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Journal articles on the topic 'Controlled donation after circulatory death'

Author: Grafiati

Published: 5 April 2025

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1

Dalle Ave, Anne L., and David M. Shaw. "Controlled Donation After Circulatory Determination of Death." Journal of Intensive Care Medicine 32, no. 3 (July 7, 2016): 179–86. http://dx.doi.org/10.1177/0885066615625628.

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Controlled donation after circulatory determination of death (cDCDD) concerns donation after withdrawal of life-sustaining therapy (W-LST). We examine the ethical issues raised by W-LST in the cDCDD context in the light of a review of cDCDD protocols and the ethical literature. Our analysis confirms that W-LST procedures vary considerably among cDCDD centers and that despite existing recommendations, the conflict of interest in the W-LST decision and process might be difficult to avoid, the process of W-LST might interfere with usual end-of-life care, and there is a risk of hastening death. In order to ensure that the practice of W-LST meets already well-established ethical recommendations, we suggest that W-LST should be managed in the ICU by an ICU physician who has been part of the W-LST decision. Recommending extubation for W-LST, when this is not necessarily the preferred procedure, is inconsistent with the recommendation to follow usual W-LST protocol. As the risk of conflicts of interest in the decision of W-LST and in the process of W-LST exists, this should be acknowledged and disclosed. Finally, when cDCDD programs interfere with W-LST and end-of-life care, this should be transparently disclosed to the family, and specific informed consent is necessary.

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2

Clark, Stephen. "Ethical considerations in controlled donation after circulatory death." Annals of Cardiothoracic Surgery 14, no. 1 (January 2025): 61–63. https://doi.org/10.21037/acs-2024-dcd-25.

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3

Rodrigue, James R., Richard Luskin, Helen Nelson, Alexandra Glazier, Galen V. Henderson, and Francis L. Delmonico. "Measuring Critical Care Providers’ Attitudes About Controlled Donation After Circulatory Death." Progress in Transplantation 28, no. 2 (March 20, 2018): 142–50. http://dx.doi.org/10.1177/1526924818765821.

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Introduction: Unfavorable attitudes and insufficient knowledge about donation after cardiac death among critical care providers can have important consequences for the appropriate identification of potential donors, consistent implementation of donation after cardiac death policies, and relative strength of support for this type of donation. The lack of reliable and valid assessment measures has hampered research to capture providers’ attitudes. Design and Research Aims: Using stakeholder engagement and an iterative process, we developed a questionnaire to measure attitudes of donation after cardiac death in critical care providers (n = 112) and examined its psychometric properties. Exploratory factor analysis, internal consistency, and validity analyses were conducted to examine the measure. Results: A 34-item questionnaire consisting of 4 factors (Personal Comfort, Process Satisfaction, Family Comfort, and System Trust) provided the most parsimonious fit. Internal consistency was acceptable for each of the subscales and the total questionnaire (Cronbach α > .70). A strong association between more favorable attitudes overall and knowledge ( r = .43, P < .001) provides evidence of convergent validity. Multivariable regression analyses showed that white race ( P = .002) and more experience with donation after cardiac death ( P < .001) were significant predictors of more favorable attitudes. Conclusion: Study findings support the utility, reliability, and validity of a questionnaire for measuring attitudes in critical care providers and for isolating targets for additional education on donation after cardiac death.

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4

Inci, Ilhan, Sven Hillinger, Didier Schneiter, Isabelle Opitz, Macé Schuurmans, Christian Benden, and Walter Weder. "Lung Transplantation with Controlled Donation after Circulatory Death Donors." Annals of Thoracic and Cardiovascular Surgery 24, no. 6 (2018): 296–302. http://dx.doi.org/10.5761/atcs.oa.18-00098.

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5

Callaghan, C. J., M. S. Qureshi, J. A. Bradley, C. J. E. Watson, and G. J. Pettigrew. "Pancreas Transplantation From Controlled Donation After Circulatory Death Donors." American Journal of Transplantation 13, no. 3 (February 20, 2013): 823. http://dx.doi.org/10.1111/ajt.12030.

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6

Hessheimer, A. J., B. Domínguez-Gil, C. Fondevila, and R. Matesanz. "Controlled Donation After Circulatory Determination of Death in Spain." American Journal of Transplantation 16, no. 7 (March 29, 2016): 2239–40. http://dx.doi.org/10.1111/ajt.13762.

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7

Pérez-Villares, Jose Miguel, Ramón Lara-Rosales, Alberto Fernández-Carmona, Patricia Fuentes-Garcia, Manuel Burgos-Fuentes, and Blas Baquedano-Fernández. "Mobile ECMO team for controlled donation after circulatory death." American Journal of Transplantation 18, no. 5 (January 25, 2018): 1293–94. http://dx.doi.org/10.1111/ajt.14656.

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8

Brogi, Etrusca, Alessandro Circelli, Emiliano Gamberini, Emanuele Russo, Marco Benni, Giancinto Pizzilli, and Vanni Agnoletti. "Normothermic Regional Perfusion for Controlled Donation After Circulatory Death." ASAIO Journal 66, no. 1 (January 2020): e19-e21. http://dx.doi.org/10.1097/mat.0000000000000963.

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9

Gutiérrez Delgado, María del Pilar, Belinda Sánchez Pérez, Jose Antonio Pérez Daga, Francisco Javier León Díaz, and Julio Santoyo Santoyo. "Controlled donation after circulatory death: A present in pancreatic trasnplant." Cirugía Española (English Edition) 99, no. 3 (March 2021): 236–38. http://dx.doi.org/10.1016/j.cireng.2021.02.015.

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10

Gutiérrez Delgado, M. D. P., B. Sánchez Pérez, J. A. Pérez Daga, F. J. León Díaz, and J. Santoyo Santoyo. "Controlled donation after circulatory death in pancreatic trasplant: our present." HPB 23 (2021): S770. http://dx.doi.org/10.1016/j.hpb.2021.08.200.

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11

Le Dorze, Matthieu, Laurent Martin-Lefèvre, Gaëlle Santin, René Robert, Gérard Audibert, Bruno Megarbane, Louis Puybasset, et al. "Critical pathways for controlled donation after circulatory death in France." Anaesthesia Critical Care & Pain Medicine 41, no. 2 (April 2022): 101029. http://dx.doi.org/10.1016/j.accpm.2022.101029.

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12

Murphy, Nicholas, Charles Weijer, Maxwell Smith, Jennifer Chandler, Erika Chamberlain, Teneille Gofton, and Marat Slessarev. "Controlled Donation After Circulatory Determination of Death: A Scoping Review of Ethical Issues, Key Concepts, and Arguments." Journal of Law, Medicine & Ethics 49, no. 3 (2021): 418–40. http://dx.doi.org/10.1017/jme.2021.63.

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13

Savier, Eric, Chetana Lim, and Olivier Scatton. "Liver Transplantation From Controlled Donation After Circulatory Death Donors With Normothermic Regional Perfusion Versus Donation After Brain Death Donors." Liver Transplantation 28, no. 3 (November 22, 2021): 508–9. http://dx.doi.org/10.1002/lt.26363.

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14

Kin, Tatsuya, Hirofumi Noguchi, and Atsushi Kawaguchi. "Is Donation after Circulatory Determination of Death in Japan Uncontrolled or Controlled?" OBM Transplantation 08, no. 02 (June 3, 2024): 1–12. http://dx.doi.org/10.21926/obm.transplant.2402216.

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Using donation after circulatory determination of death (DCD) donors has been shown to be a potential means of increasing the number of donors for organ transplantation. The purpose of this study was to examine the published practice of DCD in Japan to properly define their practice as controlled or uncontrolled. Through the Web of Science database, we systematically searched articles describing uncontrolled DCD, controlled DCD or Maastricht classification. A total of 12 articles (ten articles related to kidney, one to pancreas, another to islet transplantation), which were published between 1999 and 2023 from Japanese institutes, were eligible for our study. Systematic review revealed that most DCD in Japan occurs when a terminally ill patient undergoes an expected cardiac arrest without rapid discontinuation from a ventilator, and in some cases with premortem interventions such as cannulation to the femoral vessels. Surprisingly, these DCD donors in Japan have been categorized as uncontrolled DCD. This categorization confuses the donation and transplantation community globally because the international consensus is that uncontrolled DCD occurs after an unexpected cardiac arrest. Further clear definition of terminology would be required within Japan as well as other countries practicing uncontrolled DCD.

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15

Walker, Wendy, and Magi Sque. "Family bereavement: A case study of controlled organ donation after circulatory death." Nursing in Critical Care 24, no. 4 (May 29, 2019): 229–34. http://dx.doi.org/10.1111/nicc.12436.

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16

Palomo-López, N., L. Martín-Villén, Á. J. Roldán-Reina, Z. Ruiz de Azúa-López, D. X. Cuenca-Apolo, M. Adriaensens-Pérez, Y. Corcia-Palomo, and J. J. Egea-Guerrero. "Results of Controlled Donation After Circulatory Death in a Third-Level Hospital." Transplantation Proceedings 50, no. 2 (March 2018): 536–38. http://dx.doi.org/10.1016/j.transproceed.2017.11.051.

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17

Cypel, Marcelo, Bronwyn Levvey, Dirk Van Raemdonck, Michiel Erasmus, John Dark, David Mason, Allan R. Glanville, et al. "Lung transplantation using controlled donation after circulatory death donors: Trials and tribulations." Journal of Heart and Lung Transplantation 35, no. 1 (January 2016): 146–47. http://dx.doi.org/10.1016/j.healun.2015.10.004.

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18

Okahara, Shuji, Gregory I. Snell, Mark McDonald, Rohit D’Costa, Helen Opdam, David V. Pilcher, and Bronwyn Levvey. "Improving the predictability of time to death in controlled donation after circulatory death lung donors." Transplant International 34, no. 5 (March 30, 2021): 906–15. http://dx.doi.org/10.1111/tri.13862.

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19

Foss, Stein, Espen Nordheim, Dag W. Sørensen, Torgunn B. Syversen, Karsten Midtvedt, Anders Åsberg, Thorleif Dahl, et al. "First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion." Transplantation Direct 4, no. 7 (July 2018): e366. http://dx.doi.org/10.1097/txd.0000000000000802.

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20

Weiss, Matthew J., Laura Hornby, Bram Rochwerg, Michael van Manen, ;. Sonny Dhanani, V. Ben Sivarajan, Amber Appleby, et al. "Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death—Summary Report*." Pediatric Critical Care Medicine 18, no. 11 (November 2017): 1035–46. http://dx.doi.org/10.1097/pcc.0000000000001320.

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21

Boffini, Massimo, Gino Gerosa, Giovanni Battista Luciani, Davide Pacini, Claudio Francesco Russo, Mauro Rinaldi, Amedeo Terzi, et al. "Heart transplantation in controlled donation after circulatory determination of death: the Italian experience." Annals of Cardiothoracic Surgery 14, no. 1 (January 2025): 47–54. https://doi.org/10.21037/acs-2024-dcd-27.

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22

Inci, I., R. Lenherr, S. Hillinger, D. Schneiter, M. Beschir, I. Schmitt-Opitz, R. Schuepbach, M. Schuurmans, C. Benden, and W. Weder. "Lung Transplantation with Controlled Donation After Circulatory Death Donors: Initial Experience in Switzerland." Journal of Heart and Lung Transplantation 36, no. 4 (April 2017): S319. http://dx.doi.org/10.1016/j.healun.2017.01.1528.

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23

Guo, Mingxiao, Linlin Li, and Chunlei Lu. "Characterization of the withdrawal phase in a swine controlled intestinal donation after circulatory death model." Clinical & Investigative Medicine 37, no. 5 (October 4, 2014): 331. http://dx.doi.org/10.25011/cim.v37i5.22013.

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Purpose: Transplantation of donation after cardiac death (DCD) intestine has higher rates of organ failure and complications. Fortunately, this is less grievous in a subclass of DCD called controlled (CDCD), those with irreversible but incomplete brain injury. The aim of the paper is to establish a CDCD porcine model which is closely mimicking human CDCD scenario, and investigate the physiologic changes from withdrawal of ventilatory support to circulatory arrest. Method: Ten domestic crossbred pigs were anesthetized and ventilated with room air. Once all baseline data was taken, atracurium besilate (0.9 mg/kg, 3×ED95) was administered and the ventilator was discontinued while the animal was under deep anesthesia to establish the porcine CDCD model. Meanwhile, heparin (150~200 U/kg) was administered after discontinuation of the ventilator. The time to death and the changes of arterial blood gases and hemodynamic parameters were monitored every 5 minutes until circulatory arrest. In addition, histopathology, ultrastructures (via electron microscope) and expression of tight junction proteins of intestinal mucosa were observed at the baseline and the time of death. Result: The mean time to death was approximately (21.8±3.12 min. Within 5 minutes of removal of the ventilator, there was a hyperdynamic period. Systolic blood pressure and heart rate quickly increased to 118.5±10.4 mmHg and 108.2±4.94 bpm, respectively. Blood pressure and heart rate then reduced rapidly until circulatory arrest. Moreover, the PaO2 quickly dropped to 17.4±3.13 mmHg, the blood gases throughout the apneic time showed a rapid hypercapnia and acidosis. In addition, warm ischemia damaged intestinal mucosa and reduced TJ proteins expression. Conclusion: A new swine CDCD model, simulating three stages of “withdrawal of ventilation, systemic anticoagulation and determination of death”, which closely mimics the human DCD scenario and can thus be used in studies related to organ transplantation, was successfully established.

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24

Pérez‐Sáez, María José, Javier Juega, Ana Zapatero, Jordi Comas, Jaume Tort, Ricardo Lauzurica, and Julio Pascual. "Kidney transplant outcomes in elderly recipients with controlled donation after circulatory death or donation after brain death donors: a registry cohort study." Transplant International 34, no. 12 (November 11, 2021): 2507–14. http://dx.doi.org/10.1111/tri.14141.

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25

Domínguez-Gil, Beatriz, Nancy Ascher, Alexander M. Capron, Dale Gardiner, Alexander R. Manara, James L. Bernat, Eduardo Miñambres, et al. "Expanding controlled donation after the circulatory determination of death: statement from an international collaborative." Intensive Care Medicine 47, no. 3 (February 26, 2021): 265–81. http://dx.doi.org/10.1007/s00134-020-06341-7.

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26

Feo, Marlene, Eduardo Miñambres, Borja Suberviola, Sandra Campos-Fernández, Juncal Sánchez-Arguiano, Maria Kislikova, and María A. Ballesteros. "Controlled Donation After Circulatory Death Program: Analysis and Results at a Tertiary Care Hospital." Transplantation Proceedings 54, no. 1 (January 2022): 70–72. http://dx.doi.org/10.1016/j.transproceed.2021.09.061.

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27

L, Vecchio Dezillio, Stringa P, Machuca M, Papa Gobbi R, Pucci Molineris M, Serradilla J, Andrés Moreno A, Lausada N, Rumbo M, and Hernández Oliveros F. "O-06: Experimental Assessment of Multivisceral Graft Damage in Controlled Donation after Circulatory Death." Transplantation 105, no. 7S (June 22, 2021): S3. http://dx.doi.org/10.1097/01.tp.0000757492.51854.0c.

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28

Oniscu, G. C., L. V. Randle, P. Muiesan, A. J. Butler, I. S. Currie, M. T. P. R. Perera, J. L. Forsythe, and C. J. E. Watson. "In SituNormothermic Regional Perfusion for Controlled Donation After Circulatory Death-The United Kingdom Experience." American Journal of Transplantation 14, no. 12 (October 3, 2014): 2846–54. http://dx.doi.org/10.1111/ajt.12927.

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29

Gay, Samuel, Albrice Levrat, and Didier Dorez. "Controlled donation after circulatory death in France: first results of a nonuniversity pilot centre." Transplant International 31, no. 10 (July 9, 2018): 1178–80. http://dx.doi.org/10.1111/tri.13309.

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30

Loforte, Antonio, Matteo Marro, Erika Simonato, Andrea Costamagna, Marco Ellena, Anna Chiara Trompeo, Marinella Zanierato, Luca Brazzi, Mauro Rinaldi, and Massimo Boffini. "Surgical techniques for cardiac allograft procurement and perfusion in controlled donation after circulatory death." Annals of Cardiothoracic Surgery 13, no. 6 (November 2024): 522–30. http://dx.doi.org/10.21037/acs-2024-dcd-26.

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31

Minambres, Eduardo, Nuria Lavid, Maite Arlaban, Rosalia Valero, Marcos Gómez-Ruiz, Jose Manuel Gonzalez-de la Guerra, Alejandro Ponton, Maria Angeles Ballesteros, and Borja Suberviola. "Excellent Results from Controlled Donation after Circulatory Death Donors Using Abdominal Normothermic Regional Perfusion." Transplantation 101 (August 2017): S37. http://dx.doi.org/10.1097/01.tp.0000525030.91140.d5.

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32

Palleschi, A., V. Musso, R. Lorenzo, D. Tosi, I. Righi, P. Mendogni, V. Rossetti, A. Zanella, and M. Nosotti. "Lung Transplantation from Controlled and Uncontrolled Donation after Circulatory Death Donors. Single Centre Experience." Journal of Heart and Lung Transplantation 39, no. 4 (April 2020): S376. http://dx.doi.org/10.1016/j.healun.2020.01.476.

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33

Kompanje, Erwin J. O., and Jelle L. Epker. "Controlled Donation After Circulatory Determination of Death: Ethical Issues in Withdrawing Life-Sustaining Therapy." Journal of Intensive Care Medicine 33, no. 4 (March 12, 2018): 270–71. http://dx.doi.org/10.1177/0885066617733651.

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34

Lazzeri, Chiara, and Adriano Peris. "UNCONTROLLED DONATION AFTER CIRCULATORY DEATH: A BY-PRODUCT OF THE CONTROLLED? A NARRATIVE REVIEW." European Journal of Transplantation 1, no. 2 (March 2023): 136–42. http://dx.doi.org/10.57603/ejt-016.

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35

Morrissey, Paul. "Pragmatic Aspects of Controlled Donation after Circulatory Death and Ethical Considerations for Alternative Approaches." American Journal of Bioethics 23, no. 2 (January 22, 2023): 14–17. http://dx.doi.org/10.1080/15265161.2022.2159251.

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36

Hoyos Mejia, L., T. Papasotiropoulos, G. Lang, I. Iskender, M. Schuurmans, R. Hage, and I. Opitz. "Controlled Donation After Circulatory Death Lung Transplantation in University Hospital Zurich: 10-years' Experience." Journal of Heart and Lung Transplantation 43, no. 4 (April 2024): S111. http://dx.doi.org/10.1016/j.healun.2024.02.223.

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37

Tanaka, Shin, Jose Luis Campo-Cañaveral de la Cruz, Mariana Gil Barturen, Silvana Crowley Carrasco, Alejandra Romero Román, María Trujillo Sánchez de León, Lucas Hoyos Mejía, et al. "Post-transplant outcomes of standard and extended criteria donation after circulatory death donor lungs categorized by donation after brain death lung criteria." European Journal of Cardio-Thoracic Surgery 60, no. 3 (March 10, 2021): 590–97. http://dx.doi.org/10.1093/ejcts/ezab121.

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Abstract OBJECTIVES Most transplant centres use donation after brain death (DBD) criteria to assess the quality of controlled donation after circulatory death (cDCD) lungs. However, research on the relationship between DBD extended criteria and cDCD lung transplantation outcomes is limited. We investigated the outcomes of using DBD extended criteria donor organs in cDCD lung transplantation, compared to the standard criteria cDCD lung transplantation. METHODS A retrospective chart review of consecutive cDCD lung referrals to Hospital Universitario Puerta de Hierro-Majadahonda from June 2013 to December 2019 was undertaken. Donors were divided into standard and extended criteria groups. Early outcomes after lung transplant were compared between these groups using the Kaplan–Meier method and log-rank test. RESULTS Thirty out of 91 cDCD donor lung offers were accepted for transplantation, of which 11 were from standard criteria donors and 19 were extended criteria donors. The baseline characteristics of the 2 recipient groups were similar. There were no differences in the rates of grade 3 primary graft dysfunction at 72 h after lung transplantation (21% vs 18%), duration of mechanical ventilation (48 h vs 36 h), total intensive care unit stay (10 days vs 7 days) and 1-year survival (89% vs 90%). CONCLUSIONS Carefully selecting cDCD lungs from outside the standard acceptability criteria may expand the existing donor pool with no detrimental effects on lung transplantation outcomes.

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38

Hodgson, R., A. Young, M. Attia, and P. Lodge. "Impact of a National Controlled Donation After Circulatory Death (DCD) Programme on Organ Donation: A 10 Year Study." HPB 21 (2019): S772. http://dx.doi.org/10.1016/j.hpb.2019.10.670.

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39

Hodgson, R., A. Young, M. Attia, and P. Lodge. "Impact of a national controlled donation after circulatory death (DCD) programme on organ donation: a 10 year study." HPB 21 (2019): S1001—S1002. http://dx.doi.org/10.1016/j.hpb.2019.10.1353.

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40

Palomo-López, Nora, Ana Rodríguez-Rodríguez, Luis Martín-Villén, María Mendoza-Prieto, Zaida Ruiz de Azúa-López, Lluis Sempere-Bordes, Laura Boyero-Corral, et al. "Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results." Healthcare 10, no. 5 (April 20, 2022): 762. http://dx.doi.org/10.3390/healthcare10050762.

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The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medical history were collected. We also collected serial measurements of MDA, at 60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE were similar between groups. Although MDA values did not differ in the DBD group, statistical differences were observed in DCD donors during the 0–60 min interval: −4.296 (−6.752; −2.336) in the melatonin group and −1.612 (−2.886; −0.7445) in controls. Given the antioxidant effect of melatonin, its use could reduce the production of oxidative stress in controlled DCD.

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41

Muller, Xavier, Guillaume Rossignol, Kayvan Mohkam, Mickaël Lesurtel, and Jean‐Yves Mabrut. "Dynamic Liver Graft Preservation in Controlled Donation After Circulatory Death: What Is the Best Fit?" Liver Transplantation 28, no. 2 (October 25, 2021): 330–31. http://dx.doi.org/10.1002/lt.26333.

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42

Sanchez, P. G., M. Rouse, D. L. Pratt, Z. N. Kon, R. N. Pierson, K. Rajagopal, A. T. Iacono, S. M. Pham, and B. P. Griffith. "Lung Donation After Controlled Circulatory Determination of Death: A Review of Current Practices and Outcomes." Transplantation Proceedings 47, no. 6 (July 2015): 1958–65. http://dx.doi.org/10.1016/j.transproceed.2015.06.026.

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43

Roldán-Reina, Á. J., J. J. Egea-Guerrero, N. Palomo-López, D. X. Cuenca-Apolo, M. Adriaensens-Pérez, M. Porras-López, Z. Ruiz de Azúa-López, Y. Corcia-Palomo, and L. Martín-Villén. "Postoperative Care in Kidney Transplantation: A Comparison Between Controlled and Uncontrolled Donation After Circulatory Death." Transplantation Proceedings 50, no. 2 (March 2018): 533–35. http://dx.doi.org/10.1016/j.transproceed.2017.11.058.

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44

Okamoto, T., H. Niikawa, C. Tu, S. Unai, A. Zeeshan, U. Ahmad, M. Tong, D. Johnston, M. Budev, and K. R. McCurry. "Single Center Experience of Controlled Donation After Circulatory Death in Lung Transplantation at Cleveland Clinic." Journal of Heart and Lung Transplantation 37, no. 4 (April 2018): S241. http://dx.doi.org/10.1016/j.healun.2018.01.599.

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45

Ledoux, Didier, Marie-Hélène Delbouille, Arnaud Deroover, Bernard Lambermont, Michel Meurisse, Pierre Damas, Jean Joris, and Olivier Detry. "Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?" Clinical Transplantation 28, no. 1 (November 21, 2013): 47–51. http://dx.doi.org/10.1111/ctr.12276.

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46

Ramos, Ana María Bellón, Marta Pérez Calle, Elisa Bueso Inchausti García, Mario Carretero Rodrigo, Ana Amaro Harpigny, Jose Antonio Galiano Gordillo, Sara Alcántara Carmona, and Marina Pérez Redondo. "Succes rate of liver retrieval in normothermic regional perfusion during controlled donation after circulatory death." Journal of Critical Care 81 (June 2024): 154672. http://dx.doi.org/10.1016/j.jcrc.2024.154672.

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47

Magán, María Del Mar Martín, Ramón Mula Martínez, Marta Mateos Llosa, Clara Manso Murcia, Maria Dolores Victoria Ródenas, María Granados Madero, Paula Rivera Sánchez, et al. "Heart transplants from controlled donation after the circulatory determination of death (CDD): Our initial experience." Journal of Critical Care 81 (June 2024): 154588. http://dx.doi.org/10.1016/j.jcrc.2024.154588.

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48

Hessheimer, Amelia J., Elisabeth Coll, Ferrán Torres, Patricia Ruíz, Mikel Gastaca, José Ignacio Rivas, Manuel Gómez, et al. "Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation." Journal of Hepatology 70, no. 4 (April 2019): 658–65. http://dx.doi.org/10.1016/j.jhep.2018.12.013.

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Muller, X., G. Rossignol, S. Damotte, A. Grégoire, E. Morelon, L. Badet, K. Mohkam, M. Lesurtel, and J. Y. Mabrut. "Graft utilization after normothermic regional perfusion in controlled donation after circulatory death - 5-year experience from France." HPB 23 (2021): S770—S772. http://dx.doi.org/10.1016/j.hpb.2021.08.201.

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Kotsopoulos, Angela M. M., Piet Vos, Nichon E. Jansen, Ewald M. Bronkhorst, Johannes G. van der Hoeven, and Wilson F. Abdo. "Prediction Model for Timing of Death in Potential Donors After Circulatory Death (DCD III): Protocol for a Multicenter Prospective Observational Cohort Study." JMIR Research Protocols 9, no. 6 (June 23, 2020): e16733. http://dx.doi.org/10.2196/16733.

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Abstract:

Background Controlled donation after circulatory death (cDCD) is a major source of organs for transplantation. A potential cDCD donor poses considerable challenges in terms of identification of those dying within the predefined time frame of warm ischemia after withdrawal of life-sustaining treatment (WLST) to circulatory arrest. Several attempts have been made to develop models predicting the time between treatment withdrawal and circulatory arrest. This time window determines whether organ donation can occur and influences the quality of the donated organs. However, the selected patients used for these models were not always restricted to potential cDCD donors (eg, patients with cancer or severe infections were also included). This severely limits the generalizability of those data. Objective The objectives of this study are the following: (1) to develop a model predicting time to death within 60 minutes in potential cDCD patients; (2) to validate and update previous prediction models on time to death after WLST; (3) to determine timing and patient characteristics that are associated with prognostication and the decision-making process that leads to initiating end-of-life care; (4) to evaluate the impact of timing of family approach on organ donation approval; and (5) to assess the influence of variation in WLST processes on postmortem organ donor potential and actual postmortem organ donors. Methods In this multicenter observational prospective cohort study, all patients admitted to the intensive care unit of 3 university hospitals and 3 teaching hospitals who met the criteria of the cDCD protocol as defined by the Dutch Transplant Foundation were included. The target of enrolment was set to 400 patients. Previously developed models will be refitted in our data set. To further update previous prediction models, we will apply least absolute shrinkage and selection operator (LASSO) as a tool for efficient variable selection to develop the multivariable logistic regression model. Results This protocol was funded in August 2014 by the Dutch Transplant Foundation. We expect to have the results of this study in July 2020. Patient enrolment was completed in July 2018 and data collection was completed in April 2020. Conclusions This study will provide a robust multimodal prediction model, based on clinical and physiological parameters, that can predict time to circulatory arrest in cDCD donors. In addition, it will add valuable insight in the process of WLST in cDCD donors and will fill an important knowledge gap in this essential field of health care. Trial Registration ClinicalTrials.gov NCT04123275; https://clinicaltrials.gov/ct2/show/NCT04123275 International Registered Report Identifier (IRRID) DERR1-10.2196/16733

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