Relevant bibliographies by topics / COMET assay

Academic literature on the topic 'COMET assay'

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Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "COMET assay"

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DİNÇER, Yıldız, and Selin KANKAYA. "Comet Assay for Determining of DNA Damage: Review." Turkiye Klinikleri Journal of Medical Sciences 30, no. 4 (2010): 1365–73. http://dx.doi.org/10.5336/medsci.2009-15258.

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Bivehed, Erik, and Björn Hellman. "Flash-comet assay." MethodsX 7 (2020): 101161. http://dx.doi.org/10.1016/j.mex.2020.101161.

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Baert, Philippe, and Patrick Van Oostveldt. "Miniaturizing the comet assay with 3D vertical comets." Cytometry 51A, no. 1 (December 23, 2002): 26–34. http://dx.doi.org/10.1002/cyto.a.10006.

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Afiahayati, Edgar Anarossi, Ryna Dwi Yanuaryska, and Sri Mulyana. "GamaComet: A Deep Learning-Based Tool for the Detection and Classification of DNA Damage from Buccal Mucosa Comet Assay Images." Diagnostics 12, no. 8 (August 18, 2022): 2002. http://dx.doi.org/10.3390/diagnostics12082002.

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Comet assay is a simple and precise method to analyze DNA damage. Nowadays, many research studies have demonstrated the effectiveness of buccal mucosa cells usage in comet assays. However, several software tools do not perform well for detecting and classifying comets from a comet assay image of buccal mucosa cells because the cell has a lot more noise. Therefore, a specific software tool is required for fully automated comet detection and classification from buccal mucosa cell swabs. This research proposes a deep learning-based fully automated framework using Faster R-CNN to detect and classify comets in a comet assay image taken from buccal mucosa swab. To train the Faster R-CNN model, buccal mucosa samples were collected from 24 patients in Indonesia. We acquired 275 comet assay images containing 519 comets. Furthermore, two strategies were used to overcome the lack of dataset problems during the model training, namely transfer learning and data augmentation. We implemented the proposed Faster R-CNN model as a web-based tool, GamaComet, that can be accessed freely for academic purposes. To test the GamaComet, buccal mucosa samples were collected from seven patients in Indonesia. We acquired 43 comet assay images containing 73 comets. GamaComet can give an accuracy of 81.34% for the detection task and an accuracy of 66.67% for the classification task. Furthermore, we also compared the performance of GamaComet with an existing free software tool for comet detection, OpenComet. The experiment results showed that GamaComet performed significantly better than OpenComet that could only give an accuracy of 11.5% for the comet detection task. Downstream analysis can be well conducted based on the detection and classification results from GamaComet. The analysis showed that patients owning comet assay images containing comets with class 3 and class 4 had a smoking habit, meaning they had more cells with a high level of DNA damage. Although GamaComet had a good performance, the performance for the classification task could still be improved. Therefore, it will be one of the future works for the research development of GamaComet.
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McArt, Darragh G., George McKerr, C. Vyvyan Howard, Kurt Saetzler, and Gillian R. Wasson. "Modelling the comet assay." Biochemical Society Transactions 37, no. 4 (July 22, 2009): 914–17. http://dx.doi.org/10.1042/bst0370914.

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The single-cell gel electrophoresis technique or comet assay is widely regarded as a quick and reliable method of analysing DNA damage in individual cells. It has a proven track record from the fields of biomonitoring to nutritional studies. The assay operates by subjecting cells that are fixed in agarose to high salt and detergent lysis, thus removing all the cellular content except the DNA. By relaxing the DNA in an alkaline buffer, strands containing breaks are released from supercoiling. Upon electrophoresis, these strands are pulled out into the agarose, forming a tail which, when stained with a fluorescent dye, can be analysed by fluorescence microscopy. The intensity of this tail reflects the amount of DNA damage sustained. Despite being such an established and widely used assay, there are still many aspects of the comet assay which are not fully understood. The present review looks at how the comet assay is being used, and highlights some of its limitations. The protocol itself varies among laboratories, so results from similar studies may vary. Given such discrepancies, it would be attractive to break the assay into components to generate a mathematical model to investigate specific parameters.
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B�cker, W., W. Rolf, T. Bauch, W. U. M�ller, and C. Streffer. "Automated comet assay analysis." Cytometry 35, no. 2 (February 1, 1999): 134–44. http://dx.doi.org/10.1002/(sici)1097-0320(19990201)35:2<134::aid-cyto5>3.0.co;2-9.

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Kawaguchi, Satomi, Takanori Nakamura, Ayumi Yamamoto, Gisho Honda, and Yu F. Sasaki. "Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?" Journal of Nucleic Acids 2010 (2010): 1–8. http://dx.doi.org/10.4061/2010/541050.

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Although the Comet assay, a procedure for quantitating DNA damage in mammalian cells, is considered sensitive, it has never been ascertained that its sensitivity is higher than the sensitivity of other genotoxicity assays in mammalian cells. To determine whether the power of the Comet assay to detect a low level of genotoxic potential is superior to those of other genotoxicity assays in mammalian cells, we compared the results of Comet assay with those of micronucleus test (MN test). WTK1 human lymphoblastoid cells were exposed to methyl nitrosourea (MNU), ethyl nitrosourea (ENU), methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), bleomycin (BLM), or UVC. In Comet assay, cells were exposed to each mutagen with (Comet assay/araC) and without (Comet assay) DNA repair inhibitors (araC and hydroxyurea). Furthermore, acellular Comet assay (acellular assay) was performed to determine how single-strand breaks (SSBs) as the initial damage contributes to DNA migration and/or to micronucleus formation. The lowest genotoxic dose (LGD), which is defined as the lowest dose at which each mutagen causes a positive response on each genotoxicity assay, was used to compare the power of the Comet assay to detect a low level of genotoxic potential and that of MN test; that is, a low LGD indicates a high power. Results are summarized as follows: (1) for all mutagens studied, LGDs were MN test ≦ Comet assay; (2) except for BLM, LGDs were Comet assay/araC ≦ MN test; (3) except for UVC and MNU, LGDs were acellular assay ≦ Comet assay/araC ≦ MN test ≦ Comet assay. The following is suggested by the present findings: (1) LGD in the Comet assay is higher than that in MN test, which suggests that the power of the MN test to detect a low level of genotoxic potential is superior to that of the Comet assay; (2) for the studied mutagens, all assays were able to detect all mutagens correctly, which suggests that the sensitivity of the Comet assay and that of the MN test were exactly identical; (3) the power of the Comet assay to detect a low level of genotoxic potential can be elevated to a level higher than that of MN test by using DNA resynthesis inhibitors, such as araC and HU.
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Kennedy, E. K., J. P. McNamee, L. Prud'homme Lalonde, T. Jones, and D. Wilkinson. "Acellular comet assay: a tool for assessing variables influencing the alkaline comet assay." Radiation Protection Dosimetry 148, no. 2 (March 11, 2011): 155–61. http://dx.doi.org/10.1093/rpd/ncr027.

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Zee, Yeng Peng, Carmen López-Fernández, F. Arroyo, Stephen D. Johnston, William V. Holt, and Jaime Gosalvez. "Evidence that single-stranded DNA breaks are a normal feature of koala sperm chromatin, while double-stranded DNA breaks are indicative of DNA damage." REPRODUCTION 138, no. 2 (August 2009): 267–78. http://dx.doi.org/10.1530/rep-09-0021.

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In this study, we have used single and double comet assays to differentiate between single- and double-stranded DNA damage in an effort to refine the interpretation of DNA damage in mature koala spermatozoa. We have also investigated the likelihood that single-stranded DNA breakage is part of the natural spermiogenic process in koalas, where its function would be the generation of structural bends in the DNA molecule so that appropriate packaging and compaction can occur. Koala spermatozoa were examined using the sperm chromatin dispersion test (SCDt) and comet assays to investigate non-orthodox double-stranded DNA. Comet assays were conducted under 1) neutral conditions; and 2) neutral followed by alkaline conditions (double comet assay); the latter technique enabled simultaneous visualisation of both single-stranded and double-stranded DNA breaks. Following the SCDt, there was a continuum of nuclear morphotypes, ranging from no apparent DNA fragmentation to those with highly dispersed and degraded chromatin. Dispersion morphotypes were mirrored by a similar diversity of comet morphologies that could be further differentiated using the double comet assay. The majority of koala spermatozoa had nuclei with DNA abasic-like residues that produced single-tailed comets following the double comet assay. The ubiquity of these residues suggests that constitutive alkali-labile sites are part of the structural configuration of the koala sperm nucleus. Spermatozoa with ‘true’ DNA fragmentation exhibited a continuum of comet morphologies, ranging from a more severe form of alkaline-susceptible DNA with a diffuse single tail to nuclei that exhibited both single- and double-stranded breaks with two comet tails.
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Teixeira Neto, Paulo Florentino, Ronald Feitosa Pinheiro, and Romélia Pinheiro Gonçalves. "Comet assay in myelodysplastic syndromes." Revista Brasileira de Hematologia e Hemoterapia 34, no. 4 (2012): 317. http://dx.doi.org/10.5581/1516-8484.20120080.

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Dissertations / Theses on the topic "COMET assay"

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Pigorsch, Steffi Ulrike. "Untersuchungen zur Radiosensitivität mit dem Comet-Assay." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963220853.

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McArt, Darragh Gerrard. "Systematic quantitative analysis of the comet assay." Thesis, University of Ulster, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551559.

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The single cell gel electrophoresis assay (comet assay) has been widely used over the last 30 years. It is a robust method of estimating DNA movement under perturbation. In the assay cells are embedded in agarose on a frosted slide. The amount of broken or fragmented DNA that is removed from the central body, after the cell has been lysed and electrophoresed, is estimated as the total volume of DNA damage in the form of strand breaks caused by the insult. The damage is quantified by fluorescence microscopy with analysis software. It is a simple technique that is efficient and relatively quick. With the comet methodology there is much debate on the underlying mechanisms of cellular damage and repair and over how strongly the comet shape reflects the DNA damage that has occurred. It is often used as a quick-fire detection method to back up other analysis methods with very little thought given to the information it provides. The technique itself is open to experimenter bias at the microscopy level, where researchers have the freedom to select which comets to analyse. Addressing these issues along with those of standardising the technique and developing novel methods of comet analysis may enhance the information it provides. Using statistical and computational methods, it is proposed that a simulation of the comet would provide important information about DNA damage at a cellular level while offering impartial judgement and reproducibility. Information is available on some aspects of comet structure in published literature and with new techniques both computationally and experimentally it has become possible to examine intrinsic information on comet structure. Information was also established via novel and existing laboratory techniques and also through microscopy techniques to examine architecture. A computational modelling and simulation approach can then be used to ask important biological questions on aspects of DNA damage and repair at a cellular level.
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Schmid, Oliver. "Untersuchungen zur Genotoxizität von Formaldehyd in vitro und in vivo." [S.l. : s.n.], 2009. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-66943.

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Menke, Merten. "Molekulare Grundlagen und Anwendungsmöglichkeiten des Comet Assay in Pflanzen." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963172751.

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Hoffmann, Heike. "Der Comet Assay als Test im Biomonitoring - Untersuchungen zum Nachweis genotoxischer Effekte des Rauchens." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56705.

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Paiva, Jean Carlos Gomes. "Biomonitoramento GenÃtico de Agricultores expostos a Pesticidas nos MunicÃpios de Tianguà e Ubajabra CearÃ." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7093.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
Nos Ãltimos anos, o uso de pesticidas na agricultura tem aumentado e associaÃÃes entre a exposiÃÃo a produtos quÃmicos agrÃcolas e danos ao DNA e cÃncer tem sido relatados. O Brasil à um dos lÃderes mundiais na utilizaÃÃo de pesticidas, no entanto, estudos que avaliem o impacto da exposiÃÃo ocupacional a pesticidas sobre a incidÃncia e mortalidade por cÃncer ainda sÃo escassos na populaÃÃo brasileira. O teste do cometa alcalino e a anÃlise de aberraÃÃes cromossÃmicas (AC) foram utilizados para avaliar danos primÃrios ao DNA em linfÃcitos do sangue perifÃrico de trabalhadores expostos a uma mistura complexa de pesticidas em duas pequenas comunidades rurais nos municÃpios de Tianguà e Ubajara, localizados no oeste do Estado do Cearà (Nordeste do Brasil). Estes MunicÃpios estÃo entre as maiores Ãreas agrÃcolas do Estado. O teste do cometa mostrou que o Ãndice e freqÃÃncia de danos observados nos grupos expostos foram significativamente maiores em relaÃÃo aos grupos controle (P <0,05). Por outro lado, nÃo foram detectadas diferenÃas significativas em relaÃÃo a AC estruturais e numÃricas nas comunidades avaliadas. AlÃm disso, os nÃveis observados de quebras da fita de DNA e freqÃÃncias de AC, estratificadas por tempo de exposiÃÃo, nÃo foram estatisticamente diferentes nos agricultores de ambas comunidades rurais. Os resultados sugerem que os danos causados por pesticidas na Ãrea de estudo nÃo foram significativos o suficiente para induzir mutaÃÃes permanentes ou interferir na formaÃÃo do aparelho mitÃtico. Danos mÃnimos causados pelos pesticidas podem ter sido submetidos a reparo celular, explicando a ausÃncia de AC estruturais e numÃricas. As anÃlises da Ãgua do reservatÃrio que serve de fonte para irrigaÃÃo das plantaÃÃes e abastece os municÃpios da regiÃo nÃo detectou contaminaÃÃo por resÃduos de pesticidas.
In recent years, the use of pesticides in agriculture has been steadily increasing, and associations between exposure to agricultural chemicals and DNA damage and cancer have been reported. Brazil is one of the world leaders in pesticide use; however, studies that evaluate the impact of pesticide exposure on cancer incidence and mortality are very scarce in the Brazilian population. The alkaline comet assay and the chromosome aberration (CA) test were used to evaluate primary DNA damage in the peripheral blood lymphocytes of workers exposed to a complex mixture of pesticides in two small rural communities in the municipalities of Tianguà and Ubajara, located in the western part of Cearà State (Northeast Brazil), which are among the largest agricultural areas of the state. The comet assay showed that the damage index and damage frequency observed in the exposed groups were significantly higher in relation to the controls (P < 0.05). On the other hand, no differences were detected regarding structural and numerical CAs in the communities evaluated. Additionally, the observed levels of DNA strand breaks and frequencies of CAs, stratified for exposure time, were not statistically different for individuals of either rural community. Our results suggest that the damages caused by pesticides in our study area were not great enough to induce permanent mutations or to interfere with mitotic apparatus formation; minimal pesticide damages could have undergone cellular repair, explaining the absence of structural and numerical CAs. Analyses of water from the reservoir that serves as a source for irrigation of crops and supplies the cities of the region did not detect contamination by pesticides.
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DUARTE, RENATO C. "Teste do cometa como ferramenta de controle da cadeia do frio." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9435.

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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Leyk, Williams Malgorzata. "Summarizing FLARE assay images in colon carcinogenesis." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3132.

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Intestinal tract cancer is one of the more common cancers in the United States. While in some individuals a genetic component causes the cancer, the rate of cancer in the remainder of the population is believed to be affected by diet. Since cancer usually develops slowly, the amount of oxidative damage to DNA can be used as a cancer biomarker. This dissertation examines effective ways of analyzing FLARE assay data, which quantifies oxidative damage. The statistical methods will be implemented on data from a FLARE assay experiment, which examines cells from the duodenum and the colon to see if there is a difference in the risk of cancer due to corn or fish oil diets. Treatments of the oxidizing agent dextran sodium sulfate (DSS), DSS with a recovery period, as well as a control will also be used. Previous methods presented in the literature examined the FLARE data by summarizing the DNA damage of each cell with a single number, such as the relative tail moment (RTM). Variable skewness is proposed as an alternative measure, and shown to be as effective as the RTM in detecting diet and treatment differences in the standard analysis. The RTM and skewness data is then analyzed using a hierarchical model, with both the skewness and RTM showing diet/treatment differences. Simulated data for this model is also considered, and shows that a Bayes Factor (BF) for higher dimensional models does not follow guidelines presented by Kass and Raftery (1995). It is hypothesized that more information is obtained by describing the DNA damage functions, instead of summarizing them with a single number. From each function, seven points are picked. First, they are modeled independently, and only diet effects are found. However, when the correlation between points at the cell and rat level is modeled, much stronger diet and treatment differences are shown both in the colon and the duodenum than for any of the previous methods. These results are also easier to interpret and represent graphically, showing that the latter is an effective method of analyzing the FLARE data.
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Garcia, Juliana Maia Rabêlo Nucci. "Adaptação de Ensaio Cometa às células meristemáticas provenientes de raízes de propágulos de Rhizophora mangle para avaliar a genotoxicidade no ambiente marinho." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/21/21134/tde-24022017-142221/.

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O presente estudo teve como objetivo o estabelecimento de um método citogenotoxico, o ensaio cometa, adaptado às células meristemáticas provenientes de raízes de propágulos de mangue da espécie Rhizophora mangle para utilização em estudos sobre genotoxicidade em ambientes marinhos. Foram testados dois tipos de germinação de raízes, quatro diferentes soluções de extração de núcleos, duas soluções de lise e o não uso da lise, dois períodos de exposição à lise, dois períodos de relaxamento, dois períodos de eletroforese e a interação de duas condições de lise com dois diferentes tempos de relaxamento. A validação de método foi realizada através da exposição de núcleos a quatro diferentes concentrações de peróxido de hidrogênio. Os resultados mostraram que é possível a obtenção de cometas com núcleos extraídos de propágulos de Rhizophora mangle e que a validação de método apresenta uma relação concentração dependente entre o índice de dano de núcleos e a concentração do agente genotoxico testado. Os melhores parâmetros utilizados para obtenção de cometas através do método por nós adaptado são: PBS ou solução salina 12‰ como solução de extração, exposição à lise alcalina iônica por 60 minutos, 5 minutos de relaxamento e eletroforese em tampão pH>13, 0,8V/cm, 230mA por 20 minutos a 4ºC.
This study aimed to establish a citogenotoxic method, the comet assay, adapted to the meristematic cells from propagule roots of red mangrove, Rhizophora mangle, for use in studies of genotoxicity in marine environments. Experiments were carried out to test two ways of root germination, four different nuclei extraction solutions, two lysis solutions and without lysis, two periods of exposure to lysis, two periods of unwinding, two periods of electrophoresis and the interaction of two lysis conditions with two different times of unwinding. Experiments on validation of the method were performed by exposing the nuclei to four different concentrations of hydrogen peroxide. The results showed that it is possible to obtain comets with nuclei extracted from the root of propagules of Rhizophora mangle and the validation data showed a dose-dependent relationship between the damage index and the concentration of the genotoxic agent tested. The best parameters to obtain comets using the method adapted by us are: PBS or saline 12‰ as extraction solution, exposure to alkaline lysis for 60 minutes, 5 minutes of unwinding and electrophoresis in buffer pH> 13, 0,8V/cm, 230mA for 20 min at 4ºC.
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Paiva, Jean Carlos Gomes. "Biomonitoramento Genético de Agricultores expostos a Pesticidas nos Municípios de Tianguá e Ubajabra Ceará." reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/16960.

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PAIVA, Jean Carlos Gomes. Biomonitoring genetic of farmers exposed to pesticides in the municipalities of Tiangua and Ubajara (Ceará, Brazil). 2011. 111 f. : Tese (doutorado) - Universidade Federal do Ceará, Programa de Pós-Graduação em Biotecnologia, Renorbio - Rede Nordeste de Biotecnologia. 2011.
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Books on the topic "COMET assay"

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Dhawan, Alok, and Diana Anderson, eds. The Comet Assay in Toxicology. Cambridge: Royal Society of Chemistry, 2009. http://dx.doi.org/10.1039/9781847559746.

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Dhawan, Alok. The comet assay in toxicology. Cambridge: RSC Pub., 2009.

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Burns, Anthony J. Gut lumen factors, including probiotics and prebiotics, influencing faecal water genotoxicity on HT29 cell line using the comet assay. [S.l: The author], 2002.

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Melia, Noelle. Analysis by use of the comet assay, of DNA content and integrity in cells extracted from bladder washing specimens fromtumor and control patients. [S.l: The Author], 1994.

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Cavaciocchi, Simonetta, ed. Schiavitù e servaggio nell’economia europea SECC. XI-XVIII / Serfdom and Slavery in the European Economy 11th-18 th Centuries. Florence: Firenze University Press, 2014. http://dx.doi.org/10.36253/978-88-6655-562-9.

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Il volume esamina i rapporti di lavoro non contrattuali (schiavitù e servaggio) che a lungo contraddistinsero l’economia europea, sia pure con andamenti assai diversi nelle differenti aree. I saggi in esso contenuti esaminano la evoluzione del servaggio (visto come il lato economico del regime signorile) e delle diverse forme di sottomissione personale, fino alla vera e propria tratta degli schiavi, di cui i mercanti europei furono protagonisti, mettendo in luce una situazione assai più complessa e articolata di quanto gli schemi interpretativi tradizionali lasciassero intuire.
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Torlone, Francesca, ed. Il diritto al risarcimento educativo dei detenuti. Florence: Firenze University Press, 2016. http://dx.doi.org/10.36253/978-88-6655-926-9.

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L’esecuzione della pena in ottica (ri)educativa è tema assai dibattuto attraverso approcci anche multidisciplinari. In questo volume esso è affrontato in chiave risarcitoria, ovvero attraverso il riconoscimento della necessità di predisporre dispositivi educativi di contrasto alle ‘azioni educative avverse’, cui può essere esposta la popolazione detenuta all’interno di contesti penitenziari, ed al fenomeno della recidiva. Oltre agli elementi del programma trattamentale (strutturato, intenzionale, normato e proceduralizzato), ogni momento di espiazione della pena – anche quelle taken for granted – ha in sé una valenza educativa e si presenta come opportunità di crescita e miglioramento per ciascun detenuto. Il volume raccoglie una serie di contributi da professionisti del sistema penale a testimonianza della varietà di esperienze, con senso educativo, che supportano i processi di cambiamento dei detenuti.
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Ferro, Maria Chiara, Laura Salmon, and Giorgio Ziffer, eds. Contributi italiani al XVI Congresso Internazionale degli Slavisti. Florence: Firenze University Press, 2018. http://dx.doi.org/10.36253/978-88-6453-723-8.

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I ventitré saggi contenuti nel volume rappresentano i contributi della delegazione italiana al XVI Congresso internazionale degli Slavisti, che si svolge a Belgrado nell’agosto del 2018. Scritti in italiano, inglese, russo e serbo, i saggi sono suddivisi in tre sezioni: linguistica, filologia e letterature slave. Come assai ampio è il ventaglio dei temi toccati, così è quantomai largo il loro arco cronologico, che dall’epoca pre- e protostorica arriva fino ai nostri giorni. Gli argomenti trattati si estendono in effetti dal protoslavo alle tradizioni scrittoria, linguistica e letteraria della civiltà slava ecclesiastica, dai rapporti linguistici e culturali fra Italia e Russia a un particolare dizionario illirico del Settecento. Nel settore della linguistica sincronica troviamo saggi in cui si approfondiscono questioni di dialettologia e sociolinguistica nell’area di confine tra Ucraina e Bielorussia, e poi i modi di esprimere il concetto di completezza in russo, alcuni costrutti concessivi del russo studiati con i metodi della ‘grammatica costruzionista’, un particolare aspetto dei sistemi verbali russo e bulgaro, e i diversi suffissi impiegati nella formazione delle coppie aspettuali nel dialetto resiano. In ambito letterario si spazia invece da Gumilev e Chlebnikov a saggi che parlano di letteratura ed ecologia, dagli scrittori armeni che scrivono in russo al poema neolatino Il canto del bisonte e ai riflessi umanistici e rinascimentali nella letteratura ucraina moderna, da una studiosa italiana di letteratura serba della prima metà del Novecento all’immagine della ‘donna forte’ nella letteratura serba dello stesso periodo. Con la loro varietà questi saggi offrono quindi nel loro insieme un’idea assai concreta di diversi degli attuali filoni di ricerca della slavistica italiana.
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Rossi, Maddalena, and Claudio Saragosa, eds. I territori della contemporaneità. Florence: Firenze University Press, 2019. http://dx.doi.org/10.36253/978-88-6453-805-1.

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Il testo raccoglie la rielaborazione di alcune delle tesi di laurea più significative prodotte, dal 2011 al 2015, nei corsi di laurea triennale in Pianificazione della città, del territorio e del paesaggio e di laurea magistrale in Pianificazione e progettazione della città e del territorio dell’Università di Firenze, con sede a Empoli. Le tesi trattano un panorama attuale e variegato di problematiche interne alla disciplina urbanistica, utilizzando metodologie, chiavi di lettura e prospettive di analisi assai diverse. Il territorio che emerge come protagonista delle narrazioni dei giovani autori è un oggetto complesso e pluristratificato, fatto di cose e relazioni, adagiato sui tempi lunghi della storia, teso sul presente e proiettato nel futuro, che continua a sollecitare loro domande, dubbi, curiosità e anche alcune fruttuose risposte. In sintesi, più che campi di discussione di un sapere acquisito e valido una volta per tutte, i lavori qui presentati rappresentano campi di riflessione e di sperimentazione, occasioni di costruzione incrementale di soluzioni creative da parte degli autori.
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Anderson, Diana, and Alok Dhawan. Comet Assay in Toxicology. Royal Society of Chemistry, The, 2016.

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Plewa, Michael, Declan McKenna, Giada Frenzilli, Tomas Gichner, and Maria Dusinska. Comet Assay in Toxicology. Royal Society of Chemistry, The, 2016.

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Book chapters on the topic "COMET assay"

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Knowlton, Christin A., Michelle Kolton Mackay, Tod W. Speer, Robyn B. Vera, Douglas W. Arthur, David E. Wazer, Rachelle Lanciano, et al. "Comet Assay." In Encyclopedia of Radiation Oncology, 132. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_609.

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Schmezer, Peter. "Comet Assay." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_1275-2.

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Kalmar, Jayne M., Brigid M. Lynch, Christine M. Friedenreich, Lee W. Jones, A. N. Bosch, Alessandro Blandino, Elisabetta Toso, et al. "Comet Assay." In Encyclopedia of Exercise Medicine in Health and Disease, 199. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2242.

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Schmezer, Peter. "Comet Assay." In Encyclopedia of Cancer, 1189–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_1275.

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Cortés-Gutiérrez, Elva I., Martha I. Dávila-Rodríguez, and Carmen López-Fernández. "The Comet Assay." In A Clinician's Guide to Sperm DNA and Chromatin Damage, 119–35. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71815-6_7.

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Reisinger, Kerstin, and Stefan Pfuhler. "3D Skin Comet Assay." In Alternatives for Dermal Toxicity Testing, 527–39. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50353-0_38.

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Santoro, Raffaela, Maria Ferraiuolo, Gian Paolo Morgano, Paola Muti, and Sabrina Strano. "Comet Assay in Cancer Chemoprevention." In Methods in Molecular Biology, 99–105. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3191-0_9.

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Devaux, Alain, and Sylvie Bony. "Genotoxicity of Contaminants: Comet Assay." In Encyclopedia of Aquatic Ecotoxicology, 559–68. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5704-2_53.

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Hovhannisyan, Galina, Tigran Harutyunyan, and Rouben Aroutiounian. "FISH—and Single-Cell Gel Electrophoresis Assay (Comet Assay)." In Cytogenetics and Molecular Cytogenetics, 211–23. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003223658-20.

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Anderson, Diana, Alok Dhawan, and Julian Laubenthal. "The Comet Assay in Human Biomonitoring." In Methods in Molecular Biology, 259–74. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9646-9_13.

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Conference papers on the topic "COMET assay"

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Kiziltan, Erhan, and Erkan Yurtcu. "Semi-automatic scoring tool for comet assay." In 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2015. http://dx.doi.org/10.1109/bibe.2015.7367718.

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Serrano Delgado, Daya, Sergio D. Pulido Castro, Juan M. López López, Álvaro J. Bocanegra Pérez, Alejandro O. Ondo Méndez, and Francisco J. Londoño Hoyos. "Flexible automatic algorithm for comet assay analysis." In 14th International Symposium on Medical Information Processing and Analysis, edited by Eduardo Romero, Natasha Lepore, and Jorge Brieva. SPIE, 2018. http://dx.doi.org/10.1117/12.2511199.

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Sehirli, Eftal, M. Kamil Turan, and Emrullah Demiral. "A randomized automated thresholding method to identify comet objects on comet assay images." In the 3rd International Conference. New York, New York, USA: ACM Press, 2017. http://dx.doi.org/10.1145/3162957.3163044.

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Koenig, Karsten, Hartmut Oehring, Karl-Juergen Halbhuber, Ursula Fiedler, Eckhard Bauer, and Karl-Otto Greulich. "Comet assay, cloning assay, and light and electron microscopy on one preselected cell." In BiOS Europe '97, edited by Francesco Baldini, Nathan I. Croitoru, Mark R. Dickinson, Martin Frenz, Mitsunobu Miyagi, Riccardo Pratesi, and Stefan Seeger. SPIE, 1998. http://dx.doi.org/10.1117/12.301123.

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Sreelatha, G., P. Rashmi, P. S. Sathidevi, M. Aparna, P. Chand, and R. P. Rajkumar. "Automatic detection of comets in Silver stained comet assay images for DNA damage analysis." In 2014 IEEE International Conference on Signal Processing, Communications and Computing (ICSPCC). IEEE, 2014. http://dx.doi.org/10.1109/icspcc.2014.6986250.

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Bernardini, Michele, Alessandro Ferri, Lucia Migliorelli, Sara Moccia, Luca Romeo, Sonia Silvestri, Luca Tiano, and Adriano Mancini. "Augmented Microscopy for DNA Damage Quantification: A Machine Learning Tool for Environmental, Medical and Health Sciences." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97902.

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Abstract The Comet Assay is a well-known procedure employed to investigate the DNA damage and can be applied to several research areas such as environmental, medical and health sciences. User dependency and computation time effort represent some of the major drawbacks of the Comet Assay. Starting from this motivation, we applied a Machine Learning (ML) tool for discriminating DNA damage using a standard hand-crafted feature set. The experimental results demonstrate how the ML tool is able to objectively replicate human experts scoring (accuracy detection up to 92%) by solving the related binary task (i.e., controls vs damaged comets).
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Koenig, Karsten, Tatiana B. Krasieva, Eckhard Bauer, Ulrich Fiedler, Michael W. Berns, Bruce J. Tromberg, and Karl-Otto Greulich. "UVA-induced oxidative stress in single cells probed by autofluorescence modifications, cloning assay, and comet assay." In Barcelona - DL tentative, edited by Hans-Jochen Foth, Renato Marchesini, Halina Podbielska, Michel Robert-Nicoud, and Herbert Schneckenburger. SPIE, 1996. http://dx.doi.org/10.1117/12.230020.

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Ghosh, Swarupa, Ilika Ghosh, and Anita Mukherjee. "Comet assay based detection of SPION induced DNA damage in human lymphocytes." In 2016 International Conference on Systems in Medicine and Biology (ICSMB). IEEE, 2016. http://dx.doi.org/10.1109/icsmb.2016.7915095.

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Zeng, Guoming, Maolan Zhang, and Pu Wang. "Genotoxicity effects of Phanerochaete chrysosporium against harmful algal bloom species by comet assay." In 2017 3rd International Forum on Energy, Environment Science and Materials (IFEESM 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/ifeesm-17.2018.339.

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Sizochenko, Natalia, Bakhtiyor Rasulev, and Jerzy Leszczynski. "Nanoparticles mutagenicity: search for matches and potential limitations of Comet assay and Ames test." In MOL2NET 2016, International Conference on Multidisciplinary Sciences, 2nd edition. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/mol2net-02-03898.

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