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Journal articles on the topic 'Compound 1080'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

GOH, CSS, DR HODGSON, SM FEARNSIDE, J. HELLER, and N. MALIKIDES. "Sodium monofluoroacetate (Compound 1080) poisoning in dogs." Australian Veterinary Journal 83, no. 8 (August 2005): 474–79. http://dx.doi.org/10.1111/j.1751-0813.2005.tb13296.x.

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2

Notman, Peter. "A review of invertebrate poisoning by compound 1080." New Zealand Entomologist 12, no. 1 (January 1989): 67–71. http://dx.doi.org/10.1080/00779962.1989.9722569.

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3

Obrien, PH, BS Lukins, and JA Beck. "Bait Type Influences the Toxicity of Sodium Monofluoroacetate (Compound 1080) to Feral Pigs." Wildlife Research 15, no. 4 (1988): 451. http://dx.doi.org/10.1071/wr9880451.

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The toxicity of sodium monofluoroacetate (1080) to captive feral pigs was compared in wheat and pellet bait. Mortality following 4.34 mg 1080 kg-1 was significantly higher among pigs receiving 1080 in wheat bait (60%, 24/40) than in pellet bait (28%, 11/40, X*2=7.31, 1 d.f., P<O.05). There were no significant differences between pigs receiving each bait type in terms of time until vomiting began, frequency, mass of vomitus produced, or in time until death. The amount and concentration of 1080 in vomitus and the proportion of 1080 dose ejected were unrelated to bait type. Surviving pigs produced vomitus with a greater 1080 concentration but smaller mass than those that died. Bait type is an important determinant of the toxicity of 1080 to captive feral pigs and should be closely evaluated before specific bait types are used in the field.

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4

Kramer, HL, PW Merrell, and BJ Burren. "Use of Sodium Fluoroacetate (Compound-1080) in the Control of Dingoes .1. Meat Bait Preparation Techniques." Wildlife Research 14, no. 1 (1987): 65. http://dx.doi.org/10.1071/wr9870065.

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Injection and mixing techniques for the preparation of fresh meat baits containing sodium monofluoroacetate (1080) were evaluated. Both techniques produced baits containing variable quantities of 1080. The injection of 1 ml of 6.0-mg ml-1 1080 and 0.5 ml of 13.6-mg ml-1 1080 solution produced baits containing (mean � SD) 2.9 � 0.6 and 3.5 � 0.5 mg of 1080 respectively; the ranges were 1.9-4.1 and 2.1-4.4 mg respectively. Decreasing the injection volume while increasing the 1080 concentration did not increase the percentage of 1080 recovered from baits. Mixed baits prepared by tumbling with 1 ml of 5.7-mg ml-1 1080 and 1 ml of 10-mg ml-1 1080 per bait contained 3.8 � 1.9 and 5.3 � 2.1 mg of 1080 respectively, with respective ranges of 1.2-11.3 and 1.2-13.2 mg per bait. The injection method produced baits more uniform with respect to the amount of 1080 in the bait. A significant fraction of the 1080 added in both methods of preparation was not found. Experiments showed that this loss was due to biochemical reaction rather than physical loss.

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5

O'Halloran, Kathryn, Denise Jones, Lynn Booth, and Penny Fisher. "ECOTOXICITY OF SODIUM FLUOROACETATE (COMPOUND 1080) TO SOIL ORGANISMS." Environmental Toxicology and Chemistry 24, no. 5 (2005): 1211. http://dx.doi.org/10.1897/04-424r.1.

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6

Allender, William J. "Determination of Sodium Fluoroacetate (Compound 1080) in Biological Tissues." Journal of Analytical Toxicology 14, no. 1 (January 1, 1990): 45–49. http://dx.doi.org/10.1093/jat/14.1.45.

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7

Obrien, PH, and BS Lukins. "Factors Influencing the Intake of Sodium Monofluoroacetate (Compound-1080) by Free-Ranging Feral Pigs." Wildlife Research 15, no. 3 (1988): 285. http://dx.doi.org/10.1071/wr9880285.

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Post-mortem investigations of 207 feral pigs poisoned in the field were conducted to assess the influence on 1080 dose of bait type, site, sex, bodyweight and distance from bait stations. The stomachs of most (126/207) pigs contained only bait material., Bait type significantly affected intake and 1080 dose, with pellet intake greater than cereal baits. Sex and bodyweight also influenced intake: females ingested significantly larger 1080 doses than males; and larger pigs tended to consume more bait in absolute terms but lower doses of 1080 (mg kg-1). Average intake of 1080 varied widely at different locations. Pigs that died close to bait stations had higher 1080 doses but smaller proportions of bait in their stomach contents than those that died away from bait stations.

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8

Lee, Jung Im, Myoung K. Kwak, Hee Y. Park, and Youngwan Seo. "Cytotoxicity of Meroterpenoids from Sargassum Siliquastrum against Human Cancer Cells." Natural Product Communications 8, no. 4 (April 2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800403.

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The cytotoxicity of the brown alga Sargassum siliquastrum on human cancer cells (AGS, HT-29, HT-1080, and MCF-7) was investigated. Bioassay-guided fractionation of the crude extracts showed that the 85% aq. methanol (MeOH) fraction was the most toxic. Seven known meroterpenoids (1-7) were isolated from this cytotoxic fraction. Each compound was evaluated for its cytotoxic effect on human cancer cells. Compounds 1, 2, and 4 showed strong cytotoxicity against AGS, HT-29, and HT-1080 cell lines, with IC50 values ranging from 0.5 to 5.7 μg/mL.

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9

Obrien, PH. "The Toxicity of Sodium Monofluoroacetate (Compound 1080) to Captive Feral Pigs, Sus-Scrofa." Wildlife Research 15, no. 2 (1988): 163. http://dx.doi.org/10.1071/wr9880163.

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The toxicity of sodium monofluoroacetate (1080) to captive feral pigs, Sus scrofa, was assessed over a range of doses (1.50-21.3 mg 1080 kg-1 bodyweight) administered orally in wheat bait to 80 animals. Calculated LD*50 was 4.11 mg 1080 kg-1 (95% fiducial limits: 3.02-5.34 mg kg-1) and LD*9O was 11.25 mg kg-1 (8.05-21.69 mg kg-1). The incidence (98%) and frequency (mean � SD = l3.6 � 6.7 overall) of vomiting were high. Frequency of vomiting was unrelated to log*10 dose (r= -0.015; N= 80; NS), although time until vomiting began (r= -0.558; N=77; P<O.05) and time until death (r= -0.391; N=47; P<0.05) had a significant negative association with log*10 dose. Median latency was 49 min (range 10-350 min; N=77) and median time until death was 244 min (range 131-7200 min; N=47). Sex and bodyweight had no effect on frequency of vomiting, time until death or prognosis. Feral pigs yere much less sensitive to 1080 under these test conditions than those in earlier studies. Because the present experiment seems likely to resemble field situations, these results warrant careful examination of field intake and mortality of feral pigs during 1080 poisoning.

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10

Hornshaw, T. C., R. K. Ringer, R. J. Aulerich, and H. H. Casper. "Toxicity of sodium monofluoroacetate (Compound 1080) to mink and European ferrets." Environmental Toxicology and Chemistry 5, no. 2 (February 1986): 213–23. http://dx.doi.org/10.1002/etc.5620050213.

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11

Rathore, AK. "Influence of 1080 bait colour on acceptability by target species and removal by non-target animals." Rangeland Journal 7, no. 2 (1985): 140. http://dx.doi.org/10.1071/rj9850140.

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Baiting trials with meat and carrot baits poisoned with Compound 1080 were carried out on the periphery of three National Parks in New South Wales. The number of meat baits removed by birds was variable, but averaged 28% (+ 11). Colouring the meat baits green significantly reduced the number takenby birds, but did not affect their attractiveness to dogs and foxes. Poisoned carrot dyed green was as effectwe as undyed carrot in controlling rabbits. Reduction in rabbit populations using quarter concentration 1080 (0.083 mg 1080/ g of carrot) was comparable to that from usmg the standard concentration 1080 (0.333 mg 1080/ g of carrot). The use of lower concentration of 1080 in poisoning rabbits is more acceptable ecologically as it may reduce the risk of primary and secondary poisoning of non-target fauna.

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12

Wong, DH, JE Kinnear, and CF Runham. "A Simple Rapid Bioassay for Compound 1080 (Sodium Fluoroacetate) in Bait Materials and Soil-Its Technique and Applications." Wildlife Research 22, no. 5 (1995): 561. http://dx.doi.org/10.1071/wr9950561.

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A simple rapid microbial bioassay for sodium fluoroacetate (Compound 1080) in biological materials and soil is described. The technique measures 1080 directly and only requires basic microbiological laboratory facilities and equipment. It greatly simplfies the analyses of 1080 in bait materials such as oat grains and meat. Some suggested applications of the bioassay are quality control of manufactured baits, the measurement of the toxic lifespan of baits exposed to a range of environmental conditions in the field, and the design and evaluation of new bait types.

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13

Parry, Emily, and Stuart A. Willison. "Direct aqueous injection of the fluoroacetate anion in potable water for analysis by liquid chromatography tandem mass-spectrometry." Analytical Methods 10, no. 46 (2018): 5524–31. http://dx.doi.org/10.1039/c8ay02046a.

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14

Wong, D. H., C. F. Runham, L. C. DenHollander, and J. E. Kinnear. "A preliminary report on a bacteriological assay for compound 1080 (sodium monofluoroacetate)." Letters in Applied Microbiology 12, no. 5 (May 1991): 161–63. http://dx.doi.org/10.1111/j.1472-765x.1991.tb00530.x.

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15

Lin, Shiue, Wu, and Lin. "Dissimilar Infrared Brazing of CoCrFe(Mn)Ni Equiatomic High Entropy Alloys and 316 Stainless Steel." Crystals 9, no. 10 (October 9, 2019): 518. http://dx.doi.org/10.3390/cryst9100518.

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Dissimilar infrared brazing of CoCrFeMnNi/CoCrFeNi equiatomic high entropy alloys and 316 stainless steel using MBF601 and BNi-2 foils was evaluated. The wetting angles of the two fillers at 50 °C above their liquidus temperatures on the three substrates were below 40 degrees. The CoCrFeMnNi/316 SS joint had the highest shear strength of 361 MPa with BNi-2 filler brazing at 1020 °C for 180 s, and fractured at the CrB compound in the joint. The CoCrFeMnNi/MBF601/316 SS joint contained a CoCrFeMnNi-based matrix, phosphides and B-containing compounds. The CoCrFeNi/316 SS joint had the highest shear strength of 374 MPa when brazed with BNi-2 filler at 1020 °C for 600 s, and fractured at the CrB in the joint. The CoCrFeNi/MBF601/316 SS joint consisted of a (Fe,Ni)-rich matrix, phosphides and B/Cr/Fe/P compounds, and the highest shear strength of 324 MPa was achieved when it was brazed at 1080 °C for 600 s.

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16

Hugghins, Ernest J., Howard H. Casper, and C. David Ward. "Tissue Fluoroacetate Residues in Prairie Dogs Dosed with Low-Level Sodium Monofluoroacetate." Journal of AOAC INTERNATIONAL 71, no. 3 (May 1, 1988): 579–81. http://dx.doi.org/10.1093/jaoac/71.3.579.

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Abstract A total of 83 black-tailed prairie dogs (Cynomys ludovicianus) from South Dakota were subjected to low-level treatment with sodium monofluoroacetate (Compound 1080) in the laboratory (0.01-0.30 mg 1080/kg). The acute oral median lethal dose (LD50) of 1080 administered by oral gavage was established at 0.173 mg/kg. To assay fluoroacetate residues, 8 kinds of tissue from each of 10 prairie dogs dead of low-level 1080 poisoning were analyzed by capillary gas chromatography-mass spectrometry. Of the total of 79 tissues analyzed, 73 contained <100 ppb fluoroacetate, and 67 contained <50 ppb fluoroacetate. To test the effect of secondary poisoning on nontarget species, 8 European ferrets (Mustela furo) were fed ground whole carcasses of prairie dogs dead of low-level 1080 poisoning, with no observable ill effects on the ferrets

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17

Parkes, JP. "Phytotoxicity, Poison Retention, Palatability, and Acceptance of Carriers Used in Compound-1080-Foliage Baits for Control of Feral Goats." Wildlife Research 18, no. 6 (1991): 687. http://dx.doi.org/10.1071/wr9910687.

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Feral goats have been controlled in New Zealand by treating leaves of favoured food plants with the poison sodium monofluoroacetate (compound 1080) in a suitable carrier, either carbopol gel or petrolatum grease. The effect of these 2 carriers on the most suitable plant species (mahoe), their retention of 1080, their comparative palatability to goats, and the acceptance of the least palatable, petrolatum, were studied in a series of trials. Both carriers caused baited leaves to absciss, and the rate of abscission increased when 1080 was included. Toxic petrolatum was 3 times less phytotoxic than carbopol and retained 1080 for much longer (carbopol lost most of its toxin after 200 mm of rain). Abscissed petrolatum-treated leaves retained much of their toxicity for at least a year. Goats detected and, to some extent, rejected leaves of all treatments, either by not eating them or by spitting them out (particularly petrolatum-treated leaves). However, use of iophenoxic acid as a bait marker indicated that even petrolatum-treated leaves were consumed by 24 of 30 goats tested. Carbopol with 1080 is recommended for use where its distribution is sufficient to place all goats at immediate risk. Petrolatum is not recommended for general use, although it can be used in areas where a long-life bait is needed.

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18

Mead, RJ, DL Moulden, and L. E Twigg. "Significance of Sulfhydryl Compounds in the Manifestation of Fluoroacetate Toxicity to the Rat, Brush-tailed Possum, Woylie and Western Grey Kangaroo." Australian Journal of Biological Sciences 38, no. 1 (1985): 139. http://dx.doi.org/10.1071/bi9850139.

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Levels of citrate in kidneys and livers of rats with normal glutathione levels increased 6' 8- and I . 7 ?fold respectively 2 h after dosing with I . 5 mg of compound 1080 (= 95% sodium fluoroacetate) per kilogram body weight.

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19

Eason, C. T. "A 90-Day Toxicological Evaluation of Compound 1080 (Sodium Monofluoroacetate) in Sprague-Dawley Rats." Toxicological Sciences 69, no. 2 (October 1, 2002): 439–47. http://dx.doi.org/10.1093/toxsci/69.2.439.

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20

Tomkins, Bruce A. "Screening Procedure for Sodium Fluoroacetate (Compound 1080) at Sub-microgram/gram Concentrations in Soils." Analytical Letters 27, no. 14 (November 1994): 2703–18. http://dx.doi.org/10.1080/00032719408006001.

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21

Kononen, Douglas W., John R. Hochstein, and Robert K. Ringer. "Mallard and northern bobwhite exposure to compound 1080: Acute toxicity and food avoidance behavior." Chemosphere 22, no. 7 (January 1991): 655–63. http://dx.doi.org/10.1016/0045-6535(91)90293-m.

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22

Abele, Edgars, Ramona Abele, Lena Golomba, Ilona Domracheva, Tatjana Beresneva, Elina Jaschenko, and Anita Gulbe. "Novel Chemical Method for Decreasing of Toxicity of Highly Cytotoxic Amidoximes by Introduction of Benzo[4,5]imidazo[2,1-b]thiazolyl Fragment." Current Organic Synthesis 15, no. 8 (December 17, 2018): 1154–60. http://dx.doi.org/10.2174/1570179415666180720113135.

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Aims and Objectives: The aim of the research is to obtain and to investigate the cytotoxicity of a novel class of non-toxic oximes – derivatives of N-(benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-ω- (hetarylsulfanyl)-alkanamidines. Materials and Methods: To assess the possible toxicity of the compounds, acute oral LD50 was calculated. The calculations were based on tested compounds IC50 values in relation to 3T3 (mouse fibroblast cell line) using NRU assay. Monolayer tumor cell lines HT-1080 (human fibrosarcoma, ATCC® CCL-121™), MH-22A (mouse hepatoma, ECACC code, 96121721) and NIH/3T3 (mouse Swiss Albino embryo fibroblasts, ATCC® CRL-1658™), were cultured in standard medium (Dulbecco`s modified Eagle`s medium) supplemented with 10% fetal bovine serum (“Sigma”). Results: E-Stereoselective synthesis of novel N-(benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-ω- (hetarylsulfanyl)alkanamidines as potential cytotoxic agents was carried out in three steps from corresponding thiones. N-(Benzo[4,5]imidazo[2,1-b]thiazol-3-ylmethoxy)-5-(benzothiazol-2-ylsulfanyl)-pentanamidine exhibits high activity in vitro on the monolayer tumour cell lines: MG-22A (mouse hepatoma) and HT-1080 (human fibrosarcoma). Besides this, the above compound exhibits low toxicity on the 3T3 cell line and low estimated acute oral LD50 (LD50 2759 mg/kg). Conclusion: In conclusion, such dramatic decreasing of expected acute toxicity and high cytotoxicity by the introduction of benzo[4,5]imidazo[2,1-b]thiazolyl fragment into N-hydroxy-ω-(hetarylsulfanyl)alkanamidines were demonstrated for the first time (see, for example, toxicity and cytotoxicity of compound 8b and corresponding unsubstituted oxime).

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23

Guo, Qi, Bo-Jin Pan, Jia Yu, Bin-Bin Ruan, Dong-Yun Chen, Xiao-Chuan Wang, Qing-Ge Mu, Gen-Fu Chen, and Zhi-An Ren. "Superconductivity at 7.8 K in the ternary LaRu 2 As 2 compound." Science Bulletin 61, no. 12 (June 2016): 921–24. http://dx.doi.org/10.1007/s11434-016-1080-4.

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24

Kim, Hojun, Fatih Karadeniz, Chang-Suk Kong, and Youngwan Seo. "Evaluation of MMP Inhibitors Isolated from Ligustrum japonicum Fructus." Molecules 24, no. 3 (February 8, 2019): 604. http://dx.doi.org/10.3390/molecules24030604.

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The current study investigated the ability of two secoiridoids, GL-3 (1) and oleonuezhenide (2), isolated from the fruits of Ligustrum japonicum to inhibit MMP-2 and -9 activity in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 human fibrosarcoma cells. Both compounds 1 and 2 were able to exert lowered gelatin digestion activity for MMP-2 and -9 tested by gelatin zymography via suppressing the release of MMPs to culture medium according to ELISA results. Treatment with compounds was also able to suppress the expression of both mRNA and protein levels of MMP-2 and -9. Action mechanism behind the MMP inhibitory effect of the compounds was suggested to be via MAPK pathway indicated by decreased levels of phosphorylated p38, ERK and JNK proteins evaluated employing immunoblotting. Compound 1 was shown to be slightly more active to inhibit MMP-2 and -9, however, compound 2 showed more regular dose-dependency during inhibition. In conclusion, this study suggested that GL-3 and oleonuezhenide were notable natural origin potent MMP inhibitors and could serve as lead compounds for development of anti-invasive MMP inhibitors against tumor metastasis.

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25

Frost, Ray L., Robert W. Parker, and John V. Hanna. "Detection of the pesticide compound 1080 (sodium monofluoroacetate) using fluorine-19 nuclear magnetic resonance spectroscopy." Analyst 114, no. 10 (1989): 1245. http://dx.doi.org/10.1039/an9891401245.

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26

SENDAI, MICHIYUKI, SHOHEI HASHIGUCHI, MITSUMI TOMIMOTO, SHOJI KISHIMOTO, TAISUKE MATSUO, and MICHIHIKO OCHIAI. "Synthesis of carumonam (AMA-1080) and a related compound starting from (2R,3R)-epoxysuccinic acid." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 9 (1985): 3798–810. http://dx.doi.org/10.1248/cpb.33.3798.

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27

Li, Yun-long, Jie Li, Chun-yin Yan, Ze-feng Lai, and Gui-jie Hu. "Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?" Chinese Journal of Integrative Medicine 20, no. 1 (February 27, 2012): 63–67. http://dx.doi.org/10.1007/s11655-012-1080-4.

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28

Hsiao, Sui-Wen, Yu-Chin Wu, Hui-Ching Mei, Yu-Hsin Chen, George Hsiao, and Ching-Kuo Lee. "Constituents of Aquilaria sinensis Leaves Upregulate the Expression of Matrix Metalloproteases 2 and 9." Molecules 26, no. 9 (April 26, 2021): 2537. http://dx.doi.org/10.3390/molecules26092537.

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In this novel study, we isolated 28 compounds from the leaves of Aquilaria sinensis (Lour.) Gilg based on a bioassay-guided procedure and also discovered the possible matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) modulatory effect of pheophorbide A (PA). To evaluate the regulatory activity on MMP-2 and MMP-9, the HT-1080 human fibrosarcoma cells were treated with various concentrations of extracted materials and isolated compounds. PA was extracted by methanol from the leaves of A. sinensis and separated from the fraction of the partitioned ethyl acetate layer. PA is believed to be an active component for MMP expression since it exhibited significant stimulation on MMP-2 and proMMP-9 activity. When treating with 50 μM of PA, the expression of MMP-2 and MMP-9 were increased 1.9-fold and 2.3-fold, respectively. PA also exhibited no cytotoxicity against HT-1080 cells when the cell viability was monitored. Furthermore, no significant MMP activity was observed when five PA analogues were evaluated. This study is the first to demonstrate that C-17 of PA is the deciding factor in determining the bioactivity of the compound. The MMP-2 and proMMP-9 modulatory activity of PA indicate its potential applications for reducing scar formation and comparative medical purposes.

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29

Letnic, M., and M. S. Crowther. "Pesticide use is linked to increased body size in a large mammalian carnivore." Biological Journal of the Linnean Society 131, no. 1 (July 31, 2020): 220–29. http://dx.doi.org/10.1093/biolinnean/blaa084.

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Abstract Pollution and pesticide use have been linked to evolution of chemical resistance and phenotypic shifts in invertebrates, but less so in vertebrates. Here we provide evidence that poisoning directed towards a mammalian carnivore, the dingo (Canis dingo), is linked to an increase in dingo body mass. We compared the skull length of dingoes, a proxy for size, from three regions where dingo populations were controlled by distributing poisoned meat baits and an unbaited region, before and after the introduction of the toxin sodium fluoroacetate (Compound 1080). Following 1080 introduction, dingo skull length increased in baited regions but not in the unbaited region. We estimate that after 1080 introduction, the skull length of female and male dingoes in baited regions increased by 4.49 and 3.6 mm, respectively. This equates to a 1.02- and 0.86-kg increase in mean body masses of female and male dingoes, respectively. We hypothesize that dingo body size has increased in baited regions due to 1080 selecting for animals with larger body size or because a reduction in dingo abundance in baited areas may have removed constraints on growth imposed by intraspecific competition and prey availability. Our study provides evidence that pesticide use can prompt phenotypic change in comparatively large and long-lived large vertebrates.

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30

Twigg, Laurie. "Fluoroacetate-bearing vegetation: can it reduce the impact of exotic mammals on wildlife conservation?" Pacific Conservation Biology 17, no. 4 (2011): 299. http://dx.doi.org/10.1071/pc110299.

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THERE is no doubt that fluoroacetate-bearing vegetation (also known as poison peas) has had a profound effect on the evolution and persistence of Western Australian biota. Most of these plants belong to the genus Gastrolobium, and most are found in the south-west corner of Western Australia (Gardner and Bennetts 1956; Aplin 1971; Twigg and King 1991). The toxic principle of these plants, fluoroacetate, is also manufactured synthetically as 1080 (sodium fluoroacetate) for Australiawide control of vertebrate pests, such as rabbits Oryctolagus cuniculus, foxes Vulpes vulpes, wild dogs Canis lupus familiaris and feral Pigs Sus scrofa (Twigg and King 1991). Because of their co-evolution with fluoroacetate-bearing vegetation, many native animals in Western Australia have developed varying levels of tolerance to this highly toxic compound. In contrast, introduced mammals are generally highly sensitive to fluoroacetate. Although it is not a prerequisite for safe and effective pest control programmes with 1080, the toxicity differential between native and introduced animals provides an additional “safety net” when using 1080 products in Western Australia.

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31

Warburton, B. "Control of Bennett's and Tammar Wallabies in New Zealand Using Compound 1080 Gel on Foliage Baits." Wildlife Research 17, no. 5 (1990): 541. http://dx.doi.org/10.1071/wr9900541.

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Trials were carried out against Bennett's wallabies (Macropus rufogriseus rufogriseus) and tammar wallabies (M. eugenii) in areas of indigenous forest where browsing is preventing or damaging regeneration. Compound 1080 (sodium monofluoroacetate) in a carbopol gel was spread on the foliage of palatable plants. Numbers of Bennett's wallabies were reduced by 91% and tammar wallabies by 87%. These kill estimates compare favourably with those achieved using aerially sown baits. The costs per hectare of gel poisoning were estimated to be as little as 40% of those for aerial baiting, but the costs of using gel will increase as the control areas become larger, more rugged, and less easily traversed on foot.

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32

Wright, G. R. G., L. H. Booth, G. A. Morriss, M. D. Potts, L. Brown, and C. T. Eason. "Assessing potential environmental contamination from compound 1080 (sodium monofluoroacetate) in bait dust during possum control operations." New Zealand Journal of Agricultural Research 45, no. 1 (January 2002): 57–65. http://dx.doi.org/10.1080/00288233.2002.9513493.

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33

Burns, R. J., and G. E. Connolly. "Assessment of potential toxicity of Compound 1080 from livestock protection collars to canines and scavenging birds." International Biodeterioration & Biodegradation 36, no. 1-2 (January 1995): 161–67. http://dx.doi.org/10.1016/0964-8305(95)00057-7.

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34

Ogilvie, Shaun C., James M. Ataria, James Waiwai, James E. Doherty, Michelle Lambert, Neuton Lambert, and David King. "Uptake and Persistence of the Vertebrate Pesticide, Sodium Monofluoroacetate (Compound 1080), in Plants of Cultural Importance." Ecotoxicology 15, no. 1 (November 30, 2005): 1–7. http://dx.doi.org/10.1007/s10646-005-0039-z.

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35

Tabaszewska, Małgorzata, Agata Antoniewska, Jaroslawa Rutkowska, Łukasz Skoczylas, Jacek Słupski, and Radosława Skoczeń-Słupska. "Bioactive Components, Volatile Profile and In Vitro Antioxidative Properties of Taxus baccata L. Red Arils." Molecules 26, no. 15 (July 24, 2021): 4474. http://dx.doi.org/10.3390/molecules26154474.

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This study aimed at assessing the composition of bioactive compounds, including ascorbic acid, carotenoids and polyphenols, the volatile compound profile and the antioxidant activity of red arils (RAs) of Taxus baccata L. grown in diverse locations in Poland. Among the carotenoids assayed in high quantities (3.3–5.42 μg/g), the lycopene content (2.55–4.1 μg/g) was remarkably higher than that in many cultivated fruits. Samples collected from three sites were distinguished by higher amounts of ascorbic acid (125 mg/100 g, on average) than those found in many cultivated berries. Phenylpropanoids quantitatively dominated among the four groups of phenolic compounds. Chromatographic separation enabled the detection of two phenylpropanoid acids: ferulic and p-coumaric. Irrespectively of the growth site, RAs contained substantial amounts of (-)-epicatechin (1080 μg/100 g, on average). A higher ability to scavenge DPPH● and ABTS●+ radicals was found in the hydrophilic fraction of RAs from two sites (Warsaw and Koszalin) compared with the other two sites. The volatile compound profile of RAs was dominated by alcohols, followed by ketones, esters and aldehydes. The presence of some volatiles was exclusively related to the specific growth site, which may be regarded as a valuable indicator. The combination of bioactive and volatile compounds and the fairly good antioxidant potential of RAs render them an attractive source for preparing functional foods.

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Allender, W. J. "The Determination of Sodium Monofluoroacetate (Compound 1080) in Formulation and Technical Samples by High Pressure Liquid Chromatography." Journal of Liquid Chromatography 13, no. 17 (November 1990): 3465–71. http://dx.doi.org/10.1080/01483919008049114.

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Körtner, Gerhard, and Peter Watson. "The immediate impact of 1080 aerial baiting to control wild dogs on a spotted-tailed quoll population." Wildlife Research 32, no. 8 (2005): 673. http://dx.doi.org/10.1071/wr05014.

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In eastern Australia, the spotted-tailed quoll (Dasyurus maculatus) is the species thought to be most likely at risk from aerial baiting with compound 1080 to control wild dogs (Canis lupus familiaris and C. l. dingo). Although it is known that quolls occasionally die of 1080 poisoning, the broader impact on populations remains unresolved. We therefore assessed the impact of a regular aerial baiting campaign on a population of spotted-tailed quolls. Baiting with 1080 meat baits was conducted by the local Wild Dog Control Association and followed the same procedure as in previous years with the exception that the biomarker, rhodamine B, was added to the baits. Prior to the baiting, 36 quolls were trapped and fitted with mortality radio-collars; 31 of these collars were still functional at the time of baiting. Quolls were monitored from a helicopter and on the ground until retrapped 5–9 weeks after baiting. Transmitters were then removed and a sample of vibrissae was taken for rhodamine B analysis. Carcasses found were analysed for 1080. Predator numbers were assessed before and after baiting using track pads across trails. Among the initial 36 radio-collared quolls, nine mortalities were recorded during the course of the study (seven after baiting). Only one of the nine deaths could be directly attributed to 1080 poisoning. In addition, vibrissae from five of the 35 individuals sampled after baiting were marked with rhodamine B, indicating that these individuals had consumed bait, and survived. Consequently, mortality attributable to this particular aerial baiting campaign was low, apparently because few quolls ate bait and most of those that did survived. Track counts for predators indicated a significant decrease in dog and fox numbers after baiting. Cat activity remained unchanged and the number of quoll tracks increased.

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Körtner, G. "1080 aerial baiting for the control of wild dogs and its impact on spotted-tailed quoll (Dasyurus maculatus) populations in eastern Australia." Wildlife Research 34, no. 1 (2007): 48. http://dx.doi.org/10.1071/wr06076.

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To further investigate the non-target impact of baiting using sodium monofluoroacetate (compound 1080) to control wild dogs, a population of radio-collared spotted-tailed quolls was subject to an experimental aerial baiting exercise. The trial was conducted at a site on the New England Tablelands, New South Wales, without a recent history of that practice. Sixteen quolls were trapped and radio-collared before baiting. Fresh meat baits were delivered from a helicopter at a rate of 10–40 baits km–1. In addition to 1080 (4.2 mg), each bait contained the bait marker rhodamine B (50 mg), which becomes incorporated into growing hair if an animal survives bait consumption. Two quoll mortalities were recorded following aerial baiting. Both quolls died 3–5 weeks after baiting when baits, on average, retained little 1080. None of the carcasses contained traces of 1080, but the test result is less reliable for the quoll that was found 19 days after its death although tissue was well preserved because of the cool weather. Nevertheless, given that this animal died 34 days after bait delivery, it appears likely that none of the radio-collared quolls succumbed to baiting. In contrast, vibrissae samples collected from 19 quolls captured after the baiting showed that 68% had eaten baits and survived. Furthermore, multiple bait takes were common, with up to six baits consumed by one female. The results demonstrate that most, if not all, quolls survived the baiting trial, including those that consumed dog baits. Hence bait consumption figures per se are not indicative of mortality rates attributable to poisoning.

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Rucins, Martins, Rufus Smits, Anda Sipola, Brigita Vigante, Ilona Domracheva, Baiba Turovska, Ruslan Muhamadejev, et al. "Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds." Oxidative Medicine and Cellular Longevity 2020 (December 31, 2020): 1–17. http://dx.doi.org/10.1155/2020/8413713.

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Three groups of synthetic lipids are chosen for studies: (1) 1,4-dihydropyridines (1,4-DHPs) containing two cationic moieties and their analogues; (2) 3,4-dihydro-2(1H)-pyridones containing a cationic moiety; and (3) acyclic, open-chain analogues, i.e., 2-amino-3-alkoxycarbonylalkylammonium derivatives. 1,4-DHPs possessing dodecyl alkyl chains in the ester groups in positions 3 and 5 and cationic nitrogen-containing groups in positions 2 and 6 have high cytotoxicity in cancer cells HT-1080 (human lung fibrosarcoma) and MH-22A (mouse hepatoma), but low cytotoxicity in the noncancerous NIH3T3 cells (mouse embryonic fibroblast). On the contrary, similar compounds having short (methyl, ethyl, or propoxyethyl) chains in the ester groups in positions 3 and 5 lack cytotoxicity in the cancer cells HT-1080 and MH-22A even at high doses. Inclusion of fluorine atoms in the alkyl chains in positions 3 and 5 of the DHP cycle decreases the cytotoxicity of the mentioned compounds. Structurally related dihydropyridones with a polar head group are substantially more toxic to normal and cancerous cells than the DHP analogues. Open-chain analogues of DHP lipids comprise the same conjugated aminovinylcarbonyl moiety and possess anticancer activity, but they also have high basal cytotoxicity. Electrochemical oxidation data demonstrate that oxidation potentials of selected compounds are in the range of 1.6–1.7 V for cationic 1,4-DHP, 2.0–2.4 V for cationic 3,4-dihydropyridones, and 1.2–1.5 V for 2-amino-3-alkoxycarbonylalkylammonium derivatives. Furthermore, the tested cationic 1,4-DHP amphiphiles possess antiradical activity. Molecular topological polar surface area values for the tested compounds were defined in accordance with the main fragments of compound structures. The determined log P values were highest for dodecyl ester groups in positions 3 and 5 of the 1,4-DHP and lowest for short alkyl chain-containing amphiphiles.

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Allen, LR, PJS Fleming, JA Thompson, and K. Strong. "Effect of Presentation on the Attractiveness and Palatability to Wild Dogs and Other Wildlife of 2 Unpoisoned Wild-Dog Bait Types." Wildlife Research 16, no. 6 (1989): 593. http://dx.doi.org/10.1071/wr9890593.

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Factory-prepared beef crackle cubes and fresh meat baits are routinely used with the poison 1080 to prevent or reduce predation by wild dogs, Canis familiaris. Four field trials totalling 674 bait nights per bait type were conducted in southern Queensland to assess the relative attractiveness and palatability of the two baits to wild dogs and non-target animals. Buried meat and surface-laid meat baits were also compared to assess the effect that bait presentation can have on control programme efficiency and non-target hazard. Fresh meat was found to be significantly more palatable to wild dogs than factory baits. Factory baits, despite being equally attractive to wild dogs as fresh meat, had significantly more visits by wild dogs where baits were not eaten. Fresh meat was significantly more attractive and palatable to non-target species than factory baits. Buried baits were equally attractive and palatable to wild dogs compared with surface-laid meat baits, yet had greatly reduced non-target bait take. The significance of the results is discussed with regard to the potential 1080 hazard to birds and reptiles (which removed 28% and 10% of baits, respectively) and the influence that non-target removal of baits may have on the efficiency and design of wild-dog control programmes. Extra keywords: Compound 1080, poison, SEA, sodium fluoroacetate.

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Rabaglino, Maria Belen, Eileen I. Chang, Elaine M. Richards, Margaret O. James, Maureen Keller-Wood, and Charles E. Wood. "Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation." Endocrinology 157, no. 7 (May 4, 2016): 2686–97. http://dx.doi.org/10.1210/en.2016-1080.

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Triclosan (TCS), an antibacterial compound commonly added to personal care products, could be an endocrine disruptor at low doses. Although TCS has been shown to alter fetal physiology, its effects in the developing fetal brain are unknown. We hypothesize that exposure to TCS during fetal life could affect fetal hypothalamic gene expression. The objective of this study was to use transcriptomics and systems analysis to identify significantly altered biological processes in the late gestation ovine fetal hypothalamus after direct or indirect exposure to low doses of TCS. For direct TCS exposure, chronically catheterized late gestation fetal sheep were infused with vehicle (n = 4) or TCS (250 μg/d; n = 4) iv. For indirect TCS exposure, TCS (100 μg/kg · d; n = 3) or vehicle (n = 3) was infused into the maternal circulation. Fetal hypothalami were collected after 2 days of infusion, and gene expression was measured through microarray. Hierarchical clustering of all samples according to gene expression profiles showed that samples from the TCS-treated animals clustered apart from the controls. Gene set enrichment analysis revealed that fetal hypothalamic genes stimulated by maternal and fetal TCS infusion were significantly enriching for cell cycle, reproductive process, and feeding behavior, whereas the inhibited genes were significantly enriching for chromatin modification and metabolism of steroids, lipoproteins, fatty acids, and glucose (P < .05). In conclusion, short-term infusion of TCS induces vigorous changes in the fetal hypothalamic transcriptomics, which are mainly related to food intake pathways and metabolism. If these changes persist to postnatal life, they could result in adverse consequences in adulthood.

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Hoogenboom, Jacobus J. L., and Colin G. Rammell. "Determination of Sodium Monofluoroacetate (Compound 1080) in Tissues and Baits as its Benzyl Ester By Reaction-Capillary Gas Chromatography." Journal of Analytical Toxicology 11, no. 4 (July 1, 1987): 140–43. http://dx.doi.org/10.1093/jat/11.4.140.

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B. Phillips, R., B. D. Cooke, K. Campbell, V. Carrion, C. Marouez, and H. L. Snell. "Eradicating Feral Cats to protect Galapagos Land Iguanas: methods and strategies." Pacific Conservation Biology 11, no. 4 (2005): 257. http://dx.doi.org/10.1071/pc050257.

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A three-year programme to eradicate Feral Cats Felis catus from the island of Baltra in the Galapagos archipelago achieved good results by initially poisoning with sodium monofluoroacetate (compound 1080) then trapping or shooting the remaining cats. The poisoning campaign removed 90% of the cats, its success being attributable to pre-baiting with unpolsoned baits to accustom cats to eating baits and placing enough baits to ensure that all cats encountered several baits within their home range. This, together with the use of metaclopromide (Pileran) as an anti-emetic, overcame a problem associated with poor retention of 1080 in thawed fish baits that limited the dose available to 1 mg 1080/bait, a quality insufficient to kill large cats. Removal of the remaining cats was delayed by a weather-induced irruption of Black Rats Rattus rattus and House Mice Mus musculus that enabled recruitment of kittens in 2002, but made cats more susceptible to trapping and shooting in 2003 when rodent populations collapsed. Since July 2003 no sign of a cat has been detected on Baltra despite extensive searching and monitoring throughout 2004. As cat abundance has decreased there have been more locally-bred Juvenile iguanas (Conolophus subcristatus) seen during annual censuses. However, such recruitment may reflect the increasing maturity and higher fecundity of iguanas repatriated from 1991 onwards rather than being a direct result of reduced cat predation alone. More time is necessary to determine the benefits of reduced cat predation on the Iguana population.

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Twigg, LE, RJ Mead, and DR King. "Metabolism of Fluoroacetate in the Skink (Tiliqua rugosa) and the Rat (Rattus norvegicus)." Australian Journal of Biological Sciences 39, no. 1 (1986): 1. http://dx.doi.org/10.1071/bi9860001.

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Administration of 100 mg sodium fiuoroacetate (compound 1080) per kilogram body weight to T. rugosa resulted in a 3 �4-fold increase in plasma citrate levels 48 h after dosing while administration of 3 mg sodium fiuoroacetate per kilogram body weight to R. norvegicus produced a fivefold increase in plasma citrate levels within 4 h. Administration of 300 mg sodium fiuoroacetate per kilogram body weight reduced the oxygen consumption of the skink by between 2�5 and 11 % while in the rat, 2 mg sodium fiuoroacetate per kilogram body weight reduced oxygen consumption by between 28 and 57%.

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45

Merks, PF, and MC Calver. "The effect of ant activity on meat baits impregnated with sodium monofluoroacetate (Compound 1080) used for the control of dingoes and wild dogs." Rangeland Journal 11, no. 2 (1989): 83. http://dx.doi.org/10.1071/rj9890083.

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Wild dog and dingo baits impregnated with the toxin 1080 and exposed at two different sites in the field suffered significant reductions in weight compared with controls as a result of ant activity. In one case a bait was completely destroyed in five days, while others were reduced in weight by over 70% during the same period. Sun-drying of baits for 48h before laying did not significantly reduce damage by ants. Ant activity may detoxify baits before they are taken by wild dogs.

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E. Twigg, Laurie, Laurie E. Twigg, Dennis R. King, and Dennis R. King. "Artificially enhanced tolerance to fluoroacetate and its implications for wildlife conservation." Pacific Conservation Biology 6, no. 1 (2000): 9. http://dx.doi.org/10.1071/pc000009.

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It is with some concern that we have been following a research programme aimed at developing non-specific, genetically modified ruminant bacteria capable of detoxifying fluoroacetate (Compound 1080) to protect domestic livestock from fluoroacetate-poisoning (Gregg et al. 1994; Gregg et al. 1998; Synergy 1998). The main thrust of this research programme is the prevention of cattle losses in the Georgina Basin in the Northern Territory and Queensland where the toxic plant, Gidgee Acacia georginae occurs. Although rarely mentioned in formal reports of this work, 1080 is an important vertebrate pesticide that is widely used throughout Australia and New Zealand. It is the first defence against a number of pest species that impact on agricultural production and conservation efforts in both countries. The main concerns about this work relate to the potential lack of target specificity of these modified microorganisms, and also, if released, their potential impact on conservation biology. We raise these questions now because the Genetic Manipulation Advisory Council has been approached for approval to conduct field trials in Western Australia using the modified bacteria. We believe the perceived advantages and disadvantages of these modified organisms need informed debate before such approval, or any general release of these modified rumen bacteria, could be considered.

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Mahdi, J. G., C. J. Pepper, M. A. Alkarrawi, A. J. Mahdi, and I. D. Bowen. "Sub-millimolar concentration of the novel phenol-based compound, 2-hydroxy benzoate zinc, induces apoptosis in human HT-1080 fibrosarcoma cells." Cell Proliferation 43, no. 1 (February 2010): 95–102. http://dx.doi.org/10.1111/j.1365-2184.2009.00658.x.

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Deng, Rong, Jun Tang, Liang-Ping Xia, Dan-Dan Li, Wen-Jun Zhou, Lin-Lin Wang, Gong-Kan Feng, Yi-Xin Zeng, You-Heng Gao, and Xiao-Feng Zhu. "ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway." Molecular Cancer Therapeutics 8, no. 4 (April 2009): 873–82. http://dx.doi.org/10.1158/1535-7163.mct-08-1080.

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Cowan, M., D. Moro, H. Anderson, J. Angus, S. Garretson, and K. Morris. "Aerial baiting for feral cats is unlikely to affect survivorship of northern quolls in the Pilbara region of Western Australia." Wildlife Research 47, no. 8 (2020): 589. http://dx.doi.org/10.1071/wr19141.

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Abstract ContextFeral cats (Felis catus) are known predators of northern quolls (Dasyurus hallucatus). Management to suppress feral cat densities often uses the poison sodium monofluoroacetate (compound 1080) in baits broadcast aerially. Eradicat® baits have demonstrated efficacy at reducing feral cat densities in some environments. However, these are not registered for use in northern Australia because their risk to non-target northern quolls remains unknown. AimsWe investigated the risks of aerially deployed feral cat Eradicat® baits containing 4.5mg of the poison 1080 on the survival of free-ranging northern quolls. MethodsThe study was conducted over a 20000-ha area in the Pilbara bioregion in Western Australia. Twenty-one wild northern quolls from a baited area and 20 quolls from a nearby reference area were fitted with radio-collars, and their survivorship was compared following the aerial deployment of over 9700 feral cat baits. Survivorship of quolls was assessed before and after the baiting campaign. Key resultsFive radio-collared quolls died at the baited area; four mortalities were due to feral cat predation, and the cause of one death was uncertain. At the reference area, seven radio-collared quolls were confirmed dead; three mortalities were due to feral cat predation, two from wild dog predation, and the cause of death of two could not be determined. Evidence for sublethal poison impacts on quolls, inferred by monitoring reproductive output, was lacking; average litter size was higher in quolls from the baited area than in those from the unbaited area, and within range of litters reported elsewhere, suggesting that acute effects of 1080 (if ingested) on reproductive success were unlikely. ConclusionsRadio-collared northern quolls survived the trial using Eradicat® baits, and females showed no acute effects of sublethal poisoning on the basis of reproductive output. A lack of quoll deaths attributed to 1080 poisoning suggests that the use of Eradicat® poses a low risk to northern quolls in the Pilbara. Importantly, the high level of mortalities associated with predation by feral cats, and to a lesser extent, canids, validates the threats of these introduced predators on quolls, suggesting that their control in areas where quolls are present is likely to be beneficial for the recovery of this species. ImplicationsLand managers aiming to conserve northern quolls in the Pilbara would see conservation benefits if they introduced an operational landscape-scale feral cat baiting program using Eradicat® baits, with appropriate monitoring.

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Collicchio-Zuanaze, R. C., M. Sakate, D. S. Schwartz, E. Trezza, and A. J. Crocci. "Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation." Human & Experimental Toxicology 25, no. 4 (April 2006): 175–82. http://dx.doi.org/10.1191/0960327106ht609oa.

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Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade. In the present study, domestic cats were intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The intoxicated animals presented emesis, diarrhea with abdominal pain posture and an abdominal palpation, tachypnea, bilateral midriasis, hypothermia, hyperexcitability and convulsions. Blood gas analysis indicated decreased pH and bicarbonate levels. Serum ionized calcium was also decreased. ECG showed non–specific changes in ventricular repolarization and ventricular arrhythmias. The survival rate was 75% in the treated group with calcium gluconate and sodium succinate and 37.5% in the nontreated group.

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