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Academic literature on the topic 'COMT'

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Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "COMT"

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&NA;. "COMT inhibitors." Inpharma Weekly &NA;, no. 1135 (May 1998): 6. http://dx.doi.org/10.2165/00128413-199811350-00009.

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Meloto, Carolina B., Samantha K. Segall, Shad Smith, Marc Parisien, Svetlana A. Shabalina, Célia M. Rizzatti-Barbosa, Josée Gauthier, et al. "COMT gene locus." PAIN 156, no. 10 (October 2015): 2072–83. http://dx.doi.org/10.1097/j.pain.0000000000000273.

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O’Tuathaigh, Colm. "S.12.2 - COMT." Behavioural Pharmacology 24 (October 2013): e15. http://dx.doi.org/10.1097/01.fbp.0000434735.74603.db.

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Papaleo, F., M. C. Burdick, J. H. Callicott, and D. R. Weinberger. "COMT–Dysbindin epistatic interaction." Molecular Psychiatry 19, no. 3 (February 21, 2014): 273. http://dx.doi.org/10.1038/mp.2014.6.

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Semen, M. O., O. L. Lychkovska, I. E. Shymanska, V. D. Semen, and H. V. Makukh. "High frequency of the 472AA COMT (Val158) homozygous genotype of the catechol-O-methyltransferase (COMT) gene in children with irritable bowel syndrome." Modern pediatrics. Ukraine, no. 6(126) (October 29, 2022): 23–29. http://dx.doi.org/10.15574/sp.2022.126.23.

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Following the biopsychosocial model of medicine, the pathophysiological basis of irritable bowel syndrome (IBS) is a combination of biological, psychoemotional, and psychosocial factors, the contribution of each of them to the development of this disorder remains unclear. Psychoemotinal factors, which are involved in the pathogenesis of IBS, are caused not only by the environment but also by the metabolism of catecholamines, particularly by the functional activity of catechol-O-methyltransferase (COMT). Purpose - to determine the role of Val158Met COMT polymorphism in development of IBS in children; to identify associations between genotype and clinical variant of the disorder and the nature of the provoking factor. Materials and methods. The material for the molecular genetic study were DNA samples obtained from nuclear cells of venous blood of 54 patients aged 6-12 years with diagnosed IBS. In 48 practically healthy children of the same age DNA samples were isolated from buccal epithelial cells. Molecular genetic study of single nucleotide polymorphism rs4680 of COMT gene was performed by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. Microsoft Excel 2016 and GraphPad Prism 5 software were used for statistical analysis. Results. We have revealed significant differences in the distribution of Val158Met COMT genotypes in children with IBS in comparison with the control group. There was established that the 472GА COMT is more prevalent in healthy children and has a protective role in the development of IBS. In contrast, homozygous genotypes 472GG and 472AA, which are associated with changes in functional activity of enzyme COMT, may be considered as the risk factors for IBS (p≤0.0001). Conclusions. Genotype 472АА COMT was mostly detected in сhildren with stress-associated IBS, which is more related to dysnociception, disorders of cognition, and emotional disturbances. The higher prevalence of 472GA COMT heterozygotes among children with postinfectious IBS and IBS associated with antibiotic therapy indicates a less important role for the psychoemotional component and nociceptive disorders in the onset of this disorder (p=0.03). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
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Adler, Charles H. "COMT Inhibitors: Novel Treatments for Parkinson's Disease." CNS Spectrums 3, no. 2 (February 1998): 53–56. http://dx.doi.org/10.1017/s109285290000554x.

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AbstractCatechol-O-methyltransferase (COMT) inhibitors are a new class of medication being developed for the treatment of Parkinson's disease (PD). The enzyme COMT metabolizes levodopa and dopamine, both peripherally and centrally. Coadministration of a COMT inhibitor with levodopa creates an increase in peripheral and central levodopa bioavailability, as well as higher central dopamine concentrations. Because these actions improve the duration of response to levodopa, the COMT inhibitors should prove to be useful adjunctive therapies in PD patients.
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Belfer, I., and S. Segall. "COMT genetic variants and pain." Drugs of Today 47, no. 6 (2011): 457. http://dx.doi.org/10.1358/dot.2011.47.6.1611895.

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Zammit, Stanley, Michael J. Owen, Jonathan Evans, Jon Heron, and Glyn Lewis. "Cannabis, COMT and psychotic experiences." British Journal of Psychiatry 199, no. 5 (November 2011): 380–85. http://dx.doi.org/10.1192/bjp.bp.111.091421.

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BackgroundA putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.AimsTo examine whether the relative risk of developing psychosis following use of cannabis is dependent upon variation within COMT.MethodA longitudinal study of 2630 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort who completed questionnaire-based assessments for cannabis use at age 14 and incident psychotic experiences at age 16. Six SNPs within COMT were genotyped.ResultsThere was no evidence of an interaction under multiplicative models between cannabis use and COMT on the risk of developing psychotic experiences in our primary analyses. In sensitivity analyses we observed highly variable evidence of interaction, whereby psychotomimetic effects of cannabis were greater in methionine homozygotes under some scenarios, but in valine homozygotes under others.ConclusionsCannabis increases risk of psychosis irrespective of underlying COMT genotypes. These findings argue against the widely held belief that the relative risk of developing psychosis following use of cannabis is dependent upon variation within COMT. The public health message about the potential increase in risk of psychotic disorders following cannabis use should not be tempered by reports that this harm is subgroup specific in the absence of robust evidence of replication.
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Martinez-Martin, P., and C. F. O'Brien. "Extending levodopa action: COMT inhibition." Neurology 50, Issue 6, Supplement 6 (June 1, 1998): S27—S32. http://dx.doi.org/10.1212/wnl.50.6_suppl_6.s27.

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Dorflinger, E., G. Magni, and F. Hoffmann. "COMT inhibition and Parkinson's disease." European Neuropsychopharmacology 8 (November 1998): S87—S88. http://dx.doi.org/10.1016/s0924-977x(98)80057-6.

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Dissertations / Theses on the topic "COMT"

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Gonçalves, Ana Margarida Ribeiro. "Isoformas da enzima catecol-O-metiltransferase como alvo farmacológico na doença de Parkinson." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1636.

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Este trabalho encontra-se dividido em dois Capítulos. O Capítulo 1 aborda o estágio realizado em Farmácia Comunitária, na Farmácia Ferrer de Castelo Branco. Para além de serem descritas as instalações e a sua organização espacial, é apresentada a equipa técnica juntamente com suas funções e abordado de forma geral o sistema informático utilizado (Sifarma 2000). São ainda descritas as várias atividades realizadas durante o estágio, desde a elaboração de encomendas, receção e armazenamento, prestação de cuidados farmacêuticos, elaboração de medicamentos manipulados, dispensa de medicamentos sujeitos e não sujeitos a receita médica, faturação, entre outros. A legislação farmacêutica, implicada na prática farmacêutica é explorada também neste capítulo. O Capítulo 2, aborda uma revisão bibliográfica sobre as isoformas da enzima catecol-O-metiltransferase como alvo farmacológico na doença de Parkinson. A doença de Parkinson é uma doença neurodegenerativa, na qual está envolvida a perda dos neurónios dopaminérgicos da substancia nigra (pars compacta). Afeta cerca de 1% da população mundial com mais de 65 anos e pensa-se que fatores genéticos e ambientais estejam na sua origem. A catecol-O-metiltransferase (COMT) está presente tanto em eucarióticos, como em procarióticos. É uma proteína intracelular e nos mamíferos encontra-se distribuída uniformemente pelo organismo, apresentando maior atividade no fígado, rim e trato gastrointestinal. Tem como função, o metabolismo de moléculas com estrutura catecólica biologicamente ativas, sejam elas endógenas ou exógenas. Apresenta vários polimorfismos, sendo que o polimorfismo em que está implicada a substituição de Valina por Metionina é o único em que a função é conhecida. Manifesta-se na forma de duas isoformas, a forma solúvel (S-COMT) e a forma membranar (MB-COMT), sendo a forma solúvel a mais predominante no organismo, com exceção do cérebro. Para além da distribuição no organismo, elas diferem também na localização subcelular, propriedades cinéticas, especificidade com o substrato e peso molecular. A levodopa é considerada a terapêutica mais eficaz na doença de Parkinson, desde a década de 60. É administrada com inibidores da descarboxilase de ácidos aminados aromáticos (DAAA). Em doentes que apresentem flutuações motoras, são co-administrados inibidores da COMT. Atualmente o entacapone é o inibidor mais utilizado, no entanto, o opicapone, em Fase III dos ensaios clínicos, apresenta uma maior inibição, sendo que é necessária apenas uma única dose diária, ao contrário do entacapone.
This work is divided in two chapters. Chapter I covers the stage held in Community Pharmacy, on Pharmacy Ferrer - Castelo Branco. Besides describing the facilities and their spatial organization, the technical team and its functions, there is an approach to the informatics system used (Sifarma 2000), and there are also described the various activities carried out during the stage, from the ordering process, reception and storage, providing pharmaceutical care, preparation of compounded medications, dispensing prescribed and non-prescribed medications, billing, among others. Pharmaceutical legislation, involved in pharmaceutical practice is also explored in this chapter. Chapter 2 covers a bibliographic review on the isoforms of catechol-O-metiltransferase enzyme as pharmacological target in Parkinson's disease. Parkinson's disease is a neurodegenerative disease, which is involved in the loss of dopaminergic neurons of the substantia nigra (pars compacta). It affects about 1% of the population over 65 years and it is thought that genetic and environmental factors are at their origin. The catechol-O-methyltransferase (COMT) is present in both eukaryotic and prokaryotic. It is an intracellular protein, and in mammals is distributed uniformly throughout the body, presenting highest activity in the liver, kidney and gastrointestinal tract. Its main function is the metabolism of molecules with catechol structure biologically active, whether endogenous or exogenous. Presents several polymorphisms, where the polymorphism involved in the replacement of Valine by Methionine is the only one in which the function is known. Manifests as two isoforms, the soluble form (S-COMT) and the membrane form (MB-COMT), being the soluble form more prevalent in the body, except the brain. In addition to the distribution in the body, they also differ in subcellular localization, kinetic properties, substrate specificity and molecular weight. Levodopa is considered the most effective therapy in Parkinson's disease, since the 60s. It is administered with decarboxylase inhibitors of aromatic amino acid (DAAA). In patients with motor fluctuations, is co-administered with COMT inhibitors. Currently entacapone is the only available inhibitor, however, opicapone, in the third Phase of clinical trials, presents a greater inhibition, in which a single daily dose is enough, unlike entacapone.
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Andersson, Anneli. "Katekol-O-Metyltransferas (COMT), tidigare övergrepp, gen-miljöinteraktion i förutsägelsen för våld." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42712.

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Flera kandidatgener har föreslagits spela en roll i utvecklingen av antisociala beteenden i samband med miljöfaktorer. Syftet med den föreliggande studien var därmed att undersöka sambandet mellan genen Katekol-O-Metyltransferas (COMT) och våld; och om det fanns interaktioner mellan exponering för tidigare övergrepp och COMT i samband med senare våld. Data hämtades från en Svensk populationsbaserad studie baserad på 2500 20-24 åringar. Den aktuella studien fann att beroende på vilken variant av genen man besitter, kommer man att påverkas i olika grad av negativa miljöfaktorer såsom försummelse och sexuella övergrepp i samband med våld.
Several candidate genes have been suggested to play a role in the development of antisocial behavior in association with social and environmental factors. Therefore, the purpose of the present study was to investigate the relationship between the gene Catechol-O-Methyltransferase (COMT) and violence; and to examine whether there were interactions between earlier abuse and COMT in the association of violence. Data were drawn from a Swedish population-based study including 2,500 20-24 year olds. The present study found that depending on which variant of the gene one possess, one will be affected to different degree of adverse environmental factors in association with violence.
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CASTELLANO, FILIPPO. "Funzioni Esecutive e Facial Emotion Recognition in Persone Affette da Schizofrenia: ruolo del Polimorfismo del COMT e dell'Abuso di Alcol e Sostanze." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94538.

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BACKGROUND: le caratteristiche cognitive e genetiche sono sempre più centrali nello studio della Schizofrenia. La compromissione delle Funzioni Esecutive (FE), definite come un complesso di abilità cognitive superiori attribuibili alle regioni della corteccia prefrontale, e della Facial Emotion Recognition (FER) rappresentano elementi centrali nel disturbo schizofrenico. Ad oggi, però, il paradigma del (dis)funzionamento cognitivo nella Schizofrenia poggia su studi che hanno escluso i soggetti schizofrenici con storia di abuso di sostanze (SUD), che ha mostrato un impatto peggiorativo sulla cognitività nella popolazione con disturbo da uso di sostanze. La letteratura ha inoltre negli anni definito polimorfismi potenzialmente implicati sia nella Schizofrenia sia nei disturbi da uso di alcol e sostanze, come quello (rs4680) relativo al gene della catecol-O-metiltransferasi (COMT). Viste la prevalenza del fenomeno e l’associazione fra cognition, outcome funzionale e le polimorfismi genetici, lo studio di tali correlati nei pazienti schizofrenici con abuso di sostanze costituisce una questione imprescindibile per una più puntuale stratificazione diagnostica, prognostica e dei trattamenti. SCOPO DEL LAVORO: valutare l’impatto del polimorfismo del COMT e dell’abuso di alcol e sostanze sulle performance cognitive in una popolazione di soggetti con schizofrenia. MATERIALI E METODI: si tratta di uno studio descrittivo­osservazionale. Sono stati reclutati 62 soggetti (M=50; F=12) con diagnosi di Schizofrenia secondo il DSM-IV (valutata attraverso la Structured Clinical Interview for DSM­IV, SCID I). Il campione è stato suddiviso a seconda della presenza o meno dell’abuso di alcol e sostanze correlato (valutato con l’Alcohol e la Drug Use Scale -AUS e DUS­) in due gruppi, che sono stati poi confrontati per quanto riguarda le caratteristiche socio­demografiche e cliniche (Positive and Negative Syndrome Scale - PANSS­). È stata analizzata quindi l’associazione tra condizione di abuso, polimorfismo del COMT e risultati ottenuti all’Intra-Extra Dimensional Set Shift (IED), che valuta le FE e il test di Ekman, che valuta la FER, controllando per variabili socio­demografiche e cliniche. RISULTATI: I due gruppi SKZ+SUD (n=28) e SKZ-SUD (n=34) presentano una differenza statisticamente significativa per età con media (SD) pari a 47.21 (9.41) negli abusatori e 36.04 (10.09) nei non abusatori (p<0.001). All’IED gli abusatori tendono a compiere meno errori (IED Total errors adjusted 47.32 (47.77) vs 70.59 (70.84); p=0.26), un minor numero di prove (IED Total trials adjusted 136.61 (85.65) vs 178.35 (128.02); p=0.24) per raggiungere il criterio necessario a superare gli stage e un maggior numero di stage completati (IED stages completed 7.79 (2.11) vs 6.85 (3.12); p=0.35) Al test di Ekman il gruppo degli abusatori (media=41.86 (7.50)) mostra un punteggio statisticamente più alto (p=0.02) rispetto ai non abusatori (media=35.29 (11.79). All’IED (stage completati), controllando per la PANSS, il genotipo Met-Met rispetto al genotipo Val-Val è diverso nel gruppo di abuso rispetto allo stesso confronto nel gruppo di non abuso (interazione con coefficiente -4.09 CI [-8.06, -0.13]; p=0.043): Met-Met mostra una performance peggiore rispetto a Val-Val nel gruppo di abuso. Lo stesso tipo di interazione è confermata anche per quanto riguarda il test di Ekman, pur non raggiungendo la significatività statistica (interazione con coefficiente -6.46 CI [-0.83, 13.76]; p=0.081). CONCLUSIONI: I soggetti schizofrenici con abuso si sono dimostrati tendenzialmente meno compromessi sotto il profilo neuropsicologico rispetto a quelli senza abuso. Inoltre si è evidenziata un’interazione tra il polimorfismo per il gene COMT e la condizione di abuso di alcol e sostanze per quanto riguarda le performance relative alle FE e alla FER.
BACKGROUND: cognitive and genetic features are increasingly important in the study of schizophrenia. The impairment of executive function (FE) and facial emotion recognition, are central issues in schizophrenic disease. To date, however, the paradigm of the (dis) cognitive functioning in schizophrenia is based on studies that excluded subjects with schizophrenia and a history of substance abuse (SUD)(5), which is actually a phenomenon that showed a derogatory impact on cognition in the population with substance use disorder. The literature has also over the years defined polymorphisms potentially implicated in both schizophrenia and in alcohol and substance use disorders, such as the one (rs4680) related to the gene of catechol-O-methyltransferase (COMT). Given the prevalence of the phenomenon and the association between cognition, functional outcome and genetic polymorphisms, the study of these related in schizophrenic patients with substance abuse is an important issue for a more precise stratification diagnosis, prognosis and treatment. AIM: to evaluate the impact of the COMT polymorphism and alcohol and substance abuse on cognitive performance in a population of subjects with schizophrenia. MATERIALS AND METHODS: this is a observational study. We recruited 62 subjects (M = 50, F = 12) diagnosed with schizophrenia according to DSM-IV (assessed by the Structured Clinical Interview for DSM-IV, SCID I). The sample was subdivided according to the presence or not of alcohol abuse and related substances (evaluated with the Alcohol and Drug Use Scale -Aus and DUS) into two groups (SKZ+SUD and SKZ-SUD), which were then compared with regard to socio-demographic and clinical characteristics (Positive and Negative Syndrome Scale - PANSS). It was then analysed the association between the condition of abuse, COMT polymorphism and score on Intra-Extra Dimensional Shift September (IED), which evaluates the FE and on test Ekman, evaluating the FER, controlling for socio-demographic and clinical variables. RESULTS: the two groups SKZ+SUD (n= 8) and SKZ-SUD (n = 34) show a statistically significant difference by age with mean (SD) of 47.21 (9.41) in abusers and 36.04 (10.09) in non-abusers (p <0.001). Abusers tend to make fewer errors on IED (IED errors adjusted Total 47.32 (47.77) vs 70.59 (70.84); p = 0:26), fewer trials (IED trials Total Adjusted 136.61 (85.65) vs 178.35 (128.02); p = 0:24) to reach the criterion to overcome the stage and a greater number of stages completed (IED stages completed 7.79 (2.11) vs 6.85 (3.12), p = 0:35). Abusers (mean = 41.86 (7:50)) show a score statistically higher (p = 0.02) compared with non-abusers (mean = 35.29 (11.79) on Ekman test. On IED (stage completed), checking for the PANSS, the Met-Met genotype compared with Val-Val genotype was different in the group of abuse compared with the group not abusing (interaction coefficient -4.09 CI [-8.06, -0.13]; p = 0.043): Met-Met show a worse performance than in the group of Val-Val. The same type of interaction is confirmed also with regard to the Ekman , although not reaching statistical significance (interaction with coefficient -6.46 CI [-0.83, 13.76]; p = 0.081). CONCLUSIONS: subjects with schizophrenia and substance abuse seems to be less compromised from a neuropsychological point of view than those without abuse. Furthermore it is shown an interaction between the polymorphism for COMT gene and the condition of alcohol and substance abuse with regard to the FE and FER performance.
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da, Silva Costa Isis. "Variations in EEG and motor functions related to COMT gene in patients with fibromyalgia." Doctoral thesis, Universitat de les Illes Balears, 2017. http://hdl.handle.net/10803/399443.

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La fibromialgia (FM) es un síndrome crónico caracterizado por dolor generalizado, fatiga, sueño no reparador, quejas somáticas y alteraciones afectivas y cognitivas. Aunque existe evidencia reciente indicando que las emociones negativas pueden desempeñar un papel modulatorio relevante para el mantenimiento de los síntomas de la FM, poco se conoce de la influencia de los polimorfismos genéticos sobre la función motora, el sueño y el procesamiento afectivo en fibromialgia. El objetivo principal de esta tesis fue analizar la influencia del polimorfismo val158met del gen de la COMT, que se encuentra asociado a la actividad enzimática de la degradación de catecolaminas, sobre la marcha y el equilibrio, el sueño y la regulación emocional. Para ello, se ha adoptado un enfoque multidisciplinar en el que se ha tenido en cuenta parámetros biomecánicos de la función motora, la actividad cerebral durante el sueño y durante la modulación afectiva del reflejo de sobresalto para comparar individuos que muestran bien una baja o una alta actividad de COMT (homocigotos met y portadores del alelo val, respectivamente). La función motora fue evaluada mediante el análisis de la marcha y el equilibrio con grabaciones de videos en personas sanas y pacientes con FM (estudio 1). Además, dos subgrupos de pacientes con FM basados en el polimorfismo de la COMT participaron en un registro nocturno de polisomnografía (estudio 2) y una tarea experimental con la presentación de estímulos acústicos de sobresalto durante la visualización de imágenes afectivas (estudio 3). El estudio 1 mostró que las pacientes con FM presentan una reducción significativa en los parámetros de la marcha tales como velocidad, longitud del paso y del paso completo, o la cadencia, así como déficits en el control postural y el equilibrio. El estudio 2 reveló que las pacientes con FM y baja actividad de la enzima COMT parecen estar más impactadas físicamente, más deprimidas y con peor calidad de sueño (mayor número de despertares durante la noche, mayor tiempo en la cama y sueño más fragmentado durante la fase REM) que las pacientes con FM y alta actividad de la enzima COMT. Por último, el estudio 3 mostró que las pacientes con FM y baja actividad de la enzima COMT presentan alteraciones significativas de los componentes tempranos de la actividad cerebral desencadenada por estímulos agradables y desagradables comparadas con las pacientes con FM y alta actividad de la COMT. Estos estudios sugieren: 1) que la marcha y el equilibrio se encuentran alterados en las pacientes con FM comparadas con personas sin dolor, y 2) que el sueño y el procesamiento afectivo en las pacientes con FM puede ser modulado por el polimorfismo val158met del gen de la COMT que regula la actividad enzimática de las catecolaminas. En resumen, estos hallazgos proporcionan un apoyo adicional a la idea de que los síntomas de la fibromialgia precisarían de una evaluación y de una intervención terapéutica de carácter multidimensional con el objetivo de proporcionar las óptimas condiciones para la mejora de la calidad de vida de estos pacientes. Asimismo, estos hallazgos subrayan la relevancia de considerar marcadores genéticos y neurofuncionales para una compresión más completa del síndrome de fibromialgia.
La fibromialgia (FM) és una síndrome crònica caracteritzada per dolor generalitzat, fatiga, son no reparador, queixes somàtiques i alteracions afectives i cognitives. Encara que existeixen evidències indicant que emocions negatives poden tenir un paper modulador rellevant en el manteniment dels símptomes de la FM, poc es coneix de la influència dels polimorfismes genètics sobre la funció motora, el son i el processament afectiu en la fibromiàlgia. L’objectiu principal d’aquesta tesi doctoral va ser analitzar la influència del polimorfisme val158met del gen de la COMT, que es troba associat a l’activitat enzimàtica de la degradació de les catecolamines, sobre la marxa i l’equilibri, el son i la regulació emocional. Per això, s’ha adoptat un enfocament multidisciplinari en el qual s’han tingut en conte paràmetres biomecànics de la funció motora, l’activitat cerebral durant el son i durant la modulació afectiva del reflex de sobresalt per comparar subjectes que mostren una baixa o alta activitat de COMT (homozigots met i portadors d’al·lel val, respectivament). La funció motora fou avaluada mitjançant l’anàlisi de la marxa i l’equilibri amb gravacions de video en persones sanes i en pacients amb FM (estudi 1). A més, dos grups de pacients amb FM basats en el polimorfisme de la COMT participaren en un registre polisomnogràfic nocturn (estudi 2), i en una tasca experimental ambla presència d’estímuls acústics de sobresalt durant la visualització d’imatges afectives (estudi 3). L’estudi 1 mostrà que les pacients amb FM presenten una disminució significativa en paràmetres de la marxa com són la velocitat, la longitud de cada pas i del pas complet o cadència, així com dèficits en el control postural i de l’equilibri. L’estudi 2 desvetllà que les pacients amb FM amb baixa activitat de l’enzim COMT pareixen estar més impactades físicament, més deprimides i amb pitjor qualitat de son (major nombre de despertars durant la nit, major quantitat de temps en el llit i un son més fragmentat durant la fase REM), que les pacients amb FM amb alta activitat de l’enzim COMT. Per últim, l’estudi 3 mostrà que les pacients con FM amb baixa activitat de l’enzim COMT presenten alteracions significatives en els components primerencs de l’activitat cerebral desencadenada per estímuls agradables o desagradables, comparades amb les pacients con FM amb alta activitat del COMT. Aquests estudis suggereixen: 1) la marxa i l’equilibri es troben alterats en les pacients amb FM comparades amb les persones sense dolor, i 2) que el son i el processament afectiu de les pacients amb FM port estar modulat pel polimorfisme val158met del gen del COMT que regula l’activitat enzimàtica de les catecolamines. En resum, aquests resultats remarquen encara més la idea de que els símptomes de la fibromiàlgia precisen d’una avaluació i d’una intervenció terapèutica de caràcter multidimensional amb l’objectiu de proporcionar les òptimes condicions per la millora de la qualitat de vida d’aquetes pacients. Així mateix, aquestes troballes subratllen la rellevància de considerar els marcadors genètics i neurofuncionales per a una compressió més completa de la síndrome de fibromiàlgia.
Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain, fatigue, unrefreshing sleep, somatic complaints, and affective and cognitive alterations. Although there is recent evidence indicating that negative affect may play a relevant modulatory role for the maintenance of fibromyalgia symptoms, little is known about how genetic polymorphisms may influence motor function, sleep and affective processing in fibromyalgia. The major goal of the present thesis was to analyze the influence of the val158met polymorphism of the COMT gene which is associated with the enzymatic activity level of cathecolamine degradation on gait and balance, sleep and emotional regulation. For this purpose, a multidisciplinary approach taking into account biomechanical parameters of motor function and parameters of the brain activity during sleep and during affective processing was used to compare individuals displaying either low (met homozygotes) or high COMT activity (val carriers). Motor function was assessed by analyzing gait and balance through video recordings in healthy controls and FM patients (study 1). In addition, two subsamples of FM patients based on the val158met polymorphism participated in a night polysomnography recording (study 2) and an experimental task with presentation of startle noise stimuli when viewing affective pictures (study 3). Study 1 showed that FM patients display a significant reduction in gait parameters such as speed, step length and full step, cadence and etc., as well as deficits in postural control and balance. Study 2 revealed that FM patients with low-activity of the COMT enzyme appear to be more physically impacted and depressed, and to have poorer quality of sleep (greater number of awakenings during the night, longer in bed and more fragmented sleep during REM) than FM patients with high-activity of the COMT enzyme. Finally, Study 3 showed that patients with low-activity of the COMT enzyme display significant alterations of the early components of the event-related brain potentials elicited by pleasant and unpleasant stimuli as compared with FM patients displaying high COMT activity. These studies suggest: 1) that gait and balance are altered in patients with FM compared to pain-free controls, and 2) that sleep and affective processing in FM patients may be modulated by the val158met polymorphism of the COMT gene that regulates the enzyme activity of catecholamines. In summary, these findings provide further support for the notion that FM symptoms would require multidimensional assessment and intervention to provide optimal conditions for improving quality of life in these patients. Moreover, our findings underline the relevance of considering genetic and neurofunctional markers for a complete understanding of fibromyalgia.
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Barbosa, Marta Cristina Fornelos. "Sistema Nervoso Central: planeamento químico-farmacológico para obtenção de um novo alvo terapêutico para a doença de Parkinson." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3205.

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Trabalho apresentado à Universidade Fernando Pessoa como parte integrante dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
O presente trabalho pretende seguir uma linha de investigação pré-laboral, mas de enorme potencial devido à possibilidade de apresentar uma significativa redução nos custos aquando do lançamento de uma nova solução terapêutica. O trabalho será desenvolvido na área do sistema nervoso central (SNC) e a doença abordada será a doença de Parkinson. No decorrer deste trabalho irá ser feito uma abordagem ao tratamento farmacológico da DP, e realizado um estudo químico-farmacológico de potenciais novos inibidores da COMT. A Doença de Parkinson (DP) é uma patologia cerebral em que ocorre morte dos neurónios numa zona do cérebro designada de substância negra. É a segunda doença neurodegenerativa mais frequente depois da doença de Alzheimer. This work intends to pursue a line of pre-employment investigation, but with great potential due to the possibility of presenting a significant cost reduction at the launch of a new therapeutic solution. The work will be developed in the area of the central nervous system (CNS) and the disease discussed will be Parkinson's disease. We will make an approach to the pharmacological treatment of PD, and we will conduct a chemical and pharmacological study of potential new COMT inhibitors. Parkinson's disease (PD) is a brain pathology in which occurs neuronal death in an area of the brain called substantia nigra. It is the second most common neurodegenerative disorder after Alzheimer's disease.
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Ho-Yue-Kuang, Séverine. "Exploration des voies de biosynthèse de l’acide férulique dans les grains et tiges de Brachypodium distachyon." Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=ed667b2c-bd04-465a-bea7-b1ae49162a58.

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L’acide férulique joue un rôle clé dans les parois cellulaires des Poaceae en permettant la réticulation des chaînes de polysaccharides entre elles et avec les lignines. La connaissance de sa biosynthèse peut améliorer l’usage des céréales en permettant de moduler les propriétés mécaniques des parois et leur digestibilité enzymatique. La plante modèle des Poaceae, Brachypodium distachyon, a été utilisée pour explorer les voies de synthèse de l’acide férulique. Une stratégie de génétique inverse a été mise en place afin d’étudier deux enzymes candidates, la COMT et la CCoAOMT sélectionnées pour leur capacité à produire in vitro respectivement l’acide férulique et le féruloylCoA. Ces OMT étant codées par des familles multigéniques, la sélection des gènes candidats a été basée sur des analyses phylogénétiques et transcriptomiques. Des lignées mutantes ont été obtenues par mutagenèse chimique et identifiées par TILLING pour le gène BdCOMT6. L’analyse de ces lignées a montré que BdCOMT6 est une COMT impliquée dans la synthèse des lignines des tiges et des grains de B. Distachyon. Elle ne serait pas impliquée dans la synthèse de l’acide férulique lié aux parois. Des lignées d’interférence ARN ciblant cinq gènes CCoAOMT appartenant à un clade spécifique des Poaceae ont été générées. De l’acide férulique lié aux parois a été détecté dans les tiges des plantes régénérées. L’analyse des générations suivantes est en cours pour déterminer la fonction de ces gènes. Les lignines des tiges de B. Distachyon ont été étudiées en détail ces dernières années, ce travail de doctorat a permis de caractériser pour la première fois les structures des lignines présentes dans les grains
Ferulic acid plays a key role in grass cell walls, allowing the reticulation between chains of polysaccharides and with lignins. The understanding of its biosynthesis could improve cereals end-uses in allowing the modulation of the cell wall mechanical properties and enzymatical digestibility. The model plant of Poaceae, Brachypodium distachyon, was used to explore the ferulic acid biosynthesis pathways. A reverse genetic strategy has been established to study two candidate enzymes, the COMT and the CCoAOMT selected for their capacity to produce in vitro ferulic acid and feruloylCoA respectively. Since these OMTs are encoded by multigenic families, a selection of candidate genes has been performed based on phylogenetic and transcriptomic analyses. Mutant lines have been obtained through chemical mutagenesis and identified by TILLING for the BdCOMT6 gene. The analysis of these lines showed that BdCOMT6 is a COMT involved in lignin biosynthesis in B. Distachyon stems and grains. However it would not produce the ferulic acid linked to cell walls. RNA interference lines targeting five CCoAOMT genes belonging to a Poaceae specific clade have been generated. Ferulic acid linked to stem cell walls was detected by preliminary analyses of the regenerated plants. Complementary analyses of the next generations are in progress, they will allow to determine if these CCoAOMT genes have a role in the biosynthesis of ferulic acid linked to cell wall. Lignins have been studied in details over the last few years, only stem lignins were characterized in B. Distachyon, this doctoral work allowed to precisely characterize, and for the first time, the structure of the grain lignins
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Kawa, Kevin Hideyuki, and Kevin Hideyuki Kawa. "Genetic and Neuroanatomic Factors that Influence Executive Functions in Aging." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/622974.

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In the present set of experiments, we investigated the effects of age and COMT genotypes on traditional measures of executive functions, e.g., Wisconsin Card Sorting Test (WCST; Hart et al., 1988), a battery of executive functions based on the 3 factor model (shifting, updating, inhibition) described by Miyake et al. (2000) and developed at the University of Arizona (Alexander et al., 2012), and two fMRI tasks of executive functions (shifting, updating). The results of experiment 1 showed that COMT influenced performance on several traditional measures of executive functions, with Met homozygotes outperforming Val homozygotes. However, on the WCST we did not observe less perseverative errors in Met carriers as reported previously (Barnett, Jones, Robbins, & Muller, 2007; Bruder et al., 2005; Malhotra et al., 2002; Nagel et al., 2008). According to Miyake et al. (2000), however, such tasks as the WCST may actually involve multiple executive processes, making it difficult to tease apart the different types of executive functions being measured. Furthermore, COMT may be sensitive to some aspects of executive functions and not others. To this end, in experiment 2 we investigated associations between COMT and measures of executive functions from each of the 3 domains described in Miyake et al. (2000). According to the models proposed by Bilder et al. (2004) and Cools and D’Esposito (2011), the Val allele promotes cognitive flexibility, while the Met allele promotes cognitive stability. Contrary to what we expected, Met homozygotes actually performed better than Met/Val heterozygotes but no better than Val homozygotes on one measure of updating (flexibility). Upon closer examination of the processes involved in the updating task, however, the results may not necessarily be contradictory as the task may have required greater stability than previously thought. In the fMRI experiment, although behavioral performance was largely similar between age groups and COMT genotypes on the fMRI tasks, we observed differences in activation such that younger adults and Met homozygotes showed higher levels of activation relative to older adults and Val carriers, respectively. Our results suggest that these higher levels of activation may have been relied upon to maintain similar levels of performance. Additionally, across the 3 experiments the effects of COMT indicate that an overall Met advantage cannot be assumed. Rather, the benefits of one allele compared to the other should be investigated in terms of the specific cognitive processes involved in the task at hand. Thus, it is important for future studies to continue characterizing the unity and diversity of executive functions and investigate factors that may influence these patterns behaviorally and neurally, such as age and genetics.
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Stitzinger, Johannes. "Der Einfluss genetischer Variationen im COMT Gen auf kognitive Phänotypen." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-59417.

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Laatikainen, Linda Maria. "The role of catechol-O-methyltransferase (COMT) in hippocampal function." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d0c9e1fa-a052-4af7-aaff-00548365e024.

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Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes. First, as part of a study investigating the role of COMT in schizophrenia, human hippocampal COMT mRNA levels were shown to be neither altered in schizophrenia or bipolar disease, nor affected by COMT genotype. Hence, functional COMT polymorphisms do not appear to operate by altering gross COMT mRNA expression. Importantly, this study showed that COMT is expressed in the human hippocampus. Second, the role of COMT in hippocampal neurochemistry was explored by studying the effect of pharmacological COMT inhibition on catecholamines and metabolites in rat hippocampal homogenates, and extracellularly, using microdialysis. Both demonstrated that COMT modulates hippocampal dopamine metabolism. Thus, hippocampal COMT is of functional significance with respect to dopamine. Third, the effect of COMT inhibition on hippocampus-dependent behaviour was investigated. The results suggested a memory-enhancing effect of pharmacological COMT inhibition on hippocampus-dependent associative and non-associative forms of short-term memory in rats. In contrast, acute COMT inhibition appeared to have no effect on behavioural correlates of ventral hippocampal function i.e. anxiety-like behaviour. In summary, the expression of COMT mRNA in the human hippocampus, as well as the effect of COMT inhibition on rat hippocampal neurochemistry and hippocampus-dependent behaviour provide evidence for a functional role of COMT in the hippocampus. Moreover, changes in COMT activity alter hippocampal dopamine metabolism, which could be a potential mechanism for the role of COMT in hippocampus-dependent short-term memory.
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Soares, Rui Filipe Lopes. "Biosynthesis of human membrane-bound Catechol-O-methyltransferase: optimization using Plackett-Burman and Central Composite Design." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1120.

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Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is an S-adenosyl-L-methionine-dependent methyltransferase enzyme that catalyzes the methylation of catechol substrates (catecholamines, catecholestrogens). Physiologically, it is responsible for the elimination of biologically active or toxic catechols, making it a protein with great clinical relevance as therapeutic target in serious disorders, like schizophrenia and Parkinson´s disease. To fulfill pharmaceuticals requirements, new strategies of optimization and large-scale production of COMT enzyme are crucial. Statistical optimization approaches have demonstrated their enormous value in laboratory and industrial scale, namely in biotechnological production processes, in which an incremental enhancement can be a perpetual improvement. In this work, we aimed the optimization of recombinant human membrane-bound COMT (hMBCOMT) enzymatic activity yields following a statistical optimization as a solving approach. Plackett-Burman design was used as a first optimization step to identify which factors have a significant effect in hMBCOMT productivity and activity levels, and Response Surface Methodology (RSM), by a Central Composite Design (CCD), to optimize the process. We applied Brevibacillus choshinensis cells for the biosynthesis of hMBCOMT and a semi-defined medium for cell growth. This medium was subjected to a first screening using the Plackett–Burman design to evaluate the influence of the culture parameters (chemicals and physicals) in hMBCOMT enzymatic activity levels. Enzymatic activity were measured in a high performance liquid chromatography (HPLC) coupled to a coulochemical detector. Among the eleven variables tested, polypeptone, ammonium sulfate, glucose and temperature were selected owing to their significant effect on human MBCOMT enzymatic activity. The biological human MBCOMT activity obtained with the semi-defined medium in Plackett-Burman design were very promising, while were higher than the obtained with 2SYNm medium, a traditional growth medium for Brevibacillus cells of this work. Typically, we obtained values of 93nmol/h for hMBCOMT total enzymatic activity and 30 nmol/h/mg of specific activity with protein in its native form, without the use of any kind of detergents on protein solubilization step. Based on the results of Plackett–Burman design, a CCD was adopted to define optimal components concentration and temperature in order to maximize our response. The CCD model presented a multiple correlation coefficient value of 0.635 and a significant lack of fit, showing the lack aptness of the model to the process optimization and the failure to attain the optimal concentration of each variable.
Catecol-O-metiltransferase (COMT, CE 2.1.1.6) é uma enzima metiltransferase dependente de S-adenosil-L-metionina (SAM) que catalisa a metilação de substratos catecóis (catecolaminas, catecolestrogénios). Fisiologicamente, é responsável pela eliminação de catecóis biologicamente activos ou tóxicos, tornando-a uma proteína de elevado interesse clínico e utilizada como alvo terapêutico em doenças graves, como a esquizofrenia e a doença de Parkinson. Para suprir as necessidades farmacêuticas, novas estratégias de otimização e produção em larga escala desta enzima são fundamentais. Abordagens de otimização estatística têm demonstrado o seu enorme valor à escala laboratorial e industrial, nomeadamente nos processos de produção biotecnológicos, em que um pequeno detalhe melhorado pode significar um grande passo para o sucesso. Neste trabalho, objetivou-se a otimização do nível de atividade enzimática da proteína recombinante COMT, na sua forma membranar, através do recurso a modelos de otimização estatística como uma abordagem resolutiva. Numa primeira fase de otimização e de seleção dos fatores mais significativos para a atividade enzimática da proteína em estudo foi utilizada a técnica de desenho experimental Plackett-Burman. Após esta seleção foi aplicada a Metodologia de Superfície de Resposta (RSM), através de desenho composto central (DCC), para otimização da concentração dos fatores que revelaram ser mais significativos e, consequentemente, do processo. Foi utilizado o sistema de expressão Brevibacillus choshinensis para a biossíntese da proteína membranar COMT e um meio semi-definido para o seu crescimento. Este meio foi submetido a uma primeira triagem através do desenho experimental Plackett-Burman, avaliando-se desta forma a influência dos parâmetros de cultura (produtos químicos e físicos) nos níveis de actividade enzimática da COMT membranar. Os níveis de actividade enzimática foram medidos num sistema de cromatografia líquida de alta eficiência acoplado a um detector amperométrico. Entre as onze variáveis testadas, a polipeptona, sulfato de amónio, glucose e temperatura foram as variáveis selecionadas dado o seu significativo efeito na actividade enzimática da COMT membranar. Os níveis de atividade enzimática obtidos nesta primeira triagem revelaram-se bastante promissores, sendo mais elevados do que os obtidos com o meio 2SYNm, meio de crescimento mais comum para as células usadas neste trabalho. Foram obtidos valores de 93nmol/h para a actividade enzimática total e cerca 30 nmol/h/mg de actividade enzimática específica com a proteína na sua forma nativa, sem o uso de qualquer tipo de detergentes no processo de solubilização. Com base nos resultados do desenho Plackett Burman foi aplicado o desenho Composto Central para a otimização dos quatro fatores em causa a fim de maximizar a nossa resposta. Este apresentou um valor do coeficiente de correlação múltipla de 0,635 e uma falta de ajuste significativa, demonstrando a falta de adequação do modelo para a otimização do processo.
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Books on the topic "COMT"

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Royal Society of Medicine (Great Britain), ed. Parkinson's disease: Extending the effectiveness of levodopa through COMT and MAO-B inhibition. London: Royal Society of Medicine Press, 2006.

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Oliver, Cookie Dawkins. Come Comet, come Cupid. Nashville, TN: Winston-Derek Publishers, 1992.

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Winn, Steven. Come Back, Como. New York: HarperCollins, 2009.

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Proença, Ruy. Como um dia come o outro. São Paulo, SP, Brasil: Nankin Editorial, 1999.

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J, Brinker Barry, ed. Guide to cost management. New York: Wiley, 2000.

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Yi, Li Yuyao, ed. Hui lai ba, Ke mo: Come back, Como. Nanjing: Yi lin chu ban she, 2011.

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Shaffer, Marvin. Multiple account benefit-cost analysis: A practical guide for the systematic evaluation of project and policy alternatives. Toronto: University of Toronto Press, 2010.

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Cutting costs effectively in recession & recovery. [United States?]: RecessionStormingMedia, 2009.

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Shaffer, Marvin. Multiple account benefit-cost analysis: A practical guide for the systematic evaluation of project and policy alternatives. Toronto: University of Toronto Press, 2010.

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Anderson, Lee G. Analyse coûts-avantages: Un guide pratique. Sillery, Qué: Presses de l'Université du Québec, 1990.

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Book chapters on the topic "COMT"

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Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola, et al. "COMT Inhibitor." In Encyclopedia of Psychopharmacology, 324. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_948.

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Peter, Helga, and Thomas Penzel. "COMT-Hemmer." In Springer Reference Medizin, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_407-1.

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Männistö, P. T., I. Ulmanen, K. Lundström, J. Taskinen, J. Tenhunen, C. Tilgmann, and S. Kaakkola. "Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, 291–350. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7144-0_9.

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O’Tuathaigh, Colm M. P., Lieve Desbonnet, and John L. Waddington. "Cannabinoids, Monoamines, COMT and Schizophrenia: Pathobiological Mechanisms in Psychosis." In Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, 297–323. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7940-6_14.

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He, Zhaohui, Xiaochuan Sun, Zongduo Guo, and John H. Zhang. "Expression and Role of COMT in a Rat Subarachnoid Hemorrhage Model." In Early Brain Injury or Cerebral Vasospasm, 181–87. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0353-1_32.

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Valente, Nina Leão Marques, Jose Paulo Fiks, and Marcelo Feijó de Mello. "Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD." In Comprehensive Guide to Post-Traumatic Stress Disorders, 1019–31. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-08359-9_27.

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Valente, Nina Leão Marques, Jose Paulo Fiks, and Marcelo Feijó de Mello. "Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD." In Comprehensive Guide to Post-Traumatic Stress Disorder, 1–11. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-08613-2_27-1.

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Zürcher, G., A. Colzi, and M. Prada. "Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues." In Amine Oxidases and Their Impact on Neurobiology, 375–80. Vienna: Springer Vienna, 1990. http://dx.doi.org/10.1007/978-3-7091-9113-2_51.

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Kostić, Vladimir S. "COMT Inhibition in the Treatment of Parkinson’S Disease: Neuroprotection and Future Perspectives." In Advances in Experimental Medicine and Biology, 75–90. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-8969-7_5.

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Ruß, H. M., W. Kuhn, and H. Przuntek. "Der Einfluß von R-(-)-Deprenyl auf die COMT-Aktivität beim Morbus Parkinson." In Verhandlungen der Deutschen Gesellschaft für Neurologie, 209–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83771-5_41.

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Conference papers on the topic "COMT"

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Lu, Liping, and Jiannong shi. "Association between Creativity and COMT Genotype." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515671.

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Lu, Liping, and Jiannong Shi. "Association between Intelligence and COMT Genotypes in Chinese Healthy Children." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515844.

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Ivanova, Svetlana, Diana Paderina, Anastasiia Boiko, Olga Fedorenko, Ivan Pozhidaev, Vladimir Tigunsev, Elena Kornetova, Nikolay Bokhan, Bob Wilffert, and Anton Loonen. "COMT gene polymorphism and antipsychotic- induced hyperprolactinemia in schizophrenia patients." In 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, 2020. http://dx.doi.org/10.1109/csgb51356.2020.9214668.

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Surendran, R., and T. Tamilvizhi. "Cloud of medical things (CoMT) based smart healthcare framework for resource allocation." In 3rd Smart Cities Symposium (SCS 2020). Institution of Engineering and Technology, 2021. http://dx.doi.org/10.1049/icp.2021.0855.

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Dong, Daiyun. "COMT, DRD1, DRD2, DRD4: Genetic evidence for the dopamine hypothesis in schizophrenia." In 7TH INTERNATIONAL CONFERENCE ON MATHEMATICS: PURE, APPLIED AND COMPUTATION: Mathematics of Quantum Computing. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0112965.

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Valenzuela, Brayan, Isail Salazar, and Fabio Martinez. "Lagrangian center of mass (CoMt) magnification to stand out main parkinsonian gait events." In 2019 XXII Symposium on Image, Signal Processing and Artificial Vision (STSIVA). IEEE, 2019. http://dx.doi.org/10.1109/stsiva.2019.8730254.

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Nasr, Ali, and John McPhee. "Control-Oriented Muscle Torque (COMT) Model for EMG-Based Control of Assistive Robots." In The 7th International Conference of Control, Dynamic Systems, and Robotics. Avestia Publishing, 2020. http://dx.doi.org/10.11159/cdsr20.144.

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Smolnikova, Marina, and Sergey Tereshchenko. "Genetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents." In 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, 2020. http://dx.doi.org/10.1109/csgb51356.2020.9214680.

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Blagosklonov, O., J. C. Cardot, C. Roux, T. Gharbi, and P. Picart. "The First Experience of a Dedicated Biomedical Education Unit at the University of Franche-Comt&#233;." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616419.

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Li, J., S. F. Jiang, H. Y. Chen, K. Liu, F. L. Niu, and G. Z. Zhang. "A case-control study on 5 kinds of heavy metal, COMT genetic polymorphisms and risk of breast cancer." In International Conference on Environmental Science and Biological Engineering. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/esbe140651.

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Reports on the topic "COMT"

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Balut, Stephen J. Cost in Cost-Effectiveness. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada407699.

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Ferreira, Douglas, and Claudia Costa. Impacto das condições atmosféricas em atividades da Vale ao longo do corredor Norte. ITV, 2020. http://dx.doi.org/10.29223/prod.tec.itv.ds.2020.38.ferreira.

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A cadeia mineral da Vale ao longo do Corredor Norte, localizado no leste da Amazônia, entre os estados do Pará e Maranhão, ocorre a céu aberto e está frequentemente exposta aos fenômenos atmosféricos indutores de mau tempo, como tempestades, incidência de raios, rajadas de vento, etc. Neste sentido, o presente relatório técnico teve como objetivo evidenciar os impactos das condições atmosféricas ao longo da cadeia mineral, com ênfase nos sítios de Carajás e no Terminal Marítimo Ponta da Madeira (TMPM). A abordagem foi conduzida com base na análise de dados meteorológicos e na percepção de empregados da Vale alocados em ambos os sítios. Os resultados demonstraram que o Corredor Norte da Vale é influenciado por sistemas atmosféricos, que atuam em diferentes períodos do ano conforme a região. A climatologia regional da precipitação demonstrou uma sazonalidade marcante, com períodos chuvosos e secos distintos entre Carajás e o TMPM, característica que é considerada no planejamento logístico e operacional da Vale, como constatado nas entrevistas com alguns empregados da Vale. Os resultados capturados em tais entrevistas evidenciaram que as condições atmosféricas estão diretamente associadas a atividades da Vale, como citado por gerências operacionais e manutenção, por exemplo. Além disso, a percepção do entrevistado da gerência de segurança ocupacional, monitorar e prever a eventos meteorológicos vai muito além da questão da produção, mas principalmente no ato de salvaguardar a vida dos empregados da Vale, bem como das comunidades que residem em áreas de mineração. Particularmente no TMPM, a criação de um Comitê de Umidade para a mitigação dos impactos atmosféricos na cadeia mineral, como foco em ações para os próximos períodos chuvosos, reforça que a Vale tem dedicado atenção na redução as incertezas em relação aos eventos meteorológicos danosos às suas operações, bem como tem investido em tecnologias aplicadas ao monitoramento e previsão de tempo. Os resultados encontrados no presente relatório técnico corroboram com o uso de tecnologias em meteorologia, capazes de diagnosticar o estado momentâneo da atmosfera, de modo que as informações relevantes sejam disponibilizadas no formato de alertas aos usuários interessados.
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Fonseca, William D'Andrea. Introdução ao LaTeX e como iniciar um novo projeto no Overleaf: Trabalho com acabamento profissional (diretamente em PDF). William D'Andrea Fonseca, July 2020. http://dx.doi.org/10.55753/aev.v35e52.40.

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Este artigo apresenta informações básicas do que é o LaTeX, bem como informações de funcionamento e o seu propósito. Motivações para usar e como começar um texto (ou trabalho) nesse sistema são também aclaradas. A plataforma online de edição Overleaf é utilizada, trazendo informações de como iniciar um novo projeto e de como usar os arquivos modelo da Revista Acústica e Vibrações.
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Fachinelli, Ana Cristina, Cíntia Paese Giacomello, Bianca Libardi, Catiane Borsatto, Rafael de Lucena Perini, Suane de Atayde Moschen, and Suélen Bebber. Perfil socioeconômico de Caxias do Sul 2021. UCS - Universidade de Caxias do Sul, June 2022. http://dx.doi.org/10.18226/9786500465075.

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Ao produzir este perfil socioeconômico, analisamos a estrutura social e econômica de Caxias do Sul. Destacamos em todo o material as qualidades de Caxias do Sul, apresentando-o como um ambiente favorável para viver com qualidade de vida e desenvolver negócios. Esta publicação consolida diversas informações sobre Caxias do Sul e serve como referência para apoiar decisões de investimento, formulação de políticas, informar os visitantes e o público sobre os ativos e passivos do município, e seus fatos socioeconômicos. A revista Perfil Socioeconômico de Caxias do Sul tem como objetivo apresentar à comunidade os aspectos que mais se destacam na cidade. Os eixos temáticos foram definidos e, com base neles, são apresentados os dados primários obtidos de fontes oficiais. Séries históricas e comparações com dados estatais e nacionais nos permitem posicionar Caxias do Sul em relação a outros lugares. A responsabilidade pela coleta e análise dos dados cabe à equipe da Citylivinglab, um grupo de pesquisa do Programa de Pós-Graduação em Administração da Universidade de Caxias do Sul. A publicação é baseada em dados secundários, e todas as fontes são citadas em toda a revista. Sempre utilizamos os dados mais recentes disponíveis.
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Milligan, M., E. Ela, B. M. Hodge, B. Kirby, D. Lew, C. Clark, J. DeCesaro, and K. Lynn. Cost-Causation and Integration Cost Analysis for Variable Generation. Office of Scientific and Technical Information (OSTI), June 2011. http://dx.doi.org/10.2172/1018105.

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Granderson, Jessica, Samir Touzani, Eliot Crowe, Samuel Fernandes, Shankar Earni, and Kaiyu Sun. Realizing High-Accuracy Low-Cost Measurement and Verification for Deep Cost Savings (BPA Cost Share CRADA). Office of Scientific and Technical Information (OSTI), February 2020. http://dx.doi.org/10.2172/1599182.

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Chrispin, Thyeres Teixeira Bueno, Claudia Cristina Takano Novoa, and Marair Gracio Ferreira Sartori. Dilatadores vaginais produzidos por impressora 3d para uso em Ginecologia. Universidade Federal de São Paulo., 2022. http://dx.doi.org/10.34024/agits20220002.

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A agenesia vaginal é uma malformação congênita do trato reprodutivo das mulheres causada por uma anomalia na formação dos ductos paramesonéfricos (Müller), que são responsáveis por originar os órgãos genitais internos no sexo feminino. Os dilatadores vaginais têm como objetivo promover a dilatação e conscientização da musculatura do assoalho pélvico em mulheres com alguma disfunção nesta área por meio de tratamento de caráter progressivo. Particularmente entre mulheres com agenesia vaginal, a criação de dilatadores vaginais personalizados à sua própria anatomia, com auxílio de impressão 3D, pode ser uma excelente alternativa terapêutica.
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HARTLEY, D. S. III, and S. L. PACKARD. OOTW COST TOOLS. Office of Scientific and Technical Information (OSTI), September 1998. http://dx.doi.org/10.2172/3095.

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Smith, Larry L. Cost Improvement Analysis. Fort Belvoir, VA: Defense Technical Information Center, June 1986. http://dx.doi.org/10.21236/ada200215.

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Strait, R. S. Cost analysis guidelines. Office of Scientific and Technical Information (OSTI), January 1996. http://dx.doi.org/10.2172/219299.

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