Relevant bibliographies by topics / Complex biomaterials

Academic literature on the topic 'Complex biomaterials'

Author: Grafiati
Published: 7 July 2024
Last updated: 7 July 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Journal articles on the topic "Complex biomaterials":

1

Macnair, R., M. J. Underwood, and G. D. Angelini. "Biomaterials and cardiovascular devices." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 6 (June 1, 1998): 465–71. http://dx.doi.org/10.1243/0954411981534222.

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In the field of cardiovascular surgery there is presently a lack of biomaterials possessing essential characteristics of the native tissue or organ which is to be replaced. This paper describes various biomaterials that have been introduced into the circulatory system and the complex reactions that subsequently occur. The risk of infection is also discussed as well as prevention and treatment regimes that can be used. Examples of future biomaterial development are outlined in an attempt to achieve biocompatibility.
2

BALTATU, Madalina Simona, Petrica VIZUREANU, Andrei Victor SANDU, Iustinian BALTATU, Doru Dumitru BURDUHOS-NERGIS, and Marcelin BENCHEA. "PROSPECTS ON TITANIUM BIOMATERIALS." European Journal of Materials Science and Engineering 8, no. 4 (December 20, 2023): 201–12. http://dx.doi.org/10.36868/ejmse.2023.08.04.201.

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Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either a therapeutic or diagnostic one. Biomaterials have a rich history of evolution, as they have continuously transformed from simple inert substances to complex, interactive materials, designed to communicate with biological systems and promote tissue regeneration and healing. Titanium, due to its excellent biocompatibility, corrosion resistance, and mechanical properties, has established its place as one of the most used biomaterials, particularly in orthopedics and dental applications. This article provides an overview of titanium as a biomaterial, highlighting its properties, applications, and recent advancements.
3

Petković, Dušan, Miloš Madić, and Goran Radenković. "Knee Prosthesis Biomaterial Selection by Using MCDM Solver." Advanced Technologies & Materials 46, no. 2 (December 15, 2021): 37–41. http://dx.doi.org/10.24867/atm-2021-2-006.

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Biomaterials are a special class of contemporary materials used to make prostheses, parts of organs or to replace entire organs. They are used to replace soft and hard tissues. Metal biomaterials are mostly used to replace hard bone tissues and joints. There is no ideal substitution for natural biological material, but each of the biomaterials has a number of advantages and disadvantages. The problem of choosing the most favorable biomaterial is a complex process of multi‐criteria decision‐making, which requires a lot of knowledge and experience. In order to help decision makers in solving this complex task, a decision support system named MCDM Solver is proposed. MCDM Solver is used in decision‐making process to rank the biomaterials with respect to several criteria. In this paper, MCDM Solver was used to select knee prosthesis material.
4

Leeuwenburgh, Sander. "Self-healing biomaterials for medical applications." MATEC Web of Conferences 378 (2023): 01003. http://dx.doi.org/10.1051/matecconf/202337801003.

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Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties are required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing in order to improve the functionality of traditional biomaterials in terms of their mechanical, handling and biological properties. This presentation will provide a comprehensive overview of the field of self-healing biomaterials, ranging from self-healing of capsule-filled dental fillers and bone cements, to the self-healing behavior of modern injectable hydrogels used in regenerative medicine. More specifically, the presentation will highlight why self-healing properties of biomaterials are crucial for minimally invasive injection into the human body and achieve successful tissue regeneration.
5

Kim, Alexia, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat, and Michelle Griffin. "Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response." Bioengineering 10, no. 12 (December 11, 2023): 1411. http://dx.doi.org/10.3390/bioengineering10121411.

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Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the complex biomaterial–host cell interactions that occur within the tissue microenvironment is crucial for the development of therapeutic biomaterials that promote tissue integration and minimize the foreign body response. Recent modifications of specific material properties enhance the immunomodulatory capabilities of the biomaterial and actively aid in taming the immune response by tuning interactions with the surrounding microenvironment either directly or indirectly. By incorporating modifications that amplify anti-inflammatory and pro-regenerative mechanisms, biomaterials can be optimized to maximize their healing benefits in harmony with the host immune system.
6

Chow, Lesley W., and Jacob F. Fischer. "Creating biomaterials with spatially organized functionality." Experimental Biology and Medicine 241, no. 10 (May 2016): 1025–32. http://dx.doi.org/10.1177/1535370216648023.

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Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.
7

PRESTWICH, GLENN D., and HOWARD MATTHEW. "Hybrid, Composite, and Complex Biomaterials." Annals of the New York Academy of Sciences 961, no. 1 (June 2002): 106–8. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03058.x.

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Bettinger, Christopher J. "Synthesis and microfabrication of biomaterials for soft-tissue engineering." Pure and Applied Chemistry 81, no. 12 (October 31, 2009): 2183–201. http://dx.doi.org/10.1351/pac-con-09-07-10.

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Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections: (1) biomaterials synthesis, including elastomers and gels; (2) synthetic micro- and nanostructures for engineering the cell–biomaterial interface; and (3) complex biomaterials systems design for controlling aspects of the cellular microenvironment.
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Sask, Kyla N., Bruce Thong, Negar Goodarzynejad, Leslie R. Berry, and Anthony K. C. Chan. "Immunospecific analysis of in vitro and ex vivo surface-immobilized protein complex." Biointerphases 17, no. 2 (March 2022): 021005. http://dx.doi.org/10.1116/6.0001783.

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Biomaterials used for blood contacting devices are inherently thrombogenic. Antithrombotic agents can be used as surface modifiers on biomaterials to reduce thrombus formation on the surface and to maintain device efficacy. For quality control and to assess the effectiveness of immobilization strategies, it is necessary to quantify the surface-immobilized antithrombotic agent directly. There are limited methods that allow direct quantification on device surfaces such as catheters. In this study, an enzyme immunoassay (EIA) has been developed to measure the density of a synthetic antithrombin-heparin (ATH) covalent complex immobilized on a catheter surface. The distribution of the immobilized ATH was further characterized by an immunohistochemical assay. This analyte-specific EIA is relatively simple and has high throughput, thus providing a tool for quantitative analysis of biomaterial surface modifications. These methods may be further modified to evaluate plasma proteins adsorbed and immobilized on various biomaterial surfaces of complex shapes, with a range of bioactive functionalities, as well as to assess conformational changes of proteins using specific antibodies.
10

Honig, Floris, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, and Lidy E. Fratila-Apachitei. "Natural Architectures for Tissue Engineering and Regenerative Medicine." Journal of Functional Biomaterials 11, no. 3 (July 7, 2020): 47. http://dx.doi.org/10.3390/jfb11030047.

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The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the holy lotus with special wettability for self-cleaning effects. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses in vitro and provide greater insights into the processes occurring at the cell-biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces, with an emphasis on material properties known to affect cell behaviour.
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Journal articles

Dissertations / Theses on the topic "Complex biomaterials":

1

Petay, Margaux. "Multimodal and multiscale analysis of complex biomaterials : optimization and constraints of infrared nanospectroscopy measurements." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASF092.

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Dans le domaine du biomédical, l'étude des changements physico-chimiques induits par une pathologie au sein des tissus, à l'échelle cellulaire, peut être cruciale pour élucider les mécanismes à l'origine de ce phénomène. Toutefois, seules quelques techniques d'analyse permettent une description chimique à cette échelle. La nanospectroscopie infrarouge, en particulier l'AFM-IR (Microscopie à Force Atomique-Infrarouge) est prometteuse en permettant une description chimique des matériaux à l'échelle nanométrique. Actuellement, l'AFM-IR est souvent utilisée pour l'étude des cellules et micro-organismes, mais très peu pour l'étude des tissus biologiques en raison de la complexité de ces derniers. Pourtant, de nombreuses applications pourraient bénéficier d'une telle description, comme l'étude des phénomènes de minéralisation dans les tissus mammaires. Les microcalcifications mammaires (MCMs) sont des dépôts calciques anormaux (oxalates ou phosphates de calcium) et dont la composition est, dans la littérature, présumée associée à la nature des lésions : cancéreuses ou non. Malgré la multiplication des recherches sur le sujet au cours des dix dernières années, les processus de formation de ces MCMs et leur lien avec les pathologies et notamment les cancers du sein restent mal compris. Dans ce contexte, une description chimique des MCMs à l'échelle nanométrique pourrait fournir un nouvel éclairage et aider à la compréhension de leur genèse. Les biopsies mammaires (typiquement quelques millimètres à quelques centimètres) contiennent généralement plusieurs MCMs avec une forte dispersion en taille, de quelques centaines de nanomètres à un millimètre. Une stratégie de caractérisation multi-échelle est donc nécessaire pour décrire chimiquement l'entièreté de l'échantillon mais également accéder à une description fine des MCMs. Une approche multimodale et multi-échelle a ainsi été mise en place. Celle-ci permet d'étudier les propriétés morphologiques des MCMs en utilisant la microscopie électronique à balayage, ainsi que leurs propriétés chimiques à l'échelle micrométrique et nanométrique grâce à la microscopie et nanospectroscopie IR (e.g., AFM-IR). Bien que l'étude d'objets inorganiques et cristallins au sein d'une matrice organique par AFM-IR soit complexe, en raison des fortes variations locales des propriétés optiques et mécaniques au sein de ces matériaux hybrides, nous avons réussi à caractériser par AFM-IR des dépôts calciques au sein de tissus biologiques. La mise en œuvre d'une telle approche comporte plusieurs défis, tant d'un point de vue méthodologique qu'expérimental, notamment pour la préparation des échantillons, au cours des mesures, du traitement et de la gestion des données générées, ainsi que de leur interprétation. Tous ces aspects seront détaillés et des solutions proposées illustrant ainsi les capacités de l'AFM-IR pour l'étude des biomatériaux complexes
In the biomedical field, understanding the physicochemical changes at the cellular level in tissues can be crucial for unraveling the mechanisms of pathological phenomena. However, the number of techniques providing chemical descriptions at the cellular/molecular level is limited. Infrared (IR) nanospectroscopy techniques, particularly AFM-IR (Atomic Force Microscopy-infrared), are promising as they offer materials' chemical descriptions at the nanometer scale. Up to now, AFM-IR is mainly used in biology for studying individual cells or micro-organisms, but its direct application in biological tissues is relatively scarce due to tissue sections' complex nature. Yet, many applications could benefit from such description, such as mineralization phenomena in breast tissue. Breast microcalcifications (BMCs) are calcium-based deposits (such as calcium oxalate and calcium phosphate) hypothesized to be associated with some breast pathologies, including cancer. Despite increased research over the past decade, BMCs' formation process and connection with breast conditions remain poorly understood. Still, BMCs nanoscale chemical speciation might offer new insights into their chemical architecture. However, breast biopsies typically range from a few millimeters to a few centimeters, containing many BMCs ranging from hundreds of nanometers to a millimeter. Thus, a breast biopsy multiscale characterization strategy is required to provide both a global chemical description of the sample and a fine chemical description of BMCs. We, thus, propose a new multimodal and multiscale approach to investigate BMCs' morphological properties using scanning electron microscopy and their chemical composition at the microscale using IR spectromicroscopy, extending up to the nanometer scale thanks to AFM-IR analysis. Although AFM-IR measurements of inorganic and crystalline objects can be challenging due to their specific optical and mechanical properties, we demonstrate AFM-IR capabilities to characterize pathological deposits directly in biological tissues. Furthermore, implementing a multimodal and multiscale methodology comes with significant challenges in terms of sample preparation, measurements, data processing, and data management, as well as their interpretation: challenges which will be outlined and addressed
2

Hart, Kathryn Jacoba. "A RAPID PROTOTYPING METHOD FOR CONSTRUCTING A COMPLEX THREE-DIMENSIONAL SUBSTRATE." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/217.

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Cell culturing on three-dimensional structures has increased the possibilities in tissue engineering and bioreactor research. These structures enable cells to differentiate, proliferate, mobilize, and function in a conformation that more accurately mimics in vivo conditions. Computer generated models aid in development and rapid alteration of three-dimensional cell substrates, defining their internal structure as well as their external morphology. The rapid transition from substrate design to a viable culture is imperative to quickly advance research in biomedical and tissue engineering applications. The aim of this thesis is to investigate the feasibility of a rapid prototyping process by selectively cross-linking and assembling biocompatible films. This investigation revealed that selectively cross-linking and layering gelatin films could produce a three-dimensional substrate with a defined structure after dissolving uncross-linked gelatin. The study also revealed that freeze-drying aided in the rapid dissolution of uncross-linked gelatin. The line width resolution obtained during tests was .5 mm using a template treatment method and was limited by the template construction resolution. Finally, alteration in treatment time, rinsing agitation, and rinsing temperature yielded stable films that better retained their size and shape compared to films produced in previous processes.
3

Chavez, Robert Dalton. "Development of In Vitro Tissue Engineered Blood Vessel Mimics in Complex Geometries for Coronary Stent Testing." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/828.

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Coronary heart disease is the leading cause of death in the United States and occurs when plaque occludes coronary arteries. Coronary stents, which may be used to treat coronary occlusions, are small metal tubes that are implanted in coronary arteries to restore blood flow. After stent implantation, endothelial cells grow over the stent so that blood contacts the endothelial cells instead of the stent surface; this event is known as re-endothelialization. Re-endothelialization prevents blood from clotting on the stent surface and is a good predictor of stent success. Blood vessel mimics (BVMs) are in vitro tissue engineered models of human blood vessels that may be used to preclinically test coronary stents for re-endothelialization. BVMs have been developed in straight geometries, but the FDA has recommended that coronary devices be preclinically tested in complex-shaped simulated vessels when the complex geometries of coronary arteries may negatively affect device performance. Coronary geometries may negatively affect the tissue response to coronary stents, therefore BVMs should be developed in complex geometries. The goal of this thesis research was to fully develop complex-shaped scaffolds and bioreactors, to develop complex-shaped BVMs with cells located throughout all regions of the BVMs, and to develop a complex-shaped BVM with a confluent region of cells. First, bioreactors that can house complex-shaped scaffolds were designed, constructed, and validated. Complex-shaped BVMs were then developed by depositing cells throughout the entire inner surface of complex-shaped scaffolds, and the average and median cell densities throughout all regions of the BVMs were shown to be approximately the same order of magnitude as endothelial cell densities in native blood vessels. A stent was then successfully deployed in a complex-shaped BVM. The complex-shaped BVM straightened out to conform to the stent, which also occurs in native blood vessels. Finally, a confluent region of cells was developed on a complex-shaped scaffold. Complex-shaped BVMs could eventually be used to preclinically test coronary stents, coronary drug-delivery systems, coronary imaging modalities, and other intravascular technologies.
4

Gangolli, Riddhi Ajit. "A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/409954.

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Bioengineering
Ph.D.
60 % of school children have some form of untreated tooth decay or have suffered trauma to the front teeth which results in pulp damage. If left untreated, these teeth are susceptible to premature fracture/loss under daily stresses. In cases of adolescent tooth loss, teenagers cannot get dental implants until after the growth spurts; their only option is using removable dentures which lowers their quality of life. Conventional endodontic treatment (root canal treatment) is used in cases of pulp necrosis, but cannot be performed in immature permanent teeth due to major differences in tooth anatomy. Currently the American Dental Academy has approved a procedure called Regenerative Endodontic Treatment (RET) for such cases, but the outcomes are still unpredictable and the method is largely unreliable. One issue that we are trying to address in this work is the regeneration of the pulp-dentin complex (PDC), specifically the interface. Endeavors in regenerating either pulp or dentin have been successful individually, but the interface region is the anatomical and physiologic hallmark of the PDC and has not been addressed. We have proposed a biomimetic scaffold to facilitate early stage stratification of these different tissues and allow recapitulation of their interface. Tissue engineering principles and biomaterial processing techniques were used simultaneously to encourage dental pulp stem cells into mineralize selectively only on one side. This effectively allows the scaffold to serve as the interface region between the hard dentin and the soft vascular pulp.
Temple University--Theses
5

Lalevée, Gautier. "Complexes polyélectrolytes d'acide hyaluronique et de chitosane pour des applications biomédicales." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1075.

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Ce travail est consacré à l'élaboration de complexes polyélectrolytes combinant deux polyélectrolytes de charges opposées ainsi que l'étude de leur potentiel en tant que biomatériaux injectables pour du comblement de ride. L'acide hyaluronique (portant des - charges négatives sur ses groupements carboxyliques -COO ) a été complexé avec l'unique polycation d'origine naturelle appelé chitosane (portant des charges positives de + par ses groupements amines -NH3 ). Les paramètres influençant la formation et les propriétés physico-chimiques des complexes acide hyaluronique – chitosane ont été étudiés. Nous avons utilisé une nouvelle technique de complexation développée au laboratoire mettant en œuvre la diminution de la force ionique de mélanges acide hyaluronique – chitosane – chlorure de sodium par dialyse dans le domaine de complexation de l'acide hyaluronique et du chitosane (pH approximativement compris entre 2.5 et 6.5). Ce procédé permet l'élimination progressive des sels et une association lente. Nous avons par ce biais été capable d'induire et de contrôler l'auto-assemblage de ces deux polyélectrolytes. Plusieurs formes ont ainsi été obtenues comme des agrégats, des complexes solubles, des suspensions colloïdales ou des coacervats. Au cours de ce travail, nous avons obtenu des hydrogels mixtes d'acide hyaluronique et de chitosane ayant d'exceptionnelles propriétés d'étirabilité à pH acide. D'autre part, une approche alternative a été envisagée, visant à utiliser les propriétés intrinsèques du chitosane, en particulier son aptitude à gélifier au contact de milieux alcalins. Ainsi, par un procédé similaire, nous avons pu former des hydrogels acide hyaluronique – chitosane réticulés physiquement, stable à pH et osmolarité physiologiques, et pouvant endurer des déformations importantes. De plus, ces systèmes peuvent être stérilisés par autoclave et peuvent être formulés afin d'être injectables. Réunissant toutes les conditions pour être de bons candidats au développement de biomatériaux injectables, ces hydrogels ont été testés in vivo sur un modèle lapin afin d‘évaluer leur biocompatibilité et leur applicabilité en tant que produits injectables en intradermique
This work is devoted to the elaboration of polyelectrolyte complexes systems combining two oppositely-charged polyelectrolytes and to the study of their potential application as - injectable dermal fillers. Hyaluronic acid as polyanion (carboxylic groups -COO as negative charges) was complexed with the only naturally-occuring polycation named + chitosan (amine groups -NH3 as positive charges). The factors impacting the formation of hyaluronic acid - chitosan complexes and their physico-chemical properties were investigated. We used a new technique of complexation developed in the laboratory through the desalting of highly salted mixtures, and systematically investigated the impact of pH in the range 2.5 - 6.5, corresponding to the complexation domain of hyaluronic acid and chitosan. This process allowed the progressive elimination of the salts and the slow restoration of the attractive electrostatic interactions resp onsible for the self-assembly of the two polyelectrolytes. Various physical forms were obtained: macroscopic aggregates, soluble complexes, colloidal suspensions or hydrogels. During this work, we observed for the first time the formation of hyaluronic acid-chitosan hydrogels exhibiting a very unusual hyper-stretchability, only at acidic pH. Therefore, an alternate approach consisted in taking advantage of the chitosan ability to gel in alkaline medium. By using a similar process, we were then able to form physically-crosslinked hyaluronic acid-chitosan hydrogels stable at physiological pH and osmolarity and still able to undergo high deformations. Moreover, these systems could be submitted to steam sterilization and could be formulated so as to be injectable. Hence, these hydrogels gathered all the conditions to be good candidates as injectable biomaterials, these hydrogels were then tested in vivo on a rabbit model to evaluate their biocompatibility and suitability for intradermal applications
6

Tirado, Viloria Patricia Carolina. "New saloplastic biomaterials based on ultracentrifuged polyelectrolyte complexes." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAF034.

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Ce travail avait pour but de développer un nouveau type de matériaux basés sur des complexes polyelectrolytes. Ces matériaux ont été obtenus par l’ultracentrifugation des complexes soit d’origine naturelle ou soit d’origine synthétique. Le système de polyélectrolytes ainsi que les conditions dans lesquelles ces matériaux peuvent être obtenus, suivi par le choix du système optimal pour des études complémentaires ont été décrits. PAA / PAH CoPECs a été choisi comme systèmes modèles de synthèse et ses propriétés physico chimiques (composition, structure et les propriétés mécaniques) ont été décrits ici en détails. Nous avons montré que les propriétés de la composition, la structure et mécanique de le PAA/PAH CoPECs peut être contrôlée en modifiant les conditions d’assemblage (pH, concentration des polyélectrolytes, [NaCl], la vitesse et la commande de l’addition). Également, les conditions environnementales ([NaCl] et pH) ont également été utilisés pour contrôler la taille des pores et porosité des PAA/PAH CoPECs . Enfin, leur capacité à servir de support pour l’immobilisation d’enzymes a également été étudiée. Nous avons optimise les conditions d’assemblage afin de maintenir le maximum quantité de l’enzyme dans le complexe. Nous avons également démontré que CoPECs fournit la stabilisation à long terme, ainsi que la protection de l’enzyme à des températures élevées. Ainsi, PAA / PAH CoPECs sont des candidats potentiels pour être utilisé comme des supports pour l’ingénierie tissulaire et pour l’immobilisation d’enzymes
This work was aimed to the develop of a new kind of materials of polyelectrolytes complexes. These materials were obtained by the ultracentrifugation of complexes either of natural or synthetic origin. The polyelectrolytes systems as well as the conditions under which these materials could be obtained, followed by the selection of the optimal system to further studies was described. PAA/PAH CoPECs was chosen as synthetic model systems and its physiochemical properties (composition, structure and mechanical properties) were here deeply described. We demonstrated that the composition, structure and mechanical properties can be controlled by changing the assembly conditions (pH, concentration of the polyelectrolytes, [NaCl], speed and order of addition). Moreover, the environmental conditions ([NaCl] and pH) were also used to control the porosity and pores size of the PAA/PAH CoPECs. Finally their ability to serve as scaffold for enzyme immobilization was also studied. We optimized the assembly conditions to keep the maximum of the activity. We also demonstrated that the CoPECs structure provides the stabilization in long term as well as the protection of the enzyme from high temperature. Thus, PAA/PAH CoPECs is a potential and suitable candidates as scaffold for tissue engineering and for the immobilization of enzymes
7

Lints, Martin. "Optimised Signal Processing for Nonlinear Ultrasonic Nondestructive Testing of Complex Materials and Biological Tissues." Thesis, Bourges, INSA Centre Val de Loire, 2017. http://www.theses.fr/2017ISAB0001/document.

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Nous proposons l’innovation «TR-NEWS retardée» comme une extension des méthodes TR-NEWS,issues de la symbiose du retournement temporel (RT) et des méthodes de spectroscopie d’ondes élastiques non linéaires (NEWS), avec pour principales applications le contrôle non destructif (CND) et l’imagerie ultrasonore médicale. Nous confirmons expérimentalement les bonnes performances des méthodes TR-NEWS pour : (i) des échantillons de composite CFRP aux propriétés dispersives ultrasonores autour de 10 MHz, favorisant ainsi la réverbérabilité de la propagation acoustique; (ii) des mesures de propriétés non classiques de la peau porcine par une instrumentation multi-échelles acousto-mécanique élaborée dans le cadre du projet PLET(Propriétés Locales Visco-Élastiques de la peau par TR-NEWS) financé par la Région Centre Val de Loire. via les simulations numériques 1D pseudo spectrales de propagations acoustiques non linéaires dans les CFRP, nous identifions et localisons les sources locales de défauts et de microendommagements. Elles valident l’identification d’un crack unique proche de la zone de focalisation. La non linéarité supposée de type contact acoustique (CAN),mesurée par «TR-NEWS retardée»et comparée aux techniques classiques d’inversion d’impulsion utilisées en imagerie médicale, permet une identification préservant la représentation temporelle de l’information. Ainsi, ce système d’instrumentation acousto-mécanique envisage la mesure de paramètres multi-échelles de non linéarité des tissus biologiques via les paramètres de Preisach-Mayergoyz (espaces PM) permettant de décrire leur vieillissement. Le chargement basse fréquence uniaxial (0.1-10Hz) synchronisé aux caractérisations ultrasonores haute fréquence (20MHz) via «TR-NEWS retardé» suggère une nouvelle classe de dispositifs dotée d’une perspective de multimodalité dédiée à l’imagerie ultrasonore non invasive des propriétés biomécaniques des organismes vivants
In this thesis the possibility of nonlinear ultrasonic NDT is investigated for complex materials and biological tissues. The delayed TR-NEWS signal processing methodis developed, which is based on the TR-NEWS method. TR-NEWS is a method well-suited for materials with complex structure: it allows spatio-temporal focusing of a long ultrasonic chirp signal to the region near the receiving transducer, forming an impulse pulse. The received signal power and SNR are increased as a result.Delayed TR-NEWS allows the use of this focused wave pulse as a new basis for either the signal optimisation or, alternatively, for the detection of nonlinearity by the breakdown of linear superposition. This method is used in physical experiments and simulations. The physical experiments are made on an undamaged CFRP block and a porcine skin sample. The skin is tested in a synchronised acoustomechanical setup specially designed in the course of this thesis. In 1D pseudospectral simulations for CFRP, it is determined that while classical nonlinearity cannot probably be detected in ultrasonic NDT, it could be possible to detect nonclassical nonlinear effects such as those from cracks and microdamage.Physical experiments and 2D FEM simulations of linear, undamaged CFRP are compared for studying the delayed TR-NEWS method, its applicability in optimising the focused wave, and also for creating an interaction of waves at the focusing region with a linear superposition prediction. This suggests the possibility of detecting nonlinearities by comparing the actual signal from interaction to the linear prediction.Finally, more 2D simulations are conducted for CFRP with a single contact gap nonlinearity near the focusing region. The nonlinearity is measured by PI and delayed TR-NEWS. It is determined that delayed TR-NEWS is able to detect the defect at least as well as the PI method. It is ascertained that the PM hysteresis model could describe the nonclassical nonlinearity of damaged materials and biological tissues. Asynchronised acoustomechanical test setup is created to test such multiscale nonlinearity. The simultaneous mechanical load test and ultrasonic delayed TR-NEWS test can be used to measure the mechanical properties of skin
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BEOLCHI, RAFAEL da S. "Adicao de complexo vitaminico em duas bioceramicas e seu efeito na regeneracao ossea." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11529.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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He, Tao [Verfasser], and Jörg [Akademischer Betreuer] Hausdorf. "A three-dimensional muscle biomaterial complex in vitro organoid system: An autoinduction bone formation model / Tao He ; Betreuer: Jörg Hausdorf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1238016960/34.

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Hardy, Alexandre. "Biomatériaux fonctionnels à base de complexes de polyélectrolytes compactés de type chitosan/alginate : conception, caractérisation et premières évaluations biologiques." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF024/document.

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De nos jours, de nombreuses maladies chroniques telles que le cancer ou l’arthrose nécessitent encore de nouvelles modalités de traitement. Des biomatériaux naturels capables de véhiculer des substances actives font partie des solutions à cette problématique. Récemment, des travaux ont été menés sur un nouveau type de biomatériau, les Complexes de Polyélectrolytes Compacts (CoPEC). Dans le cadre de cette thèse, des CoPEC à base de polyélectrolytes biosourcés, le chitosan et l’alginate, fonctionnalisés avec la β-cyclodextrine (βCD) ont été formulés. Le CoPEC βCD-chitosan/alginate, non-cytotoxique, a présenté des propriétés anti-inflammatoires intrinsèques dans le cadre d’un modèle in vitro d’inflammation. De plus, ce CoPEC a présenté une capacité à contenir et relarguer deux substances actives hydrophobes modèles, le piroxicam et la prednisolone. Enfin, une stratégie d’inclusion de substances actives hydrophiles au sein du matériau a été mise en œuvre. Le nouveau CoPEC est prometteur car il peut exposer un effet anti-inflammatoire intrinsèque et d’autres effets thérapeutiques via l’inclusion de substances actives au sein des cyclodextrines
Nowadays, many chronic diseases, such as cancer or osteoarthritis, still need new modalities of treatment. Natural biomaterials able to convey active substances represent a solution to this problematic. Lately, several research works have been conducted on a new type of biomaterial named Compact Polyelectrolyte Complexes (CoPEC). As part of this thesis, CoPEC have been prepared from two biosourced polyelectrolytes, chitosan and alginate, functionalized with β-cyclodextrin (βCD). Through an in vitro inflammation model, the non-cytotoxic βCD-chitosan/alginate CoPEC has displayed intrinsic anti-inflammatory properties. Moreover, this CoPEC has demonstrated a capacity to host and release piroxicam and prednisolone, two model hydrophobic active substances. Finally, a strategy to include hydrophilic active substances into the material has been implemented.Thus, the newly CoPEC is promising because it can exhibit an intrinsic anti-inflammatory effect as well as other therapeutic effects through the inclusion of active substances into the cyclodextrins

Books on the topic "Complex biomaterials":

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De Vito, André, and Waldyr Romão Júnior. Manipulação dos biomateriais odontológicos diretos – guia prático visual – v. 1. Universidade Nove de Julho - Uninove, 2022. http://dx.doi.org/10.5585/2022.biomateriais1.

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Nesta obra é possível justificar a manipulação com base nas propriedades dos materiais. Os profissionais poderão compreender o porquê de a manipulação ideal acontecer de uma ou outra forma. Sob esse ponto de vista, este livro e inédito. Em nenhum outro a relação entre a teoria e a prática ficou tão bem estabelecida. Associamos ao texto um guia prático ilustrado que demonstra o passo a passo da manipulação de cada um dos biomateriais mais utilizados durante a rotina clínica. Portanto, será possível associar a teoria com a prática com o objetivo de instruir os profissionais da odontologia de forma completa, fazendo do exercício da profissão uma empolgante e compensadora experiência.

Book chapters on the topic "Complex biomaterials":

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Zhai, Xinyun, and Wenguang Liu. "Chapter 13. 3D-bioprinting for Engineering Complex Tissues and Vascularization." In Biomaterials Science Series, 339–59. Cambridge: Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839163975-00339.

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Jang, Woo Dong, Nobuhiro Nishiyama, and Kazunori Kataoka. "Preparation of Naphthalocyanine Dendrimer Loaded Polyion Complex Micelle for Photodynamic Therapy." In Advanced Biomaterials VII, 465–68. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.465.

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Li, Quan Li, Zhi Qing Chen, Guo Min Ou, Laikui Liu, H. B. Jiang, Quan Zeng, Gang Li, G. He, An Chun Mo, and Brian W. Darvell. "Biomimetic Synthesis of Apatite - Polyelectrolyte Complex (Chitosan - Phosphorylated Chitosan) Hydrogel as an Osteoblast Carrier." In Advanced Biomaterials VI, 75–78. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.75.

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Lee, Hyun Jung, Keun Hong Park, So Ra Park, and Byoung Hyun Min. "Chitosan/Heparin Polyelectrolyte Complex Nanoparticles (100~200nm) Covalently Bonded with PEI for Enhancement of Chondrogenic Phenotype." In Advanced Biomaterials VII, 329–32. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.329.

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Kim, Sung Won, Yun Sik Nam, Yeon Jin Min, Jong Ho Kim, Kwang Meyong Kim, Kui Won Choi, In Sup Noh, and Ik Chan Kwon. "Release Profile of a Model Protein Drug Depending on the Stability of Microspheres Based on Polyelectrolyte Complex." In Advanced Biomaterials VII, 505–8. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.505.

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Katsaras, J., T. A. Harroun, M. P. Nieh, M. Chakrapani, M. J. Watson, and V. A. Raghunathan. "Neutron Scattering from Biomaterials in Complex Sample Environments." In Neutron Scattering in Biology, 107–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-29111-3_7.

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Ganapathy, Hullathy Subban, Min Hee Woo, Yeong Soon Gal, and Kwon Taek Lim. "Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications." In Advanced Biomaterials VII, 489–92. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.489.

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Tilocca, Antonio. "Molecular Dynamics Methods for Modeling Complex Interactions in Biomaterials." In Methods in Molecular Biology, 285–301. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-388-2_18.

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López, Hugo F., Armando Saldívar, and P. Huang. "Development and Properties of ε-Martensite in Co-Cr-Mo Alloys for Biomaterials Applications." In Properties of Complex Inorganic Solids 2, 307–25. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1205-9_23.

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Song, Xia, and Jun Li. "Recent Advances in Polymer-Cyclodextrin Inclusion Complex-Based Supramolecular Hydrogel for Biomedical Applications." In Springer Series in Biomaterials Science and Engineering, 141–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57511-6_7.

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Conference papers on the topic "Complex biomaterials":

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Mahmoud, Rahmatul, Quang Nguyen, Gordon Christopher, and Paul F. Egan. "3D Printed Food Design and Fabrication Approach for Manufacturability, Rheology, and Nutrition Trade-Offs." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-70663.

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Abstract 3D printing enables the production of personalized designs that are desirable in the medical industry for applications including orthopedics, tissue engineering, and personalized nutrition. Currently, the design process relies on trial-and-error approaches, especially for biomaterial development, and there is a need for methodologies to streamline the design process to facilitate automation. Here, we investigate a design methodology for printing foods by mixing novel biomaterial combinations informed by rheological measurements that indicate printability. The process consists of first printing basic designs with chocolate, marzipan, and potato biomaterials known to print consistently. Rheological measurements are collected for these materials and compared to a novel pumpkin biomaterial. The pumpkin had a higher complex modulus and lower mechanical loss tangent than all other biomaterials, therefore motivating the addition of rheological agents to reach more favorable properties. Varied concentrations of corn starch and guar gum were added to the pumpkin to improve printability while altering the nutrient distribution. A 4% inclusion of guar gum provided the most consistent pumpkin prints. A complex 3D object was fabricated with the 4% guar gum pumpkin material, therefore demonstrating the merits in using rheological properties to inform printability for use in design automation routines. The design approach enabled comparisons of relative nutrition and printability trade-offs to demonstrate a proof-of-concept user interface for design automation to facilitate customized food production. Further research to develop a complete design methodology for linking rheological properties to printability would promote consistent prediction of print quality for novel formulations to support design automation, with potential generalizability for diverse biomaterials.
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Narag, Jadze P. C., Nayere Taebnia, Rujing Zhang, Thomas L. Andresen, Niels B. Larsen, and Emil B. Kromann. "Imaging complex organ-on-chip systems." In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and Christoph K. Hitzenberger. SPIE, 2021. http://dx.doi.org/10.1117/12.2593200.

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Narag, Jadze P. C., Nayere Taebnia, Rujing Zhang, Thomas L. Andresen, Niels B. Larsen, and Emil B. Kromann. "Imaging complex organ-on-chip systems." In Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, edited by Pietro Ferraro, Monika Ritsch-Marte, Simonetta Grilli, and Christoph K. Hitzenberger. SPIE, 2021. http://dx.doi.org/10.1117/12.2593243.

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Kawabe, Yutaka, Yuki Suzuki, Kento Okoshi, and Takuya Tanaka. "Induced circular dichroism and laser action of hemicyanine dyes coupled to DNA and DNA-complex." In Optical Materials and Biomaterials in Security and Defence Systems Technology, edited by Roberto Zamboni, François Kajzar, Attila A. Szep, and Katarzyna Matczyszyn. SPIE, 2017. http://dx.doi.org/10.1117/12.2277394.

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Kawabe, Yutaka, and Kento Okoshi. "Light amplification and photo-isomerization characteristics of laser dyes and azo molecules incorporated into DNA-complex systems." In Optical Materials and Biomaterials in Security and Defence Systems Technology, edited by Roberto Zamboni, François Kajzar, Attila A. Szep, and Katarzyna Matczyszyn. SPIE, 2018. http://dx.doi.org/10.1117/12.2325290.

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Fee, Timothy J., and Joel L. Berry. "Mechanics of Electrospun Polycaprolactone Nanofibers." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80297.

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Electrospun biomaterials are gaining popularity as scaffolding for engineered tissues. This fibrous scaffolding of natural or synthetic polymers can mimic properties of the natural extra-cellular matrix. Moreover, undifferentiated cells seeded onto and within an electrospun matrix may be directed to differentiate into a desired tissue type through the application of the appropriate biochemical and mechanical conditions. It is becoming clear that the mechanical deformation of any electrospun matrix plays an important role in cell signaling. However, electrospun biomaterials have inherently complex geometries due to the random deposition of fibers during the electrospinning process. Even “aligned” electrospun matrices generate off-axis forces under load. This complex fiber geometry complicates any attempt at quantifying forces exerted on adherent cells during electrospun matrix deformation.
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Ghosh, Soham, J. Craig Dutton, and Bumsoo Han. "Spatiotemporal Intracellular Deformation of Cells During Freezing-Induced Cell-Fluid-Matrix Interactions." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14673.

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Freezing of biomaterials is emerging as one of the key biotechnologies in cell/tissue engineering, medicine and biology. Its applications include — 1) preservation of cell/tissue engineering products, 2) quality control of biospecimens cryopreserved in tissue banks and repositories, and 3) synthesis procedures of biomaterials such as decellularization of native tissues to create acellular (i.e., cell-free) complex three-dimensional extracellular matrices (ECMs). Traditionally, research efforts have focused on determining optimal freeze/thaw (F/T) protocols with chemical additives, so called cryoprotective agents, for a given cell/tissue-type by comparing the outcomes of F/T protocols, which are mainly gauged by cell viability. Although cell viability is the major constituent, it has recently been recognized that other features beyond viability are also critical to the functionality of biomaterials, including the microstructure of the ECM, the status of cell-matrix adhesion, and the cytoskeletal structure and organization [1, 2, 3].
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Kharel, Prabhuti, Likitha Somasekhar, Kevin Fernando, and Kunal Mitra. "Self-Contained 3D Bioprinter for Cardiovascular and Cancer Research." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3302.

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Bioprinting is a 3D fabrication technology used to accurately dispense cell-laden biomaterials for the fabrication of complex 3D functional living tissues. A syringe-based extrusion (SBE) deposition method comprising of multiple nozzles is integrated into the system. This allows for a wider selection of biomaterials that can be used for the formation of the extracellular matrix (ECM). The 3D bioprinting system presented in this paper aims to facilitate the process of 3D bioprinting through its ability to control the environmental parameters within an enclosed printing chamber. The primary objective of this research is to print viable 3D tissue constructs seeded with cells with high structural integrity and high resolution.
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Gevaert, Matthew R., Martine LaBerge, Jennifer M. Gordon, and John D. DesJardins. "The Quantification of Physiologically Relevant Cross Shear Wear Phenomena on Orthopaedic Bearing Materials Using a Novel Wear Testing Machine." In ASME/STLE 2004 International Joint Tribology Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/trib2004-64150.

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Background: Multi-directional sliding motions between total knee replacement materials is a suspected primary wear mechanism of ultra-high molecular weight poly(ethylene) (UHMWPE). Method of Approach: A wear testing machine was developed to quantify damage from crossing contact pathways on candidate biomaterials. A cyclic five-pointed star pattern was used to evaluate the tribological differences between linear and cross-motion surface tribology of stainless steel pins on flat UHMWPE. Results: Volumetric reconstruction of resultant damage showed that cross-shear volume loss was 2.94(± 0.88) times that of linear loss during testing. Conclusions: Basic multi-axis, cross-shear wear testing provides quantifiable measures of complex biomaterials wear phenomena.
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Han, Bumsoo, Jeffrey D. Miller, and Jun K. Jung. "Freezing Induced Microstructural Change of Collagen Matrix." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175251.

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Freezing of biological tissue occurs in many modern biomedical applications. These include cryosurgery for cancer, cryoablation for cardiac arrhythmia, cryoplasty for restenosis, and cryopreservation of native and engineered biomaterials. While the short-term success of these applications depends on the cellular viability — low viability for the therapeutic applications, and high viability for the preservation applications, the long-term success is determined by whether the functional properties of tissue are controlled as well as the viability. This becomes more important as the freezing-based technologies begin to be applied to larger and more complex biomaterials. However, the effects of freezing on these functional properties are rarely understood. Although several studies have been done on the freezing-induced change of the mechanical properties, the results are highly tissue-type dependent and the underlying biophysical mechanisms are poorly understood. Since the functional properties are associated with or often determined by the microstructural characteristics of the extracellular matrix (ECM), it is hypothesized that freezing-induced changes on the ECM microstructure affect the post-thaw functional properties. Thus, in this study, microstructural changes of collagen matrix were investigated using scanning electron microscopy and image analysis.

To the bibliography