Academic literature on the topic 'Colon'

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Journal articles on the topic "Colon"

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Olegovich, Ten Dmitry. "Results Of Colon Anastomosis Formation After Sigmoid Colon Resection." American Journal of Medical Sciences and Pharmaceutical Research 02, no. 07 (July 30, 2020): 31–37. http://dx.doi.org/10.37547/tajmspr/volume02issue07-05.

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Spencer, Nick J., Melinda Kyloh, David A. Wattchow, Anthony Thomas, Tiong Cheng Sia, Simon J. Brookes, and Sarah J. Nicholas. "Characterization of motor patterns in isolated human colon: are there differences in patients with slow-transit constipation?" American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 1 (January 2012): G34—G43. http://dx.doi.org/10.1152/ajpgi.00319.2011.

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The patterns of motor activity that exist in isolated full-length human colon have not been described. Our aim was to characterize the spontaneous motor patterns in isolated human colon and determine whether these patterns are different in whole colons obtained from patients with slow-transit constipation (STC). The entire colon (excluding the anus), was removed from patients with confirmed STC and mounted longitudinally in an organ bath ∼120 cm in length, containing oxygenated Krebs' solution at 36°C. Changes in circular muscle tension were recorded from multiple sites simultaneously along the length of colon, by use of isometric force transducers. Recordings from isolated colons from non-STC patients revealed cyclical colonic motor complexes (CMCs) in 11 of 17 colons, with a mean interval and half-duration of contractions of 4.0 ± 0.6 min and 51.5 ± 15 s, respectively. In the remaining six colons, spontaneous irregular phasic contractions occurred without CMCs. Interestingly, in STC patients robust CMCs were still recorded, although their CMC pacemaker frequencies were slower. Intraluminal balloon distension of the ascending or descending colon evoked an ascending excitatory reflex contraction, or evoked CMC, in 8 of 30 trials from non-STC (control) colons, but not from colons obtained from STC patients. In many control segments of descending colon, spontaneous CMCs consisted of simultaneous ascending excitatory and descending inhibitory phases. In summary, CMCs can be recorded from isolated human colon, in vitro, but their intrinsic pacemaker frequency is considerably faster in vitro compared with previous human recordings of CMCs in vivo. The observation that CMCs occur in whole colons removed from STC patients suggests that the intrinsic pacemaker mechanisms underlying their generation and propagation are preserved in vitro, despite impaired transit along these same regions in vivo.
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Schusser, Gerald F., and Nathaniel A. White. "Morphologic and quantitative evaluation of the myenteric plexuses and neurons in the large colon of horses." Journal of the American Veterinary Medical Association 210, no. 7 (April 1, 1997): 928–34. http://dx.doi.org/10.2460/javma.1997.210.07.928.

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Objective— To determine the number of myenteric plexuses and neurons in the large colon of clinically normal horses and whether the number was decreased in the large colon of horses with colon disease. Design— Prospective study. Sample Population— Colon samples from 15 clinically normal horses and 31 horses with colon disease. Procedure— Samples were obtained, fixed, and stained with H&E. The number of myenteric plexuses and neurons and longitudinal muscle thickness were determined in each segment of colon for clinically normal horses. Counts for segments were compared with each other and with counts in the same segment from horses with colon disease. Results— Myenteric plexus and neuron densities and longitudinal muscle thickness in clinically normal horses were significantly greater in the pelvic flexure and left dorsal and transverse colons. Horses with chronic obstruction (> 24 hours' duration) or with previous obstruction had significantly lower neuron density in the pelvic flexure. Myenteric plexus density in horses with strangulating large colon torsion/volvulus was significantly less in the right ventral, right dorsal, and transverse colons, and neuron density in these horses was significantly less in all segments of colon, except the left ventral colon. Horses with colon strangulation that survived had significantly greater neuron density than horses with colon strangulation that died. Enteroglial cell numbers were increased in myenteric plexuses of horses with acute and chronic obstruction. Clinical Implications— Myenteric plexus and neuron densities can be estimated by evaluating linear counts of H&E-stained colon samples. Enteroglial cells may increase in number in response to myenteric plexus inflammation, which may affect bowel function. (J Am Vet Med Assoc 1997;210:928–934)
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Holmqvist, O. H. "Colon heat and colon cancer." Medical Hypotheses 54, no. 3 (March 2000): 469–71. http://dx.doi.org/10.1054/mehy.1999.0878.

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Serrano-Morales, José M., María D. Vázquez-Carretero, Pablo García-Miranda, Ana E. Carvajal, María L. Calonge, Anunciación A. Ilundain, and María J. Peral. "Reelin Protects Against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression." Biology 11, no. 10 (September 26, 2022): 1406. http://dx.doi.org/10.3390/biology11101406.

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Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions to colon cancer and tried to elucidate reelin regulation under these transition processes. Samples of healthy and pathological colons from humans and mice treated with either azoxymethane/dextran sulfate sodium (DSS) or azoxymethane alone were used. The relative abundances of reelin, DNMT-1 and ApoER2 mRNAs were determined by PCR in the colon samples cited above and in the tissue adjacent to mouse colon polyps and adenocarcinomas. In both, humans and mice, reelin mRNA abundance increased significantly in ulcerative colitis and slightly in polyps and decreased in adenomas and adenocarcinomas. Reelin expression was higher in the tissue adjacent to the colon adenocarcinoma and lower in the lesion itself. The reelin expression changes may result, at least in part, from those in DNMT-1 and appear to be independent of ApoER2. Lack of reelin downregulated p-Akt and p53 in healthy colon and prevented their increases in the inflamed colon, whereas it increased GSK-3β in DSS-untreated mice. In conclusion, reelin mRNA abundance depends on the severity of the colon pathology, and its upregulation in response to initial injuries might prevent the beginning of colon cancer, whereas reelin repression favors it. Increased p53 expression and activation may be involved in this protection. We also propose that changes in colon reelin abundance could be used to predict colon pathology progression.
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Gao, Chang, Rui Sun, Ya-Rong Xie, An-Li Jiang, Mei Lin, Min Li, Zheng-Wang Chen, Ping Zhang, Honglin Jin, and Jue-Ping Feng. "The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo." Experimental Biology and Medicine 242, no. 10 (March 1, 2017): 1034–43. http://dx.doi.org/10.1177/1535370217697383.

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Vglycin, a novel natural polypeptide isolated from pea seeds, possesses antidiabetic properties. Our previous studies have shown that Vglycin can induce the differentiation of human colon adenocarcinoma cells. We aimed to determine the anticancer activity of Vglycin against colon cancer cells and to elucidate related apoptosis-inducing mechanisms. Treatment with purified Vglycin significantly reduced growth, viability, and colony formation of CT-26, SW480, and NCL-H716 colon cancer cells in a dose-dependent manner while down-regulating the expression of proliferating cell nuclear antigen. Mouse xenograft studies showed a 38% inhibition of colon cancer growth in mice treated with Vglycin (20 mg/kg/day) at day 21. Furthermore, the potential mechanisms involved in Vglycin-induced cell apoptosis were examined using cell cycle studies, ultrastructural examination, as well as apoptosis-associated pathway analysis. The results showed that Vglycin significantly promoted apoptosis and G1/S phase cell cycle arrest. As revealed by Western blot, the expression of CDK2 and Cyclin D1 was down-regulated in all three Vglycin-treated colon cancer cells, indicating that the CDK2/Cyclin D1 cell cycle pathway involved in the initiation and progression of colon cancer. Moreover, the inhibition of Vglycin-induced cell proliferation in colon cancer cells was accompanied by alteration of the expression levels of the apoptosis-related proteins Bax, Bcl-2 and Mcl-1, and an increase of caspase-3 activity. Together, our results suggest that Vglycin may be another plant-derived peptide that suppresses colon cancer, supporting the continued investigation of Vglycin as therapeutic agent for colon cancer. Impact statement The antidiabetic properties and the capability of inducing differentiation of human colon adenocarcinoma cells of Vglycin have been reported in our previous studies. However, the anticancer potential of Vglycin on colon cancer cells and its possible related mechanisms were still unknown. In this study, we found that Vglycin could reduce growth, viability, and colony formation or colony size of CT-26, SW480, and NCL-H716 colon cancer cells. Moreover, Vglycin decreased tumor volume by 38% in xenograft mice transplanted with CT-26 cells. The mechanisms of these phenomena may be due to the down-regulated CDK2 and Cyclin D1, G1/S phase cell cycle arrest, and the dysregulated expression of Bax, Bcl-2, and Mcl-1. The findings highlight the anticancer potential of Vglycin against colon cancer cells, and suggest Vglycin may be another colon cancer potential suppressive component of plant-derived peptides.
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Liu, Y., H. Huang, B. Yuan, L. Zhuang, T. Luo, and Q. Zhang. "Lentivirus-Mediated Knockdown of NOB1 Suppresses the Proliferation of Colon Cancer Cells." Zeitschrift für Gastroenterologie 52, no. 05 (May 2014): 429–35. http://dx.doi.org/10.1055/s-0033-1356338.

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AbstractNOB1 is important for ribosome biogenesis and protein degradation. Previous studies showed that it could regulate the growth and colony-formation ability of ovarian, breast and hepatocellular carcinoma cells. However, its function in colon cancer cells is largely unknown. In this study, we found that NOB1 could express in 6 different colon cancer cell lines. Lentivirus-mediated shRNA targeted NOB1 could suppress the endogenous gene expression. NOB1 depletion significantly inhibited cell proliferation and colony formation ability, as determined by MTT and colony formation assays. Flow cytometry analysis showed NOB1 silencing arrested cell cycle in G0 / G1 phase. Moreover, the percentage of cells at sub-G1 phase dramatically increased after NOB1 knockdown. These results indicate that NOB1 may play an important role in the growth and tumorigensis of colon cancer and knockdown of NOB1 may be a potential therapeutic method for colon cancer in the future.
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Phillips, M., A. Patel, P. Meredith, O. Will, and C. Brassett. "Segmental colonic length and mobility." Annals of The Royal College of Surgeons of England 97, no. 6 (September 1, 2015): 439–44. http://dx.doi.org/10.1308/003588415x14181254790527.

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Introduction Locoregional variation in the human colon is important in surgical practice; the length and mobility of different colonic regions impacts on laparoscopic and endoscopic colorectal procedures. The aim of this study was to refine anatomical understanding of the colon in terms of segmental length and mobility. Methods The colons of 35 cadavers were examined to determine lengths of caecum as well as ascending, transverse, descending and rectosigmoid colon, and to characterise colonic mobility at each location in terms of the mesenteric attachments. The presence of Jackson’s membrane (a congenital peritoneal band of the right colon) was also documented. Results The mean total colonic length was 131.2cm (standard deviation [SD]: 13.4cm). There was no correlation with height, age or sex; the best predictor of total colonic length was the length of the rectosigmoid segment. The mean height of the transverse mesocolon was 7.4cm (SD: 3.6cm) and that of the sigmoid mesocolon was 6.3cm (SD: 2.6cm). Two-thirds of the subjects had a mobile portion of the ascending colon and nearly one-third had a mobile descending colon. A mobile ascending colon was significantly more common in females. Jackson’s membrane was present in 66% of the subjects. Conclusions This cadaveric study suggests that rectosigmoid length accounts for most of the variability in total colonic length. The significant proportion of colons with mobility of the ascending and descending segments prompts revision of the traditional anatomical teaching of these segments as fixed and retroperitoneal. Mobility of the ascending colon may account for the anecdotal finding that colonoscopy is more challenging in female patients. Jackson’s membrane was identified in most colons.
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Wiese, Maria, Yan Hui, Dennis S. Nielsen, Andrew R. Williams, Julie C. Lynegaard, Nicolai R. Weber, and Charlotte Amdi. "Color of Colon Content of Normal and Intrauterine Growth-Restricted Weaned Piglets Is Associated with Specific Microbial Taxa and Physiological Parameters." Animals 10, no. 6 (June 22, 2020): 1073. http://dx.doi.org/10.3390/ani10061073.

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A well-balanced gut microbiome is associated with improved health outcomes, but to date, the GM of IUGR piglets have only been sparsely investigated. Here, we investigated GM composition, color of colon content, and blood parameters of 20 IUGR and 20 normal 24-day-old piglets. No significant differences were detected in colon microbiota composition between IUGR and the normal piglets with respect to alpha and beta diversity measures. The colon content of these piglets displayed three colors: brown, black, and yellow. Interestingly, the color of the colon content varied with microbial community composition, with significant differences in the relative abundance of taxa belonging to Fusobacteria and Treponema. Fusobacteria were most abundant in yellow fecal samples, with a mean relative abundance around 5.6%, whereas this was 0.51% within brown and 0.02% for the black fecal samples. Fusobacteria positively correlated with total blood protein, albumin, and triglycerides. Contrarily, Treponema was at 0.9% the most abundant in black fecal samples, while present at 0.1% of relative abundance in brown fecal samples and 0.01% in yellow samples, correlating positively with blood iron content. This study indicates that colon/fecal content color can be used as indicator for specific GM and metabolite signatures.
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Eluru, Jagadeesh Reddy, and Kailasam Koumaravelou. "Evaluation of aqueous and hydro alcoholic extracts of Clerodendrum viscosum V. leaves & Macrotyloma uniflorum L. seeds against DMH-induced colon cancer." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (March 12, 2018): 174. http://dx.doi.org/10.26452/ijrps.v9i1.1227.

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Evaluation of anti-neoplastic activity of aqueous and hydro alcoholic extracts of Clerodendron viscosum V. leaves & Macrotyloma uniflorum L. seeds against DMH-induced colon cancer is the objective of this study. Extracts were obtained using cold maceration process. Six groups of animals, each containing ten male albino wistar rats (80 – 100 g) were administered with respective treatment to evaluate the anti-neoplastic activity. On the last day of experimental period, fecal matter was collected and colons were removed. Fecal matter was homogenized, and subjected to the measurement of fecal pH and bacterial enzymes. Colons of five animals were subjected for the presence of MPLs, ACFs in each colon, and histopathology by using standard methodology. Colons of remaining five animals were subjected to homogenization to measure the bacterial enzymes such as β-Glucosidase, β-Glucuronidase, and mucinase. The extracts showed significant protective effect by showing significant decrease in the levels of fecal and colon β-glucosidase, β-glucuronidase, mucinase; reduction in total number of ACFs in each colon and crypt multiplicity. Although, all the plant extracts has shown protective effect against colon carcinogenesis, treatment with hydro alcoholic extracts has produced more pronounced effect as compared with aqueous extracts.
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Dissertations / Theses on the topic "Colon"

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Kaiser, Sergio, Young-Kyu Park, Jeffrey Franklin, Richard Halberg, Ming Yu, Walter Jessen, Johannes Freudenberg, et al. "Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer." BioMed Central, 2007. http://hdl.handle.net/10150/610145.

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BACKGROUND:The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5.RESULTS:We report here that 39 colon tumors from four independent mouse models and 100 human CRCs encompassing all clinical stages shared a striking recapitulation of embryonic colon gene expression. Compared to normal adult colon, all mouse and human tumors over-expressed a large cluster of genes highly enriched for functional association to the control of cell cycle progression, proliferation, and migration, including those encoding MYC, AKT2, PLK1 and SPARC. Mouse tumors positive for nuclear beta-catenin shifted the shared embryonic pattern to that of early development. Human and mouse tumors differed from normal embryonic colon by their loss of expression modules enriched for tumor suppressors (EDNRB, HSPE, KIT and LSP1). Human CRC adenocarcinomas lost an additional suppressor module (IGFBP4, MAP4K1, PDGFRA, STAB1 and WNT4). Many human tumor samples also gained expression of a coordinately regulated module associated with advanced malignancy (ABCC1, FOXO3A, LIF, PIK3R1, PRNP, TNC, TIMP3 and VEGF).CONCLUSION:Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis. This approach also provides a general method for identifying pattern-specific biomarkers and therapeutic targets. This delineation and categorization of developmental and non-developmental activator and suppressor gene modules can thus facilitate the formulation of sophisticated hypotheses to evaluate potential synergistic effects of targeting within- and between-modules for next-generation combinatorial therapeutics and improved mouse models.
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Kelleher, Sarah A. "Colon Cancer Survivorship Experiences." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/36209.

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The purpose of this project is to explore potential social cognitive and psychosocial predictors of lifestyle changes, including diet and physical activity behaviors, in a sample of colorectal cancer survivors who are at high risk of developing a second colorectal cancer. Participants, recruited from Georgetown Universityâ s Lombardi Comprehensive Cancer Center, are colorectal cancer survivors from families at high or confirmed risk of having a hereditary colorectal cancer syndrome. Results indicate that, at the bivariate level, many of the psychosocial and social cognitive variables of interest are significantly associated with one another as well as with various health behaviors and health behavior changes. Correlational data indicate that lower distress is associated with higher psychosocial functioning, self-efficacy, and self-regulatory ability. In addition, the data also suggest that individuals with higher self-efficacy display higher self-regulation and more positive outcome expectations related to health behaviors. Overall, participants were more likely to increase healthy behaviors or remain consistent with moderately healthy lifestyles practiced prior to their colorectal cancer diagnosis and treatment, and decrease unhealthy behaviors. Implications and directions for future research are discussed within the paper.
Master of Science
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Pereira, Yara Emantne Amaral. "Influencia do choque hemorragico na anastomose de colon sigmoide em ratos : avaliação com teste de resistencia a pressão de ruptura." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308756.

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Orientadores: Claudio Saddy Rodrigues Coy, João Jose Fagundes
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-09T01:10:44Z (GMT). No. of bitstreams: 1 Pereira_YaraEmantneAmaral_M.pdf: 1682869 bytes, checksum: 9d5801f67ab43156ce97cd3a10778b4d (MD5) Previous issue date: 2007
Resumo: Introdução: As complicações das anastomoses intestinais podem ser graves com altos índices de morbi/mortalidade. Vários fatores relacionados à qualidade das mesmas têm sido objetos de estudos, como técnica operatória, fios de sutura ou variáveis bioquímicas, enquanto que outros, não associados diretamente à técnica cirúrgica, são menos avaliados, como por exemplo, a influência de choque hemorrágico. Objetivo: Avaliar o efeito do choque hemorrágico em anastomoses de cólon em ratos, com teste de ruptura à distensão por líquido. Material e Método: Foram utilizados ratos da linhagem Wistar, com idade aproximada de 90 dias e peso variando de 310 gramas a 380 gramas. Os animais foram divididos em dois grupos, sendo o grupo G1, composto por 10 animais submetidos à anastomose de cólon em condições de normovolemia e o grupo G2, composto por 10 animais submetidos à anastomose de cólon em condições de hipovolemia. O choque foi instalado através da retirada de meio mililitro de sangue a cada dois minutos, até que se atingissem valores de pressão arterial média (PAM) de 50mmHg ou volume total de retirada correspondente a 30% da volemia. Foram realizadas dosagens séricas de lactato (mmol/l) no início do procedimento e ao término do mesmo. Os valores séricos médios de lactato ao término da cirurgia foram de 1,91 mMol/l no grupo G1 e de 3,69 mMol/l no grupo G2 (p<0,05) No quinto dia de pós-operatório, os animais foram submetidos à eutanásia e tiveram suas anastomoses testadas por teste de resistência à pressão de ruptura à distensão por líquido. Resultados: No grupo G1, o valor médio da pressão de ruptura do cólon à distensão por líquido foi de 160,7 mmHg enquanto que no grupo G2 foi de 152,1mmHg (p>0,05). Conclusão: A presença de choque hemorrágico, nas condições estabelecidas neste estudo, não exerceu influência em anastomoses de cólon em ratos, avaliadas com teste de ruptura à distensão por líquido
Abstract: Introduction: Intestinal anastomoses complications can be very serious, with high morbidity and mortality rates. Several factors related to their quality have been object of studies, such as technical aspects, suture threads or biochemical variables. Others, not directly associated with the surgery technique, are less evaluated, such as the influence of hemorrhagic shock. Objective: Evaluate the effect of hemorrhagic shock in colonic anastomoses in rats, with resistance test to rupture by liquid distension. Methods and Material: Wistar lineage rats, averaging 90 days old and weight varying from 310 to 380 grams were divided into two groups. In the G1 group, 10 animals were submitted to colonic anastomoses in normovolemic terms and the G2 group 10 animals were submitted to colonic anastomoses in hipovolemic conditions. The shock was caused by half milliliter blood withdrawal, done every two minutes, until reached the value of average arterial pressure of 50mmHg or total volume of corresponding withdrawal to 30% of volemia. Serum lactate dosages were carried out at the beginning and at the end of the procedure. The average serum values lactate at the end of the surgery were 1,91 mMol/l in the G1 group and 3,69 mMol/l in the G2 group (p<0,05). On the fifth postoperative day, the animals were submitted to euthanasia. The anastomoses were evaluated with resistance test to rupture by liquid distension. Results: In the G1 group, the average value of colonic rupture was 160,7mmHg whereas in the G2 group was 152,1mmHg (p>0,05). Conclusion: Hemorrhagic shock, in the established conditions of this study, had no influence in colonic anastomosis in rats evaluated with resistance test to rupture by liquid distention
Mestrado
Cirurgia
Mestre em Cirurgia
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Phillips-Moore, Julie. "Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/4983.

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Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the field of psychoneuroimmunology (PNI) has provided evidence to prove the age-old belief that there is a connection between the mind (or mental/emotional states) and the body. Researchers in PNI have now shown that the communication between the nervous and immune systems is bi-directional – i.e. there is a psychological reaction to physical disease and a somatic presentation of psychological disorders - and that the immune system, the autonomic nervous system, the endocrine system and the neuropeptide systems all communicate with each other by means of chemicals called messenger molecules or ligands. This paper outlines research into the treatment of Irritable Bowel Syndrome (IBS) with hypnotherapy, taking into account the mind-body connection and treating both the patient’s physiological and emotional/psychological symptoms rather than treating the physiological symptoms only. In other words, using a more holistic approach to the treatment of IBS. IBS is probably the most common functional gastrointestinal disorder encountered by both gastroenterologists and physicians in primary care. It is estimated that from 10% to 25% of the general population suffer from this condition and that it comprises about 30-50% of the gastroenterologists’ workload, yet the aetiology of IBS is unknown and, so far, there is no cure. Researchers are beginning to view IBS as a multi-faceted disorder in which there appears to be a disturbance in the interaction between the intestines, brain, and autonomic nervous system, resulting in an alteration in the regulation of bowel motility and/or sensory function. Most researchers agree that a subset of IBS sufferers have a visceral hypersensitivity of the gut or, more specifically, an increased perception of sensations in the gut. To date, studies of IBS have proposed previous gastroenteritis, small intestine bacterial overgrowth, psychosocial factors, a genetic contribution, and an imbalance of neurotransmitters as either possible causes or playing a part in the development of IBS. It is generally agreed that a patient’s emotional response to stress can exacerbate the condition. In section 1 of the thesis, the introduction, a detailed description and background appropriate to the study undertaken are provided, including aspects of epidemiology, diagnostic symptom criteria and clinical relevance of the Irritable Bowel Syndrome. Previous studies of various forms of treatment for IBS are discussed with the main emphasis being on treatment with hypnotherapy. All these therapies have concentrated on either mind or body treatments whereas this study demonstrates how hypnotherapy, and the use of imagery, addresses both mind and body. Finally, the rationale for the current study and the specific aims of the thesis are outlined. In section 2, the methodology and assessment instruments used in the clinical trial are discussed, as well as recruitment processes, research plan and timetable, and treatment schedule. Statistical analyses are provided and the main outcomes measures of the clinical trial, its limitations and scientific implications are addressed.
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Phillips-Moore, Julie. "Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome." University of Sydney, 2009. http://hdl.handle.net/2123/4983.

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Doctor of Philosophy
Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the field of psychoneuroimmunology (PNI) has provided evidence to prove the age-old belief that there is a connection between the mind (or mental/emotional states) and the body. Researchers in PNI have now shown that the communication between the nervous and immune systems is bi-directional – i.e. there is a psychological reaction to physical disease and a somatic presentation of psychological disorders - and that the immune system, the autonomic nervous system, the endocrine system and the neuropeptide systems all communicate with each other by means of chemicals called messenger molecules or ligands. This paper outlines research into the treatment of Irritable Bowel Syndrome (IBS) with hypnotherapy, taking into account the mind-body connection and treating both the patient’s physiological and emotional/psychological symptoms rather than treating the physiological symptoms only. In other words, using a more holistic approach to the treatment of IBS. IBS is probably the most common functional gastrointestinal disorder encountered by both gastroenterologists and physicians in primary care. It is estimated that from 10% to 25% of the general population suffer from this condition and that it comprises about 30-50% of the gastroenterologists’ workload, yet the aetiology of IBS is unknown and, so far, there is no cure. Researchers are beginning to view IBS as a multi-faceted disorder in which there appears to be a disturbance in the interaction between the intestines, brain, and autonomic nervous system, resulting in an alteration in the regulation of bowel motility and/or sensory function. Most researchers agree that a subset of IBS sufferers have a visceral hypersensitivity of the gut or, more specifically, an increased perception of sensations in the gut. To date, studies of IBS have proposed previous gastroenteritis, small intestine bacterial overgrowth, psychosocial factors, a genetic contribution, and an imbalance of neurotransmitters as either possible causes or playing a part in the development of IBS. It is generally agreed that a patient’s emotional response to stress can exacerbate the condition. In section 1 of the thesis, the introduction, a detailed description and background appropriate to the study undertaken are provided, including aspects of epidemiology, diagnostic symptom criteria and clinical relevance of the Irritable Bowel Syndrome. Previous studies of various forms of treatment for IBS are discussed with the main emphasis being on treatment with hypnotherapy. All these therapies have concentrated on either mind or body treatments whereas this study demonstrates how hypnotherapy, and the use of imagery, addresses both mind and body. Finally, the rationale for the current study and the specific aims of the thesis are outlined. In section 2, the methodology and assessment instruments used in the clinical trial are discussed, as well as recruitment processes, research plan and timetable, and treatment schedule. Statistical analyses are provided and the main outcomes measures of the clinical trial, its limitations and scientific implications are addressed.
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Pedersen, Katherine Lynn. "Comparison of colorectal cancer screening practices between rural and urban providers." Menomonie, WI : University of Wisconsin--Stout, 2005. http://www.uwstout.edu/lib/thesis/2005/2005pedersenk.pdf.

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Wu, Zhaowen. "Symptoms catastrophizing and symptoms-related social hypervigilance among Chinese patients with irritable bowel syndrome." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38780872.

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Ince, Paul Geoffrey. "Vincristine resistance in the colon." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241381.

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Bordier, Emmanuel. "Fièvre et cancer du colon." Université Claude Bernard Lyon I, 1994. http://www.theses.fr/1994LYO1M172.

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Montbrun, Pierre de. "Les diverticules géants du colon." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25131.

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Books on the topic "Colon"

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Facciorusso, Antonio, and Nicola Muscatiello, eds. Colon Polypectomy. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-59457-6.

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R, Ranganathan S. Colon classification. 6th ed. New Delhi: Ess Ess Publications, 2007.

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R, Ranganathan S. Colon classification. 7th ed. Bangalore: Sarada Ranganathan Endowment for Library Science, 1987.

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Meynet, Denise. L'art colon. Lyon: Fage, 2013.

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Partap, Satija Mohinder. Colon classification: A practical introduction. 7th ed. New Delhi: Ess Ess Publications, 1989.

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Satija, Mohinder Partap. Manual of practical Colon classification. New Delhi: Sterling Publishers, 1989.

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Satija, Mohinder Partap. Manual of practical Colon classification. 4th ed. New Delhi: Concept Book Publishing, 2002.

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Bloc, Paul. Le colon Brossard. Nouméa, New Caledonia?]: Société d'études historiques, 1997.

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Kouraklis, Gregory, and Eugenia (Jenny) Matsiota, eds. Laparoscopic Colon Surgery. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-56728-6.

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Pat, Moyer Mary, and Poste George, eds. Colon cancer cells. San Diego: Academic Press, 1990.

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Book chapters on the topic "Colon"

1

Bredenoord, Albert J., André Smout, and Jan Tack. "Colon." In A Guide to Gastrointestinal Motility Disorders, 75–89. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26938-2_7.

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Naveira, Anaberta Bermúdez, María Mercedes Liñares Paz, Carmen Villalba Martín, and Antonio Luna. "Colon." In Learning Abdominal Imaging, 201–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-88003-5_9.

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Bartram, C. I. "Colon." In Modern Imaging of the Alimentary Tube, 143–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-58971-3_8.

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Jacocks, M. Alex. "Colon." In Oklahoma Notes, 65–70. New York, NY: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4684-0454-8_13.

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Jacocks, M. Alex. "Colon." In Oklahoma Notes, 74–80. New York, NY: Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-2372-6_13.

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Komuro, Terumasa. "Colon." In Atlas of Interstitial Cells of Cajal in the Gastrointestinal Tract, 63–76. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2917-9_5.

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Iovino, F., Y. Lombardo, V. Eterno, P. Cammareri, G. Cocorullo, M. Todaro, and G. Stassi. "Colon." In Human Adult Stem Cells, 143–56. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2269-1_6.

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Romano, Luigia, Ciro Petrella, and Loredana Di Nuzzo. "Colon." In MDCT Anatomy — Body, 135–39. Milano: Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1878-5_20.

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Romano, L., and C. Petrella. "Colon." In Anatomia TC multidetettore — Body, 135–39. Milano: Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1688-0_20.

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Thomusch, Oliver. "Colon." In Essentials of Visceral Surgery, 49–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-66735-4_3.

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Conference papers on the topic "Colon"

1

Babu, Tina, Deepa Gupta, Tripty Singh, and Shahin Hameed. "Colon Cancer Prediction On Different Magnified Colon Biopsy Images." In 2018 Tenth International Conference on Advanced Computing (ICoAC). IEEE, 2018. http://dx.doi.org/10.1109/icoac44903.2018.8939067.

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Jancauskaite, Milda, Alison Campbell, Bruce Jaffray, and Sean Marven. "P48 Shock Colon." In Abstracts of the BSPGHAN Virtual Annual Meeting, 27–29 April 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/flgastro-2021-bspghan.57.

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Ciobanu, Adrian, Mihaela Luca, and Vasile Drug. "Objective Method for Colon Cleansing Evaluation Using Color CIELAB Features." In 2020 International Conference on e-Health and Bioengineering (EHB). IEEE, 2020. http://dx.doi.org/10.1109/ehb50910.2020.9280110.

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Weigt, J., DI Arciniegas, and A. Canbay. "ONLY LINKED COLOR IMAGING INCREASES COLOR CONTRAST BETWEEN COLON POLYPS AND SURROUNDING MUCOSA." In ESGE Days 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1681472.

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Siggens, K., H. Htet, M. Abdelrahim, and P. Bhandari. "Neoplasia Characterisation in IBD Colon: Can a Generic Colon CADx Algorithm Work in Characterising Polyps in an IBD Colon?" In ESGE Days 2023. Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/s-0043-1766020.

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Hong, Wei, Xianfeng Gu, Feng Qiu, Miao Jin, and Arie Kaufman. "Conformal virtual colon flattening." In the 2006 ACM symposium. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1128888.1128901.

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Abad, Carolina, Fátima Valentín, Virginia Matallana, Shanshan Wang, Esther Maderuelo, Ana Pérez, Jiacheng Cao, Eva Santos, and Jose Luis Calleja. "Linfoma primario de colon." In 45 Congreso Nacional de la Sociedad Española de Endoscopia Digestiva. Grupo Pacífico, 2023. http://dx.doi.org/10.48158/seed2023.p346.

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Siggens, Katie, Hein Htet, Hari Suthan, Gaius Longcroft-Wheaton, Mohamed Abdelrahim, and Pradeep Bhandari. "O45 Neoplasia characterisation in IBD colon: can a generic colon CADx algorithm work in characterising polyps in an IBD colon?" In BSG LIVE’23, 19–22 June, ACC Liverpool. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2023. http://dx.doi.org/10.1136/gutjnl-2023-bsg.44.

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Wang, Hsing-Wen, Marcia I. Canto, Joseph Willis, Michael V. Sivak, and Joseph A. Izatt. "Quantitative Laser Scanning Confocal Autofluorescence Microscopy of Normal, Premalignant, and Malignant Colonie Tissues." In Biomedical Optical Spectroscopy and Diagnostics. Washington, D.C.: Optica Publishing Group, 2006. http://dx.doi.org/10.1364/bosd.1996.ft6.

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Abstract:
Laser-induced fluorescence (LIF) spectroscopy has received considerable attention as an application of lasers and fiberoptics to noninvasive tissue diagnosis, particularly in early detection of cancer in the breast1, lung1,2, esophagus3, and colon4-7. LIF spectroscopy is currently under study as a noninvasive method of tissue diagnosis in the colon due to its potential for future routine application in gastrointestinal endoscopy. The distinction of normal colon from premalignant and malignant lesions is of potential clinical importance because the early detection of these lesions is important in the treatment of patients. Previously published analyses of ultraviolet LIF spectral and intensity differences have correctly differentiated adenomas from normal colonic mucosa and hyperplastic polyps with resulting sensitivity, specificity, and PPV of 80-100%, 77-95%, and 82-94%, respectively4-7. Although these initial studies have provided compelling evidence supporting the use of LIF spectroscopy in early colon cancer diagnosis, there remains little information available regarding the specific origins and biochemical correlates of LIF spectra in colonic tissue. Proposed theories for the source of LIF differences in the colonic polyp model have included changes in gross polyp morphology7, microvascular changes7, differences in crypt architecture8, and biochemical differences characteristic of dysplastic epithelial cells8.
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Norris, James A., Michael D. Barton, Brynmor J. Davis, Jerry Bieszczad, Norm L. Meunier, Nathan W. Brown, and David B. Kynor. "Anatomically correct deformable colon phantom." In SPIE Medical Imaging, edited by Kenneth H. Wong and David R. Holmes III. SPIE, 2011. http://dx.doi.org/10.1117/12.878173.

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Reports on the topic "Colon"

1

Buchsbaum, Donald J., and Daniel A. Vallera. Radioimmunotoxin Therapy of Experimental Colon and Ovarian Cancer. Office of Scientific and Technical Information (OSTI), February 2006. http://dx.doi.org/10.2172/875907.

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Lico, Matilde, Giancarlo Gismondo Velardi, Rachele Lazzeroni, Angela Teti, Ilaria V. Trecroci, Rosario Maccarone, Letterio Militano, et al. Acute Appendicitis with Retroperitoneal Ectopic Location from Ascending Colon. Science Repository, April 2024. http://dx.doi.org/10.31487/j.jscr.2024.01.04.

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Anatomical variant of appendix are very rare, but is important to detect variations of localization for an immediate and correct diagnosis, avoiding complications. Such occurrences can mimic other pathologies and ultrasound examination often does not allow to obtain a precise diagnosis. In this case report, Computed Tomography allowed us to diagnose an inflamed appendix originating from the ascending colon, allowing timely and targeted surgery.
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zhang, yijia, and Li xU. Meta-analysis of spontaneous colon rupture among Chinese population. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0046.

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Eckhardt, S. G., Aik C. Tan, Todd M. Pitts, and Betty Diamond. Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada569435.

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Tan, Aik C., S. G. Eckhardt, Todd M. Pitts, and Betty Diamond. Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada569509.

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Eckhardt, S. G., Aik C. Tan, and Todd M. Pitts. Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada599229.

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Tan, Aik C., S. G. Eckhardt, and Todd M. Pitts. Collaborative Model for Acceleration of Individualized Therapy of Colon Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada615427.

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Rafie, Carlin, and Kristi Seay. Beware Millenials! Colon Cancer is on the rise in your generation. Blacksburg, VA: Virginia Cooperative Extension, January 2021. http://dx.doi.org/10.21061/hnfe-918.

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N Chui, Juanita, William A Ziaziaris, Ali Mohtashami, Christopher SH Lim, Nazim Bhimani, and Thomas J Hugh. Biliary Metastases from Colon Cancer: A Rare Differential Diagnosis for Obstructive Jaundice. Science Repository, December 2022. http://dx.doi.org/10.31487/j.ajscr.2022.03.03.

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Metastatic infiltration of the biliary tree is a rare manifestation of colorectal cancer. Currently, there is limited evidence to inform the management of such cases and the prognosis is poor. Herein, we report a case of biliary colorectal metastases with extensive multifocal involvement and discuss the challenges of the diagnosis and treatment.
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Dor, Avi, Partha Deb, Michael Grossman, Gregory Cooper, Siran Koroukian, and Fang Xu. Impact of Mortality-Based Performance Measures on Hospital Pricing: the Case of Colon Cancer Surgeries. Cambridge, MA: National Bureau of Economic Research, September 2013. http://dx.doi.org/10.3386/w19447.

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