Academic literature on the topic 'Concepts' uptake'
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Journal articles on the topic "Concepts' uptake"
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Rein, A., C. N. Legind, and S. Trapp. "New concepts for dynamic plant uptake models." SAR and QSAR in Environmental Research 22, no. 1-2 (January 1, 2011): 191–215. http://dx.doi.org/10.1080/1062936x.2010.548829.
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Nicklin, Stephen, and Klara Miller. "Intestinal uptake and immunological effects of carrageenan—current concepts." Food Additives and Contaminants 6, no. 4 (October 1989): 425–36. http://dx.doi.org/10.1080/02652038909373801.
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Lajtha, Abel. "Developing concepts of cerebral amino acid uptake 1950–1970." Neurochemistry International 14, no. 3 (January 1989): 235–42. http://dx.doi.org/10.1016/0197-0186(89)90049-1.
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Sorrentino, Dario, Wolfgang Stremmel, and Paul D. Berk. "The hepatocellular uptake of bilirubin: Current concepts and controversies." Molecular Aspects of Medicine 9, no. 5 (January 1987): 405–28. http://dx.doi.org/10.1016/0098-2997(87)90006-9.
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Senior, M. L., S. J. New, A. C. Gatrell, and B. J. Francis. "Geographic Influences on the Uptake of Infant Immunisations: 1. Concepts, Models, and Aggregate Analyses." Environment and Planning A: Economy and Space 25, no. 3 (March 1993): 425–36. http://dx.doi.org/10.1068/a250425.
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This is the first of two papers in which the effects on the uptake of immunisation of transport, time—space, and gender-role constraints, among a wider range of influences, are assessed statistically. A critique of a paper by Jarman et al leads to the formulation of an improved conceptual and statistical framework for analyses of uptake. Within this framework, the possibility of explaining immunisation uptake by using readily available data at the District Health Authority scale is reevaluated. Results suggest that analyses solely at this highly aggregate scale are plagued by the statistical problem of overdispersion, and cannot provide reliable explanations of uptake. Rather, it is argued, disaggregate or, preferably, multilevel analyses are required. Such analyses form the subject matter of the second paper.
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Johnsen, Doris, Frederik Vorholt, Jan-Hinrich Gieschen, Beate Müller, and Annette Randhahn. "Electric Mobility and Smart Mobility Concepts—Restrained Uptake in German Cities." World Electric Vehicle Journal 10, no. 4 (November 19, 2019): 81. http://dx.doi.org/10.3390/wevj10040081.
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Ninety German cities exceeded the European threshold on NO2 in 2016, 65 of those cities developed countermeasures and strategies that were published in Green City Plans (GCP). In the scope of this study, 55 publicly available GCPs were evaluated in order to assess their potential for traffic turnaround at a municipal level. All GCPs were analyzed to determine in which of the mentioned five to seven fields of action the respective city had planned measures and which fields of action were prioritized. A more in-depth qualitative analysis of the main topics: Electric mobility, public transport, and mobility concepts was carried out. To get a better understanding of the potential impact of the measures elaborated in the GCPs, complementary information on municipal fleet vehicle stocks, requirements of charging infrastructure for public buses and results of the European roadmap on mobility concepts are given. The evaluation of the GCPs showed that to this day, city administrations mainly optimize the current system by measures of electrification and digitization. Electrification of municipal fleets, car-sharing fleets, and public transport buses is in the focus of the strategies. Instruments to increase non-motorised transport, sustainable commercial transport, and/or mobility concepts are mentioned, but play a minor role. However, there still has been no system change in Germany. Therefore, a substantial turnaround of the transport system (“Verkehrswende”) is necessary. This applies to integrated urban and transport planning, flexible, strong, fast PT, non-motorised and flexible operating systems.
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Baravikova, Aliaksandra. "The uptake of new concepts in urban greening: Insights from Poland." Urban Forestry & Urban Greening 56 (December 2020): 126798. http://dx.doi.org/10.1016/j.ufug.2020.126798.
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Donahue, Nathan D., Handan Acar, and Stefan Wilhelm. "Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine." Advanced Drug Delivery Reviews 143 (March 2019): 68–96. http://dx.doi.org/10.1016/j.addr.2019.04.008.
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van Dommelen, Anne, René de Mot, and Jos Vanderleyden. "Ammonium transport: unifying concepts and unique aspects." Functional Plant Biology 28, no. 9 (2001): 959. http://dx.doi.org/10.1071/pp01070.
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This paper originates from an address at the 8th International Symposium on Nitrogen Fixation with Non-Legumes, Sydney, NSW, December 2000 Ammonium uptake by cells has been studied for more than a century, but only recently a family of ammonium transporters (Mep/Amt) with 10–12 transmembrane domains has been defined. These proteins are probably ubiquitous, since homologues have been found in the major kingdoms of living organisms. Plants as well as yeast and some archaebacteria have multiple Mep/Amt paralogues, which can be distinguished by their affinity for ammonium and the ammonium analogue methylammonium. Most ammonium transporters are induced in nitrogen-starving conditions, both in prokaryotes and plants. In Saccharomyces cerevisiae, Escherichia coli and Azospirillum brasilense Mep/Amt proteins where shown to be necessary for growth when the external concentration of the diffusive ammonium form (NH3) becomes limiting. Ammonium transporters also play an important role in pseudohyphal differentiation in yeast and efficient symbiotic interaction between Rhizobium etli and its host plant. In most bacteria, NH4+ transport appears to be a uniport mechanism driven by the membrane potential, but, depending on the organism, a different mode of ammonium uptake may be operating. Current knowledge offers the basis to investigate further the physiological role of ammonium transporters in the natural habitat of organisms and their importance in plant–bacteria interactions.
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Jarvis, N. J. "Simple physics-based models of compensatory plant water uptake: concepts and eco-hydrological consequences." Hydrology and Earth System Sciences 15, no. 11 (November 16, 2011): 3431–46. http://dx.doi.org/10.5194/hess-15-3431-2011.
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Abstract. Many land surface schemes and simulation models of plant growth designed for practical use employ simple empirical sub-models of root water uptake that cannot adequately reflect the critical role water uptake from sparsely rooted deep subsoil plays in meeting atmospheric transpiration demand in water-limited environments, especially in the presence of shallow groundwater. A failure to account for this so-called "compensatory" water uptake may have serious consequences for both local and global modeling of water and energy fluxes, carbon balances and climate. Some purely empirical compensatory root water uptake models have been proposed, but they are of limited use in global modeling exercises since their parameters cannot be related to measurable soil and vegetation properties. A parsimonious physics-based model of uptake compensation has been developed that requires no more parameters than empirical approaches. This model is described and some aspects of its behavior are illustrated with the help of example simulations. These analyses demonstrate that hydraulic lift can be considered as an extreme form of compensation and that the degree of compensation is principally a function of soil capillarity and the ratio of total effective root length to potential transpiration. Thus, uptake compensation increases as root to leaf area ratios increase, since potential transpiration depends on leaf area. Results of "scenario" simulations for two case studies, one at the local scale (riparian vegetation growing above shallow water tables in seasonally dry or arid climates) and one at a global scale (water balances across an aridity gradient in the continental USA), are presented to illustrate biases in model predictions that arise when water uptake compensation is neglected. In the first case, it is shown that only a compensated model can match the strong relationships between water table depth and leaf area and transpiration observed in riparian forest ecosystems, where sparse roots in the capillary fringe contribute a significant proportion of the water uptake during extended dry periods. The results of the second case study suggest that uncompensated models may give biased estimates of long-term evapotranspiration at the continental scale. In the example presented here, the uncompensated model underestimated total evapotranspiration by 5–7% in climates of intermediate aridity, while the ratio of transpiration to evaporation was also smaller than for the compensated model, especially in arid climates. It is concluded that the parsimonious physics-based model concepts described here may be useful in the context of eco-hydrological modeling at local, regional and global scales.
Dissertations / Theses on the topic "Concepts' uptake"
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Wood, Daniel M. "Assessment of maximal oxygen uptake in runners : new concepts on an old theme." Thesis, University of Chichester, 1999. http://eprints.chi.ac.uk/939/.
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This thesis aimed to establish why the incidence of a V02-plateau is typically high (>80%) for a discontinuous test but not for a continuous test, how treadmill grade influences V02peak and the incidence of a V02-plateau for a speed incremented test, and whether it is possible to develop a continuous protocol for which the incidence of a plateau in the V02-running speed relationship is >80%. Study 1 was a large study that addressed several issues. Each subject (n = 10) completed a discontinuous test (DCT) in which running speed was increased every 3 min, a continuous test in which the speed was increased every 3 min (CT), a ramp test in which the speed was increased every 5 s (5%RT60), and a run to exhaustion at a.speed calculated to elicit 105% V02 peak (105%T). For each test, the treadmill grade was set at 5%, and the sampling period was set at 60 s. Each subject also completed 2 further tests: a ramp test (5% grade) for which the sampling period was 30 s (5%RT30); and a ramp test (60 s samples) for which the treadmill grade was set at 0% (O%RT). The peak V02 (mean ± SD) was higher for the 5%RT60 than for the DCT (59.9 ± 7.9 vs. 57.8 ± 8.1 ml.1 kg·.1 min; p < 0.05), but the incidence of a V02-plateau was higher for the DCT (80% vs. 50%). The incidence of a plateau was also higher for the 5%RT60 than for the O%RT (50% vs. 30%), as was the peak V02 (59.9 ± 7.9 vs. 57.8 ± 7.9 rnl.kg·1.min·1; p = 0.003). The peak V02 was lower for the 105% T than for the 5%RT60, and the difference between the two values was negatively correlated with the duration of the 105%T (r = -0.89, p = 0.001). The incidence of a plateau was lower for the 5%RT30 than for the 5%RT60 (20% vs. 50%); the reason for this appeared to be that the variability in V02 was higher for the 30 s samples. It was concluded that discontinuous tests should not be used for the assessment of V02m", and that factors which influence the variability in V02 might be important determinants of the incidence of a plateau. Study 2 evaluated the effect of sampling period and exercise intensity on the variability in V02. Eight subjects completed 4 runs at -70% V02P" during which 12 samples of expirate were taken over periods 000, 60, 90, or 120 s. In addition, V02 was determined over twelve 30 s periods during runs at -70 and -96% V02Peak (n = 6). The SD for V02 decreased as sampling period increased from 30 to 60 s (1.3 ± 0.7 vs. 0.6 ± 0.2 ml.kg·1.min·1; p < 0.05), but no further decrease was observed as the sampling period increased beyond 60 s. This SD also decreased as exercise intensity increased (1.1 ± 0.2 vs. 0.6 ± 0.3 ml.kg·1.min·1; p = 0.005), such that the SD for 30 s samples taken during the run at -96% was the same as that for the 60 s samples taken at -70% V02Peak (P = 0.96). It was concluded that the only valid approach to defining a V02-plateau is one in which the sampling period decreases as exercise intensity increases. Study 3 evaluated three ramp tests for the assessment of V02max in runners. Each subject (n = 12) completed 3 tests: a constant speed, increasing grade test (lOT); a constant grade, increasing speed test on a level treadmill (0% T); and a constant grade, increasing speed test conducted at a 5% grade (5% T). For each test, the sampling period decreased as the exercise intensity increased and the individual V02 data were fit to both a linear model and a (two-piece) plateau model. For each test, the SEE was lower for the plateau model than for the linear model (p < 0.0005) and a V02-piateau was observed in >90% of subjects. However, V02max, was higher for the 5%T (64.0 ± 4.7 ml.kg·1.min·1) than for the O%T (62.6 ± 4.6 rnl.kg·1.min·1), and higher still for the lOT (65.1 ± 4.3 ml.kg·1min·1) (p < 0.05). It was concluded that whilst an upper limit for V02 is typically reached when trained runners perform a treadmill ramp test, the V02 at which this limit is reached depends on the conditions under which the test is performed.
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McGowan, Susannah Thacker. "Embedding Threshold Concepts in a Large Lecture Course| An Examination of Uptake of Disciplinary Actions." Thesis, University of California, Santa Barbara, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3637449.
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Research in teaching and learning in higher education in the last fifteen years addresses the importance of integrating disciplinary ways of thinking – i.e. an understanding of the ways that questions are asked and investigated within disciplines -- in undergraduate courses. However, the application of this emergent research varies in history departments and in large lecture survey courses. This study addresses the gap in research about effective modes for introducing disciplinary thinking in a large lecture history course through the means of the threshold concepts framework. This dissertation contributes to three areas of research in higher education: application of threshold concepts at the course level; what this application looks like in terms of practices at the discussion section level; and the role of the teaching assistant in his or her own development in teaching history and within the discipline.
This study looked at how threshold concepts were introduced in a large lecture history course. The analytical framework for viewing the results provided a lens to look at how the concepts were introduced and carried throughout the course. This framework, shaped by the situated learning and threshold concepts literature, looked at the "careers" of the concepts and how they were woven through a large learning system from professor to TAs to students.
In order for the careers of the concepts to carry through the course, certain teaching capabilities need to be in place to ensure the concepts reach students. The methods used to determine the uptake of concepts in the TA discussion sections were classroom observations, online surveys and interviews. Results show that teaching assistants are a crucial link for the careers of the concepts within a large lecture course. Moreover, teaching assistants' orientation to threshold concepts contribute to an explicit emphasis on the disciplinary concepts within their own work as disciplinarians and researchers. Tracing the careers of these concepts yielded more information about what is needed within the large course system in terms of the types of processes that need to be in place to support the inclusion of the concepts in the course. Threshold concepts afford faculty an opportunity to rethink the goals and principles that drive their course. Translation and framing of these concepts represented the threshold capabilities needed on the part of the teachers (both the professor and TAs) to support the movement of concepts from professor to students. The historical thinking strategies, such as analyzing primary sources, represented the particular threshold actions needed to support students in moving through thresholds to the discipline. While this is a baseline qualitative study of one large lecture course at UCSB, implications of this work contribute to graduate student teaching development and threshold concept course design.
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BARAVIKOVA, ALIAKSANDRA. "Dealing with conceptual ambiguity on the ground: how practitioners in Europe operationalise the international policy rhetoric on urban climate adaptation." Doctoral thesis, Gran Sasso Science Institute, 2020. http://hdl.handle.net/20.500.12571/9962.
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In recent decades, adaptation to the impacts of climate change has become a key
agenda for cities around the globe. A growing body of literature has already
illustrated how cities are a key driver of climate change, its main victim and a
promising site for action. Meanwhile, climate change has brought not only new
responsibilities but also a new lexicon for urban practitioners. Concepts such as
urban climate resilience and the idea of nature’s benefits for climate adaptation,
embodied in the “green concepts” – nature-based solutions (NbS), ecosystem-based
adaptation (EbA) and blue-green infrastructure (BGI) – feature in the major global
agreements. Still, they are often seen as vague, ambiguous, and therefore of limited
practical value. Despite their prominence both in academia and policy discourses,
their actual operationalisation and use on the ground remains understudied.
This thesis aims to widen the existing scholarly knowledge by examining how urban
climate resilience and ‘green concepts’ are used and operationalised at different
levels of decision-making in the EU. Several bodies of literature contribute to the
conceptual framework of the thesis: climate change adaptation in cities, scholarship
specifically on these concepts, and studies on the role of framings and science-policy
interface in environmental and climate governance. I use qualitative methods
to analyse strategic policy papers and semi-structured interviews with city
practitioners across Europe, plus a survey among European academics.
The thesis is composed of three academic papers investigating the uptake of these
concepts. Paper 1 compares the perceptions of conceptual tensions surrounding
urban resilience among the EU academics and practitioners; Paper 2 looks at how
urban resilience is operationalised in three science-policy projects financed by the
EU; Paper 3 studies the uptake of NbS, BGI and EbA, which are seen as one of the
key ways to enhance urban resilience, in urban green planning and management in
four large Polish cities.
This study provides a critical discussion of concepts’ operationalisation efforts and
challenges and discusses the role of vagueness and uncertainty in their uptake. It
contributes to the literature by expanding the geography of research beyond few
‘frontrunner’ cities as well as outlining some general tendencies in the European
context.
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Du, Plessis Melissa. "A qualitative investigation into the relationship between self-concept and the propensity for role uptake in a small group." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/30160.
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When regarding the history of role theory, one becomes aware of the fact that, although much knowledge is available specifically pertaining to roles in small group settings (e.g. expectations about behaviour, types of roles, flexibility of locus, appropriateness of the role system, dynamic nature of role formation and development as well as typologies dividing roles into categories), not much literature is available specifically pertaining to what the impact of an individual’s self-concept is on his/her propensity to either assume or avoid certain roles in such a setting. Accordingly, this study aimed to explore the above-mentioned aspect of role division in small groups. Research was done by means of a case study research design, with a constructivist/interpretevist meta-theoretical paradigm as research approach. This paradigm holds that there are multiple subjective realities involved when studying human interactions and the consequences thereof. The study was furthermore conducted from a psychodynamic and systems theory perspective. Data was collected from a sample of postgraduate students, who participated in a training group as part of their Industrial and Organisational Psychology master’s degree programme at the University of Pretoria, by means of three different methods, namely video and voice recordings, a document study, as well as semi-structured interviews. Data was furthermore analysed by Atlas.ti, a qualitative data analysis programme, according to the principles of constructivist grounded theory. When regarding current literature on the subject, it is implied by some that an individual will only allow roles to be imposed on him/her if he/she is predisposed to assuming such roles, and if he/she can accordingly integrate the responsibility somehow with his/her self-concept. Accordingly, the results obtained showed some connection between an individual’s self-concept and the role(s) that was assumed by the individual in the small group setting. More specifically, the results showed that an individual is more likely to change roles with ease should the alternate role requirements also be in line with elements of the individual’s self-concept. The results further indicated that it might be difficult for an individual to adapt and change to another role should the roles, which are required in the small group setting, be in conflict with the individual’s self-concept. These findings thus imply that an individual’s self-concept might have an impact on an individual’s propensity to either assume or avoid certain roles (role valency) in a small group setting.Dissertation (MCom)--University of Pretoria, 2011.
Human Resource Management
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Leal, Acácia Gonçalves Ferreira. "Conhecimento de profissionais da saúde sobre conceitos relacionados à ciência do exercício: um estudo transversal." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4892.
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Regular practice of regular exercise has been increasingly seen as an important tool for the prevention and treatment of chronic diseases related to sedentary lifestyle. In addition, regular physical exercise is an important tool for the improvement of physical fitness attributes such as strength, muscle endurance and power, cardiorespiratory endurance and others. Physical exercise effects, acute or chronic are investigated in exercise science. The exercise science is the science of the techniques and methods used in assessing the suitability and fitness of individuals and teams. Additionally, are the disciplines related to exercise science investigating the benefits of exercise. However, these goals are achieved only if the exercise is prescribed and well oriented. For this reason it is very important that the health professional has the right knowledge of the concepts and use of the disciplines related to exercise science. Goal:To assess the knowledge of disciplines related to exercise science in health care professionals. Methods: the evidence of health professionals were analyzed who participated in the qualifying process for entry into the Specialization Course in Exercise Physiology, Federal University of São Paulo conducted between 2004 and 2008. In total, the evidence of 300 physiotherapists were evaluated, 705 physical education teachers and 142 nutritionists. For the purposes of the study, questions were analyzed on maximal oxygen uptake ( O2 máx) (4 questions), assessment of physical fitness (3 questions), physical training (2 questions), bioenergy (1 questions) and exercise in special conditions (1 questions).Results:The results of this study reveal ignorance of health professionals about some concepts related to exercise science (eg.: maximal oxygen consumption).Conclusion: This scenario is worrisome because the benefits of regular exercise are achieved only if it is prescribed and well oriented.The results of this study reinforce the need for continuing education of health professionals in order to minimize the lack of knowledge on subjects related to exercise science and maximixar the service provided by these professionals.However, professionals reviewed here, have a good knowledge in matters related to assessment and physical fitness training.
A prática regular de exercício físico regular tem sido cada vez mais considerada uma ferramenta importante para a prevenção e o tratamento de doenças crônicas relacionadas ao sedentarismo. Adicionalmente, o exercício físico regular é uma ferramenta importante para o aprimoramento dos atributos da aptidão física, tais como, força, resistência e potência musculares, resistência cardiorespiratória e outros. Os efeitos do exercício físico, agudo ou crônico, são investigados pela ciência do exercício. A ciência do exercício é a ciência das técnicas e métodos usados na avaliação da aptidão e condicionamento físico de indivíduos e equipes. Adicionalmente, são as disciplinas relacionadas à ciência do exercício que investigam os benefícios do exercício físico. Entretanto, estes objetivos somente são atingidos se o exercício físico for bem prescrito e orientado. Por este motivo, é muito importante que o profissional da saúde tenha o correto conhecimento dos conceitos relacionadas à ciência do exercício. Objetivo: avaliar o conhecimento relacionado à ciência do exercício em profissionais da saúde. Métodos: Foram analisadas as provas de profissionais da saúde que participaram do processo classificatório para o ingresso no Curso de Especialização em Fisiologia do Exercício da Universidade Federal de São Paulo, realizados entre os anos de 2004 e 2008. No total, foram avaliadas as provas de 142 nutricionistas, 300 fisioterapeutas, 705 educadores físicos. Para os propósitos do estudo, foram analisadas questões sobre consumo máximo de oxigênio ( O2máx) (4 questões), avaliação da aptidão física (3 questões), treinamento físico (2 questões), bioenergética (1 questão) e exercício físico em condições especiais (1 questão). Resultados: Os resultados do presente estudo revelam desconhecimento dos profissionais da saúde sobre alguns conceitos relacionados à ciência do exercício (p.ex.: consumo máximo de oxigênio). Conclusão: Tal cenário é preocupante, pois os benefícios do exercício físico regular somente são atingidos se este for bem prescrito e orientado. Os resultados do presente estudo reforçam a necessidade de educação continuada de profissionais da saúde, a fim de minimizar a falta de conhecimento sobre disciplinas relacionadas à ciência do exercício e maximizar o serviço prestado por esses profissionais. Em contrapartida, os profissionais aqui analisados, apresentam um bom conhecimento nos assuntos relacionados à avaliação e ao treinamento da aptidão física.
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Hijazin, Tahani Jazza'a Mousa Verfasser], Dirk [Akademischer Betreuer] [Selmar, and Peter [Akademischer Betreuer] Winterhalter. "Uptake and modification of coumarins by plants – a coherent phenomenon extending the concept of Horizontal Natural Product Transfer / Tahani Jazza'a Mousa Hijazin ; Dirk Selmar, Peter Winterhalter." Braunschweig : Technische Universität Braunschweig, 2021. http://d-nb.info/1238780113/34.
Full textBooks on the topic "Concepts' uptake"
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Nyquist Potter, Nancy. The Virtue of Defiance and Psychiatric Engagement. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199663866.001.0001.
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The Virtue of Defiance and Psychiatric Engagement argues that defiance sometimes is a virtue even for those with mental illnesses. It also argues that defiance is sometimes mistaken as a sign of mental disorder when it may have other, reasonable explanations. This book offers a nuanced and complex look at defiance, taking seriously issues of mental disorders while also attending to social contexts in which defiant behavior may arise. Arguments are presented for how to understand defiance as different from noncompliance, resistance, and other related concepts, and how defiance is related to living a life with a realistic understanding of a flourishing life and its limits in our everyday world. A framework for differentiating different forms of defiance is offered, and a realistic picture of phronesis—practical reasoning—is presented that makes room for clinicians as well as patients to assess the degree to which defiance is reasonable. The concept of intersectionality as it relates to child development is worked through to highlight some of the challenges clinicians face when interpreting defiant behavior. Particular attention is given to issues of race and gender as factors that need to be considered when evaluating defiant behavior as reasonable, virtuous, bad, or symptomatic. Practical applications for psychiatric engagement are threaded throughout this book through case studies and personal narratives. The virtue of giving uptake is introduced to assist psychiatrists in being responsible and ethical knowers when working with people who are or seem to be defiant.
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Hack, Thomas F., Kinta Beaver, and Penelope Schofield. Audio-recording cancer consultations for patients and their families—putting evidence into practice. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198736134.003.0010.
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This chapter aims to briefly review the empirical literature on the value of consultation audio-recordings for patients and families; conduct a theory-driven examination of the factors that limit practice uptake of this intervention; and provide practical suggestions for how these factors might best be addressed to enhance clinical uptake of consultation audio-recording use. The Promoting Action on Research Implementation in Health Services (PARIHS) Framework is used to examine the impact of scientific evidence, context-specific factors, and facilitation principles, as these pertain to the uptake of consultation audio-recording in practice. Important considerations in efforts to implement a consultation audio-recording service are provided, including leadership, perceived value and benefit, resource costs, technological practicalities, litigation concerns, and staff training and support. Both top-down and bottom-up approaches to implementation are recommended to enhance the likelihood of successful uptake into practice.
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Adamec, Lubomír, and Andrej Pavlovič. Mineral nutrition of terrestrial carnivorous plants. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198779841.003.0017.
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Mineral nutrition is thought to be the key process leading to the evolution of botanical carnivory. This chapter reviews the current understanding of ecophysiological processes associated with mineral nutrition of terrestrial carnivorous plants, with most attention to papers published since 1990 and to integrative studies of Nepenthes. It compares various characteristics of mineral nutrition of terrestrial carnivorous plants under both field and greenhouse conditions and emphasizes processes of the mineral nutrient economy of carnivorous plants: nutrient uptake efficiency from prey carcasses and reutilization of mineral nutrients from senesced shoots. The primary physiological effect of foliar capture of prey is the stimulation of nutrient uptake by roots. The chapter explains the concept of mineral cost of carnivory and highlights open questions associated with mineral nutrition of terrestrial carnivorous plants.
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Sun, Huatong. Global Social Media Design. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190845582.001.0001.
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Social media users fracture into tribes, but social media ecosystems are globally interconnected technically, socially, culturally, and economically. At the crossroads, Huatong Sun, author of Cross-Cultural Technology Design, presents theory, method, and case studies to uncover the global interconnectedness of social media design and reorient universal design standards. Centering on the dynamics between structure and agency, Sun draws on practices theories and transnational fieldwork and articulates a critical design approach. The culturally localized user engagement and empowerment (CLUE2, or CLUE-squared) framework extends from situated activity to social practice and connects macro institutions with micro interactions to redress asymmetrical relations in everyday life. Why were Japanese users not crazed about Facebook? Would Twitter have been more successful than its copycat Weibo in China if not banned? How did mobilities and value propositions play out in the competition of WhatsApp, WeChat, LINE, and KakaoTalk for global growth? Illustrating the cultural entanglement with a relational view of design, Sun provides three provocative accounts of cross-cultural social media design and use. Concepts such as affordance, genre, and uptake are demonstrated as design tools to bind the material with the discursive and leap from the critical to the generative for culturally sustaining design. Sun calls to reshape the crossroads into a design square where differences are nourished as design resources, where diverse discourses interact for innovation, and where alternative design epistemes thrive from the local. This timely book will appeal to researchers, students, and practitioners who design across disciplines, paradigms, and boundaries to bridge differences in this increasingly globalized world.
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Reading 2011 Concept Literacy Reader Grade 2 Week 2 Unit 4 Lets Clean Upthe Park. Savvas Learning Company, 2009.
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Shiffrin, Seana Valentine. Deceptive Advertising and Taking Responsibility for Others. Edited by Anne Barnhill, Mark Budolfson, and Tyler Doggett. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780199372263.013.30.
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This chapter considers how the U.S. law of deceptive advertising embeds within it an extended form of responsibility, making advertisers sometimes responsible for consumers’ mistakes. The chapter justifies this pattern of liability as a division of moral labor that bolsters consumers’ ability to trust the quality of the food supply and the representations made about it. It answers worries about paternalism, arguing that the law is not predicated on distrust of consumers, but facilitates consumer autonomy, permitting consumers to direct their scarce time and energy to projects of their own choosing. The chapter also answers freedom of speech concerns about restricting advertisers’ ability to make factually true representations. It emphasizes that commercial speakers have a special responsibility to ensure accurate uptake by consumers because property law affords commercial producers the ability to exclude consumers and their representatives from verifying speech about speakers’ products for themselves.
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Whelan, Brett, and James Taylor. Precision Agriculture for Grain Production Systems. CSIRO Publishing, 2013. http://dx.doi.org/10.1071/9780643107489.
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Precision Agriculture (PA) is an approach to managing the variability in production agriculture in a more economic and environmentally efficient manner. It has been pioneered as a management tool in the grains industry, and while its development and uptake continues to grow amongst grain farmers worldwide, a broad range of other cropping industries have embraced the concept. This book explains general PA theory, identifies and describes essential tools and techniques, and includes practical examples from the grains industry.
Readers will gain an understanding of the magnitude, spatial scale and seasonality of measurable variability in soil attributes, plant growth and environmental conditions. They will be introduced to the role of sensing systems in measuring crop, soil and environment variability, and discover how this variability may have a significant impact on crop production systems. Precision Agriculture for Grain Production Systems will empower crop and soil science students, agronomy and agricultural engineering students, as well as agronomic advisors and farmers to critically analyse the impact of observed variation in resources on crop production and management decisions.
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Naidu, Ravi, Euan Smith, Gary Owens, Prosun Bhattacharya, and Peter Nadebaum. Managing Arsenic in the Environment. CSIRO Publishing, 2006. http://dx.doi.org/10.1071/9780643093515.
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Arsenic is one of the most toxic and carcinogenic elements in the environment. This book brings together the current knowledge on arsenic contamination worldwide, reviewing the field, highlighting common themes and pointing to key areas needing future research.
Contributions discuss methods for accurate identification and quantification of individual arsenic species in a range of environmental and biological matrices and give an overview of the environmental chemistry of arsenic. Next, chapters deal with the dynamics of arsenic in groundwater and aspects of arsenic in soils and plants, including plant uptake studies, effects on crop quality and yield, and the corresponding food chain and human health issues associated with these exposure pathways. These concerns are coupled with the challenge to develop efficient, cost effective risk management and remediation strategies: recent technological advances are described and assessed, including the use of adsorbants, photo-oxidation, bioremediation and electrokinetic remediation.
The book concludes with eleven detailed regional perspectives of the extent and severity of arsenic contamination from around the world. It will be invaluable for arsenic researchers as well as environmental scientists and environmental chemists, toxicologists, medical scientists, and statutory authorities seeking an in-depth view of the issues surrounding this toxin.
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Thomson, Jennifer. GM Crops and the Global Divide. CSIRO Publishing, 2021. http://dx.doi.org/10.1071/9781486312665.
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Attitudes to GM crops continue to generate tension, even though they have been grown commercially for over 20 years. Negative sentiment towards their development limits their adoption in Western countries, despite there being no evidence of harm to human health. These unfounded concerns about genetically modified crops have also inhibited uptake in many countries throughout Africa and Asia, having a major impact on agricultural productivity and preventing the widespread cultivation of potentially life-saving crops.
GM Crops and the Global Divide traces the historical importance that European attitudes to past colonial influences, aid, trade and educational involvement have had on African leaders and their people. The detrimental impact that these attitudes have on agricultural productivity and food security continues to be of growing importance, especially in light of climate change, drought and the potential rise in sea levels – the effects of which could be mitigated by the cultivation of GM and gene-edited crops.
Following on from her previous books Genes for Africa, GM Crops: The Impact and the Potential and Food for Africa, Jennifer Thomson unravels the reasons behind these negative attitudes towards GM crop production. By addressing the detrimental effects that anti-GM opinions have on nutrition security in developing countries and providing a clear account of the science to counter these attitudes, she hopes to highlight and ultimately bridge this global divide.
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Richardson, Henry. Articulating the Moral Community. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190247744.001.0001.
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As this highly original work explains, morality is not fixed objectively, independently of all human judgment, nor is it something that we “invent.” Rather, working within zones of objective indeterminacy, the moral community—the community of all persons—has the authority to introduce new moral norms. These further specify the preexisting moral norms, making an objective difference to individuals’ moral rights and duties. The moral community, so-called, could not exercise authority unless it had some structure whereby it could act. Unlike political communities, which are centralized, noninclusive, and backed by coercion, the moral community is decentralized and inclusive. Its structure depends upon dyadic duties—ones that one individual owes to another. Such duties, the book argues, empower efforts by individuals to work out intelligently with one another how to respond to morally important concerns. The innovative moral input that these efforts can provide is initially authoritative only over the parties involved. Yet when such innovations gain sufficient uptake and have been reflectively accepted by the moral community, they become new moral norms. This account of the moral community’s moral authority is motivated by, and supports, a type of normative ethical theory, constructive ethical pragmatism (CEP), which rejects the consequentialist claim that rightness is to be defined as a function of goodness and the deontological claim that principles of right are fixed independently of the good. Rather, it holds instead that what we ought to do is fixed by our continuing efforts to specify the right and the good in light of each other.
Book chapters on the topic "Concepts' uptake"
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DeJong, T. M. "Uptake and assimilation of nutrient resources." In Concepts for understanding fruit trees, 18–21. Wallingford: CABI, 2022. http://dx.doi.org/10.1079/9781800620865.0003.
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Abstract Fruit trees require six macronutrients (N, P, K, calcium, Mg and sulfur) and eight micronutrients (Zn, Fe, B, Mn, Cu, chlorine, nickel and molybdenum) that are taken up through the roots. Many of these occur naturally in the soil as cations bound to negatively charged soil particles, while others are dissolved in the liquid surrounding the soil particles in the form of anions. This chapter discusses the uptake and assimilation of nutrient resources in fruit trees. Tabulated data are given on mean annual N, P and K storage (kg/ha) in perennial organs of mature almond trees that received N fertilizer at 309 kg/ha.
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Worms, P., N. Coutou, and K. Biziere. "Selective Antagonism by Serotonin Uptake Inhibitors of H 75/12-lnduced Hyperthermia in Rats." In New Concepts in Depression, 90–95. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-09506-3_7.
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Mitra, Gyanendranath. "Essential Plant Nutrients and Recent Concepts about their Uptake." In Essential Plant Nutrients, 3–36. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-58841-4_1.
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Briley, M., and C. Moret. "Modulation of 5-HT Autoreceptors Probably Contributes to the Antidepressant Action of 5-HT Uptake Blockers." In New Concepts in Depression, 15–24. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-09506-3_2.
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Pawłowski, L. "Effects of the Membrane-active Antidepressant Drugs, Selective 5-HT or NA Uptake Inhibitors, on p-Chloroamphetamine (PCA)-induced Hyperthermia in Heat-adapted Rats." In New Concepts in Depression, 204–10. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-09506-3_17.
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Egarter Vigl, Lukas, Daniel Depellegrin, and Ieva Misiune. "Conceptualizing Human–Nature Interactions – An Overview." In Human-Nature Interactions, 3–11. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-01980-7_1.
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Significance StatementThe threats posed by climate change and global biodiversity loss are increasingly seen as a major problem for the future of nature and humanity. Significant improvements in the understanding of how human and nature interact are thus required to address both challenges comprehensively. Over the past decade, different nature-based approaches, such as Ecosystem-based Adaptation (EbA), Green Infrastructure (GI), and Nature’s Contributions to People (NCP), have enriched the scientific discourse and gained prominence in policy- and decision-making. However, the underlying concepts are vaguely defined, and their systematic uptake is hampered by a lack of clarity over the relationships and overlaps between different nature-based approaches. Here, we discuss recent advances in conceptualizing human–nature interactions with the aim of making these concepts more tangible and applicable for a broader audience.
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Pedersen, Michael, Pietro Irrera, Walter Dastrù, Frank G. Zöllner, Kevin M. Bennett, Scott C. Beeman, G. Larry Bretthorst, Joel R. Garbow, and Dario Livio Longo. "Dynamic Contrast Enhancement (DCE) MRI–Derived Renal Perfusion and Filtration: Basic Concepts." In Methods in Molecular Biology, 205–27. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_12.
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AbstractDynamic contrast-enhanced (DCE) MRI monitors the transit of contrast agents, typically gadolinium chelates, through the intrarenal regions, the renal cortex, the medulla, and the collecting system. In this way, DCE-MRI reveals the renal uptake and excretion of the contrast agent. An optimal DCE-MRI acquisition protocol involves finding a good compromise between whole-kidney coverage (i.e., 3D imaging), spatial and temporal resolution, and contrast resolution. By analyzing the enhancement of the renal tissues as a function of time, one can determine indirect measures of clinically important single-kidney parameters as the renal blood flow, glomerular filtration rate, and intrarenal blood volumes. Gadolinium-containing contrast agents may be nephrotoxic in patients suffering from severe renal dysfunction, but otherwise DCE-MRI is clearly useful for diagnosis of renal functions and for assessing treatment response and posttransplant rejection.Here we introduce the concept of renal DCE-MRI, describe the existing methods, and provide an overview of preclinical DCE-MRI applications to illustrate the utility of this technique to measure renal perfusion and glomerular filtration rate in animal models.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction is complemented by two separate publications describing the experimental procedure and data analysis.
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Jansson, Åsa. "Introduction: Disordered Mood as Historical Problem." In From Melancholia to Depression, 1–33. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54802-5_1.
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Abstract The introduction situates the narrative of this book—the reconceptualisation of melancholia in nineteenth-century psychiatry—firstly in the context of current attempts to ‘resurrect’ melancholia as a psychiatric diagnosis, secondly in relation to the history of melancholia more broadly, and finally in the context of past and present debates about classification in psychiatry. The core argument of the book is briefly outlined: in the nineteenth century, melancholia was reconfigured as a modern biomedical disorder of emotion. Two developments in particular were foundational to this new model of melancholia. The first was the uptake of physiological language and concepts into psychological medicine. The second was the institutionalisation of medical statistics together with a standardisation of asylum recording practices.
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Scaglione, Miriam, Yasuo Ohe, and Colin Johnson. "Tourism Management in Japan and Switzerland: Is Japan Leapfrogging Traditional DMO’s Models? A Research Agenda." In Information and Communication Technologies in Tourism 2021, 389–402. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65785-7_37.
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AbstractSimilarities may be seen in the development of tourism in Japan and Switzerland during the nineteenth and twentieth centuries, especially in terms of the origins and purpose of their respective national tourism offices. In the twenty-first century, however, fundamental differences became evident. During the first decades of the twenty-first century, Switzerland, that had been quick to see the opportunities of e-tourism, was less dynamic in response to the fourth and fifth industrial revolutions, whereas the opposite happened in Japan. Switzerland as with Austria and Germany, adopted a traditional concept of DMO’s that was location-base and limited regionally by administrative boundaries. The Information and Communication Technologies (ICT) development after Web1.0 and the emergence of mobile applications have challenged this concept. A more contemporary view is based more on network travel and visitor flows rather than physical territory. The Japan Central government decided to adopt the western DMO concept as regional tourism policy, but relatively late in 2016.The aim of this innovative research project is to analyze the adoption/implementation of the new concept of DMO’s focusing on Switzerland and Japan. For Switzerland, the main barrier is the scarcity of data given the slower uptake of the technology emanating from the fourth and fifth industrial revolutions. In Japan, the situation may be seen to be inverted, given the country’s proclivity to adopt the advantages from the latest industrial revolution. This may mean that Japan could leapfrog the traditional DMO concept. This research presents the Bass’ analysis of DMO’s websites as a proxy of DMO concepts – traditional or new generation.
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Loeber, Anne, Michael J. Bernstein, and Mika Nieminen. "Implementing Responsible Research and Innovation: From New Public Management to New Public Governance." In Putting Responsible Research and Innovation into Practice, 211–28. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14710-4_11.
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AbstractThe European Commission’s pursuit of “Responsible Research and Innovation” (RRI) and its implementation in the European Research Area serve to investigate how ambitious policy goals can be conveyed into action. Challenging about implementing policy is the need to foster coherence in the interpretation of policy goals while coordinating their elaboration in practice. This chapter identifies the European Commission’s approach to implementing RRI as a case of New Public Management, and contrasts this with efforts at ‘bottom-up’ RRI implementation. Experiments with involving researchers and other stakeholders in designing and executing concrete RRI actions that fit their professional setting are understood as manifestations of a New Public Governance approach to implementing RRI policy. It is found that such deliberation of policy concepts and goals, and their concretization in a context-specific learning-by-doing approach practically enables the uptake of normative policy ambitions in networks of interdependent, non-hierarchically related actors across diverse substantive and administrative contexts.
Conference papers on the topic "Concepts' uptake"
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Ginigaddara, B., S. Perera, Y. Feng, and P. Rahnamayiezekavat. "Offsite construction skills prediction: A conceptual model." In 10th World Construction Symposium. Building Economics and Management Research Unit (BEMRU), University of Moratuwa, 2022. http://dx.doi.org/10.31705/wcs.2022.52.
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Industry 4.0 driven technological advancements have accelerated the uptake of Offsite Construction (OSC), causing the need for re-skilling, up-skilling, and multi-skilling traditional onsite construction skills and competencies. The purpose of this paper is to develop a conceptual model that predicts OSC skills as a response to the OSC demand. The paper is a theoretical presentation of a skill profile prediction model which introduces the key concepts, OSC typology, OSC skill classification and their relationships. Components, panels, pods, modules, and complete buildings represent the OSC typology. Managers, professionals, technicians, and trade workers, clerical and administration workers, machine operators and drivers, and labourers constitute the OSC skill classification. The conceptual model takes the OSC project parameters: gross floor area, OSC value percentage and skill quantities as input and provides predicted skill variations as the output. The skills are quantified in “manhours/m2” under six skill categories, for five distinct OSC types. As such, the research presents a comprehensive conceptual model for the development of an OSC skills predictor to capture the skill variations and demand in a construction market moving towards rapid industrialisation. The research contributes to the existing body of knowledge by identifying the key concepts, parameters, and mutual relationships of those parameters that are needed to develop a realistic prediction of future trends of OSC skills.
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Capello, Maria Angela, Denise Cox, and Linda Battalora Battalora. "Social Media and the Oil & Gas Sector: Challenges and Opportunities." In SPE Annual Technical Conference and Exhibition. SPE, 2022. http://dx.doi.org/10.2118/210172-ms.
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Abstract There are currently 4.62 billion users of social media worldwide1. This means that more than half of the population of the world uses social media (58.4%)2. The Oil and Gas sector cannot escape this reality, which is so valuable for communications and positioning strategies. One of the top-valued goals of modern organizations in all sectors is to have a positive presence on social media. For the oil and gas sector, this is particularly needed, as energy transition concepts are not necessarily well understood nor ingrained in society at large, making it difficult to revert any negative public opinion matrix about the sector. The COVID-19 pandemic forced many traditional organizations in the oil and gas sector to embrace social media, increasing their active presence on the main professional online platforms, gaining more engagement with their own employees and society like never before. This paper compares the social media presence of prominent organizations related to oil and gas in 2022, analyzing trends and highlighting opportunities and challenges. A comparison of key elements considered diagnostic in improving the recognition and reputation of oil and gas organizations are addressed in more detail, in particular sustainability and DE&I (gender representation, generally addressed as Diversty, Equity and Inclusion). Conclusions are related to cultural frameworks, selected language for postings, geo-political affinities, and the profile of the companies analyzed. Framing the current trends analyzed resulted in the identification of organizations that are more successful in the utilization of these key channels that are important to general audiences and especially to younger generations. Some unexpected findings shaped our conclusions that strategies needed for step-changes in political or cultural settings benefit greatly from the use of social media and have proven to be effective in furthering women's empowerment and for the uptake of sustainability at the corporate level.
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Pamungkasari, Eti Poncorini, and Bhisma Murti. "Factors Affecting the Use of Antenatal Care in Semarang, Central Java: Application of Health Belief Model." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.03.117.
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ABSTRACT Background: In the field of health-care education, theories and models help us to explain and predict behaviors to conduct effective health-care educational programs for changing behaviors. The Health Belief Model (HBM) contains several primary concepts by which individuals evaluate themselves to take action to change their behaviors, including antenatal care uptake in pregnant women. This study aimed to examine factors affecting the use of antenatal care. Subjects and Method: A cross sectional study was carried out in Semarang, Central Java, from June to August 2020. A sample of 250 pregnant women was selected by simple random sampling. The dependent variable was antenatal care. The independent variables were attitude, knowledge, information, self-efficacy, perceived seriousness, perceived susceptibility, perceived barrier, perceived benefit, cues to action, husband support, and facilities. The data were collected by questionnaire and analyzed by a multiple logistic regression. Results: Complete antenatal care increased with strong support (OR= 38.97; 95% CI= 3.19 to 476.53; p= 0.004), high knowledge (OR= 16.44; 95% CI= 2.54 to 106.60; p= 0.003), positive attitude (OR= 29.88; 95% CI= 2.88 to 309.92; p= 0.004), high information toward antenatal care (OR= 31.42; 95% CI= 4.07 to 242.41; p= 0.001), strong self-efficacy (OR= 7.85; 95% CI= 1.50 40.99; p= 0.015), strong cues to action (OR= 11.97; 95% CI= 2.01 to 71.36; p= 0.006), high perceived seriousness (OR= 32.99; 95% CI= 3.93 to 276.98; p= 0.001), high perceived susceptibility (OR= 24.29; 95% CI= 2.50 to 235.78; p= 0.006), high perceived benefit (OR= 30.43; 95% CI= 2.99 to 308.80; p= 0.004), high perceived barrier (OR= 0.07; 95% CI= 0.01 to 0.57; p= 0.013) and complete facilities (OR= 63.52; 95% CI= 3.62 to 1115.08; p= 0.005). Conclusion: Complete antenatal care increases with strong support, high knowledge, positive attitude, high information toward antenatal care, strong self-efficacy, strong cues to action, high perceived seriousness, high perceived susceptibility, high perceived benefit, high perceived barrier and complete facilities. Keywords: antenatal care, health facility, Health Belief Model Correspondence: Widyawati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: widyawatichin1412@gmail.com. Mobile: +6285742919076. DOI: https://doi.org/10.26911/the7thicph.03.117
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Albro, Michael B., Roland Li, Rajan E. Banerjee, Clark T. Hung, and Gerard A. Ateshian. "Direct Validation of Active Solute Transport Induced by Dynamic Loading of Porous Hydrated Media." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206028.
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Transport pathways play a key role in maintaining cellular metabolic activity in biological tissues. Efforts to maintain or enhance the transport of nutrients may prove beneficial to the maintenance of native or development of engineered tissue. Various studies have investigated the potential of dynamic mechanical loading to increase the uptake and desorption rates of solutes in articular cartilage [1, 2]. Recently, a novel concept has been theoretically suggested that such dynamic loading of porous deformable media may additionally yield higher steady state concentrations of solutes, beyond those achieved by passive diffusion [3]. The first experimental evidence that dynamic loading can significantly enhance solute uptake over passive diffusion was recently reported for a model system of dextran in agarose hydrogels [4]. The results of this experimental study [4] were interpreted in the context of the earlier theoretical predictions [3], though a direct validation of theory with experiments has not yet been attempted. Therefore, the current study focuses on directly validating the theoretical framework by independently measuring the mechanical and transport properties of agarose hydrogels and dextran solutions experimentally, and substituting these values into the theory to evaluate the predicted solute uptake. These predictions are then compared to the previously reported experimental measurements of uptake of dextran in agarose under dynamic loading [4], for several gel concentrations and solute molecular weights.
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Buczko, W., M. Pietraszek, E. Chabielska, and B. Malinowska. "THE INFLUENCE OF SOME HYPOTENSIVE DRUGS ON THE SEROTONERGIC MECHANISMS IN RATS PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643440.
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Serotonin (5HT) is a vasoactive amine that has been reported to be involved in a number of forms of circulatory failure. The 5HT content and metabolism in platelets is changed in hypertension and in peripheral arteriolar diseases. The present study concerns the effect of verapamil (VER), propranolol (PRO) and cap-topril (CAP) - drugs having different hypotensive mechanisms of action, on serotonergic mechanisms in rat blood platelets. In vitro, VER produced noncompetitive inhibition of 14C-5HT uptake (IC50=8.2μM), PRO inhibited the uptake in a competitive fashion (Km =0.9μM), whereas CAP was ineffective. Only PRO released (24%) radioactive 5HT from incubated platelets. Inhibition of amine uptake was also obtained when plateletswere prepared from-irats pretreated with VER (10 mg.kg−1 ), PRO (5 mg.kg−1) or CAP (10 mg.kg−1 ). Moreover, the concentration of endogenous 5HT in blood platelets was reduced after VER and PRO administration. Platelets aggregation induced by ADP was inhibited by VER and CAP. They also diminished the potentiating effect of 5HT on ADP-induced platelet aggregation. It can be concluded that these effects may be a secondary mechanism of action in vivo. Thus “serotonergic component” of studied drugs should be taken under consideration at least in therapy of hypertension.Supported by CPBR, no 11.6
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Ramatullayev, Samat, Muzahidin Muhamed Salim, Muhammad Ibrahim, Hussein Mustapha, Obeida El Jundi, Nour El Droubi, and Alaa Maarouf. "Intelligent Waterflood Optimization Advisory System – A Step Change Towards Digital Transformation." In Abu Dhabi International Petroleum Exhibition & Conference. SPE, 2021. http://dx.doi.org/10.2118/207946-ms.
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Abstract In this paper, we discuss the development of an end-to-end waterflood optimization solution that provides monitoring and surveillance dashboards with artificial intelligence (AI) and machine learning (ML) components to generate and assess insights into waterflood operational efficiency in an automated manner. The solution allows for fast screening of waterflood performance at diverse levels (reservoir, sector, pattern, well) enabling prompt identification of opportunities for immediate uptake into an opportunity management process and for evaluation in AI-driven production forecast solution and/or a reservoir simulator. The process starts with the integration of a wide range of production and reservoir engineering data types from multiple sources. Following this, a series of monitoring and surveillance dashboards of key units and elements of the entire waterflood operations are created. The workflows in these dashboards are framed with key waterflood reservoir and production engineering concepts in mind. The optimization opportunity insights are then extracted using automated traditional and AI/ML algorithms. The identified opportunities are consolidated in an optimization action list. This list is passed to an AI-driven production forecast solution and/or a reservoir simulator to assess the impact of each scenario. The system is designed to improve the business-time decision-making cycle, resulting in increased operational performance and lower waterflood operating costs by consolidating end-to-end optimization workflows in one platform. It incorporates both surface and subsurface aspects of the waterflood and provides a comprehensive understanding of waterflood operations from top-down field, reservoir, sector, pattern and well levels. Its AI/ML components facilitate understanding of producer-injector relationships, injector dynamic performance, underperformance of patterns in the sector as well as evaluating the impact of different optimization scenarios on incremental oil production. The data-driven production forecast component consists of several ML models and is tailored to assess their impact on oil production of different scenarios such as changes in voidage replacement ratio (VRR) in reservoir, sector, pattern and well levels. Opportunities are also converted into reservoir simulator compatible format in an automated manner to assess the impact of different scenarios using more rigorous numerical methods. The scenarios that yield the highest impact are passed to the field operations team for execution. The solution is expected to serve as a benchmark, upon successful implementation, for optimizing injection schemas in any field or reservoir. The novelty of the system lies in automating the insights generation process, in addition to integrating with an AI/ML production forecasting solution and/or a reservoir simulator to assess different optimization scenarios. It is an end-to-end solution for waterflood optimization because of the integration of various components that allow for the identification and assessment of opportunities all in one environment.
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Sessions, John W., Brad W. Hanks, Tyler E. Lewis, Brian D. Jensen, Dallin L. Lindstrom, and Sandra H. Burnett. "Saline Solution Effects on Propidium Iodide Uptake in Nanoinjected HeLa Cells." In ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-35431.
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Being able to deliver molecular loads to the intracellular space of mammalian cells is a key initial step of genetic engineering. In the following work, experimentation with nanoinjection, a non-viral molecular load delivery technique, was examined in regards to transmembrane delivery of propidium iodide (PI), a dye that cannot penetrate the cell membrane and fluoresces when bound to genetic material. Investigation includes two environmental factors: peak pulse amplitude (1.5 to 3, 5, 7, or 9 V) and saline type (HBSS, PBS with potassium, and PBS without potassium). Results indicate that PBS with potassium has significantly higher PI uptake efficiency than the other two saline solutions for pulsed voltages of 3V, 5V, and 7V (with the peak value being 3.352 times greater than the positive control). Also, cell viability analysis indicates that there is a measureable reduction in cell viability for voltage protocol samples in comparison to non-voltage protocol samples. Cell viabilities range from 74.5% to 89.4% for voltage protocol samples. Findings suggest that a possible combination of physical/electrical variables work in concert with biological mechanisms to contribute to overall cell survival and PI uptake efficiency in nanoinjection.
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Holzemer-Zerhusen, Philipp, Stefan Brendelberger, Martin Roeb, and Christian Sattler. "Oxygen Crossover in Solid-Solid Heat Exchangers for Solar Water and Carbon Dioxide Splitting: A Thermodynamic Analysis." In ASME 2020 14th International Conference on Energy Sustainability. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/es2020-1608.
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Abstract In solar thermochemical redox cycles for H2O/CO2-splitting, a large portion of the overall energy demand of the system is associated with heating the redox material from the oxidation temperature to the reduction temperature. Hence, an important measure to improve the efficiency is recuperation of sensible heat stored in the redox material. A solid-solid heat exchanger can be subject to undesirable oxygen crossover, which decreases the oxygen uptake capacity of the redox material and consequently the system efficiency. We investigate the extent of this crossover in ceria based cycles, to identify, under which conditions a heat exchanger that allows oxygen crossover can improve the system efficiency. In a thermodynamic analysis we calculate the amount of transferred oxygen as a function of the heat exchanger efficiency and show the system efficiency of such a concept. A second law analysis is applied to the model to check the feasibility of calculated points of operation. For the investigated parameter set the heat exchanger design improves the system efficiency by a factor of up to 2.1.
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Valente, Alexander Ashcroft, and David Rafael Contreras Perez. "Agile Project Management and its Application to Delivering an Integrated Subsurface Model of a Giant Middle Eastern Carbonate Reservoir." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/210827-ms.
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Abstract & Introduction Agile Project Management has received a significant amount of attention in the oil and gas industry over the past five years. Companies have increasingly focused on digitalisation in an attempt to generate additional value from their existing business, and to keep up in a fast changing global marketplace. The uptake of an Agile Approach in the industry has however, been markedly slower than in other industries. Management consultants promoting an agile approach have often presented case studies with limited relevance to oil and gas projects, which has led to scepticism within the workforce. An Abu Dhabi offshore company successfully applied techniques adapted from Agile Project Management during a major reservoir modelling project of a giant oil field. Elements of the agile approach, such as the concept of the Minimum Viable Product, were found to be key enablers in the development of more efficient reservoir modelling workflows. Furthermore, these techniques were effective in overcoming challenges related to remote working, resource constraints, and contradictory field data. This paper introduces the Agile Project Management approach and shares experience of how it can be applied effectively to subsurface modelling projects.
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Salverson, Lynsey A. M., Nader Saniei, Mel Mendelson, and Michelle Lum. "An Engineering Approach Investigating the Uptake and Phytotoxicity of One Type of Engineered Nanoparticle (CdSe/ZnS Quantum Dots) by Solanum Lycopersicum." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14032.
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The novel and extraordinary physiochemical properties of engineered nanoparticles (ENPs) is certain, yet, at the same time, their unique characteristics raise growing concerns regarding potentially adverse effects on biological and ecological systems. It is becoming increasingly evident, that before the full potential of nanotechnology can be realized, standardized characterization of ENPs behavior, fate, and their effects in the ecosystem are essential, to ensure the safe manufacturing and use of ENP products. Otherwise, the promise of such extraordinary advancements may find itself limited to applications such as electronics, and sporting equipments, industries in which it currently resides. The current toxicity profile of engineered nanomaterials is not only preliminary, but highly variable amongst researchers. Emphasizing the great need to develop a highly organized, efficient, and precise approach to assess the hazardous potential ENPs may pose, and address the safety concerns surrounding and limiting nanotechnology. In response to such concerns, the present study took an engineering approach, in an otherwise traditionally viewed discipline, to assess the potential impact of engineered nanoparticles on tomato (Solanum lycopersicum) seedlings, by implementing a full factorial design of experiment (FDOE) in an effort to identify what factors, and their interactions, have a significant (p ≤ 0.05) effect on root and shoot elongation, and if any observed effects are a result of particle uptake, evaluated via fluorescence microscopy imaging. Therefore, the goal of our study was to design and implement an efficient, effective, and precise method to assess the effect of one type of ENP, water-soluble CdSe/ZnS quantum dots, using Solanum lycopersicum as our model organism, one of 10 species recommended by the Unites States Environmental Protection Agency (US EPA) for use in phytotoxicity studies, via a methodology we believe novel to nanotechnology. By implementing factorial experimental design methodologies, not only are we efficiently identifying the factors that affect phytotoxicity, we are providing, for the first time to our knowledge, the first scientific data to report the significant interaction effects between the factors responsible for ENP toxicity. Water soluble (MUA) CdSe/ZnS quantum dots used in our study had a negative influence on root and shoot lengths of tomato seeds exposed for 3 and 6 days. The observed influence depended on (MUA) CdSe/ZnS concentration and QD exposure time. The importance of the factor effects were examined via analysis of variance (ANOVA), t-tests, confidence intervals, and normal plot statistical analyses. The findings concluded that factors B, C, and the BC-interaction (CdSe/ZnS: Exposure time, concentration, and exposure time–concentration interaction) significantly (p ≤ 0.05) affected root and shoot lengths of tomato seedlings. Thus, factors A, AB, AC, and ABC (CdSe/ZnS QD: Size, size–concentration, size-exposure time, and size-concentration-exposure time interactions) were not found to have a significant effect on root and shoot lengths of tomato seedlings, and ultimately eliminated from our model. After analyzing the interaction plots, it became evident that low percentages of root reduction are obtained at low concentration levels for short lengths of time; thus, to obtain the least amount of phytotoxic effects one would set factors B (concentration) and C (exposure time) to their low levels, 125 mg/L for 3 days, respectively. Alternatively, high percentages of root reduction are obtained at high concentration levels for long lengths of time; thus, to obtain the greatest phytotoxic effect one would set factors B and C to their high levels, 1000 mg/L for 6 days, respectively. This indicates that as exposure time increases, root reduction increases; thus, phytotoxicity increases. Since our study attempted to realize which factors minimize phytotoxicity effects of one type of ENP, these findings suggest that to minimize phytotoxicity effects (i.e. maximize root length or minimize percent of root reduction) of (MUA) CdSe/ZnS QDs on tomato seeds, set factors B and C (QD concentration and exposure time) to their low levels; that is, expose tomato seeds to 125 mg/L of QD solution for a maximum of 3 days. These settings will yield the least amount of root reduction (5.15%) and; thus, phytotoxicity effects will be minimized. With regard to tomato roots ability to uptake MUA QDs, our results contribute to the literature by reporting uptake possible. Although we did see particles inside the root, it was sporadic and difficult to quantify. As to whether it was intracellular (within the cell) or intercellular (in the spaces between the cells, i.e., outside the cells) we could not conclude with certainty, although we suspect the QDs were intercellular. Thus, we highly recommend future experiments involving cross sections and more in-depth microscopy imaging. Additionally, although the results of our experiment failed to support that particle size (t = 2.13; d.f. = 1; p = 0.065) or the particle size-exposure time interaction (t = 2.17; d.f. = 1; p = 0.062) had a significant effect on root and shoot lengths of tomato seedlings, due to the small p-value associated with both test statistics, it is our belief that particle size and the particle size-exposure time interaction may, in fact, be a real effect; thus, further investigation is recommended.
Reports on the topic "Concepts' uptake"
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Presseau, Justin, Laura Desveaux, Upton Allen, Trevor Arnason, Judy L. Buchan, Kimberly M. Corace, Vinita Dubey, et al. Behavioural Science Principles for Supporting COVID-19 Vaccine Confidence and Uptake Among Ontario Health Care Workers. Ontario COVID-19 Science Advisory Table, March 2021. http://dx.doi.org/10.47326/ocsat.2021.02.12.1.0.
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Health Care Workers (HCWs) are the backbone of Ontario’s COVID-19 pandemic response and are a key vaccination priority group. About 80% of Ontario HCWs intend to receive COVID-19 vaccine.1 Challenges include the logistics of delivering the vaccine to this mobile and diverse group and improving vaccine confidence in the remaining 20%. These challenges can be overcome by allaying safety concerns and highlighting personal benefits; tailoring messages to factors associated with lower intention (e.g. age, gender, ethnicity and work setting); employing trusted leaders to set the tone and peers to build social norms; and leveraging public health organizations and health institutions as existing channels of influence.
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Schmidt-Sane, Megan, Elizabeth Benninger, Tabitha Hrynick, and Santiago Ripoll. Youth COVID-19 Vaccine Engagement in Cleveland, Ohio, United States. Institute of Development Studies, June 2022. http://dx.doi.org/10.19088/ids.2022.040.
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Despite overall progress in COVID-19 vaccination rates in Cleveland, vaccine inequity persists as young people from minority communities are often less likely to be vaccinated. COVID-19 vaccine hesitancy is not just an issue of misinformation or lack of information. Vaccine hesitancy among young people is reflective of wider issues such as mistrust in the state or the medical establishment and negative experiences during the pandemic. This report is based on case study research conducted among minority youth (ages 12-18) in Cleveland, Ohio. While public discourse may label young people as “vaccine hesitant,” we found that there were hesitation differences based on social location and place. We found the greatest vaccine hesitancy among older youth (15+ years old), particularly those from minoritized communities. Unvaccinated youth were also more likely to be from families and friend groups that were unvaccinated. While some expressed distrust of the vaccines, others reported that COVID-19 prevention was not a priority in their lives. Instead, concerns over food security, livelihood, and education take precedence. Minority youth were more likely to report negative experiences with authorities, including teachers at their schools and police in their communities. Our findings demonstrate that COVID-19 vaccine hesitancy is embedded in a context that drives relationships of mistrust between minority communities and authorities, with implications for COVID-19 vaccine uptake. Young people’s attitudes toward vaccines are further patterned by experiences within their community, school, family, and friend groups.
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Schmidt-Sane, Megan, Tabitha Hrynick, Southall Community Alliance SCA, Charlie Forgacz-Cooper, and Steve Curtis. Youth COVID-19 Vaccine Engagement in Ealing, London, United Kingdom. Institute of Development Studies, June 2022. http://dx.doi.org/10.19088/ids.2022.039.
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Despite progress in COVID-19 vaccination rates overall in Ealing, vaccine inequity persists as young people from minority communities are often less likely to be vaccinated. COVID-19 ‘vaccine hesitancy’ is not just an issue of misinformation or lack of information. ‘Vaccine hesitancy’ among young people is reflective of wider issues such as mistrust in the state or the medical establishment and negative experiences during the pandemic. This report is based on case study research conducted among minority youth (from ages 12-19) in the London borough of Ealing. While public discourse may label young people as “vaccine hesitant,” we found that there were differences based on social location and place. We found the greatest vaccine refusal among older youth (15+ years old), which in the context of this study were from minoritised communities who have experienced deprivation across the life course. Unvaccinated youth were also more likely to be from families and friend groups that were unvaccinated. While some expressed distrust of the vaccines, others reported that COVID-19 prevention was not a priority in their lives, but instead concerns over food security, livelihood, and education take precedence. Minoritised youth were more likely to report negative experiences with authorities, including teachers at their schools and police in their communities. Our findings demonstrate that COVID-19 vaccine hesitancy is embedded in a context that drives relationships of mistrust between minority communities and authorities, with implications for COVID-19 vaccine uptake. Young people’s attitudes toward vaccines are further patterned by experiences within their community, school, family, and friend groups.
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Butler, Nadia, and Soha Karam. Evidence Review: COVID-19 Vaccine Acceptance by Key Influencers in the MENA Region - Teachers and Healthworkers. Institute of Development Studies (IDS), November 2021. http://dx.doi.org/10.19088/sshap.2021.039.
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As COVID-19 vaccines have been deployed and scaled, concerns about vaccine acceptance have emerged. Effective management of the virus requires that communities everywhere buy into the public health measures designed to protect them, including vaccines. Low acceptance presents a serious challenge for achieving sufficient coverage to reduce circulation of the virus and the risk of new variants emerging. Surveys conducted early in the pandemic showed that the Middle East region had one of the lowest COVID-19 vaccine acceptance rates globally. The low acceptance is driven by specific factors in the region and its different countries and populations; these factors need to be taken into account when formulating policy, programmes and interventions. This review synthesises evidence on vaccine acceptance among two key groups in the Middle East and North Africa (MENA) region: teachers and health workers. It draws from academic studies most of which were cross-sectional studies, largely conducted between February 2020 and June 2021, and grey literature reports, including social listening reports. This review is intended to inform strategies for risk communications and community engagement (RCCE) relating to COVID-19 vaccine uptake, with the aim of boosting confidence in and acceptance of the vaccines among these groups across the region. It is part of the Social Science in Humanitarian Action Platform (SSHAP) series on social science considerations relating to COVID-19 vaccines and was developed for SSHAP by Anthrologica (Nadia Butler and Soha Karam) at the request of the UNICEF MENA Regional Office. It was reviewed by Rose Aynsley (WHO) Amaya Gillespie (UNICEF) and Olivia Tulloch (Anthrologica). The evidence review is the responsibility of SSHAP.
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Schmidt-Sane, Megan, Tabitha Hrynick, Elizabeth Benninger, Janet McGrath, and Santiago Ripoll. The COVID-19 YPAR Project: Youth Participatory Action Research (YPAR) to Explore the Context of Ethnic Minority Youth Responses to COVID-19 Vaccines in the United States and United Kingdom. Institute of Development Studies, October 2022. http://dx.doi.org/10.19088/ids.2022.072.
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Despite progress in COVID-19 vaccination rates overall in the US and UK, vaccine inequity persists as young people from minoritised and/or deprived communities are often less likely to be vaccinated. COVID-19 ‘vaccine hesitancy’ is not just an issue of misinformation or lack of information. ‘Vaccine hesitancy’ among young people is reflective of wider issues such as mistrust in the state or the medical establishment and negative experiences during the pandemic. This report is based on case study research conducted among young people (ages 12-18) in Cleveland, Ohio, US and the London borough of Ealing, UK. Whilst public discourse may label young people as ‘vaccine hesitant,’ we found that there were differences based on social location and place and this labelling may portray young people as ‘ignorant.’ We found the greatest vaccine hesitancy among older youth (15+ years old), particularly those from minoritised and deprived communities. Unvaccinated youth were also more likely to be from families and friend groups that were unvaccinated. While some expressed distrust of the vaccines, others reported that COVID-19 prevention was not a priority in their lives, but instead concerns over food security, livelihood, and education take precedence. Minoritised youth were more likely to report negative experiences with authorities, including teachers at their schools and police in their communities. Our findings demonstrate that COVID-19 vaccine hesitancy is embedded in a context that drives relationships of mistrust between minoritised and deprived communities and the state, with implications for COVID-19 vaccine uptake. Young people’s attitudes toward vaccines are further patterned by experiences within their community, school, family, and friend groups.
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Coulson, Saskia, Melanie Woods, Drew Hemment, and Michelle Scott. Report and Assessment of Impact and Policy Outcomes Using Community Level Indicators: H2020 Making Sense Report. University of Dundee, 2017. http://dx.doi.org/10.20933/100001192.
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Making Sense is a European Commission H2020 funded project which aims at supporting participatory sensing initiatives that address environmental challenges in areas such as noise and air pollution. The development of Making Sense was informed by previous research on a crowdfunded open source platform for environmental sensing, SmartCitizen.me, developed at the Fab Lab Barcelona. Insights from this research identified several deterrents for a wider uptake of participatory sensing initiatives due to social and technical matters. For example, the participants struggled with the lack of social interactions, a lack of consensus and shared purpose amongst the group, and a limited understanding of the relevance the data had in their daily lives (Balestrini et al., 2014; Balestrini et al., 2015). As such, Making Sense seeks to explore if open source hardware, open source software and and open design can be used to enhance data literacy and maker practices in participatory sensing. Further to this, Making Sense tests methodologies aimed at empowering individuals and communities through developing a greater understanding of their environments and by supporting a culture of grassroot initiatives for action and change. To do this, Making Sense identified a need to underpin sensing with community building activities and develop strategies to inform and enable those participating in data collection with appropriate tools and skills. As Fetterman, Kaftarian and Wanderman (1996) state, citizens are empowered when they understand evaluation and connect it in a way that it has relevance to their lives. Therefore, this report examines the role that these activities have in participatory sensing. Specifically, we discuss the opportunities and challenges in using the concept of Community Level Indicators (CLIs), which are measurable and objective sources of information gathered to complement sensor data. We describe how CLIs are used to develop a more indepth understanding of the environmental problem at hand, and to record, monitor and evaluate the progress of change during initiatives. We propose that CLIs provide one way to move participatory sensing beyond a primarily technological practice and towards a social and environmental practice. This is achieved through an increased focus in the participants’ interests and concerns, and with an emphasis on collective problem solving and action. We position our claims against the following four challenge areas in participatory sensing: 1) generating and communicating information and understanding (c.f. Loreto, 2017), 2) analysing and finding relevance in data (c.f. Becker et al., 2013), 3) building community around participatory sensing (c.f. Fraser et al., 2005), and 4) achieving or monitoring change and impact (c.f. Cheadle et al., 2000). We discuss how the use of CLIs can tend to these challenges. Furthermore, we report and assess six ways in which CLIs can address these challenges and thereby support participatory sensing initiatives: i. Accountability ii. Community assessment iii. Short-term evaluation iv. Long-term evaluation v. Policy change vi. Capability The report then returns to the challenge areas and reflects on the learnings and recommendations that are gleaned from three Making Sense case studies. Afterwhich, there is an exposition of approaches and tools developed by Making Sense for the purposes of advancing participatory sensing in this way. Lastly, the authors speak to some of the policy outcomes that have been realised as a result of this research.
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Führ, Martin, Julian Schenten, and Silke Kleihauer. Integrating "Green Chemistry" into the Regulatory Framework of European Chemicals Policy. Sonderforschungsgruppe Institutionenanalyse, July 2019. http://dx.doi.org/10.46850/sofia.9783941627727.
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20 years ago a concept of “Green Chemistry” was formulated by Paul Anastas and John Warner, aiming at an ambitious agenda to “green” chemical products and processes. Today the concept, laid down in a set of 12 principles, has found support in various arenas. This diffusion was supported by enhancements of the legislative framework; not only in the European Union. Nevertheless industry actors – whilst generally supporting the idea – still see “cost and perception remain barriers to green chemistry uptake”. Thus, the questions arise how additional incentives as well as measures to address the barriers and impediments can be provided. An analysis addressing these questions has to take into account the institutional context for the relevant actors involved in the issue. And it has to reflect the problem perception of the different stakeholders. The supply chain into which the chemicals are distributed are of pivotal importance since they create the demand pull for chemicals designed in accordance with the “Green Chemistry Principles”. Consequently, the scope of this study includes all stages in a chemical’s life-cycle, including the process of designing and producing the final products to which chemical substances contribute. For each stage the most relevant legislative acts, together establishing the regulatory framework of the “chemicals policy” in the EU are analysed. In a nutshell the main elements of the study can be summarized as follows: Green Chemistry (GC) is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Besides, reaction efficiency, including energy efficiency, and the use of renewable resources are other motives of Green Chemistry. Putting the GC concept in a broader market context, however, it can only prevail if in the perception of the relevant actors it is linked to tangible business cases. Therefore, the study analyses the product context in which chemistry is to be applied, as well as the substance’s entire life-cycle – in other words, the six stages in product innovation processes): 1. Substance design, 2. Production process, 3. Interaction in the supply chain, 4. Product design, 5. Use phase and 6. After use phase of the product (towards a “circular economy”). The report presents an overview to what extent the existing framework, i.e. legislation and the wider institutional context along the six stages, is setting incentives for actors to adequately address problematic substances and their potential impacts, including the learning processes intended to invoke creativity of various actors to solve challenges posed by these substances. In this respect, measured against the GC and Learning Process assessment criteria, the study identified shortcomings (“delta”) at each stage of product innovation. Some criteria are covered by the regulatory framework and to a relevant extent implemented by the actors. With respect to those criteria, there is thus no priority need for further action. Other criteria are only to a certain degree covered by the regulatory framework, due to various and often interlinked reasons. For those criteria, entry points for options to strengthen or further nuance coverage of the respective principle already exist. Most relevant are the deltas with regard to those instruments that influence the design phase; both for the chemical substance as such and for the end-product containing the substance. Due to the multi-tier supply chains, provisions fostering information, communication and cooperation of the various actors are crucial to underpin the learning processes towards the GCP. The policy options aim to tackle these shortcomings in the context of the respective stage in order to support those actors who are willing to change their attitude and their business decisions towards GC. The findings are in general coherence with the strategies to foster GC identified by the Green Chemistry & Commerce Council.
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Balk, Ethan M., Kristin J. Konnyu, Wangnan Cao, Monika Reddy Bhuma, Valery A. Danilack, Gaelen P. Adam, Kristen A. Matteson, and Alex Friedman Peahl. Schedule of Visits and Televisits for Routine Antenatal Care: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), June 2022. http://dx.doi.org/10.23970/ahrqepccer257.
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Background. The American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine plan a new evidence-based joint consensus statement to address the preferred visit schedule and the use of televisits for routine antenatal care. This systematic review will support the consensus statement. Methods. We searched PubMed®, Cochrane databases, Embase®, CINAHL®, ClinicalTrials.gov, PsycINFO®, and SocINDEX from inception through February 12, 2022. We included comparative studies from high-income countries that evaluated the frequency of scheduled routine antenatal visits or the inclusion of routine televisits, and qualitative studies addressing these two topics. We evaluated strength of evidence for 15 outcomes prioritized by stakeholders. Results. Ten studies evaluated scheduled number of routine visits and seven studies evaluated televisits. Nine qualitative studies also addressed these topics. Studies evaluated a wide range of reduced and traditional visit schedules and approaches to incorporating televisits. In comparisons of fewer to standard number of scheduled antenatal visits, moderate strength evidence did not find differences for gestational age at birth (4 studies), being small for gestational age (3 studies), Apgar score (5 studies), or neonatal intensive care unit (NICU) admissions (5 studies). Low strength evidence did not find differences in maternal anxiety (3 studies), preterm births (3 studies), and low birth weight (4 studies). Qualitative studies suggest that providers believe fewer routine visits may be more convenient for patients and may free up clinic time to provide additional care for patients with high-risk pregnancies, but both patients and providers had concerns about potential lesser care with fewer visits. In comparisons of hybrid (televisits and in-person) versus in-person only visits, low strength evidence did not find differences in preterm births (4 studies) or NICU admissions (3 studies), but did suggest greater satisfaction with hybrid visits (2 studies). Qualitative studies suggested patients and providers were open to reduced schedules and televisits for routine antenatal care, but importantly, patients and providers had concerns about quality of care, and providers and clinic leadership had suggestions on how to best implement practice changes. Conclusion. The evidence base is relatively sparse, with insufficient evidence for numerous prioritized outcomes. Studies were heterogeneous in the care models employed. Where there was sufficient evidence to make conclusions, studies did not find significant differences in harms to mother or baby between alternative models, but evidence suggested greater satisfaction with care with hybrid visits. Qualitative evidence suggests diverse barriers and facilitators to uptake of reduced visit schedules or televisits for routine antenatal care. Given the shortcomings of the evidence base, considerations other than proof of differences in outcomes may need to be considered regarding implications for clinical practice. New studies are needed to evaluate prioritized outcomes and potential differential effects among different populations or settings.
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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, June 2013. http://dx.doi.org/10.32747/2013.7699847.bard.
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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL target genes and bioinformatic analysis of data to eulcidate gene-network topology. Objective-3 (Israel-TAU): Regulation of GTLmediated transcription by Ca²⁺/calmodulin: mechanism and biological significance. Objective-4 (Israel-BGU): Metabolic networks and carbon partitioning in response to drought. Additional direction: In the course of the project we added another direction, which was reported in the 2nd annual report, to elucidate genes controlling drought avoidance. The TAU team has isolated a few unhydrotropic (hyd) mutants and are in the process of mapping these mutations (of hyd13 and hyd15; see last year's report for a description of these mutants under salt stress) in the Arabidopsis genome by map-based cloning and deep sequencing. For this purpose, each hyd mutant was crossed with a wild type plant of the Landsberg ecotype, and at the F2 stage, 500-700 seedlings showing the unhydrotropic phenotype were collected separately and pooled DNA samples were subkected to the Illumina deep sequencing technology. Bioinformatics were used to identify the exact genomic positions of the mutations (based on a comparison of the genomic sequences of the two Arabidopsis thaliana ecotypes (Columbia and Landsberg). Background: To feed the 9 billion people or more, expected to live on Earth by the mid 21st century, the production of high-quality food must increase substantially. Based on a 2009 Declaration of the World Summit on Food Security, a target of 70% more global food production by the year 2050 was marked, an unprecedented food-production growth rate. Importantly, due to the larger areas of low-yielding land globally, low-yielding environments offer the greatest opportunity for substantial increases in global food production. Nowadays, 70% of the global available water is used by agriculture, and 40% of the world food is produced from irrigated soils. Therefore, much needs to be done towards improving the efficiency of water use by plants, accompanied by increased crop yield production under water-limiting conditions. Major conclusions, solutions and achievements: We established that AtGTL1 (Arabidopsis thaliana GT-2 LIKE1) is a focal determinant in water deficit (drought) signaling and tolerance, and water use efficiency (WUE). The GTL1 transcription factor is an upstream regulator of stomatal development as a transrepressor of AtSDD1, which encodes a subtilisin protease that activates a MAP kinase pathway that negatively regulates stomatal lineage and density. GTL1 binds to the core GT3 cis-element in the SDD1 promoter and transrepresses its expression under water-sufficient conditions. GTL1 loss-of-function mutants have reduced stomatal number and transpiration, and enhanced drought tolerance and WUE. In this case, higher WUE under water sufficient conditions occurs without reduction in absolute biomass accumulation or carbon assimilation, indicating that gtl1-mediated effects on stomatal conductance and transpiration do not substantially affect CO₂ uptake. These results are proof-of-concept that fine-tuned regulation of stomatal density can result in drought tolerance and higher WUE with maintenance of yield stability. Implications: Accomplishments during the IS-4243-09R project provide unique tools for continued discovery research to enhance plant drought tolerance and WUE.
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Innovating and validating measures of complex concepts. Population Council, 2020. http://dx.doi.org/10.31899/sbsr2020.1005.
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Over the past several decades, a number of measures have been developed to assess complex concepts including quality of care (QoC) for family planning (FP) services, anticipated stigma, and gender and power. These measures may predict uptake of health services, contraceptive continuation, and other health-seeking behaviors. Use of these measures may be limited because they are often lengthy and have not undergone extensive assessments for reliability and validity. This brief provides an overview of the Evidence Project's validation of existing measures of QoC for FP and development of a new, shorter measure of QoC; design and validation of a measure of anticipated stigma; and creation of a database of existing measures of gender and power.