Relevant bibliographies by topics / Coombs

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Coombs'

Author: Grafiati
Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Coombs"

1

Rowse, Tim. "Coombs the Keynesian." History of Economics Review 30, no. 1 (January 1999): 108–25. http://dx.doi.org/10.1080/10370196.1999.11733316.

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Matthews, Jennifer, and Susie Newton. "The Coombs Test." Clinical Journal of Oncology Nursing 14, no. 2 (March 29, 2010): 143–45. http://dx.doi.org/10.1188/10.cjon.143-145.

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3

Fye, W. Bruce. "Carey F. Coombs." Clinical Cardiology 15, no. 11 (November 1992): 868–69. http://dx.doi.org/10.1002/clc.4960151115.

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Rowse, Tim. "'The Responsive Public Servant': Coombs the Man, Coombs the Report." Australian Journal of Public Administration 61, no. 1 (March 2002): 99–102. http://dx.doi.org/10.1111/1467-8500.00263.

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N, Bhatnagar. "Evan’s Syndrome - A Case Report." Haematology International Journal 4, no. 2 (2020): 1–3. http://dx.doi.org/10.23880/hij-16000174.

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Evan’s syndrome is a rare and chronic autoimmune disease characterised by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive Coomb’s test in the absence of an underlying etiology. Majority of the patients with this syndrome have a chronic relapsing course and significant morbidity and mortality despite treatment. We present a case of a 22 year old female, in which, based on the clinical features, Coombs test, hemolytic anemia and thrombocytopenia, a diagnosis of Evans syndrome was made.
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Orduña, Antonio, Ana Almaraz, Ana Prado, M. Purificación Gutierrez, Agustina Garcia-Pascual, Ana Dueñas, Milagros Cuervo, et al. "Evaluation of an Immunocapture-Agglutination Test (Brucellacapt) for Serodiagnosis of Human Brucellosis." Journal of Clinical Microbiology 38, no. 11 (2000): 4000–4005. http://dx.doi.org/10.1128/jcm.38.11.4000-4005.2000.

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We evaluated the validity and the usefulness of a new test for the diagnosis of human brucellosis based on an immunocapture-agglutination technique. A total of 315 sera from 82 patients with a diagnosis of brucellosis, 157 sera from patients in whom brucellosis was suspected but not confirmed, and 412 sera from people living in rural areas with endemic brucellosis were studied. The seroagglutination test (SAT), Coombs anti-Brucella test, and Brucellacapt test were evaluated. All the initial sera from the 82 patients proved to be positive in Brucellacapt and Coombs tests, while only 75 (91.4%) were positive in the SAT. If a ≥1/160 diagnostic threshold titer was defined for the Brucellacapt test, Coombs test, and SAT, the sensitivities were 95.1, 91.5, and 65.8%, respectively. Taking the same diagnostic threshold titer for the 157 sera from the unconfirmed but suspected patients, the specificities of the Brucellacapt, Coombs, and SAT were 81.5, 96.2, and 100%, respectively; for the 412 control sera, the specificities were 99.0, 99.8, and 100%. The diagnostic efficiency (area below the receiver operating characteristic curve) of Brucellacapt was 0.987852 (95% confidence interval [CI], 0.95109 to 0.99286), very similar to the diagnostic efficiency of the Coombs test (0.97611; 95% CI, 0.94781 to 0.99146) and higher than that of SAT (0.91013; 95% CI, 0.86649 to 0.94317). The results of the Brucellacapt test were compared with those of the Coombs test (correlation coefficient, 0.956; P= 0.000) and SAT (correlation coefficient, 0.866; P = 0.000). The study shows very good correlation between the Brucellacapt and Coombs tests, with a high concordance between titers obtained in the two tests. Nevertheless, lower correlation and concordance were found between the Brucellacapt and Coombs tests when the results for titers of ≥1/160 were compared (0.692; P = 0.000). In acute brucellosis, the Brucellacapt and Coombs tests render positive titers of ≥1/160. When the titers are lower, they increase significantly in the following 30 days, despite the evolution of SAT titers. In contrast, Brucellacapt and Coombs titers are always high (≥1/640) in brucellosis with long evolution, whether SAT titers are higher or lower than 1/160.
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Kaufman, Matthew S., Yehuda Z. Lebowicz, Nancy Driscoll, Christina Johnson, Dale Janson, Angelica Caramanica, Rajasree Roy, et al. "A Combination of Rituxan, Cyclophosphamide and Dexamethasone (RCD) Results in Long-Lasting Responses in Autoimmune Anemia and Thrombocytopenia in CLL Patients: A Single Institution Study." Blood 108, no. 11 (November 16, 2006): 2832. http://dx.doi.org/10.1182/blood.v108.11.2832.2832.

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Abstract Coombs positive hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) are well-known complications of chronic lymphocytic leukemia(CLL). Both are autoimmune phenomena thought to be byproducts of the immune system dysregulation manifested in patients with CLL. Rituxan, cyclophosphamide and dexamethasone(RCD) are known to effectively target lymphocytes and inhibit autoimmune processes. We present our data analyzing 18 CLL patients with one or both of these autoimmune processes treated with the RCD regimen between 1998 and 3/2006. These patients consisted of 15 with AIHA alone, 2 with both AIHA and ITP and one with ITP alone. The RCD cycle consisted of rituximab 375mg/m2 iv infusion given on day 1, cyclophosphamide 750–1000mg/m2 iv (depending on CLL tumor burden) on day 2, and dexamethasone 12 mg iv on days 1 and 2, and orally days 3 through 7. These cycles were repeated at intervals of 3–4 weeks, depending upon recovery of blood counts. All 18 patients responded to treatment in terms of hgb, platelets or both. For the first episodes of AIHA (n=17) mean starting hgb was 8.1g/dL (range 4.0–12.1) and mean post-treatment hgb was 13.2 g/dL(range 10.0–15.4)(Table 1). The three patients with ITP had a platelet increase from nadirs of 1,000, 1,000 and 14,000 to 408,000, 161,000 and 135,000, respectively. Mean duration of initial response was 22 months (range 6–41). Nine patients relapsed and were retreated with RCD. Again, all 9 responded, and had a mean increase in hgb of 5.1g/dL (range 1.4–7.7) with a mean duration of second response of 16 months(range 3–33). Overall, median survival from initiation of RCD was 70 months (95% CI; 46 to an upper limit not-yet determinable, with follow-up to 8/2006). Of 8 patients with post-treatment Coombs data available for the first episode of AIHA, 4 (50%) converted to Coombs negativity (Table2) and had a mean duration of response of 23.0 months (range 12–41) vs 8.8 months for those who did not convert(range 6–11). In all AIHA episodes (including repeat episodes) with post-treatment Coombs data available (n=18), 6 of 18 (33%) converted to Coombs negativity. The mean duration of response was 19.8 months (range 6–41) for all episodes with conversion to Coombs negativity, vs 7.0 months for those without(range 3–12). This finding that Coombs conversion portends a longer duration of response suggests treatment goals for AIHA should be a conversion to Coombs negative, and not stopped with recovery of hgb. Table 1. Hemoglobin response to RCD N Mean Std Deviation Min Hgb Max Hgb at start episode 1 17 8.1 g/dL 2.1 4.0 g/dL 12.1 g/dL Hgb at end episode 1 17 13.2 g/dL 1.4 10.0 g/dL 15.4 g/dL Hgb delta episode 1 17 5.1 g/dL 2.3 1.7 g/dL 10.2 g/dL Hgb at start episode 2 9 8.4 g/dL 2.3 5.3 g/dL 12.2 g/dL Hgb at end episode 2 9 13.5 g/dL 1.4 12.3 g/dL 16.6 g/dL Hgb delta episode 2 9 5.1 g/dL 2.1 1.4 g/dL 7.7 g/dL Table 2. Post-treatment Coombs status and response duration N Mean duration of response (in months) Post-treatment Coombs negativity in episode 1 4 22.2 (range 12-41) Post-treatment Coombs positivity in episode 1 4 8.8 (range 6-11) Post-treatment Coombs negativity in all episodes 6 19.8 (range 6-41) Post-treatment Coombs positivity in all episodes 12 7.1 (range 3-12)
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Casanova, Aurora, Javier Ariza, Manuel Rubio, Cristina Masuet, and Ramón Díaz. "BrucellaCapt versus Classical Tests in the Serological Diagnosis and Management of Human Brucellosis." Clinical and Vaccine Immunology 16, no. 6 (April 15, 2009): 844–51. http://dx.doi.org/10.1128/cvi.00348-08.

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ABSTRACT The BrucellaCapt test is an immunocapture agglutination test suggested as a possible substitute for the Coombs test in the diagnosis of human brucellosis. Here it is compared with classical tests using 321 samples from 48 patients with brucellosis (6.9 ± 1.7 samples per patient), including 20 patients with focal disease and 8 patients with a total of 9 relapse episodes (mean follow-up, 18 months). The BrucellaCapt test was used according to the manufacturer's instructions, and we also used a variant of the BrucellaCapt test in which the microtiter plates were not coated with antibodies against total human immunoglobulin (BCAPV). The correlation between the BrucellaCapt and BCAPV tests was 0.982 (P < 0.001), with 260 coincident pairs of titers (81%). The areas under the receiver operating characteristic curve for the BrucellaCapt and BCAPV tests with respect to the Coombs test were 0.969 and 0.960, respectively. Upon admission, the BrucellaCapt, BCAPV, and Coombs tests and the microagglutination test (MAT) were positive for all cases: titers were 1/2,560 by the BrucellaCapt test, 1/2,560 by the BCAPV test, 1/1,280 by the Coombs test, and 1/320 by the MAT. The decreases in the BrucellaCapt and BCAPV titers over time were pronounced in comparison with the Coombs titers. Cumulative probabilities of persistence 12 months after therapy were as follows: 80% by the BrucellaCapt test, 80% by the BCAPV test, 87% by the Coombs test, and 35% by the MAT. Serological changes during relapse were detected in seven cases (88%) by the Coombs test, in five cases by the BrucellaCapt and BCAPV tests, and in three cases by the MAT. The BrucellaCapt test is a sensitive, specific, and simple test for routine use in human brucellosis. Similar results were obtained with the BCAPV test. However, in some cases of relapse and chronic forms of the disease, the slight changes observed in low-affinity antibodies alone are better detected by the Coombs test.
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Jaime-Pérez, J. C., and C. Almaguer-Gaona. "Rediscovering the Coombs test." Medicina Universitaria 18, no. 72 (July 2016): 185–86. http://dx.doi.org/10.1016/j.rmu.2016.07.001.

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Haghdoost, Mehdi, Lily Ansari, and Hamid Owaysee Osquee. "Comparison of Brucellacapture and Coombs wright and Wright in the diagnosis of Brucellosis." Journal of Research in Clinical Medicine 9, no. 1 (March 18, 2021): 15. http://dx.doi.org/10.34172/jrcm.2021.0015.

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Introduction: Rapid and accurate diagnosis of the disease can have many effects on the healing and recovery of patients, so we decided to investigate the accuracy of Brucella capture diagnosis with Coombs-Wright in patients with brucellosis. Materials and Methods: The present study was descriptive and on patients who were referred to clinics with symptoms of brucellosis. Blood samples were taken from all patients. Patient information including age, sex, response to Coombs, Coombs Wright, and Brucella capture tests, as well as patient response to treatment, were entered into a pre-prepared checklist. After obtaining laboratory tests for serological tests, patients were finally included in all patient information, including demographic information, laboratory tests, and analyzed by SPSS v16. Results: This study was performed on 91 patients with brucellosis with a mean age of 34.6 years and 75.8% male. In this study, 84.6% of patients showed a positive Coombs test and 26.4% of patients showed a titer of 1.80. 85.7% of the patients showed positive Coombs Wright test and 29.7% of the patients had a titer of 160.1. In the study of Brucella capture tests in patients, 98.9% of patients showed a positive test, of which 34.1% had a titer of 1.60% of the test. Conclusion: The results of this study showed that the Brucella capture test is a powerful test for the diagnosis of brucellosis, and in the same condition, patients are more likely to be diagnosed with two Wright and Coombs-Wright tests.
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Dissertations / Theses on the topic "Coombs"

1

Abu-Maila, Y. S. "Geomorphic and hydrologic processes in Coombs Brook, Macclesfield Forest." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378012.

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BOUILLON, CHAMOUX NATHALIE. "Les anemies hemolytiques autoimmunes a test de coombs negatif." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13066.

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Johnson, Tim. "A reformulation of Coombs' theory of unidimensional unfolding, by representing attitudes as intervals." Connect to full text, 2004. http://hdl.handle.net/2123/612.

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Thesis (Ph. D.)--University of Sydney, 2004.
Title from title screen (viewed 7 May 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology, Faculty of Science. Includes bibliographical references. Also available in print form.
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Johnson, Timothy Kevin. "A reformulation of Coombs' Theory of Unidimensional Unfolding by representing attitudes as intervals." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/612.

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An examination of the logical relationships between attitude statements suggests that attitudes can be ordered according to favourability, and can also stand in relationships of implication to one another. The traditional representation of attitudes, as points on a single dimension, is inadequate for representing both these relations but representing attitudes as intervals on a single dimension can incorporate both favourability and implication. An interval can be parameterised using its two endpoints or alternatively by its midpoint and latitude. Using this latter representation, the midpoint can be understood as the �favourability� of the attitude, while the latitude can be understood as its �generality�. It is argued that the generality of an attitude statement is akin to its latitude of acceptance, since a greater semantic range increases the likelihood of agreement. When Coombs� Theory of Unidimensional Unfolding is reformulated using the interval representation, the key question is how to measure the distance between two intervals on the dimension. There are innumerable ways to answer this question, but the present study restricts attention to eighteen possible �distance� measures. These measures are based on nine basic distances between intervals on a dimension, as well as two families of models, the Minkowski r-metric and the Generalised Hyperbolic Cosine Model (GHCM). Not all of these measures are distances in the strict sense as some of them fail to satisfy all the metric axioms. To distinguish between these eighteen �distance� measures two empirical tests, the triangle inequality test, and the aligned stimuli test, were developed and tested using two sets of attitude statements. The subject matter of the sets of statements differed but the underlying structure was the same. It is argued that this structure can be known a priori using the logical relationships between the statement�s predicates, and empirical tests confirm the underlying structure and the unidimensionality of the statements used in this study. Consequently, predictions of preference could be ascertained from each model and either confirmed or falsified by subjects� judgements. The results indicated that the triangle inequality failed in both stimulus sets. This suggests that the judgement space is not metric, contradicting a common assumption of attitude measurement. This result also falsified eleven of the eighteen �distance� measures because they predicted the satisfaction of the triangle inequality. The aligned stimuli test used stimuli that were aligned at the endpoint nearest to the ideal interval. The results indicated that subjects preferred the narrower of the two stimuli, contrary to the predictions of six of the measures. Since these six measures all passed the triangle inequality test, only one measure, the GHCM (item), satisfied both tests. However, the GHCM (item) only passes the aligned stimuli tests with additional constraints on its operational function. If it incorporates a strictly log-convex function, such as cosh, the GHCM (item) makes predictions that are satisfied in both tests. This is also evidence that the latitude of acceptance is an item rather than a subject or combined parameter.
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Johnson, Timothy Kevin. "A reformulation of Coombs' Theory of Unidimensional Unfolding by representing attitudes as intervals." University of Sydney. Psychology, 2004. http://hdl.handle.net/2123/612.

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An examination of the logical relationships between attitude statements suggests that attitudes can be ordered according to favourability, and can also stand in relationships of implication to one another. The traditional representation of attitudes, as points on a single dimension, is inadequate for representing both these relations but representing attitudes as intervals on a single dimension can incorporate both favourability and implication. An interval can be parameterised using its two endpoints or alternatively by its midpoint and latitude. Using this latter representation, the midpoint can be understood as the �favourability� of the attitude, while the latitude can be understood as its �generality�. It is argued that the generality of an attitude statement is akin to its latitude of acceptance, since a greater semantic range increases the likelihood of agreement. When Coombs� Theory of Unidimensional Unfolding is reformulated using the interval representation, the key question is how to measure the distance between two intervals on the dimension. There are innumerable ways to answer this question, but the present study restricts attention to eighteen possible �distance� measures. These measures are based on nine basic distances between intervals on a dimension, as well as two families of models, the Minkowski r-metric and the Generalised Hyperbolic Cosine Model (GHCM). Not all of these measures are distances in the strict sense as some of them fail to satisfy all the metric axioms. To distinguish between these eighteen �distance� measures two empirical tests, the triangle inequality test, and the aligned stimuli test, were developed and tested using two sets of attitude statements. The subject matter of the sets of statements differed but the underlying structure was the same. It is argued that this structure can be known a priori using the logical relationships between the statement�s predicates, and empirical tests confirm the underlying structure and the unidimensionality of the statements used in this study. Consequently, predictions of preference could be ascertained from each model and either confirmed or falsified by subjects� judgements. The results indicated that the triangle inequality failed in both stimulus sets. This suggests that the judgement space is not metric, contradicting a common assumption of attitude measurement. This result also falsified eleven of the eighteen �distance� measures because they predicted the satisfaction of the triangle inequality. The aligned stimuli test used stimuli that were aligned at the endpoint nearest to the ideal interval. The results indicated that subjects preferred the narrower of the two stimuli, contrary to the predictions of six of the measures. Since these six measures all passed the triangle inequality test, only one measure, the GHCM (item), satisfied both tests. However, the GHCM (item) only passes the aligned stimuli tests with additional constraints on its operational function. If it incorporates a strictly log-convex function, such as cosh, the GHCM (item) makes predictions that are satisfied in both tests. This is also evidence that the latitude of acceptance is an item rather than a subject or combined parameter.
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Schneider, Thierry. "Etude de 2 techniques immuno-hematologiques utilisees pour la recherche d'anticorps anti-erythrocytaires (r. A. I. )." Lille 2, 1993. http://www.theses.fr/1993LIL2M286.

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Ross, Pierre-Simon, and n/a. "Volcanology of the Mawson Formation at Coombs and Allan Hills, South Victoria Land, Antarctica." University of Otago. Department of Geology, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070418.151642.

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The Jurassic Ferrar large igneous province of Antarctica contains significant mafic volcaniclastic deposits, underlying the Kirkpatrick flood basalts. In South Victoria Land, the mafic volcaniclastics are referred to as the Mawson Formation. At Coombs Hills, the Mawson is interpreted as filling a large vent complex, which was re-examined in detail to better understand vent-forming processes. Two contrasting types of cross-cutting volcaniclastic bodies were found in the complex, both of which are interpreted to have been forcefully emplaced from below into existing, non-consolidated debris. The first type consists of country rock-rich lapilli-tuff pipes. These are interpreted as fossilized remnants of subterranean debris jets which originated when phreatomagmatic explosions occurred near the walls or floor of the vent complex, causing fragmentation of both magma and country rock. The second type of cross-cutting body consists of basalt-rich tuff-breccias and lapilli-tuffs, some of which could have been generated by explosions taking place within pre-existing basalt-bearing debris, well away from the vent walls. Other basalt-rich zones, accompanied by domains of in situ peperite and coherent basalt, are inferred to have originated by less violent processes. At nearby Allan Hills, the Mawson can be divided into two informal members, m₁ and m₂. Member m₁ is exposed only at central Allan Hills, consists essentially of sedimentary material from the underlying Beacon Supergroup, and is interpreted as a [less than or equal to]180 m-thick debris avalanche deposit. Most megablocks in m₁ were derived from the late Triassic Lashly Formation, parts of which were probably only weakly consolidated in the Jurassic. Sandstone breccias dominate volumetrically over megablocks within the deposits. This indicates pervasive and relatively uniform fragmentation of the moving mass, and probably reflects the weak and relatively homogeneous nature of the material involved. The avalanche flowed into a pre-existing topographic depression carved into the Beacon sequence, and flow indicators reveal a northeastward movement. Sparse globular basaltic megablocks suggest that Ferrar intrusions played a role in triggering the avalanche. Member m₂, which is exposed at both central and southern Allan Hills, consists predominantly of metre-thick basaltic volcaniclastic layers that fall into three broad categories: (1) poorly sorted, coarse lapilli-tuff and tuff-breccia; (2) block-rich layers; (3) tuff and fine lapilli-tuff. The former type is interpreted as the deposits of high-concentration pyroclastic density currents (PDCs), probably formed during the collapse of phreatomagmatic eruption plumes. Occasional block-rich layers probably were formed by both ballistic fall from local vents and pyroclastic flows, and the finer-grained layers were probably deposited by dilute PDCs. Dilute, moist turbulent currents were also likely responsible for the generation and deposition of large ([less than or equal to]4.5 cm) rim-type accretionary lapilli. The thick layers are locally underlain by or interbedded with thin tuff ring-style volcaniclastic layers, and all the layers are underlain and invaded by basalt-rich tuff-breccias and lapilli-tuffs. COMPLETE REFERENCE: Ross, P.-S. (2005) Volcanology of the Mawson Formation at Coombs and Allan Hills, South Victoria Land, Antarctica. PhD Thesis, University of Otago, Dunedin, New Zealand, 400 pages, 46 tables, 162 figures, plus appendices.
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Lambert, Maria T. "Attack of the Mommy Mafia| Examining The Honest Company's Use of Coombs' SCCT Strategies." Thesis, University of Louisiana at Lafayette, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1593182.

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A crisis can threaten the existence of an organization, and in this social media age, information is spread at lightning-fast speeds forcing crisis communication managers to work quickly to quell any unflattering press. Companies in crisis situations attempt to mitigate damage and repair reputations using crisis communication strategies, such as Coombs’ Situational Crisis Communication Theory (SCCT). This thesis explored social media as a crisis communication channel for these strategies, by studying an organizational crisis that played out almost entirely on social media, through the lens of SCCT.

This thesis used six statements made by The Honest Company during a 2013 crisis where stakeholders accused the company of bullying a working mother over trademark rights. The company’s crisis communication messages were retrieved, and by using discourse analysis the messages were examined through the guidelines of the SCCT model, which allowed categorization of the messages according to SCCT, analysis of their effectiveness, and the defining of SCCT challenges in analyzing this organizational conflict aggrandized through social media.

This study found that even though The Honest Company did not strictly adhere to SCCT’s guidelines, it was able to flourish and surpass consumer expectations after the crisis ended. The examination of this crisis offered insight into SCCT’s lack of clarity and direction concerning its crisis types, strategies, and guidelines. It also offered suggestions for more specific crisis types and the expansion of crisis types for SCCT.

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Coombs, Katie Marie. "Behavioral consequences following AAV mediated hippocampal EAAC1 knockdown." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/coombs/CoombsK0507.pdf.

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Thomas, Gilles. "Les anemies hemolytiques auto-immunes a test de coombs negatif : a propos de deux cas." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13025.

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Books on the topic "Coombs"

1

Coombs, Edith Grace. Edith Grace Coombs. [Toronto: Heliconian Club, 1985.

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Tim, Rowse. Nugget Coombs: A reforming life. Cambridge, UK: Cambridge University Press, 2002.

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Tim, Rowse. Nugget Coombs: A reforming life. Cambridge: Cambridge Univesity Press, 2002.

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E, Wallace Margaret, Levitt Judith S, and American Association of Blood Banks., eds. Current applications and interpretations of the Direct Antiglobulin Test. Arlington, Va: American Association of Blood Banks, 1988.

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Jack Coombs: A life in baseball. Jefferson, N.C: McFarland & Co., 2008.

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Partington, Geoffrey. Hasluck versus Coombs: White politics and Australia's aborigines. Sydney: Quakers Hill Press, 1996.

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Fawcett, William B. Transitions between farming, hunting & gathering along the Fremont/Puebloan frontier: Archaeological evidence from Coombs Cave and field near Moab, Utah. Logan, UT: Utah State University, 1999.

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Grand Opera House (London, Ont.), ed. Grand Opera House, London, Ont., programme: Season 1897-98, matinee and night, Saturday Nov. 27, Coombs-Waldorf Company in "Bleak House". [S.l: s.n., 1986.

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Monetary policy and inflation targeting (1997 Kirribilli, Australia). Monetary policy and inflation targeting: Proceedings of a conference : held at the H.C. Coombs Centre for Financial Studies, Kirribilli on 21/22 July 1997. Edited by Lowe Philip. [Australia]: Reserve Bank of Australia, 1997.

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Kent, Christopher, Renee Fry, and Callum Jones. Inflation in an era of relative price shocks: Proceedings of a conference held at the H.C. Coombs Centre for Financial Studies, Kirribilli on 17-18 August 2009. Sydney: Reserve Bank of Australia, 2010.

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Book chapters on the topic "Coombs"

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Kaiser, Ulrike. "Coombs-Test." In Transfusionsmedizin für Technische Assistenten, 107–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58909-0_26.

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Bolliger, Anne Provencher. "Antiglobulin (Coombs) Test." In Encyclopedia of Immunotoxicology, 48–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-54596-2_106.

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Delaney, Miriam. "The Coombe North." In Irish Housing Design 1950–1980, 187–210. New York : Routledge, 2020. |: Routledge, 2019. http://dx.doi.org/10.4324/9781315442402-9.

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Kozen, Dexter C. "Cook’s Theorem." In The Design and Analysis of Algorithms, 134–37. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-4400-4_25.

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Cook, R. Dennis. "Cook’s Distance." In International Encyclopedia of Statistical Science, 301–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-04898-2_189.

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Bennett, P., S. Ouditt, J. Rady, A. Gibson, E. Healey, and N. Macpherson-Grant. "The Prehistory of Holywell Coombe." In Late Quaternary Environmental Change in North-west Europe: Excavations at Holywell Coombe, South-east England, 263–314. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4908-2_13.

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van der Aalst, Wil. "COOPIS’10 Keynote." In On the Move to Meaningful Internet Systems: OTM 2010, 4–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16934-2_3.

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Moine, Fabienne. "Eliza Cook’s Journal." In The Palgrave Encyclopedia of Victorian Women's Writing, 1–5. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-02721-6_194-1.

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Moine, Fabienne. "Eliza Cook’s Journal." In The Palgrave Encyclopedia of Victorian Women’s Writing, 497–501. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-78318-1_194.

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Westfall, John, and William Sheehan. "1769: Cook’s Tour." In Celestial Shadows, 323–43. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1535-4_12.

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Conference papers on the topic "Coombs"

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Wilson, Kathryn, Steven Montgomery, Anna Hayburn, Pamela Slevin, Lauren Hetherington, Susan Knox, Mary-Beth Toner, and Andrea Stobo. "1011 Creation of a regional guideline for management of coombs positive infants." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference, Liverpool, 28–30 June 2022. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2022. http://dx.doi.org/10.1136/archdischild-2022-rcpch.283.

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Ratakonda, B., and C. Trabue. "A Rare Case of Coombs-Positive Hemolytic Anemia Due to Brown Recluse Spider Bite." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1684.

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Costa, Antonio Neudimar Bastos, MICHELINE MARIA ARAGÃO FERNANDES, ELINE DE VASCONCELOS BARBALHO, MARIA SORAIA DA CUNHA ARAUJO, and ANA KÉLVIA ARAÚJO ARCANJO. "ALOIMUNIZAÇÃO POR ANTICORPOS IRREGULARES: O DESAFIO CELULAR PARA A TRANFUSÃO SANGUÍNEA SEGURA." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6907.

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Introdução: Os anticorpos irregulares surgem como resposta do sistema humoral de um individuo exposto a antígenos não próprios do seu organismo. Com o aumento da expectativa de vida e o desenvolvimento tecnológico, vêm se observando ampliação no número de doenças crônico-degenerativas e cirurgias mais complexas que requerem maior quantidade de transfusões sanguíneas, o que tem aumentado a freqüência de aloanticorpos antieritrocitários. Muitas funções importantes são desempenhadas por estes antígenos dos sistemas eritrocitários, tais como: estruturais (antígenos do grupo Gerbish), transportadores (sistemas Diego, Kidd e Colton), receptores e moléculas de adesão (sistema Duffy e MNS), enzimática (sistemas Kell e Dombrock), proteínas controladores do complemento (sistemas Chiddo/ Rodgers e Knops). Objetivo: Descrever a finalidade da pesquisa de anticorpo irregular para a transfusão. Metodologia: O presente estudo trata-se de uma revisão de literatura com abordagem qualitativa de artigos das bases de dados SCIELO, LILACS, BIREME e GOOGLE ACADÊMICO. Foram utilizados os seguintes descritores: aloimunização, transfusão, fenotipgem eritrocitária. Utilizaram-se como critérios de inclusão estudos completos disponíveis no idioma português dos anos de 2005 a 2022. Quanto aos critérios de exclusão não foram coletados estudos fora da temática principal da pesquisa e trabalhos com apenas resumos disponíveis. Resultados e Discussão: A pesquisa de anticorpos irregulares tem como princípio a triagem de anticorpos eritrocitários desenvolvidos no soro do paciente pela ausência dos respectivos antígenos correlatos do sistema sanguíneo com a utilização do Soro de Coombs, usando a Técnica de Coombs Indireto. O importante é que as hemácias usadas contenham os principais antígenos que caracterizam os anticorpos dos principais sistemas eritrocitários (Rh, Kell, Duffy, Kidd, Lewis, P, MNS, Luth e Xg). Os anticorpos irregulares ocorrem em até 3% dos pacientes transfundidos, mas, em certos pacientes, esse risco é mais significativo cerca de 7 a 10 % em politransfundidos, 6 a 36% em indivíduos falciformes e 3 a 10% em talassêmicos. A ocorrência de anticorpos irregulares em pacientes politransfundidos tem estimulado pesquisas com o objetivo de determinar a freqüência de aloimunização em populações distintas. Conclusão: O presente estudo apresentou a grande importância da pesquisa de anticorpo irregular na rotina dos bancos de sangue para uma transfusão segura.
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Silva, Gabriela Oliveira Morais da, LAURA BARBOSA DA SILVA, MIQUEAS OLIVEIRA MORAIS DA SILVA, and CAROLINE FERREIRA FRATELLI. "ASPECTOS IMUNOLÓGICOS DA DOENÇA HEMOLÍTICA DO RECÉM-NASCIDO: UMA REVISÃO." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6306.

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Introdução: A Doença Hemolítica do Recém-Nascido (DHRN) é decorrente de uma condição causada pela aloimunização materna aos antígenos dos eritrócitos, na qual há destruição dos eritrócitos fetais e neonatais. Os efeitos apresentados no recém-nascido, mediantes de incompatibilidade de eritrócitos maternos e fetais, vão desde a anemia e a hidropsia fetal até a hiperbilirrubinemia. Objetivo: Realizar uma revisão integrativa acerca da Doença Hemolítica do Recém-Nascido, levando em consideração as alterações imuno hematológicas presentes. Metodologia: Foi realizada uma revisão integrativa, na qual foi utilizada as bases de dados Scielo, Periódicos capes e PubMed, com descritores controlados estabelecidos pelo DeCS/MeSH: Doença hemolítica; Eritroblastose; Anticorpos; Teste de Coombs; Icterícia. Além disso, os artigos eram open access e foram publicados entre o período de 2018 a 2022. Resultados e Discussão: Com os 21 artigos selecionados, observou-se que os antígenos do sistema Rh, especialmente o antígeno D, são responsáveis por 95% dos casos de DHRN. O contato da gestante com sangue incompatível leva à resposta imune primária contra o antígeno Rh. Em posterior exposição ao antígeno, uma rápida resposta celular e humoral inicia-se com a produção específica de anticorpos anti-Rh da classe IgG, que cruzam a placenta, causando hemólise fetal quando atinge a membrana do eritrócito Rh+. A pesquisa de anticorpos irregulares, por meio do teste de Coombs Indireto (CI), deve ser realizada em gestantes. Nesse sentido, a sensibilização materna só é caracterizada quando esse exame é positivo, isto é, existem anticorpos antieritrocitários na circulação materna tanto em situações de transfusão sanguínea quanto sensibilização em gravidez passada, detectando imunoglobulinas IgG ou frações do complemento ligadas às hemácias. Nos casos em que o CI é negativo, a gestante é tida como de risco, sendo orientada a realizar a profilaxia ante e pós-natal. Atualmente, é utilizado a Imunoglobulina anti-D profilaticamente após o parto, destacando que quanto menor o intervalo entre o parto e a aplicação da profilaxia, maior eficácia. Conclusão: Diante do exposto, notou-se a importância dos antígenos do sistema Rh, sobretudo, o antígeno D, no desenvolvimento da DHRN. Tais achados contribuem, portanto, tanto para o entendimento da DHRN quanto para a relevância de sua profilaxia.
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Santos, João Vitor Ribeiro dos, Mariana Spitz, and Ana Carolina Andorinho. "Stroke secondary to thrombotic microangiopathy." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.300.

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Introduction: Thrombotic thrombocytopenic purpura (TTP) is a hematological disease resulting from the ADAMTS 13 plasmatic protein deficit. It can be congenital or sporadic, and is usually autoimmune. Pathological platelet adhesion occurs, leading to microthrombi in capillary and arterial circulation, microangiopathic anemia and ischemia. The clinical picture includes thrombocytopenia, renal dysfunction, fluctuating neurological symptoms, microangiopathic hemolytic anemia, and fever. Methods: Case report of a 51-year-old male hypertensive patient, diagnosed with idiopathic thrombocytopenic purpura (ITP) 10 years ago and submitted to splenectomy 5 years ago, who developed acute cholecystitis. He underwent urgent colecistectomy, and on the fourth postoperative day presented sudden space and time disorientation, transcortical motor aphasia and right faciobrachial paresis, with ipsilateral Babinski and Hoffman signs. Results: Brain CT showed left frontoparietal hypodensity. During hospitalization, there was worsening of renal function, increased LDH, and thrombocytopenia. Hematoscopy identified signs of intravascular hemolysis (erythrocyte fragmentation, reticulocytosis, helmet erythrocytes). Direct Coombs was negative. There was no history of heparin use. TTP was diagnosed, and fresh frozen plasma and prednisone 1mg/kg were prescribed. There was resolution of thrombotic microangiopathy, with subsequent increase of platelet levels, decreased LDH and improved hematoscopy. Conclusions: This case illustrates a rare cause of stroke and an unusual association of two hematological conditions: ITP and TTP. The treatment of TTP consists of replacement of deficient ADAMTS13 protein through plasmapheresis or fresh frozen plasma. The use of immunosuppressants is also associated, initially with glucocorticoids, followed by rituximab or splenectomy in order to prevent recurrences.
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Apolinário, Joelma Maria dos Santos da Silva, Caroline Sousa E. Silva, Thaís Rodrigues Dos Santos, Beatriz Michele Silva E. Silva, Bruna Santos Costa Da Silva, Márcia Lima Da Silva, and Aline Da Silva Dos Anjos. "DISPARIDADES CORRELACIONADAS AOS EXAMES HEMATOLÓGICOS DECORRENTE DO USO INAPROPRIADO DE MEDICAMENTOS." In I Congresso Brasileiro de Hematologia Clínico-laboratorial On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2002.

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Introdução: Muitos medicamentos interferem no resultado final dos exames laboratoriais, em se tratando principalmente da hematologia propriamente dita, uma vez que os pacientes não descrevem sua utilização no ato da coleta, dentre os medicamentos os mais causadores de discrepâncias são: anticoagulantes orais, anti-inflamatórios, analgésicos, anti-hipertensivos, psicotrópicos, e com isso causam discrasias sanguíneas. Objetivo: Investigar e comprovar as disparidades ocasionadas por medicamentos em relação aos exames hematológicos. Metodologia: O estudo caracteriza-se por apresentar uma análise acerca da hematologia. A realização deste foi embasada em pesquisas de abordagem qualitativa e descritiva, quanto aos procedimentos, revisão bibliográfica ou método de revisão integrativa da literatura. Os dados foram coletados nas bases de dados SciELO, BDENF, LILACS e MEDLINE, com recorte temporal de 2011 a 2021. Resultados: Os antibióticos e antivirais causam bastante interferências, geralmente aqueles que contém o anel beta-lactâmico como a penicilina, ampicilina, os antivirais, como o interferon-α-2a peguilado, em relação aos psicotrópicos o valproáto de sódio anticonvulsivante capaz de causar depressão da médula óssea, resultando em aplasia de medula ou síndrome mielodisplásica, ocorrendo citopenia periférica que podem afetar outras linhagens celulares. Com isso, é possível observar plaquetopenia, neutropenia, macrocitose. Dos anti-hipertensivos, o metildopa eficaz em reduzir a pressão arterial, observa-se que a prova de Coombs direto positiva em até 10% dos pacientes que utilizam essa droga em doses de 2 gramas/dia e uma minoria apresenta plaquetopenia, esferocitose e hemólise que podem ser acentuadas, os anti-hipertensivos como o captopril, enalapril, propranolol podem causar discrasias hematológicas o enalapril interferi no fator anti-núcleo positivo. Conclusão: Diante disso podemos de fato comprovar as intercorrências correlacionadas ao uso de medicamentos com as análises hematológicas, uma vez que os exames laboratoriais exercem um papel primordial no que diz respeito ao diagnóstico de diversas doenças, onde os fármacos mais utilizados predispõem às alterações pós analíticas de várias dosagens sanguíneas.
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Sens, Marilin, and Otto Henrique May Feuerschuette. "Anemia fetal grave secundária a hemorragia feto-materna." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311114.

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Gestante de 28 anos, G2A1, tipagem sanguínea O Rh +, sem intercorrências no pré-natal. Com 39 semanas procura o atendimento em razão de pródromos de trabalho de parto. Durante atendimento, realizou-se cardiotocografia (CTG) categoria 1, e a paciente foi liberada após exame. Retornou após 5 horas em trabalho de parto, e durante a internação foi realizado CTG com padrão sinusoidal, categoria 3. Perante a hipótese de sofrimento fetal provavelmente associado a anemia fetal, realizou-se cesariana. Recém-nascido do sexo masculino, com 3345 g, índice de Apgar de 6 ao 1º minuto e de 7 ao 5º minuto, no qual foi realizada ventilação com pressão positiva em sala de parto em função de palidez cutaneomucosa e dessaturação. Foi transferido para unidade terapia intensiva neonatal, onde permaneceu internado por quatro dias com anemia grave (hemoglobina ao nascer de 4,8 g/dL). Durane a internação, foi feita uma transfusão sanguínea. Tipagem sanguínea do RN O+, teste de Coombs direto negativo. O estudo de infecções virais (citomegalovírus e parvovírus B19) e o teste de Kleihauer-Betke na mãe foram negativos. A hemorragia feto-materna consiste na transferência de sangue fetal para a circulação materna. A grande maioria é de sangramentos de pequeno volume sem significado hemodinâmico, mas que podem levar à aloimunização. É considerada grave quando há transferência de mais de 30 ml de sangue fetal. Considerada uma situação incomum, ocorre entre 0,02 a 1,7% das gestações e gera suspeita perante um feto com franca diminuição dos movimentos e que apresenta m traçado não reativo, com presença eventual de padrão sinusoidal e desacelerações tardias. O padrão de frequência cardíaca fetal (FCF) sinusoidal está fortemente associado à anemia fetal grave de qualquer causa e pode ser uma das primeiras manifestações de hemorragia feto-materna (HFM) maciça. Em uma revisão sistêmica de 32 casos de anemia fetal grave (hemoglobina fetal ou neonatal 1,9 a 7,2 g/dL ) associada com HFM, o padrão de FCF foi relatado como sinusoidal em 17 dos 24 casos.
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Silva, Nicoly Ferreira, Adriano Antônio Dos Anjos Lima Filha, Ana Carolina Medeiros Andrade, Júlia Diniz De Souza, and Maria Do Socorro Viana Silva De Sá. "ASPECTOS IMUNOLÓGICOS DA ALERGIA À PROTEÍNA DO LEITE DE VACA MEDIADA POR IGE." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/983.

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Introdução: A alergia à proteína do leite de vaca (APLV) é uma hipersensibilidade alimentar documentada, majoritariamente, como tipo I (IgE mediada) pela classificação de Gell e Coombs que aborda reações mediadas pelo sistema imune inato e pelo adaptativo. No Brasil, estudos demonstram que crianças com sintomas gastroenterológicos e suspeita de APLV têm prevalência de 5,4% e incidência de 2,2%, sendo essa a alergia alimentar mais comum abaixo de quatro anos de idade. Objetivo: Analisar publicações que abordam os aspectos imunológicos da hipersensibilidade ao leite de vaca mediada por IgE. Material e metodologia: Trata-se de uma revisão bibliográfica, realizada em março de 2021. Para a obtenção dos artigos científicos foi feito um cruzamento de informações advindas das bases de dados Pubmed, Uptodate, LILACS e MEDLINE. Adotou-se os seguintes critérios inclusivos: artigos de revisão sistemática e que foram publicados nos últimos 5 anos (2016-2021). Resultados: As reações alérgicas agudas comumente são respostas imunológicas IgE mediadas - relacionadas a um ou mais alérgenos presentes na composição proteica do leite bovino - sendo mais toleradas a partir dos três anos de idade. Entre os alérgenos, têm-se subtipos da caseína (alfa, beta e kappa), que compõe cerca de 80% do material proteico, e do soro do leite destacando os subtipos BLG (beta-lactoglobulina) e ALA (alfa-lactalbumina). Essas reações variam de sintomas leves a anafilaxia e acontecem até duas horas após exposição ao alérgeno a partir do lançamento de mediadores inflamatórios nos tecidos celulares - sendo a pele o local mais comumente acometido, além de recorrentes manifestações gastrointestinais. Conclusão: Uma vez que não há um único teste ou uma exata combinação de exames capazes de diagnosticar o quadro de APLV, apesar do destaque atribuído ao Teste de Provocação Oral (TPO), é necessária uma avaliação individualizada do paciente com sintomas para essa condição clínica. Deve-se realizar um planejamento nutricional que substitua os lacticínios e apenas reinseri-los na dieta em um momento oportuno, levando em consideração que essa condição tende a ser mais tolerada na idade escolar. Além disso, é essencial a orientação para o uso de epinefrina auto injetável, de modo a evitar reações anafiláticas graves.
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Cabral, Vitória, Geovana Domingues Jardim Soares, Nathalia Brandes Décimo Rodrigues, Eduarda Ponsati Viraque, and Luciana Araújo Lins. "ISOERITRÓLISE NEONATAL EQUINA - REVISÃO DE LITERATURA." In I Congresso Brasileiro Online de Práticas Veterinárias: Uma abordagem para animais de grande porte e produção Animal. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/granvet-22.

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Introdução: A isoeritrólise neonatal equina (INE) é uma enfermidade de potros recém-nascidos que ocorre entre 1 a 2% dos partos. É definida pela formação de anticorpos maternos contra as hemácias do potro, que são transferidos por meio da ingestão do colostro, levando a um quadro de hemólise imunomediada. É causada pela incompatibilidade do grupo sanguíneo entre potro e égua. Normalmente acomete potros de éguas multíparas, mas há casos raros que podem afetar potros de éguas primíparas. Objetivo: Este trabalho teve por objetivo apresentar uma revisão bibliográfica sobre a isoeritrólise neonatal equina. Material e métodos: Foi realizada uma revisão de literatura com base em artigo científicos disponíveis on line, através de pesquisa em plataformas de pesquisa voltadas à indexação de publicações científicas. Resultados: Uma das principais características dos potros com INE é que durante a gestação e parto eles não apresentam alterações, sendo perceptíveis apenas após 2 a 24 horas da ingestão de colostro. Dependendo da quantidade e da atividade dos anticorpos absorvidos, determina-se a rapidez do início dos sinais e a gravidade do quadro clínico, que podem ser hiperagudos, agudos, subagudos ou subclínicos. Os sinais gerais consistem em fraqueza, depressão, redução do reflexo de sucção e icterícia. O diagnóstico pode ser definido através do histórico e análise clínica e como exame complementar pode ser utilizado teste de Coombs (antiglobulina direta) que detecta a presença de anticorpos. O tratamento varia conforme a gravidade dos sinais clínicos. O potro deve ser alimentado com leite correspondente a no mínimo 10% do peso vivo, a cada 2 horas se necessário através de sonda nasogástrica, utilizando o colostro que seja de outra progenitora. Nos casos mais graves, há a necessidade de realizar a transfusão sanguínea para amenizar a anemia, além de tratamento suporte. Conclusão: A Isoeritrólise neonatal equina é uma doença de suma importância, onde criadores e médicos veterinários devem ficar atentos para detectar os sinais clínicos no começo e tomar medidas terapêuticas para que se evite este quadro clínico. O prognóstico irá depender da quantidade e atividade dos anticorpos absorvidos e não está, necessariamente, equivalente à velocidade de início dos sinais.
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Matos, Amanda Noleto de, ADRIANO AGUIAR DA SILVA, ANDRESSA AGUIAR DA SILVA, FIRAS ABDEL KAREEM TRAIREH, and KADMIEL CÂNDIDO. "MANEJO E IMUNOPATOLOGIA DA ANEMIA HEMOLÍTICA AUTOIMUNE." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6786.

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Introdução: Anemia Hemolítica Autoimune (AHAI) é uma condição clínica em que ocorre a destruição dos eritrócitos, por conta da ligação de autoanticorpos circulantes contra antígenos de glóbulos vermelhos resultando em uma destruição via sistema completo ou sistema reticulo endotelial. Objetivo: Descrever o manejo e processo fisiopatogênico da anemia hemolítica autoimune. Metodologia: Trata-se de um estudo qualitativo de revisão bibliográfica realizado através da busca ativa nas bases de dados PUBMED, NATURE immunology e Google acadêmico de artigos publicados nos últimos 2 anos na língua portuguesa e inglesa. Resultados: A AHAI pode ser classificada com base na sua etiologia, podendo ser primária ou secundária, e temperatura sendo quente, fria ou mista. Na primária, não ocorre associação a outra doença base, já a secundária, normalmente ocorre em associação a um quadro infeccioso bem como doenças autoimunes, quadros de infecções virais ou bacterianas, uso de drogas, tumores, doenças hematológicas etc. Com base na temperatura, os anticorpos quentes do tipo IgG, reagem mais fortemente a temperatura corporal (37ºC) e há hemólise extravascular pelo sistema reticulo endotelial por células fagocíticas esplênicas, que apresentam receptores para a porção Fc dos anticorpos e também para as porções C3 e C4 do complemento. Na AHAI fria, os anticorpos são da classe IgM e reagem a temperaturas entre 4ºC e 18ºC, ocorrendo hemólise intravascular pelos macrófagos do sistema retículo endotelial e normalmente está associada a fixação do complemento, especificamente a proteína C3b. Na mista, os dois tipos de autoanticorpos coexistem. Clinicamente, pode ocorrer palidez cutânea e de mucosas, fraqueza, icterícia, taquicardia, hepatoesplenomegalia e retardo de crescimento. O diagnóstico é realizado através do teste de Coombs direto, mas outros testes, como o teste para comprovação de hemólise e citometria de fluxo, auxiliam quando o primeiro resulta negativo. O tratamento consiste em reduzir o grau de hemólise, melhorando os níveis de hemoglobina e resultando na melhora dos sintomas. No caso de AHAI secundária, deve realizar o tratamento da causa-base. Conclusão: Com base no exposto o entendimento dos processos fisiopatogênicos da AHAI, além do seu diagnóstico e tratamento traz benefícios a população por trazer informações relevantes ao seu manejo precoce e eventuais complicações.
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Reports on the topic "Coombs"

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Coombs, HC with Mrs Coombs - March 1951. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002847.

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Coombs, HC with Mrs Coombs - c.1960. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002844.

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Coombs, HC with Mrs Coombs and family - March 1951. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002846.

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Coombs, HC with Mrs Coombs and family - March 1951. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002845.

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Coombs, HC - 1966. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002751.

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Coombs, HC with Mrs Coombs and Mrs McPherson - January 1966. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002770.

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Coombs, HC - With Mrs Coombs and friends, Wangaratta - March 1965. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002752.

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Coombs, HC with Mrs Coombs and Mrs Garnett Carroll - August 1962. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002849.

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Coombs, HC - December 1954. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002902.

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10

Coombs, HC - June 1945. Reserve Bank of Australia, September 2022. http://dx.doi.org/10.47688/rba_archives_pn-002884.

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