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Journal articles on the topic 'Complex drives'

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Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

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1

Smith, Harvey W., Pierfrancesco Marra, and Christopher J. Marshall. "uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180." Journal of Cell Biology 182, no. 4 (August 25, 2008): 777–90. http://dx.doi.org/10.1083/jcb.200712050.

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The urokinase-type plasminogen activator receptor (uPAR) drives tumor cell membrane protrusion and motility through activation of Rac; however, the pathway leading from uPAR to Rac activation has not been described. In this study we identify DOCK180 as the guanine nucleotide exchange factor acting downstream of uPAR. We show that uPAR cooperates with integrin complexes containing β3 integrin to drive formation of the p130Cas–CrkII signaling complex and activation of Rac, resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion. Our findings identify a signaling pathway underlying the morphological changes and increased cell motility associated with uPAR expression.

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Singleton, A. B., and B. J. Traynor. "For complex disease genetics, collaboration drives progress." Science 347, no. 6229 (March 26, 2015): 1422–23. http://dx.doi.org/10.1126/science.aaa9838.

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3

Dey, Pranab Kumar. "Mine Winder Drives in Integrated Copper Complex." Journal of The Institution of Engineers (India): Series D 99, no. 1 (November 3, 2017): 147–55. http://dx.doi.org/10.1007/s40033-017-0150-3.

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4

McGraw, Marie C., and Elizabeth A. Barnes. "New Insights on Subseasonal Arctic–Midlatitude Causal Connections from a Regularized Regression Model." Journal of Climate 33, no. 1 (December 9, 2019): 213–28. http://dx.doi.org/10.1175/jcli-d-19-0142.1.

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ABSTRACT Arctic–midlatitude teleconnections are complex and multifaceted. By design, targeted modeling studies typically focus only on one direction of influence—usually, the midlatitude atmospheric response to a changing Arctic. The two-way, coupled feedbacks between the Arctic and the midlatitude circulation on submonthly time scales are explored using a regularized regression model formulated around Granger causality. The regularized regression model indicates that there are regions in which Arctic temperature drives a midlatitude circulation response, and regions in which the midlatitude circulation drives a response in the Arctic; however, these regions rarely overlap. In many regions, on submonthly time scales, the midlatitude circulation drives Arctic temperature variability, highlighting the important role the midlatitude circulation can play in impacting the Arctic. In particular, the regularized regression model results support recent work that indicates that the observed high pressure anomalies over Eurasia drive a significant response in the Arctic on submonthly time scales, rather than being driven by the Arctic.

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Suzdaltsev, V. E., and I. V. Fateev. "An Algorithm for Calculating of Complex Systems on the Bulk Hydraulic Transient Mode." Izvestiya MGTU MAMI 2, no. 1 (January 10, 2008): 106–14. http://dx.doi.org/10.17816/2074-0530-69611.

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The article is dedicated to the description of calculation algorithm for hydraulic drives of any configuration. The solution is received in the form of transient process of key parameters of drive: pressure, consumption, velocities, loads, etc. There are mentioned some differential equations for primary elements of hydrostatic drive system, the fundamentals for building of a computer program, which enable to modify it.

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Avlasko, P. V., and D. A. Antonenko. "Automated complex for research of electric drives control." Journal of Physics: Conference Series 1015 (May 2018): 032163. http://dx.doi.org/10.1088/1742-6596/1015/3/032163.

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Unverricht, James, Yusuke Yamani, and William J. Horrey. "Calibration in Older and Middle-aged Drivers: Relationship between Subjective and Objective Glance Performance at Complex Intersections." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 62, no. 1 (September 2018): 1913–17. http://dx.doi.org/10.1177/1541931218621434.

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Older drivers are an at-risk population for automobile crashes, especially at intersections. Intersection maneuvers demand a series of motor and visual responses executed at specific proximities and timings during a turn. Previous research indicates that older drivers are more likely than middle-aged drivers to neglect anticipatory glances to areas where latent hazards could materialize at intersections. Calibration, which reflects the degree of agreement (or discordance) between a driver’s self-perception of their driving ability and their actual ability, might be a factor that drives the age-related differences in visual scanning at intersections. This study examined relationships between eye movement patterns while driving through intersection scenarios in a medium-fidelity simulator and their subjective performance scores for middle-aged and older drivers. The data indicated no difference in calibration scores between older and middle-aged drivers. However, data showed that older drivers with higher subjective performance executed fewer secondary glances: this pattern was not present for middle aged drivers. Further research is necessary to identify psychological mechanisms involving driver calibration that control the age-related declines in anticipatory glance behavior at intersections.

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8

Brossard, Dominique, Pam Belluck, Fred Gould, and Christopher D. Wirz. "Promises and perils of gene drives: Navigating the communication of complex, post-normal science." Proceedings of the National Academy of Sciences 116, no. 16 (January 14, 2019): 7692–97. http://dx.doi.org/10.1073/pnas.1805874115.

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In November of 2017, an interdisciplinary panel discussed the complexities of gene drive applications as part of the third Sackler Colloquium on “The Science of Science Communication.” The panel brought together a social scientist, life scientist, and journalist to discuss the issue from each of their unique perspectives. This paper builds on the ideas and conversations from the session to provide a more nuanced discussion about the context surrounding responsible communication and decision-making for cases of post-normal science. Deciding to use gene drives to control and suppress pests will involve more than a technical assessment of the risks involved, and responsible decision-making regarding their use will require concerted efforts from multiple actors. We provide a review of gene drives and their potential applications, as well as the role of journalists in communicating the extent of uncertainties around specific projects. We also discuss the roles of public opinion and online environments in public engagement with scientific processes. We conclude with specific recommendations about how to address current challenges and foster more effective communication and decision-making for complex, post-normal issues, such as gene drives.

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9

Mikhov, Mikho, and Marin Zhilevski. "Study and Performance Improvement of the Drive Systems for a Class of Machine Tools." MATEC Web of Conferences 299 (2019): 05003. http://dx.doi.org/10.1051/matecconf/201929905003.

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This paper deals with some problems in the modernization of a type of machine tools with multi–coordinate drive systems. The basic requirements to the drives of each coordinate axis and the spindle are presented. Using the analysis carried out, a practical approach to appropriate selection of the respective drives is applied. The methodology offered is illustrated with some examples for choice of drives with direct current and alternating current motors. Some experimental research of cases with different feed and spindle drives are described and discussed. Better capabilities of the modernized machines for processing more complex workpieces are achieved, at a relatively low price. This research and the obtained results can be used in the design and tuning of electric drives for the considered type of machines with numerical program control.

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Pavlenko, A. V., V. P. Grinchenkov, A. A. Gummel, I. A. Pavlenko, and E. Kallenbakh. "Complex design of electromagnetic drives with prescribed dynamic performances." Russian Electrical Engineering 78, no. 4 (April 2007): 190–97. http://dx.doi.org/10.3103/s1068371207040050.

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11

Nikulin, Oleg, and Vitaliy Shabanov. "Electrotechnical complex of drill rig with adjustable electric drives." MATEC Web of Conferences 113 (2017): 01012. http://dx.doi.org/10.1051/matecconf/201711301012.

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12

Doigneaux, Cyrielle, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, and Ali Tavassoli. "Hypoxia drives the assembly of the multienzyme purinosome complex." Journal of Biological Chemistry 295, no. 28 (May 21, 2020): 9551–66. http://dx.doi.org/10.1074/jbc.ra119.012175.

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The purinosome is a dynamic metabolic complex composed of enzymes responsible for de novo purine biosynthesis, whose formation has been associated with elevated purine demand. However, the physiological conditions that govern purinosome formation in cells remain unknown. Here, we report that purinosome formation is up-regulated in cells in response to a low-oxygen microenvironment (hypoxia). We demonstrate that increased purinosome assembly in hypoxic human cells requires the activation of hypoxia inducible factor 1 (HIF-1) and not HIF-2. Hypoxia-driven purinosome assembly was inhibited in cells lacking 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a single enzyme in de novo purine biosynthesis, and in cells treated with a small molecule inhibitor of ATIC homodimerization. However, despite the increase in purinosome assembly in hypoxia, we observed no associated increase in de novo purine biosynthesis in cells. Our results indicate that this was likely due to a reduction in mitochondrial one-carbon metabolism, resulting in reduced mitochondrion-derived one-carbon units needed for de novo purine biosynthesis. The findings of our study further clarify and deepen our understanding of purinosome formation by revealing that this process does not solely depend on cellular purine demand.

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Morgado-Santos, Miguel, Henrique Miguel Pereira, Luís Vicente, and Maria João Collares-Pereira. "Mate Choice Drives Evolutionary Stability in a Hybrid Complex." PLOS ONE 10, no. 7 (July 16, 2015): e0132760. http://dx.doi.org/10.1371/journal.pone.0132760.

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14

Dorph, Annalie, Matthew Swan, Ellen Rochelmeyer, and Julian Di Stefano. "Complex habitat drives mammal communities in a flammable landscape." Forest Ecology and Management 462 (April 2020): 117979. http://dx.doi.org/10.1016/j.foreco.2020.117979.

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15

Karamguzhinova, A. E., V. N. Kuznetsova, V. V. Savinkin, and D. A. Koptyaev. "ELECTROHYDROCYLINDER OF INCREASED EFFICIENCY: PROSPECTS FOR THE DEVELOPMENT OF MECHATRONIC SYSTEMS." Russian Automobile and Highway Industry Journal 17, no. 1 (March 5, 2020): 22–31. http://dx.doi.org/10.26518/2071-7296-2020-17-1-22-31.

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Introduction. The problem of increasing the efficiency of power machines is important to develop a new design of the main elements or drive with the possibility of widespread use of hybrid drives. To preserve the power characteristics of the drive and its technical and operational indicators, the authors consider a hybrid with the available electric and hydraulic drive parts that form a complex synergistic mechanism as an alternative. The proposed combined tracking system with the specified parameters allows for the efficient operation of the drive of many machines.Materials and methods. The paper presented the results of an analytical study, the prospects for the development of mechatronic systems in engineering and technological complexes. The research also identified the industry area with a high development potential for mechatronic and hybrid drives. The authors formulated the problem of designing and developing hybrid drives due to the fact that there was no single method for substantiating the energy efficiency indicators of a power hybrid drive that ensured the interaction of two dissimilar systems (electric drive and hydraulic drive with fundamentally different parameters).Results. Therefore, the authors conducted the analysis of the structural, technological and operational parameters of the hybrid drive systems and proposed a combined servo drive system.Discussion and conclusions. The authors prove and justify the extensive possibilities of using hybrid drives as an alternative to pneumatic and hydraulic drives The results of the research allow specifying the directions and prospects of using hybrid synergetic drives and systems for the functioning of working equipment, machines and complexes.Financial transparency: the authors have no financial interest in the presented materials or methods. There is no conflict of interest.

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16

Su, Wen Yi, and Yu Ren Wu. "Design Optimization of a Rocker-Joint Silent Chain and Sprocket Drive Based on the Mesh Performance Indices." Applied Mechanics and Materials 197 (September 2012): 104–9. http://dx.doi.org/10.4028/www.scientific.net/amm.197.104.

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Improvement on noise, vibration and wear in silent chain drives is always an important research subject. However, design methods revealed in public are few because the silent chain shapes are variable and complex. A feasible design procedure is extremely required for improving transmission performance of chain drives. Therefore, a novel design optimization procedure for the rocker-joint silent (RJS) chain and sprocket drive is proposed in this paper. The mathematical models of geometry generation, tooth contact analysis and impact velocities at different mesh stages and chain raise amount in the RJS chain drive have been established. Besides, impact velocities and raise amount which may produce ill effects in the chine drive are incorporated as a multi-objective function to carry out the global minimization trying to find out the optimal design parameters for RJS chain drives. The single-objective optimization trends have also been verified with the previous references.

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17

Echarri, Asier. "A Multisensory Network Drives Nuclear Mechanoadaptation." Biomolecules 12, no. 3 (March 4, 2022): 404. http://dx.doi.org/10.3390/biom12030404.

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Cells have adapted to mechanical forces early in evolution and have developed multiple mechanisms ensuring sensing of, and adaptation to, the diversity of forces operating outside and within organisms. The nucleus must necessarily adapt to all types of mechanical signals, as its functions are essential for virtually all cell processes, many of which are tuned by mechanical cues. To sense forces, the nucleus is physically connected with the cytoskeleton, which senses and transmits forces generated outside and inside the cell. The nuclear LINC complex bridges the cytoskeleton and the nuclear lamina to transmit mechanical information up to the chromatin. This system creates a force-sensing macromolecular complex that, however, is not sufficient to regulate all nuclear mechanoadaptation processes. Within the nucleus, additional mechanosensitive structures, including the nuclear envelope and the nuclear pore complex, function to regulate nuclear mechanoadaptation. Similarly, extra nuclear mechanosensitive systems based on plasma membrane dynamics, mechanotransduce information to the nucleus. Thus, the nucleus has the intrinsic structural components needed to receive and interpret mechanical inputs, but also rely on extra nuclear mechano-sensors that activate nuclear regulators in response to force. Thus, a network of mechanosensitive cell structures ensures that the nucleus has a tunable response to mechanical cues.

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18

Mattingly, Brandon, Abinash Kar, Matthew Gorban, William Julius, Cooper K. Watson, MD Ali, Andrew Baas, et al. "Curvature Invariants for the Alcubierre and Natário Warp Drives." Universe 7, no. 2 (January 20, 2021): 21. http://dx.doi.org/10.3390/universe7020021.

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A process for using curvature invariants is applied to evaluate the metrics for the Alcubierre and the Natário warp drives at a constant velocity. Curvature invariants are independent of coordinate bases, so plotting these invariants will be free of coordinate mapping distortions. As a consequence, they provide a novel perspective into complex spacetimes, such as warp drives. Warp drives are the theoretical solutions to Einstein’s field equations that allow for the possibility for faster-than-light (FTL) travel. While their mathematics is well established, the visualisation of such spacetimes is unexplored. This paper uses the methods of computing and plotting the warp drive curvature invariants to reveal these spacetimes. The warp drive parameters of velocity, skin depth and radius are varied individually and then plotted to see each parameter’s unique effect on the surrounding curvature. For each warp drive, this research shows a safe harbor and how the shape function forms the warp bubble. The curvature plots for the constant velocity Natário warp drive do not contain a wake or a constant curvature, indicating that these are unique features of the accelerating Natário warp drive.

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Mitchell, Troy E. "MEF Innovation Team (MIT): Discovering and Solving the MEFs Complex Problems." Journal of Advanced Military Studies 11, no. 1 (June 16, 2020): 94–112. http://dx.doi.org/10.21140/mcuj.2020110104.

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Adversaries use cost-effective and timely technologies to counter expensive military acquisitions that undermine the United States’ military capabilities. With the private sector outpacing defense innovation, the speed of technology and business drives future warfare considerations. If technology corporations drive the speed of the future of warfare, then appreciating design thinking’s business model applicability to military strategy shapes how the Marine Corps responds to uncertain operating environments during the next several decades. This article incorporates aspects of design thinking for the Marine Corps to provide variables aiding in future warfare innovation to solve complex problems inherent to the future operating environment.

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20

Brodie, Jedediah F., and William D. Newmark. "Heterogeneous Matrix Habitat Drives Species Occurrences in Complex, Fragmented Landscapes." American Naturalist 193, no. 5 (May 2019): 748–54. http://dx.doi.org/10.1086/702589.

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21

Zaman, Luis, Justin R. Meyer, Suhas Devangam, David M. Bryson, Richard E. Lenski, and Charles Ofria. "Coevolution Drives the Emergence of Complex Traits and Promotes Evolvability." PLoS Biology 12, no. 12 (December 16, 2014): e1002023. http://dx.doi.org/10.1371/journal.pbio.1002023.

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22

Reddy, S. K., M. Rape, W. A. Margansky, and M. W. Kirschner. "Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation." Nature 446, no. 7138 (April 2007): 921–25. http://dx.doi.org/10.1038/nature05734.

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23

Liu, Kun, Dan Shen, Jingwen Shen, Shihong M. Gao, Bo Li, Chouin Wong, Weidong Feng, and Yan Song. "The Super Elongation Complex Drives Neural Stem Cell Fate Commitment." Developmental Cell 40, no. 6 (March 2017): 537–51. http://dx.doi.org/10.1016/j.devcel.2017.02.022.

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24

Gadeyne, Astrid, Clara Sánchez-Rodríguez, Steffen Vanneste, Simone Di Rubbo, Henrik Zauber, Kevin Vanneste, Jelle Van Leene, et al. "The TPLATE Adaptor Complex Drives Clathrin-Mediated Endocytosis in Plants." Cell 156, no. 4 (February 2014): 691–704. http://dx.doi.org/10.1016/j.cell.2014.01.039.

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25

Aron, Ravi, and Praveen Pathak. "Disaggregating the Differential Impact of Healthcare IT in Complex Care Delivery: Insights from Field Research in Chronic Care." Journal of the Association for Information Systems 22, no. 3 (2021): 618–48. http://dx.doi.org/10.17705/1jais.00675.

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This study focuses on the impact of digitizing medical information on the efficiency and perceived quality of chronic care delivery at the individual physician level. This study extends the theory of task technology fit to activity systems consisting of highly interdependent tasks. We find that the outcomes of efficiency and quality gains are driven by the structure of interdependencies between tasks that physicians perform. While structured information plays a key role in enabling both decision-making and task execution, we find that physician-created semistructured information is also an important predictor of both efficiency and quality gains. We show that the structure of activity systems (task interdependencies) has a strong moderating influence on the factors that drive efficiency and quality gains. We find that digitization enables physicians to preprocess patients’ records prior to their visit which in turn drives gains in both the efficiency and the perceived quality of care delivered.

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Zavialov, Anton V., Vladimir M. Tischenko, Laura J. Fooks, Bjørn O. Brandsdal, Johan Åqvist, Vladimir P. Zav'yalov, Sheila Macintyre, and Stefan D. Knight. "Resolving the energy paradox of chaperone/usher-mediated fibre assembly." Biochemical Journal 389, no. 3 (July 26, 2005): 685–94. http://dx.doi.org/10.1042/bj20050426.

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Periplasmic chaperone/usher machineries are used for assembly of filamentous adhesion organelles of Gram-negative pathogens in a process that has been suggested to be driven by folding energy. Structures of mutant chaperone–subunit complexes revealed a final folding transition (condensation of the subunit hydrophobic core) on the release of organelle subunit from the chaperone–subunit pre-assembly complex and incorporation into the final fibre structure. However, in view of the large interface between chaperone and subunit in the pre-assembly complex and the reported stability of this complex, it is difficult to understand how final folding could release sufficient energy to drive assembly. In the present paper, we show the X-ray structure for a native chaperone–fibre complex that, together with thermodynamic data, shows that the final folding step is indeed an essential component of the assembly process. We show that completion of the hydrophobic core and incorporation into the fibre results in an exceptionally stable module, whereas the chaperone–subunit pre-assembly complex is greatly destabilized by the high-energy conformation of the bound subunit. This difference in stabilities creates a free energy potential that drives fibre formation.

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27

Cohen, Sidney R., and Estelle Kalfon-Cohen. "Dynamic nanoindentation by instrumented nanoindentation and force microscopy: a comparative review." Beilstein Journal of Nanotechnology 4 (November 29, 2013): 815–33. http://dx.doi.org/10.3762/bjnano.4.93.

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Viscoelasticity is a complex yet important phenomenon that drives material response at different scales of time and space. Burgeoning interest in nanoscale dynamic material mechanics has driven, and been driven by two key techniques: instrumented nanoindentation and atomic force microscopy. This review provides an overview of fundamental principles in nanoindentation, and compares and contrasts these two techniques as they are used for characterization of viscoelastic processes at the nanoscale.

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Dhole, Sumit, Alun L. Lloyd, and Fred Gould. "Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex." Annual Review of Ecology, Evolution, and Systematics 51, no. 1 (November 2, 2020): 505–31. http://dx.doi.org/10.1146/annurev-ecolsys-031120-101013.

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The spread of synthetic gene drives is often discussed in the context of panmictic populations connected by gene flow and described with simple deterministic models. Under such assumptions, an entire species could be altered by releasing a single individual carrying an invasive gene drive, such as a standard homing drive. While this remains a theoretical possibility, gene drive spread in natural populations is more complex and merits a more realistic assessment. The fate of any gene drive released in a population would be inextricably linked to the population's ecology. Given the uncertainty often involved in ecological assessment of natural populations, understanding the sensitivity of gene drive spread to important ecological factors is critical. Here we review how different forms of density dependence, spatial heterogeneity, and mating behaviors can impact the spread of self-sustaining gene drives. We highlight specific aspects of gene drive dynamics and the target populations that need further research.

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29

Khmelnitskiy, I. K., V. V. Luchinin, A. N. Gorlyak, V. M. Aivazyan, N. I. Alekseyev, A. P. Broyko, Yu D. Orekhov, and A. M. Karelin. "Complex of Miniature Bionic Robotic Systems." Nano- i Mikrosistemnaya Tehnika 24, no. 1 (February 22, 2022): 13–18. http://dx.doi.org/10.17587/nmst.24.13-18.

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The developed and implemented complex of miniature bionic robotic systems is presented, including swimming and walking miniature biosimilar robots with low-voltage energy-efficient motion drives based on ionic polymer-metal composites; miniature autonomous robotized probes with a vibration propulsor for moving through small-diameter pipes and transmitting a video signal over a two-frequency radio channel; an ultralight zoomorphic flying platform with a movable wing — a robot ornithopter "Hummingbird".

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Domek, Grzegorz, Michał Wilczyński, and Tadeusz Woźniak. "Application of flat belts in advanced machine constructions." Mechanik 90, no. 11 (November 13, 2017): 1048–50. http://dx.doi.org/10.17814/mechanik.2017.11.177.

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The paper presents some issues of flat belts use in advanced machine designs. These belts allow realizing for the most complex drive and conveyor solutions as well as complex functions. They work in the drives at the highest speed, carry the highest torque, work with wheels arranged in various planes. With the use of modern material for belts, it is possible to obtain gearboxes with a wide range of applications, which should make them the most popular in machine construction.

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DANILUSHKIN, Alexander I., and Ivan A. DANILUSHKIN. "OPTIMIZATION OF ELECTROTECHNICAL POWER CONSUMPTION OF GAS COOLING SYSTEM COMPLEX." Urban construction and architecture 8, no. 1 (March 15, 2018): 124–29. http://dx.doi.org/10.17673/vestnik.2018.01.21.

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The problem of the optimal load distribution between electric drives of fans in a multi-section gas cooling unit is considered based on the minimum energy expenditure for cooling. The optimization problem is solved on the basis of the obtained analytical model for the gas temperature at the outlet of the cooling unit. The model takes into account the mutual infl uence of the operating modes of all fans of the installation. A technique for solving the problem of optimal load sharing between electric drives of fans for a linearized process model is developed using the procedure of integer programming. The optimization technique takes into account the individual characteristics of the devices.

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32

Hetmańczyk, Mariusz Piotr. "The Reliability Model of AC-Asynchronous Drive Based on the Multilevel Prognosis System Supported by Matrices and Digraphs Methods." Solid State Phenomena 199 (March 2013): 85–90. http://dx.doi.org/10.4028/www.scientific.net/ssp.199.85.

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Author of this article presents an authorship reliability model of a AC-asynchronous drive written in accordance with assumptions of the multilevel prognosis system based on matrices and digraphs methods. Described model take advantage of knowledge gathered from specialists on the basis of their experience. It is worth to stress that parameters of the reliability model of the AC-drive meet the requirements of units utilized in case of distributed drives. Each change of its application range requires a modification of internal parameters, but the functional structure remains without any variations, because presented reliability model has been based on the functional structure. An intention of the author is focused on an elaboration of a collection of reliability models [ of distributed drives components, prepared in accordance with the multilevel system of prognosis based on matrices and digraphs methods. The model has been specified to the level of the independent subsystem. This approach allows the use of this model in the analysis of complex systems, consisting of separated drive subsystems, which meet the requirements of the method. Using multilevel prediction models should be possible in all applications of electric drives, regardless of purpose functions.

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Findlay, Izac J., Geoffry N. De Iuliis, Ryan J. Duchatel, Evangeline R. Jackson, Nicholas A. Vitanza, Jason E. Cain, Sebastian M. Waszak, and Matthew D. Dun. "Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies." Oncogene 41, no. 4 (November 10, 2021): 461–75. http://dx.doi.org/10.1038/s41388-021-02102-y.

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AbstractDiffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall survival (OS) of just 9–11-months, DMG is characterized by global hypomethylation of histone H3 at lysine 27 (H3K27me3), driven by recurring somatic mutations in H3 genes including, HIST1H3B/C (H3.1K27M) or H3F3A (H3.3K27M), or through overexpression of EZHIP in patients harboring wildtype H3. The recent World Health Organization’s 5th Classification of CNS Tumors now designates DMG as, ‘H3 K27-altered’, suggesting that global H3K27me3 hypomethylation is a ubiquitous feature of DMG and drives devastating transcriptional programs for which there are no treatments. H3-alterations co-segregate with various other somatic driver mutations, highlighting the high-level of intertumoral heterogeneity of DMG. Furthermore, DMG is also characterized by very high-level intratumoral diversity with tumors harboring multiple subclones within each primary tumor. Each subclone contains their own combinations of driver and passenger lesions that continually evolve, making precision-based medicine challenging to successful execute. Whilst the intertumoral heterogeneity of DMG has been extensively investigated, this is yet to translate to an increase in patient survival. Conversely, our understanding of the non-genomic factors that drive the rapid growth and fatal nature of DMG, including endogenous and exogenous microenvironmental influences, neurological cues, and the posttranscriptional and posttranslational architecture of DMG remains enigmatic or at best, immature. However, these factors are likely to play a significant role in the complex biological sequelae that drives the disease. Here we summarize the heterogeneity of DMG and emphasize how analysis of the posttranslational architecture may improve treatment paradigms. We describe factors that contribute to treatment response and disease progression, as well as highlight the potential for pharmaco-proteogenomics (i.e., the integration of genomics, proteomics and pharmacology) in the management of this uniformly fatal cancer.

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Zyuzev, A. M., K. E. Nesterov, and M. V. Mudrov. "A hardware-software complex for real-time modeling of electric drives." Russian Electrical Engineering 85, no. 9 (September 2014): 591–96. http://dx.doi.org/10.3103/s1068371214090119.

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35

Mendoza, Michelle C., E. Emrah Er, Wenjuan Zhang, Bryan A. Ballif, Hunter L. Elliott, Gaudenz Danuser, and John Blenis. "ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex." Molecular Cell 41, no. 6 (March 2011): 661–71. http://dx.doi.org/10.1016/j.molcel.2011.02.031.

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36

Savenko, A. Е., and P. S. Savenko. "Research into powerful electric drives in the autonomous electrical power complex." Vestnik IGEU, no. 4 (2017): 44–49. http://dx.doi.org/10.17588/2072-2672.2017.4.044-049.

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37

Alsahafi, Zaki, Clayton T. Dickson, and Silvia Pagliardini. "Optogenetic excitation of preBötzinger complex neurons potently drives inspiratory activityin vivo." Journal of Physiology 593, no. 16 (July 14, 2015): 3673–92. http://dx.doi.org/10.1113/jp270471.

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38

Terada, T. P., M. Sasai, and T. Yomo. "Conformational change of the actomyosin complex drives the multiple stepping movement." Proceedings of the National Academy of Sciences 99, no. 14 (June 24, 2002): 9202–6. http://dx.doi.org/10.1073/pnas.132711799.

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39

Higginson, D. M., K. B. Miller, K. A. Segraves, and S. Pitnick. "Female reproductive tract form drives the evolution of complex sperm morphology." Proceedings of the National Academy of Sciences 109, no. 12 (February 7, 2012): 4538–43. http://dx.doi.org/10.1073/pnas.1111474109.

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40

Soetedjo, R., and A. Fuchs. "Activation of a cerebellar complex spike pathway drives saccade motor learning." Journal of Vision 9, no. 14 (December 1, 2009): 12. http://dx.doi.org/10.1167/9.14.12.

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41

Lyon, Andrew S., Geneviève Morin, Michelle Moritz, King Clyde B. Yabut, Tamira Vojnar, Alex Zelter, Eric Muller, Trisha N. Davis, and David A. Agard. "Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly." Molecular Biology of the Cell 27, no. 14 (July 15, 2016): 2245–58. http://dx.doi.org/10.1091/mbc.e16-02-0072.

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The microtubule (MT) cytoskeleton plays important roles in many cellular processes. In vivo, MT nucleation is controlled by the γ-tubulin ring complex (γTuRC), a 2.1-MDa complex composed of γ-tubulin small complex (γTuSC) subunits. The mechanisms underlying the assembly of γTuRC are largely unknown. In yeast, the conserved protein Spc110p both stimulates the assembly of the γTuRC and anchors the γTuRC to the spindle pole body. Using a quantitative in vitro FRET assay, we show that γTuRC assembly is critically dependent on the oligomerization state of Spc110p, with higher-order oligomers dramatically enhancing the stability of assembled γTuRCs. Our in vitro findings were confirmed with a novel in vivo γTuSC recruitment assay. We conclude that precise spatial control over MT nucleation is achieved by coupling localization and higher-order oligomerization of the receptor for γTuRC.

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Arif, A., P. Chatterjee, R. A. Moodt, and P. L. Fox. "Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages." Molecular and Cellular Biology 32, no. 24 (October 15, 2012): 5046–55. http://dx.doi.org/10.1128/mcb.01168-12.

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43

Sun, Huaiyu, Par Towb, Daniel N. Chiem, Byron A. Foster, and Steven A. Wasserman. "Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning." EMBO Journal 23, no. 1 (December 18, 2003): 100–110. http://dx.doi.org/10.1038/sj.emboj.7600033.

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Bressan, Michael, Trevor Henley, Jonathan D. Louie, Gary Liu, Danos Christodoulou, Xue Bai, Joan Taylor, Christine E. Seidman, J. G. Seidman, and Takashi Mikawa. "Dynamic Cellular Integration Drives Functional Assembly of the Heart’s Pacemaker Complex." Cell Reports 23, no. 8 (May 2018): 2283–91. http://dx.doi.org/10.1016/j.celrep.2018.04.075.

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Mock, Thomas. "Silicon drives the evolution of complex crystal morphology in calcifying algae." New Phytologist 231, no. 5 (June 24, 2021): 1663–66. http://dx.doi.org/10.1111/nph.17507.

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Wang, Xueqiang, Weiqiang Lv, Jie Xu, Adi Zheng, Mengqi Zeng, Ke Cao, Xun Wang, et al. "Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits." Advanced Science 9, no. 9 (January 17, 2022): 2105587. http://dx.doi.org/10.1002/advs.202105587.

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47

Goodman, C. J., and J. A. Taufiq. "Supply-Side Harmonics in d.c. Supplied Drives: An Approach to Their Specification and Control." Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit 203, no. 1 (January 1989): 45–49. http://dx.doi.org/10.1243/pime_proc_1989_203_207_02.

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The use of power electronic switching controllers for all types of traction drives can lead to harmonic currents on the supply side. These currents, by conductive or mutual coupling, can cause interference in signalling and telecommunications circuits. After reviewing these basic considerations, this paper outlines the harmonic spectra of d.c.-supplied chopper and inverter drives. In the case of chopper controllers, choosing a frequency unrelated to any signalling frequency combined with the attenuation provided by the input filter is usually sufficient to avoid dangerous interference. For inverter drives, the situation is more complex due to the intrinsic sweep frequency nature of the drive. However, special modulation strategies can be used for the inverter which eliminates, or at least reduces to a safe level, any particular frequency which may interfere with signalling equipment. A method for generating these optimized pulse-width modulation schemes using fast on-board microprocessors is briefly described.

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Barrero, Federico, Mario Bermudez, Mario J. Duran, Pedro Salas, and Ignacio Gonzalez-Prieto. "Assessment of a Universal Reconfiguration-less Control Approach in Open-Phase Fault Operation for Multiphase Drives." Energies 12, no. 24 (December 10, 2019): 4698. http://dx.doi.org/10.3390/en12244698.

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Multiphase drives have been important in particular industry applications where reliability is a desired goal. The main reason for this is their inherent fault tolerance. Different nonlinear controllers that do not include modulation stages, like direct torque control (DTC) or model-based predictive control (MPC), have been used in recent times to govern these complex systems, including mandatory control reconfiguration to guarantee the fault tolerance characteristic. A new reconfiguration-less approach based on virtual voltage vectors (VVs) was recently proposed for MPC, providing a natural healthy and faulty closed-loop regulation of a particular asymmetrical six-phase drive. This work validates the interest in the reconfiguration-less approach for direct controllers and multiphase drives.

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Pereira, Candida, Jorge Ambrósio, and Amilcar Ramalho. "Application of a Tensioner on a Chain Drives Multibody Model." Applied Mechanics and Materials 394 (September 2013): 140–43. http://dx.doi.org/10.4028/www.scientific.net/amm.394.140.

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The dynamics of chain drives is a complex issue due to the polygonal effect and the multiple successive impacts that take place. The combined effect of these phenomena leads to discontinuities in the systems velocities giving rise to transversal and longitudinal vibrations on the chain spans. To investigate the pretension effect on the drive dynamics, a tensioner is applied to a generalized chain drives multibody model developed and implemented in a computational code by the authors. In this model, the clearance revolute joints formulation is used to handle the dry contact between all drive components. The pretension changes the characteristics of the contact pairs by enforcing a continuous contact with only a small number of contact losses. When no pretension is used, the contact is characterized by a sequence of short duration contacts. The strands of the pretensioned chain vibrate with higher frequency but smaller amplitude in comparison to the non-pretensioned system.

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Brylystyi, Viktor, Olena S. Nazarova, and Volodymyr Osadchyy. "Torque measurement for researching the energy characteristics of electric vehicle drives." Electrical Engineering and Power Engineering, no. 4 (April 20, 2022): 36–44. http://dx.doi.org/10.15588/1607-6761-2021-4-4.

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Purpose. Development of a torque measuring unit as part of a laboratory complex for studying the energy characteristics of electric drives for the purpose of mathematical modeling of the dynamic operating modes of an electric vehicle drive. Research methods. Physical experiment, regression analysis, interpolation. Findings. A torque measuring unit has been developed as part of a laboratory complex for studying the energy characteristics of electric vehicle drives, the design of which allows creating a torque on the shaft of the engine under study using a load and measuring it with a strain gauge force sensor. The laboratory stand together with the developed torque measuring unit corresponds to the required range and measurement accuracy. The experimental data obtained at the test bench make it possible to determine the dependence of the energy consumed by the drive on the mechanical power on the shaft of the engine under study, which makes it possible to analytically describe the drive under study and carry out mathematical modeling in the context of studying the influence of mechanical parameters on the consumed energy in dynamic modes of operation. Originality. A method for measuring torque on the motor shaft for studying the energy characteristics of electric vehicle drives has been developed. This method is based on the contact method of measurement, which uses 2 motors (loading and testing) and strain gauge force sensor and differs from others in the design that creates a moment on the shaft of the test motor.The result of processing the experimental data obtained by this method is the analytical dependence of the energy consumed by the drive on the value of the mechanical power on the shaft, the parameters of which are the angular speed and torque of the engine. The specified energy characteristic of the drive makes it possible, by means of mathematical modeling, to determine the electromechanical parameters of the drive, minimizing its energy consumption in dynamic modes of operation. Practical value. A method for measuring the moment on the motor shaft is proposed, with the help of which the dependence of the energy consumed by the drive on the mechanical power on the motor shaft is determined in an analytical form, which allows by mathematical modeling to find the electromechanical parameters of the system that increase the energy efficiency of the drive of an electric vehicle.

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