Journal articles on the topic 'Compound action potential'

To see the other types of publications on this topic, follow the link: Compound action potential.

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Compound action potential.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Molin, Carl Johan, and Anna R. Punga. "Compound Motor Action Potential." Journal of Clinical Neurophysiology 33, no. 4 (August 2016): 340–45. http://dx.doi.org/10.1097/wnp.0000000000000252.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Carvalho, Mamede de. "Compound Muscle Action Potential: Pro." Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 3, sup1 (September 2002): S103—S104. http://dx.doi.org/10.1080/146608202320374453.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Sonoo, Masahiro. "Far‐field potentials in the compound muscle action potential." Muscle & Nerve 61, no. 3 (November 20, 2019): 271–79. http://dx.doi.org/10.1002/mus.26743.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Dengler, Reinhard. "Quantitative Compound Muscle Action Potential: Con." Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 3, sup1 (September 2002): S105—S107. http://dx.doi.org/10.1080/146608202320374462.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Petajan, Jack H. "Quantitative Compound Muscle Action Potential: Summary." Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 3, sup1 (September 2002): S109—S110. http://dx.doi.org/10.1080/146608202320374471.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Glassman, E. Katelyn, and Michelle L. Hughes. "Determining Electrically Evoked Compound Action Potential Thresholds." Ear and Hearing 34, no. 1 (2013): 96–109. http://dx.doi.org/10.1097/aud.0b013e3182650abd.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Briaire, Jeroen J., and Johan H. M. Frijns. "Unraveling the electrically evoked compound action potential." Hearing Research 205, no. 1-2 (July 2005): 143–56. http://dx.doi.org/10.1016/j.heares.2005.03.020.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Chatterjee, Monita, and Robert L. Smith. "Physiological overshoot and the compound action potential." Hearing Research 69, no. 1-2 (September 1993): 45–54. http://dx.doi.org/10.1016/0378-5955(93)90092-f.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Malessy, Martijn J. A., Willem Pondaag, and J. Gert van Dijk. "ELECTROMYOGRAPHY, NERVE ACTION POTENTIAL, AND COMPOUND MOTOR ACTION POTENTIALS IN OBSTETRIC BRACHIAL PLEXUS LESIONS." Neurosurgery 65, suppl_4 (October 1, 2009): A153—A159. http://dx.doi.org/10.1227/01.neu.0000338429.66249.7d.

Full text
Abstract:
Abstract OBJECTIVE Obstetric brachial plexus lesions (OBPLs) are caused by traction to the brachial plexus during labor. Typically, in these lesions, the nerves are usually not completely ruptured but form a “neuroma-in-continuity.” Even in the most severe OBPL lesions, at least some axons will pass through this neuroma-in-continuity and reach the tubes distal to the lesion site. These axons may be particularly prone to abnormal branching and misrouting, which may explain the typical feature of co-contraction. An additional factor that may reduce functional regeneration is that improper central motor programming may occur. Surgery should be restricted to severe cases in which spontaneous restoration of function will not occur, i.e., in neurotmesis or root avulsions. A major problem is how to predict whether function will be best after spontaneous nerve outgrowth or after nerve reconstructive surgery. When a decision has been made to perform an early surgical exploration, what to do with the neuroma-in-continuity can be a problem. The intraoperative appraisal is difficult and depends on experience, but even in experienced hands, misjudgment can be made. METHODS We performed an observational study to assess whether early electromyography (at the age of 1 month) is able to predict severe lesions. Additionally, the value of intraoperative nerve action potential and compound motor action potentials was investigated. RESULTS Severe cases of OBPL can be identified at 1 month of age on the basis of clinical findings and needle electromyography of the biceps. This outcome needs independent validation, which is currently in progress. Nerve action potential and compound motor action potential recordings show statistically significant differences on the group level between avulsion, neurotmesis, axonotmesis, and normal. For the individual patient, a clinically useful cutoff point could not be found. Intraoperative nerve action potential and compound motor action potential recordings do not add to the decision making during surgery. CONCLUSION The absence of a “gold standard” for the assessment of the severity of the OBPL lesion makes prognostic studies of OBPL complex. The currently available assessment strategies used to obtain the best possible solutions are discussed.
APA, Harvard, Vancouver, ISO, and other styles
10

Pollak, V. A., and Q. X. Wan. "The Z-transform of the compound action potential." IEEE Engineering in Medicine and Biology Magazine 16, no. 3 (May 1997): 80–86. http://dx.doi.org/10.1109/51.585522.

Full text
APA, Harvard, Vancouver, ISO, and other styles
11

Kincaid, John C. "The compound muscle action potential and its shape." Muscle & Nerve 22, no. 1 (January 1999): 4–5. http://dx.doi.org/10.1002/(sici)1097-4598(199901)22:1<4::aid-mus3>3.0.co;2-b.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Barroso, Fabio A., and Macarena I. de la Fuente. "Compound muscle action potential temporal dispersion during hypokalemia." Muscle & Nerve 40, no. 4 (October 2009): 662–63. http://dx.doi.org/10.1002/mus.21390.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Abbas, P. J., C. P. Etler, C. J. Brown, T. Van Voorst, L. Zubrod, and S. Dunn. "Electrically evoked compound action potential using Nucleus RP8." International Congress Series 1273 (November 2004): 80–83. http://dx.doi.org/10.1016/j.ics.2004.08.099.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Barboza, Joice Nascimento, Carlos da Silva Maia Bezerra Filho, Renan Oliveira Silva, Jand Venes R. Medeiros, and Damião Pergentino de Sousa. "An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol." Oxidative Medicine and Cellular Longevity 2018 (October 22, 2018): 1–9. http://dx.doi.org/10.1155/2018/3957262.

Full text
Abstract:
The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against several diseases, such as those associated with inflammatory processes, which are commonly related to oxidative stress. Many of these compounds have an appreciable inhibitory effect on oxidative stress and inflammatory response, and may contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, action on the redox status, and applications in the food and pharmaceutical industry. Considering the importance of this compound, the present review discusses its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases.
APA, Harvard, Vancouver, ISO, and other styles
15

Rybak, Leonard P., Craig Whitworth, and Vernedra Scott. "Development of endocochlear potential and compound action potential in the rat." Hearing Research 59, no. 2 (May 1992): 189–94. http://dx.doi.org/10.1016/0378-5955(92)90115-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

CEHRELI, Z., M. ALIONUR, F. TASMAN, A. GUMRUKCUOGLU, and H. ARTUNER. "Effects of Current and Potential Dental Etchants on Nerve Compound Action Potentials." Journal of Endodontics 28, no. 3 (March 2002): 149–51. http://dx.doi.org/10.1097/00004770-200203000-00001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

Sonoo, Masahiro, Katsumi Kurokawa, Mana Higashihara, Hiroko Kurono, Keiichi Hokkoku, Yuki Hatanaka, and Teruo Shimizu. "Origin of far-field potentials in the ulnar compound muscle action potential." Muscle & Nerve 43, no. 5 (April 11, 2011): 671–78. http://dx.doi.org/10.1002/mus.21931.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Parker, John L., Nastaran H. Shariati, and Dean M. Karantonis. "Electrically evoked compound action potential recording in peripheral nerves." Bioelectronics in Medicine 1, no. 1 (January 2018): 71–83. http://dx.doi.org/10.2217/bem-2017-0005.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Earl, Brian R., and Mark E. Chertoff. "Predicting Auditory Nerve Survival Using the Compound Action Potential." Ear and Hearing 31, no. 1 (February 2010): 7–21. http://dx.doi.org/10.1097/aud.0b013e3181ba748c.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Abbas, Ahmed, and Rajdeep Jain. "Repetitive compound muscle action potential: a characteristic diagnostic clue." Practical Neurology 19, no. 1 (September 5, 2018): 77–79. http://dx.doi.org/10.1136/practneurol-2018-002044.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

Nockolds, C. L., G. L. Hosker, and E. S. Kiff. "Compound muscle action potential of the external anal sphincter." Colorectal Disease 15, no. 10 (October 2013): 1289–94. http://dx.doi.org/10.1111/codi.12315.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Kramer, Christopher L., Andrea J. Boon, C. Michel Harper, and Brent P. Goodman. "Compound muscle action potential duration in critical illness neuromyopathy." Muscle & Nerve 57, no. 3 (July 5, 2017): 395–400. http://dx.doi.org/10.1002/mus.25732.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Brown, M. C. "The antidromic compound action potential of the auditory nerve." Journal of Neurophysiology 71, no. 5 (May 1, 1994): 1826–34. http://dx.doi.org/10.1152/jn.1994.71.5.1826.

Full text
Abstract:
1. The antidromic compound action potential (ACAP) of the auditory nerve was evoked by shocks to the auditory nerve root and recorded at the round window of the cochlea in anesthetized guinea pigs. The goal of this study was to determine the characteristics of the ACAP and compare these characteristics with those of the orthodromic, sound-evoked compound action potential (CAP). 2. The ACAP consists of an initial complex of a positive peak (p1) followed by a negative peak (n1). In contrast, the CAP consists of a negative peak (N1) followed by a positive peak (P1). These differences in waveform are likely due to the differences in conduction direction, antidromic for the ACAP vs. orthodromic for the CAP. 3. After the initial complex, the ACAP has a second complex of peaks (p2, n2) at a latency of approximately 1 ms; this complex is much smaller in amplitude than the initial complex (p1, n1). It is likely that the initial ACAP complex reflects firing of auditory-nerve fibers whereas the second complex reflects firing of neurons further centrally, perhaps in the cochlear nucleus, that are activated by orthodromic firing of auditory-nerve fibers. 4. Experiments with shock pairs are consistent with the idea that for auditory nerve fibers, the absolute refractory period is < 0.5 ms, and the relative refractory period is between 0.5 and at least 5 ms. 5. Experiments with click-shock pairs indicate that a shock interferes with the response to a click when the click and shock are given at about the same time.(ABSTRACT TRUNCATED AT 250 WORDS)
APA, Harvard, Vancouver, ISO, and other styles
24

Stecker, Mark, Kelly Baylor, and Yiumo Chan. "Acute nerve compression and the compound muscle action potential." Journal of Brachial Plexus and Peripheral Nerve Injury 03, no. 01 (September 17, 2014): e5-e13. http://dx.doi.org/10.1186/1749-7221-3-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Stecker, Mark, Kelly Baylor, Jacob Wolfe, and Matthew Stevenson. "Acute nerve stretch and the compound motor action potential." Journal of Brachial Plexus and Peripheral Nerve Injury 06, no. 01 (September 23, 2014): e11-e22. http://dx.doi.org/10.1186/1749-7221-6-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
26

Bromberg, M. B., and T. Spiegelberg. "Active electrode placement and compound muscle action potential amplitude." Electroencephalography and Clinical Neurophysiology 98, no. 3 (March 1996): P32. http://dx.doi.org/10.1016/0013-4694(96)80371-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Rajabally, Yusuf A., Darren Martin-Lamb, and Guillaume Nicolas. "Compound muscle action potential amplitude and distal potential duration in axonal neuropathy." Muscle & Nerve 49, no. 1 (December 5, 2013): 146–47. http://dx.doi.org/10.1002/mus.24065.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Lang, H., B. A. Schulte, and R. A. Schmiedt. "Endocochlear potentials and compound action potential recovery: functions in the C57BL/6J mouse." Hearing Research 172, no. 1-2 (October 2002): 118–26. http://dx.doi.org/10.1016/s0378-5955(02)00552-x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Kwon, Hee Kyu, Lina Kim, and Yoon Keun Park. "Compound Nerve Action Potential of Common Peroneal Nerve and Sural Nerve Action Potential in Common Peroneal Neuropathy." Journal of Korean Medical Science 23, no. 1 (2008): 117. http://dx.doi.org/10.3346/jkms.2008.23.1.117.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Jang, Gwanghoon, Sungjoon Park, Sanghoon Lee, Sunkyu Kim, Sejeong Park, and Jaewoo Kang. "Predicting mechanism of action of novel compounds using compound structure and transcriptomic signature coembedding." Bioinformatics 37, Supplement_1 (July 1, 2021): i376—i382. http://dx.doi.org/10.1093/bioinformatics/btab275.

Full text
Abstract:
Abstract Motivation Identifying mechanism of actions (MoA) of novel compounds is crucial in drug discovery. Careful understanding of MoA can avoid potential side effects of drug candidates. Efforts have been made to identify MoA using the transcriptomic signatures induced by compounds. However, these approaches fail to reveal MoAs in the absence of actual compound signatures. Results We present MoAble, which predicts MoAs without requiring compound signatures. We train a deep learning-based coembedding model to map compound signatures and compound structure into the same embedding space. The model generates low-dimensional compound signature representation from the compound structures. To predict MoAs, pathway enrichment analysis is performed based on the connectivity between embedding vectors of compounds and those of genetic perturbation. Results show that MoAble is comparable to the methods that use actual compound signatures. We demonstrate that MoAble can be used to reveal MoAs of novel compounds without measuring compound signatures with the same prediction accuracy as that with measuring them. Availability and implementation MoAble is available at https://github.com/dmis-lab/moable Supplementary information Supplementary data are available at Bioinformatics online.
APA, Harvard, Vancouver, ISO, and other styles
31

Vadivelan Ramachandran, Bhargav Bhongiri, Raju Bairi, and Raman Suresh Kumar. "Potential Health Benefit Of Isoflavones." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 21, 2020): 2463–67. http://dx.doi.org/10.26452/ijrps.v11ispl4.4499.

Full text
Abstract:
Isoflavones are bioactive compounds and structurally related to 17-β-estradiol having mild estrogenic character also known phytoestrogen. These are available in more quantities in vegetables like green beans, soybeans, mung beans. In grains, they are available for the most part as glycosides, which are absorbed very poorly. It can behave as estrogen agonists or antagonist, by depending on the estrogenic level of endocrine, yet the action of isoflavones are complex because of numerous factors, for example, compound structures and mode of action. Though foods rich in isoflavones have become a centre of interest because of their beneficial effect on many health issues. In view of the appraisal of these illnesses by the action of isoflavones, it was fulfilled that the ability of isoflavones in the anticipation and management of different ailments generally results from their phytoestrogen antioxidant action. Isoflavones were called to as mysterious biological compounds that characteristic to forestall many major health issues. Intake of soy product has been connected to a decrease in rate or seriousness of long term illness, for example, heart disorder, breast and prostate malignancies, menopausal symptoms, bone disorder, so forth. This review discussed an overview of its health benefit on different human diseases.
APA, Harvard, Vancouver, ISO, and other styles
32

Kawano, Osamu, Keiichiro Shiba, Takayoshi Ueta, Kenzo Shirasawa, Hideki Ohta, Eiji Mori, Shun-ichi Rikimaru, et al. "Study of Lower Extremity Myotomes by Compound Muscle Action Potential." Orthopedics & Traumatology 45, no. 4 (1996): 1255–58. http://dx.doi.org/10.5035/nishiseisai.45.1255.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Hey, Matthias, Joachim Müller-Deile, Horst Hessel, and Matthijs Killian. "Facilitation and refractoriness of the electrically evoked compound action potential." Hearing Research 355 (November 2017): 14–22. http://dx.doi.org/10.1016/j.heares.2017.09.001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Murnane, Owen D., Beth A. Prieve, and Evan M. Relkin. "Recovery of the human compound action potential following prior stimulation." Hearing Research 124, no. 1-2 (October 1998): 182–89. http://dx.doi.org/10.1016/s0378-5955(98)00136-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
35

Bhatt, Neel K., Wee Tin K. Kao, and Randal C. Paniello. "Compound Motor Action Potential Measures Acute Changes in Laryngeal Innervation." Annals of Otology, Rhinology & Laryngology 127, no. 10 (July 15, 2018): 661–66. http://dx.doi.org/10.1177/0003489418784973.

Full text
Abstract:
Objective: Vocal fold paralysis is caused by injury to the recurrent laryngeal nerve (RLN). Current clinical measures of laryngeal innervation are often nonquantitative. Compound motor action potentials (CMAP) measure motor innervation. The goal of this study was to determine whether CMAP can quantify laryngeal innervation following acute nerve injury. Study Design: Animal study. Methods: Twelve canine hemilaryngeal preparations were used. The RLN was serially stimulated with increasing intensities until the nerve was maximally stimulated. The CMAP amplitude was measured for each intensity stimulation and correlated. Next, the RLN was incompletely transected, and the reduction in CMAP amplitude was correlated to the percentage of transected axons. The percentage of transected axons was determined using horseradish peroxidase (HRP) staining. Results: Combining all hemilaryngeal preparations, the submaximal stimulation of the RLN linearly correlated with the resultant CMAP amplitude (r = 0.83; 95% CI, 0.76-0.88). Following partial RLN transection, the percentage of remaining axons linearly correlated with the CMAP amplitude (r = 0.87; 95% CI, 0.34-0.98). Conclusions: CMAP amplitude is a quantitative measure that may correlate with the degree of vocal fold innervation in canines. Following RLN injury, CMAP may help clinicians quantify the number of intact axons, assess the likelihood of recovery, and counsel patients on their prognosis.
APA, Harvard, Vancouver, ISO, and other styles
36

Kitagawa, Hideki, Hiroshi Nakamura, Yoshiharu Kawaguchi, Haruo Tsuji, Toshihiko Satone, Haruo Takano, and Shinichi Nakatoh. "Magnetic-Evoked Compound Muscle Action Potential Neuromonitoring in Spine Surgery." Spine 20, Supplement (October 1995): 2233–39. http://dx.doi.org/10.1097/00007632-199510001-00010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
37

Van Dijk, J. Gert, and Bastiaan J. Van der Hoeven. "Compound muscle action potential cartography of an accessory peroneal nerve." Muscle & Nerve 21, no. 10 (October 1998): 1331–33. http://dx.doi.org/10.1002/(sici)1097-4598(199810)21:10<1331::aid-mus15>3.0.co;2-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Ackermann, Karin A., Lukas Brander, Daniel Tuchscherer, Ralph Schröder, Stephan M. Jakob, Jukka Takala, and Werner J. Z'graggen. "Esophageal versus surface recording of diaphragm compound muscle action potential." Muscle & Nerve 51, no. 4 (February 24, 2015): 598–600. http://dx.doi.org/10.1002/mus.24577.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Krarup, Christian. "Compound sensory action potential in normal and pathological human nerves." Muscle & Nerve 29, no. 4 (2004): 465–83. http://dx.doi.org/10.1002/mus.10524.

Full text
APA, Harvard, Vancouver, ISO, and other styles
40

Nandedkar, Sanjeev D., and Paul E. Barkhaus. "Contribution of reference electrode to the compound muscle action potential." Muscle & Nerve 36, no. 1 (2007): 87–92. http://dx.doi.org/10.1002/mus.20798.

Full text
APA, Harvard, Vancouver, ISO, and other styles
41

Goodman, Brent P., C. Michel Harper, and Andrea J. Boon. "Prolonged compound muscle action potential duration in critical illness myopathy." Muscle & Nerve 40, no. 6 (October 7, 2009): 1040–42. http://dx.doi.org/10.1002/mus.21445.

Full text
APA, Harvard, Vancouver, ISO, and other styles
42

Scott, William C., Christopher K. Giardina, Andrew K. Pappa, Tatyana E. Fontenot, Meredith L. Anderson, Margaret T. Dillon, Kevin D. Brown, et al. "The Compound Action Potential in Subjects Receiving a Cochlear Implant." Otology & Neurotology 37, no. 10 (December 2016): 1654–61. http://dx.doi.org/10.1097/mao.0000000000001224.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Shore, Susan E., and Alfred L. Nuttall. "The effects of cochlear hypothermia on compound action potential tuning." Journal of the Acoustical Society of America 77, no. 2 (February 1985): 590–98. http://dx.doi.org/10.1121/1.391877.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

Leandri, Massimo, Moreno Saturno, Michele Cilli, Michela Bisaglia, and Gianluigi Lunardi. "Compound action potential of sensory tail nerves in the rat." Experimental Neurology 203, no. 1 (January 2007): 148–57. http://dx.doi.org/10.1016/j.expneurol.2006.08.001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Patel, Mihir R., Jocelyn C. Stamat, Carlton J. Zdanski, Charles S. Ebert, and Jiri Prazma. "Nitric oxide in glutamate-induced compound action potential threshold shifts." Hearing Research 239, no. 1-2 (May 2008): 54–59. http://dx.doi.org/10.1016/j.heares.2008.01.007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
46

Price, John M., and Kenneth R. Henry. "Latency enhancement of the cochlear nerve compound action potential (CAP)." Hearing Research 63, no. 1-2 (November 1992): 97–101. http://dx.doi.org/10.1016/0378-5955(92)90078-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Bostock, H., A. B. Jacobsen, and H. Tankisi. "Motor unit number index and compound muscle action potential amplitude." Clinical Neurophysiology 130, no. 9 (September 2019): 1734–40. http://dx.doi.org/10.1016/j.clinph.2019.05.031.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

OLIVEIRA, JADE DE, MARCOS R. STRALIOTTO, GIANNI MANCINI, CLAUDIA P. FIGUEIREDO, ANTÔNIO L. BRAGA, JOÃO B. R. TEIXEIRA, and ANDREZA F. BEM. "Atheroprotective action of a modified organoselenium compound: in vitro evidence." Anais da Academia Brasileira de Ciências 88, no. 3 suppl (October 10, 2016): 1953–65. http://dx.doi.org/10.1590/0001-3765201620150760.

Full text
Abstract:
ABSTRACT Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organoselenium compounds have demonstrated promising atheroprotective properties in experimental models. Herein, we tested the in vitro atheroprotective capability of a modified organoselenium compound, Compound HBD, in protecting isolated LDL from oxidation as well as foam cells formation. Moreover, the glutathione peroxidase (GPx)-like activity of Compound HBD was analyzed in order to explore the mechanisms related to the above-mentioned protective effects. The Compound HBD in a concentration-dependent manner reduced the Cu2+-induced formation of conjugated dienes. The protein portion from LDL were also protected from Cu2+-induced oxidation. Furthermore, the Compound HBD efficiently decreased the foam cell formation in J774 macrophage cells exposed to oxidized LDL. We found that the atheroprotective effects of this compound can be, at least in part, related to its GPx-like activity. Our findings demonstrated an impressive effect of Compound HBD against LDL-induced toxicity, a further in vivo study to investigate in more detail the antioxidant and antiatherogenic effects of this compound could be considered.
APA, Harvard, Vancouver, ISO, and other styles
49

Bi, Yan-Hua, Li-hua Zhang, Shao-jun Chen, and Qing-zhi Ling. "Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/4509892.

Full text
Abstract:
Curcumae Rhizoma, a traditional Chinese medication, is commonly used in both traditional treatment and modern clinical care. Its anticancer effects have attracted a great deal of attention, but the mechanisms of action remain obscure. In this study, we screened for the active compounds of Curcumae Rhizoma using a drug-likeness approach. Candidate protein targets with functions related to cancer were predicted by reverse docking and then checked by manual search of the PubMed database. Potential target genes were uploaded to the GeneMANIA server and DAVID 6.8 database for analysis. Finally, compound-target, target-pathway, and compound-target-pathway networks were constructed using Cytoscape 3.3. The results revealed that the anticancer activity of Curcumae Rhizoma potentially involves 13 active compounds, 33 potential targets, and 31 signaling pathways, thus constituting a “multiple compounds, multiple targets, and multiple pathways” network corresponding to the concept of systematic actions in TCM. These findings provide an overview of the anticancer action of Curcumae Rhizoma from a network perspective, as well as setting an example for future studies of other materials used in TCM.
APA, Harvard, Vancouver, ISO, and other styles
50

Henry, Kenneth R. "Forward masking and unmasking of the offset cochlear compound action potential of the gerbil: Comparison with suppression areas of the onset cochlear compound action potential." Hearing Research 30, no. 1 (January 1987): 1–10. http://dx.doi.org/10.1016/0378-5955(87)90176-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography