Relevant bibliographies by topics / Copper in the body

Academic literature on the topic 'Copper in the body'

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Published: 4 June 2021
Last updated: 27 July 2024

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Journal articles on the topic "Copper in the body"

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Doctor, Mariya Bashir, Deepika C Parameswarappa, Pravin Krishna Vaddavalli, and Padmaja Kumari Rani. "Intralenticular copper foreign body." BMJ Case Reports 13, no. 12 (December 2020): e240757. http://dx.doi.org/10.1136/bcr-2020-240757.

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Turnlund, J. R. "Human whole-body copper metabolism." American Journal of Clinical Nutrition 67, no. 5 (May 1998): 960S—964S. http://dx.doi.org/10.1093/ajcn/67.5.960s.

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Twomey, Patrick J. "Raised serum copper results does not mean excess body copper." Journal of Trace Elements in Medicine and Biology 21, no. 2 (June 2007): 141. http://dx.doi.org/10.1016/j.jtemb.2007.03.004.

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Liu, Hua Li, Fei Gao, Wan Hua Nong, and Rong Fu. "Effect of Incremental Copper Powders Third Body on Friction Properties of Q235 Steel." Applied Mechanics and Materials 148-149 (December 2011): 1567–71. http://dx.doi.org/10.4028/www.scientific.net/amm.148-149.1567.

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To understand the effects of the third body of copper in the copper-based composite materials on the friction properties, the effect of copper powders on the friction properties of Q235 steel is studied by using the pin-on-disk tester and adding copper powders third body. The results show that when the friction speed at 500-3000 r/min, due to the incremental copper powders, the depth of the furrows on the friction surface was reduced and the adhesion and spalling process of surface third body were intensified, which results that the frictional coefficients of the Q235 steel are increased 0.2-0.35 comparing with that of without adding copper powders. The reason is that incremental copper third body plays the role of increasing the meshing of the asperity and the actual friction area.
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Focarelli, Francesca, Andrea Giachino, and Kevin John Waldron. "Copper microenvironments in the human body define patterns of copper adaptation in pathogenic bacteria." PLOS Pathogens 18, no. 7 (July 21, 2022): e1010617. http://dx.doi.org/10.1371/journal.ppat.1010617.

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Copper is an essential micronutrient for most organisms that is required as a cofactor for crucial copper-dependent enzymes encoded by both prokaryotes and eukaryotes. Evidence accumulated over several decades has shown that copper plays important roles in the function of the mammalian immune system. Copper accumulates at sites of infection, including the gastrointestinal and respiratory tracts and in blood and urine, and its antibacterial toxicity is directly leveraged by phagocytic cells to kill pathogens. Copper-deficient animals are more susceptible to infection, whereas those fed copper-rich diets are more resistant. As a result, copper resistance genes are important virulence factors for bacterial pathogens, enabling them to detoxify the copper insult while maintaining copper supply to their essential cuproenzymes. Here, we describe the accumulated evidence for the varied roles of copper in the mammalian response to infections, demonstrating that this metal has numerous direct and indirect effects on immune function. We further illustrate the multifaceted response of pathogenic bacteria to the elevated copper concentrations that they experience when invading the host, describing both conserved and species-specific adaptations to copper toxicity. Together, these observations demonstrate the roles of copper at the host–pathogen interface and illustrate why bacterial copper detoxification systems can be viable targets for the future development of novel antibiotic drug development programs.
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Zhou, M., S. J. Wu, X. H. Tan, Q. X. Sun, X. C. Li, Y. W. Dong, C. H. You, and Y. H. Huang. "Growth performance and dynamic copper accumulation in tissues of black soldier fly (Hermetia illucens) larvae under copper exposure." Journal of Insects as Food and Feed 9, no. 12 (October 24, 2023): 1655–61. http://dx.doi.org/10.1163/23524588-20230020.

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Abstract To figure out the copper metabolism features in vivo and evaluate the potential risk of copper residue in tissues of black soldier fly larvae (BSFL) and their by-products, the effects of oral copper exposure of 0, 50, 500 and 1000 mg/kg (Control, Cu50, Cu500 and Cu1000) on growth performance and dynamic copper accumulation in the fat body, cuticle of BSFL and the rearing residue were investigated in a 12-days rearing trial. The results showed that, the body weight and length, and body protein content of BSFL were improved by exposure to 50 mg/kg copper, but reduced by exposure to 500 and 1000 mg/kg copper, as well as that of the pre-pupa rate. Under the copper exposure of 500 and 1000 mg/kg, the copper concentrations in the larval fat body were high at the early developmental stage, but sharply reduced to be 8.1 ± 0.3 mg/kg within 12 days with no significant differences among groups. Similarly, the copper concentrations in the cuticle also decreased rapidly to be 46.3 ± 2.9 and 91.3 ± 9.4 mg/kg in the Cu500 and Cu1000 groups within 12 days, but they were significantly higher than those of the control (8.1 ± 0.3 mg/kg) and Cu50 (10.1 ± 1.1 mg/kg) groups. The linear regression analysis between copper exposure doses and copper concentrations in the rearing residues indicated that the latter are dose- and time-dependent. Overall, the growth performance and body protein content of BSFL were improved by low copper exposure, but reduced by high copper exposure. The oral copper could be excluded from larval fat body and cuticle rapidly, and be largely accumulated in the rearing residues. Therefore, little risk of copper residue in the main tissues of post larvae or pre-pupae of black soldier fly (BSF), but higher risk of it in the rearing residues could be anticipated. Our results provide valuable information for safety assessment of copper residues in BSF products and by-products.
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Borgmann, U., and W. P. Norwood. "Toxicity and accumulation of zinc and copper in Hyalella azteca exposed to metal-spiked sediments." Canadian Journal of Fisheries and Aquatic Sciences 54, no. 5 (May 1, 1997): 1046–54. http://dx.doi.org/10.1139/f97-020.

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The relationship between zinc and copper toxicity in Hyalella azteca and accumulation from metal-spiked sediments was determined for future use in identifying sites where these metals contribute to sediment toxicity. Both zinc and copper accumulation increased rapidly with increasing sediment concentrations, showing no evidence of saturation as seen in waterborne exposures. Zinc accumulation from zinc spiked sediments was substantial, even at concentrations below those causing chronic toxicity, and body concentrations can readily be used to infer chronic toxicity. Chronic toxicity in spiked sediment exposures occurred at excess (above background) body concentrations twice as high as in waterborne exposures, possibly as a result of zinc in gut contents. In contrast, chronic copper toxicity occurred at body concentrations lower than those observed in waterborne exposures. Furthermore, body copper at low sediment exposures was independent of copper in sediment. Body copper concentrations can be used to infer short-term (1-week) toxicity but not chronic toxicity. Copper, but not zinc, caused a reduction in growth, even at concentrations below the 4-week LC25. Reduced growth can, therefore, be used to differentiate between chronic copper and zinc toxicity in sediments.
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Li, H., S. C. Wu, D. Tian, J. Quinn, Y. S. Li, F. Jona, and P. M. Marcus. "Epitaxial growth of body-centered-tetragonal copper." Physical Review B 40, no. 8 (September 15, 1989): 5841–44. http://dx.doi.org/10.1103/physrevb.40.5841.

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Billi, B., G. Lesnoni, C. Scassa, M. A. Giuliano, A. M. Coppè, and T. Rossi. "Copper Intraocular Foreign Body: Diagnosis and Treatment." European Journal of Ophthalmology 5, no. 4 (October 1995): 235–39. http://dx.doi.org/10.1177/112067219500500407.

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Li, H., S. C. Wu, J. Quinn, Y. S. Li, D. Tian, and F. Jona. "Electronic properties of body-centred-tetragonal copper." Journal of Physics: Condensed Matter 3, no. 37 (September 16, 1991): 7193–98. http://dx.doi.org/10.1088/0953-8984/3/37/011.

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Dissertations / Theses on the topic "Copper in the body"

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Fulcher, Yan G. "Functional studies of hCTR1, a high affinity human copper and cisplatin transporter." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6048.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on June 19, 2009) Includes bibliographical references.
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Iskandar, Monica. "Elevated levels of dietary zinc intake modulate the expression of CCS and intestinal zinc trafficking proteins." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84041.

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Experiments were carried out to examine the value of CCS (copper chaperone for CuZn superoxide dismutase) as a novel biomarker of zinc-induced mild copper deficiency and to evaluate the changes in expression of zinc transporters in response to graded levels of moderately high dietary zinc. Weanling male Wistar rats were fed graded levels of zinc (30, 60, 120 and 240 mg zinc/kg diet) for 5 weeks. Results showed a dose-dependent decrease in copper content and an increase in CCS expression in tissues of rats fed the Zn-60 and Zn-120 diets. Surprisingly, rats fed the Zn-240 diet showed better copper status than rats fed the Zn-120 diet. Expression of zinc transporters was significantly upregulated in the small intestine of Zn-240 rats. Collectively, these data show that CCS is responsive to zinc-induced mild copper deficiency, and can serve as a sensitive biomarker of mild copper deficiency. The increased expression of intestinal zinc transporters expression may account for the better copper status of Zn-240 rats.
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Kinsman, George David. "The assessment of body copper status and its application to the study of atherosclerosis." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239197.

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Ke, Ying, and n/a. "Mechanisms by which COMMD1 down-regulates Epithelial Sodium Channel (ENaC) activity." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081205.161914.

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The epithelial sodium channel (ENaC) made up of α, β and γ subunits is located at the apical membrane of polarised epithelia and mediates transport of sodium ions into the cells. Tight control of ENaC function is essential for maintaining sodium homeostasis, blood volume and blood pressure. Controlling the number of active channels present at the cell surface appears to be critically important in regulating ENaC activity. The neural precursor cell expressed developmentally down-regulated gene 4 (Nedd4) family of proteins (eg. Nedd4-2) ubiquitinate ENaC and decrease its cell surface expression. The activity of Nedd4-2 is modulated by serum and glucocorticoid-induced kinase (SGK), which phosphorylates Nedd4-2 and increases cell surface expression of ENaC. The c̲o̲pper m̲etabolism gene M̲URR1 d̲omain 1 (COMMD1) protein is a recently identified ENaC binding partner and negative regulator of channel activity. Studies by other groups suggest that COMMD1 is also involved in the processes of intracellular protein trafficking and ubiquitin-dependent protein degradation. The aims of this study were 1). To characterise the interactions between COMMD1 and ENaC. 2). To identify the mechanism(s) by which COMMD1 down-regulates ENaC activity. Here protein-protein interaction studies were used to show that a recently identified conserved C-terminal domain (the COMM domain) in COMMD1 is essential for its binding to ENaC. The binding site for COMMD1 in βENaC was found to be located in its N-terminal domain. COMMD1 was shown to down-regulate ENaC by increasing ubiquitin modification of ENaC and by decreasing the cell surface population. COMMD1 was found to interact with SGK and formed a complex with SGK and Nedd4-2. Ussing chamber studies of Na⁺ transport showed that COMMD1 attenuated the stimulation of ENaC by SGK and abolished insulin-stimulated ENaC current in epithelial cells. Conversely, knock-down of COMMD1 increased ENaC current in mammalian epithelial cells. These data suggest that COMMD1 plays a role in regulating ENaC activity in epithelial cells and its effect is likely mediated via SGK. In addition COMMD1 was found to bind to the adaptor protein subunit [mu]2. Mutations in COMMD1 that disrupt its interaction with [mu]2 impair its ability to decrease cell surface expression of ENaC in Cos-7 cells, therefore COMMD1 may also have a role in the endocytosis of ENaC by linking cell surface ENaC to the clathrin-dependent endocytosis machinery. In summary, this study investigated the interactions between COMMD1 and ENaC and identified that the SGK/Nedd4-2 pathway is involved in the COMMD1-mediated ubiquitination and down-regulation of ENaC activity.
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Hoogeveen, Cornelis Adrianus Johannes Maria. "Hepatic apolipoprotein A-I synthesis andmRNA abundance, and whole body energy metabolism in copper-deficient rats." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186449.

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The influence of dietary copper deficiency on hepatic apolipoprotein A-I synthesis and mRNA abundance, as well as on whole body energy metabolism was examined in rats. Weanling male Sprague-Dawley rats were divided into two dietary treatments; copper-adequate (6.0 mg Cu/kg diet) and copper-deficient (0.6 mg Cu/kg diet). After 6 weeks of treatment, an increase in intravascular apolipoprotein A-I pool size was observed in copper-deficient rats. In part I, in vivo hepatic apolipoprotein A-I synthesis was determined by the injection of flooding dose of [³H]phenylalanine and measurement of the incorporation of [³H]phenylalanine into newly synthesized immunoprecipitable apolipoprotein A-I in liver homogenates as well as plasma. A pulse-chase study was designed using [³H]phenylalanine, to determine the in vitro hepatic apolipoprotein A-I synthesis and intracellular degradation in freshly isolated hepatocytes. Furthermore, hepatic apolipoprotein A-I mRNA abundance was determined by dot blot analysis. In part II, rats were individually housed in metabolic cages within indirect calorimetry units to study their energy metabolism. Total body composition was determined by total body electrical conductivity. Copper deficiency resulted in a specific 2-fold increase in hepatic apolipoprotein A-I synthesis and secretion. In vitro hepatic intracellular degradation was small and not affected by copper status. The hepatic apolipoprotein A-I mRNA abundance was increased by 28% when corrected for liver-to-body weight ratio in the copper-deficient rats. Copper deficiency resulted in a distinct shift in energy substrate utilization from carbohydrate to fat. Body weight gain and net energy retention were reduced as a result of copper deficiency. Total body composition analysis showed a reduction in percent fat mass in the copper-deficient rats. The present data suggest that copper deficiency results in an increased cellular demand for lipids as energy substrate in order to maintain an adequate energy balance. The observed increase in hepatic apo A-I synthesis may be a result of an increased demand for HDL formation to sustain an increased flux of lipid substrates between the liver and peripheral tissues, resulting in the observed hypercholesterolemia in copper-deficient rats.
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Tore, Micaela Ann. "Beyond Materiality: The Self and the Malleable Body in Alyse Knorr's Copper Mother and Dalton Day's Exit, Pursued." Bowling Green State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1558455170150697.

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Zhang, Jin 1960. "The influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cells." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276935.

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This study was designed to examine the influence of Cu deficiency on the binding, uptake, and degradation of apolipoprotein E-free high density lipoproteins (apo E-free HDL) in cultured rat hepatic parenchymal cells. The binding of apo E-free HDL during time course studies was slightly but significantly increased in cells derived from Cu-deficient rats. In saturation studies, the amount of surface-bound apo E-free HDL appeared to be saturable, although no difference was observed between Cu-deficient and adequate animals. The amount of total and specific cell-associated uptake of apo E-free HDL was significantly increased in hepatic parenchymal cells of Cu-deficient animals. The present data suggest that hepatic uptake of the HDL protein moiety may be increased in rats fed a diet deficient in copper.
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Monasterios, Clevys Josefina. "Determination of copper and zinc at trace levels in human hair using a direct sample insertion technique for inductively coupled plasma atomic emission spectrometry." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63251.

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Morgan, M. Thomas. "Molecular tools for elucidating copper biochemistry: Water-soluble fluorescent probes and robust affinity standards." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/51937.

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Copper is an essential trace element for living organisms and has both known and additional suspected roles in human health and disease. The current understanding of copper metabolism is substantial but incomplete, particularly in regard to storage and exchange at the subcellular level, although available evidence indicates exchangeable intracellular copper is in the monovalent oxidation state. Selective fluorescent probes with sufficient sensitivity to detect Cu(I) availability at physiologically relevant levels and at subcellular resolution would be valuable tools for studying copper metabolism. As a contribution toward this goal, this work describes the development of Cu(I)-selective fluorescent probes with greatly improved aqueous solubility, contrast ratio, and fluorescence quantum yield. This work also describes the development of water-soluble, 1:1-binding chelators that form colorless, air-stable copper(I)-complexes. By acting as copper(I) buffering agents and affinity standards, these compounds can serve a complementary role to fluorescent probes in the study of copper biochemistry.
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Ashurian, Nicole. "Bodyscapes : body to body, body to city, body to self." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118683.

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Thesis: M. Arch., Massachusetts Institute of Technology, Department of Architecture, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 106-107).
Our modern spaces are a result of a history of architects losing agency to technology. In the era of climate control spaces and the digital interfaces of social media, a sense of place and association with others is lost to enclosed spaces of satellite conversations detailed with attention to standardization rather than customization. These desires for comfort and control manifest in the lack of friction in our built realm. Spaces mirror the scaleless quality of the digital, impose no physical friction of environment and allow for isolation between bodies in the same room. Boarded in these spaces with the disappearing digital threshold, our friends fall in the same political silos as ourselves, empathy for others falters, context is arbitrary and we never have to be 'alone' when we have our phones. The tech industry tries to offer solutions to alleviate these problems with apps and devices. However, without a violent change in environment - engaging the physicality of the body, its senses and its association to others and site, the problems will persist. 'Bodyscapes' is a series of provocations at varying scales that subvert the language of corporate standardization to allow new opportunities for human interface where the public and private realm meet.
by Nicole Ashurian.
M. Arch.
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Books on the topic "Copper in the body"

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McC, Howell J., and Gawthorne J. M, eds. Copper in animals and man. Boca Raton, Fla: CRC Press, 1987.

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Matović, Vesna. Zinc, copper, or magnesium supplementation against cadmium toxicity. Hauppauge, N.Y: Nova Science, 2010.

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Matović, Vesna. Zinc, copper, or magnesium supplementation against cadmium toxicity. New York: Nova Science, 2010.

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Hinchcliffe, M. T. The Effect of sub-lethal doses of copper on the whole copper body loads and growth rates in the freshwater shrimp,Gammarus pulex (Crustacea: Amphipoda). Wolverhampton: University of Wolverhampton, 1994.

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Upchurch, Nancy J. Handbook of Tea Leaf body styles: A compendium of body styles decorated with traditional and variant Tea Leaf motifs and copper lustre treatments. [S.l.]: Tea Leaf Club International, 1995.

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Kwak, Hŭi-sang. Chʻilge ŭi toksŏng mulchil chʻukchŏk: Kʻadŭmyum chʻukchŏk e ttarŭn kapkok kwa kŭnyuk ŭi kuri hamnyang pyŏnhwa = On the Cadmiun bioaccumulation by the crab microphthalmus (mareotis) japonicus De Haan : variations of the copper contents in the carapaces and muscles of the crabs in relation to the Cadmium bioaccumulation. [Seoul]: Hanʼguk Kwahak Kisurwŏn, Haeyang Yŏnʼguso, 1987.

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1688-1752, Cheselden William, ed. The anatomy of the humane body: Illustrated with twenty-three copper-plates of the most considerable parts; all done after the life. Birmingham, Ala.]: [Classics of Surgery Library], 1985.

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Telehin, D. I͡A. Kam'i͡ani "bohy" Midnoho viku Ukraïny: Dopovidʹ, prochytana avtoramy na Miz͡hnarodniĭ konferent͡siï "Kam'i͡ani bohy I͡Evropy" v m. Aosta, Italii͡a, 1998 r. = Stone "gods" of the Copper age in Ukraine. Kyïv: Ukraïnsʹke t-vo okhorony pam'i͡atok istoriï ta kulʹtury, Sekt͡sii͡a arkheolohiï, 1998.

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Spindler, Konrad. The man in the ice: The preserved body of a Neolithic man reveals the secrets of the Stone Age. London: Weidenfeld and Nicolson, 1994.

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Spindler, Konrad. The man in the ice: The discovery of a 5,000-year-old body reveals the secrets of the stone age. Toronto: Doubleday Canada, 1994.

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Book chapters on the topic "Copper in the body"

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Mielcarz, G. "Copper Body Status and Cardiovascular Diseases." In Trace Elements in Man and Animals 10, 573. New York, NY: Springer US, 2002. http://dx.doi.org/10.1007/0-306-47466-2_185.

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Aharony, Amnon. "Magnetism and Superconductivity in Doped Lamellar Copper Oxide Systems." In Recent Progress in Many-Body Theories, 33–34. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4615-3798-4_4.

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Ruksan, B. E., M. Correa Luna, and F. Lagos. "Effect of Oral Copper Needles and Parenteral Copper on Hypocupraemia, Body Weight Gain and Fertility in Cattle." In Trace Elements in Man and Animals 6, 653–56. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0723-5_238.

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Belinicher, V. I., A. L. Chernyshev, and L. V. Popovich. "Consistent Low-Energy Reduction of the Three-Band Model for Electrons and Holes in Copper Oxides to the Effective t - J Model." In Recent Progress in Many-Body Theories, 443–48. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1937-9_39.

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O’Connor, J. M., M. P. Bonham, E. Turley, C. Kehoe, J. S. Coulter, M. S. Faughnan, A. McKeown, et al. "The Effect of Copper Supplementation on Putative Indices of Body Copper Status and on Oxidative and Inflammatory Measures (Foodcue Project)." In Trace Elements in Man and Animals 10, 943–45. New York, NY: Springer US, 2002. http://dx.doi.org/10.1007/0-306-47466-2_295.

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Green, Mark A., Carla J. Mathias, Nathaniel J. Smith, Monica Cheng, and Gary D. Hutchins. "In Vivo Quantitative Whole-Body Perfusion Imaging Using Radiolabeled Copper(II) Bis(Thiosemicarbazone) Complexes and Positron Emission Tomography (PET)." In Methods in Molecular Biology, 751–71. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1803-5_40.

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Marković, Zoran M., and Biljana M. Todorović Marković. "Novel Antimicrobial Strategies to Combat Biomaterial Infections." In Urinary Stents, 305–13. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04484-7_24.

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AbstractBacteria are present in nature everywhere and the combat with them has the major priority especially in various industrial settings (i.e. food industry) or medical devices. It was established earlier that most of bacteria found in nature exist in the form of biofilms (attached to surface of different objects and not as free floating organisms).There are several possible strategies to reduce or prevent bacterial infections among different populations: patients and medical staff. One of the alternative strategies independent of human labor, is to produce antibacterial coatings to reduce or eliminate bacteria colonization on surfaces by leaching of biocides, antibacterial surfaces with deposited metals such as copper, silver or gold, formation of superhydrophobic surfaces and surfaces encapsulated by photoactive nanoparticles.A new light triggered strategies to combat bacterial infections and possible usage of photoactive polymers for these purposes. Photoactive antibacterial polymers are highly promising solution for novel medical devices. To enable their wise usage for the treatment of urinary infections some changes must be made. For example, the effectiveness of photoactive polymers inside human body can be increased by incorporation of micron sized electronic devices (light emitting diode, light detector, pH sensor, radio frequent device) into polymer matrices.
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Thakur, Mathew L. "Can VPAC-Targeted Cu-67-TP3805 Play a Theranostic Role for Prostate Cancer?: A Quest." In Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum, 321–30. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-33533-4_32.

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AbstractEarly and accurate detection of prostate cancer (PCa) together with effective treatment can save lives. Despite the recent advances in its treatment, the mortality trends due to PCa, in the USA, continue to be alarming with annual increase of 3%. In this brief communication, we propose a novel approach to treat PCa, its metastasis and recurrence. This is guided by a large quantity of preliminary data driven by targeting an endogenous genetic product, VPAC, expressed in high density on the cell surface at the onset of genetic mutation that ignites the cancerous transformation.A large body of preclinical and clinical data generated in our laboratory used a positron-emitting radionuclide Copper-64 (Cu-64), conjugated to a small biomolecule, TP 3805 that has a high in vivo stability and high affinity (Kd 3.1 × 10−9 M) for VPAC. The data depict high uptake of Cu-64-TP3805 in primary and metastatic lesions and malignant lymph nodes with minimal uptake in normal tissues except the liver, prompted by the hepatobiliary excretion.Reflecting on the present and planning for the future, our quest is to systematically investigate the use of the beta-emitting sister radionuclide Cu-67 to target VPAC receptors for theranostic applications of primary and metastatic PCa.
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Ranimol, G., C. B. Devipriya, and Swetha Sunkar. "Docking and Molecular Dynamics Simulation Studies for the Evaluation of Laccase Mediated Biodegradation of Triclosan." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 205–13. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_20.

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AbstractTriclosan (TCA) is an antibacterial and antimicrobial compound that is incorporated into toothpaste, soap, and liquid dishwasher. Continuous TCA exposure may contribute to the emergence of antibiotic-resistant bacteria in the microbiome. Triclosan also reacts to form dioxins, which bioaccumulate and are toxic to aquatic organisms, impedes the thyroid hormone metabolism of the human body. Laccases are multi copper-containing enzymes that can degrade the aromatic compounds and thus reduce their toxicity. To effectively degrade the compound, it is essential to understand the molecular function of the enzyme. Hence, a molecular docking study of laccase enzymes with Triclosan was done. The Tramates versicolor laccase structure was retrieved from PDB and ligand structure was taken from Pubchem. The binding mode and interaction of TCA and laccase were studied using Auto dock Vina software and the stability of the docked complex had been explored via Molecular Dynamics (MD) simulation study using Schrodinger Desmonde. The binding affinity score was found to be −6.5kcal/mol. The majority of the residues in RMSF were within the 2.5Å limit. The radius of gyration remained within the range from 21.7 to 22.1Å for Laccase – TCA complex throughout the 50 ns simulation. MD simulation results show that the enzyme complex remains stable all through the catalytic action.
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Sevasti, Despina. "The Cornucopia of Greekness: Copies and Performances of a Body That Never Was." In Political and Cultural Aspects of Greek Exoticism, 125–38. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-19864-0_10.

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Conference papers on the topic "Copper in the body"

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Bonny, Giovanni, Roberto C. Pasianot, Nicolas Castin, Dmitry Terentyev, and Lorenzo Malerba. "Iron-Copper-Nickel Many-Body Potential Consistent With Thermodynamics." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75619.

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The Fe-Cu-Ni ternary alloy is of interest for nuclear applications because Cu and Ni are considered to have major effects on the embrittlement under irradiation of reactor pressure vessel steels. To improve our understanding on this phenomenon, large scale atomistic simulations in this model alloy are desirable. For this purpose we develop a ternary Fe-Cu-Ni many-body potential consistent with thermodynamics is developed for the first time. The potential was validated using molecular static and atomistic kinetic Monte Carlo simulations and a qualitative agreement with experiments was established. In particular, Cu precipitates were found to be enriched by Ni on the precipitate surface. Also, the effects diluting the Fe-Cu alloy by Ni on mean precipitate size and density showed similar trends as observed in experiments; i.e. no effect of Ni on the mean precipitate size and an increase in the maximum precipitate density due to the addition of Ni. In absolute terms, agreement with experiment is poor due to the limited box size used in the simulations, as correspondingly discussed.
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Sano, Toru, Yukiyasu Shiroi, Yoshimitsu Fukui, and Shigeru Usuda. "Development of Anti-Corrosion Steel Sheet Containing Copper for Automobile Body Parts." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1994. http://dx.doi.org/10.4271/940538.

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Gupta, Jegyasu, Priyanka Das, Ratnajit Bhattacharjee, and Debabrata Sikdar. "Flexible Metasurface-Based Wraps for Improving Magnetic Field Enhancement in 1. 5T MRI." In CLEO: Applications and Technology. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/cleo_at.2023.jtu2a.2.

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We design a flexible metasurface comprising interconnected copper spirals on polyimide substrate for boosting radio-frequency magnetic field in the region-of-interest for 1.5T MRI. The ultra-thin, body-conformal structure is implementable as “add-ons” inside body-specific transceiver coils.
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Serafimovski, Todor. "THREE TYPES OF ORE MINERALIZATION AT THE VRSHNIK ORE BODY, BUCHIM COPPER MINE, REPUBLIC OF MACEDONIA." In 16th International Multidisciplinary Scientific GeoConference SGEM2016. Stef92 Technology, 2016. http://dx.doi.org/10.5593/sgem2016/b12/s03.122.

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Serafimovski, Todor. "TECHNO-ECONOMIC PARAMETERS RELATED TO THE VRSHNIK CU-AU ORE BODY, BUCHIM COPPER MINE, EASTERN MACEDONIA." In 14th SGEM GeoConference on SCIENCE AND TECHNOLOGIES IN GEOLOGY, EXPLORATION AND MINING. Stef92 Technology, 2014. http://dx.doi.org/10.5593/sgem2014/b13/s3.080.

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Su, Linlin, Fei Gao, Hualong Tao, Xiaoming Han, and Rong Fu. "Influence of third body evolution on tribological property of copper-matrix friction material by surface treatment." In MATERIALS SCIENCE, ENERGY TECHNOLOGY, AND POWER ENGINEERING I: 1st International Conference on Materials Science, Energy Technology, Power Engineering (MEP 2017). Author(s), 2017. http://dx.doi.org/10.1063/1.4982366.

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Payton, Lewis N. "Orthogonal Machining of Copper Alloy With a Hardness Gradient." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-87524.

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An experimental and analytical investigation of the effects of hardness upon the classical orthogonal machining geometries was conducted using copper alloy with 12 levels of hardness as measured on the Brinell hardness scale. A real time data collection method permitted the collection of a large body of data for analysis. 720 experimental runs were analyzed. The experimental results were compared to thirteen geometrical models that have been formulated including Merchant’s and Piispanen’s independently derived orthogonal machining equations of the 1940’s. One model [1] was verified by the results of the experiment in copper when a regression study of the data was conducted. Their application of the minimum energy principle in deriving an expression for the shear front angle ψ, the onset of shear plane angle ϕ, and the tool face rake angle α, provided an accurate shear strain model that is well supported by the physical evidence. The resulting relationship: ψ=45°-φ+α2 is predictive. It correlates directly and strongly with the measured material hardness.
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Hwang, Shun-Fa, Zheng-Han Hong, and Te-Hua Fang. "Molecular Dynamics Simulation of Iron Clusters Deposition on Copper Substrate." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-24504.

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A molecular dynamic method was used to simulate the film growth process of ionized cluster beam deposition for Fe clusters depositing on Cu substrate with low energy. The tight-binding many-body potential is used to simulate the interaction between atoms. It will focus on the diverse deposition process parameters including incident energy, and substrate temperature, and it will use atomic stress tensor to obtain the residual stress after the deposition process. During simulations, we will find out the critical value of the incident energy to create epitaxy growth or interfacial intermixing, observe the roughness of epitaxy growth surface to determine the quality of film, and compute the residual stress. From the simulation results, the effects of the deposition process parameters on the morphology of the deposited film could be evaluated.
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Mikheeva, L. A., S. A. Shchelkaev, and A. V. Mikheeva. "Preparation of copper pectate preparation for use in medical practice." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-147-150.

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Currently, the processes of complexation of various ligands, including biopolymers with metals, attract the attention of scientists from different countries not only in order to obtain new data on the methods of synthesis and properties of metal complexes, but also in connection with the search for ways to obtain new effective biologically active drugs among them. Since the life around us is oversaturated with various artificially produced drugs that have a negative effect on the human body, today, more than ever before, the question arises of using natural, environmentally friendly ingredients instead of synthetic ones, for example, such as pectin. The study of the structural parameters and physico-chemical properties of complexes of pectin substances with metals will significantly expand the scope of their practical use. Key words: metal complexes, pectin, copper pectate, complex formation.
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Opanike, Oyetunde, Olugbenga A. Omotosho, Emmanuel O. Akindele, and Omolola O. Yusuf. "Hepatocellular Effect of Copper Poisoning on the Liver and Kidney of Albino Rats (<i>Rattus norvicus</i>)." In 2023 International Conference on Sustainable Engineering and Materials Development. Switzerland: Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-vzg5cj.

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Copper and its salt are remarkably non-toxic to mammalian tissue. It is possible to ingest a large number of soluble copper salts such as copper sulphide to produce intoxication, nausea, vomiting, diarrhoea, and abdominal cramp. Copper salts are widely employed in agriculture and veterinary practice. Copper is an essential trace element in life and is a component of several metalloenzymes and other proteins such as cytochrome oxidase, heamocyanin, lysin oxidase, ascorbate oxidase and amine oxidase. When copper is present in the body above a particular dosage of greater than 100ppm in rats, it becomes fatal to rats. Copper is transported by blood, and is distributed to tissue and organs which have different retention capacities with the highest level of copper found in the liver, kidney, spleen and lungs. This study investigated the toxicological effect of copper in the liver and kidney of animals, using albino rats as the experimental animal. The serum chemistry report showed that the protein value of the liver homogenate for most of the experimental rats was higher than that of the control whereas the value of globulin for the control was similar to that of the experimental rats. The kidney homogenate revealed that Calcium ion has higher contents in the experimental rats than that in the control. In conclusion, the effect of copper varies with the groups of rats as compared to the control.
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Reports on the topic "Copper in the body"

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Gandhi, S. S., and N. Prasad. Geological setting of Bode copper and Damp polymetallic prospects, central Great Bear magmatic zone, Northwest Territories. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1995. http://dx.doi.org/10.4095/202919.

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Corriveau, L., and E. G. Potter. Advancing exploration for iron oxide-copper-gold and affiliated deposits in Canada: context, scientific overview, outcomes, and impacts. Natural Resources Canada/CMSS/Information Management, 2024. http://dx.doi.org/10.4095/332495.

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The Geo-mapping for Energy and Minerals (GEM) and Targeted Geoscience Initiative (TGI) programs conducted extensive collaborative research on mineral systems with iron oxide-copper-gold (IOCG) and affiliated deposits in prospective settings of Canada. Regional alteration mapping as well as geochemical and geophysical modelling undertaken under the GEM program documented the evolution of polymetallic metasomatic systems with iron-oxide and alkali-calcic alteration and led to an increased recognition of the mineral potential of poorly explored areas and historic deposits of the Great Bear magmatic zone in the Northwest Territories, thus providing a solid framework for exploration. Early and barren albitite corridors form across the mineral systems and locally host uranium mineralization associated with telescoping of alteration facies by tectonic activity during the metasomatic growth of the systems. Subsequent to albitization, high-temperature Ca-Fe and Ca-K-Fe alteration form iron oxide-apatite (± rare-earth element) mineralization and IOCG variants rich in cobalt and other critical metals, respectively. Systems that further mature to K-Fe alteration form IOCG mineralization and can evolve to mineralized near-surface phyllic alteration and epithermal caps. Transitional facies also host polymetallic skarn mineralization. Rare-earth element enrichments within iron oxide-apatite zones are strongest where remobilization has occurred, particularly along deformation zones. The TGI projects documented the pertinence for a GEM activity in the Great Bear magmatic zone and subsequently synthesized GEM geoscientific data into a system-scale, ore-deposit model, and outlined criteria for mineral resource assessment. This model, and newly developed field-mapping and lithogeochemical tools were shown to be efficient mineral exploration and regional mapping methods in Canada and were also applied to the archetype IOCG deposit, Olympic Dam, and other deposits in the Olympic Cu-Au metallogenic province of Australia. Case examples also include the Romanet Horst in the Trans-Hudson Orogen (second phase of GEM), the Central Mineral Belt in Labrador (TGI), the Wanapitei Lake district in Ontario (private sector exploration results used by TGI), and the Bondy gneiss complex in Quebec (TGI).
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Guan, Xin, Richard Lance, and Sheena Feist. Environmental DNA (eDNA) assays for the detection of Ridgway’s Rail (Rallus obsoletus) in the United States. Engineer Research and Development Center (U.S.), July 2024. http://dx.doi.org/10.21079/11681/48757.

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We designed two novel environmental DNA (eDNA) assays for the detection of Ridgway’s Rail (Rallus obsoletus), and successfully validated each assay using eDNA samples collected from the species’ known distribution within the United States. These assays add to the suite of tools available for the monitoring of this rare and secretive marsh bird, and may help to further elucidate its movement patterns as well as identify important migration corridors. Observed sensitivity of the assays indicates exceptional performance, with limits of detection at ≤ 8 copies of the target eDNA fragment per reaction. Our publication adds to the growing body of literature supporting eDNA surveys as viable tools for bird monitoring endeavors.
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Champion, Theresa. Studies of Charmless Two-Body, Quasi-Two-Body and Three-Body B Decays. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/784763.

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Pritchard, Joy, H. R. Whay, and A. Brown. Body condition. Brooke, 2011. http://dx.doi.org/10.46746/gaw.2020.abi.bcs.

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Kirkham, R. V., and W. D. Sinclair. Vein copper. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1995. http://dx.doi.org/10.4095/208010.

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Dawson, K. M., and R. V. Kirkham. Skarn copper. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1995. http://dx.doi.org/10.4095/208018.

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Brown, Ashleigh. Firing: body areas. Brooke, April 2011. http://dx.doi.org/10.46746/gaw.2020.abi.firbdar.

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Pritchard, Joy, and H. R. Whay. Body lesions - severity. Brooke, 2011. http://dx.doi.org/10.46746/gaw.2021.abi.les.sev.

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Brown. Body lesions - size. Brooke, 2011. http://dx.doi.org/10.46746/gaw.2020.abi.les.size.

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