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Academic literature on the topic 'Complex herbal antioxidants'
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Journal articles on the topic "Complex herbal antioxidants"
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Angeli, Lucrezia, Sebastian Imperiale, Yubin Ding, Matteo Scampicchio, and Ksenia Morozova. "A Novel Stoichio-Kinetic Model for the DPPH• Assay: The Importance of the Side Reaction and Application to Complex Mixtures." Antioxidants 10, no. 7 (2021): 1019. http://dx.doi.org/10.3390/antiox10071019.
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The 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay is widely used to determine the antioxidant activity of food products and extracts. However, the common DPPH• protocol uses a two-point measurement and does not give information about the kinetics of the reaction. A novel stoichio-kinetic model applied in this study monitors the consumption of DPPH• by common antioxidants following the second order reaction. The fitting of such decay yields the rate constant k1, which describes the main reaction between antioxidants and DPPH•, and the rate constant k2, which is attributed to a slower side reaction considering the products generated between the transient radicals (AO•) and another molecule of DPPH•. The model was first applied to antioxidant standards. Sinapic acid, Trolox and ascorbic and chlorogenic acids did not show any side reaction. Instead gallic, ferulic and caffeic acids achieved the best fitting with k2. The products of the side reaction for these compounds were confirmed and identified with high-resolution mass spectrometry. Finally, the kinetic model was applied to evaluate the antioxidant activity of eight herbal extracts. This study suggests a new kinetic approach to standardize the common DPPH• assay for the determination of antioxidant activity.
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Karakas, Zeynep, Yasin Yilmaz, Dolay Damla Celik, Agageldi Annayev, Selcan Demirel, and Serap Erdem Kuruca. "Total Oxidant and Antioxidant Capacity in Patients with Transfusion Dependent and Nondependent Beta Thalassemia." Blood 126, no. 23 (2015): 4573. http://dx.doi.org/10.1182/blood.v126.23.4573.4573.
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Abstract Background: The patients with β-thalassemia are usually under oxidative stress due to iron overload as a result of ineffective erythropoiesis and repeated transfusions. The endogen (uric acid, indirect bilirubin) and exogenous (ascorbic acid and vitamin E) antioxidants protect the cells from oxidative damage. The evaluation of antioxidant defense system can be easily done by measuring serum total antioxidant capacity. The aim of this study is to investigate the total oxidant (TOC) and antioxidant capacity (TAC) of patients with transfusion dependent (TDT) and nondependent (NTDT) β -thalassemia. Methods: Fifty eight patients (age range 3-59; median age 24 years) with β-thalassemia (16 nontransfusion dependent, 42 transfusion dependent) who were followed-up by Istanbul Medical Faculty Thalassemia Center were enrolled in this study. The sex and age matched 25 healthy subjects were used as control group. The total oxidant and antioxidant capacity were measured by Rel Assay Diagnostics, Total Oxidant Status (TOS) kit and Total Antioxidant Status (TAS) kit. The statistics of results were done by SPSS version 21. Results: 58 patients were included consisting of β thalassemia intermedia (n=16) and β thalassemia major (n=42). The total oxidant capacity was found higher in patients than control group without significant differences. Beside this, the antioxidant capacity of patients was significantly increased (2.75 mmol/l vs 1.94 mmol/l; p=0.001). Within patients group, there was no significant differences in terms of TAC while the TOC level was high in NTDT (2.99 mmol/l vs 1.88 mmol/l; p=0.08). There was no significant relationship between TOC and sex, age (<18 vs >18 years), ferritin and splenectomy status, as the same for TAC. Conclusions: The oxidative damage in patients with β-thalassemia can trigger the morbidity. The measurement of TOC and TAC status stands a useful, rapid, and simple method to evaluate the complex oxidative mechanism of disease. There are still controversial results about antioxidant status in thalassemia patients. The irregular consume of supportive treatment such as zinc, vitamin C, vitamin E and herbal medicine may affect the TOC and TAC status. The results of this study can guide us to use the antioxidants to decrease the oxidative stress. Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.
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Horyn, O. I., та H. I. Falfushynska. "ЕКСТРАКТ МОМОРДІКИ ПРИГНІЧУЄ ОКИСНИЙ СТРЕС ТА ЗБІЛЬШУЄ ГЕМОЛІТИЧНУ СТІЙКІСТЬ ЕРИТРОЦИТІВ КОРОПА ЗА ВПЛИВУ ГЛЮКОЗИ". Scientific Issue Ternopil Volodymyr Hnatiuk National Pedagogical University. Series: Biology 75, № 1 (2019): 21–28. http://dx.doi.org/10.25128/2078-2357.19.1.3.
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Phytoextracts and natural antioxidants should provide promising results in therapeutic intervention for diabetes mellitus when they include into medical treatment scheme. The present study aimed to investigate the effect of Momordica charantia phytoextract alone and in complex-form with nano zinc oxide as well as zinc compounds on rate of hemolysis and oxidative stress parameters in Cyprinus carpio red blood cells (RBC) after their exposure to high glucose in vitro. The results have shown that the glucose treatment was capable to promote an increase in oxidative damage of lipids and proteins, the break of balance in antioxidant defence and enhance the rate of hemolysis and methylglyoxal concentration. When glucose-treated RBC were probed with M. charantia extract, nZnO- Momordica, nZnO and zinc picolinate specific response to different co-exposures was disclosed. Zinc picolinate in general had no significant effect on the studied parameters with few exceptions, then ZnO nanoparticles made glucose effects more profound. Momordica in herbal extract form and, particularly, in green synthetized ZnO nanoparticle have caused the decrease in lipid and protein peroxidation, glutathione trasferase activity, rate of hemolysis and methylglyoxal, and the increase in catalase and glutathione up to control baseline. These results have pointed to the necessity of further investigations of antihyperglycemic activity of Momordica and mechanistic explanation of its potentials.
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Capodice, Jillian L., Debra L. Bemis, Ralph Buttyan, Steven A. Kaplan, and Aaron E. Katz. "Complementary and Alternative Medicine for Chronic Prostatitis/Chronic Pelvic Pain Syndrome." Evidence-Based Complementary and Alternative Medicine 2, no. 4 (2005): 495–501. http://dx.doi.org/10.1093/ecam/neh128.
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To discuss challenges concerning treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and review complementary and alternative medical (CAM) therapies being evaluated for this condition, we performed a comprehensive search of articles published from 1990–2005 using the PubMed, Medline databases. Data from the articles were abstracted and pooled by subject. Keywords cross-searched with CP/CPPS included: complementary, alternative, integrative, therapies, interventions, nutrition, antioxidants, herbs, supplements, biofeedback and acupuncture. Listed articles with no abstracts were not included. Various CAM therapies for CP/CPPS exist including biofeedback, acupuncture, hyperthermia and electrostimulation. Additionally, a variety ofin vitroandin vivostudies testing herbal and nutritional supplements were found. Saw palmetto, cernilton and quercetin were the most frequently tested supplements for CP/CPP Although many CAM therapies demonstrate positive preliminary observations as prospective treatments for CP/CPPS, further exploratory studies including more randomized, controlled trials are necessary for significant validation as treatment options for this complex disorder.
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Faria, TC, C. C. H. C. Nascimento, S. D. D. De Vasconcelos, and P. R. S. Stephens. "Literature Review on the Biological Effects of Taraxacum Officinale Plant In Therapy." Asian Journal of Pharmaceutical Research and Development 7, no. 3 (2019): 94–99. http://dx.doi.org/10.22270/ajprd.v7i3.502.
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Since human beings have sought in nature, components that can obtain help in therapeutics or even in the cure of diseases. The progress made in the area of science promoted the development of recognized and effective herbal medicines, as well as the search for the population, for less aggressive treatments. The evaluation of the antioxidant activity of plants has been an important issue taking into account its importance on human health, since the natural antioxidants present a reduced health risk, when compared to the synthetic ones that present toxic effect. From the Asteraceae family, of which the plant species Taraxacum officinale, popularly known as dandelion, stands out among the 71 species on the list of the Ministry of Health (RENISUS), scientifically affirmed, to treat liver disorders, inflammations, potential in the anti-bacterial, cytotoxic, antiviral, antiparasitic, antifungal activity, besides studies to verify its anticancer action and of carcinogenic prevention. The acute toxicity of Taraxacum officinale appears to be low, with LD50 values estimated at 36.8g / kg and 28.8g / kg, for the whole plant. The adverse or complex toxic effects for T. officinale have not yet been reported. This review of the literature was elaborated through studies of articles contained in the Scielo, Google Scholar and Pub Med platforms. Through this review the importance of phytotherapy studies for pharmacological purposes was verified, aiming to improve the therapeutics.
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Chumburidze, Gocha. "The Effectiveness of Preservatives Used in Meat Production." Works of Georgian Technical University, no. 1(519) (March 29, 2021): 11–19. http://dx.doi.org/10.36073/1512-0996-2021-1-11-19.
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In order to store meat products for a long period of time, to maintain their quality and safety, meat producing companies use preservatives and antioxidants, which prove to be quite effective. However, they constitute some threat for the consumer. Various types of preservatives are used in meat processing companies in Georgia: “BOMBAL® ASC Super“, „BAKSOLAN-4”, “Standard Conservative”, “Standard Conservative Plus” and others. All of them represent a complex additive obtained through a chemical synthesis. For example, “BOMBAL ACS SUPER” is a mixture of three chemicalcompounds: Sodium Pyrosulphite (Е223), Sodium Acetate (Е262), and Sodium Citrate (Е331). There is a high probability of causing problems to digestive system, kidneys, and cardiovascular system, as well as allergic reactions when these conservatives get into a human organism. Consequently, it is essential to study the possibilities of much safer herbal conservatives usage. It is well known that many species of plants, such as ginger, rosemary, oregano (Origanum vulgare L), thyme (Thýmus), pennyroyal(Mentha pulegium), garlic and others possess antimicrobial and antioxidant qualities. These plants are wide-spread in a natural habitat in Georgia and are cultivated in the country as well. As it appears, the use of these herbs as conservatives in sausage making as well as other meat products will significantly reduce the risk of disease in customers. We find that a scientific research in this field has a lot of prospect.
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Prajakta N. Dongare, Tejashri B. Kadu, Ashish L. Pohane, Sachin J. Dighade, and Priyadarshani G. Patil. "Review on Pharmacognosy, phytochemistry and pharmacological activity of Taraxacum officinale (Dandelion plant)." World Journal of Advanced Research and Reviews 12, no. 2 (2021): 212–118. http://dx.doi.org/10.30574/wjarr.2021.12.2.0570.
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Taraxacum officinale (dandelion), a member of the Asteraceae family, commonly found in the temperate zone of the Northern hemisphere, is the perennial herb, forming a rosette leaf, golden yellow flowers that bloom year round. Dandelion leaves, roots and flowers is used in many traditional and modern herbal medicinal systems. On phytochemical investigation, Dandelion herb contains one or more vital phytochemical constituents. Similarly Among the most important compounds in dandelion Contains sesquiterpene lactones which is a bitter element, principally contains taraxacin and taraxacerin, which is principally important in mechanism of liver functions related with hepatoprotective action. Besides that result of the phytochemical investigation revealed the presence of sterols, phenolic acids, flavonoids, that have been shown to be associated with numerous pharmacological effects such as Antioxidants, anti immflammatory, antidiabetics, antitumor activity. Along with that the Dandelion leaves are a high efficient source of vitamins and minerals, including beta carotene, non-provitamin A carotenoids, xanthophylls, chlorophyll, vitamins C and D, many of the B-complex vitamins, choline, iron, silicon, magnesium, sodium, potassium, zinc, manganese, copper, and phosphorous which is also useful as a several nutritive action. This review will point out areas for future research of phytochemicals containing Taraxacum officinale where they shows more effective against various ailments and shows recent effective pharmacological activity
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Ray, Arunabha, Kavita Gulati, and Peter Henke. "Stress Gastric Ulcers and Cytoprotective Strategies: Perspectives and Trends." Current Pharmaceutical Design 26, no. 25 (2020): 2982–90. http://dx.doi.org/10.2174/1381612826666200521143203.
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Stress gastric ulceration is a clinical condition leading to morbidity/mortality and complex etiopathological factors are involved. Pharmacotherapy of such gastric mucosal lesions is not consistent and novel strategies are being explored. Targeting gastrointestinal factors have showed equivocal results and there is a possibility of involvement of extra-gastrointestinal factors. Stress is a highly interactive biological response in which the brain plays a key role. The involvement of brain substrates like the limbic system (amygdala, cortex, hippocampus) and behavioral traits has been investigated and research data has shown that the limbic brain-gut axis may be involved in the regulation of gastric mucosal integrity during stressful situations. The amygdaloid complex, its connections with other limbic structures and their neural networks act in tandem to contribute to both stress ulceration and gastroprotection. Complex neurotransmitter interactions in these areas involving biogenic amines and neuropeptides have been shown to modulate stress ulcerogenesis in experimental models. The immune system and brain-immune interactions also appear to play a decisive role in the genesis of such stress gastric lesions and the possibility of a brain-gut-immune axis has been proposed during stress gastric lesions. More recent studies have shown the involvement of oxidative stress and nitric oxide as well as their interactions during such stress gastric pathology, indicating the possible role of antioxidants and NO modulators as gastroprotective agents for stress ulceration. In view of the complex pathophysiology, multiple targets and lack of consistent therapeutic modalities, newer/alternative hypotheses are constantly emerging, which could be explored for effective treatment strategies aimed at gastric cytoprotection. Herbal agents with adaptogenic properties could be worth exploring in this regard as some of these phytopharmaceutical agents used in traditional medicine have been shown to exhibit gastric cytoprotection as part of their anti-stress profile. Further, their interactions with brain neurotransmitters and immune mechanisms and their relative safety could make them prospective leads for stress ulcer prophylaxis and treatment.
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Hamed, Eman M., Mohamed Hussein Meabed, Usama Farghaly Aly, and Raghda R. S. Hussein. "Recent Progress in Gene Therapy and Other Targeted Therapeutic Approaches for Beta Thalassemia." Current Drug Targets 20, no. 16 (2019): 1603–23. http://dx.doi.org/10.2174/1389450120666190726155733.
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Beta-thalassemia is a genetic disorder characterized by the impaired synthesis of the betaglobin chain of adult hemoglobin. The disorder has a complex pathophysiology that affects multiple organ systems. The main complications of beta thalassemia are ineffective erythropoiesis, chronic hemolytic anemia and hemosiderosis-induced organ dysfunction. Regular blood transfusions are the main therapy for beta thalassemia major; however, this treatment can cause cardiac and hepatic hemosiderosis – the most common cause of death in these patients. This review focuses on unique future therapeutic interventions for thalassemia that reverse splenomegaly, reduce transfusion frequency, decrease iron toxicity in organs, and correct chronic anemia. The targeted effective protocols include hemoglobin fetal inducers, ineffective erythropoiesis correctors, antioxidants, vitamins, and natural products. Resveratrol is a new herbal therapeutic approach which serves as fetal Hb inducer in beta thalassemia. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for beta thalassemia major and is preferred over iron chelation and blood transfusion for ensuring long life in these patients. Meanwhile, several molecular therapies, such as ActRIIB/IgG1 Fc recombinant protein, have emerged to address complications of beta thalassemia or the adverse effects of current drugs. Regarding gene correction strategies, a phase III trial called HGB-207 (Northstar-2; NCT02906202) is evaluating the efficacy and safety of autologous cell transplantation with LentiGlobin. Advanced gene-editing approaches aim to cut DNA at a targeted site and convert HbF to HbA during infancy, such as the suppression of BCL11A (B cell lymphoma 11A), HPFH (hereditary persistence of fetal hemoglobin) and zinc-finger nucleases. Gene therapy is progressing rapidly, with multiple clinical trials being conducted in many countries and the promise of commercial products to be available in the near future.
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Kulkarni, Nikhilesh, Jayshree Narwade, Rachana Pachori, and Prithviraj Sadar. "Microbial quality of herbal juices sold at sport complex in Washim." International Journal of Research in Medical Sciences 5, no. 11 (2017): 4946. http://dx.doi.org/10.18203/2320-6012.ijrms20174950.
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Background: Herbal juices are gaining global attention due to their medicinal properties, nutritive and antioxidant activity. They are frequently consumed by the people of all age groups in the form of health drinks. However, many outbreaks of human infections have been reported to be associated with the consumption of contaminated herbal juices. Hence, microbial quality assessment of herbal juices is utmost important.Methods: The present study was undertaken to detect the existence of enteric pathogens as well as coliforms in the herbal juices sold at sport complex in Washim city area. The antimicrobial susceptibility testing was also performed to evaluate the MDR status of the isolates.Results: The results showed that most of the herbal juices are contaminated with Salmonella, Shigella and Coliforms. The pathogens were found to be multiple drug resistant strains which pose an alarming threat for the consumers.Conclusions: Regular monitoring of the quality of herbal juices for human consumption is recommended to avoid disease outbreak.