Academic literature on the topic 'Congreve's late answer to Mr'

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Journal articles on the topic "Congreve's late answer to Mr"

1

Dobson, Barrie. "The Monastic Orders in Late Medieval Cambridge." Studies in Church History. Subsidia 11 (1999): 239–69. http://dx.doi.org/10.1017/s0143045900002301.

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Towards the end of his long career Abbot John Whethamstede, for many years the most celebrated Benedictine monk in England, took the opportunity of a letter he was writing to the prior of Tynemouth to engage in rhetorical but equally eulogistic praise of the ‘extraordinary melodies in praise of the Muses’ to be found not only at ‘the Cabalinian font which gushes forth in the midst of Oxford’ but also from ‘the Cirrean stream which runs near the suburbs of Cambridge’. Few historians of England’s two medieval universities have found it altogether easy to share the undiscriminating enthusiasm of the venerable abbot of St Albans for both Oxford and Cambridge. Gordon Leff — not of course at all alone in this — has done much to elucidate the intellectual and institutional life of the university of Oxford only to find the medieval history of his own university of Cambridge so much less rewarding that it rarely figures in his published work at all. Quite why, for at least the first two centuries of their existence, the Cambridge schools should have always remained less numerically significant and academically influential than their Oxford counterparts is still perhaps a more difficult question to answer than is usually assumed. Even more difficult to explain are the changing patterns of recruitment, patronage, endowment and intellectual activity which during the course of the mid and later fifteenth century at long last eradicated Cambridge’s inferior academic status and established an approximate degree of parity and prestige between the two universities. Without much doubt it was only then, during the century or so before the Reformation, that the historian encounters what Mr Malcolm Underwood has recently diagnosed as perhaps the most remarkable and influential of all ‘Cambridge phenomena’. Indeed if one had to choose a particular point in time when that ‘phenomenon’ must at last have become obvious to all contemporaries, even at Oxford, one might do worse than choose the years between 1505 and 1508, when Lady Margaret Beaufort’s transformation of God’s House into Christ’s College ‘took place against the background of an unprecedented number of royal visits’.* It was on one of those occasions, almost certainly on 22 April 1506, that Henry VII rode towards Cambridge, where ‘within a quarter of a mylle, there stode, first of all the four Ordres of Freres, and after odir Religious, and the King on Horsbacke kyssed the Crosse of everyche of the Religious, and then there stode all along, all the Graduatts, aftir their Degrees, in all their Habbitts, and at the end of them was the Unyversyte Cross’.
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2

Loblaw, Andrew, Patrick Cheung, Danny Vesprini, Stanley K. Liu, William Chu, Hans T. Chung, Gerard Morton, et al. "Stereotactic radiotherapy +/- HDR boost for unfavorable-risk prostate cancer: Comparison of efficacy, survival, and late toxicity outcomes." Journal of Clinical Oncology 38, no. 6_suppl (February 20, 2020): 372. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.372.

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372 Background: The ASCO/CCO guidelines recommend brachytherapy boost for all eligible intermediate- or high-risk localized prostate cancer patients. Stereotactic body radiotherapy (SBRT) is an emerging treatment for prostate cancer but its use in high risk disease is limited. We compare efficacy, survival and late toxicity outcomes in patients treated on 2 prospective, phase 2 protocols that both use pelvic SBRT and androgen deprivation therapy (ADT). One used MR-guided HDR brachytherapy boost (SPARE) and the other uses a SBRT boost (SATURN). Methods: SPARE was a phase I/II study where intermediate (IR) or high-risk (HR) prostate cancer patients received HDR-BT 15Gy x 1 to the prostate and up to 22.5Gy to the MRI nodule and followed by gantry-based SBRT 25Gy in 5 weekly fractions delivered to pelvis. ADT was used for 6-18 months. SATURN was a phase II study where high risk patients received 40Gy to prostate and 25Gy to pelvis along in 5 weekly fractions with 12-18 months ADT. CTCAEv3 was used to assess toxicities and was captured q6months x 5 years. Biochemical failure (BF; nadir + 2 definition), nadir PSA, proportion of patients with PSA < 0.4 ng/ml at 4 years (4yPSARR), incidence of salvage therapy, cause specific survival were calculated. Day 0 was first day of RT for all time-to-event analyses. Results: Thirty-two patients (NCCN 3% favorable IR, 47% unfavorable IR (UIR), 50% HR) completed SPARE while 30 patients (7% UIR, 93% HR) completed SATURN. Median follow-up of 50 and 48 months, respectively. Actuarial 4-year BF was 11.5% and 0%. Median nPSA was 0.02 ng/ml for both studies. 4yPSARR was 69% and 93%. 4-year cause-specific survival was 96% and 100%. Toxicities are listed in Table. Conclusions: In the context of SBRT pelvis and ADT, SBRT boost provides similar efficacy for unfavorable risk prostate cancer with acceptable but worse toxicities compared to HDR boost. A randomized study is recommended to answer this question. Clinical trial information: 01953055. [Table: see text]
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Jefferson, Rebecca. "Dangerous Liaisons in Cairo: Reginald Q. Henriques and the Taylor-Schechter Genizah Manuscript Collection." Judaica Librarianship 20, no. 1 (December 31, 2017): 21–51. http://dx.doi.org/10.14263/2330-2976.1212.

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When Solomon Schechter published his opus magnum, the co-edited volume of The Wisdom of Ben Sira, in 1899, he took the trouble to express his gratitude towards one Reginald Q. Henriques for his help in the past and still ongoing. This article attempts to answer the question: who was this Mr. Henriques and what was the nature of his connection to Schechter? Using previously unpublished archival evidence, this question is explored in depth, as well as the question of why Schechter chose to acknowledge this individual precisely at that point. It also provides an in-depth account, together with transcriptions of original letters, of the activities of the various genizah manuscript collectors operating in Cairo during the late 1890s and the unspoken race to recover the original Hebrew version of the Book of Ben Sira. These activities are viewed against the backdrop of an all-pervasive scholarly culture that was critical of post-biblical Judaism, as well as prevailing Cairene attitudes and behaviors towards those engaged in the recovery and export of antiquities, and the varying (often arbitrary) authorizations and restrictions exercised by Cairo's European and Egyptian administrators. Finally, it takes a closer look at the contents of today's Taylor-Schechter Genizah Collection at Cambridge University Library in an attempt to discover greater details about its exact provenance.
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Moustafa E. Radwan. "Imaging strategy for acute stroke patients, a review of literature." GSC Advanced Research and Reviews 6, no. 1 (January 30, 2021): 037–46. http://dx.doi.org/10.30574/gscarr.2021.6.1.0134.

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Background: This review article focused on the utilization and impact of current neuroimaging techniques for the patient with acute stroke, emphasizing how imaging builds upon clinical assessment to establish diagnosis or etiology and guide therapeutic decisions. When requesting imaging examinations in patients with stroke symptoms; it is crucial to evaluate four significant parameters of stroke; parenchyma, vessels, perfusion, and penumbra. Evaluation of all these four parameters, in their right request are essential to grasp the explanation and potential therapy decisions for stroke in a specific patient. Extensive neurovascular imaging conventions utilizing multimodality CT (NCCT, CT Angiography, and CT Perfusion) or multimodality MRI (DWI-perfusion mismatch or DWI-FLAIR mismatch, and MR Angiography) might be utilized to evaluate the acute stroke patients and provide all the needed data for treatment of them inside minutes after the patient lands at the emergency clinic. Using this approach will help to discriminate between hemorrhagic and ischemic stroke as presence of frank intracerebral hemorrhage contraindicates reperfusion treatment, permits the choice of patients with large vessel occlusion for endovascular treatment and answer the important “tissue clock” within 6 hours from symptom and even with late-presenting (> 6 h) or wake-up stroke. Conclusions: As patients with acute cerebral stroke might be critically ill, the initial imaging scanning for acute stroke patients should be constrained to the procurement of useful data only, considering the accessible therapeutic options at a given place at any given time.
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Busch, A. S., B. Hollis, F. R. Day, K. Sørensen, L. Aksglaede, J. R. B. Perry, K. K. Ong, A. Juul, and C. P. Hagen. "Voice break in boys—temporal relations with other pubertal milestones and likely causal effects of BMI." Human Reproduction 34, no. 8 (July 26, 2019): 1514–22. http://dx.doi.org/10.1093/humrep/dez118.

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Abstract STUDY QUESTION How is timing of voice break related to other male pubertal milestones as well as to BMI? SUMMARY ANSWER We provide a comprehensive temporal analysis of male pubertal milestones, including reproductive hormone dynamics, confirm voice break as a late milestone of male puberty and report a likely causal relationship between higher BMI and earlier age at voice break in men. WHAT IS KNOWN ALREADY Voice break represents a late pubertal milestone and recalled age at voice break is frequently used in epidemiological studies as a measure of puberty. In contrast, clinical studies use mainly testicular enlargement and/or genital tanner stage as the marker of pubertal onset. However, neither correlation of pubertal milestones nor reproductive hormone dynamics have been assessed in detail previously. Further, although BMI and puberty timing are known to be closely linked, cause and effect between these traits are not known. STUDY DESIGN, SIZE, DURATION The study included a population-based mixed cross-sectional and longitudinal cohort (2006–2014, COPENHAGEN Puberty Study) of 730 healthy Danish boys. Data for 55 871 male research participants from the 23andMe study were obtained, including genome-wide single nucleotide polymorphism data and age at voice break. PARTICIPANTS/MATERIALS, SETTING, METHODS We performed a detailed evaluation of pubertal milestones and reproductive hormone levels (study population 1). A Mendelian randomization (MR) approach was used to determine the likely causal link between BMI and timing of voice break (study population 2). MAIN RESULTS AND THE ROLE OF CHANCE Voice break occurred at mean age 13.6 (95% CI: 13.5–13.8) years. At voice break, mean (95% CI) testosterone levels, LH levels and bi-testicular volume were 10.9 (10.0–11.7) nmol/L, 2.4 (2.2–2.5) IU/L and 24 (23–25) mL, respectively. Voice break correlated moderately strongly with timing of male pubertal milestones, including testicular enlargement, gonadarche, pubarche, sweat odor, axillary hair growth and testosterone above limit of detection (r2 range: 0.43–0.61). Timing of all milestones was negatively associated with age-specific BMI (all P ≤ 0.001). MR analyses inferred likely causal effects of higher BMI on earlier voice break in males (−0.35 years/approximate SD, P < 0.001). LIMITATIONS, REASONS FOR CAUTION Participation rate of the population-based cohort was 25%. Further, boys that were followed longitudinally were examined approximately every 6 months limiting the time resolution of pubertal milestones. Using adult BMI as exposure instead of prepubertal BMI in the MR analysis and the known inaccuracies of the testosterone immunoassay at low testosterone levels may be further limitations. WIDER IMPLICATIONS OF THE FINDINGS We provide valuable normative data on the temporal relation of male pubertal milestones. Further, the likely causal relationship between BMI and puberty timing highlights the importance of preventing obesity in childhood. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by Danish Agency for Science, Technology and Innovation (09-067 180); Danish Ministry of the Environment, CeHoS (MST-621-00 065); Capital Region of Denmark (R129-A3966); Ministry of Higher Education and Science (DFF-1331-00 113); Innovation Fund Denmark (InnovationsFonden, 14-2013-4); The International Center for Research and Research Training in Endocrine Disrupting Effects of Male Reproduction and Child Health. B.H., F.R.D., J.R.B.P. and K.K.O. are supported by the Medical Research Council (MC_UU_12015/2). The 23andMe study is supported by the National Human Genome Research Institute of the National Institutes of Health (R44HG006981). Members of the 23andMe Research Team are employees of 23andMe, Inc. and hold stock or stock options in 23andMe. TRIAL REGISTRATION NUMBER NCT01411527
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Hirota, Toshio Fukudand Kaoru. "Message from Editors-in-Chief." Journal of Advanced Computational Intelligence and Intelligent Informatics 1, no. 1 (October 20, 1997): 0. http://dx.doi.org/10.20965/jaciii.1997.p0000.

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We are very pleased and honored to have an opportunity to publish a new journal the "International Journal of Advanced Computational Intelligence" (JACI). The JACI is a new, bimonthly journal covering the field of computer science. This journal focuses on advanced computational intelligence, including the synergetic integration of neural networks, fuzzy logic and evolutionary computations, in order to assist in fostering the application of intelligent systems to industry. This new field is called computational intelligence or soft computing. It has already been studied by many researchers, but no single, integrated journal exists anywhere in the world. This new journal gives readers the state of art of the theory and application of Advanced Computational Intelligence. The Topics include, but are not limited to: Fuzzy Logic, Neural Networks, GA and Evolutionary Computation, Hybrid Systems, Network Systems, Multimedia, the Human Interface, Biologically-Inspired Evolutionary Systems, Artificial Life, Chaos, Fractal, Wavelet Analysis, Scientific Applications and Industrial Applications. The journal, JACI, is supported by many researchers and scientific organizations, e.g., the International Fuzzy Systems Association (IFSA), the Japan Society of Fuzzy Theory and Systems (SOFT), the Brazilian Society of Automatics (SBA) and The Society of Instrument and Control Engineers (SICE), and we are currently negotiating with the John von Neumann Computer Society (in Hungary). Our policy is to have world-wide communication with many societies and researchers in this field. We would appreciate it if those organizations and people who have an interest in co-sponsorship or have proposals for special issues in this journal, as well as paper submissions, could contact us. Finally our special thanks go to the editorial office of Fuji Technology Press Ltd., especially to its president, Mr. K. Hayashi, and to the editor, Mr. Y. Inoue, for their efforts in publishing this new journal. Lotti A. Zadeh The publication of the International Journal of Advanced Computational Intelligence (JACI) is an important milestone in the advancement of our understanding of how intelligent systems can be conceived, designed, built, and deployed. When one first hears of computational intelligence, a question that naturally arises is: What is the difference, if any, between computational intelligence (CI) and artificial intelligence (AI)? As one who has witnessed the births of both AI and CI, I should like to suggest an answer. As a branch of science and technology, artificial intelligence was born about four decades ago. From the outset, AI was based on classical logic and symbol manipulation. Numerical computations were not welcomed and probabilistic techniques were proscribed. Mainstream AI continued to evolve in this spirit, with symbol manipulation still occupying the center of the stage, but not to the degree that it did in the past. Today, probabilistic techniques and neurocomputing are not unwelcome, but the focus is on distributed intelligence, agents, man-machine interfaces, and networking. With the passage of time, it became increasing clear that symbol manipulation is quite limited in its ability to serve as a foundation for the design of intelligent systems, especially in the realms of robotics, computer vision, motion planning, speech recognition, handwriting recognition, fault diagnosis, planning, and related fields. The inability of mainstream AI to live up to expectations in these application areas has led in the mid-eighties to feelings of disenchantment and widespread questioning of the effectiveness of AI's armamentarium. It was at this point that the name computational intelligence was employed by Professor Nick Cercone of Simon Fraser University in British Columbia to start a new journal named Computational Intelligence -a journal that was, and still is, intended to provide a broader conceptual framework for the conception and design of intelligent systems than was provided by mainstream AI. Another important development took place. The concept of soft computing (SC) was introduced in 1990-91 to describe an association of computing methodologies centering on fuzzy logic (FL), neurocomputing (NC), genetic (or evolutionary) computing (GC), and probabilistic computing (PC). In essence, soft computing differs from traditional hard computing in that it is tolerant of imprecision, uncertainty and partial truth. The basic guiding principle of SC is: Exploit the tolerance for imprecision, uncertainty, and partial truth to achieve tractability, robustness, low solution cost, and better rapport with reality. More recently, the concept of computational intelligence had reemerged with a meaning that is substantially different from that which it had in the past. More specifically, in its new sense, CI, like AI, is concerned with the conception, design, and deployment of intelligent systems. However, unlike mainstream AI, CI methodology is based not on predicate logic and symbol manipulation but on the methodologies of soft computing and, more particularly, on fuzzy logic, neurocomputing, genetic(evolutionary) computing, and probabilistic computing. In this sense, computational intelligence and soft computing are closely linked but not identical. In basic ways, the importance of computational intelligence derives in large measure from the effectiveness of the techniques of fuzzy logic, neurocomputing, genetic (evolutionary) computing, and probabilistic computing in the conception and design of information/intelligent systems, as defined in the statements of the aims and scope of the new journal of Advanced Computational Intelligence. There is one important aspect of both computational intelligence and soft computing that should be stressed. The methodologies which lie at the center of CI and SC, namely, FL, NC, genetic (evolutionary) computing, and PC are for the most part complementary and synergistic, rather than competitive. Thus, in many applications, the effectiveness of FL, NC, GC, and PC can be enhanced by employing them in combination, rather than in isolation. Intelligent systems in which FL, NC, GC, and PC are used in combination are frequently referred to as hybrid intelligent systems. Such systems are likely to become the norm in the not distant future. The ubiquity of hybrid intelligent systems is likely to have a profound impact on the ways in which information/intelligent systems are conceived, designed, built, and interacted with. At this juncture, the most visible hybrid intelligent systems are so-called neurofuzzy systems, which are for the most part fuzzy-rule-based systems in which neural network techniques are employed for system identification, rule induction, and tuning. The concept of neurofuzzy systems was originated by Japanese scientists and engineers in the late eighties, and in recent years has found a wide variety of applications, especially in the realms of industrial control, consumer products, and financial engineering. Today, we are beginning to see a widening of the range of applications of computational intelligence centered on the use of neurofuzzy, fuzzy-genetic, neurogenetic, neurochaotic and neuro-fuzzy-genetic systems. The editors-in-chief of Advanced Computational Intelligence, Professors Fukuda and Hirota, have played and are continuing to play majors roles both nationally and internationally in the development of fuzzy logic, soft computing, and computational intelligence. They deserve our thanks and congratulations for conceiving the International Journal of Advanced Computational Intelligence and making it a reality. International in both spirit and practice, JACI is certain to make a major contribution in the years ahead to the advancement of the science and technology of man-made information/intelligence systems -- systems that are at the center of the information revolution, which is having a profound impact on the ways in which we live, communicate, and interact with the real world. Lotfi A. Zadeh Berkeley, CA, July 24, 1997
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Kyrpyta, T. "HERO SEARCHING FOR IDENTITY IN THE ENGLISH LITERATURE OF THE SECOND HALF OF THE XIX CENTURY (ON THE EXAMPLE OF THE WORKS BY J. S. LE FANU AND R. L. STEVENSON)." Fìlologìčnì traktati, 2019, 67–76. http://dx.doi.org/10.21272/ftrk.2019.11(3-4)-8.

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In this article, we aim to examine how English writers of the second half of the nineteenth century attempted to answer the question of the identity of their representative, the way they saw human nature, and the nature of good and evil in a person, in what they saw the integrity of personality, from which the ideals were repelled in search of a hero of his time. Using cultural, historical, and comparative methods, we contrasted the momentous events that influenced nineteenth-century English society with such a literary phenomenon as the revival of interest in the techniques characteristic of the Gothic novel, in particular, characters' doubles, the split personality, expressed through physicality. We have considered the reasons why the idea of the dualism of human nature became relevant in this era. The political, economic and social shifts in the life of England in the second half of the nineteenth century caused the writers to rethink their own identities as representative of nation and humanity. Scientific discoveries, above all, the work of Darwin, forced a new look at the nature of man, his inner world. As a projection of Darwinism as well as the search for self-determination of the colonized peoples, there is a fear of degradation, which is reflected in the appearance of animal characters (the monkey-like ghost in Le Fanu's novel Green Tea, Hyde in the novel by R. L. Stevenson "The Strange Case of Dr. Jekyll and Mr. Hyde"). The literary hero of the late nineteenth century is a multifaceted combination of archetypal images such as Prometheus, Satan, Pygmalion, and the embodiment of the idea of the dualism of human soul, in which the divine and animal principles are combined. Such a split personality is also associated with the destruction of the image of the good patriarch as the embodiment of the English nation. Keywords: Victorian literature, double, duality, rebel hero, identity, Prometheus myth, English "Gothic" tradition.
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Feng, Shenghui, Bangqi Wang, Shen Chen, Qiqi Xie, Lamei Yu, Chaoyi Xiong, Shuang Wang, et al. "Association between proliferative-to-secretory endometrial compaction and pregnancy outcomes after embryo transfer: a systematic review and meta-analysis." Human Reproduction, February 7, 2024. http://dx.doi.org/10.1093/humrep/deae012.

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Abstract STUDY QUESTION Does the change in endometrial thickness (EMT) from the end of the follicular/estrogen phase to the day of embryo transfer (ET) determine subsequent pregnancy outcomes? SUMMARY ANSWER Endometrial compaction from the late-proliferative to secretory phase is not associated with live birth rate (LBR) and other pregnancy outcomes. WHAT IS KNOWN ALREADY Endometrial compaction has been suggested to be indicative of endometrial responsiveness to progesterone, and its association with ET outcome has been investigated but is controversial. STUDY DESIGN, SIZE, DURATION A systematic review with meta-analysis was carried out. PubMed, EMBASE, and Web of Science were searched to identify relevant studies from inception to 18 November 2022. The reference lists of included studies were also manually screened for any additional publications. PARTICIPANTS/MATERIALS, SETTING, METHODS Cohort studies comparing ET pregnancy outcomes between patients with and without endometrial compaction were included. A review of the studies for inclusion, data extraction, and quality assessment was performed by two independent reviewers. The effect size was synthesized as odds ratio (OR) with 95% CI using a random-effects model. Heterogeneity and publication bias were assessed by the I2 statistic and Egger’s test, respectively. The primary outcome was LBR. Secondary outcomes included biochemical pregnancy rate (BPR), clinical pregnancy rate (CPR), miscarriage rate (MR), ongoing pregnancy rate (OPR), and ectopic pregnancy rate (EPR). MAIN RESULTS AND THE ROLE OF CHANCE Seventeen cohort studies involving 18 973 ET cycles fulfilled the eligibility criteria. The pooled results revealed that there were no significant differences between endometrial compaction and non-compaction groups in LBR (crude OR (cOR) = 0.95, 95% CI 0.87–1.04; I2 = 0%; adjusted OR (aOR) = 1.02, 95% CI 0.87–1.19, I2 = 79%), BPR (cOR = 0.93, 95% CI 0.81–1.06; I2 = 0%; aOR = 0.88, 95% CI 0.75–1.03, I2 = 0%), CPR (cOR = 0.98, 95% CI 0.81–1.18; I2 = 70%; aOR = 0.86, 95% CI 0.72–1.02, I2 = 13%), MR (cOR = 1.09, 95% CI 0.90–1.32; I2 = 0%; aOR = 0.91, 95% CI 0.64–1.31; I2 = 0%), and EPR (cOR = 0.70, 95% CI 0.31–1.61; I2 = 61%). The OPR was marginally higher in crude analysis (cOR = 1.48, 95% CI 1.01–2.16; I2 = 81%) among women with compacted endometrium, but was not evident in adjusted results (aOR = 1.36, 95% CI 0.86–2.14; I2 = 84%). Consistently, the pooled estimate of LBR remained comparable in further subgroup and sensitivity analyses according to the degree of compaction (0%, 5%, 10%, 15%, or 20%), type of ET (fresh, frozen, or euploid only), and endometrial preparation protocol (natural or artificial). No publication bias was observed based on Egger’s test. LIMITATIONS, REASONS FOR CAUTION Although the number of included studies is sufficient, data on certain measures, such as EPR, are limited. The inherent bias and residual confounding were also inevitable owing to the observational study design. Furthermore, inconsistent definitions of pregnancy outcomes may affect the accuracy of our pooled analysis. WIDER IMPLICATIONS OF THE FINDINGS Given the lack of prognostic value, assessing endometrial compaction or repeated EMT measurement on the day of ET may not be necessary or warranted. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by Natural Science Foundation of Jiangxi Province (20224BAB216025), National Natural Science Foundation of China (82260315), and Central Funds Guiding the Local Science and Technology Development (20221ZDG020071). The authors have no conflicts of interest to declare. REGISTRATION NUMBER CRD42022384539 (PROSPERO).
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Jiang, Y., M. Saare, M. Wróbel, K. A. Rodriguez-Wallberg, A. Reyes Palomares, K. Kask, A. Kalinina, et al. "P-325 Comparing slow-freezing and vitrification endometrial biopsy cryopreservation protocols for tissue cryodamage and functional organoid formation." Human Reproduction 39, Supplement_1 (July 1, 2024). http://dx.doi.org/10.1093/humrep/deae108.689.

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Abstract Study question Are slow-freezing and vitrification suitable methods for cryopreserving endometrial biopsies intended for downstream research applications and organoid formation? Summary answer Both slow-frozen and vitrified endometrial biopsies resulted in successful organoid formation thus can be considered similar to fresh endometrial biopsies in preserving the cellular viability. What is known already Passive slow freezing (PSF) protocols have demonstrated efficacy for cryopreserving endometrial biopsies with subsequently viable isolated epithelial and stromal cells. Additionally, single-cell transcriptomic analyses and successful generation of endometrial organoids suggest a little impact of cryopreservation. By avoiding ice crystal formation, vitrification (VT) could potentially prevent mechanical injury and improve tissue integrity compared to slow freezing. Study design, size, duration Experimental study using endometrial biopsies collected using a Pipelle from eight healthy volunteers. Samples were retrieved at three cycle phases: proliferative (n = 2), mid-secretory (7 days post-LH surge, LH + 7, n = 2) and late-secretory phase (LH + 11, n = 4). Each biopsy was divided into fresh, slow-freezing and vitrification sub-samples for further comparison of outcomes according to microscopic histological analysis, transmission electron microscopy (TEM), gene expression profiling evaluation and generation of endometrial epithelial organoids (from 2 slow-frozen and 2 vitrified samples). Participants/materials, setting, methods PSF was performed using Mr Frosty with samples embedded in 1x DMEM, 30% FBS and 7.5% DMSO at -80ºC. Vitrification was performed using 40% ethylene glycol (EG); 30% Ficoll; 0.5 M Sucrose and 10 mg/ml HSA, and preserved in liquid nitrogen. Tissue morphology was evaluated by traditional histology, TEM and gene expression profiling. The viability of endometrial cells and the ability to form epithelial organoids were evaluated before and after two different freezing protocols. Main results and the role of chance Our analysis showed that both PSF and vitrification techniques are appropriate for cryopreservation and storage of endometrial biopsies aimed at organoid generation, as no significant differences were found between fresh and cryopreserved tissue samples. However, ultrastructural changes were observed by TEM in PSF samples indicating an impact on mitochondria of epithelial and stromal cells with increased swelling. Changes were also observed in epithelial cells in vitrified samples, with decreased nuclear granularity, clarity, and open karyoplasm. On TEM analyses changes in the chromatin status were more evident in vitrified samples compared to fresh and PSF samples. PSF treated samples showed similarly high quality of epithelial and stromal nuclear staining when compared to the fresh samples in haematoxylin and eosin-stained slides, while VT of samples resulted in a significant decrease of both epithelial and stromal nuclear clarity. However, despite these changes observed in the tissue morphology, all three groups displayed similar transcriptional profiles and endometrial organoids were generated from both slow-frozen and vitrified samples, indicating very little or no impact of the freezing method used for post-thaw tissue functionality. Limitations, reasons for caution Although our study demonstrated relatively mild damages in both freezing protocols, we cannot exclude the absence of additional changes not evaluated in this study, such as those concerning the epigenetic constitution of the cells. Therefore, more extended research with larger sample size is needed for further validation of the results. Wider implications of the findings Our findings indicate that both slow-freezing and vitrification methods applied to endometrial biopsies are effective in maintaining tissue morphology and functionality. Further optimization of cryopreservation methods of endometrium could contribute to future experimental and clinical use of cryopreserved endometrial tissue. Trial registration number not applicable
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McGrath, Shane. "Compassionate Refugee Politics?" M/C Journal 8, no. 6 (December 1, 2005). http://dx.doi.org/10.5204/mcj.2440.

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One of the most distinct places the politics of affect have played out in Australia of late has been in the struggles around the mandatory detention of undocumented migrants; specifically, in arguments about the amount of compassion border control practices should or do entail. Indeed, in 1990 the newly established Joint Standing Committee on Migration (JSCM) published its first report, Illegal Entrants in Australia: Balancing Control and Compassion. Contemporaneous, thought not specifically concerned, with the establishment of mandatory detention for asylum seekers, this report helped shape the context in which detention policy developed. As the Bureau of Immigration and Population Research put it in their summary of the report, “the Committee endorsed a tough stance regarding all future illegal entrants but a more compassionate stance regarding those now in Australia” (24). It would be easy now to frame this report in a narrative of decline. Under a Labor government the JSCM had at least some compassion to offer; since the 1996 conservative Coalition victory any such compassion has been in increasingly short supply, if not an outright political liability. This is a popular narrative for those clinging to the belief that Labor is still, in some residual sense, a social-democratic party. I am more interested in the ways the report’s subtitle effectively predicted the framework in which debates about detention have since been constructed: control vs. compassion, with balance as the appropriate mediating term. Control and compassion are presented as the poles of a single governmental project insofar as they can be properly calibrated; but at the same time, compassion is presented as an external balance to the governmental project (control), an extra-political restriction of the political sphere. This is a very formal way to put it, but it reflects a simple, vernacular theory that circulates widely among refugee activists. It is expressed with concision in Peter Mares’ groundbreaking book on detention centres, Borderlines, in the chapter title “Compassion as a vice”. Compassion remains one of the major themes and demands of Australian refugee advocates. They thematise compassion not only for the obvious reasons that mandatory detention involves a devastating lack thereof, and that its critics are frequently driven by intense emotional connections both to particular detainees and TPV holders and, more generally, to all who suffer the effects of Australian border control. There is also a historical or conjunctural element: as Ghassan Hage has written, for the last ten years or so many forms of political opposition in Australia have organised their criticisms in terms of “things like compassion or hospitality rather than in the name of a left/right political divide” (7). This tendency is not limited to any one group; it ranges across the spectrum from Liberal Party wets to anarchist collectives, via dozens of organised groups and individuals varying greatly in their political beliefs and intentions. In this context, it would be tendentious to offer any particular example(s) of compassionate activism, so let me instead cite a complaint. In November 2002, the conservative journal Quadrant worried that morality and compassion “have been appropriated as if by right by those who are opposed to the government’s policies” on border protection (“False Refugees” 2). Thus, the right was forced to begin to speak the language of compassion as well. The Department of Immigration, often considered the epitome of the lack of compassion in Australian politics, use the phrase “Australia is a compassionate country, but…” so often they might as well inscribe it on their letterhead. Of course this is hypocritical, but it is not enough to say the right are deforming the true meaning of the term. The point is that compassion is a contested term in Australian political discourse; its meanings are not fixed, but constructed and struggled over by competing political interests. This should not be particularly surprising. Stuart Hall, following Ernesto Laclau and others, famously argued that no political term has an intrinsic meaning. Meanings are produced – articulated, and de- or re-articulated – through a dynamic and partisan “suturing together of elements that have no necessary or eternal belongingness” (10). Compassion has many possible political meanings; it can be articulated to diverse social (and antisocial) ends. If I was writing on the politics of compassion in the US, for example, I would be talking about George W. Bush’s slogan of “compassionate conservatism”, and whatever Hannah Arendt meant when she argued that “the passion of compassion has haunted and driven the best men [sic] of all revolutions” (65), I think she meant something very different by the term than do, say, Rural Australians for Refugees. As Lauren Berlant has written, “politicized feeling is a kind of thinking that too often assumes the obviousness of the thought it has” (48). Hage has also opened this assumed obviousness to question, writing that “small-‘l’ liberals often translate the social conditions that allow them to hold certain superior ethical views into a kind of innate moral superiority. They see ethics as a matter of will” (8-9). These social conditions are complex – it isn’t just that, as some on the right like to assert, compassion is a product of middle class comfort. The actual relations are more dynamic and open. Connections between class and occupational categories on the one hand, and social attitudes and values on the other, are not given but constructed, articulated and struggled over. As Hall put it, the way class functions in the distribution of ideologies is “not as the permanent class-colonization of a discourse, but as the work entailed in articulating these discourses to different political class practices” (139). The point here is to emphasise that the politics of compassion are not straightforward, and that we can recognise and affirm feelings of compassion while questioning the politics that seem to emanate from those feelings. For example, a politics that takes compassion as its basis seems ill-suited to think through issues it can’t put a human face to – that is, the systematic and structural conditions for mandatory detention and border control. Compassion’s political investments accrue to specifiable individuals and groups, and to the harms done to them. This is not, as such, a bad thing, particularly if you happen to be a specifiable individual to whom a substantive harm has been done. But compassion, going one by one, group by group, doesn’t cope well with situations where the form of the one, or the form of the disadvantaged minority, constitutes not only a basis for aid or emancipation, but also violently imposes particular ideas of modern western subjectivity. How does this violence work? I want to answer by way of the story of an Iranian man who applied for asylum in Australia in 2004. In the available documents he is referred to as “the Applicant”. The Applicant claimed asylum based on his homosexuality, and his fear of persecution should he return to Iran. His asylum application was rejected by the Refugee Review Tribunal because the Tribunal did not believe he was really gay. In their decision they write that “the Tribunal was surprised to observe such a comprehensive inability on the Applicant’s part to identify any kind of emotion-stirring or dignity-arousing phenomena in the world around him”. The phenomena the Tribunal suggest might have been emotion-stirring for a gay Iranian include Oscar Wilde, Alexander the Great, Andre Gide, Greco-Roman wrestling, Bette Midler, and Madonna. I can personally think of much worse bases for immigration decisions than Madonna fandom, but there is obviously something more at stake here. (All quotes from the hearing are taken from the High Court transcript “WAAG v MIMIA”. I have been unable to locate a transcript of the original RRT decision, and so far as I know it remains unavailable. Thanks to Mark Pendleton for drawing my attention to this case, and for help with references.) Justice Kirby, one of the presiding Justices at the Applicant’s High Court appeal, responded to this with the obvious point, “Madonna, Bette Midler and so on are phenomena of the Western culture. In Iran, where there is death for some people who are homosexuals, these are not in the forefront of the mind”. Indeed, the High Court is repeatedly critical and even scornful of the Tribunal decision. When Mr Bennett, who is appearing for the Minister for Immigration in the appeal begins his case, he says, “your Honour, the primary attack which seems to be made on the decision of the –”, he is cut off by Justice Gummow, who says, “Well, in lay terms, the primary attack is that it was botched in the Tribunal, Mr Solicitor”. But Mr Bennett replies by saying no, “it was not botched. If one reads the whole of the Tribunal judgement, one sees a consistent line of reasoning and a conclusion being reached”. In a sense this is true; the deep tragicomic weirdness of the Tribunal decision is based very much in the unfolding of a particular form of homophobic rationality specific to border control and refugee determination. There have been hundreds of applications for protection specifically from homophobic persecution since 1994, when the first such application was made in Australia. As of 2002, only 22% of those applications had been successful, with the odds stacked heavily against lesbians – only 7% of lesbian applicants were successful, against a shocking enough 26% of gay men (Millbank, Imagining Otherness 148). There are a number of reasons for this. The Tribunal has routinely decided that even if persecution had occurred on the basis of homosexuality, the Applicant would be able to avoid such persecution if she or he acted ‘discreetly’, that is, hid their sexuality. The High Court ruled out this argument in 2003, but the Tribunal maintains an array of effective techniques of homophobic exclusion. For example, the Tribunal often uses the Spartacus International Gay Guide to find out about local conditions of lesbian and gay life even though it is a tourist guide book aimed at Western gay men with plenty of disposable income (Dauvergne and Millbank 178-9). And even in cases which have found in favour of particular lesbian and gay asylum seekers, the Tribunal has often gone out of its way to assert that lesbians and gay men are, nevertheless, not the subjects of human rights. States, that is, violate no rights when they legislate against lesbian and gay identities and practices, and the victims of such legislation have no rights to protection (Millbank, Fear 252-3). To go back to Madonna. Bennett’s basic point with respect to the references to the Material Girl et al is that the Tribunal specifically rules them as irrelevant. Mr Bennett: The criticism which is being made concerns a question which the Tribunal asked and what is very much treated in the Tribunal’s judgement as a passing reference. If one looks, for example, at page 34 – Kirby J: This is where Oscar, Alexander and Bette as well as Madonna turn up? Mr Bennett: Yes. The very paragraph my learned friend relies on, if one reads the sentence, what the Tribunal is saying is, “I am not looking for these things”. Gummow J: Well, why mention it? What sort of training do these people get in decision making before they are appointed to this body, Mr Solicitor? Mr Bennett: I cannot assist your Honour on that. Gummow J: No. Well, whatever it is, what happened here does not speak highly of the results of it. To gloss this, Bennett argues that the High Court are making too much of an irrelevant minor point in the decision. Mr Bennett: One would think [based on the High Court’s questions] that the only things in this judgement were the throwaway references saying, “I wasn’t looking for an understanding of Oscar Wilde”, et cetera. That is simply, when one reads the judgement as a whole, not something which goes to the centre at all… There is a small part of the judgement which could be criticized and which is put, in the judgement itself, as a subsidiary element and prefaced with the word “not”. Kirby J: But the “not” is a bit undone by what follows when I think Marilyn [Monroe] is thrown in. Mr Bennett: Well, your Honour, I am not sure why she is thrown in. Kirby J: Well, that is exactly the point. Mr Bennett holds that, as per Wayne’s World, the word “not” negates any clause to which it is attached. Justice Kirby, on the other hand, feels that this “not” comes undone, and that this undoing – and the uncertainty that accrues to it – is exactly the point. But the Tribunal won’t be tied down on this, and makes use of its “not” to hold gay stereotypes at arm’s length – which is still, of course, to hold them, at a remove that will insulate homophobia against its own illegitimacy. The Tribunal defends itself against accusations of homophobia by announcing specifically and repeatedly, in terms that consciously evoke culturally specific gay stereotypes, that it is not interested in those stereotypes. This unconvincing alibi works to prevent any inconvenient accusations of bias from butting in on the routine business of heteronormativity. Paul Morrison has noted that not many people will refuse to believe you’re gay: “Claims to normativity are characteristically met with scepticism. Only parents doubt confessions of deviance” (5). In this case, it is not a parent but a paternalistic state apparatus. The reasons the Tribunal did not believe the applicant [were] (a) because of “inconsistencies about the first sexual experience”, (b) “the uniformity of relationships”, (c) the “absence of a “gay” circle of friends”, (d) “lack of contact with the “gay” underground” and [(e)] “lack of other forms of identification”. Of these the most telling, I think, are the last three: a lack of gay friends, of contact with the gay underground, or of unspecified other forms of identification. What we can see here is that even if the Tribunal isn’t looking for the stereotypical icons of Western gay culture, it is looking for the characteristic forms of Western gay identity which, as we know, are far from universal. The assumptions about the continuities between sex acts and identities that we codify with names like lesbian, gay, homosexual and so on, often very poorly translate the ways in which non-Western populations understand and describe themselves, if they translate them at all. Gayatri Gopinath, for example, uses the term “queer diaspor[a]... in contradistinction to the globalization of “gay” identity that replicates a colonial narrative of development and progress that judges all other sexual cultures, communities, and practices against a model of Euro-American sexual identity” (11). I can’t assess the accuracy of the Tribunal’s claims regarding the Applicant’s social life, although I am inclined to scepticism. But if the Applicant in this case indeed had no gay friends, no contact with the gay underground and no other forms of identification with the big bad world of gaydom, he may obviously, nevertheless, have been a Man Who Has Sex With Men, as they sometimes say in AIDS prevention work. But this would not, either in the terms of Australian law or the UN Convention, qualify him as a refugee. You can only achieve refugee status under the terms of the Convention based on membership of a ‘specific social group’. Lesbians and gay men are held to constitute such groups, but what this means is that there’s a certain forcing of Western identity norms onto the identity and onto the body of the sexual other. This shouldn’t read simply as a moral point about how we should respect diversity. There’s a real sense that our own lives as political and sexual beings are radically impoverished to the extent we fail to foster and affirm non-Western non-heterosexualities. There’s a sustaining enrichment that we miss out on, of course, in addition to the much more serious forms of violence others will be subject to. And these are kinds of violence as well as forms of enrichment that compassionate politics, organised around the good refugee, just does not apprehend. In an essay on “The politics of bad feeling”, Sara Ahmed makes a related argument about national shame and mourning. “Words cannot be separated from bodies, or other signs of life. So the word ‘mourns’ might get attached to some subjects (some more than others represent the nation in mourning), and it might get attached to some objects (some losses more than others may count as losses for this nation)” (73). At one level, these points are often made with regard to compassion, especially as it is racialised in Australian politics; for example, that there would be a public outcry were we to detain hypothetical white boat people. But Ahmed’s point stretches further – in the necessary relation between words and bodies, she asks not only which bodies do the describing and which are described, but which are permitted a relation to language at all? If “words cannot be separated from bodies”, what happens to those bodies words fail? The queer diasporic body, so reductively captured in that phrase, is a case in point. How do we honour its singularity, as well as its sociality? How do we understand the systematicity of the forces that degrade and subjugate it? What do the politics of compassion have to offer here? It’s easy for the critic or the cynic to sneer at such politics – so liberal, so sentimental, so wet – or to deconstruct them, expose “the violence of sentimentality” (Berlant 62), show “how compassion towards the other’s suffering might sustain the violence of appropriation” (Ahmed 74). These are not moves I want to make. A guiding assumption of this essay is that there is never a unilinear trajectory between feelings and politics. Any particular affect or set of affects may be progressive, reactionary, apolitical, or a combination thereof, in a given situation; compassionate politics are no more necessarily bad than they are necessarily good. On the other hand, “not necessarily bad” is a weak basis for a political movement, especially one that needs to understand and negotiate the ways the enclosures and borders of late capitalism mass-produce bodies we can’t put names to, people outside familiar and recognisable forms of identity and subjectivity. As Etienne Balibar has put it, “in utter disregard of certain borders – or, in certain cases, under covers of such borders – indefinable and impossible identities emerge in various places, identities which are, as a consequence, regarded as non-identities. However, their existence is, none the less, a life-and-death question for large numbers of human beings” (77). Any answer to that question starts with our compassion – and our rage – at an unacceptable situation. But it doesn’t end there. References Ahmed, Sara. “The Politics of Bad Feeling.” Australian Critical Race and Whiteness Studies Association Journal 1.1 (2005): 72-85. Arendt, Hannah. On Revolution. Harmondsworth: Penguin, 1973. Balibar, Etienne. We, the People of Europe? Reflections on Transnational Citizenship. Trans. James Swenson. Princeton: Princeton UP, 2004. Berlant, Lauren. “The Subject of True Feeling: Pain, Privacy and Politics.” Cultural Studies and Political Theory. Ed. Jodi Dean. Ithaca and Cornell: Cornell UP, 2000. 42-62. Bureau of Immigration and Population Research. Illegal Entrants in Australia: An Annotated Bibliography. Canberra: Australian Government Publishing Service, 1994. Dauvergne, Catherine and Jenni Millbank. “Cruisingforsex.com: An Empirical Critique of the Evidentiary Practices of the Australian Refugee Review Tribunal.” Alternative Law Journal 28 (2003): 176-81. “False Refugees and Misplaced Compassion” Editorial. Quadrant 390 (2002): 2-4. Hage, Ghassan. Against Paranoid Nationalism: Searching for Hope in a Shrinking Society. Annandale: Pluto, 2003. Hall, Stuart. The Hard Road to Renewal: Thatcherism and the Crisis of the Left. London: Verso, 1988. Joint Standing Committee on Migration. Illegal Entrants in Australia: Balancing Control and Compassion. Canberra: The Committee, 1990. Mares, Peter. Borderline: Australia’s Treatment of Refugees and Asylum Seekers. Sydney: UNSW Press, 2001. Millbank, Jenni. “Imagining Otherness: Refugee Claims on the Basis of Sexuality in Canada and Australia.” Melbourne University Law Review 26 (2002): 144-77. ———. “Fear of Persecution or Just a Queer Feeling? Refugee Status and Sexual orientation in Australia.” Alternative Law Journal 20 (1995): 261-65, 299. Morrison, Paul. The Explanation for Everything: Essays on Sexual Subjectivity. New York: New York UP, 2001. Pendleton, Mark. “Borderline.” Bite 2 (2004): 3-4. “WAAG v MIMIA [2004]. HCATrans 475 (19 Nov. 2004)” High Court of Australia Transcripts. 2005. 17 Oct. 2005 http://www.austlii.edu.au/au/other/HCATrans/2004/475.html>. Citation reference for this article MLA Style McGrath, Shane. "Compassionate Refugee Politics?." M/C Journal 8.6 (2005). echo date('d M. Y'); ?> <http://journal.media-culture.org.au/0512/02-mcgrath.php>. APA Style McGrath, S. (Dec. 2005) "Compassionate Refugee Politics?," M/C Journal, 8(6). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0512/02-mcgrath.php>.
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Books on the topic "Congreve's late answer to Mr"

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Stillingfleet, Edward. The Bishop of Worcester's Answer to Mr. Locke's Letter, concerning some passages relating to his Essay of humane understanding, mention'd in the late Discourse in vindication of the Trinity. With a postscript in answer to some reflections on that treatise in a late Socinian pamphlet. Alexandria, VA: Alexander Street Press, 2003.

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1569-1641, Fisher John, ed. A relation of the conference between William Laud, late Lord Archbishop of Canterbury and Mr. Fisher the Jesuit by the command of King James of ever blessed memory: With an answer to such exceptions as A.C. takes against it. London: Macmillan, 1986.

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The Stage acquitted: Being a full answer to Mr. Collier and the other enemies of the drama, with a vindication of King Charles the martyr, and the clergy of the Church of England, from the abuses of a scurrilous book called The stage condemned : to which is added, the character of the animadverter, and the animadversions on Mr. Congreve's answer to Mr. Collier. London: Printed for John Barnes ... and sold by M. Gilliflower ... D. Brown ... and R. Parker ..., 1985.

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Warder, Joseph. A Vindication of Joseph Warder, Physician at Croydon; And of Charles Bowen, ... Wherein Mr. Mill's Calumnies, Cast Upon Them in His Late Book, ... Answer to Mr. Pillonniere, &c. Are Confuted;. Gale Ecco, Print Editions, 2018.

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Towers, Joseph. A Letter to the Rev. Mr. John Wesley; In Answer to His Late Pamphlet, Entitled, Free Thoughts on the Present State of Public Affairs. Gale Ecco, Print Editions, 2018.

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Calvinisticus. A Friendly Reproof to a Country Clergyman: For His Answer to the Late Rev. Mr. Hervey's Letters in Vindication of His Theron and Aspasio. Gale Ecco, Print Editions, 2018.

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Arnall, William. Observations on a Pamphlet, Intitled, An Answer to one Part of a Late Infamous Libel, &c. In a Letter to Mr. P. The Second Edition. Gale ECCO, Print Editions, 2018.

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Meares, John. An answer to Mr. George Dixon, late Commander of the Queen Charlotte, in the service of Messrs. Etches and Company; by John Meares, Esq. In which the Remarks of Mr. Dixon ... are ... refuted. Gale ECCO, Print Editions, 2010.

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Eleven Letters from the Late Rev. Mr. Hervey to the Rev. Mr. John Wesley, Containing an Answer to That Gentleman's Remarks on Theron and Aspano: Published from the Authors Manuscript with a Preface. HardPress, 2020.

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Dalrymple, James. A Vindication of the Ecclesiastical Part of Sir James Dalrymple's Historical Collections: In Answer to a Late Pamphlet, Intituled, The Life of the Reverend Mr. John Sage,. Gale ECCO, Print Editions, 2018.

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