Dissertations / Theses on the topic 'Component isolation'
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Goonasekera, Nuwan Abhayawardena. "Program-level support for protecting an application from untrustworthy components." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/60851/1/Nuwan_Goonasekera_Thesis.pdf.
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Many software applications extend their functionality by dynamically loading executable components into their allocated address space. Such components, exemplified by browser plugins and other software add-ons, not only enable reusability, but also promote programming simplicity, as they reside in the same address space as their host application, supporting easy sharing of complex data structures and pointers.
However, such components are also often of unknown provenance and quality and may be riddled with accidental bugs or, in some cases, deliberately malicious code.
Statistics show that such component failures account for a high percentage of software crashes and vulnerabilities. Enabling isolation of such fine-grained components is therefore necessary to increase the stability, security and resilience of computer programs.
This thesis addresses this issue by showing how host applications can create isolation domains for individual components, while preserving the benefits of a single address space, via a new architecture for software isolation called LibVM. Towards this end, we define a specification which outlines the functional requirements for LibVM, identify the conditions under which these functional requirements can be met, define an abstract Application Programming Interface (API) that encompasses the general problem of isolating shared libraries, thus separating policy from mechanism, and prove its practicality with two concrete implementations based on hardware virtualization and system call interpositioning, respectively. The results demonstrate that hardware isolation minimises the difficulties encountered with software based approaches, while also reducing the size of the trusted computing base, thus increasing confidence in the solution’s correctness.
This thesis concludes that, not only is it feasible to create such isolation domains for individual components, but that it should also be a fundamental operating system supported abstraction, which would lead to more stable and secure applications.
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Lin, Zhefeng. "Isolation and analysis of TCTR2, a tomato gene related to the ethylene signalling component CTR1." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312236.
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Ochei, Laud Charles. "Architecting the deployment of cloud-hosted services for guaranteeing multitenancy isolation." Thesis, Robert Gordon University, 2017. http://hdl.handle.net/10059/2448.
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In recent years, software tools used for Global Software Development (GSD) processes (e.g., continuous integration, version control and bug tracking) are increasingly being deployed in the cloud to serve multiple users. Multitenancy is an important architectural property in cloud computing in which a single instance of an application is used to serve multiple users. There are two key challenges of implementing multitenancy: (i) ensuring isolation either between multiple tenants accessing the service or components designed (or integrated) with the service; and (ii) resolving trade-offs between varying degrees of isolation between tenants or components. The aim of this thesis is to investigate how to architect the deployment of cloud-hosted service while guaranteeing the required degree of multitenancy isolation. Existing approaches for architecting the deployment of cloud-hosted services to serve multiple users have paid little attention to evaluating the effect of the varying degrees of multitenancy isolation on the required performance, resource consumption and access privilege of tenants (or components). Approaches for isolating tenants (or components) are usually implemented at lower layers of the cloud stack and often apply to the entire system and not to individual tenants (or components). This thesis adopts a multimethod research strategy to providing a set of novel approaches for addressing these problems. Firstly, a taxonomy of deployment patterns and a general process, CLIP (CLoud-based Identification process for deployment Patterns) was developed for guiding architects in selecting applicable cloud deployment patterns (together with the supporting technologies) using the taxonomy for deploying services to the cloud. Secondly, an approach named COMITRE (COmponent-based approach to Multitenancy Isolation Through request RE-routing) was developed together with supporting algorithms and then applied to three case studies to empirically evaluate the varying degrees of isolation between tenants enabled by multitenancy patterns for three different cloud-hosted GSD processes, namely-continuous integration, version control, and bug tracking. After that, a synthesis of findings from the three case studies was carried out to provide an explanatory framework and new insights about varying degrees of multitenancy isolation. Thirdly, a model-based decision support system together with four variants of a metaheuristic solution was developed for solving the model to provide an optimal solution for deploying components of a cloud-hosted application with guarantees for multitenancy isolation. By creating and applying the taxonomy, it was learnt that most deployment patterns are related and can be implemented by combining with others, for example, in hybrid deployment scenarios to integrate data residing in multiple clouds. It has been argued that the shared component is better for reducing resource consumption while the dedicated component is better in avoiding performance interference. However, as the experimental results show, there are certain GSD processes where that might not necessarily be so, for example, in version control, where additional copies of the files are created in the repository, thus consuming more disk space. Over time, performance begins to degrade as more time is spent searching across many files on the disk. Extensive performance evaluation of the model-based decision support system showed that the optimal solutions obtained had low variability and percent deviation, and were produced with low computational effort when compared to a given target solution.
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Huang, Bing-Quan. "Isolation and characterization of embryo sacs and their component cells in a synergidless (Plumbago) and a synergid-bearing (Nicotiana) angiosperm /." Full-text version available from OU Domain via ProQuest Digital Dissertations, 1991.
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Dastoor, Farahad. "Isolation and regulation of expression of the Rhodobacter capsulatus suca gene encoding the E1o component of the α-ketoglutarate dehydrogenase enzyme complex." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29805.
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The citric acid cycle (CAC) is an extremely wide-spread metabolic pathway involved in energy production and intermediary metabolism.
One of the key enzymes of the CAC is the α-ketoglutarate dehydrogenase (KGD) enzyme complex. In facultative bacteria, activity of the KGD enzyme complex appears to vary in keeping with the primary function of the CAC, in response to growth conditions (energy production or biosynthesis). Therefore, under anaerobic conditions synthesis of the KGD enzyme complex is repressed in some species and carbon flow through some CAC steps is reversed converting the CAC into a branched pathway that functions primarily with intermediary metabolism.
The purple photo synthetic bacterium Rhodobacter capsulatus relies on the CAC for energy production under aerobic growth conditions on minimal media containing organic acids such as malate, succinate, and pyruvate. However, when growing under anaerobic photo synthetic conditions R. capsulatus produces energy by photosynthesis, although intermediates of the CAC are still required for the biosynthesis of bacteriochlorophyll and amino acids. It is believed that R. capsulatus does not operate an anaerobic branched version of the CAC, as in other facultative bacteria, but a less active cyclic one. Therefore, it is of great interest to understand the mechanism by which KGD enzyme activity is regulated and how this affects the operation of the CAC in R. capsulatus in response to fluctuating environmental conditions.
I have isolated the R. capsulatus sucA gene encoding the E1o enzyme component of the KGD enzyme complex. Pulse labelling of R. capsulatus cultures growing aerobically and photosynthetically indicated that the sucA gene was transcribed at a higher level under aerobic growth conditions than under photosynthetic growth conditions. This increased
level of transcription resulted in a 7-fold increase in the steady state levels of KGD mRNA, and a 9 to 13-fold increase in KGD enzyme specific activity in crude cell extracts under aerobic growth conditions, compared to anaerobic photosynthetic growth conditions. This regulation of the sucA gene in response to oxygen is different from any other R. capsulatus gene studied, and is probably part of a larger network of processes that takes place to regulate control of metabolic pathways in cells that shift between two environmental conditions.Science, Faculty of
Microbiology and Immunology, Department of
Graduate
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Santos, da Gama Kiev. "Vers les applications fiables basées sur des composants dynamiques." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00633320.
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Les logiciels s'orientent de plus en plus vers des architectures évolutives, capables de s'adapter facilement aux changements et d'intégrer de nouvelles fonctionnalités. Ceci est important pour plusieurs classes d'applications qui ont besoin d'évoluer sans que cela implique d'interrompre leur exécution. Des plateformes dynamiques à composants autorisent ce type d'évolution à l'exécution, en permettant aux composants d'être chargés et exécutés sans requérir le redémarrage complet de l'application en service. Toutefois, la flexibilité d'un tel mécanisme introduit de nouveaux défis qui exigent de gérer les possibles erreurs dues à des incohérences dans le processus de mise à jour, ou en raison du comportement défectueux de composants survenant pendant l'exécution de l'application. Des composants tiers dont l'origine ou la qualité sont inconnus peuvent être considérées à priori comme peu fiables, car ils peuvent potentiellement introduire des défauts d'applications lorsqu'il est combiné avec d'autres composants. Nous sommes intéressés à la réduction de l'impact de ces composants considérés comme non fiables et qui sont susceptibles de compromettre la fiabilité de l'application en cours d'exécution. Cette thèse porte sur l'application de techniques pour améliorer la fiabilité des applications dynamiques à composants. Pour cela, nous proposons l'utilisation des frontières d'isolation pouvant fournir du contingentement de fautes. Le composant ainsi isolé ne perturbe pas le reste de l'application quand il est défaillant. Une telle approche peut être vu sous trois perspectives présentées: (i) l'isolement des composants dynamiques, régi par une politique d'exécution reconfigurable, (ii) l'autoréparation de conteneurs d'isolement, et (iii) l'utilisation des aspects pour séparer les préoccupations de fiabilité à partir du code fonctionnel.
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Razanau, Aleh [Verfasser], and N. F. [Akademischer Betreuer] Käufer. "Isolation and characterization of suppressors of the prp1 gene, encoding a regulatory component of the pre-catalytic spliceosome in fission yeast / Aleh Razanau ; Betreuer: N. F. Käufer." Braunschweig : Technische Universität Braunschweig, 2010. http://d-nb.info/1175826820/34.
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DeSilva, Veronica. "Selenium redox cycling isolation and characterization of a stimulatory component from tissue of loblolly pine for multiplication of somatic embryos; development of an assay to measure l-phenylalanine concentration in blood plasma /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/29788.
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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.Committee Chair: Sheldon May; Committee Members: Nicholas Hud, Stanley Pollock, James Powers, and Gerald Pullman. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Pierre, Allyn Grey de Almeida Lima. "Transações reconfiguráveis para o ambiente móvel." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/275807.
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Orientador: Maria Beatriz Felgar de ToledoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Computação
Made available in DSpace on 2018-08-16T08:41:15Z (GMT). No. of bitstreams: 1 Pierre_AllynGreydeAlmeidaLima_M.pdf: 1760009 bytes, checksum: 4af51767131cfa3c30ee8f7ea8830949 (MD5) Previous issue date: 2009
Resumo: Dentre as tecnologias emergentes, a computação móvel tem a sua posição de destaque. Os dispositivos móveis estão mais presentes na vida das pessoas e contendo aplicações mais sofisticadas e semelhantes às executadas em computadores pessoais. Num mundo globalizado, onde o tempo é escasso e valioso, os dispositivos móveis mantêm as pessoas em contato com informações e atividades que elas desejam enquanto elas estão em movimento. Um exemplo recente é aumento do uso da internet em celulares, permitindo que os usuários acessem diversos tipos de aplicações, tendo grande parte delas interação com bancos de dados. Apesar de atrativa, a computação móvel traz desafios ao desenvolvedor, pois ele deve considerar os recursos limitados tais como largura de banda, conectividade e o alto custo da obtenção de dados. Nesse contexto, as transações representam um importante papel de garantir que o dinamismo do ambiente da computação móvel não comprometa a confiabilidade das aplicações. Porém, algumas aplicações não podem ser implementadas considerando o modelo de transações tradicional, pois elas têm um tempo mais longo de duração do que aquelas convencionalmente modeladas. Sendo assim, as configurações de uma transação realizadas no início de sua execução podem deixar de ser adequadas no decorrer da sua execução, devido às mudanças no ambiente. Diversos modelos de transações têm sido apresentados na literatura para atender a esse ambiente. Apesar de muitas idéias interessantes e relevantes, alguns modelos não permitem que a adaptação diante da variação dos recursos seja realizada durante a execução de uma transação e quando permitem, eles realizam grandes reconfigurações arquiteturais. Motivada por essas questões, essa dissertação propõe transações reconfiguráveis, isto é, a configuração dinâmica de mecanismos transacionais antes do início da transação e a reconfiguração de propriedades transacionais durante sua execução. Para que a reconfiguração dinâmica fosse realizada, um modelo de componentes chamado OpenCOM foi utilizado na arquitetura proposta, por este ser reflexivo, leve e independente de plataforma. O nível de isolamento é a propriedade transacional que poderá ser reconfigurada durante a transação e o controle de concorrência é o mecanismo que garantirá o isolamento entre as transações e poderá ser configurado antes do início da transação. A configuração do controle de concorrência é uma contribuição inovadora dessa dissertação, pois em muitos trabalhos existentes não é possível a configuração desse mecanismo transacional. A fim de validar a arquitetura proposta, um protótipo de um sistema de vendas foi desenvolvido. Através dessa implementação foi possível analisar os impactos da reconfiguração durante uma transação
Abstract: Among the emerging technologies, mobile computing has its position of prominence. Mobile devices are more present in people's lives and with more sophisticated applications similar to those implemented in personal computers. In a globalized world where time is scarce and of great importance, mobile devices keep people in touch with information and activities they want while they are moving. A recent example is the increasing use of the Internet on mobile phones allowing users to access various types of applications and much of them interacting with databases. Although attractive, the mobile computing brings challenges to the developer because he must consider the limited resources such as bandwidth, connectivity and the high cost of obtaining data. In this context, the transactions represent an important role to ensure that the dynamic environment of mobile computing does not compromise the reliability of applications. However some applications cannot be implemented given the traditional transactions models because they have a longer duration than those conventionally shaped. Therefore the settings of a transaction carried out before its execution may not be appropriate during the execution due to changes in the environment. Various transactions models have been reported in the literature to serve this environment. Although having many interesting and relevant ideas, some models do not allow the adaptation in the face of change of resources during the execution of a transaction and when this is allowed, they require many transactional reconfigurations. Motivated by these issues, this dissertation proposes reconfigurable transactions that are the dynamic configuration of transactional mechanisms before the beginning of the transaction and the reconfiguration of transactional properties during its execution. For dynamic reconfiguration, a component model called OpenCOM has been used in the proposed architecture because it is reflective, lightweight and platform-independent. The isolation level is the property that may be reconfigured during the transaction and the concurrency control is the mechanism that ensures the isolation between the transactions and it can be configured before the beginning of transaction. The configuration of concurrency control is an original contribution of this dissertation because many works do not allow the configuration of this transactional mechanism. In order to validate the proposed architecture, a prototype of a sales system has been developed. Through this implementation it was possible to analyze the impacts of the reconfiguration during a transaction
Mestrado
Sistemas Distribuidos
Mestre em Ciência da Computação
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Xu, Yue, of Western Sydney Hawkesbury University, of Science Technology and Agriculture Faculty, and School of Food Science. "Isolation and characterization of components from whey." THESIS_FSTA_SFS_Xu_Y.xml, 1996. http://handle.uws.edu.au:8081/1959.7/248.
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The structure, functionality, isolation methods and applications of whey components, particularly the proteins and lactose, have been extensively studied. These studies have had a great impact on the food industry where whey components are increasingly being used as food ingredients. Two generations of whey protein product, namely Lactalbumin, produced by heat-induced precipitation, and Whey Protein Concentration/ Isloate, produced by ultrafiltration/ ion exchange chromatography, have been commercialised. Crystalline lactose in the food and pharmaceutical grades is also being produced. Recently, research activities in whey fractionation have shifted to the isolation of the minor components. This thesis is aimed at developing a Total Whey Utilization strategy by which the several components of the whey stream would be completely recovered by fractionation, resulting in little or no residue to be disposed of in the wastewater stream. Therefore, this study was initially dedicated to the development of novel separation methods which would be suitable for the Total Whey Utilization process. The development of those techniques revealed some previously unknown feature of whey components. The mechanisms of the separation methods have been also investigated. Although crystallization is an efficient method for fractionation or purification, its disadvantage is that the mother liquor is a wastewater containing high salt and BOD (Biological Oxygen Demand). The chromatographic method has been investigated in this work to separate the mother liquor or permeate into lactose and mineral fractions such that a goal of this thesis, namely a 'clean' water stream after processing whey, can be finally achieved. These studies have focused on the effect of resin type, salt form of the resin and the operating conditions on the separation of the lactose and mineral fraction.Doctor of Philosophy (PhD)
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Xu, Yue. "Isolation and characterization of components from whey /." View thesis, 1996. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030808.133723/index.html.
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Southcott, Laura. "Components of premating reproductive isolation in threespine stickleback." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36522.
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Reproductive isolation, the reduction in gene flow between two species, is central to the study of speciation. Many so-called isolating barriers may be involved in preventing two species from successfully hybridizing, but the importance of each barrier and the presence of interactions between them have not often been measured. I investigated habitat and mating isolation in the recently diverged benthic-limnetic species pairs of threespine stickleback (Gasterosteus aculeatus species complex). In these species, the males of which build nests and guard territories during the breeding season, there is a strong pattern of male habitat choice, with limnetics nesting in open habitats and benthics nesting under vegetation. When males were given a choice of nesting habitats in enclosures in an artificial pond, they almost always chose according to this pattern. However, females displayed no difference in probability of spawning with conspecifics in different habitats in no-choice mating trials, making habitat isolation at best a weak barrier to hybridization in the absence of interactions with other isolating mechanisms. From an existing dataset of mate choice trials, I calculated the contributions of body size differences and male nuptial colour to mating isolation. Isolation due to body size differences was strong in both species, but stronger in benthics. Isolation due to colour preference was negligible in benthics and moderately strong in limnetics. Generalized linear models indicated that interactions with other, unspecified species-specific traits increases isolation due to body size and, in benthics, due to colour. Together, these traits provide strong but incomplete premating isolation, resulting in an expected hybridization rate higher than that observed in nature, and thus are not sufficient in themselves to maintain the species pairs.
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Dotimas, E. M. "Isolation, structure and action of bee venom components." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371865.
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Mizzi, Raphaël. "Mécanismes cognitifs et substrat neuronal de la hérarchisation de la saillance et de la progression de l'attention : approche psychophysique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE2122/document.
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Lorsque le système visuel est confronté à un nouvel environnement, un nombre trop important d’informations lui parvient en même temps. De façon précoce, avant tout mouvement oculaire, l’attention explore automatiquement la scène pour sélectionner les éléments d’intérêt. Des recherches récentes ont montré que cette exploration du champ visuel ne se faisait pas aléatoirement, mais se basait sur la saillance des éléments visuels. La saillance est une caractéristique qui émerge de la comparaison des éléments visuels entre eux, par exemple une fleur jaune dans un jardin de fleurs rouges va être considérée comme plus saillante que son voisinage. En permanence et de façon continue, une hiérarchie des éléments est établie à un niveau préattentif ; ils sont triés du plus au moins saillant, et l’attention se base sur cet organisation pour progresser dans le champ visuel. Les recherches présentées dans ce document avaient pour objectif d’investiguer les mécanismes de ce phénomène : quels sont les mécanismes cognitifs impliqués dans la progression de l’attention sur la base de la hiérarchie de la saillance ? Le présent document regroupe des articles qui cherchent à répondre à cette question grâce à des travaux en Psychologie expérimentale. Par ailleurs, de nombreux travaux de Psychologie, Neurophysiologie et Neuroimagerie se sont penchés sur le substrat neural de l’attention visuelle et ont révélé un ensemble de structures clés qui sous-tendraient les mécanismes responsables des fonctions attentionnelles. Cependant, vis-à-vis de la progression de l’attention sur la base de la saillance, seule une étude récente a pu apporter des indices quant au rôle de certaines voies visuelles. Les recherches présentées ici avaient donc également pour objectif de définir ces voies visuelles et les structures corticales et sous-corticales qui les composent, pour investiguer leurs rôles dans la hiérarchie de la saillance et la progression de l’attention. Le présent document regroupe des travaux qui ont exploré ces aspects par le biais de l’approche Psychophysique et ElectroencéphalographiqueWhen confronted to a new environment, the visual system faces too much information intake and cannot process it all at once. Before any eye movement, early automatic attention explores the visual scene in order to select relevant items.Recent research revealed that the exploration of the visual scene is not a random process, but is based on the respective saliency of the items in the field. Salience is not a characteristic of an item per se but is emerging as a result of the comparison between an item and its visual neighborhood. For instance, a yellow flower in a garden of red flowers will be considered as more salient than the others in its visual neighborhood. Thus, a hierarchical ordering of the items is continuously established in a preattentive stage, and consists in a sorting of every element from the most to the least salient. Attention, then, relies on this hierarchy to progress in the visual field. The present dissertation had for objective to investigate the cognitive mechanisms involved in this phenomenon: what mechanisms support the salience-based progression of visual attention? Several papers are reported here and explored this question with experimental Psychology.Moreover, numerous works in Psychology, Neurophysiology and Neuroimaging took interest in the neural substrate of visual attention and revealed several key-structures that would subtend the mechanisms involved in attentional functions. However, when it comes to the salience-based progression of attention, only one study could bring cues of the involvement of certain visual pathways in this phenomenon. Another objective of the present dissertation was to define the cortical and sub-cortical structures that constitute those pathways, in order to explore their roles in the salience-base progression of attention. Several papers in the present report are investigating this aspect through Psychophysics and Electroencephalography studies
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Christopherson, Indu P. Cheung H. Tak. "Isolation and characterization of extracellular matrix components from bovine bone marrow." Normal, Ill. Illinois State University, 1996. http://wwwlib.umi.com/cr/ilstu/fullcit?p9720805.
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Thesis (Ph. D.)--Illinois State University, 1996.Title from title page screen, viewed May 30, 2006. Dissertation Committee: H. Tak Cheung (chair), Herman E. Brockman, Alan J. Katz, Marjorie A. Jones, Brian J. Wilkinson. Includes bibliographical references (leaves 97-105) and abstract. Also available in print.
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Stone, Howard C. "Isolation and characterisation of cadmium binding components of the scallop, Pecten maximus." Thesis, University of Aberdeen, 1985. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU356206.
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1. The digestive gland of the scallop Pecten maximus naturally contains a very high concentration of cadmium (100 ppm wet weight), which does not show individual or seasonal variations. 2. About 60% of the tissue cadmium is soluble (i.e. is found in the supernatant when homogenate is centrifuged for 1 hour at 100,000g) and is bound to three main types of macromolecule. Most (about 60%) of this metal is associated with a component of molecular weight 55,000, the rest being bound to a low molecular weight species and, probably non-specifically, to components of very high molecular weight (greater than 100,000 molecular weight). The latter components were not further characterised. 3 The major binding component complexes the Cd2+ via sulphydryl groups, and so has a high cysteine content, but the binding is weaker than that of cadmium to metallothionein. The component has a high content of glutamate and aspartate (or their amides) and contains aromatic amino acids. It may also have a small carbohydrate content.4. The major cadmium binding component was susceptible to degradation by endogenous proteolytic enzymes. A major digestive enzyme was identified as a chymotrypsin which could be inactivated with phenylmethanesulphonylfluoride. Addition of PMSF to the homogenate reduced the total proteolytic activity of the digestive gland cytosol by up to 75%. Attempts to further inhibit, or remove, the remaining protease activity were largely unsuccessful. Probably as a result of the action of the proteolytic enzymes on the major cadmium component efforts to isolate the latter were characterised by irreproducibility, and satisfactory purification was not achieved. 5. The low molecular weight cadmium binding component binds 10-15% of the total soluble cadmium and exhibits many of the characteristics of a metallothionein. It has an apparent molecular weight of 10,000 on gel exclusion chromatography, high cadmium and cysteine contents and a high A250/A280 ratio. It is also heat stable and contains copper and zinc as well as cadmium. It can be detected by the metallothionein assay of Eaton & Toal (1982). 6. Preparations of both the major Cd binding component and metallo-thionein-like component contained relatively large amounts of carbohydrate, but the latter was probably not associated with these proteins. Its origin is unknown.
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Wilson, C. F. "Identification of membrane components associated with the expression of the Rhesus D antigen on human red cells." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355331.
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Forister, Matthew Lewis. "Components of reproductive isolation within the Mitoura (Lepidoptera: Lycaenidae) species complex of Northern California /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
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Deshpande, Bhavana. "Development of pancreatic islet isolation system peripheral components - analysis of process variables and outcomes." Cincinnati, Ohio : University of Cincinnati, 2008. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1204913111.
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Thesis (M.S.)--University of Cincinnati, 2008.Committee/Advisors: Arthur J. Helmicki (Committee Chair), Horacio H.L. Rilo (Committee Member), Ali A. Minai (Committee Member). Title from electronic thesis title page (viewed Apr.30, 2008). Includes abstract. Includes bibliographical references.
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Mutyala, Srikanth Babu. "Development of efficient pancreatic islet isolation system redesign of critical components and analysis of process variables /." Cincinnati, Ohio : University of Cincinnati, 2008. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1205155166.
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Thesis (M.S.)--University of Cincinnati, 2008.Committee/Advisors: Arthur J Helmicki PhD (Committee Chair), Horacio LR Rilo MD (Committee Member), Ali A Minai PhD (Committee Member). Title from electronic thesis title page (viewed Apr.30, 2008). Includes abstract. Includes bibliographical references.
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Avent, N. D. "Isolation and characterization of erythrocyte membrane components that express the rhesus and related blood group antigens." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233769.
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MUTYALA, SRIKANTH BABU. ""Development of Efficient Pancreatic Islet Isolation System: Redesign of Critical Components and Analysis of Process Variables"." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1205155166.
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Lindberg, Stina. "Evaluation of a genomic work flow for the detection of Bacillus subtilis in animal feed and food samples." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6345.
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Bacillus anthracis is one of the most feared agents of biological warfare and causes the
deadly disease called anthrax. SVA (statens veterinärmedicinska anstalt) is working on a
project together with SLV (statens livsmedelsverk) where the target is to find rapid and
effective detection methods for Bacillus anthracis in animal feed and food samples. Bacillus
subtilis, which is harmless, was used in this study as a model organism to Bacillus anthracis.
A known concentration of vegetative Bacillus subtilis was spiked in animal feed and food
samples. The genomic work flow was based on automated DNA isolation and real time PCR.
The aim of the study was to screen for inhibitory components in the animal feed and food
samples using two different DNA isolation robots; Magnatrix 8000 and Biorobot EZ1. The
results showed that DNA of high quality was extracted from the samples with both robots.
However, the CT-value generated by the real time PCR showed considerable variation
depending on the sample matrix. Some samples, for instance egg and liver, were problematic
and gave low concentrations and high CT-values probably due to inhibitory components in the
samples. Further studies will be needed to solve these problems and optimize the methods that
were used in this study.
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Roostaei, Davoud. "Isolation and characterisation of anti-diabetic pharmacological activities of phytoestrogens and components of Moringa peregrina (Forssk) Fiori." Thesis, London Metropolitan University, 2015. http://repository.londonmet.ac.uk/1141/.
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Diabetes is an endocrine disease characterised by a chronic increase in blood sugar levels caused by a deficiency of insulin production, which leads to type 1 diabetes, or by a loss of tissue response to insulin, which leads to type 2 diabetes. The disease leads to disruption of metabolism, vascular damage and damage to the nervous system, as well as damage to other organs and systems. Type 2 diabetes is becoming more common throughout the world, due to poor nutrition and lifestyle, and genetic background. Efforts have accordingly been increased towards developing and refining treatments as well as to addressing the underlying causes of the disease. Many parts of the world have a documented history of the use of plants to treat diabetes, and these can be an attractive, local, alternative to expensive pharmaceutical medicines. Accordingly there is an increasing interest in identifying new phytochemicals with proven pharmacological effects on diabetes. The tree Moringa peregrina is commonly found throughout the Middle East and the oil from its seeds has been used for thousands of years. Other members of the Moringa family have recorded anti-diabetic family and Moringa peregrina was chosen for investigation in this work with the aim of characterising anti-diabetic activity from its leaves. Six extracts were prepared using solvents water, methanol, butanol, ethyl acetate, chloroform and hexane, based on standard extraction techniques. The study was designed to assess the effect of these six extracts on the uptake of glucose in a human hepatoma cell line (HepG2) using a well-studied fluorescent derivative of glucose, 2-2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino glucose (2-NBDG). The cells can take up 2-NBDG instead of glucose via glucose transporters and its uptake is indicative of the capacity of cells to take up glucose, i.e. of the number of active glucose transporters on the cell surface. The results revealed that the extracts prepared with ethyl acetate and chloroform increased glucose uptake significantly more than the other extracts. Moreover the effects of the extracts were rapid, with a one hour treatment producing a similar stimulation to a 24 hour treatment. These data were confirmed in a second method of investigation of the hypoglycaemic effect of the extracts, by measuring consumption of glucose from cell culture medium. A preliminary assessment of the effect of active extracts on expression of the main glucose transporter of HepG2 cells, GLUT1, by western blotting indicated no large changes in expression. Dietary phytoestrogens have been shown to play a beneficial role in obesity and diabetes, so the second part of this study investigated the effect of phytoestrogens on glucose uptake. Three phytoestrogens (daidzein, formonontein and genestin, which are naturally occurring isoflavones) were chosen. HepG2 cells showed a significant increase in glucose uptake after treatment with phytoestrogens compared to the control. In an attempt to identify the active phytochemicals that could account for the observed effects, extensive purification and characterisation of components from the ethyl acetate fraction was undertaken. Seven components were identified: (1) OEthyl 4-[(α-L-rhamnosyloxy)benzyl] thiocarbamate (E), (2) O-Butyl 4-[(α-Lrhamnosyloxy)benzyl] thiocarbamate (E), (3) 4-(α-L-Rhamnosyloxy)benzyl isothiocyanate, (4) ȕ-Sitosterol, (5) Daucosterol, (6) γ’-methyl-quercetin-3-Orutinoside (also known as isorhamnetin-3-O-rutinoside), (7) Rutin. In a final analysis an attempt was made to assess the effect of a representative set of three out of the seven components on basic metabolic activity of HepG2 cells using a Seahorse XF-24 analyser. The three components chosen were O-ethyl 4-[(α-L-rhamnosyloxy) benzyl] thiocarbamate (E), ȕ-sitosterol from the phytosterols family and Rutin. Real-time monitoring of cell metabolism by a Seahorse XF-24 auto analyser after two hours incubation with the three chosen compounds revealed that maximal respiration, non-mitochondrial respiration and spare respiratory capacity have trended towards an increase with ȕ-sitosterol and3-O-ethyl 4-[(α-Lrhamnosyloxy) benzyl] thiocarbamate (E) treatments compared to control. As no similar trends were observed in ATP production, the increased maximal respiration could increase metabolic activity at higher concentrations of glucose and account, in part for the effects observed on glucose consumption.
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Schläppi, Anna-Katharina. "The paraflagellar rod of Trypanosoma brucei : isolation and characterization of the genes coding for the major components /." Bern, 1989. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Vasiljev, Andreja. "Isolation and characterisation of the intermembrane space components of the mitochondrial TIM22 protein import machinery of Neurospora crassa." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-28243.
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Pisani, Angela Paulina Grandeaux. "ESTUDO DE CORTINAS BLACK-OUT COMO COMPONENTES NO ISOLAMENTO SONORO DE FACHADAS." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/7708.
Full textAbstract:
Buildings which have high levels of sound pollution and facades that do not isolate
outside noise are often found in large cities. This situation affects people s sound comfort and
health. In connection with that, there is the high cost of materials which offer good sound
reduction indices. This way, it is necessary to investigate alternative materials at lower costs,
such as the blackout curtains. Taking these factors into consideration, the aim of this study is
to examine the increase of sound isolation index (Rw) in relation to outside noise, through the
use of vynil and polyester curtains in windows. The tests were carried out at the Acoustic
Laboratory of the Federal University of Santa Maria. The results of the tests have shown the
performance of various curtains arrangements, resulting in a 2 to 5 dB increase in the sound
isolation index. Duplicating curtains enabled an increase of about 1 dB in relation to simple
curtains. There was no increase in the sound isolation index when overlapping the curtains.
Putting up glass wool panels of different thickness has not influenced in the facade sound
isolation. With this study, it has been possible to quantify the improvement of facades sound
isolation by putting up blackout curtains currently in the market.Nas grandes cidades, encontram-se freqüentemente edifícios submetidos a elevados níveis de poluição sonora, cujas fachadas não isolam adequadamente o ruído externo, situação esta que traz conseqüências para o conforto sonoro e para a saúde dos indivíduos. Associado a isto, está o alto custo dos materiais que apresentam bons índices de redução sonora, havendo a necessidade de se estudarem materiais alternativos, com custos menos elevados, como é o caso das cortinas black-out. Levando-se em conta estes fatores, o objetivo deste trabalho é averiguar o acréscimo no índice de isolamento sonoro a ruídos externos, gerado pela colocação de cortinas de vinil e de poliéster, sobrepostas a um elemento de fachada. Os ensaios foram realizados no laboratório do Setor de Acústica da Universidade Federal de Santa Maria. A partir dos resultados dos ensaios verificou-se o desempenho de várias composições de cortinas, obtendo-se um aumento de 2 à 5 dB no índice de isolamento sonoro. A duplicação das cortinas possibilitou um aumento em torno de 1 dB, em relação às cortinas simples. Não houve alteração no índice de isolamento sonoro com o transpasse das cortinas. A colocação de painéis de lã de vidro de diferentes espessuras pouco influenciou no isolamento sonoro da fachada. A partir deste trabalho, pôde-se quantificar qual a melhoria no isolamento sonoro das fachadas propiciada pela colocação de cortinas black-out à disposição no mercado.
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Ha, Tracy. "The role of pathogen defense signaling components in ABA signal transduction and isolation of an ABA/C23 signaling mutant." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1469579.
Full textAbstract:
Thesis (M.S.)--University of California, San Diego, 2009.Title from first page of PDF file (viewed Oct. 15, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 67-76).
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Champ, Karen Irisa. "Isolation and characterization of components of low temperature-induced signal transduction pathways in Poncirus trifoliata (L.) Raf. and Citrus paradisi Macf." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004379.
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Flory, Mark Randall. "Isolation and characterization of calmodulin-binding centrosome components related to Saccharomyces cerevisiae Spc110p from the fission yeast Schizosaccharomyces pombe and humans /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5061.
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Oliveira, Miriam Ricciulli de. "Aplicação da análise termogravimétrica na avaliação da interação entre os componentes do bagaço e da palha de cana-de-açúcar /." Guaratinguetá, 2020. http://hdl.handle.net/11449/192260.
Full textAbstract:
Orientador: Ivonete ÁvilaResumo: A biomassa apresenta-se como uma promissora alternativa aos combustíveis fósseis por ser renovável, de baixo custo e amplamente disponível. Esta pode ser obtida a partir de resíduos agroindustriais mostrando-se como um importante modelo de energia sustentável. Os principais componentes da biomassa são hemicelulose, celulose e lignina e, por possuírem diferentes propriedades químicas, influenciam diretamente na eficiência de um processo de conversão termoquímica. Metodologias convencionais atualmente aceitas na determinação dos principais componentes da biomassa requerem maior tempo e possuem alto custo. A análise termogravimétrica (TG) é uma técnica rápida e de baixo custo, resultando em curvas TG/DTG que fornecem uma indicação do percentual de cada um dos componentes da biomassa. Entretanto, não há uma metodologia aceita no sentido de substituir o método convencional por via úmida na determinação dos constituintes de materiais lignocelulósicos. Portanto, o objetivo deste estudo é avaliar o efeito da interação entre os componentes do bagaço e da palha de cana-de-açúcar (hemicelulose, celulose e lignina), isolados por diferentes tratamentos químicos, por meio da análise de sinergismo em ensaios termogravimétricos. Este estudo contribuirá para a elaboração de uma metodologia para determinação dos teores desses componentes por meio da análise termogravimétrica, com precisão similar aos métodos convencionais. Os resultados da caracterização química e a caracterização físico-quími... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Biomass presents itself as a promising alternative energy source to replace or reduce the use of fossil fuels because it is renewable, low cost and widely available. This can be obtained from agro-industrial waste, showing itself as an important model of sustainable energy. The main components of biomass are hemicellulose, cellulose and lignin and, due to their different chemical properties, they directly influence the efficiency of a thermochemical conversion process. Currently, the accepted methodologies for determining the main components of biomass require time and are expensive. Thermogravimetric analysis (TGA) is a fast and low-cost technique, resulting in TGA/DTG curves that provide an indication of the percentage of each biomass components. However, there is no accepted methodology in the sense to replace the conventional wet method use to determining the lignocellulosic materials components. Therefore, the objective of this study is to evaluate the effect of the interaction between the components of sugarcane bagasse and straw (hemicellulose, cellulose and lignin), isolated by different chemical treatments, through the analysis of synergism in thermogravimetric tests. This study will contribute to the development of a methodology for determining the content of these components through thermogravimetric analysis, with precision similar to conventional methods. The results of chemical characterization and physico-chemical characterization by FTIR and DRX technique of t... (Complete abstract click electronic access below)
Mestre
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Perrin, Rémi. "Characterization and design of high-switching speed capability of GaN power devices in a 3-phase inverter." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEI001/document.
Full textAbstract:
Le projet industriel français MEGaN vise le développement de module de puissance à base de compostant HEMT en GaN. Une des application industrielle concerne l’aéronautique avec une forte contrainte en isolation galvanique (>100 kV/s) et en température ambiante (200°C). Le travail de thèse a été concentré sur une brique module de puissance (bras d’onduleur 650 V 30 A). L’objectif est d’atteindre un prototype de facteur de forme peu épais, 30 cm2 et embarquant l’ensemble des fonctions driver, alimentation de driver, la capacité de bus et capteur de courant phase. Cet objectif implique un fort rendement énergétique, et le respect de l’isolation galvanique alors que la contrainte en surface est forte. Le manuscrit, outre l’état de l’art relatif au module de puissance et notamment celui à base de transistor GaN HEMT, aborde une solution d’isolation de signaux de commande à base de micro-transformateur. Des prototypes de micro-transformateur ont été caractérisés et vieillis pendant 3000 H pour évaluer la robustesse de la solution. Les travaux ont contribué à la caractérisation de plusieurs composants GaN afin de mûrir des modèles pour la simulation circuit de topologie de convertisseur. Au sein du travail collaboratif MEGaN, notre contribution ne concernait pas la conception du circuit intégré (driver de grille), tout en ayant participé à la validation des spécifications, mais une stratégie d’alimentation du driver de grille. Une première proposition d’alimentation isolée pour le driver de grille a privilégié l’utilisation de composants GaN basse-tension. La topologie Flyback résonante avec clamp permet de tirer le meilleur parti de ces composants GaN mais pose la contrainte du transformateur de puissance. Plusieurs technologies pour la réalisation du transformateur ont été validées expérimentalement et notamment une proposition originale enfouissement du composant magnétique au sein d’un substrat polymère haute-température. En particulier, un procédé de fabrication peu onéreux permet d’obtenir un dispositif fiable (1000 H de cyclage entre - 55 ; + 200°C), avec un rendement intrinsèque de 88 % pour 2 W transférés. La capacité parasite d’isolation est réduite par rapport aux prototypes précédent. Deux prototypes d’alimentations à forte intégration utilisent soit les transistors GaN basse tension (2.4 MHz, 2 W, 74 %, 6 cm2), soit un circuit intégré dédié en technologie CMOS SOI, conçu pour l’application (1.2 MHz, 2 W, 77 %, 8.5 cm2). Le manuscrit propose par la suite une solution intégrable de mesure de courant de phase du bras de pont, basé sur une magnétorésistance. La comparaison expérimentale vis à vis d’une solution à résistance de shunt. Enfin, deux prototypes de convertisseur sont décrits, dont une a pu faire l’objet d’une validation expérimentale démontrant des pertes en commutation réduitesThe french industrial project MEGaN targets the development of power module based on GaN HEMT transistors. One of the industrial applications is the aeronautics field with a high-constraint on the galvanic isolation (>100 kV/s) and ambient temperature (200°C). The intent of this work is the power module block (3 phases inverter 650 V 30 A). The goal is to obtain a small footprint module, 30 cm2, with necessary functions such as gate driver, gate driver power supply, bulk capacitor and current phase sensor. This goal implies high efficiency as well as respect of the constraint of galvanic isolation with an optimized volume. This dissertation, besides the state of the art of power modules and especially the GaN HEMT ones, addressed a control signal isolation solution based on coreless transformers. Different prototypes based on coreless transformers were characterized and verified over 3000 hours in order to evaluate their robustness. The different studies realized the characterization of the different market available GaN HEMTs in order to mature a circuit simulation model for various converter topologies. In the collaborative work of the project, our contribution did not focus on the gate driver chip design even if experimental evaluation work was made, but a gate driver power supply strategy. The first gate driver isolated power supply design proposition focused on the low-voltage GaN HEMT conversion. The active-clamp Flyback topology allows to have the best trade-off between the GaN transistors and the isolation constraint of the transformer. Different transformer topolgies were experimentally performed and a novel PCB embedded transformer process was proposed with high-temperature capability. A lamination process was proposed for its cost-efficiency and for the reliability of the prototype (1000 H cycling test between - 55; + 200°C), with 88 % intrinsic efficiency. However, the transformer isolation capacitance was drastically reduced compared to the previous prototypes. 2 high-integrated gate driver power supply prototypes were designed with: GaN transistors (2.4 MHz, 2 W, 74 %, 6 cm2), and with a CMOS SOI dedicated chip (1.2 MHz, 2 W, 77 %, 8.5 cm2). In the last chapter, this dissertation presents an easily integrated solution for a phase current sensor based on the magnetoresistance component. The comparison between shunt resistor and magnetoresistance is experimentally performed. Finally, two inverter prototypes are presented, with one multi-level gate driver dedicated for GaN HEMT showing small switching loss performance
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Denison, T. J. "The management of technology transfer from research institutes to industry: isolating key components of process success and failure." Thesis, Cranfield University, 1999. http://dspace.lib.cranfield.ac.uk/handle/1826/10644.
Full textAbstract:
"Innovate or die" is a long-standing creed in industry. Collaboration between
companies is one route that businesses are pursuing with vigour, in an
effort to gain competitive advantage.
Few UK companies look to the dedicated research institutes (DRDCs) that
exist as a source of innovation and industrial collaboration. This is despite
the high regard bestowed on the creative abilities of the scientific teams at
these centres of excellence. The purpose of this study is not to answer why
this is so, but to help improve the chances of success when it occurs.
The study was born out of a Government-funded LINK project, which
evaluated the benefits, to project commercialisation, of conducting market
research in tandem with the technical stages of R&D at public research
institutes. Exposure to the professional cultures, work ethos and personal
attitudes of team-members at the DRDCs and their commercial partners
alerted the researcher to the challenges presented by technology transfer
between such organisations.
The literature is populated by studies that detail the stresses and strains of
technology transfer. However, little attention has been directed exclusively
at cases involving DRDCs. The primary aim of the study is to identify the
driving forces behind technology transfer success from DRDCs to industry.
It draws on the framework of the IMP Group to structure the context of
investigation. It uses the findings of past studies to structure the content of
investigation.
A qualitative approach involving 13 detailed case studies constitutes its
methodology. The cases cover both public and privately-funded DRDCs in
the UK and the Netherlands, including examples from agricultural
engineering, food sciences and biotechnology.
The results highlight seven key antecedents as areas at which good
management practice should be targeted. The study concludes by
addressing the underlying mechanisms behind transfer process success. It
finds that it is too simplistic to focus on any one of the three dimensions of
technology transfer (organisational, human and environmental) 'at the
exclusion of the others, as past studies have done. Successful transfer is
found to depend on three cross-dimensional underlying mechanisms:-
• checking the innovation is appropriate to the recipient
• establishing a suitable transfer process
• and providing an effective conduit for routing the knowledge
transfer.
34
Denison, Tim J. "The management of technology transfer from research institutes to industry : isolating key components of process success and failure." Thesis, Cranfield University, 1999. http://dspace.lib.cranfield.ac.uk/handle/1826/10644.
Full textAbstract:
"Innovate or die" is a long-standing creed in industry. Collaboration between companies is one route that businesses are pursuing with vigour, in an effort to gain competitive advantage. Few UK companies look to the dedicated research institutes (DRDCs) that exist as a source of innovation and industrial collaboration. This is despite the high regard bestowed on the creative abilities of the scientific teams at these centres of excellence. The purpose of this study is not to answer why this is so, but to help improve the chances of success when it occurs. The study was born out of a Government-funded LINK project, which evaluated the benefits, to project commercialisation, of conducting market research in tandem with the technical stages of R&D at public research institutes. Exposure to the professional cultures, work ethos and personal attitudes of team-members at the DRDCs and their commercial partners alerted the researcher to the challenges presented by technology transfer between such organisations. The literature is populated by studies that detail the stresses and strains of technology transfer. However, little attention has been directed exclusively at cases involving DRDCs. The primary aim of the study is to identify the driving forces behind technology transfer success from DRDCs to industry. It draws on the framework of the IMP Group to structure the context of investigation. It uses the findings of past studies to structure the content of investigation. A qualitative approach involving 13 detailed case studies constitutes its methodology. The cases cover both public and privately-funded DRDCs in the UK and the Netherlands, including examples from agricultural engineering, food sciences and biotechnology. The results highlight seven key antecedents as areas at which good management practice should be targeted. The study concludes by addressing the underlying mechanisms behind transfer process success. It finds that it is too simplistic to focus on any one of the three dimensions of technology transfer (organisational, human and environmental) 'at the exclusion of the others, as past studies have done. Successful transfer is found to depend on three cross-dimensional underlying mechanisms:- • checking the innovation is appropriate to the recipient • establishing a suitable transfer process • and providing an effective conduit for routing the knowledge transfer.
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Adib, Natanzi Heshmatollah. "Effect of bonding variation and component combination on dynamic characteristics of compound semi-bonded carbon fiber reinforced elastomeric isolator (CSB-CFREI)." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59129.
Full textAbstract:
Over the past thirty years, seismic isolation has been considered a viable earthquake damage mitigation technique and has been implemented to protect new and existing structures. However, due to the high production cost and implementation challenges of conventional seismic isolators, application of this protective technology has been limited to high value buildings with important and sensitive contents. To ensure widespread application of the base isolation systems for ordinary residential and commercial buildings, especially in developing countries, not only the production cost must be reduced, but the implementation efficiency must improve as well. With this intention in this study, a new cost effective Elevated Semi-Bonded Carbon Fiber-Reinforced Elastomeric Isolator (ESB-CFREI) with lower production cost and higher implementation efficiency is designed, manufactured, and tested. The innovative ESB-CFREI undergoes lateral cyclic excitations with a unique deformation mechanism that differs from that of conventional Steel Reinforced Elastomeric Isolators SREI and Bonded and Un-Bonded Carbon Fiber Reinforced Elastomeric Isolators. The ESB-CFREI can be used in isolation as an independent “Component Isolator” or combined with other component isolators to form a CESB-CFREI “Compound Isolator.” According to the experimental results, isolators with different bonding levels (BL) are characterized by different overall dynamic characteristics. Depending on component combination configurations, the compound isolators have different average bonding values that result in different damping, effective lateral shear, and axial compression stiffness. Results from experimental tests on different compound isolators demonstrated that change in combination configuration effectively influences the dynamic characteristics of the compound isolator. Dynamic characteristics of component (ESB-CFREI) and compound isolator (CESB-CFREI) as low-cost seismic isolators were investigated by conducting analytical and experimental studies. The isolator’s effective lateral shear and axial compression stiffness along with the isolation efficiency (IE) were defined. The experimental outcome demonstrated the effect of bonding variation on the dynamic characteristics, performance, and efficiency of the ESB-CFREI. The effects of component combination on the dynamic characteristics of the compound isolators were also investigated. Component material testing to investigate the hyper-elastic behaviour of the isolator’s rubber component and long duration excitation tests to study the isolator’s durability and performance were conducted as well.Applied Science, Faculty of
Engineering, School of (Okanagan)
Graduate
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Curtis, Megan E. "Due to a Bone Marrow Transplant, is Loneliness From Hospital Isolation a Predictor of Health Outcomes." UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/515.
Full textAbstract:
Previous research indicates loneliness affects physiological and quality of life outcomes in oncology populations. However, minimal research has been conducted specifically on bone and blood marrow transplant (BMT) patients (Knight et al., 2013). To further explore this issue, we conducted a preliminary study to examine the relationship of loneliness with quality of life, immunological functioning, and other health indicators at six months post-transplant in BMT patients. The Functional Assessment of Cancer Therapies–BMT (FACT-BMT) was used to measure QOL and the UCLA Loneliness Scale Version 3 was used to assess general loneliness and loneliness experienced during hospitalization. We found that experiencing loneliness during hospital stay and experiencing loneliness in general was negatively associated with overall quality of life six months after a BMT. Specially, hospital loneliness was associated with poorer social well-being and poorer functional well-being; and loneliness in general was associated with poorer social well-being. In addition, loneliness during hospitalization was related to difficulty managing disease symptoms six-months after a transplant. Hospital loneliness was associated with higher neutrophil counts to monocyte counts 30 days after BMT, which is an indicator of poorer overall survival rate. However, loneliness during hospital stay was not associated with neutrophil to lymphocyte ratio. These results indicate that there is a relation between loneliness experienced during hospitalization and immunological functioning which may adversely impact recovery from a bone marrow transplant.
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Dehghanpoor, Sichani Ahmad. "Soil-pile-superstructure systems under combined horizontal and vertical strong ground motions." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207885/1/Ahmad_Dehghanpoor%20Sichani_Thesis.pdf.
Full textAbstract:
Highway bridges considered as important but possibly vulnerable superstructures must be studied under natural hazards, such as earthquakes, tsunamis, hurricanes. This thesis was a novel investigation on reinforced concrete bridges under coupled horizontal and vertical ground motions. A variety of ground motions has been examined for different classification of bridges and novel conclusions have been presented in the probabilistic and deterministic frameworks.
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Mou, Chai-Hung, and 牟嘉鴻. "Development of Novel Microwave Branch-Line Coupler, Dual-Band Rat-Race Coupler and Wideband Passive Isolation Component." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38125601258159899186.
Full textAbstract:
碩士國立臺灣科技大學
電子工程系
100
The aim of this thesis is to develop microwave branch-line couplers, dual-band rat-race couplers, and the passive isolation component based on new circuits structures. For the branch-line coupler design, asymmetrical E-equivalent sections are used to design lumped-element branch-line couplers with the improvement of the return loss bandwidth. To reduce the number of lumped-elements, in this thesis, the asymmetrical E-equivalent section is further evolved into asymmetrical π- and T- equivalent structures for the branch-line coupler design. For the dual-band rat-race coupler design, L sections are exploited to design dual-band rat race couplers. The L section is composed of a transmission line and a series LC resonator to have the dual-band property. By using L sections, this thesis develops five types of dual-band rat-race couplers. The miniaturized dual-band coupler only occupies a 10 % circuit size of the conventional one at the center frequency of the 1st passband. For the passive isolation component design, three sets of diamond-shape slot-coupled microstrip lines are integrated into a passive isolation component. Since the slot-coupled microstrip can provide a wideband and accurate quadrature phase difference, the developed passive isolation component can effectively improve the isolation level and bandwidth between transmitting and receiving ports. The developed isolation component has a 30 dB isolation of 44.9 %.
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FAN, GUAI-HUA, and 范冠華. "Isolation and identification on the active component in piper betle infloresence extract against benzo(a)pyrene-induced mutagenicity." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/14184378647365445898.
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WU, LI-QIN, and 吳麗琴. "Isolation of the bioactive components from dendrobium nobile." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/59827843232995853919.
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Ting, Siew Chin, and 陳曉琴. "Isolation and Identification of Antiviral Components of Schizonepeta tenuifolia (STE)." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/3btcc8.
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Chen, Bo-Nan, and 陳柏男. "Isolation and characterization of the pigment components from Meiothermus taiwanensis." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/46106992281106663678.
Full textAbstract:
碩士淡江大學
化學學系
92
The optimum growth conditions for Meiothermus taiwanesis (NTU 30) and the heavy metal tolerance were determined in this study. The result shows that the bacteria still can grow in the presence of 4 mM managanese ion. Meanwhile, a 103.9 Kd protein was induced to express inside the cell. Its physiological role is still unknown. Meiothermus taiwanesis (NTU 30) can accumulate manganese inside the cell membrane and cytoplasm. The concentrations were 17.7 and 56.25 μM, respectively. A deep-orange pigment, meiothin, was isolated from the cell membrane of the bacteria. Its extinction coefficient is 742.87 cm-1M-1, and molecule weight is 1177.6 as determined by electrospray mass spectrum. The potential effect of meiothin was investigated in vitro. This compound shows DPPH-radical scavenging activity, reducing capacity, and superoxide anion scavenging activity.
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Lei, Bo. "Isolation of cadmium-binding components from proteins of flaxseed (Linum usitatissimum L.)." Thesis, 2006. http://hdl.handle.net/2429/18451.
Full textAbstract:
Flaxseed contains the toxic heavy metal cadmium (Cd) at concentrations often exceeding the recommended maximum dietary intake limit. The objectives of this study were to investigate the distribution of Cd-binding components in flaxseed, and to establish a protocol for separating Cd-binding components from storage proteins. The results indicated that over 80% of Cd in flaxseed (NorMan cultivar) was extracted with proteins into Tris buffer. Fractionation of protein extracts by ion exchange chromatography yielded a major Cd-binding fraction eluting at 0.1 M NaCl with over 50% of the eluted Cd and less than 8% of the eluted proteins, while the major storage proteins were eluted into the 0.25 M NaCl fraction containing over 60% of the eluted protein and less than 25% of the eluted Cd. The Cd level in flaxseed was strongly influenced by growing location. Similar trends in percent distribution of Cd and protein for 15 flaxseed samples (5 cultivars grown in 3 locations) suggest that this fractionation protocol could form the basis for developing an industrial process to produce flaxseed proteins with low Cd content for use as food ingredients. Further separation of the 0.1 M NaCl eluted major Cd-binding fraction by size exclusion chromatography resulted in three peaks. The major components in the first two peaks were a 19 kDa protein and a 14 kDa protein, while 0.6-0.9 kDa constituents in the third peak were comprised of unusual amino acids or organic acids and a 649.7 Da component tentatively identified as Cd-(γ-Glu-Cys)₂ Gly. The second and third peaks bound over 40% of the Cd contained in the flaxseeds. This study also demonstrated in vitro protective effects of flaxseed components against toxicity by Cd and H₂O₂. The protein extract and the major Cd-binding fraction at a concentration of 110 μg/mL reduced Cd (300 μM) toxicity in THP-1 cell culture by 14% and 44%, respectively, and reduced H₂O₂ (0.06%) toxicity by 48% and 89%, respectively. The protein extract was also found to promote THP-1 cell growth in a dose dependent manner. Further investigations should be conducted to explore the underlying mechanisms and potential applications of flaxseed constituents.Land and Food Systems, Faculty of
Graduate
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Chia-Jui, Tsai, and 蔡佳芮. "Isolation and Identification of Herbal Components as FXR and PPAR alpha Modulators." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/57846858063680285593.
Full textAbstract:
碩士高雄師範大學
化學系
97
Hyperlipidemia is the life-threaten disease with an elevation of lipids including cholesterol, cholesterol esters, phospholipids and triglycerides in the bloodstream. Apart from hyperlipidemia, cholesterol also plays an essential role in the regulation of the progression of numerous important diseases including Alzheimer disease so generation of suitable cholesterol-lowering reagents is urgent to achieve. Especially, the development of safe Chinese herbal cholesterol-lowering reagents can offer hyperlipidemia patients an alternative choice as the long-term supplements. PPAR α and FXR are two members of nuclear receptor superfamily. Due to highly involving in the regulation of lipid-metabolisms, they are essential target proteins to develop cholesterol-lowering reagents by novel pharmaceutical companies worldwide. Atractylodes ovata is widely used in herbal diets as a tonic agent in Taiwan and it has several health-promoting functions, including antidiarrheal action, a benefit to the stomach, the arrest of abnormal sweating, a diuretic action. Pharmacologically, Atractylodes ovata was confirmed to possess tocolysis, hypoglycemic, anti-tumor, anti-coagulant effects. However, until now, no report has been disclosed to mention that Atractylodes ovata contains PPAR α and FXR modulators. In this study, we utilized the flash chromatography to isolate and purify active components from Atractylodes ovata and investigated their bioactivity against PPAR α and FXR by transient transfection reporter assays. The active compounds were identified through spectroscopy like NMR, DEPT, HMQC, HMBC, and H-H COSY. Here we identified four sesquiterpenes that act as FXR antagonists as well as PPAR α agonists, and one of them could induce HepG2 and HSC apoptosis which might be resulted from its ability to antagonize Bcl-XL and lead to activate p53. All the evidences from this study strongly suggest these sesquiterpenes should be potential plant drugs as the treatments of hyperlipidemia.
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Ho, Meng-Chi, and 何孟琦. "Isolation and Quality Control of Bioactive Chemical Components from Formosan Acmella oleracea." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/78875929724118405785.
Full textAbstract:
碩士高雄醫學大學
天然藥物研究所
101
Acmella oleracea (AO) is an annual herb native to the tropical parts of Africa and South America with a yellow flower head, which is commonly used in traditional folk medicine to cure toothaches, throat complaints, and stomatitis. Alkylamides, one category of AO major active components, are regarded for their diuretic, antibacterial, and anti-inflammatory activities. Besides the medicinal use, alkylamides are well-known for their anti-wrinkle activity and used in different skin care products. Despite the extensive use in cosmetic industry, the production and marketing of AO and its alkylamides face a critical threat due to the lack of a reliable quality assessment method to evaluate concentration of alkylamides. In this investigation, we report a convenient method for concentrating the alkylamide-rich fraction (ARF), from the ethanolic extract of AO flowers (EEF-AO). Using bio-activity guided isolation technique, five alkylamides, including spilanthol (3), (2E,6Z,8E)-N-(2-methylbutyl)-2,6,8-decatrienamide (4), (2E,5Z)-N-isobutylundeca-2,5-diene-8,10-diynamide (5), (2E)-N-isobutyl-2-undecene-8,10-diynamide (6), (2E)-N-(2-methylbutyl)-2-undecene-8,10-diynamide (7), and a mixture of steroids 1-2, compound 5 is new. To detect the concentration of these markers in different plant parts, a rapid HPLC-PDA method for simultaneous detection of alkylamides from AO and A. ciliata (AC) was established. Two major alkylamides 3 - 4 were separated as the chemical markers of ARF. Using the developed HPLC-PDA protocol, the contents differences of major alkylamides in different part of AO and AC were achieved. Utilizing the efficient extraction, concentration and rapid analysis method not only provide necessary information about AO alkylamides concents in different plants parts but also provide a quality control assessment of AO alkylamides during different harvesting times.
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Lee, Ming-Yi, and 李明怡. "Isolation and identification of antitumor and anti-inflammatory active components from adlay bran." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/20905583499156011555.
Full textAbstract:
博士國立臺灣大學
食品科技研究所
96
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf ) is an one year grass crop that has long been used as a traditional Chinese medicine to treat tumor and inflammation. Recent studies have continuously demonstrated the physiological effects of adlay and reveal that duhulled adlay posseses a higher anti-tumor and anti-inflammation activity than polished adlay. In summation of references, the adlay seeds contain some anti-tumor or anti-inflammation active compounds especially in the adlay bran. However, the active constituents involved in anti-tumor or anti-inflammation activity are still unknown. Therefore, the aim of our study is based on to discuss function of anti-tumor and anti-inflammation in food, to separate and identify the physiological effective constituents contained in adlay bran via active fractions. The study results show that the ethyl acetate fraction from adlay bran methanolic extract (ABM-EtOAc) had the highest ability to reduce survival rate of lung and colorectal carcinoma cell. It is also found that inhibition of cell cycle phase change, and cell apoptosis. Concerning anti-inflammation research, ABM-EtOAc and ABM-BuOH subfractions all inhibit LPS-induced TNF-α and IL-1β which released from RAW 264.7. Furthermore, ABM-EtOAc and ABM-BuOH subfractions inhibit COX-2 expression of A549 and HT29 at 50 μg/ml concentration, while constitutive COX-1 expression is not affected. Moreover, the ABM-BuOH subfraction is the best. Thus, these results indicate that ABM-EtOAc and ABM-BuOH subfractions must have some anti-tumor or anti-inflammation active compounds. They inhibit cancer cell growth by promoting apoptosis of cancer cell. The chemical compound of plant has preventative effects on chronic inflammation-related cancer. Furthermore, 25 pure compounds are isolated and identified by inhibiting growth of lung cancer and colon cancer. The coixspirolactam A, coixspirolactam B, and coixspirolactam C are newly identified compounds. Caffeic acid, protocatechuic acid, chlorogenic acid, 3-O-coumaroyl-5β-sitostanol, 3-O-caffeoyl-5β-sitostanol, methyl dioxindole-3-acetate and 24,25-oxidocycloartanol are first isolated from adlay. From the anti-tumor activity test, it shows that there are only Caffeic acid, Protocatechuic acid, and Chlorogenic acid have anti-tumor activity in phenolic acid. From another hand, via anti-inflammation activity, the nine pure compounds, which are not found in ABM-EtOAc, are isolated from ABM-BuOH using many different kinds of isolation technology. Including one Apocarotene: Loliolide, one triterpinoid: 3β-Hydroxyolean-18-en-28-oic acid, one lignan: Pinoresinol, one phenolic ester: (E)-methyl 3,4-dihydroxycinnamate, one sugar-link sterol: β-Sitosteryl-3β-glucopyranoside, one isoflavone: Biochanin A, three flavonoid: 5, 7-Dimethoxy-4''-hydroxyflavan, 4'', 5, 7-Trihydroxyflavone (apigenin), Farrerol, all of the nine pure compounds are first isolated from adlay.
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Lorjarernchai, Waraporn, and 白茉莉. "Isolation and Analysis of Functional Components From Vegetable Enzymatic Hydrolysate of Soybean Okara." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/07284014285820002963.
Full textAbstract:
碩士中國文化大學
生物科技研究所
102
Soybean residue (okara) was found to have a function as angiotensin I-converting enzyme (ACE) inhibitor. In this study, the soybean residue was a kind of waste in soybean processing manufactory and was used to produce peptides by Papain-hydrolysis (from Papaya) or Bromelain-hydrolysis (from Pineapple). Bioactive peptides against ACE activity were focused and the potent bioactive peptides were separated by using molecular weight cut off and reverse-phase high-performance liquid chromatography (RP-HPLC) was used to assay the inhibitor activity of peptides. The function of peptide fractions was evaluated by the inhibitory activity against ACE. In this study, conditions for preparing small peptides from soybean by using vegetable enzyme hydrolysis were established. It showed that incubation of soybean residue with Papain at 70°C for 5 hours and Bromelain at 50°C for 5 hours could obtain hydrolysates with the smallest peptides and the highest amount of peptides. The fraction of peptides from soybean residues hydrolysate was separated according to different molecular weights by using ultrafiltration membrane cut-off ranging from 3,000 Da to 50,000 Da and each fraction used to evaluate inhibitory activity against ACE by RP-HPLC method. It was found that the peptide fractions from Bromelain hydrolysis showed a higher ACE inhibitory activity than that from Papain hydrolysis. In this case, the peptide fraction with high inhibitory activity against ACE was presented in crude hydrolysate, and with sequential decrease in inhibitory activity was in small peptide fraction 10-30 kDa, 3-10 kDa, and < 3 kDa, respectively. In conclusion, Bromelain is a good choice for producing peptides from soybean residues to have good inhibitory activity against ACE due to it could produce more peptides from soybean residues with very low concentration of proteolysis enzyme.
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Erstad, Kristin, Sylvi Høiland, Tanja Barth, and Per Fotland. "ISOLATION AND MOLECULAR IDENTIFICATION OF HYDRATE SURFACE ACTIVE COMPONENTS IN PETROLEUM ACID FRACTIONS." 2008. http://hdl.handle.net/2429/1404.
Full textAbstract:
The anti-agglomerating hydrate behavior observed for some crude oils has previously been
related to crude oil composition and to surface adsorption mechanisms. Petroleum acids derived
from some crude oils have been found able to convert systems with initially high risk of plugging
into easily flowable dispersions. In this work, acid fractions are isolated from three oils with low
tendency to form hydrate plugs and from two oils associated with high risk of hydrate plugging
by using an ion-exchange resin. The extracts are further separated into four sub-fractions by solid
phase extraction (SPE). The chemical composition of the fractions is studied by means of HPLC,
GPC, FTIR- and UV/VIS spectroscopy and elemental analysis. The distribution of chemical
compound classes in the fractions differs between the non-plugging and plugging oils, and the
differences are most distinctive in one of the sub-fractions. The results imply that acid sub-fractions
holding a significant proportion of more weakly polar compounds, like ester functionalities, are
important for how the hydrate surfaces and the oil phase interact.
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Hsu, Wenkuang, and 許文光. "Isolation, Purification, and Determination of Functional Components in Fermentation of Coriolus versicolor LH1." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/82985524581442424135.
Full textAbstract:
博士大葉大學
生物產業科技學系
101
Intracellular polysaccharides (iP) and extracellular polysaccharides (eP) were separated and purified from Coriolus versicolor LH1 mycelia and its culture mediem, respectively. iP and eP have been characterized for their α-glucosidase inhibitory, antioxidant properties, and chemical components. Two polysaccharides fractions (ePL-F6-2 and iPL-F5-5-1) were extracted, separated, and purified from LH1 mycelia and its culture medium by using microwave extraction technology, a DEAE-SepharoseTM CL-6B column, a Diaion® HP20 macroporous adsorption column, and a SephadexTM G-50 gel-permeation column. The principal constituents of ePL-F6-2 and iPL-F5-5-1 were polysaccharides-composites. The α-glucosidase inhibition activity, IC50 values, of these two fractions were 0.9 mg/mL and 0.8 mg/mL, respectively. The antioxidant activity, EC50 values, of the best activity fraction was ePL-F6-2 in 0.2 mg/mL. The type of α-glucosidase inhibition was competitive owing to the glycosidic bonds (α-1,4-glucosidic linkages) in the iPL-F5-5-1, and noncompetitive in ePL-F6-2. In our research, two-stage separation and purification strategy instead of the Sevag method to obtain purified polysaccharides from the iP and the eP of C. versicolor LH1 mycelia. Furthermore, the ePL-F6-2 and iPL5-5-1 fractions have potential to treat diabetes because of their α-glucosidase inhibitory activity.
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Chen, Hong-Jhang, and 陳宏彰. "Allergic Immune-regulatory Effects of Adlay Bran and Isolation and Identification of Bioactive Components." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/j3gu8m.
Full textAbstract:
博士國立臺灣大學
食品科技研究所
98
Allergy is an immune dysfunction, including atopic dermatitis, allergic rhinitis, asthma, etc. In Taiwan, the allergic disease is more and more prevalent. In addition to the usage of drugs to stop the allergic responses, taking advantage of dietary regimen is more important to regulate the immune system, to reduce the allergic symptom and avoid the waste of drugs. The inflammatory response is caused by allergic mediators such as histamine released and cytokine secretion by the mast cell, and the inflammatory response activated by macrophage. Therefore, we first investigated the anti-allergic and anti-inflammatory effects of ethanolic extracts of adlay on the RBL-2H3 cells and RAW 264.7 cells. Except the polished adlay, the ethanolic extracts from different parts of adlay can suppress the β-hexosaminodase released from RBL-2H3 cells stimulated with 1 μM A23187. The ethyl-acetate fraction from ethanolic extracts of adlay bran (ABE-EtOAc) presented more effective inhibition with an EC50 at 40.8 μg/mL. The 40~100% EtOAc/Hex sub-fractions of ABE-EtOAc can significantly inhibit the release of histamine with EC50 between 71~87 μg/mL Moreover, ABE-EtOAc suppressed IL-4, IL-6 and TNF-α secreted from RBL-2H3 cells indicated that the adlay bran can inhibit not only the cell degranulation but also the cytokine secretion. The alday contains anti-allergic compounds, such as palmitic acid, 4-hydroxybenzaldehyde, 6-methoxy-3H-benzoxazol, 4-hydroxyacetophenone, p-coumaric acid and quercetin, can reduce ROS production, inhibit the phosphorylation of Akt and ERK, and decrease the PKC protein expression. These combined effects influence the signaling transduction in RBL-2H3 cells, and showing the anti-allergic effect. The 40~100 % EtOAc/Hex sub-fractions of ABE-EtOAc at 50 μg/mL has no toxicity on the RAW 264.7 cells and inhibit the NO release. Furthermore, the result that ABE-EtOAc suppresses the IL-6 and TNF-α secretion in LPS (1 μg/mL)-stimulated RAW 264.7 cells in concentration dependent manner at 6~30 μg/mL. From above results demonstrates that the adlay bran has an anti-inflammatory effect. In the primary cells isolated from mice study, ABE-EtOAc suppressed the IL-6 and TNF-α secretion from peritoneal macrophages revealing the anti-inflammatory effects ex vivo. Furthermore, ABE-EtOAc can regulate the Th1/Th2 immune reaction via up-regulating IL-2 and down-regulating IL-4 and IL-5. Moreover, ABE-EtOAc reduced the anti-OVA IgE production, increased IFN-γ secretion and decreased IL-4 and IL-5 secretion in OVA immunized BALB/c mice. The ABE-EtOAc affects allergic reaction through balances of Th1/Th2 immune responses. To explore the anti-allergic components, the ABE-EtOAc-40~100% EtOAc/Hex fraction was isolated. There are 22 compounds were isolated from adlay bran. Among them, 15 compounds were first isolated from the adlay including 12 flavonoids, tangeretin (FL1), new flavonoids (FL2), formononetin (FL3), davidigenin (FL4), homoeriodictyol (FL5), 6'', 5, 7-trihydroxy-4''-methoxyflavonone (FL6), isoliquiritigenin (FL8), liquiritigenin (FL9), 3,5,6,7,8,3'',4''-heptamethoxyflavone (FL10), 5,7,4''-trihydroxy-3''-methoxyflavone (FL11), 3,5,7,3'',4''-pentamethoxyflavone (FL12)and 3,5,7,4''-tetramethoxyflavone (FL13), and two chromones, 5-hydroxy-7-methoxychromone (C1), 5,7-dihydroxychromone (C2) and a phenolic ester, ethyl ferulate (PE1). In conclusion, various flavonoids were found in the active fraction of adlay bran. They are suggested to correlate with the allergic response of mast cell in early phase and the inflammatory reaction of macrophage in late phase. Moreover, ABE-EtOAc can balance the Th1/Th2 immune responses. As a consequence the ethanolic extracts of adlay bran strengthen the modulation of immune system and alleviate allergic symptoms.