Academic literature on the topic 'Comprimés gastrorésistants'
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Dissertations / Theses on the topic "Comprimés gastrorésistants":
Dagoneau, Hélène. "Enrobage gastrorésistant des comprimés en milieu aqueux : influence sur la cinétique de libération du principe actif." Paris 5, 1989. http://www.theses.fr/1989PA05P214.
Hauser, Aude. "Les gélules gastrorésistantes." Paris 5, 1996. http://www.theses.fr/1996PA05P105.
Durand, Bénédicte. "Enrobage gastrorésistant des comprimés : étude de l'influence des charges sur les propriétés structurales des films isolés." Paris 5, 1988. http://www.theses.fr/1988PA05P280.
Strich, Samuel. "Oral drug delivery systems based on polysaccharides for colon targeting." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS081.
10 million people worldwide, over 1.5 million in North America and 2 million in Europe. Those are the numbers of people affected by inflammatory bowel disease (IBD) in each region quoted, respectively. Including both Crohn's disease (CD) and ulcerative colitis (UC), inflammatory bowel disease has emerged as a public health challenge worldwide in the past decades. Often diagnosed between 15 and 35 years old, IBD are characterized by moderate to severe symptoms, and have in common relapsing-remitting cycles of mucosal inflammation.To date, there is no cure for IBD. Defined as colon targeting, targeted drug delivery systems is a way to get selective and efficient delivery of pharmacologically active compounds to the predetermined targeted region in therapeutic concentrations along with minimizing side effects of the drug. Current strategies for colon targeting rely on : *) prodrugs, **) pH-dependant systems, ***) time-dependant systems, ****) microbially triggered systems.Of all approaches, microbiota sensitive systems are currently known as the best ones for colonic drug delivery. It is also possible to combine several complementary approaches (pH- and microbiota sensitive) to significantely favor localized drug release.Our project aimed to develop 5 mm mini-tablets for colon targeting. First, a comparison of different film coatings was made to highlight the most interesting drug release profiles. Then, an innovative formulation, combining synthetic and natural polymers as well as polysaccharides, was evaluated. Different blend ratios were selected as well for films as for coated mini-tablets. In vitro drug release was carried out in simulated digestive fluids for a 32 h duration, including:- 0.1 N HCl or simulated gastric fluid (2 h)- PBS 6.8 or simulated intestinal fluid (6 h)- Colonic simulated medium with and without patients' faeces (24 h).Colonic simulated medium inoculated with patients' faeces allowed for working closer to pathophysiological conditions. Relevant results were obtained and paved the way for a promising monolayer technology. None or negligible drug release occurred up to 8 h, in the upper GIT. Also, drug could be totally protected in the lower gastrointestinal tract.Ethylcellulose, as a thermoplastic polymer, prevented from premature dissolution.Shellac, as a natural resin, provided pH-dependant properties.The adjunction of a polysaccharide acted as a substrate of microbiota.Interestingly, colonic release profiles could be optimized depending on the amount of polysaccharide added into the system
Raffin, Fernanda Nervo. "Investigations physicochimiques de la perméabilité aux ions hydrogènes de films isolés d'acétophtalate de cellulose. Interaction des facteurs de formulation. Application à l'enrobage gastrorésistant de comprimés d'enzyme acido labile." Montpellier 1, 1995. http://www.theses.fr/1995MON13501.