Academic literature on the topic 'Colorectal cancer, tomato, tomato extract'
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Journal articles on the topic "Colorectal cancer, tomato, tomato extract"
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CENARIU, Diana, Eva FISCHER-FODOR, Piroska VIRAG, Corina TATOMIR, Mihai CENARIU, Emoke PALL, Adela PINTEA, Andrei MOCAN, Ioan SIMON, and Gianina CRISAN. "In vitro Antitumour Activity of Tomato-Extracted Carotenoids on Human Colorectal Carcinoma." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 43, no. 2 (December 10, 2015): 293–301. http://dx.doi.org/10.15835/nbha4329982.
Full textAbstract:
The aim of this research was to establish whether all-trans lycopene extracted from fresh and frozen tomatoes is able to inhibit the in vitro proliferation of colon cancer cells, to trigger apoptosis by reactive oxygen species modulation and to reveal its influence on NF-kβ signalling, through the p65 transcription factor and expression of two TNF receptors: GITR and CD27. The carotenoid extracts containing all-trans lycopene were obtained from fresh (E1) and frozen/thawed (E2) tomatoes (Lycopersicon esculentum Mill.), hybrid ‘Menhir’ F1. DLD-1 and HT-29 human colon adenocarcinoma cell lines were co-cultivated with the two extracts and cytotoxicity, apoptosis, antioxidant activity, reactive oxygen species as well as modulation of NF-kβ signalling pathway were assessed. Tomato extracts E1 and E2 were able to inhibit colon cancer cell growth in vitro. E2 contained a higher proportion of all-trans lycopene and displayed superior cytotoxicity and a better apoptosis inducing capacity. The two extracts proved antioxidant activity against DPPH radicals and were able to scavenge the reactive oxygen species in the treated tumour cells. This study also showed that lycopene acts mainly through p65 protein and moderately by TNF receptors GITR and CD27 to deactivate the NF-kβ signalling pathway involved in cancer cell proliferation.
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Di Lecce, Roberta, Natacha Mérindol, Mayra Galarza Pérez, Vahid Karimzadegan, Lionel Berthoux, Angela Boari, Christian Zidorn, et al. "Biochemical Analyses of Bioactive Extracts from Plants Native to Lampedusa, Sicily Minor Island." Plants 11, no. 24 (December 9, 2022): 3447. http://dx.doi.org/10.3390/plants11243447.
Full textAbstract:
Major threats to the human lifespan include cancer, infectious diseases, diabetes, mental degenerative conditions and also reduced agricultural productivity due to climate changes, together with new and more devastating plant diseases. From all of this, the need arises to find new biopesticides and new medicines. Plants and microorganisms are the most important sources for isolating new metabolites. Lampedusa Island host a rich contingent of endemic species and subspecies. Seven plant species spontaneously growing in Lampedusa, i.e., Atriplex halimus L. (Ap), Daucus lopadusanus Tineo (Dl), Echinops spinosus Fiori (Es) Glaucium flavum Crantz (Gf) Hypericum aegypticum L: (Ha), Periploca angustifolia Labill (Pa), and Prasium majus L. (Pm) were collected, assessed for their metabolite content, and evaluated for potential applications in agriculture and medicine. The HPLC-MS analysis of n-hexane (HE) and CH2Cl2 (MC) extracts and the residual aqueous phases (WR) showed the presence of several metabolites in both organic extracts. Crude HE and MC extracts from Dl and He significantly inhibited butyrylcholinesterase, as did WR from the extraction of Dl and Pa. HE and MC extracts showed a significant toxicity towards hepatocarcinoma Huh7, while Dl, Ha and Er HE extracts were the most potently cytotoxic to ileocecal colorectal adenocarcinoma HCT-8 cell lines. Most extracts showed antiviral activity. At the lowest concentration tested (1.56 μg/mL), Dl, Gf and Ap MC extracts inhibited betacoronavirus HCoV-OC43 infection by> 2 fold, while the n-hexane extract of Pm was the most potent. In addition, at 1.56 μg/mL, potent inhibition (>10 fold) of dengue virus was detected for Dl, Er, and Pm HE extracts, while Pa and Ap MC extracts dampened infections to undetectable levels. Regarding to phytotoxicity, MC extracts from Er, Ap and Pm were more effective in inhibiting tomato rootlet elongation; the same first two extracts also inhibited seed cress germination while its radicle elongation, due to high sensitivity, was affected by all the extracts. Es and Gf MC extracts also inhibited seed germination of Phelipanche ramosa. Thus, we have uncovered that many of these Lampedusa plants displayed promising biopesticide, antiviral, and biological properties.
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Soares, Nathalia da Costa Pereira, Monique de Barros Elias, Clara Lima Machado, Bruno Boquimpani Trindade, Radovan Borojevic, and Anderson Junger Teodoro. "Comparative Analysis of Lycopene Content from Different Tomato-Based Food Products on the Cellular Activity of Prostate Cancer Cell Lines." Foods 8, no. 6 (June 10, 2019): 201. http://dx.doi.org/10.3390/foods8060201.
Full textAbstract:
Lycopene is more bioavailable in processed tomato products than in raw tomatoes, since arrangement of cis-isomers of lycopene during food processing and storage may increase its biological activity. The aim of the study is evaluate the influence of lycopene content from different tomato-based food products (extract, paste, ketchup and sauce) on cell proliferation, cell cycle, and rate of apoptosis of human prostate cancer cell lines. DU-145 and PC-3 cell lines were treated with lycopene content from different tomato-based food products (500–5000 μg/mL) for 96 h. The data showed a decrease in cell viability in both DU-145 and PC-3 cells after treatment with all lycopene extracts from tomato-based food products. Analysis of cell cycle revealed a decrease in the percentage of prostate cancer cells in G0/G1 and G2/M phases after 96 h of treatment when using lycopene content from tomato paste and tomato extract. However, lycopene extracted from tomato sauce and ketchup promoted a decrease in the percentage of cells in G0/G1 phase and an increase in S and G2/M phases after 96 h of treatment. Lycopene content from all of those tomato-based food products also increased apoptosis in both prostate cancer cell lines. In this regard, lycopene has proved to be a potent inhibitor of cell viability, arrest cell cycle and increase the apoptosis in human prostate cancer cells, suggesting an effect in the balance of human prostate cancer cell lines growth.
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Kucuk, Omer, Fazlul H. Sarkar, Wael Sakr, Fred Khachik, Zora Djuric, Mousumi Banerjee, Michael N. Pollak, John S. Bertram, and David P. Wood. "Lycopene in the treatment of prostate cancer." Pure and Applied Chemistry 74, no. 8 (January 1, 2002): 1443–50. http://dx.doi.org/10.1351/pac200274081443.
Full textAbstract:
Dietary intake of lycopene is associated with reduced risk of prostate cancer (PCa). We conducted a clinical trial in men with prostate cancer to investigate the biological and clinical effects of lycopene supplementation. Twenty-six men with prostate cancer were randomly assigned to receive a lycopene supplement or no supplement for three weeks before radical prostatectomy. Subjects in the intervention group (n = 15) were instructed to take a tomato oleoresin extract soft gel capsule (Lyc-O-Mato®, LycoRed Company, Beer Sheva, Israel) containing 15 mg lycopene, 1.5 mg phytoene, 1.5 mg phytofluene, and 5 mg tocopherol twice daily with meals. Prostatectomy specimens were evaluated for pathologic stage, Gleason score, volume of cancer, and extent of high-grade prostatic intraepithelial neoplasia (HGPIN). Biomarkers of cell proliferation and apoptosis were assessed by Western blot analysis in benign and cancerous tissue samples obtained from the prostatectomy specimens. Oxidative stress was assessed by measuring the peripheral blood lymphocyte DNA oxidation product 5-hydroxymethyl-deoxyuridine (5-OH-mdU). Plasma levels of lycopene, insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and prostate-specific antigen (PSA) were measured at baseline and after three weeks of study period. After the intervention, more men in the intervention group had smaller (<4 cc) tumors, organ-confined disease without involvement of surgical margins or extra-prostatic tissues, and focal involvement of the prostate with HGPIN compared to the control group. Mean plasma PSA levels were lower in the intervention group compared to the control group. This pilot study suggests that a tomato extract containing lycopene and other tomato carotenoids and phytochemicals may have a potential role in the treatment of prostate cancer. Larger clinical trials are necessary to definitively address potential uses of lycopene or tomato extract in the prevention or treatment of prostate cancer.
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Barus, Bunga Rimta, Vera Estevania Kaban, Jessi Octavia Aitonang, and Syukur Berkat Waruwu. "PERBANDINGAN FORMULASI EKSTRAK E PERBANDINGAN FORMULASI EKSTRAK ETANOL BUAH TERONG BELANDA SEBAGAI PEWARNA PADA BLUSH ON DALAM BENTUK SEDIAAN COMPACT." JURNAL FARMASIMED (JFM) 3, no. 1 (October 30, 2020): 6–10. http://dx.doi.org/10.35451/jfm.v3i1.450.
Full textAbstract:
Blush on is a cosmetic preparation for coloring the cheeks with an artistic touch so that it can increase the attractive impression in makeup (Nurhayati, 2016). Many blush-on preparations come from chemicals, which can cause spotty, black spots and can trigger skin cancer. One alternative that can be used is by making a blush on natural ingredients, namely Tree Tomato. The purpose of this study was to find out the Ethanol Extract of the Tree Tomato Fruit was made as a blush on coloring in compact preparations.The sample used in this study was Tree Tomato, red and had a soft texture taken from the cultivation of Tree tomato in the village of Brastagi, Karo District, North Sumatra Province. Making extracts is done by maceration and the process of making blush. After that evaluation of blush on preparation is carried out. Evaluation test results of blush on ethanol extract of tree tomato fruit include. The results of homogeneity tests are declared homogeneous, pH test averages 6.4, irritation test results stated not to irritate, the test results of the three formulations can be concluded that the three most preferred form of blush on panelists are formulations with a concentration of 15%, because they have a comfortable level of application, clear colors and very soft.Ethanol extract of Tree Tomato fruit can be made as a dye in compact preparations.
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Koul, Ashwani, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, and Neha Arora Chugh. "Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice." International Journal for Vitamin and Nutrition Research 90, no. 5-6 (October 2020): 493–513. http://dx.doi.org/10.1024/0300-9831/a000597.
Full textAbstract:
Abstract. The present study revealed the effects of Lycopene enriched tomato extract (LycT) on chemically induced skin cancer in mice. Skin tumors were induced by topical application of 7,12-Dimethylbenz(a)anthracene (DMBA) [500 nmol/100 ul of acetone, twice a week for two weeks] and 12-O-tetradecanoyl phorbol-13-acetate (TPA) [1.7 nmol/100 ul of acetone, twice a week for eighteen weeks] and LycT (5 mg/kg b.w.) was administered orally. Male Balb/c mice were divided into four groups (n = 15 per group): control, DMBA/TPA, LycT and LycT + DMBA/TPA. The chemopreventive response of LycT to skin tumorigenesis was evident by inhibition in tumor incidence, number, size, burden and volume in LycT + DMBA/TPA group when compared to DMBA/TPA group. This was associated with inhibition of cell proliferation in LycT + DMBA/TPA group as observed by the decrease in epidermal morphometric parameters and mRNA and protein expression of proliferating cell nuclear antigen when compared to DMBA/TPA group (p ≤ 0.05). LycT decreased (p ≤ 0.05) the mRNA and protein expression of angiogenic genes (vascular endothelial growth factor, angiopoietin-2, basic fibroblast growth factor) in LycT + DMBA/TPA group, suggesting its anti-angiogenic effects. The increase (p ≤ 0.05) in protein expression of connexin-32 and 43 in LycT + DMBA/TPA group suggests improved inter cellular communication when compared to DMBA/TPA group. Histochemical studies demonstrated that the components of extracellular matrix (fibrous proteins and mucopolysaccharides) were also modulated during skin carcinogenesis and its chemoprevention by LycT. The decrease in cell proliferation parameters and expression of angiogenesis associated genes, modulation of ECM components and increase in expression of connexins suggest that LycT improved multiple dysregulated processes during chemoprevention of skin cancer.
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Nguenang, Gaëlle S., Arsène S. M. Ntyam, and Victor Kuete. "Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential." Evidence-Based Complementary and Alternative Medicine 2020 (March 5, 2020): 1–10. http://dx.doi.org/10.1155/2020/8935897.
Full textAbstract:
Lycopersicon esculentum (tomato) is a plant widely used in Africa like food and to solve many health problems. The methanol crude extract of tomato recently demonstrated a good antiproliferative effect on many human cancer cell lines. The aim of this research was to evaluate the acute toxicity and subacute oral toxicity of methanolic extract from leaves of this plant. These toxicities were evaluated based on the OECD (Organization for Economic Cooperation and Development) guidelines. The assay of acute toxicity was performed using a total of 3 female rats, which received a single dose of 5000 mg/kg of methanolic extract via oral gavage. For the subacute toxicity study, 32 Wistar rats (males and females) were used. The groups were treated with three different doses of Lycopersicon esculentum methanolic extract (250, 500, and 1000 mg/kg b.w.) for 28 days and the control group received distilled water. The hematological, biochemical, and histopathological studies were performed after the sacrifice. Single dose of tomato extract caused no toxicity up to a dose of 5000 mg/kg body weight; hence, the median lethal dose (DL50) of leaves of this plant was greater than this value. However, lower toxic effects could be manifested in the long-term treatment at the highest dose (1000 mg/kg) because urea level and total serum proteins significantly increased at a dose of 1000 mg/kg with respect to control. The microscopic observation showed no remarkable pathological changes on all organs in the treated groups compared with the control groups of female and male rats. These results demonstrate that single dose of tomato extract leaves is relatively nontoxic at a dose of 5000 mg/kg b.w. and prolonged use of lower doses (250 and 500 mg/kg) of L. esculentum orally should be encouraged, whereas highest dose (1000 mg/kg) should be avoided.
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Fujimaki, Junya, Neo Sayama, Shigenobu Shiotani, Takanori Suzuki, Miki Nonaka, Yasuhito Uezono, Mamoru Oyabu, et al. "The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes." Nutrients 14, no. 5 (February 28, 2022): 1023. http://dx.doi.org/10.3390/nu14051023.
Full textAbstract:
The steroidal alkaloid tomatidine is an aglycone of α-tomatine, which is abundant in tomato leaves and has several biological activities. Tomatidine has been reported to inhibit the growth of cultured cancer cells in vitro, but its anti-cancer activity in vivo and inhibitory effect against gastric cancer cells remain unknown. We investigated the efficacy of tomatidine using human gastric cancer-derived 85As2 cells and its tumor-bearing mouse model and evaluated the effect of tomatidine-rich tomato leaf extract (TRTLE) obtained from tomato leaves. In the tumor-bearing mouse model, tumor growth was significantly inhibited by feeding a diet containing tomatidine and TRTLE for 3 weeks. Tomatidine and TRTLE also inhibited the proliferation of cultured 85As2 cells. Microarray data of gene expression analysis in mouse tumors revealed that the expression levels of mRNAs belonging to the type I interferon signaling pathway were altered in the mice fed the diet containing tomatidine and TRTLE. Moreover, the knockdown of one of the type I interferon-stimulated genes (ISGs), interferon α-inducible protein 27 (IFI27), inhibited the proliferation of cultured 85As2 cells. This study demonstrates that tomatidine and TRTLE inhibit the tumor growth in vivo and the proliferation of human gastric cancer-derived 85As2 cells in vitro, which could be due to the downregulation of ISG expression.
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Urbonavičienė, Dalia, Česlovas Bobinas, Ramunė Bobinaitė, Lina Raudonė, Sonata Trumbeckaitė, Jonas Viškelis, and Pranas Viškelis. "Composition and Antioxidant Activity, Supercritical Carbon Dioxide Extraction Extracts, and Residue after Extraction of Biologically Active Compounds from Freeze-Dried Tomato Matrix." Processes 9, no. 3 (March 5, 2021): 467. http://dx.doi.org/10.3390/pr9030467.
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Supercritical carbon dioxide extraction (SCE-CO2) is an attractive, green technology that is used for the recovery of biologically active compounds from plant material. The antioxidant potential of lipophilic fractions (extract obtained with SCE-CO2) and hydrophilic fractions (extracts obtained from the residue after extraction) obtained from a matrix of freeze-dried tomatoes (cvs. “Admiro” F1, “Jurgiai”, “Vilina”, “Pirmutis”, and “Skariai”) was assessed via different antioxidant activity methods. The total amount of polyphenols, carotenoids, and carotenoid isomers before and after SCE-CO2 extraction was also determined. To investigate the effect of the SCE-CO2 extract on the viability of cancer cells, rat glioblastoma C6 cells were chosen. The SCE-CO2 yielded an average of 800 mg of lipophilic fraction per 100 g of freeze-dried tomatoes. The ABTS•+ scavenging activity of the extract was 251 ± 3.4 µmol TE/g. After SCE-CO2 extraction, the DPPH•-RSA of the freeze-dried tomato matrix was 7 to 12% higher. There was a strong positive correlation (R = 0.84) between the total polyphenolics content and the DPPH•-RSA of the tomato samples. The SCE-CO2 increased the radical scavenging activity of the extraction residue, indicating that a considerable fraction of the hydrophilic compounds with particular antioxidant capacity remain unextracted from the tomato matrix. Our results reveal the cytotoxic effect of lycopene extract rich in cis-isomers (62% cis-isomers of the total lycopene content) on rat glioblastoma C6 cells. The viability of the glioblastoma C6 cells significantly decreased (−42%) at a total lycopene concentration of 2.4 µM after 24 h of incubation.
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Walfisch, Shlomo, Yossi Walfisch, Elena Kirilov, Nadia Linde, Haim Mnitentag, Riad Agbaria, Yoav Sharoni, and Joseph Levy. "Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients." European Journal of Cancer Prevention 16, no. 4 (August 2007): 298–303. http://dx.doi.org/10.1097/01.cej.0000236251.09232.7b.
Full textDissertations / Theses on the topic "Colorectal cancer, tomato, tomato extract"
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PENON, ANTONELLA, and ANTONIO GIORDANO. "BIOLOGICAL EFFECTS OF CORBARINO TOMATO LIPOPHILIC EXTRACT AND ITS PROCESSED FORM ON COLORECTAL CANCER CELL LINES AND RELATED MOLECULAR PATHWAY INVOLVED." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1009543.
Full textAbstract:
Colorectal cancer is one of the most common causes of cancer death in the Western world. Most of the colon tumors are sporadic and develop somatically in epithelial cells. Apart from genetic factors, nutritional factors can markedly affect tumor development. In particular, while a high intake of red meat and animal fat is considered key points predisposing to colorectal cancer development, epidemiological studies often observed an inverse correlation between tomato and tomato product (sauce, paste) consumption and colon cancer risk. Tomato antioxidant bioactive molecules such as carotenoids and polyphenols could be responsible, at least in part, for the healthy effect. Here we analyzed the effect of total lipophilic extracts of a Southern Italy tomato variety, Corbarino and its processed form, Corbarino sauce, on two in vitro model of human colorectal adenocarcinoma cell lines, Colo–320 and SW-480, characterized by different aggressiveness. Our results support the hypothesis of a role for this variety of tomato in the inhibition of some features involved in the neoplastic advancement. The treatment with tomato extracts affected cancer cell ability to grow both in adherence and in semisolid medium, reducing also cell migration ability as highlighted after 24 hrs and more relevant results were gained after 72 hrs of incubation. Moreover, the most effective results were obtained with Corbarino sauce extract. No toxic effects were observed on non-tumoral cells, Human Skin Fibroblasts (HSFs). The observed inhibition of cancer cell growth and aggressiveness is associated with a negative regulation of cell cycle progression as pointed out by the increased expression levels of pRb/p105, p107 and pRb2/p130 while p21-Cip1 and p27-Kip1 expression levels decreased. The extent of antineoplastic effects, furthermore, seem to be correlated with the antioxidant activity of the two tomatoes form. Our data indicate that Corbarino tomato and its processed form intake might be further considered as nutritional support not only in cancer prevention, but also for cancer patient diet
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Fulco, Beniamino. "Preventive and antiproliferative effects of tomato extracts on colorectal cancer." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1144767.
Full textAbstract:
Colorectal cancer represents the third most common cancer and the fourth cause for cancer death in both sexes worldwide. Different epidemiological and observational evidences strictly correlated the risk of colorectal cancer to lifestyle, especially to diet. Numerous studies have investigated the effect of antioxidant substances derived from food but data on lycopene or tomato extracts are still rare. This project is based on comparing the effects of extracts (total and lipophilic fractions) obtained from fresh tomato of one tomato cultivar (corbarino) versus another tomato variety (tangerino), this latter known to have lycopene already in bioactive isoform. Using two colorectal carcinoma cell lines we previously investigated the ability of tomatoes to inhibit cancer cell growth and proliferation and hypothesized a selective action on cancer cells and a lack of an effect on non-cancer cells (normal human fibroblasts). We noticed a major effect of tangerino tomato extracts, particularly of total fraction. These data made us hypothesize a possible effect of tomato extract on cell cycle. We analyzed cell cycle progression by flow cytometry. Data obtained showed that there are not great differences between treatment and control, but we noticed different peaks in sub G0/G1 phase, suggesting a possible cellular death via apoptosis. At the molecular level, we found variation in the expression of different proteins (RBL1, RBL2, pAKT, p21cip1, p27kip1, etc) involved in different cellular mechanisms. Based on the known anti-inflammatory effect of lycopene, we also performed a western blot for IL6 and IL10 to understand if tomato extracts have an impact on the inflammation process. Data showed a reduction of IL6 and a small increase of IL10 levels, compatible with an anti-inflammatory action.
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D'Angelo, Costantino. "Evaluation of anti-proliferative and antioxidant potential of tomato extract against melanoma." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1133306.
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Abstract
Melanoma is a form of skin cancer occurring prevalently, in fair-skinned and lighthaired person; its incidence is constantly increasing and in Italy is the second most
frequent cancer males under 50 and third most frequent in female under 50 years.
Increasing evidences are demonstrating that antioxidants from vegetables have both
antriproliferative activity and ratio-sensiting property on cancer cell. Here, we will
investigate the anti-proliferative and ratio-sensitizing potential of polyphenolic fraction
from different tomato cultivars in melanoma cells lines. Aim of this work is to expand
the existing knowledge on the effects of anti-oxidants and antiproliferative on
melanoma cancer cells. The melanoma cancer cell line we used for this study is M14
with mutation in the BRAF gene which is involved in cancer drug resistance.
Polyphenolic fraction obtained from our tomatoes extracts has been examined for
identification of polyphenols by High Performance Liquid Chromatography technology,
and we will study the effects of these compounds on the main pathways to be
deregulated in cancer (Rb2, p21/Cip1 and p27/Kip1), according with our published results.
Cytotoxicity assay, western blot, qRT-PCR, cell cycle analysis and will be performed to
study the impact of these compouds on melanoma cells biology. In the second part of
this work we evaluated also the capacity to inhibition of UV-A induced ROS generation
in fibroblast cell by tomato extract and the ability to screen UV light and to reduce the
harm to DNA caused by free oxygen radicals.