolia at concentrations of 50mg/ml, 100mg/ml and 200mg/ml, while both extracts did not have any inhibition on the test organisms at a concentration of 25mg/ml. The Minimum Inhibitory Concentrations (MICs) of the ethanolic extract of A. vogelii root on P. aeruginosa and E. coli were 50mg/ml and 100mg/ml respectively, while the MICs for the ethanolic extract of T. cordifolia stem on P. aeruginosa and E. coli was 50mg/ml respectively. Both plant extracts could not kill the test bacteria; hence, they are only bacteriostatic and not bactericidal against the test bacteria.
Keywords: Anthocleista vogelii, Tinospora cordifolia, Bacterial, Bacteriostatic, Bactericidal
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Dwitiyanti, Dwitiyanti, Yahdiana Harahap, Berna Elya, and Anton Bahtiar. "Binahong (Anredera cordifolia (Tenore) Steen.) Leaf Extract Modulates Fatty Acids and Amino Acids to Lower Blood Glucose in High-Fat Diet-Induced Diabetes Mellitus Rats." Advances in Pharmacological and Pharmaceutical Sciences 2021 (April 28, 2021): 1–8. http://dx.doi.org/10.1155/2021/8869571.
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Patients with diabetes are 1.6 times more likely to use complementary alternative medicine than nondiabetic patients. Previous studies have shown that Anredera cordifolia (Tenore) Steen. (A. cordifolia) leaf extract has the capacity to lower blood glucose, but the actual mechanisms are unclear. Therefore, in this study, we explored the effect of A. cordifolia leaf extract on the metabolism of fatty acids and amino acids. Six-week-old male Wistar rats were randomly divided into six experimental groups (n = 5 per group). Two groups were fed with a regular diet or a high-fat diet (HFD) for six weeks. The regular diet and HFD groups were administered with 0.5% carboxymethylcellulose as a vehicle, and HFD rats were also fed with a suspension of glibenclamide (0.51 mg/kg body weight (BW)) or A. cordifolia leaf extract (25, 50, and 100 mg/kg BW). During the whole treatment, BW and food intake were recorded weekly. The rats were euthanized seven weeks after treatment. Blood glucose was evaluated by spectrophotometry, while fatty acids and amino acids were evaluated using a gas chromatography/flame ionization detector (GC/FID). All doses of A. cordifolia administration reduced blood glucose significantly, and 50 mg/kg BW was most effective in lowering blood glucose, similar to the effects of glibenclamide. A. cordifolia leaf extract affected the levels of medium-chain fatty acids, especially at 50 mg/kg BW. In contrast, glibenclamide affected long-chain fatty acids (LCFAs) to lower blood glucose. Based on the analysis conducted, we conclude that administration of A. cordifolia leaf extract can decrease blood glucose levels by regulating fatty acid metabolism and that a dose of 50 mg/kg BW in rats was the optimal dose.
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Oli, Biraj, Gyanendra Ghimire, Bijay Dhakal, Neetu Amatya, Deepjyoti Adhikari, and Netra Lal Bhandari. "Comparative Phytochemical and Biological Study of Tinospora cordifolia (Thunb.) Miers and Justicia adhatoda L. Plants Collected from West Rukum of Nepal." Journal of Nepal Chemical Society 43, no. 2 (April 25, 2023): 91–102. http://dx.doi.org/10.3126/jncs.v43i2.53348.
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Medicinal plants contained an impressive number of modern drugs and are believed to be a precious natural reservoir that has been continuously studied for its pharmacological activities against various ailments. Tinospora cordifolia and Justicia adhatoda are widely used shrubs in folk and ayurvedic systems of medicine. Phytochemical screening of different fractions of the extract of the bark of T. cordifolia and leaf, stem, and flowers of J. adhatoda was done and results show the presence of alkaloids, flavonoids, phenolics, glycosides, terpenoids in both plants. The antibacterial potency of medicinal plant extracts has been tested against Bacillus subtilis ATC6051 and Enterococcus faecalis ATCC29212 by disc diffusion assay. The leaves extract of J. adhatoda showed good antibacterial activities towards both the Enterococcus faecalis and Bacillus subtilis bacteria, however, the extract of T. cordifolia was found not soo effective with those bacteria. The methanol extract of T. cordifolia stem showed the strongest 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity with IC50 values 8.213μg/mL very close to standard ascorbic acid (22.451 μg/mL). Furthermore, results showed that T. cordifolia is a good source of antioxidants as compared to the J. adhatoda. The total phenolic content (TPC) was highest in methanolic extract of T. cordifolia (46.463 mg GAE/g extract) while the J. adhatoda had lower values (31.167 mg GAE/g extract) by taking gallic acid as a standard. The total flavonoid content (TFC) was highest in methanol extract of J. adhatoda leaves (13.030 mg QE/g extract) while T. cardifolia had lower values (2.112 mg QE/g extract) which were determined by taking quercetin as a standard. The result revealed that the TPC is higher in T. cordifolia and TFC value higher in J. adhatoda and that can be correlated with the antimicrobial and antioxidant properties of phytoconstituents although the plants have been used for the similar ethnomedical purpose in society.
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Sharma R. K. and Gandhi A. "Attenuating Effect of Vitamin E and Tinospora cordifolia on Bisphenol-A Induced Apoptosis in Goat Testis." International Journal of Research in Pharmaceutical Sciences 12, no. 2 (June 24, 2021): 1659–66. http://dx.doi.org/10.26452/ijrps.v12i2.4760.
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During the present study effect of Vitamin E and Tinospora cordifolia on BPA induced goat (Capra hircus) testicular tissue was evaluated. Testicular tissue was exposed to varied concentrations of BPA, Vitamin E and Tinospora cordifolia in three experimental groups along with their specific control for 4 and 8hrs. In group I, the cultured tissue was exposed to three doses of Bisphenol-A viz. 0.01, 1.0 and 100 nM/ml. In group II, Vitamin E (0.1µM/ml) was supplemented along with BPA (0.01, 1.0, 100 nM/ml) and in group III Tinospora cordifolia extract (250 µg/ml) was added with BPA (0.01, 1.0, 100 nM/ml) in the culture media. With the increase in dose level as well as the exposure duration, the frequency of apoptotic cells increased significantly (p< 0.05), as revealed by acridine orange and methylene blue staining. BPA exposure also induced a decline in the antioxidant enzyme activity such as catalase, glutathione peroxidase and reduced glutathione. Vitamin E and Tinospora cordifolia resulted in a decrease in the percentage of apoptotic cells and an increase in levels of catalase, glutathione peroxidase and reduced glutathione activity was observed. Hence, it is concluded that BPA induced more damage at its higher concentration and the antioxidant Vitamin E and Tinospora cordifolia ameliorate the oxidative stress-induced changes, thereby suggesting the potential of Vitamin E and Tinospora cordifolia in counteracting the cellular damage induced by agents like BPA.
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Joy, Anu, Harisha C. R, and Acharya R. N. "Micrometric evaluation of two botanical source plants of Guduchi i.e. Tinospora cordifolia (Wild.) Miers and Tinospora malabarica (Lam.) Hook. f. & Thomson stem and leaf." International Journal of Ayurvedic Medicine 12, no. 2 (June 17, 2021): 219–25. http://dx.doi.org/10.47552/ijam.v12i3.1881.
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Background: Guduchi, also known as an Amrita, is one of the important medicinal plants used in Ayurveda. Though Tinospora cordifolia (Wild.) Miers, considered as the official botanical source plant of Guduchi other two species such as Tinospora malabarica (Lam.) Hook. f. &Thomson and Tinospora crispa (L.) Hook. f. & Thomson are also used as a source plant in different parts of India. Though it looks very similar in morphological characters, the micrometric differentiation of two species that is T. cordifolia and T. malabarica are still lacking. Aim: To differentiate the two species of Tinospora through micrometric analysis. Materials and methods: This study portrays both authenticate fresh stem and leaf and with their powdered samples standard histochemical materials, and other laboratory equipment. Result: T. cordifolia and T. malabarica are deciduous woody climbers. The Habitats of both plants are different. T. cordifolia having more prominent lenticels than that of T. malabarica. Main differentiating feature present in the leaf is the presence of trichomes. Most abundant uniseriate trichomes are present in T. malabarica. Trichomes are absent in T. cordifolia. Conclusion: Present data may encourage researchers to use the various dimensions of the research to flourish the different species of Guduchi.
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NEVE, TEJASVINI, Vijaya Vichare, Snehal Sutar, Manasi Rokade, and Shashikant Dhole. "Cytotoxicity Testing of Tinospora cordifolia Extracts against Human Kidney Cancer Cell Line." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 5 (October 1, 2022): 6140–46. http://dx.doi.org/10.37285/ijpsn.2022.15.5.5.
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Background: Anti-cancer effects of medicinal plant products are mentioned in the ancient texts of Ayurveda. Currently, they have been studied at experimental and clinical levels in reverse pharmacology mode. Tinospora cordifolia wild is the most widely used for its medicinal properties in Ayurveda. It has been reported for having anticancer potential in many cancers.
Aim: The aim of the study is to explore the anticancer potential of Tinospora cordifolia Wild extracts against human kidney cancer cell lines.
Materials and Methods: Methanolic extracts leaf and stem of Tinospora cordifolia were obtained by soxhlet extraction. Both the extracts were analyzed for phytochemical screening. Both the extracts along with marker berberine were assessed for their cytotoxicity using the sulforhodamine B assay method against a 786-O human renal cell carcinoma cell line. Statistical analysis was done by Two way (ANOVA) followed by Bonferroni’s Post hoc test.
Results: Tinospora Cordifolia leaf and stem extracts and berberine showed highly significant cytotoxic activity as compared to control.
Conclusion: Therefore, Tinospora cordifolia can be considered as a potential medicinal plant with anticancer activity against human kidney cancer.
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Wisudawan, Andi Sitti Fahirah Arsal, Achmad Imron, Aryanti Bamahry, and Armanto Makmun. "Uji Efektivitas Daya Hambat Ekstrak Daun Binahong terhadap Pertumbuhan Candida Albicans." Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran 1, no. 2 (November 30, 2021): 144–51. http://dx.doi.org/10.33096/fmj.v1i2.153.
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Jamur adalah eukariota heterotrofik yang ada dimana-mana, tahan terhadap lingkungan dan beradaptasi dengan lingkungan yang beragam. Yang paling patogen penting manusia adalah ragi dan jamur. Invasif jamur telah muncul sebagai morbiditas dan mortalitas pada pasien bedah rawat inap. Salah satu jenis jamur ialah Candida albicans dimana spesies Candida yang paling sering terlibat dalam infeksi manusia. Daun binahong (Anredera Cordifolia Tenore Steenis) mengandung banyak zat aktif, diantaranya adalah saponin, alkaloid, polifenol, dan flavonoid yang terbukti memiliki aktivitas antifungi. Mengetahui efektivitas ekstrak daun binahong (Anredera Cordifolia Tenore Steenis) terhadap pertumbuhan Candida Albicans. Penelitian yang dilakukan adalah penelitian experimental post test dengan menggunakan metode disc diffusion. Penelitian ini dilakukan di Laboratorium Penelitian FK-UMI dengan sampel Candida Albicans dan ekstrak daun binahong (Anredera Cordifolia Tenore Steenis) dengan konsentrasi 75% dan 100%. Hasil penelitian ini menunjukkan bahwa pada ekstrak daun binahong (Anredera Cordifolia Tenore Steenis) konsentrasi 75%, tidak terbentuk zona hambat dengan interpretasi resisten. Pada konsentrasi 100%, tidak terbentuk zona hambat dengan interpretasi resisten. Pada Kontrol Positif yang digunakan Ketokonazol terbentuk zona hambat sebesar 25 mm dengan interpretasi sensitif. Ekstrak Daun Binahong (Anredera Cordifolia Tenore Steenis) tidak efektif sebagai agen antifungi terhadap Candida Albicans
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Patil, Rupali, Mahalaxmi Mohan, Veena Kasture, and Sanjay Kasture. "Rubia cordifolia: a review." Oriental Pharmacy and Experimental Medicine 9, no. 1 (March 31, 2009): 1–13. http://dx.doi.org/10.3742/opem.2009.9.1.001.
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Gutiérrez, Alicia B., Juan Carlos Oberti, Virginia E. Sosa, and Werner Herz. "Melampolides from Mikania cordifolia." Phytochemistry 26, no. 8 (January 1987): 2315–20. http://dx.doi.org/10.1016/s0031-9422(00)84710-x.
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Zdero, C., and F. Bohlmann. "Germacranolides from Gutenbergia cordifolia." Phytochemistry 29, no. 8 (January 1990): 2706–8. http://dx.doi.org/10.1016/0031-9422(90)85222-2.
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Balkrishna, Acharya, Ashwani Kumar, Akansha Rohela, Vedpriya Arya, Ajay Kumar Gautam, Hemant Sharma, Priyanka Rai, Amita Kumari, and Ryszard Amarowicz. "Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review." Journal of Pharmacy and Pharmacology, January 27, 2024. http://dx.doi.org/10.1093/jpp/rgae013.
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Abstract Objectives Despite significant advancements in modern medicine, effective hepatoprotective medication with minimal side effects is still lacking. In this context. Tinospora cordifolia, an Indian Ayurvedic liana, has attracted much attention. Key findings Traditionally, T. cordifolia has been found to be effective in the treatment of jaundice; according to the literature, T. cordifolia is a hepatoprotective agent, and the CCl4 model is the most frequently used to evaluate its potential. Its hepatoprotective effects might be attributed to alkaloids (berberine, palmatine, and jatrorrhizine) and sinapic acid. Berberine decreases inflammation by inhibiting the proinflammatory cascade triggered by TNF-α and reduces nitrosative stress by inhibiting iNOS. T. cordifolia also exhibits anticancer, anti-inflammatory, antimicrobial, antioxidant, and other activities; it is safe at concentrations up to 2000 mg/kg. Its biological action can be attributed to polyphenols, alkaloids, steroids, terpenoids, and glycosides. T. cordifolia has also been found to be an active ingredient in several polyherbal formulations used to treat chemical-mediated hepatotoxicity. Conclusion T. cordifolia’s hepatoprotective effects are mediated by the inhibition of lipid peroxidation, the management of oxidative stress, and other factors. T. cordifolia can be used to manage liver disorders and as a hepatoprotective supplement in the food industry. The bioprospecting of its alkaloids can lead to the development of novel formulations against hepatic ailments.
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"Sida-cordifolia." Reactions Weekly 1856, no. 1 (May 2021): 360. http://dx.doi.org/10.1007/s40278-021-96353-9.
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