Relevant bibliographies by topics / COMSTAT2

Academic literature on the topic 'COMSTAT2'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "COMSTAT2"

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Verotta, Davide, Janus Haagensen, Alfred M. Spormann, and Katherine Yang. "Mathematical Modeling of Biofilm Structures Using COMSTAT Data." Computational and Mathematical Methods in Medicine 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/7246286.

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Mathematical modeling holds great potential for quantitatively describing biofilm growth in presence or absence of chemical agents used to limit or promote biofilm growth. In this paper, we describe a general mathematical/statistical framework that allows for the characterization of complex data in terms of few parameters and the capability to (i) compare different experiments and exposures to different agents, (ii) test different hypotheses regarding biofilm growth and interaction with different agents, and (iii) simulate arbitrary administrations of agents. The mathematical framework is divided to submodels characterizing biofilm, including new models characterizing live biofilm growth and dead cell accumulation; the interaction with agents inhibiting or stimulating growth; the kinetics of the agents. The statistical framework can take into account measurement and interexperiment variation. We demonstrate the application of (some of) the models using confocal microscopy data obtained using the computer program COMSTAT.
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Streitberg, B., J. Röhmel, W. M. Herrmann, and S. Kubicki. "COMSTAT Rule for Vigilance Classification Based on Spontaneous EEG Activity." Neuropsychobiology 17, no. 1-2 (1987): 105–17. http://dx.doi.org/10.1159/000118347.

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Heydorn, Arne, Alex Toftgaard Nielsen, Morten Hentzer, Claus Sternberg, Michael Givskov, Bjarne Kjær Ersbøll, and Søren Molin. "Quantification of biofilm structures by the novel computer program comstat." Microbiology 146, no. 10 (October 1, 2000): 2395–407. http://dx.doi.org/10.1099/00221287-146-10-2395.

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Moutinho, Luiz. "The Comstrat Model: Development of an Expert System in Strategic Marketing." Journal of General Management 19, no. 1 (September 1993): 32–47. http://dx.doi.org/10.1177/030630709301900103.

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Stapper, Andres Plata, Giri Narasimhan, Dennis E. Ohman, Johnny Barakat, Morten Hentzer, Søren Molin, Arsalan Kharazmi, Niels Høiby, and Kalai Mathee. "Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation." Journal of Medical Microbiology 53, no. 7 (July 1, 2004): 679–90. http://dx.doi.org/10.1099/jmm.0.45539-0.

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Extracellular polymers can facilitate the non-specific attachment of bacteria to surfaces and hold together developing biofilms. This study was undertaken to qualitatively and quantitatively compare the architecture of biofilms produced by Pseudomonas aeruginosa strain PAO1 and its alginate-overproducing (mucA22) and alginate-defective (algD) variants in order to discern the role of alginate in biofilm formation. These strains, PAO1, Alg+ PAOmucA22 and Alg− PAOalgD, tagged with green fluorescent protein, were grown in a continuous flow cell system to characterize the developmental cycles of their biofilm formation using confocal laser scanning microscopy. Biofilm Image Processing (bip) and Community Statistics (comstat) software programs were used to provide quantitative measurements of the two-dimensional biofilm images. All three strains formed distinguishable biofilm architectures, indicating that the production of alginate is not critical for biofilm formation. Observation over a period of 5 days indicated a three-stage development pattern consisting of initiation, establishment and maturation. Furthermore, this study showed that phenotypically distinguishable biofilms can be quantitatively differentiated.
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Ogodescu, Alexandru Simion, Alexandru Attila Morvay, Adriana Balan, Laura Gavrila, Ana Petcu, and Carmen Savin. "Comparative Study on the Effect of Three Disinfection Procedure on the Streptococcus pyogenes Biofilm Formed on Plastic Materials Used in Paedodontics and Orthodontics." Materiale Plastice 54, no. 1 (March 30, 2017): 116–18. http://dx.doi.org/10.37358/mp.17.1.4797.

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Plastic materials are widely used today in Paedodontics and Orthodontics for manufacturing preventive and therapeutic devices. Since these are worn for long times in the oral cavity biofilm forms on the smooth acrylic surfaces of those appliances. The biofilm must be removed not to destroy the oral microbiology. The aim of this study was to research the possibility of removing the microbial biofilm and disinfecting retainers using the photodynamic effect of toluidine blue O, Fotosan System (CMS Dental, Copenhagen, Denmark) in comparison to two products available on the market Corega Denture Cleanser Tablets (GlaxoSmithKline) and the Retainer Brite� Cleaning Tablets (DENTSPLY International Raintree Essix, FL, USA). The plastic material used in this experiment was the cold-cure acrylic Palapress� vario (Heraeus-Kulzer GmbH, Hanau, Germany). Images of the biofilm formed by Streptococcus pyogenes were obtained using a confocal laser scanning m icroscope. The images were analyzed using Comstat 2 software. The results showed that all the three investigated methods had a disinfectant effect. Corega Denture Cleanser Tablets reduced most of the biofilm formed on the plastic substrate.
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Kreth, J., E. Hagerman, K. Tam, J. Merritt, D. T. W. Wong, B. M. Wu, N. V. Myung, W. Shi, and F. Qi. "Quantitative analyses of Streptococcus mutans biofilms with quartz crystal microbalance, microjet impingement and confocal microscopy." Biofilms 1, no. 4 (October 2004): 277–84. http://dx.doi.org/10.1017/s1479050504001516.

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Microbial biofilm formation can be influenced by many physiological and genetic factors. The conventional microtiter plate assay provides useful but limited information about biofilm formation. With the fast expansion of the biofilm research field, there are urgent needs for more informative techniques to quantify the major parameters of a biofilm, such as adhesive strength and total biomass. It would be even more ideal if these measurements could be conducted in a real-time, non-invasive manner. In this study, we used quartz crystal microbalance (QCM) and microjet impingement (MJI) to measure total biomass and adhesive strength, respectively, of S. mutans biofilms formed under different sucrose concentrations. In conjunction with confocal laser scanning microscopy (CLSM) and the COMSTAT software, we show that sucrose concentration affects the biofilm strength, total biomass, and architecture in both qualitative and quantitative manners. Our data correlate well with previous observations about the effect of sucrose on the adherence of S. mutans to the tooth surface, and demonstrate that QCM is a useful tool for studying the kinetics of biofilm formation in real time and that MJI is a sensitive, easy-to-use device to measure the adhesive strength of a biofilm.
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Jamet, Anne, Daniel Euphrasie, Patricia Martin, and Xavier Nassif. "Identification of Genes Involved in Neisseria meningitidis Colonization." Infection and Immunity 81, no. 9 (July 1, 2013): 3375–81. http://dx.doi.org/10.1128/iai.00421-13.

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ABSTRACTNeisseria meningitidisis a worldwide cause of meningitis and septicemia leading at least to 50,000 deaths every year. Nevertheless,N. meningitidisis also a commensal bacterium that asymptomatically colonizes the epithelial cells of the nasopharynx of 10 to 30% of healthy individuals. Occasionally,N. meningitidiscrosses the nasopharyngeal barrier and enters the bloodstream. During bacteremia,N. meningitidismay adhere to endothelial cells of brain vessels and invade meninges. To identify the genes required for meningococcal host colonization, we screened a signature-tagged transposon mutagenesis library using an innovativein vitrocolonization model in order to identify mutants displaying decreased capacity to colonize human epithelial cells. Approximately 1,600 defined insertion mutants of invasive serogroup C strain NEM8013 were screened. Candidate mutants were tested individually for quantification of bacterial biomass with confocal microscope and COMSTAT software. Five mutants were demonstrated to exhibit significantly decreased colonization ability. The identified genes, includingnarPandestD, appeared to be involved in adaptation to hypoxic conditions and stress resistance. Interestingly, the genesfadD1,nnrS, andNMV_2034(encoding a putative thioredoxin), prior to this study, had not been shown to be involved in colonization. Therefore, we provide here insights into the meningococcal functions necessary for the bacterium to adapt to growth on host cells.
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Heydorn, Arne, Bjarne Ersbøll, Junichi Kato, Morten Hentzer, Matthew R. Parsek, Tim Tolker-Nielsen, Michael Givskov, and Søren Molin. "Statistical Analysis of Pseudomonas aeruginosa Biofilm Development: Impact of Mutations in Genes Involved in Twitching Motility, Cell-to-Cell Signaling, and Stationary-Phase Sigma Factor Expression." Applied and Environmental Microbiology 68, no. 4 (April 2002): 2008–17. http://dx.doi.org/10.1128/aem.68.4.2008-2017.2002.

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ABSTRACT Four strains of Pseudomonas aeruginosa (wild type, ΔpilHIJK mutant, lasI mutant, and rpoS mutant) were genetically tagged with the green fluorescent protein, and the development of flow chamber-grown biofilms by each of them was investigated by confocal laser scanning microscopy. The structural developments of the biofilms were quantified by the computer program COMSTAT (A. Heydorn, A. T. Nielsen, M. Hentzer, C. Sternberg, M. Givskov, B. K. Ersbøll, and S. Molin, Microbiology 146:2395-2407, 2000). Two structural key variables, average thickness and roughness, formed the basis for an analysis of variance model comprising the four P. aeruginosa strains, five time points (55, 98, 146, 242, and 314 h), and three independent rounds of biofilm experiments. The results showed that the wild type, the ΔpilHIJK mutant, and the rpoS mutant display conspicuously different types of temporal biofilm development, whereas the lasI mutant was indistinguishable from the wild type at all time points. The wild type and the lasI mutant formed uniform, densely packed biofilms. The rpoS mutant formed densely packed biofilms that were significantly thicker than those of the wild type, whereas the ΔpilHIJK mutant formed distinct microcolonies that were regularly spaced and almost uniform in size. The results are discussed in relation to the current model of P. aeruginosa biofilm development.
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Gong, Sheng Zhao, Xiao Xi Tai, and Yun Er Yang. "Inhibitory Kinetics of Isooctyl 4-Hydroxy-3-Methoxycinnamate on Tyrosinase-Catalyzing Reaction." Advanced Materials Research 634-638 (January 2013): 655–58. http://dx.doi.org/10.4028/www.scientific.net/amr.634-638.655.

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The inhibitory kinetics of isooctyl 4-hydroxy-3-methoxycinnamate on the activity of monophenolase and diphenolase contained in tyrosinase was studied by enzymological kinetic method with Na2HPO4-NaH2PO4 buffer solution (pH=6.8) at 30 °C. Isooctyl 4-hydroxy-3-methoxycinnamate was found to inhibit the monophenolase and diphenolase activity of tyrosinase well. The isooctyl 4-hydroxy-3-methoxycinnamate concentrations leading to 50 % inhibitory rate (IC50) were 0.24 mmol/L for monophenolase and 0.45 mmol/L for diphenolase, much less than that of arbutin (IC50 =5.3 mmol/L for diphenolase activity). Isooctyl 4-hydroxy-3-methoxycinnamate could extend the lag time of tyrosinase for oxidation of L-tyrosine, 0.4 mmol/L of isooctyl 4-hydroxy-3-methoxycinnamate resulted in the extension of lag time from 1.1 min to 3.6 min. The inhibition kinetics of isooctyl 4-hydroxy-3-methoxycinnamate analyzed by Lineweaver-Burk plots demonstrated a competitive inhibitor for the oxidation of L-DOPA, the apparent Michaelis comstant, Km, and the inhibition constant for inhibitor binding with enzyme, KI, were determined to be 0.45 mmol/L and 0.20 mmol/L respectively.
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Dissertations / Theses on the topic "COMSTAT2"

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Unter, Kevin A. "The New Orleans Police Department: Melding Police and Policy to Dramatically Reduce Crime in the City of New Orleans." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/599.

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In 1996, the New Orleans Police Department implemented the COMSTAT management and accountability style of policing. Within three years of that implementation, murder was cut by over fifty percent and violent crime fell by nearly the same amount; overall crime was cut by over one-third compared to just three years ago. This dissertation seeks to explore the reasons crime declined so rapidly in New Orleans post-COMSTAT implementation, compared to crime in the rest of the country. Drawing on political and criminological theories of policing as well as sociological theories, variables unique to each set of theories were identified and tested alone and against competing explanations. Utilizing higher-ordered time series methodology, two analyses were conducted. The first utilized interrupted time-series analysis to identify the nature of COMSTAT's impact on New Orleans' crime trends, measured as changes in the current quarter compared to the same quarter of the preceding year. The results show that while COMSTAT had a significant impact on the crime trends, the effects were short-lived. The second analysis utilized traditional time series methodology to examine the impacts of the individual variables on the overall crime trends. The results show that while policing variables and sociological variables have little effect on the overall crime trends both individually and when tested together, the findings indicate policing variables play a larger role than sociological variables when included together. As another independent test of the effects of crime, public opinion data obtained via the University of New Orleans' Survey Research Center from 1986-2004 show that the public was very positive towards the NOPD's efforts in dramatically reducing crime and fear of crime in New Orleans during this period. The overall results for policy makers then indicates that reductions in crime resonate positively with city residents and future policy decisions should be made with that goal in mind.
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Singhal, Deepti. "Bacterial & fungal biofilms in chronic rhinosinusitis." Thesis, 2011. http://hdl.handle.net/2440/72282.

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Chronic Rhinosinusitis (CRS) is a recalcitrant disease, characterized by headache, nasal discharge / blockage, which substantially impairs daily functioning and negatively affect quality of life. Endoscopic Sinus Surgery (ESS) is an important treatment option for CRS, but has variable success rates. Biofilms are well organised heterogeneous communities of microbes embedded in a mosaic of extracellular matrix, adherent to biotic / abiotic surfaces. As they are resistant to host defences and medical treatments, they have been touted as possible pathogenic factors in CRS, which may perpetuate the recurrent and recalcitrant character of the disease and negatively affect treatment outcomes. This thesis encompasses research undertaken to enhance our understanding about the effect that presence and types of biofilms have on the clinical profile and treatment outcomes of patients suffering with chronic rhinosinusitis. An in-vitro model of fungal biofilms and a potential tool to assay in-vivo mucosal biofilms on sinonasal tissues has also been described. Chapter 1 of the thesis comprehensively reviews the scientific literature pertaining to biofilms and CRS, and exhaustively evaluates the evidence present in relation to bacterial and fungal biofilms in CRS. Chapter 2 describes a study to investigate the effect of biofilms on outcomes following ESS in CRS patients using internationally accepted standardised symptom scores, quality of life measures and endoscopy scores to assess the disease. It showed that patients with biofilms presented with more severe disease before surgery, and after surgery had persistent symptoms, ongoing mucosal inflammation and infections necessitating extra post-operative visits and multiple antibiotic treatments. This study thus strengthened the evidence for the role that biofilms may play in recalcitrant CRS. Chapter 3 describes a further subgroup analysis of the above patients in whom the specific organisms forming the biofilms were identified and how patients with specific biofilm types progressed after surgery was studied. Patients with polymicrobial biofilms suffered more severe disease and had worse post-surgery mucosal outcomes requiring more post–operative visits. S.aureus biofilms played a dominant role in negatively affecting outcomes of ESS with persisting post-operative symptoms, ongoing mucosal inflammation and infections. Chapter 4 describes an in-vitro model characterizing A. fumigatus biofilm formation on primary human sinonasal epithelium cultures under different growth conditions. 3-dimensional biofilm structures with parallel-packed and cross-linked hyphae, channels/passages, extracellular matrix (ECM) encasing the hyphae, were formed. Biofilms formed under flow conditions displayed more robust and faster growth kinetics as compared to those under static conditions, with extensive ECM production. Chapter 5 investigates application of an analysis program ‘COMSTAT 2’ for assaying & quantitatively describing the 3-dimensional in-vivo biofilm structures observed via confocal scanning microscopy on sino-nasal mucosal samples. This can be used for temporal analysis of biofilm development, comparison of different types of biofilms formed under controlled conditions, analysis of influence of varying environmental factors on biofilms and the efficacy of different antibiofilm treatments. Chapter 6 summarises and discusses the salient features of the studies included in this thesis which has attempted to characterize fungal and bacterial biofilms and the impact they may have in CRS patients.
Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2011
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Books on the topic "COMSTAT2"

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Ippolito, Donna. Comstar. Fasa, 1992.

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Fasa and FASA Corporation. Comstar (Fasa). FASA Corp., 1999.

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Book chapters on the topic "COMSTAT2"

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Whalen, David J. "Domsats (COMSTAR and SBS)." In The Rise and Fall of COMSAT, 144–71. London: Palgrave Macmillan UK, 2014. http://dx.doi.org/10.1057/9781137396938_8.

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Moutinho, Luiz, Bruce Curry, and Fiona Davies. "The Comstrat Model: Development of an Expert System in Strategic Marketing." In Proceedings of the 1992 Academy of Marketing Science (AMS) Annual Conference, 498–502. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-13248-8_101.

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Steinhöfel, Jens, Frauke Anders, Hermann Köhler, Dominik Kalisch, and Reinhard König. "Computer-Based Methods for a Socially Sustainable Urban and Regional Planning - CoMStaR." In Computational Science and Its Applications – ICCSA 2010, 152–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12156-2_12.

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"46 Comstrat-Analyse (Competitive Strategy Analysis)." In Die wichtigsten Strategietools für Manager, edited by Michael Hirt, 158–61. Vahlen, 2014. http://dx.doi.org/10.15358/9783800648474-158.

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Conference papers on the topic "COMSTAT2"

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Hoeing, Matthew, Prithviraj Dasgupta, Plamen Petrov, and Stephen O'Hara. "Auction-based multi-robot task allocation in COMSTAR." In the 6th international joint conference. New York, New York, USA: ACM Press, 2007. http://dx.doi.org/10.1145/1329125.1329462.

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Reports on the topic "COMSTAT2"

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Harrer, B. J., M. P. Hattrup, J. E. Dase, and A. K. Nicholls. Analysis of organizational options for the uranium enrichment enterprise in relation to asset divesture. [BPA; TVA; SYNFUELS; CONRAIL; British TELECOM; COMSTAT]. Office of Scientific and Technical Information (OSTI), August 1986. http://dx.doi.org/10.2172/5262902.

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