Relevant bibliographies by topics / Composite Hydrogels

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Academic literature on the topic 'Composite Hydrogels'

Author: Grafiati
Published: 25 May 2024

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Journal articles on the topic "Composite Hydrogels"

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Wu, Hongyi, Nitong Bu, Jie Chen, Yuanyuan Chen, Runzhi Sun, Chunhua Wu, and Jie Pang. "Construction of Konjac Glucomannan/Oxidized Hyaluronic Acid Hydrogels for Controlled Drug Release." Polymers 14, no. 5 (February 25, 2022): 927. http://dx.doi.org/10.3390/polym14050927.

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Konjac glucomannan (KGM) hydrogel has favorable gel-forming abilities, but its insufficient swelling capacity and poor control release characteristics limit its application. Therefore, in this study, oxidized hyaluronic acid (OHA) was used to improve the properties of KGM hydrogel. The influence of OHA on the structure and properties of KGM hydrogels was evaluated. The results show that the swelling capacity and rheological properties of the composite hydrogels increased with OHA concentration, which might be attributed to the hydrogen bond between the KGM and OHA, resulting in a compact three-dimensional gel network structure. Furthermore, epigallocatechin gallate (EGCG) was efficiently loaded into the KGM/OHA composite hydrogels and liberated in a sustained pattern. The cumulative EGCG release rate of the KGM/OHA hydrogels was enhanced by the increasing addition of OHA. The results show that the release rate of composite hydrogel can be controlled by the content of OHA. These results suggest that OHA has the potential to improve the properties and control release characteristics of KGM hydrogels.
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Zheng, Jianuo, Yunping Wang, Yuwen Wang, Ruiping Duan, and Lingrong Liu. "Gelatin/Hyaluronic Acid Photocrosslinked Double Network Hydrogel with Nano-Hydroxyapatite Composite for Potential Application in Bone Repair." Gels 9, no. 9 (September 13, 2023): 742. http://dx.doi.org/10.3390/gels9090742.

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The application of hydrogels in bone repair is limited due to their low mechanical strength. Simulating bone extracellular matrix, methylacrylylated gelatin (GelMA)/methylacrylylated hyaluronic acid (HAMA)/nano-hydroxyapatite(nHap) composite hydrogels were prepared by combining the double network strategy and composite of nHap in this study. The precursor solutions of the composite hydrogels were injectable due to their shear thinning property. The compressive elastic modulus of the composite hydrogel was significantly enhanced, the fracture strength of the composite hydrogel nearly reached 1 MPa, and the composite hydrogel retained its high water content at above 88%. The composite hydrogels possess good compatibility with BMSCS and have the potential to be used as injectable hydrogels for bone defect treatment.
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Nie, Lei, Pengbo Chang, Meng Sun, Haojie Huo, Chunxia Zhang, Chingching Ji, Xiaoyan Wei, Qiuju Zhou, Peiyin Guo, and Hongyu Yuan. "Composite Hydrogels with the Simultaneous Release of VEGF and MCP-1 for Enhancing Angiogenesis for Bone Tissue Engineering Applications." Applied Sciences 8, no. 12 (December 1, 2018): 2438. http://dx.doi.org/10.3390/app8122438.

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Rapid new microvascular network induction was critical for bone regeneration, which required the spatiotemporal delivery of growth factors and transplantation of endothelial cells. In this study, the linear poly(d,l-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (PLGA-mPEG) block copolymer microspheres were prepared for simultaneously delivering vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1). Then, vascular endothelial cells (VECs) with growth factor loaded microspheres were composited into a star-shaped PLGA-mPEG block copolymer solution. After this, composite hydrogel (microspheres ratio: 5 wt%) was formed by increasing the temperature to 37 °C. The release profiles of VEGF and MCP-1 from composite hydrogels in 30 days were investigated to confirm the different simultaneous delivery systems. The VECs exhibited a good proliferation in the composite hydrogels, which proved that the composite hydrogels had a good cytocompatibility. Furthermore, in vivo animal experiments showed that the vessel density and the mean vessel diameters increased over weeks after the composite hydrogels were implanted into the necrosis site of the rabbit femoral head. The above results suggested that the VECs-laden hydrogel composited with the dual-growth factor simultaneous release system has the potential to enhance angiogenesis in bone tissue engineering.
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Elvitigala, Kelum Chamara Manoj Lakmal, Wildan Mubarok, and Shinji Sakai. "Human Umbilical Vein Endothelial Cells Form a Network on a Hyaluronic Acid/Gelatin Composite Hydrogel Moderately Crosslinked and Degraded by Hydrogen Peroxide." Polymers 14, no. 22 (November 20, 2022): 5034. http://dx.doi.org/10.3390/polym14225034.

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The study of the capillary-like network formation of human umbilical vein endothelial cells (HUVECs) in vitro is important for understanding the factors that promote or inhibit angiogenesis. Here, we report the behavior of HUVECs on the composite hydrogels containing hyaluronic acid (HA) and gelatin with different degrees of degradation, inducing the different physicochemical properties of the hydrogels. The hydrogels were obtained through horseradish peroxidase (HRP)-catalyzed hydrogelation consuming hydrogen peroxide (H2O2, 16 ppm) supplied from the air, and the degradation degree was tuned by altering the exposure time to the air. The HUVECs on the composite hydrogel with intermediate stiffness (1.2 kPa) obtained through 120 min of the exposure were more elongated than those on the soft (0.4 kPa) and the stiff (2.4 kPa) composite hydrogels obtained through 15 min and 60 min of the exposure, respectively. In addition, HUVECs formed a capillary-like network only on the stiff composite hydrogel although those on the hydrogels with comparable stiffness but containing gelatin alone or alginate instead of HA did not form the network. These results show that the HA/gelatin composite hydrogels obtained through the H2O2-mediated crosslinking and degradation could be a tool for studies using HUVECs to understand the promotion and inhibition of angiogenesis.
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Murshid, Nimer, Omar Mouhtady, Mahmoud Abu-samha, Emil Obeid, Yahya Kharboutly, Hamdi Chaouk, Jalal Halwani, and Khaled Younes. "Metal Oxide Hydrogel Composites for Remediation of Dye-Contaminated Wastewater: Principal Component Analysis." Gels 8, no. 11 (October 30, 2022): 702. http://dx.doi.org/10.3390/gels8110702.

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Water pollution is caused by multiple factors, such as industrial dye wastewater. Dye-contaminated water can be treated using hydrogels as adsorbent materials. Recently, composite hydrogels containing metal oxide nanoparticles (MONPs) have been used extensively in wastewater remediation. In this study, we use a statistical and artificial intelligence method, based on principal component analysis (PCA) with different applied parameters, to evaluate the adsorption efficiency of 27 different MONP composite hydrogels for wastewater dye treatment. PCA showed that the hydrogel composites CTS@Fe3O4, PAAm/TiO2, and PEGDMA-rGO/Fe3O4@cellulose should be used in situations involving high pH, time to reach equilibrium, and adsorption capacity. However, as the composites PAAm-co-AAc/TiO2, PVPA/Fe3O4@SiO2, PMOA/ATP/Fe3O4, and PVPA/Fe3O4@SiO2, are preferred when all physical and chemical properties investigated have low magnitudes. To conclude, PCA is a strong method for highlighting the essential factors affecting hydrogel composite selection for dye-contaminated water treatment.
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Huang, Yu-Chao, Pei-Wen Lin, Wen-Jian Qiu, and Ta-I. Yang. "AMPHIPHILIC POLYMER-ASSISTED SYNTHESIS OF HYDROXYAPATITE PARTICLES AND THEIR INFLUENCE ON THE RHEOLOGICAL AND MECHANICAL PROPERTIES OF THERMOSENSITIVE HYDROGELS." Biomedical Engineering: Applications, Basis and Communications 28, no. 02 (April 2016): 1650013. http://dx.doi.org/10.4015/s1016237216500137.

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Polymeric composite materials hold promise for versatile advanced applications. Of utmost importance for these applications is incorporating inorganic particles within polymer matrices which lead to multifunctional polymeric composites with desired functions. Specifically, thermosensitive polymeric hydrogels incorporating particle fillers have elicited widespread interest because of promising applications in drug delivery, tissue engineering, and medical devices. Although these materials are frequently discussed in many research fields, there are no decisive conclusions reported in literature, showing how the particle filler affects the rheological and mechanical behaviors of the resulting hydrogels. In this research, hydroxyapatite (HAp) bioceramics with definable morphologies were synthesized in order to reveal their effects on the resulting properties of HAp/polymer composite hydrogels. HAp particles with spherical, sheet-like and rod-like shapes were prepared with assistance by adding amphiphilic surfactant, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) in synthesis. Thermosensitive composite hydrogels with controllable rheological and mechanical properties were thus developed by incorporating HAp particles into poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) hydrogel. Experimental results revealed that the rheological and mechanical properties of the resultant HAp/PEG-PLGA composite hydrogel not only influenced by the added HAp particle amount, but also by the particle morphology and interactions between particles and hydrogels. The findings from this research provide a critical guideline for designing thermosensitive composite hydrogels with required rheological and mechanical properties.
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Ye, Jing, Gang Yang, Jing Zhang, Zhenghua Xiao, Ling He, Han Zhang, and Qi Liu. "Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering." PeerJ 9 (March 15, 2021): e11022. http://dx.doi.org/10.7717/peerj.11022.

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Background Tissue engineering, which involves the selection of scaffold materials, presents a new therapeutic strategy for damaged tissues or organs. Scaffold design based on blends of proteins and polysaccharides, as mimicry of the native extracellular matrix, has recently become a valuable strategy for tissue engineering. Objective This study aimed to construct composite hydrogels based on natural polymers for tissue engineering. Methods Composite hydrogels based on blends of gelatin with a polysaccharide component (chitosan or alginate) were produced and subsequently enzyme crosslinked. The other three hydrogels, chitosan hydrogel, sodium alginate hydrogel, and microbial transglutaminase-crosslinked gelatin (mTG/GA) hydrogel were also prepared. All hydrogels were evaluated for in vitro degradation property, swelling capacity, and mechanical property. Rat adipose-derived stromal stem cells (ADSCs) were isolated and seeded on (or embedded into) the above-mentioned hydrogels. The morphological features of ADSCs were observed and recorded. The effects of the hydrogels on ADSC survival and adhesion were investigated by immunofluorescence staining. Cell proliferation was tested by thiazolyl blue tetrazolium bromide (MTT) assay. Results Cell viability assay results showed that the five hydrogels are not cytotoxic. The mTG/GA and its composite hydrogels showed higher compressive moduli than the single-component chitosan and alginate hydrogels. MTT assay results showed that ADSCs proliferated better on the composite hydrogels than on the chitosan and alginate hydrogels. Light microscope observation and cell cytoskeleton staining showed that hydrogel strength had obvious effects on cell growth and adhesion. The ADSCs seeded on chitosan and alginate hydrogels plunged into the hydrogels and could not stretch out due to the low strength of the hydrogel, whereas cells seeded on composite hydrogels with higher elastic modulus, could spread out, and grew in size. Conclusion The gelatin-polysaccharide composite hydrogels could serve as attractive biomaterials for tissue engineering due to their easy preparation and favorable biophysical properties.
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Ahmad, Faheem, Bushra Mushtaq, Faaz Ahmed Butt, Muhammad Sohail Zafar, Sheraz Ahmad, Ali Afzal, Yasir Nawab, Abher Rasheed, and Zeynep Ulker. "Synthesis and Characterization of Nonwoven Cotton-Reinforced Cellulose Hydrogel for Wound Dressings." Polymers 13, no. 23 (November 25, 2021): 4098. http://dx.doi.org/10.3390/polym13234098.

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Hydrogels wound dressings have enormous advantages due to their ability to absorb high wound exudate, capacity to load drugs, and provide quick pain relief. The use of hydrogels as wound dressings in their original form is a considerable challenge, as these are difficult to apply on wounds without support. Therefore, the incorporation of polymeric hydrogels with a certain substrate is an emerging field of interest. The present study fabricated cellulose hydrogel using the sol–gel technique and reinforced it with nonwoven cotton for sustainable wound dressing application. The nonwoven cotton was immersed inside the prepared solution of cellulose and heated at 50 °C for 2 h to form cellulose hydrogel–nonwoven cotton composites and characterized for a range of properties. In addition, the prepared hydrogel composite was also loaded with titania particles to attain antibacterial properties. The Fourier transform infrared spectroscopy and scanning electron microscopy confirmed the formation of cellulose hydrogel layers inside the nonwoven cotton structure. The fabricated composite hydrogels showed good moisture management and air permeability, which are essential for comfortable wound healing. The wound exudate testing revealed that the fluid absorptive capacity of cellulose hydrogel nonwoven cotton composite was improved significantly in comparison to pure nonwoven cotton. The results reveal the successful hydrogel formation, having excellent absorbing, antimicrobial, and sustainable properties.
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Pavlyuchenko, V. N., and S. S. Ivanchev. "Composite polymer hydrogels." Polymer Science Series A 51, no. 7 (July 2009): 743–60. http://dx.doi.org/10.1134/s0965545x09070013.

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Ščeglovs, Artemijs, and Kristine Salma-Ancane. "Novel Hydrogels and Composite Hydrogels Based on ԑ-Polylysine, Hyaluronic Acid and Hydroxyapatite." Key Engineering Materials 850 (June 2020): 242–48. http://dx.doi.org/10.4028/www.scientific.net/kem.850.242.

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At this work hydrogel and composite hydrogel systems based on ԑ-polylysine (EPL), hyaluronic acid (HA) and nanocrystalline hydroxyapatite (nHAp) were synthesized via chemical cross-linking method followed by in situ precipitation of nHAp into hydrogel copolymer matrix. Molecular structure, phase composition and morphology of EPL-HA and EPL-HA/nHAp systems were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray powder diffractometry (XRD) and scanning electron microscopy (SEM). The fabricated hydrogels and composite hydrogels were evaluated by hydrogels characteristics such as gel fraction and swelling behavior. This study provides a new insight to develop cutting-edge bioactive hydrogels and composite hydrogels for bone tissue engineering as injectable biomaterials due to beneficial properties of system components.
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Dissertations / Theses on the topic "Composite Hydrogels"

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Kosto, Kimberly Bryan 1977. "Hindered transport in composite hydrogels." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28358.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2004.
Includes bibliographical references (leaves 143-152).
The ultimate goal of this research was to develop a greater understanding of the structural components needed to describe transport within the glomerular basement membrane (GBM). Specifically, dimensionless diffusive and convective hindrance factors were investigated by measuring macromolecular permeability through synthetic, two-fiber, agarose-dextran hydrogels at very small or very high Pe, respectively. By comparing diffusion and convection in the synthetic hydrogel with corresponding measurements in isolated rat GBM, further insight regarding the structure responsible for transport through the GBM was gained. In order to compare diffusive hindrances in the synthetic gels with those in isolated GBM, partitioning in agarose-dextran hydrogels was also examined. Additionally, hindered transport theories were tested. In studying diffusion, partitioning, and convection, macromolecules with Stokes-Einstein radii (r) ranging from 2.7 to 5.9 nm were used. Gels with agarose volume fractions of 0.040 and 0.080 were studied with dextran volume fractions (assuming dextran acts as a fiber) ranging from 0 to 0.0076 and 0 to 0.011, respectively. For the diffusion studies, two globular proteins (ovalbumin and bovine serum albumin) and three narrow fractions of Ficoll, a spherical polysaccharide, were used. For the partitioning and convection studies, four narrow fractions of Ficoll were used. Diffusivities of fluorescein-labeled macromolecules were measured in dilute aqueous solution (D[infinity]), agarose gels (D[alpha]), and agarose-dextran composite gels (D) using fluorescence recovery after photobleaching.
(cont.) For both agarose concentrations, the Darcy permeability (K) decreased by an order of magnitude as the dextran concentration in the gel was increased from zero to its maximum value. For a given gel composition, the relative diffusivity (D/D[infinity]) decreased as r increased, a hallmark of hindered diffusion. For a given test molecule, D/D[infinity] was lowest in the most concentrated gels, as expected. As the dextran concentration was increased to its maximum value, 2-3 fold decreases in relative diffusivity resulted for both agarose gel concentrations. The reductions in macromolecular diffusivities caused by incorporating various amounts of dextran into agarose gels could be predicted fairly accurately from the measured decreases in K, using an effective medium model. This suggests that one might be able to predict diffusivity variations in complex, multicomponent hydrogels (e.g. those in body tissue) in the same manner, provided that values of K can be obtained. Equilibrium partition coefficients ([Phi],the concentration in the gel divided by that in free solution) of fluorescein-labeled Ficolls in pure agarose and agarose-dextran composite gels were measured as a function of gel composition and Ficoll size. As expected, [Phi] generally decreased as the Ficoll size increased (for a given gel composition) or as the amount of dextran incorporated into the gel increased (for a given agarose concentration and Ficoll size). The decrease in [Phi] that accompanied dextran addition was predicted well by an excluded volume theory in which agarose and dextran were both treated as rigid, straight, randomly positioned and oriented fibers ...
by Kimberly Bryan Kosto.
Ph.D.
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Perez, Edward Peña. "Bilayer composite hydrogels for corneal prostheses." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/11786.

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Yang, Xianpeng. "Strong Cellulose Nanofiber Composite Hydrogels via Interface Tailoring." Kyoto University, 2020. http://hdl.handle.net/2433/253333.

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Binti, Adrus Nadia [Verfasser], Mathias [Akademischer Betreuer] Ulbricht, and Christian [Akademischer Betreuer] Mayer. "Stimuli-Responsive Hydrogels and Hydrogel Pore-Filled Composite Membranes / Nadia Adrus. Gutachter: Christian Mayer. Betreuer: Mathias Ulbricht." Duisburg, 2012. http://d-nb.info/1021899720/34.

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Li, Chao. "Synthesis and evaluation of porous composite hydrogels for tissue engineering applications." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1388.

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The purpose of this dissertation was to synthesize and evaluate porous poly(2- hydroxyethyl methacrylate) (PHEMA) and PHEMA composite hydrogels containing various concentrations of titanium dioxide (TiO2) nanoparticles, silicon dioxide (SiO2) nanoparticles, and multi-walled carbon nanotubes (CNTs) for tissue engineering applications. Eighteen PHEMA nanocomposite hydrogels and five control PHEMA hydrogels were prepared in varying concentrations of water (60-90 wt.%) via a free radical polymerization process. Four of these hydrogels were modified further with an OVICOLL®CLEAR collagen, a mixture of type I and type III collagen, for the improvement of cell activities.Gravimetric analysis and X-ray diffraction analysis, as well as scanning electron microscopy (SEM), were used to examine the presence of the nanoadditives contained in the hydrogel polymers. The presence of collagen also was confirmed using a Fourier transform infrared spectroscope, an ultraviolet-visible spectrophotometer and an SEM.All hydrogels appeared opaque and exhibited various porous structures, which then were studied using a SEM. The porous structures were found to be dependent largely on the HEMA:water concentrations in the polymerisation mixtures. There was no significant difference in the porous structure for PHEMA and PHEMA composite hydrogels containing additives. The results from the polymer volume fraction study also indicated the porous structures of the resultant hydrogels.The tensile properties of the hydrogels were examined using a SINTECH200/M material testing workstation. The viscoelastic properties of the hydrogels were investigated using a HAAKE MARS III Modular Advanced Rheometer System. The mechanical properties of the hydrogels, apparently, were affected by the presence of the porous structures. In general, higher tensile and elastic moduli were seen for hydrogels with less porous structures. In contrast, lower tensile and elastic moduli were seen for more porously structured hydrogels. The addition of TiO2 particulates did not show significant influence on tensile and elastic moduli. However, the addition of CNTs increased the viscoelastic moduli of PHEMA hydrogels, which can be attributed to their fibre characteristics. The hydrogels produced in this study have shown a great range of linear viscoelasticity and a quick recovery characteristic, dependent on the macroporous structures and the presence of the TiO2 nanoadditives.The delivery of a model molecule, methylene blue and three biomolecules, including prednisolone 21-hemisuccinate sodium salt, caffeine, and bovine serum albumin were carried out under static and dynamic conditions. Rheological stimulations were used for the dynamic conditions. The delivery of both single and dual molecules was investigated. It was found that increasing the frequency and the shear strain of the stimulations accelerated the relative biomolecule release under dynamic conditions. However, in comparison to the static conditions, the relative delivery of the biomolecules was slowed by the application of rheological stimulations, due to the reabsorption of the biomolecule into the hydrogel matrix under the dynamic conditions. The release profiles of the biomolecules were affected by the concentrations of the biomolecules and their molecular weights, as well as the porous structures of the hydrogels. When dual biomolecules were utilised in the system, the delivery profile of each of the biomolecules was the same as the single biomolecule delivery profile. The relative release also was dependent on the porous structures and the molecular weights.The biomineralisation of the hydrogels was evaluated with a calcification study. The infiltration of the calcium phosphate was found to be more vigorous in a more porously structured hydrogel, and it was significantly enhanced after TiO2 nanoparticles were incorporated. An assay indicated that PHEMA and its nanocomposite hydrogels were tolerated well by the NIH 3T3 fibroblast cells. However, the cell growth on both PHEMA and PHEMA composite hydrogels was relatively slow. The presence of collagen significantly increased numbers of viable cells on modified hydrogels in comparison to that seen on hydrogels containing no collagen molecules. This was true for two other types of cell, including green fluorescent protein-transfected 253 human melanoma cells and human mesenchymal stem cells.In summary, porous PHEMA composite hydrogels make an excellent family of scaffolding materials for soft tissue regeneration. Their porous structures and mechanical properties can be tailor-made, simply by adjusting the chemical composition in the formulae to meet the requirements of specific applications. The bioactivities of the hydrogels also can be improved by tethering natural molecules without altering the porous structure or the mechanical properties. Biomolecules can be preloaded into the hydrogel matrices by a simple diffusion process at room temperature due to the presence of large pores. The preloaded concentrations and the subsequent delivery of these biomolecules can easily be adjusted by changing the concentrations of the stock solutions. This is highly desirable for an ideal tissue scaffold, which not only can provide interconnected pores and dictated mechanical properties, but also is capable of delivering essential signalling biomolecues for the tissue regeneration process. Therefore, these preliminary investigations of PHEMA and PHEMA composite hydrogels have demonstrated their great potential for tissue engineering applications.
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Way, Amanda E. "Stimuli-Responsive Nanofiber Composite Materials: From Functionalized Cellulose Nanocrystals to Guanosine Hydrogels." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1390388160.

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Barnes, Devon. "In vitro bioengineering applications of melt electrowritten and hydrogel composite scaffolds." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212352/1/Devon_Barnes_Thesis.pdf.

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Two-dimensional cell cultures provide an inaccurate representation of how cells develop and are affected by disease and injury. Scaffold-based tissue engineering techniques that combine novel biomaterials and printing methods could assist in the design of more physiologically relevant, three-dimensional experimental tissue models. This thesis investigated the application of carbohydrate glass as a sacrificial material toward producing perfusable hydrogel devices using melt electrowriting, the development and optimisation of a three-dimensional bioengineered bone marrow microenvironment, and a literature review of the approaches toward the development, imaging and analysis of resulting three-dimensional models.
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Barros, Manuel João Salazar Guedes de. "Fabrication of hydrogel-bioactive glass composite scaffolds for bone tissue engineering." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17461.

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Mestrado em Materiais e Dispositivos Biomédicos
Bone is an extremely important connective tissue in the human body, as it provides support and protection of internal organs, being also metabolically relevant as the main mineral reservoir and assuring haematopoiesis through the bone marrow. Due to the current ageing of the population, an increase in bone tissue related diseases is noticeable. Thus, more efficient therapies for treating bone diseases is crucial. Tissue Engineering appears as a promising technology for treating several of those problems, such as bone loss and joint problems. In the present work, composite biomaterials composed of a polymeric hydrogel matrix reinforced with bioactive glass particles were prepared. Individually, these materials have a high water content, which enhances their diffusive transport properties, and display osteogenic properties, respectively. The selected polymer was RGD functionalized pectin, due to its interesting properties, such as biocompatibility, cell-adhesive characteristics and adequacy for cell entrapment, and the bioactive glass selected was a novel alkali-free formulation of 70% diopside and 30% tricalcium phosphate (Di-70), composed of SiO2, CaO, MgO and P2O5. Several different composite formulations were tested, in which pectin concentration, bioactive glass content and glass particle size were varied. The biocomposite’s viscoelastic properties were assessed, as well as their biological behaviour through cytotoxicity assays, and osteogenic character by incubating mesenchymal stem cell (MSC)-laden composites into both basal and osteogenic media for up to 21 days. The results obtained demonstrated that a composite biomaterial with tuneable mechanical properties was successfully prepared, with in situ crosslinking ability within therapeutically relevant timeframes, and not requiring additional crosslinking strategies besides its own composition. Furthermore, its intrinsic osteogenic properties due to the glass composition provided the adequate conditions for promoting the differentiation of MSCs without osteogenic stimulation. The combined properties achieved indicate that the biocomposites prepared are suitable candidate cellularized biomaterials for bone tissue engineering applications.
O osso é um tecido conjuntivo de extrema importância no organismo humano, tendo funções como suporte ou proteção de órgãos internos, sendo também metabolicamente relevante como o principal reservatório de minerais e assegurando a hematopoiese com a medula óssea. Dado o envelhecimento da população, tem-se verificado um aumento da incidência de doenças degenerativas deste tecido, sendo assim essencial aplicar terapias altamente eficientes para o tratamento dessas patologias. A Engenharia de Tecidos surge como uma tecnologia promissora no tratamento destes problemas, como a perda de massa óssea e problemas nas articulações. Neste trabalho, foram produzidos biomateriais compósitos, baseados numa matriz polimérica sob a forma de hidrogel reforçada com partículas de vidro bioativo. Individualmente, estes materiais apresentam um elevado teor em água favorável ao transporte de nutrientes, e propriedades osteogénicas, respetivamente. O polímero selecionado foi a pectina funcionalizada com RGD, dadas as suas propriedades interessantes como a biocompatibilidade, capacidade de promover a adesão celular e adequabilidade para o encapsulamento de células, e o vidro bioativo apresenta uma composição de 70% de diópsido e 30% de fosfato tricálcico (Di-70) isento de alcalinos e sendo composto por SiO2, CaO, MgO e P2O5. Diferentes formulações de hidrogéis compósitos foram testadas, em que se variou a concentração de polímero, a concentração de biovidro e o seu tamanho de partícula. Analisaram-se as propriedades viscoelásticas dos biocompósitos, bem como o seu comportamento biológico, com ensaios de citotoxicidade, e ainda as propriedades osteogénicas do material, pela incubação de hidrogéis contendo células estaminais mesenquimais (MSCs) em meio basal e osteogénico durante 21 dias. Os resultados deste trabalho indicam que foi possível preparar um biomaterial compósito de propriedades mecânicas ajustáveis, com capacidade de reticular in situ em tempos clinicamente desejáveis sem necessitar agentes reticulantes externos. Para além disso, as propriedades osteogénicas intrínsecas do biovidro forneceram as condições adequadas para a promoção da diferenciação de MSCs sem estimulação osteogénica adicional. As propriedades combinadas alcançadas indicam que os biocompósitos preparados têm potencial para ser aplicados em engenharia de tecido ósseo.
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Tay, Pei Kun Richie. "Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78244.

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Thesis (S.M.)--Harvard-MIT Program in Health Sciences and Technology, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 27-30).
Composite hydrogels find increasing use as biomaterials because the addition of a filler often improves on the material properties of the original matrix, or provides new optical, magnetic, conductive or bioactive functionalities not inherent to the hydrogel. In this work we synthesized nanocomposite gelatin methacrylate (GelMA) hydrogels that incorporate D,L-cyclic peptide nanotubes. These nanotubes are biocompatible, stiff and their physical and chemical properties can be tailored simply by changing the amino acid sequence of the peptide. We show that the nanotubes successfully integrated into the hydrogel matrix and provided some mechanical reinforcement, without affecting hydrogel porosity or hydration characteristics. We will be using this composite system as a platform for engineering hydrogels with unique physical and biological properties to the hydrogel, for application as biological scaffolds.
by Pei Kun Richie Tay.
S.M.
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Ehrenhofer, Adrian, and Thomas Wallmersperger. "Active hydrogel composite membranes for the analysis of cell size distributions." SPIE, 2019. https://tud.qucosa.de/id/qucosa%3A74237.

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Active membranes with switchable pores that are based on hydrogels can be used to measure the cell size distribution in blood samples. The system investigated in the present research is based on a polyethylene terephthalate (PET) membrane that is surface polymerized with poly (N-isopropyl acrylamide) (PNiPAAm) to form active pores of arbitrary geometry. The PET membrane provides the functionality of a backbone for mechanical rigidity, while the soft PNiPAAm hydrogel forms the active pores. Modeling and simulation of the active hydrogel behavior proved to adequately predict the opening and closing of the pores under application of an activating stimulus, e.g. temperature. The applied model is called Temperature-Expansion-Model and uses the analogy of thermal expansion to model the volume swelling of hydrogels. The Normalized Extended Temperature-Expansion-Model can englobe arbitrary hydrogels and large geometric displacements. Studies of pore opening - performed by using commercial finite element tools - show good agreement of the experimentally measured shape change of active pores. Based on these studies, the particulate fluid flow through the switchable pores is analyzed. Through application of a membrane process, i.e. a given variation of applied pressure and switching stimulus for the hydrogel, the size profile of the blocking particles can be measured directly using the flux difference under constant pressure. This allows the measurement of the cell size distribution in blood samples, e.g. to detect circulating tumor cells or anomalies in the distribution that hint to anemia.
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Books on the topic "Composite Hydrogels"

1

H, Jones Russell, Ricker Richard E, Minerals, Metals and Materials Society., ASM International. Materials Science Division., and Conference on Environmental Effects on Advanced Materials., eds. Environmental effects on advanced materials. Warrendale, Pa: Minerals, Metals & Materials Society, 1991.

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Takahira, Kamigaki, Kubota Etsuo, and United States. National Aeronautics and Space Administration., eds. Electrically conducting polymer-copper sulphide composite films, preparation by treatment of polymer-copper (II) acetate composites with hydrogen sulphide. Washington, DC: National Aeronautics and Space Administration, 1988.

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United States. National Aeronautics and Space Administration., ed. Trade study plan for reusable hydrogen composite tank system (RHCTS). [Downey, Calif.]: Rockwell Aerospace, Space Systems Division, 1994.

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United States. National Aeronautics and Space Administration., ed. Structural arrangement trade study: Reusable hydrogen composite tank system and graphite composite primary structures (GCPS) : executive summary. [Washington, DC: National Aeronautics and Space Administration, 1995.

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United States. National Aeronautics and Space Administration., ed. Selection process for trade study: Reusable hydrogen composite tank system (RHCTS). [Downey, Calif.]: Rockwell Aerospace, Space Systems Division, 1994.

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United States. National Aeronautics and Space Administration., ed. Addendum to structural arrangement trade study: Reusable hydrogen composite tank system (RHCTS) and graphite composite primary structures (GCPS). [Washington, DC: National Aeronautics and Space Administration, 1995.

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E, Lake R., Wilkerson C, and George C. Marshall Space Flight Center., eds. Unlined reusable filament wound composite cryogenic tank testing. [Marshall Space Flight Center, Ala.]: National Aeronautics and Space Administration, Marshall Space Flight Center, 1999.

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E, Lake R., Wilkerson C, and George C. Marshall Space Flight Center., eds. Unlined reusable filament wound composite cryogenic tank testing. [Marshall Space Flight Center, Ala.]: National Aeronautics and Space Administration, Marshall Space Flight Center, 1999.

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Fukassei ketsugō, fukassei bunshi no kasseika: Kakushinteki na bunshi henkan hannō no kaitaku = Bond activation and molecular activation. Kyōto-shi: Kagaku Dōjin, 2011.

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George C. Marshall Space Flight Center., ed. Acoustic emission monitoring of the DC-XA composite liquid hydrogen tank during structural testing. MSFC, Ala: National Aeronautics and Space Administration, Marshall Space Flight Center, 1996.

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Book chapters on the topic "Composite Hydrogels"

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Kawaguchi, Haruma. "Stimuli-Sensitive Composite Microgels." In Hydrogels, 141–56. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-1104-5_12.

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Meid, Judith, Swen Lehmann, and Walter Richtering. "Temperature-Sensitive Composite Hydrogels: Coupling Between Gel Matrix and Embedded Nano- and Microgels." In Intelligent Hydrogels, 91–100. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01683-2_8.

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Ambrosio, L., R. De Santis, and L. Nicolais. "Composite Hydrogels as Intervertebral Disc Prostheses." In Science and Technology of Polymers and Advanced Materials, 547–55. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0112-5_46.

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Rebecca, P. N. Blessy, D. Durgalakshmi, and R. Ajay Rakkesh. "Composite Hydrogels for Adipose Tissue Engineering." In Functional Biomaterials, 255–74. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003251767-12.

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Gull, Nafisa, Shahzad Maqsood Khan, Atif Islam, and Muhammad Taqi Zahid Butt. "Hydrogels used for Biomedical Applications." In Bio Monomers for Green Polymeric Composite Materials, 175–99. Chichester, UK: John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781119301714.ch9.

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Padmanabhan, Aiswaria, and Lakshmi S. Nair. "Chitosan Hydrogels for Regenerative Engineering." In Springer Series on Polymer and Composite Materials, 3–40. New Delhi: Springer India, 2015. http://dx.doi.org/10.1007/978-81-322-2511-9_1.

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Guarino, V., A. Gloria, R. De Santis, and L. Ambrosio. "Composite Hydrogels for Scaffold Design, Tissue Engineering, and Prostheses." In Biomedical Applications of Hydrogels Handbook, 227–45. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-5919-5_12.

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Sharma, Kashma, Vijay Kumar, B. S. Kaith, Susheel Kalia, and Hendrik C. Swart. "Conducting Polymer Hydrogels and Their Applications." In Springer Series on Polymer and Composite Materials, 193–221. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46458-9_7.

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Nille, Omkar S., Akshay S. Patil, Govind B. Kolekar, and Anil H. Gore. "Carbon-Based Composite Hydrogels for Environmental Remediation." In Environmental Remediation Through Carbon Based Nano Composites, 427–43. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6699-8_20.

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Ribeiro, Andreza Maria, and Ivan Antonio Neumann. "Advances in Composite Hydrogels for Ocular Drug Delivery and Biomedical Engineering Application." In Functional Hydrogels in Drug Delivery, 303–26. Boca Raton, FL : CRC Press/ Taylor & Francis Group, 2017.: CRC Press, 2017. http://dx.doi.org/10.4324/9781315152271-11.

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Conference papers on the topic "Composite Hydrogels"

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Chobit, Maksym, Yuriy Panchenko, and Victor Vasylyev. "The Investigation of Hydrogels Composite Filling by Gelatin." In Chemical technology and engineering. Lviv Polytechnic National University, 2019. http://dx.doi.org/10.23939/cte2019.01.133.

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Pholpabu, Pitirat, Pattira Somharnwong, Nattathida Huaybun, Chanatip Cherdbaramee, Vichapas Boonpasart, Lakkhanabut Komchum, and Achiya Phuengsap. "Controlled Release of Dual Antibacterial Drug from Composite Hydrogels." In 2019 12th Biomedical Engineering International Conference (BMEiCON). IEEE, 2019. http://dx.doi.org/10.1109/bmeicon47515.2019.8990291.

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Obra, Johndel, James Quin Maranan, Denise Faye Lensoco, and Terence Tumolva. "Synthesis and Characterization of NaCMC/HEC/ Activated Carbon Hydrogel Composites for the Desalination of Seawater." In 7th GoGreen Summit 2021. Technoarete, 2021. http://dx.doi.org/10.36647/978-93-92106-02-6.16.

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Current available methods for water desalination are energy intensive, expensive, and not feasible for small-scale applications. As an alternative, hydrogels and hydrogel composites may be utilized both as draw agent and semi-permeable membrane to desalinate water via forward osmosis. In this study, a non-toxic, biodegradable, and low-cost hydrogel composite is prepared by adding activated carbon (AC) as filler to a 3:1 blend of sodium carboxymethyl cellulose (NaCMC) and hydroxyethyl cellulose (HEC), with citric acid as crosslinking agent. A one factor-at-a-time (OFAT) analysis was performed to correlate the crosslinker concentration, crosslinking duration, and AC content to the swelling and desalination efficiency of the CMC/HEC/AC hydrogel composite. Results showed that the swelling of the hydrogel varies directly with the crosslinking duration but varies inversely with the crosslinking concentration. The experiments also showed that the addition of AC as filler significantly improves the desalination efficiency of the hydrogel composite; however, it was also observed that efficiency is reduced if the AC content is excessive.
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Marks, William H., Sze C. Yang, George W. Dombi, and Sujata K. Bhatia. "Carbon Nanobrushes Embedded Within Hydrogel Composites for Tissue Engineering." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93122.

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The objective of this work is to study the effect of carbon nanobrushes embedded within hydrogel composites on tissue engineering. The carbon nanobrushes, providing electrical conductivity to the hydrogels, influence the growth and proliferation of clinically relevant cell lines within the hydrogel composite. The composite is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to support the growth of tissue by studying fibroblasts and myoctes, which serve as indicators on the feasibility of this platform eventually serving as a matrix to stimulate wound closure and repair injured tissue. In such a model, fibroblasts and myocytes are seeded separately on the composite hydrogel and bathed in culture medium. The experimental model assesses the ability of fibroblasts and myocytes to grow into and adhere to the gel containing carbon nanobrushes. The work demonstrates that carbon nanobrushes can be dispersed within poloxamer gels, and that fibroblasts and myoctyes can proliferate within a poloxamer gel containing homogenously dispersed carbon nanobrushes. The work also examines the role of the carbon nanobrushes in altering the physical properties of the hydrogel composite. This work has relevance for tissue engineering and tissue regeneration in clinical medicine, with a focus on utilizing biomimetic and bioinspired materials, like the carbon nanobrushes, to enhance growth capabilities.
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Chang, Wei-Jen, Nadeen Chahine, and Pen-Hsiu Grace Chao. "Effects of Composite Substrate Microstructure on Fibroblast Morphology and Migration." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53859.

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Many studies have focused on the effects of substrate rigidity on cell traction, migration, and differentiation [1–3]. Most cells are known to migrate toward the stiffer substrate, a phenomenon known as durotaxis. Recent reports have also demonstrated the ‘depth-sensing’ ability of cells on soft hydrogels where cell behaviors on thin gels are more similar to those on stiffer substrates [4–5]. Taking advantage of the high fidelity of microfabrication and soft lithography products, we created novel composite substrates composed of a top layer of collagen hydrogel and an underlying microstructure of silicon elastomer. We hypothesize that cells can sense the underlying microstructures and regulate cell translocation and morphology accordingly.
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Brahim, Sean I., Gymama E. Slaughter, and Anthony Guiseppi-Elie. "Electrical and electrochemical characterization of electroconductive PPy-p(HEMA) composite hydrogels." In Smart Structures and Materials, edited by Dimitris C. Lagoudas. SPIE, 2003. http://dx.doi.org/10.1117/12.484748.

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Valchanov, Petar, Stoyan Pavlov, and Trifon Chervenkov. "Composite hydrogels and their application for 3D Bioprinting in the Regenerative medicine." In 2020 International Conference on Biomedical Innovations and Applications (BIA). IEEE, 2020. http://dx.doi.org/10.1109/bia50171.2020.9244494.

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Sringam, Jiradet, Tatiya Trongsatitkul, and Nitinat Suppakarn. "Effects of borax and montmorillonite contents on mechanical properties of cassava btarch-based composite hydrogels." In THE SECOND MATERIALS RESEARCH SOCIETY OF THAILAND INTERNATIONAL CONFERENCE. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0022969.

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Oprita, Elena Iulia, Oana Craciunescu, Orsolya C. Fazakas-Raduly, Reka Barabas, Teodora Ciucan, Ana Maria Seciu-Grama, and Anca Oancea. "Novel Composite Hydrogels Based on Natural Components and Akermanite Enriched with Icariin for Osteochondral Healing." In Priochem 2021. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/chemproc2022007063.

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Chandkoti, Ikhlas, Amol Naikwadi, and Manoj Mali. "Moisture Condensation Management in Automotive Headlamp Using Super Hydrophilic Cross-Linked Polymer Composites." In Symposium on International Automotive Technology. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2024. http://dx.doi.org/10.4271/2024-26-0084.

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<div class="section abstract"><div class="htmlview paragraph">This work aims to develop potential super hydrophilic cross-linked smart polymer composites and condensation management device (CMD) for condensation control in automotive headlamps. Condensation and moisture buildup in the automotive headlamp decrease the visibility to the driver. The super hydrophilic cross-linked polymer composites were prepared with the combination of polyacrylamide-based hydrogels and hygroscopic lithium bromide desiccants. In this work, we have utilized various desiccants such as calcium chloride (Desiccant-1), silica gel (Desiccant-2) and lithium bromide (Desiccant-3) which is blended together with the polyacrylamide-based hydrogel. The prepared various compositional smart materials have been analyzed for structural, morphological, thermal and functional properties using fourier transform infrared spectroscopy (FTIR), optical microscopy (POM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimeter (DSC) and water uptake capacity. The developed super hydrophilic cross-linked polymer composites were kept into the designed condensation device and placed into the headlamp assembly. The effective composite composition showed 70-80 % water absorption after 24 h. The various composition of the composites was prepared and experiment were carried out. By using 50-70 % of super moisture absorber material into the polymer matrix higher rate of water absorption is achieved. The prepared super hydrophilic cross-linked polymer composites showed potential water absorption which can be useful for condensation management in headlamps.</div></div>
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Reports on the topic "Composite Hydrogels"

1

Ruckman, M. W., H. Wiesmann, M. Strongin, K. Young, and M. Fetcenko. Composite Metal-hydrogen Electrodes for Metal-Hydrogen Batteries. Office of Scientific and Technical Information (OSTI), April 1997. http://dx.doi.org/10.2172/770461.

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Li, Yuzhan, Vera Bocharova, Seung Pyo Jeong, Navin Kumar, Som Shrestha, Kyle Gluesenkamp, and Diana Hun. Fabrication of New PCM Hydrogel Composites. Office of Scientific and Technical Information (OSTI), April 2021. http://dx.doi.org/10.2172/1779119.

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Fort, III, William C., Richard A. Kallman, Miguel Maes, Edward G. Skolnik, and Steven C. Weiner. Safety Evaluation Report: Development of Improved Composite Pressure Vessels for Hydrogen Storage, Lincoln Composites, Lincoln, NE, May 25, 2010. Office of Scientific and Technical Information (OSTI), December 2010. http://dx.doi.org/10.2172/1122334.

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Livingston, R. R. Test Plan for Composite Hydrogen Getter Materials. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/767285.

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Newhouse, Norman L. Development of Improved Composite Pressure Vessels for Hydrogen Storage. Office of Scientific and Technical Information (OSTI), April 2016. http://dx.doi.org/10.2172/1249338.

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J. Douglas Way and Paul M. Thoen. Palladium/Copper Alloy Composite Membranes for High Temperature Hydrogen Separation. US: Trustees Of The Colorado School Of Mines, August 2006. http://dx.doi.org/10.2172/898816.

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Ilias, S., F. G. King, N. Su, and U. I. Udo-Aka. Separation of hydrogen using thin film palladium-ceramic composite membrane. Office of Scientific and Technical Information (OSTI), November 1995. http://dx.doi.org/10.2172/128538.

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J. Douglas Way. PALLADIUM/COPPER ALLOY COMPOSITE MEMBRANES FOR HIGH TEMPERATURE HYDROGEN SEPARATION. Office of Scientific and Technical Information (OSTI), August 2004. http://dx.doi.org/10.2172/835876.

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J. Douglas Way and Paul M. Thoen. Palladium/Copper Alloy Composite Membranes for High Temperature Hydrogen Separation. Office of Scientific and Technical Information (OSTI), August 2005. http://dx.doi.org/10.2172/860440.

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Morris Argyle, John Ackerman, Suresh Muknahallipatna, Jerry Hamann, Stanislaw Legowski, Gui-Bing Zhao, Sanil John, Ji-Jun Zhang, and Linna Wang. Novel Composite Hydrogen-Permeable Membranes for Nonthermal Plasma Reactors for the Decomposition of Hydrogen Sulfide. Office of Scientific and Technical Information (OSTI), September 2007. http://dx.doi.org/10.2172/941661.

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