Dissertations / Theses on the topic 'Compartimenter'
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El, Housseini Wassim. "Réacteur biomimétique : compartimenter et coupler la régénération du cofacteur NAD(P)H et l’oxydation biocatalytique de l’hydrogène." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0160.
The regeneration of cofactors NADH and NADPH is an important topic in biotechnology because many redox enzymes, such as alcohol dehydrogenases, imine reductases, and P450 monooxgenases, require cofactor to deliver their redox equivalent. However, because cofactors are particularly expensive, supplying stoichiometric cofactor when these enzymes are used in chemical synthesis is not economically feasible. To address this issue, a number of cofactor regeneration systems have been developed. Traditional regeneration systems for reduced cofactors have drawbacks because most of them require a carbon-based sacrificial co-substrate reductant and produce a by-product that is likely to be burned as waste, impeding downstream product purification and lowering the atom economy.In this work, the implementation of redox biocatalysis in a flow reactor coupling separately hydrogen oxidation to NADH regeneration was developed. A hierarchization of the work was important in order to proceed with an efficient regeneration of NADH.First, in a redox flow bioreactor hybridized by a gas diffusion electrode for hydrogen oxidation, the electrochemically mediated regeneration of NADH by a dissolved Rhodium complex ([Cp*Rh(bpy)Cl]+) was implemented. Initially, the reactor was optimized in terms of concentrations of rhodium complex and NAD+ ([NAD+]/[Cp*Rh(bpy)Cl]+ = 40), the non-humidification of hydrogen gas, the flow rates of H2 gas and electrolytic solution (20 mL.min-1), and the pH of the solution (7.2).Secondly, in order to promote the best cycling of both the catalyst and the enzymatic cofactor and potentially easier purification of the synthesized molecules, the immobilization of the rhodium complex was proceeded on a carbon paper coated with MWCNT (Rh@CP-MWCNT). Rh@CP-MWCNT electrode was shown to be stable for periods of more than 5 days under flow conditions. Following that, the cofactor regeneration technique was applied to NADH-dependent biosynthesis using L-lactate dehydrogenase (LDH): the enzyme was immobilized on a separate layer placed approximately 50 µm from the Rh-CP-MWCNT matrix, and used in the flow cell. A cofactor concentration as low as 10 µM was found to be sufficient for the conversion of pyruvate with high faradaic efficiency (78 %) and total turnover number (TTN) levels of 1.8*104, 2.5*103, and 1.8*105 for the Rh complex, the NADH cofactor, and the LDH enzyme, respectively.On the other hand, to expand the study, chemical catalysts were exchanged by biological ones. FNR, Ferredoxin NADP+ reductase, replaced the Rh complex at the cathodic compartment
Amestoy, Torre Élida. "Hipertensión intraabdominal secundaria a la resucitación en el shock." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405522.
Intra-abdominal pressure (IAP) is the pressure within the abdominal cavity. Increased IAP or intra-abdominal hypertension (IAH) in pa=ents with abdominal pathology has been known for more than a century, however, secondary IAH developed aBer resuscita=on with volume in pa=ents with shock is s=ll unknown. The exchange of gases, water and solutes between the intravascular fluid compartments and the inters==al fluid takes place mainly through the capillaries. The structure of the capillaries varies from one =ssue to another and therefore not all have the same permeability. In normal condi=ons, the endothelial membrane is rela=vely waterproof, but when something injures as sepsis, the endothelial cell changes from a quiescent phenotype (an=coagulant, an=adhesive, vasodilator), to an ac=vated phenotype (procoagulant, proadhesive and vasoconstrictor). This phenomenon causes an excessive vascular permeability, increase the liquid movement to the inters==al space and therefore secondary IAH. This situa=on is aggravated by the resuscita=on volume that is required in pa=ents with shock who are admiHed in the Intensive Care Units. We conducted a prospec=ve observa=onal study for 21 months in pa=ents who were admiHed for hemorrhagic hypovolemic shock, non hemorrhagic hypovolemic shock, and distribu=ve shock requiring resuscita=on volume. We assessed the type of shock, the presence of associated abdominal pathology at the =me of admission, total fluid volume administered, fluid losses and balance during the first 7 days of admission, IAP as the main variable collected during the first two days every 6 hours and aBer that collected as the highest IAP value over the day, hemodynamic variables that describe the shock, variables describing the different organic dysfunc=ons (respiratory, abdominal, renal, abdominal), ICU/hospital length of stays and mortality. We included 106 pa=ents in the study. According to the analyzed variables and the results obtained by the appropriate mul=variate analysis, we obtained the following results. The independent factors associated with the development of IAH in pa=ents with shock are the presence of abdominal pathology at admission and the total volume of fluids administered. The incidence of secondary IAH due to resuscita=on with volume in pa=ents with shock is 89,7% and the incidence of abdominal compartment syndrome (ACS) is 1,9%. The day of highest IAH value is the third. The IAH in pa=ents with shock of abdominal origin is greater than pa=ents who are admiHed due to shock from another source. The volume of cumula=ve third-day resuscita=on that best predicts the development of IAH is 7681 mL and the volume that best predicts the development of IAH grade III, pa=ents who are suscep=ble to develop ACS, is 18743 mL. The IAH correlates with ICU stay and overall hospital stay. The independent factor associated with the development of IAH in pa=ents with sep=c shock and abdominal origin is the volume of accumulated crystalloids during the first three days. We conclude that the incidence of secondary IAH to fluid resuscita=on is high. This resuscita=on received during the first three days of admission to the ICU of pa=ents admiHed for hypovolemic hemorrhagic shock, non hemorrhagic hypovolemic shock and sep=c shock with abdominal pathology should be performed with hemodynamic monitoring to diagnose early IAH, avoid and/or treat ACS and decrease hospital stays.
Guimaraes, Eder Cardoso. "AVALIAÇÃO DOS NÍVEIS BASAIS DE MERCÚRIO NA ÁREA DE INFLUÊNCIA DA UHE JIRAU RIO MADEIRA / AMAZÔNIA." Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/3129.
The hydrobiogeochemical cycle of mercury contemplates the natural and artificial sources of the metal, as well as the biotic and abiotic processes that occur in the distinct reservoirs and that they determine the transport and setting of the metallic forms in some final receiver. The process of methylation of mercury has deserved special attention in natural and artificial reservoirs in the Amazon region which had the raised toxic of the methylmercury for the human beings and animal, had the bioaccumulates in the aquatic alimentary chain. The present study it deals with the evaluation of total mercury and methylmercury natural levels in biotic and abiotic compartments of the basin of the river Mutum Paraná in the area of influence of the UHE - Jirau in the hidrography basin of the Madeira river. The values of total mercury in the water samples had been slow the 6,5 ng L-1, being approximately 150 lesser times that the values praised for the Ministry the Health for the human consumption, and the levels of the 0,3 methylmercury had been inferior ng L-1. The total mercury texts in the sediment of deep had presented values in the bands of 170+47 - 294+88 μg kg-1 whereas the texts of methylmercury the band of 0,84+0,25 - 1,40+0,35 μg kg-1, being the organic mercury fraction in the sediment in approximately 0.45% of the total mercury supply. The texts of total mercury in plankton and invertebrates had respectively presented values in the bands of 143+24 - 277+25 μg kg-1 and 191+25 - 323+45 μg kg-1, whereas the texts of methylmercury in the band of 4,41+1,22 - 9,76+0,67 μg kg-1 and 16,74+2,57 - 23,99+2,34 μg kg-1 respectively, evidencing the trend of the process of accumulation in the inferior levels of the eutrophic chain. The samples of ichthyofauna of consumption relevant in the traditional population of the study region had presented values of total mercury in the band of 0,06+0,19 - 0,12+0,04 mg kg-1 for the herbivores and omnivorous specimens and 0,28+0,5 0,40+0,1 mg kg-1 for the carnivorous specimens having evidenced the process of bioaccumulation and biomagnification in ichthyofauna. The values of the levels of the species of total methylmercury and methylmercury in the abiotics samples and bioptics had not evidenced points of diffuse contamination.
O ciclo hidrobiogeoquímico do mercúrio contempla as fontes naturais e antrópicas do metal, bem como os processos bióticos e abióticos que ocorrem nos distintos reservatórios e que determinam o transporte e fixação das formas metálicas em algum receptor final. O processo de metilação do mercúrio tem merecido especial atenção em reservatórios naturais e artificiais na região Amazônica devido a elevada toxicidade do metilmercúrio para os seres humanos e animais, devido a bioacumulação e biomagnificação na cadeia alimentar aquática. O presente estudo trata da avaliação dos níveis basais de mercúrio total e metilmercúrio em compartimentos bióticos e abiótico da bacia do rio Mutum Paraná na área de influência da UHE Jirau na bacia hidrográfica do rio Madeira. Os valores de mercúrio total nas amostras de água foram inferiores a 6,5 ng L-1, sendo aproximadamente 150 vezes menores que os valores preconizados pelo Ministério a Saúde para o consumo humano, e os níveis de metilmercúrio foram inferiores a 0,3 ng L-1. Os teores de mercúrio total no sedimento de fundo apresentaram valores nas faixas de 170+47 a 294+88 μg Kg-1 enquanto que os teores de metilmercúrio na faixa de 0,84+0,25 a 1,40+0,35 μg Kg-1, estando a fração de mercúrio orgânico no sedimento em aproximadamente 0,45% do estoque de mercúrio total. Os teores de mercúrio total no plâncton e invertebrados apresentaram valores nas faixas de 143+24 a 277+25 μg Kg-1 e 191+25 a 323+45 μg Kg-1 respectivamente, enquanto que os teores de metilmercúrio na faixa de 4,41+1,22 a 9,76+0,67 μg Kg-1 e 16,74+2,57 a 23,99+2,34 μg Kg-1 respectivamente, evidenciando a tendência do processo de acumulação nos níveis inferiores da cadeia eutrófica. As amostras de ictiofauna de relevante consumo na população tradicional da região de estudo apresentaram valores de mercúrio total na faixa de 0,06+0,19 a 0,12+0,04 mg Kg-1 para os espécimes herbívoras e onívoras e 0,28+0,5 a 0,42+0,1 mg Kg-1 para as espécimes carnívoras evidenciando o processo de bioacumulação e biomagnificação na ictiofauna. Os valores dos níveis das espécies de mercúrio total e metilmercúrio nas amostras abióticas e bióticas não evidenciaram pontos de contaminação difusa.
Lacour, Stéphanie. "Modélisation de feux compartimentés." Aix-Marseille 1, 1998. http://www.theses.fr/1998AIX11075.
Correa, Vazquez Eva Alicia. "SÍndrome compartimental crónico del antebrazo." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670457.
El Síndrome Compartimental Crónico del Antebrazo es una patología poco frecuente y que históricamente su estudio se ha centrado sobre todo en la afectación de los miembros inferiores. El diagnóstico de la misma es de base clínica y se apoya en la realización de mediciones dinámicas de la presión en los compartimentos afectados. Esta tesis desarrolla el estudio de la variable TRest como valor diagnóstico de las mediciones de presión intracompartimental dinámica. Así mismo revisa la precisión de los actuales valores diagnósticos de presión intracompartimental para el Síndrome Compartimental Crónico del Antebrazo y propone la optimización de los mismos. El tratamiento se basa en la descompresión quirúrgica de los compartimentos del antebrazo afectados y en nuestro estudio desarrollamos la comparación entre dos técnicas quirúrgicas, la cirugía abierta y la técnica mini-open.
Exertional Chronic Compartment Forearm Syndrome is a rare disease and historically its study has focused mainly on lower limbs. The diagnosis is primarly clinical but supported by dynamic measurements of intracompartmental pressure. This thesis develops the study of a new variable, the TRest as a diagnostic value of dynamic intracompartmental pressure measurements. It also stimates the accuracy of current intracompartmental pressure diagnostic values for Exertional Chronic Compartment Forearm Syndrome and proposes their optimization. The treatment is based on surgical decompression of the affected forearm compartments. In our study we compare two surgical techniques, open surgery and mini-open technique.
Francelin, Carolina 1985. "Estudo dos compartimentos linfóide e estromal do microambiente tímico em camundongos com diabetes experimentalmente induzido pelo Aloxana = Study of lymphoid and stromal compartiments of the thymic microenvironment in experimentally induced diabetes." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316962.
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O timo é o órgão linfoide primário responsável pela geração de linfócitos T maduros. Para que isso ocorra, células precursoras de linfócitos T, provenientes da medula óssea, entram no timo e migram constantemente através do microambiente tímico ¿ o qual é composto por componentes linfoides e não linfoides. Esta migração intratímica é fundamental para que os precursores das células T encontrem os sinais necessários para sobrevivência, proliferação, diferenciação e geração de diversidade de repertório. Assim como os outros órgãos linfoides, o timo está sujeito a um rígido controle neuroendócrino, o qual impõe consequências diretas sobre o funcionamento do sistema imunológico através de neurotransmissores, hormônios e citocinas. Entretanto, ainda é pouco o que se sabe sobre as interações entre os componentes do timo e hormônios do eixo HPA. Neste trabalho, foram avaliados os compartimentos linfoide e estromal na atrofia tímica observada no modelo experimental da diabetes tipo I. Nesse estudo foi observado que camundongos diabéticos apresentaram redução nos níveis séricos e intratímicos de leptina e elevados níveis séricos e intratímicos de corticosteroide, acompanhando a queda dos níveis séricos de insulina. Diante das alterações hormonais, nós observamos: modificações nos componentes linfoides e estromais do timo, caracterizadas por redução no número de timócitos, aumento na secreção de elementos de matriz extracelular, contração da porção cortical do timo acompanhada por acúmulo de linfócitos no estágio pré - seleção positiva, aumento da apoptose de células epiteliais tímicas e timócitos e aumento na exportação de células T imaturas para os órgãos linfoides secundários. Sucintamente, após o estabelecimento da hiperglicemia e ausência de insulina circulante, o timo de animais diabéticos apresentou alterações morfológicas e em todos os tipos celulares e fatores solúveis que compõe o estroma tímico, culminando em alterações nas células presentes na periferia do sistema imune. Acreditamos que os dados gerados nesse estudo contribuem, s.m.j., para um melhor entendimento da deficiência na resposta imune em indivíduos diabéticos e do desenvolvimento do linfócito T na ausência de insulina
Abstract: Thymus is the primary lymphoid organ responsible for the generation of T lymphocytes. For this to occur, precursor cells of T lymphocytes from bone marrow enter the thymus and migrate continuously through the thymic microenvironment - which consists of lymphoid and non-lymphoid components. This intrathymic migration is essential for T cell precursors get contact with signs that promote survival, proliferation, differentiation and generation of diversity of repertoire. Like other lymphoid organs, the thymus is subject to a rigid neuro-endocrine control, which requires direct consequences on the functioning of the immune system through neurotransmitters, hormones and cytokines. However, it is still little known about the interactions between the components of thymus hormones and the HPA axis. In this study, we evaluated the alterations in lymphoid and stromal thymic compartiments in thymic atrophy during experimental model of diabetes type I. Here in, we found that diabetic mice exhibit a reduction in serum aand intrathymic levels of leptin yet, intrathymic and serum corticosteroid levels were high, followed by a drop in serum insulin levels. Given the hormonal changes, we observed: changes in lymphoid and non-lymphoid component of the thymus, characterized by reduction in the number of thymocytes, increased secretion of extracellular matrix elements, contraction of the cortical portion of the thymus accompanied by accumulation of lymphocytes in the pre stage - positive selection, increased apoptosis of thymic epithelial cells and thymocytes and increase in export of immature T cells to secondary lymphoid organs. Briefly, after the onset of hyperglycemia and lack of circulating insulin, thymus in diabetic animals showed alterations in all cell types that comprise the thymic microenvironment, resulting in abnormal cells present in the periphery of the immune system. We believe that the data generated in this study will contribute to a better understanding of the immune deficiency in diabetic individuals and the development of T lymphocytes in the absence of insulin response
Doutorado
Imunologia
Doutora em Genética e Biologia Molecular
Boussac, Muriel. "Etudes protéomiques de compartiments de la voie endocytaire." Université Joseph Fourier (Grenoble), 2001. http://www.theses.fr/2001GRE10221.
Morel, Olivier. "Génération de microparticules procoagulantes dans le compartiment vasculaire." Paris 7, 2007. http://www.theses.fr/2007PA077224.
Procoagulant circulating MPs constitute valuable hallmarks of vascular cell damage that support cellular cross-talk leading to vascular inflammation, endothelial dysfunction, and tissue remodeling. In acute myocardial infarction, elevated levels of platelet and endothelial-derived MPs were evidenced in diabetics. An early decrease of procoagulant MPs levels was observed in patients treated by abciximab or by vitamin C. Within the coronary vasculature, whereas no link between CRP and plaque morphology could be established, CRP levels correlated with CD31+-MPs, a probe of endothelial cell apoptosis. The higher procoagulant MPs levels measured downstream the tightest lesions could contribute to their destabilization through multiple pathways including enhanced thrombogenicity and altered vasomotion. In pulmonary arterial hypertension, endothelium damage, and trans-tissular procoagulant MPs gradient appear related to the severity of the disease. Within the lung, trapped MPs could support thrombus formation and the raise of arterial pulmonary pressure. In heart transplanted patients, the pattern of procoagulant MPs released during acute allograft rejection testify to enhance endothelial cell activation and Fas-mediated apoptosis. E-selectin bearing MPs appeared an: independent marker of acute allograft rejection still informative after adjustment for graftcharacteristics. Altogether, in cardiovascular diseases, circulating MPs appear a useful tool for the identification of high risk patients. Pharmacological strategies aimed at modulating the release of procoagulant MPs and related noxious properties appear a promising therapeutic approach
Arnauld, Elisabeth. "Compartiment caudal du striatum : particularités neurochimiques et fonctionnelles." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M107.
Silva, Ana Claudia Machado. "Cinética e dosimetria do [177Lu-DOTA0, Tyr3]octreotato em pacientes com tumores carcinoides." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29102014-130657/.
Carcinoid tumors (well differentiated neoplasms) are neuroendocrine tumors that may arise in different anatomical locations. The population prevalence of carcinoid tumors is approximately 10 cases per one million inhabitants. Its incidence is higher in the fifth and sixth decade of life. This paper proposes a kinetic model in humans with carcinoid tumors who will underwent treatment with the radiopharmaceutical [177Lu-DOTA0,Tyr3 ]OCTREOTATE based on the theory of compartmental analysis. Dynamic planar scintigraphic images acquired immediately upon injection of 370 MBq (10 mCi) of the radiopharmaceutical were obtained with the SPECT (Single Photon Emission Computed Tomography) tomography. Samples from regions of interest (ROI) were used for the kinetic study applying the kinetic proposed model. The first phase of the study (activity 370 MBq) was aimed to evaluate the kinetic parameters. Subsequently, the patient underwent the [177Lu-DOTA0,Tyr3 ]OCTREOTATE radiotherapy protocol, under the physician\'s prescription (up to four cycles of 7.4 GBq (200 mCi)). Thus, it was possible to previously estimate the kinetic constants ki,j relative to biodistribution of [177Lu-DOTA0,Tyr3 ]OCTREOTATE in the body. The ki,j is the transfer fraction from the ith compartment (a tissue or an organ) to the jth compartment. Only few organs showed significant ROI radioactivity count level, among them: the liver, kidney, blood and carcinoid tumors. The MIRD method and the kinetic constants ki,j were used to estimate the absorbed dose in 26 body organs. The absorbed dose D(mGy/MBq) was comparable to other methods described in the literature. For an adult patient of 73.6 kg, on average, the kidneys (without amino acid protectors) showed the highest dose (2.39 mGy/MBq) followed by liver (0.70 mGy / MBq) and tumor (0.52 mGy/MBq) with a tissue size of approximately 100 g. It was observed that tumors receive the same absorbed dose D(mGy/MBq) regardless their position in the body. This finding is due to the predominance of the tissue radiation damage of beta particles compared to gamma radiation that has little yield emission in the 177Lu decay scheme. Therefore, the kinetic parameters ki,j that promote the uptake of 177Lu in cells are primarily responsible for the absorbed D dose in the tumor and other organs.
Solanich, Valldaura Teresa. "Síndrome compartimental abdominal en aneurismas de aorta abdominal rotos." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/665385.
Introduction: Ruptured abdominal aortic aneurysms (RAAA) carry a high mortality. Patients who survive surgery have mortality rates of 32 to 80%1-4). Multi-organ failure during the immediate postoperative period is a very common cause of death. Abdominal compartment syndrome (ACS) is present in 30-53% of cases and represents a frequent cause of multi-organ failure with both endovascular and open inter-ventions, which accounts for 70% of deaths (3). ACS is an independent predictor of mortality in RAAA and its prevention, detection and treatment with decompressive laparotomy can increase survival. The aim of the present study was to analyse 30-day survival of patients undergoing RAAA repair, the presence of risk factors for ACS and RAAA and the results obtained with delayed abdominal closure. Material and methods: A retrospective observational study was designed, with the inclusion of patients undergoing RAAA repair between 2002 and 2016 in the Angiology and Vascular Surgery service, at the Hospital Uni-versitari Parc Taulí. RAAA was defined as the extravasation of blood or haematoma outside the wall of the abdominal aortic aneurysm (AAA) in computed tomography (CT) angiography and/or evidence of haematoma outside the AAA during the surgery. The presence of ACS was established according to the parameters established by the WSACS or when primary abdominal closure could not be performed at the discretion of the vascular surgeon. Demographic variables, type of surgery, delayed abdominal closure, pre-, intra- and postoperative ACS risk factors and 30-day survival were collected. Results: A total of 61 patients were included out 85 eligible: 39 open and 22 endovascular surgeries.Patient not submitted to repair were excluded. Overall intra- and postoperative mortality was 54% (66.7% with open surgery and 31.8% with endovascular surgery (p=0.009)). The postoperative results of 43 patients who survived surgery were analysed: 21 (48.8%) with open surgery and 22 (51.2%) with endovascular surgery. Overall 30-day postoperative survival was 67.4% (61.9% with open surgery and 72.7 with endovascular surgery). The most frequent risk factors for abdominal compartment syndrome were: perfusion >5 litres, coag-ulopathy, transfusion > 6 units of packed red blood cells and metabolic acidosis. In the open surgery group: 12 presented ACS, 4 of which died, and 4 of the 9 patients who did not present ACS died (p=0.604). In the endovascular surgery group, 6 patients presented ACS, 4 of which died, and 3 of the 6 patients who did not present ACS died (p=0.032). Of the patients who underwent OS, the abdomen was left open in 9 cases (42.86%), and primary abdominal closure was performed in 12. Delayed abdominal closure increased survival (88.9% vs. 41.7%). Six patients in the endovascular group had decompressive laparotomy during the same sur-gical procedure. Decompressive laparotomy did not increase survival in the endovascular surgery group (42.9% vs. 87.5%). Conclusions: Abdominal compartment syndrome did not increase mortality in the open surgery group. Abdominal compartment syndrome increased mortality in the endovascular surgery group. Intraoperative mortality of RAAA was higher in the open surgery group. We did not detect differences in postoperative mortality of RAAA according to the type of surgery. The risk factors for abdominal compartment syndrome were: perfusion >5 litres, coagulopathy, trans-fusion >6 units of packed red blood cells and metabolic acidosis. Primary decompressive laparotomy increased survival in the open surgery group, but not in the endovascular surgery group.
Oliveira, Matias Marchesan de. "ESTUDO DA INCLUSÃO DE COMPARTIMENTOS EM BIODIGESTORES MODELO CANADENSE." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/7957.
The piggery for many years was characterized as a waste-generating activity of high polluter, but in recent decades many studies are responsible for changing this concept. The use of biodigester is well disseminated to lessen the impacts generated by this activity, gaining encouragement deployment in recent years, by encouraging the use of renewable energy. The biodigester is responsible for the production of biogas used as alternative energy on farms that have the digesters system. We observed few studies that investigate the geometry of the digesters and its effects on anaerobic digestion process. This work aimed to study the partitioning of the Canadian model digester anaerobic digestion of swine waste applied to evaluating the degradation (removal) of the physic-chemical parameters (temperature, pH, COD, BOD5, total nitrogen, total phosphorus, total solids, total fixed solids and total volatile solids), and determining a kinetic model describing the biogas produced in each of the compartments of the digesters. For the study were built three reactors in bench scale: the first with a partitioning which caused variation of the horizontal flow, the second with partitioning which flux change generated in the vertical and third, without fragmentation, to be used as a reactor testimony. The analyzes of the physicchemical parameters were made according to Standard Methods for the Examination of Water and Wastewater, since the determination of the kinetic model was done considering the existence of a plug flow (tubular reactor) to each of the reactors constructed and to qualification of biogas was use a gas chromatograph. On the analysis of physic-chemical was second reactor (flow variation vertically) that showed that showed a significant difference in the efficiency of COD removal and pH values, and this reactor also showed better removal of solids and BOD5. Already temperature, showed similar behavior in the three reactors, characterizing the anaerobic digestion occurred primarily in the mesophilic range. Considering the BOD5 as a substrate was obtained as rate constant 0.021 d-1, 0.025 d-1 and 0.024 d-1, respectively for the first, second and third reactor. However, considering the COD as a substrate was obtained 0.032 d-1, and 0.034 d-1, 0.027 d-1 for each of the reactors. Kinetic models had a higher correlation with the experimental data when considering the COD as substrate, and was the second reactor with the highest correlation (R2 = 0.599). In the evaluation of biogas the three reactors not showed difference between them.
A atividade suinícola por muitos anos foi caracterizada como uma atividade geradora de resíduos de alto índice poluidor, porém nas últimas décadas muitos são os estudos responsáveis por mudar esse conceito. O uso de biodigestor está bem disseminado para diminuir os impactos gerados por essa atividade, ganhando estímulo de implantação nos últimos anos, pelo incentivo ao uso de energia renovável. O biodigestor é responsável pela produção do biogás, usado como energia alternativa em propriedades rurais que possuem o sistema de biodigestores. Observam-se poucos trabalhos que pesquisam a geometria dos biodigestores e seus efeitos no processo de digestão anaeróbia. Esse trabalho objetivou o estudo da compartimentação do biodigestor modelo canadense no processo de digestão anaeróbia aplicada a resíduos da suinocultura, avaliando a degradação (remoção) dos parâmetros físico-químicos (temperatura, pH, DQO, DBO5, Nitrogênio total, Fósforo total, sólidos totais, sólidos fixos totais e sólidos voláteis totais), determinando um modelo cinético e qualificando o biogás produzido em cada um dos compartimentos dos biodigestores. Para o estudo foram construídos três reatores em escala de bancada: o primeiro com uma compartimentação que provocava variação de fluxo na horizontal, o segundo com uma compartimentação, a qual gerava variação de fluxo na vertical e o terceiro, sem compartimentação, para ser utilizado como um reator testemunho. As análises dos parâmetros físicoquímicos foram realizadas de acordo com o Standard Methods for Examination of Water and Wastewater, já a determinação do modelo cinético foi realizada considerando a existência de um fluxo pistão (reator tubular) para cada um dos reatores construídos e para a qualificação do biogás utilizou-se um cromatógrafo a gás. Quanto à avaliação dos parâmetros físico químicos, foi o segundo reator (variação de fluxo na vertical) que apresentou diferença significativa na eficiência de remoção de DQO e nos valores de pH, sendo que esse reator também apresentou melhor remoção de DBO5 e sólidos. A temperatura apresentou comportamento semelhante nos três reatores, caracterizando que a digestão anaeróbia ocorreu prioritariamente na faixa mesofílica. Considerando a DBO5 como substrato obteve-se como constante de velocidade 0,021 d-1; 0,025 d-1 e 0,024 d-1, respectivamente para o primeiro, segundo e terceiro reator. Todavia, considerando a DQO como substrato obteve-se 0,032 d-1; 0,034 d-1 e 0,027 d-1 para cada um dos reatores. Os modelos cinéticos apresentaram uma maior correlação com os dados experimentais quando considerada a DQO como substrato, sendo que foi o segundo reator que apresentou maior correlação (R2 = 0,599). Na avaliação do biogás os três reatores não apresentaram diferença entre si.
Vidal, Alexandre Campane 1969. "Caracterização hidrogeoquimica dos compartimentos estruturais da Bacia de Taubate." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287292.
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Geociencias
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Resumo: O sistema aqüífero Taubaté corresponde a uma das principais fontes de exploração de água do Estado de São Paulo. É representado por sedimentos terciários da Bacia de Taubaté, de origem lacustre e fluvial. Este trabalho contou com a revisão dos dados disponíveis na bibliografia e nos órgãos destinados ao abastecimento público. Um banco de dados atual foi realizado através da coleta e análise físico-químico das águas de poços. Para a determinação e caracterização dos tipos lúdroquímicos foi utilizada a estatística convencional e muhivariada de análise de agrupamento. A configuração da distribuição dos tipos foi realizado através de métodos geoestatísticos. Ao todo foram definidos quatro tipos lúdroquimicos que possuem uma relação direta com a litologia da bacia. As amostras do tipo I foram retiradas dos arenitos dos sedimentos fluviais; as amostras do tipo 11, inseridas nos sedimentos fluviais, mas com marcada influência de minerais carbonáticos; as do tipo 111, com influência direta de sedimentos lacustres e. por fim , as do tipo IV, presentes exclusivamente nos sedimentos lacustres. Os diferentes pacotes litológicos originaram águas distintas. As águas correspondentes a sedimentação fluvial, de baixa salinidade e pH, apresentam suas composições químicas controladas principalmente petas reações de substituição e dissolução de silicatos. As. águas referentes aos sedimentos 1acustres. caracterizadas pela alta salinidade e concentração dos íons sódio e bicarbonato, são. controladas peJas reações de dissolução de carbonatos e de troca iônica das argilas
Abstract: The aquifer system of Taubaté stands for 000 of the main supplies of groundwater in São Paulo State. It is represented by terciary sediments of Taubaté Bassin, of lacustrine and fluvialorigin. This work had a initial stage of collecting data disposable in the bibliography and in the department destined to the public supply. To determine and to characterize the hydrochemical types was utüized the conventional and multivariate statistical. The configuration of distribution of types was done through geoestatistical method. Altogether were defined four hydrochemical types, which have a direct relation with the litology of bassin. The samples of type I are inserted in sandstones of fluvial sediments; the samples of type 14 inserted in the fluvial sediments too, but with important influence of carbonates minerais; the water of type 111 has a direct influence of lacustrine sediments; and, at last, the type IV are inserted only in lacustrine sediments. The different IitolOgic groups originate distint water, the water corresponds the fluvial sediments, low salinity and pH, show its chemical composition controlled mainly by substitutions and dissolution reactions of silicates. As the water corresponds at the lacustrine sediments, was characterized by high salinity and concentratian af sodium and bicarbonate ions, it was controlled by reactions of dissolution of carbonate and ion exchange of clays
Mestrado
Geoengenharia de Reservatorios
Mestre em Geociências
CHATEL, JEAN-MARC, and Philippe Ascher. "Un compartiment d'acetylcholinesterase inactive dans les tissus de poulet." Paris 6, 1993. http://www.theses.fr/1993PA066054.
KURAMOTO, GRACIELA B. "Estudo compartimental e dosimétrico do anti-CD20 marcado com 188Re." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26599.
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A radioimunoterapia (RIT) faz uso de anticorpos monoclonais conjugados com radionuclídeos emissores α ou β-, ambos para terapia. O tratamento baseia-se na irradiação e destruição do tumor, preservando os órgãos normais quanto ao excesso de radiação. Radionuclídeos emissores β- como 90Y, 131I, 177Lu e 188Re, são úteis para o desenvolvimento de radiofármacos terapêuticos e, quando associados a AcM como o Anti-CD20 são importantes principalmente para o tratamento de Linfomas Não Hodgkins (LNH). 188Re (Eβ- = 2,12 MeV; Eγ= 155 keV; t1/2 = 16,9 h) é um radionuclídeo atrativo para RIT. O Centro de Radiofarmácia do IPEN possui um projeto que visa a produção do radiofármaco 188Re-Anti-CD20. Com isso,este estudo foi proposto para avaliar a eficácia desta técnica de marcação para tratamento em termos compartimentais e dosimétricos. O objetivo deste trabalho consistiu na compararação da marcação do AcM anti-CD20 com 188Re com a marcação do anticorpo com 90Y, 131I, 177Lu e 99mTc (pelas suas características químicas similares) e 211At, 213Bi, 223Ra e 225Ac. Através do estudo de técnicas de marcação relatadas em literatura, foi proposto um modelo compartimental para avaliação de sua farmacocinética e estudos dosimétricos, de alto interesse para a terapia. A revisão de dados publicados na literatura, possibilitou demonstrar diferentes procedimentos de marcação, rendimentos de marcação, tempo de reação, impurezas e estudos de biodistribuição. O resultado do estudo mostra uma cinética favorável para o 188Re, pelas suas características físicas e químicas frente aos demais radionuclídeos avaliados. O estudo compartimental proposto descreve o metabolismo do 188Re-anti-CD20 através de um modelo compartimental mamilar, que pela sua análise farmacocinética, realizada em comparação aos produtos marcados com emissores β-: 131I-antiCD20, 177Lu-anti-CD20, o emissor γ 99mTc-anti-CD20 e o emissor α 211At-Anti-CD20, apresentou uma constante de eliminação de aproximadamente 0,05 horas-1 no sangue do animal. A avaliação dosimétrica do 188Re-Anti-CD20 foi realizada através de duas metodologias: pelo método de Monte Carlo e pelo uso de uma fonte pontual β- através da Fórmula de Loevinger via programa Excel. Através da Fórmula de Loevinger fez-se a validação do método de Monte Carlo para a dosimetria do 188Re-Anti-CD20 e dos demais produtos. As doses e as taxas de doses obtidas pelos dois métodos foram avaliadas em comparação à dosimetria do 90Y-Anti-CD20, 131I-Anti-CD20 e do 177Lu-Anti-CD20, obtidas pela mesma metodologia. O estudo de dose foi realizado utilizando modelos matemáticos considerando um camundongo nude de 25g, simulando diferentes tamanhos de tumor e diferentes formas de distribuição do produto dentro do animal. De acordo com os resultados obtidos, pela energia de emissão β-, 188Re-Anti-CD20 apresenta maior deposição de energia para tumores volumosos em relação aos demais produtos avaliados. Em uma simulação com 100% do produto captado pelo tumor, 89% da dose total manteve-se absorvida pelo tumor, preservando a integridade de ógãos críticos como coração (2%), pulmões (5%), coluna (4%), fígado (0,014%) e rins (0,0007%). Em uma simulação onde há uma biodistribuição do produto no organismo do animal, 38% da dose total é absorvida pelo tumor e >3% é absorvida pela coluna. Nessa situação mais próxima da realidade, a extrapolação dos dados para um humano de 70kg, mostrou que a dose absorvida no tumor corresponde a cerca de 33%; na coluna 7% e o coração receberia uma dose de 35% do total. A análise compartimental e dosimétrica apresentada neste trabalho, realizada através do uso de um modelo animal para o 188Re-Anti-CD20 mostra que o produto desenvolvido e apresentado em literatura é candidato promissor para a RIT.
Tese (Doutorado em Tecnologia Nuclear)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
Kuramoto, Graciela Barrio. "Estudo compartimental e dosimétrico do anti-CD20 marcado com 188Re." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-14032016-095417/.
The radioimmunotherapy (RIT) uses MAbs conjugated to radionuclides α or β- emitters, both for therapy. Your treatment is based on the irradiation and tumor destruction, preserving the normal organs as the excess radiation. Radionuclides β- emitters as 131I, 90Y, 188Re 177Lu and are useful for the development of therapeutic radiopharmaceuticals and, when coupled with MAb and Anti-CD20 it is important mainly for the treatment of non-Hodgkin\'s lymphomas (NHL). 188Re (Eβ- = 2.12 MeV; Eγ = 155 keV; t1/2 = 16.9 h) is an attractive radionuclide for RIT. However, 188Re can be obtained from a radionuclide generator of 188W/188Re, commercially available, making it convenient for use in research and for clinical routine. The CR of IPEN has a project aimed at the production of radiopharmaceutical 188Re-Anti-CD20, where the radionuclide can be obtained from a generator system 188W/188Re. With this proposed a study to assess the efficiency of this labeling technique for treatment in accordance compartmental and dosimetry. The objective of this study was to compare the marking of anti-CD20 MAb with 188Re with the marking of the antibody with 90Y, 131I, 177Lu and 99mTc (for their similar chemical characteristics) and 211At, 213Bi, 223Ra and 225Ac); through the study of labeling techniques reported in literature, the proposal of a compartmental model to evaluate its pharmacokinetic and dosimetric studies, high interest for therapy. The result of the study shows a favorable kinetics for 188Re, by their physical and chemical characteristics compared to the other evaluated radionuclides. The compartment proposed study describes the metabolism of 188Re-anti-CD20 through a compartment mammillary model, which by their pharmacokinetic analysis, performed compared to products emissores β- 131I-labeled antiCD20, 177Lu-anti-CD20, the γ emitter 99mTc-Anti-CD20 and emitter 211At-Anti-CD20 presented a elimination constant of approximately 0.05 hours-1 in the animal\'s blood. The dosimetric evaluation of 188Re-Anti-CD20 was performed using two methodologies: the Monte Carlo method and the use of a point source β- by Formula Loevinger by Excel program. In the Formula Loevinger, there was a validation of the Monte Carlo method for dosimetry of 188Re-Anti-CD20 and other products. The doses and dose rates obtained by the two methods were evaluated in comparison with 90Y-Anti-CD20, 131I-Anti-CD20 and 177Lu-Anti-CD20 dosimetry, obtained by the same methodology. The dose study was conducted using mathematical models considering a nude mouse 25 g, simulating different tumor sizes and different forms of distribution of the product within the animal. According to the results, the energy emission β-, 188Re-Anti-CD20 has a higher energy deposition for large tumors when compared to other products evaluated. In a simulation with 100% of the product uptake by tumor, 89% of the total dose remained absorbed by the tumor, while preserving the integrity of critical ógãos as heart (2%), lung (5%), column (4%), liver (0.014%) and kidneys (0.0007%). In a simulation where there is a biodistribution of the product in the animal organism, 38% of the total dose absorbed by the tumor and >3% is absorbed by the column. In this situation closer to reality, the extrapolation of the data for a 70kg human, showed that the absorbed dose to tumor corresponds to about 33%; In column 7% and the heart would receive a dose of 35% of the total. The compartmental analysis and dosimetric presented in this work, performed through use of an animal model for the 188Re-anti-CD20 shows that the product developed and presented in the literature is promising candidate for RIT.
Penteado, Thales de Arruda. "Análise da concentração de agente extintor em compartimentos de bagagem." Instituto Tecnológico de Aeronáutica, 2004. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=628.
Oliveira, Adriano dos Santos. "Análise compartimental e aspectos dosimétricos aplicados ao colesterol marcado com 3H." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-21122015-151408/.
Cardiovascular diseases (CVDs) are one of the major reasons of death around the world according to the World Health Organization (WHO). It is well known that changes in levels of plasma lipoproteins, which are responsible for the transport of cholesterol into the bloodstream, are associated with cardiovascular diseases. For this reason to know the biokinetic parameters of plasma lipoproteins and quantifies them is important to correct and deep understanding about the diseases associated with these disorders. The main aim of this study is to provide a biokinetic model and estimate the radiometric doses for 3H-Cholesterol, a radioactive tracer widely used in physiological and metabolic studies. The model was based on [Schwartz et al. 2004] about the distribution of cholesterol by the lipoprotein and gastrointestinal model [ICRP 30, 1979]. The doses distribution in compartments of the model and other organs and tissues of a standard adult described in [ICRP 106, 2008] was calculated using MIRD method (Medical Internal Radiation Dose) and compartmental analysis using the computer program Matlab®. The dose coefficients were estimated for a standard phantom man (73 kg) described in [ICRP 60, 1991]. The estimated doses for both model and for other organs were low and did not exceed the highest dose obtained that was in the upper large intestine, as 46.8 μGy these parameters will assist in ethics committees opinions on the use of works that use the 3H-cholesterol which radioactive tracer.
Le, bars Romain. "Morphogenèse de compartiments membranaires : formation de l'autophagosome chez les plantes." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00968437.
Barsotti, Vanessa. "Recherche et caractérisation de microorganismes dans les compartiments géologiques profonds." Phd thesis, Bordeaux 1, 2011. http://tel.archives-ouvertes.fr/tel-00688631.
Fox, Didier. "Étude de la circulation de particules entre deux compartiments fluidisés." Compiègne, 1987. http://www.theses.fr/1987COMPI255.
Pascal, Véronique Martine Marie. "Exploration des compartiments NK et T NKR+ en physiopathologie humaine." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22073.
Calmet, Dominique. "Synthèse radioécologique des différents compartiments de l'environnement marin du Cotentin." Aix-Marseille 2, 1986. http://www.theses.fr/1986AIX22059.
Calmet, Dominique. "Synthèse radioécologique des différents compartiments de l'environnement marin du Cotentin." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37596220p.
Fox, Didier. "Etude de la circulation de particules entre deux compartiments fluidisés." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376051345.
Bergantin, Federico <1984>. "La sostenibilità nel settore ittico: il compartimento marittimo di Chioggia." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/4440.
Halladja, Sabrina. "Phototransformation du fluométuron et du mécoprop dans le compartiment aquatique." Clermont-Ferrand 2, 2008. http://www.theses.fr/2008CLF21827.
Canut, Hervé. "Proteolyse intracellulaire chez les vegetaux superieurs : role du compartiment vacuolaire." Toulouse 3, 1986. http://www.theses.fr/1986TOU30030.
Canut, Hervé. "Protéolyse intracellulaire chez les végétaux supérieurs rôle du compartiment vacuolaire." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37596244p.
Buffon, Eliege Cassiele. "CARACTERIZAÇÃO LIMNOLÓGICA E ESPECTRAL DE DOIS COMPARTIMENTOS AQUÁTICOS DO RESERVATÓRIO ITAIPU." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/9477.
Inspired by the knowledge that limnological variables in damned bodies of water are a reflection of physical characteristics and from usage and occupation of the land surrounding the water system, and so establishing on the spectral response of the water typical features of optically active components. This study has as a goal to comprehend the behavior from limnological variables making use of remote sensing in the aquatic compartments at Passo Cuê and São Francisco Verdadeiro, located both in the Itaipu reservoir. And as specific goals (i) to comparatively analyze the chlorophyll a spatial limnological distribution, electrical conductivity, dissolved oxygen, hydrogenionic potential (pH), suspended solids and water transparency in the observed aquatic compartments; (ii) to verify the influence of optically active components in the spectral response of the water in both aquatic compartments; (iii) to examine whether the spectral response of the bands 3 and 4 of the Operational Land Imager (OLI) sensor from the Landsat 8 satellite and the ratio of bands have 3/4 asustains any relation to the optically active components of the aquatic compartment at Passo Cuê. The limnological variables are spatialized use of the weighted average interpolation, and afterwards categories are sliced, in thematic format. The analysis of the behavior of the limnological variables on the main channel was done through the identification and measurement of the distance between sample points placed at the area of the main channel in the two aquatic compartments. In order to study the spectral data, collected in situ, the techniques of analysis of spectral reflectance, smoothing of the spectral and derived curve were used. The image from the Landsat 8 satellite, dated to August 22nd, 2014, which covers Passo Cuê aquatic compartment is obtained as requested on the USGS site in reflectance with geometric and atmospheric accuracy. The limnological variables present a uniform behavior at Passo Cuê aquatic compartment, fact that does not occur at São Francisco Verdadeiro aquatic compartment. In addition to that, the behavior of limnological variables allows the characterization of aquatic compartment zones. The limnological variables with exception of the dissolved oxygen, have the tendency to present in the lake zone of the aquatic compartments quite similar concentration values, which shows the standardization of the water from the aquatic compartment to the rest of the reservoir. The usage of the derived technique highlights the presence of the chlorophyll pigment a in the fluvial zone of São Francisco Verdadeiro aquatic compartment. At Passo Cuê aquatic compartment, it was noticed, after using the images from Landsat 8 satellite that the uniform behavior and the low concentration of optically active components have a small influence on the spectral response of the water, fact that can be understood by the low values of associations obtained between the limnological and spectral variables gathered in situ in the aquatic compartment.
A partir do conhecimento que as variáveis limnológicas dos corpos d água represados são um reflexo das características físicas e do uso e ocupação da terra do entorno do sistema hídrico, e que imprimem na resposta espectral da água feições típicas da presença dos constituentes opticamente ativos. O estudo possui como objetivo compreender o comportamento das variáveis limnológicas com o uso do sensoriamento remoto nos compartimentos aquáticos Passo Cuê e São Francisco Verdadeiro, localizados no reservatório Itaipu. E como objetivos específicos, (i) analisar comparativamente a distribuição espacial das variáveis limnológicas clorofila a, condutividade elétrica, oxigênio dissolvido, potencial hidrogeniônico (pH), sólidos em suspensão e transparência da água dos compartimentos aquáticos analisados; (ii) verificar a influência dos constituentes opticamente ativos na resposta espectral da água dos dois compartimentos aquáticos; (iii) averiguar se a resposta espectral das bandas 3 e 4 do sensor Operational Land Imager (OLI) do satélite Landsat 8 e a razão das bandas 3/4 possuem relação com a concentração dos constituentes opticamente ativos do compartimento aquático Passo Cuê. As variáveis limnológicas foram espacializadas com o uso do interpolador média ponderada, e o fatiamento das classes, em formato temático. A análise do comportamento das variáveis limnológicas no canal principal se fez por meio da identificação e medição das distâncias dos pontos amostrais localizados na área do canal principal dos dois compartimentos aquáticos. Para os dados espectrais, obtidos in situ, aplicou-se as técnicas de análise dos espectros de reflectância suavização da curva espectral e derivada. A cena do satélite Landsat 8, da data de 22 de agosto de 2014, que abrange o compartimento aquático Passo Cuê foi obtida por demanda no site da USGS em reflectância com correção geométrica e atmosférica. As variáveis limnológicas apresentaram comportamento mais homogêneo no compartimento aquático Passo Cuê, fato que não ocorre no compartimento aquático São Francisco Verdadeiro, além disto, o comportamento das variáveis limnológicas permite caracterizar as zonas dos compartimentos aquáticos. As variáveis limnológicas com exceção do oxigênio dissolvido possuem a tendência em apresentar na zona lacustre dos compartimentos aquáticos valores de concentração próximos, o que demonstra a uniformização da água dos compartimentos aquáticos com a do restante do reservatório. A utilização da técnica da derivada destacou a presença do pigmento de clorofila a na zona fluvial do compartimento aquático São Francisco Verdadeiro. No compartimento aquático Passo Cuê, constatou-se ao utilizar a imagem de satélite Landsat 8, que o comportamento homogêneo e as baixas concentrações dos constituentes opticamente ativos pouco influenciam na resposta espectral da água, e que pode ser constatado pelos baixos valores de associações obtidos entre as variáveis limnológicas e espectrais coletas in situ no compartimento aquático.
Caiado, Nuno. "Simulação numérica do comportamento térmico de compartimentos sujeitos a incêndios localizados." Master's thesis, Instituto Politécnico de Bragança, Escola Superior de Tecnologia e Gestão, 2012. http://hdl.handle.net/10198/8235.
Pernet-Gallay, Karin. "Etude du rôle dans le trafic membranaire de trois protéines qui lient les microtubules et qui sont associées à l'appareil de Golgi." Paris 11, 2001. http://www.theses.fr/2002PA112071.
The Golgi apparatus is a dynamic structure which morphology depends both on the microtubule network and on membrane transport. I have therefore studied the role in membrane traffic of three proteins that are associated to the Golgi apparatus and that interact with microtubules. First I have studied the interaction of rabkinesin-6 with Golgi membranes. I have shown that the carboxy-terminal domain of this motor protein is sufficient to bind membranes in vitro. However, this interaction is salt sensitive and can not account for the targetting of rabkinesin-6 to Golgi membrane in vivo. Then I have analyzed the phenotype of GMAP-210 overexpressing cells. GMAP-210 is a protein that is localized on the cis side of the Golgi apparatus and that interacts with microtubule minus end. I have shown, by electron microscopy, that the transfection of this protein leads to the disassembly of the Golgi apparatus and induces the formation of vesicle clusters that contain both Golgi enzyme and proteins that cycle between the ER and the Golgi apparatus. Moreover, I have shown that in these cells both anterograde and retrograde transport between the ER and the Golgi apparatus are blocked at the level of these vesicle clusters. Finally, I have participated to the characterization of CLIPR-59, a new protein that has two microtubule binding sites and which is localized on the trans side of the Golgi apparatus. In addition, I have shown that the overexpression of this protein induces the accumulation of endosomal membrane in close apposition of the Golgi apparatus. These results suggest that CLIPR-59 is involved in the regulation of membrane transport between the Golgi apparatus and the endosomal system
Goubier, Vincent. "Influence de la fertilisation sur certains compartiments de l'étang de pisciculture." Lyon 1, 1989. http://www.theses.fr/1989LYO10043.
Dal, Gesso Silvia <1992>. "L'orientamento alla sostenibilità nel settore ittico. Il compartimento marittimo di Chioggia." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/11955.
Szczepaniak-Sion, Catherine. "Implications de la dynamique des compartiments lipidiques dans la croissance cellulaire." Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL112N.
Amouch, Ayoub. "Conception d'un habillage phonique amélioré pour le compartiment moteur d'une motoneige." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/11005.
Michalet, Anne. "Le phosphate dans le compartiment sédimentaire fluvial : influence d'une station d'épuration." Lille 1, 1998. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1998/50376-1998-135.pdf.
Thirree, Richard. "Mesure des compartiments corporels par bio-impédance électrique : A propos du contrôle chez quarante sujets témoins." Aix-Marseille 2, 1991. http://www.theses.fr/1991AIX20213.
Zanata, Marcelo [UNESP]. "Morfometria de compartimentos hidrológicos e qualidade hídrica do município de Batatais-SP." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/105124.
Os objetivos deste trabalho foram os de comparar características morfométricas de compartimentos hidrológicos do município de Batatais nos resultados obtidos de variáveis dimensionais e do relevo a partir da vetorização realizada no sistema de informação geográfica (SIG) e no programa de modelagem SWAT (Soil and Water Assessment Tool), monitorar as características físico-químicas das águas superficiais de algumas nascentes, no intuito de verificar a alteração ambiental em relação ao uso/ocupação do solo dessas microbacias, e correlacionar essas alterações ambientais na análise exploratória multivariada. Os resultados mostram que o SWAT utiliza o modelo digital de elevação, fato que o torna mais apropriado para indicar o maior comprimento do fundo do vale, denominado de Longest path, que o maior comprimento em linha reta entre o deflúvio e a maior cota obtida pelo SIG. Assim, o modelo SWAT não pode ser utilizado para a análise morfométrica completa dos compartimentos hidrológicos, pois não obtém dados suficientes para os cálculos de variáveis dimensionais e do relevo. A análise morfométrica dos compartimentos hidrológicos do município de Batatais indica que essas bacias são menos susceptíveis à degradação ambiental por ser mais alongada que circular em relevo suave ondulado. As medidas de temperatura (TºC), pH, condutividade elétrica (CE) e sólidos dissolvidos totais (SDT) foram obtidas a partir das águas das nascentes e analisadas através da estatística multivariada. Os dados de monitoramento do recurso hídrico mostram estreita relação entre as variáveis SDT e CE, com maior evidencia em relação ao ambiente da microbacia B8, nos meses de dezembro de 2009 e abril de 2011, quando registrou-se o uso de herbicida para controle da braquiária ao redor de sua nascente principal. A alta pluviosidade e os resíduos da atividade agrícola...
The objectives of this study were to compare the morphometric characteristics of hydrological compartments of the municipality of Batatais at the results of the dimensional and the relief variables in a geographic information system (GIS) vectorization and in the SWAT (Soil and Water Assessment Tool), to analyze the physical and chemical characteristics of surface waters of some springs, in order to verify the environmental change in the landuse/landcover of these watersheds and to correlate these environmental changes in an exploratory multivariate analysis. The results showed that SWAT uses the digital elevation model to obtain some physical characteristics, which is appropriated to indicate the greater length of the valley, called Longest path, the longest straight between the runoff and the largest altitude obtained by the GIS. Thus, the SWAT model cannot be used for a complete morphometric analysis on hydrological compartments because it does not obtain sufficient information for calculation of the dimensional and relief variables. The morphometric analysis of hydrological compartments of the municipality of Batatais indicates that these basins are less susceptible to environmental degradation by being more elongated than circular. Measures of the temperature (TºC), pH, electrical conductivity (EC) and total dissolved solids (TDS) were obtained from the spring waters and analyzed by multivariate statistics. Monitoring data of water resources showed a close relationship between the EC and TDS variables, mostly related to the environment of the B8 watershed, at December, 2009 and April, 2011, when it was recorded the use of herbicide to control brachiaria around its spring. The high rainfall and waste of agricultural activity (burning, correction and fertilization) caused changes in water resources of the B8 watershed, that is surrounded by sugarcane. Multivariate analysis showed that the ...
Zanata, Marcelo. "Morfometria de compartimentos hidrológicos e qualidade hídrica do município de Batatais-SP /." Jaboticabal, 2013. http://hdl.handle.net/11449/105124.
Banca: Rogério Teixeira de Faria
Banca: Sérgio Campos
Banca: Elen Fittipaldi Brasilio Carrega
Banca: Valdir de Cicco
Resumo: Os objetivos deste trabalho foram os de comparar características morfométricas de compartimentos hidrológicos do município de Batatais nos resultados obtidos de variáveis dimensionais e do relevo a partir da vetorização realizada no sistema de informação geográfica (SIG) e no programa de modelagem SWAT (Soil and Water Assessment Tool), monitorar as características físico-químicas das águas superficiais de algumas nascentes, no intuito de verificar a alteração ambiental em relação ao uso/ocupação do solo dessas microbacias, e correlacionar essas alterações ambientais na análise exploratória multivariada. Os resultados mostram que o SWAT utiliza o modelo digital de elevação, fato que o torna mais apropriado para indicar o maior comprimento do fundo do vale, denominado de Longest path, que o maior comprimento em linha reta entre o deflúvio e a maior cota obtida pelo SIG. Assim, o modelo SWAT não pode ser utilizado para a análise morfométrica completa dos compartimentos hidrológicos, pois não obtém dados suficientes para os cálculos de variáveis dimensionais e do relevo. A análise morfométrica dos compartimentos hidrológicos do município de Batatais indica que essas bacias são menos susceptíveis à degradação ambiental por ser mais alongada que circular em relevo suave ondulado. As medidas de temperatura (TºC), pH, condutividade elétrica (CE) e sólidos dissolvidos totais (SDT) foram obtidas a partir das águas das nascentes e analisadas através da estatística multivariada. Os dados de monitoramento do recurso hídrico mostram estreita relação entre as variáveis SDT e CE, com maior evidencia em relação ao ambiente da microbacia B8, nos meses de dezembro de 2009 e abril de 2011, quando registrou-se o uso de herbicida para controle da braquiária ao redor de sua nascente principal. A alta pluviosidade e os resíduos da atividade agrícola ...
Abstract: The objectives of this study were to compare the morphometric characteristics of hydrological compartments of the municipality of Batatais at the results of the dimensional and the relief variables in a geographic information system (GIS) vectorization and in the SWAT (Soil and Water Assessment Tool), to analyze the physical and chemical characteristics of surface waters of some springs, in order to verify the environmental change in the landuse/landcover of these watersheds and to correlate these environmental changes in an exploratory multivariate analysis. The results showed that SWAT uses the digital elevation model to obtain some physical characteristics, which is appropriated to indicate the greater length of the valley, called Longest path, the longest straight between the runoff and the largest altitude obtained by the GIS. Thus, the SWAT model cannot be used for a complete morphometric analysis on hydrological compartments because it does not obtain sufficient information for calculation of the dimensional and relief variables. The morphometric analysis of hydrological compartments of the municipality of Batatais indicates that these basins are less susceptible to environmental degradation by being more elongated than circular. Measures of the temperature (TºC), pH, electrical conductivity (EC) and total dissolved solids (TDS) were obtained from the spring waters and analyzed by multivariate statistics. Monitoring data of water resources showed a close relationship between the EC and TDS variables, mostly related to the environment of the B8 watershed, at December, 2009 and April, 2011, when it was recorded the use of herbicide to control brachiaria around its spring. The high rainfall and waste of agricultural activity (burning, correction and fertilization) caused changes in water resources of the B8 watershed, that is surrounded by sugarcane. Multivariate analysis showed that the ...
Doutor
Valentim, Filho José Marcos. "Registro de informações de crédito : análise do sistema de compartimento no Brasil." Universidade de Fortaleza, 2013. http://dspace.unifor.br/handle/tede/91625.
Over the past 30 years, the credit bureaus have assumed a central role in the financial infrastructure of economies worldwide. The development follows the growth of information technology and the formation of global financial markets competitive. Few disagree that greater access to information about borrowers will enable lenders to make smarter decisions, increasing access to credit and reducing information asymmetry. The dissertation will seek to discuss the matter in the light of theoretical formulations and empirical evidence from a dogmatic approach empirical qualitative descriptive purposes using as technical procedure especially literature. In the first section will be far-doctrinal delineation of the role of information in the credit market, their benefits, their effects. The second section will be developed for studying the various systems of information sharing, its structures and forms of dissemination and availability of informational data, the scope of these entries, the variation with respect to the information contained. The third and final section seeks to bring the elements that underlie the core question of this work, that is, the idea that the record of information sharing and its consequent influence on the performance and credit quality. In this last chapter will be traced evidence of this assertion, it is intended, moreover, point to a scenario of open access and sharing of information reduces the asymmetry of information and its effects, allowing greater access to credit. Keywords: Registration information. Brazilian sharing system. Utility.
Nos últimos 30 anos, as agências de crédito têm assumido um papel central na infraestrutura financeira das economias em todo o mundo. O desenvolvimento acompanha o crescimento das tecnologias da informação e a formação de mercados financeiros globais competitivos. Poucos discordam que o maior acesso à informações sobre os tomadores de crédito permitirá às empresas concessoras de crédito tomarem decisões mais inteligentes, aumentando o acesso ao crédito e diminuindo a assimetria informacional. A dissertação discutirá o assunto à luz de formulações teóricas e evidências empíricas, a partir de uma abordagem dogmática empírica qualitativa com objetivos descritivos utilizando como procedimento técnico especialmente a pesquisa bibliográfica. Na primeira seção far-se-á um delineamento doutrinário do papel da informação no mercado de crédito, seus benefícios, seus efeitos. Na segunda seção apresentar-se-á o estudo dos diversos sistemas de compartilhamento de informações, suas estruturas e formas de divulgação e disponibilização dos dados informacionais, a abrangência destes cadastros, a variação em relação à informação contida. A terceira e última seção trará os elementos que fundamentam a questão norteadora desse trabalho, isto é, a ideia de que o registro de informações e seu consequente compartilhamento influência no desempenho e na qualidade do crédito. Neste último capítulo será traçada as evidências desta afirmação, pretende-se, outrossim, apontar que num cenário de amplo acesso e compartilhamento de informação diminui-se a assimetria de informação e seus efeitos, possibilitando um maior acesso ao crédito. Palavras-chave: Registro de informações. Sistema de compartilhamento brasileiro. Utilidade.
Papa, Ramon. "Simulação numérica do transporte de fumaça em compartimento de carga de aeronaves." Instituto Tecnológico de Aeronáutica, 2007. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=427.
Mauclaire, Laurie. "Les aquifères alluviaux : interactions entre les compartiments physique, chimique, microbiologique et faunistique." Lyon 1, 1999. http://www.theses.fr/1999LYO10022.
PFITZINGER, HELENE. "Relation codon-anticodon dans les compartiments chloroplastique et cytoplasmique des plantes superieures." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13153.
Maillet, Laurent. "Compartiments nucleaires et effets de position transcriptionnels chez la levure saccharomyces cerevisiae." Lyon, École normale supérieure (sciences), 1998. http://www.theses.fr/1998ENSL0090.
Fleuriot, Patrice. "Théorie non compartimentale en pharmacocinétique : application aux moments statistiques." Paris 5, 1988. http://www.theses.fr/1988PA05P007.
Jouannic, Jean-Marie. "Impact d'une fistule artéro-veineuse périphérique sur le compartiment vasculaire pulmonaire foetal." Paris 12, 2004. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990003948330204611&vid=upec.
Systemic arteriovenous fistula (AVF) may be associated with postnatal pulmonary hypertension. The aim of our study was to create a prenatal model of AVF in the fetal lamb and to study the impact of this lesion on the feta] pulmonary circulation. At day 14 following the creation of an anastomosis between the jugular vein and the carotid artery in the fetal lamb, both pulmonary arterial pressure and resistance were elevated in the fistula group. This was associated with structural pulmonary vascular abnormalities: increase in number of peripheral muscular arteries together with an increase in pulmonary arterial thickness. In vitro organe bath studies on pulmonary arterial rings showed impaired endothelium-dependent relaxation whether endothelium independent relaxation to sodium nitroprusside was greater in the fistula group. Additional in vivo Doppler study of the arterial pulmonary blood flow showed the creation of the fistula was associated with temporary pulmonary arterial blood flow that did flot last more than six days. In addition we found enhanced accumulation of surfactant material in this prenatal model ofpulmonary hypertension
SENNE, STEPHANIE. "Modelisation globale des echanges thermiques dans un compartiment moteur de vehicule automobile." Paris, ENMP, 1998. http://www.theses.fr/1998ENMP0885.
Recouvreur, Philippe. "Etude du comportement thermique d'un compartiment moteur automobile : modélisation et analyse système." Poitiers, 1999. http://www.theses.fr/1999POIT2371.
Khaled, Mahmoud. "Etude expérimentale des phénomènes aérothermiques dans le compartiment moteur d'un véhicule automobile." Nantes, 2011. http://www.theses.fr/2009NANT2143.
The dissertation work concerns an experimental study of the aerothermal phenomena involved in the vehicle engine compartment. It consists of the understanding of heat transfer between the engine, underhood components and heat exchangers, in relation with the airflow in the underhood. These transfer phenomena have an important effect on the thermal behavior of the underhood components. In addition to the radiative transfers that occur between the different heat sources (engine, exhaust manifold and turbocharger) and other components, the thermal environment of the engine compartment also depends heavily on convective phenomena that occur in this area. The engine compartment is supplied with air by various sources: the fan and the air inlet openings. Convective transfers have then different origins and their mechanisms as well as those of radiative transfers are difficult to grasp. In this context, the work has allowed to develop experimental tools for a physical understanding of heat transfer, model predictions of component temperatures and an analysis of the relationship between the flow topology and convective transfers. The experimental tools helped to better analyze and understand the physical phenomena but also to validate the CFD codes (especially the heat fluxes). Different tests were carried out on a Peugeot 207 passenger car in a large-scale wind tunnel for different driving conditions, idle conditions, and thermal soak of the vehicle and on a simplified laboratory experimental model only for vehicle idle condition