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Journal articles on the topic 'Collage SAB'

Author: Grafiati

Published: 19 October 2024

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1

Sharmila S, Arockia, Abhishek Srivastava, and Sachin Onkar Khairnar. "Salinity tolerance and survival of an Indian major carp, Cirrhinus mrigala (mrigal): Feasibility assessment for rearing in inland saline water." Ecology, Environment and Conservation 29, no. 01 (2023): 204–12. http://dx.doi.org/10.53550/eec.2023.v29i01.034.

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An experimental trial was conducted in triplicate to determine the effect of different salinity levels 0 (SA0), 2(SA2), 4(SA4), 6(SA6), 8(SA8) and 10 (SA10) ppt on survival, behaviour, and morphological changes in mrigal, Cirrhinus mrigala fingerlings during short-term rearing in inland saline water in glass aquaria for 10 days. Healthy fingerlings (average length-11.18 cm, average weight-11.05 g) of mrigal, procured from the Instructional cum Research Farm, College of Fisheries, were conditioned for one week at 0 ppt (freshwater) in FRP pools and conditioned fingerlings were gradually acclimated to varying salinities by raising the salinity by 1 ppt hourly and then stocked into glass aquaria of respective salinity levels @ 10 fingerlings aquarium-1. Predetermined salinity levels and the water level were maintained in all the treatments and fish were fed with pelleted feed (crude protein 26.12%) @ 0.5% of fish body weight, once a day, as sustenance ration throughout the experimental period. The results indicated that all the water quality parameters, except temperature, varied significantly (P0.05) across treatments. Furthermore, no fish mortality occurred up to 6 ppt salinity during the experiment. In contrast, survival rates were 93.33% and 86.67% at 8 and 10 ppt salinity, respectively at the termination of the experiment. Normal swimming and feeding (feed intake) behaviour were recorded up to 6 ppt, whereas no adverse morphological changes were observed in fish during the tolerance test in all the treatments. From the above results, it can be concluded that mrigal, C. mrigala can tolerate salinity up to 6 ppt during short term (10 days) rearing in inland saline water.

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Sekiguchi, Hiroyuki, Kentaro Uchida, Osamu Matsushita, Gen Inoue, Nozomu Nishi, Ryo Masuda, Nana Hamamoto, Takaki Koide, Shintaro Shoji, and Masashi Takaso. "Basic Fibroblast Growth Factor Fused with Tandem Collagen-Binding Domains from Clostridium histolyticum Collagenase ColG Increases Bone Formation." BioMed Research International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8393194.

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Basic fibroblast growth factor 2 (bFGF) accelerates bone formation during fracture healing. Because the efficacy of bFGF decreases rapidly following its diffusion from fracture sites, however, repeated dosing is required to ensure a sustained therapeutic effect. We previously developed a fusion protein comprising bFGF, a polycystic kidney disease domain (PKD; s2b), and collagen-binding domain (CBD; s3) sourced from the Clostridium histolyticum class II collagenase, ColH, and reported that the combination of this fusion protein with a collagen-like peptide, poly(Pro-Hyp-Gly)10, induced mesenchymal cell proliferation and callus formation at fracture sites. In addition, C. histolyticum produces class I collagenase (ColG) with tandem CBDs (s3a and s3b) at the C-terminus. We therefore hypothesized that a bFGF fusion protein containing ColG-derived tandem CBDs (s3a and s3b) would show enhanced collagen-binding activity, leading to improved bone formation. Here, we examined the binding affinity of four collagen anchors derived from the two clostridial collagenases to H-Gly-Pro-Arg-Gly-(Pro-Hyp-Gly)12-NH2, a collagenous peptide, by surface plasmon resonance and found that tandem CBDs (s3a-s3b) have the highest affinity for the collagenous peptide. We also constructed four fusion proteins consisting of bFGF and s3 (bFGF-s3), s2b-s3b (bFGF-s2b-s3), s3b (bFGF-s3b), and s3a-s3b (bFGF-s3a-s3b) and compared their biological activities to those of a previous fusion construct (bFGF-s2b-s3) using a cell proliferation assay in vitro and a mouse femoral fracture model in vivo. Among these CB-bFGFs, bFGF-s3a-s3b showed the highest capacity to induce mesenchymal cell proliferation and callus formation in the mice fracture model. The poly(Pro-Hyp-Gly)10/bFGF-s3a-s3b construct may therefore have the potential to promote bone formation in clinical settings.

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Figueiredo, Amanda Menezes, Ana Carolina Cardoso, Bruna Leticia Buzati Pereira, Renata Aparecida Candido Silva, Andrea Freitas Goncalves Della Ripa, Tatiana Fernanda Bachiega Pinelli, Bruna Camargo Oliveira, et al. "Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways." PLOS ONE 17, no. 3 (March 4, 2022): e0264854. http://dx.doi.org/10.1371/journal.pone.0264854.

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Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Açai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of açai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% açai pulp (SA2, n = 12) and fed standard chow with 5% açai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% açai pulp (IA2, n = 12), and fed standard chow with 5% açai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Açai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P<0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P<0.001; dose-dependent effect). In conclusion, açai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of açai pulp supplementation have dose-dependent effects on cardiac remodeling.

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Bonnet, N., N. Laroche, H. Beaupied, L. Vico, E. Dolleans, C. L. Benhamou, and D. Courteix. "Doping dose of salbutamol and exercise training: impact on the skeleton of ovariectomized rats." Journal of Applied Physiology 103, no. 2 (August 2007): 524–33. http://dx.doi.org/10.1152/japplphysiol.01319.2006.

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Previous studies in healthy rats have demonstrated a deleterious bone impact of β-agonist treatment. The purpose of this study was to examine the trabecular and cortical effects of β2-agonists at doping dose on treadmill exercising rats with estrogen deficiency. Adult female rats were ovariectomized (OVX; n = 44) or sham operated ( n = 12). Then, OVX rats received a subcutaneous injection of salbutamol (SAB) or vehicle with (EXE) or without treadmill exercise for 10 wk. Bone mineral density (BMD) was analyzed by densitometry. Microcomputed tomography and histomorphometric analysis were performed to study trabecular bone structure and bone cell activities. After 10 wk, SAB rats presented a much more marked decrease of BMD and trabecular parameters. Exercise did not change the high level of bone resorption in OVX EXE SAB compared with OVX SAB group (both on COOH-terminal collagen cross-links and osteoclast number). These results confirm the deleterious effect of β2-agonists on bone quantity (femoral BMD gain: OVX EXE, +6.8%, vs. OVX EXE SAB, −1.8%; P < 0.01) and quality (−8.0% of femoral trabecular thickness in OVX EXE SAB vs. OVX EXE), indicating that SAB suppresses the effect of EXE in OVX rats. Furthermore, we notice that the slight beneficial effect of exercise was mainly localized in the tibia. These findings indicate the presence of a bone alteration threshold below which there is no more alteration in structural bone quantity and quality. The negative effects of SAB on bone observed in this study in trained rats may indicate potential complications in doping female athletes with exercise-induced amenorrhea.

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Zhou, Guoying, Jiayan Zhu, Liang Jin, Jing Chen, Ruojiao Xu, Yali Zhao, Tingzi Yan, and Haitong Wan. "Salvianolic-Acid-B-Loaded HA Self-Healing Hydrogel Promotes Diabetic Wound Healing through Promotion of Anti-Inflammation and Angiogenesis." International Journal of Molecular Sciences 24, no. 7 (April 6, 2023): 6844. http://dx.doi.org/10.3390/ijms24076844.

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Inflammatory dysfunction and angiogenesis inhibition are two main factors leading to the delayed healing of diabetic wounds. Hydrogels with anti-inflammatory and angiogenesis-promoting effects have been considered as promising wound care materials. Herein, a salvianolic acid B (SAB)-loaded hyaluronic acid (HA) self-healing hydrogel (HA/SAB) with anti-inflammatory and pro-angiogenesis capacities for diabetic wound healing is reported. The HA hydrogel was prepared via the covalent cross-linking of aldehyde groups in oxidized HA (OHA) and hydrazide groups in adipic dihydrazide (ADH)-modified HA (HA-ADH) with the formation of reversible acylhydrazone bonds. The obtained HA hydrogel exhibited multiple favorable properties such as porous structures, excellent self-healing properties, a sustainable release capacity of SAB, as well as excellent cytocompatibility. In addition, the effects of the SAB-loaded HA self-healing hydrogel were investigated via a full-thickness skin defect model using diabetic rats. The HA/SAB hydrogel showed enhanced skin regeneration effects with accelerated wound closure, shorter remaining dermal space length, thicker granulation tissue formation, and more collagen deposition. Furthermore, reduced inflammatory response and enhanced vascularization were found with HA/SAB2.5 hydrogel-treated wounds, indicating that the hydrogel promotes diabetic wound healing through the promotion of anti-inflammation and angiogenesis. Our results suggest that the fabricated SAB-loaded HA self-healing hydrogel is promising as a wound dressing for the treatment of diabetic wounds.

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Bauer, Ryan, Katarzyna Janowska, Kelly Taylor, Brad Jordan, Steve Gann, Tomasz Janowski, Ethan C. Latimer, Osamu Matsushita, and Joshua Sakon. "Structures of three polycystic kidney disease-like domains fromClostridium histolyticumcollagenases ColG and ColH." Acta Crystallographica Section D Biological Crystallography 71, no. 3 (February 26, 2015): 565–77. http://dx.doi.org/10.1107/s1399004714027722.

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Clostridium histolyticumcollagenases ColG and ColH are segmental enzymes that are thought to be activated by Ca2+-triggered domain reorientation to cause extensive tissue destruction. The collagenases consist of a collagenase module (s1), a variable number of polycystic kidney disease-like (PKD-like) domains (s2a and s2b in ColH and s2 in ColG) and a variable number of collagen-binding domains (s3 in ColH and s3a and s3b in ColG). The X-ray crystal structures of Ca2+-bound holo s2b (1.4 Å resolution,R= 15.0%,Rfree= 19.1%) and holo s2a (1.9 Å resolution,R= 16.3%,Rfree= 20.7%), as well as of Ca2+-free apo s2a (1.8 Å resolution,R= 20.7%,Rfree= 27.2%) and two new forms of N-terminally truncated apo s2 (1.4 Å resolution,R= 16.9%,Rfree= 21.2%; 1.6 Å resolution,R= 16.2%,Rfree= 19.2%), are reported. The structurally similar PKD-like domains resemble the V-set Ig fold. In addition to a conserved β-bulge, the PKD-like domains feature a second bulge that also changes the allegiance of the subsequent β-strand. This β-bulge and the genesis of a Ca2+pocket in the archaeal PKD-like domain suggest a close kinship between bacterial and archaeal PKD-like domains. Different surface properties and indications of different dynamics suggest unique roles for the PKD-like domains in ColG and in ColH. Surface aromatic residues found on ColH s2a-s2b, but not on ColG s2, may provide the weak interaction in the biphasic collagen-binding mode previously found in s2b-s3.B-factor analyses suggest that in the presence of Ca2+the midsection of s2 becomes more flexible but the midsections of s2a and s2b stay rigid. The different surface properties and dynamics of the domains suggest that the PKD-like domains of M9B bacterial collagenase can be grouped into either a ColG subset or a ColH subset. The conserved properties of PKD-like domains in ColG and in ColH include Ca2+binding. Conserved residues not only interact with Ca2+, but also position the Ca2+-interacting water molecule. Ca2+aligns the N-terminal linker approximately parallel to the major axis of the domain. Ca2+binding also increases stability against heat and guanidine hydrochloride, and may improve the longevity in the extracellular matrix. The results of this study will further assist in developing collagen-targeting vehicles for various signal molecules.

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Nabi Khan, Md Rashidoon, Mostafa Taufiq Ahmed, and Mesbah Uddin Ahmed. "Lumbar Interverterbral Disc Prolapse (PLID) Surgery under SAB." Bangladesh Journal of Neurosurgery 11, no. 2 (September 7, 2022): 75–79. http://dx.doi.org/10.3329/bjns.v11i2.61449.

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Background: The type of surgery performed on the spine encompasses operations for trauma, deformity, and myelopathy. The complexity of procedures is continuing to increase and older patients with significant co-morbidities are being offered ever more major procedures for which they would have previously not been considered. Developing areas include surgery for degenerative scoliosis and an increase in operations performed on the anterior lumbar spine Spinal anaesthesia for Lumbar Interverterbral Disc Prolapse (PLID) surgery is becoming increasingly more popular because this anaesthetic technique allows the patient to comfortable self-position and avoid neurological injury that may occur with prone positioning under general anaesthesia. PLID surgery is also a comparatively cost effective surgical procedure. Aim of the study: The aim of the study was to observe the extent of surgical options as per pathological outcome in terms of postoperative pain, immediate functional recovery and patient’s satisfaction for undergoing PLID surgery under spinal anaesthesia. Methods: This observation study was conducted in the department of Neuro surgery Sylhet MAG Osmani Medical College Hospital in association with Central Hospital Limited Sylhet from January 2007 to July 2019. A total of 4000 healthy cooperative patients with ASA I-III grading, undergoing Lumbar Interverterbral Disc Prolapse (PLID) surgery at single level to two levels also recurrent cases operative maximum twice previously were selected as study population. A comprehensive perioperative was carried out documenting per operative events anaesthetic complications, pace of physiological and functional recovery and patient’s satisfaction. Variables were recorded as pain level using a visual analogue scale (VAS) at 1, 6, 12 & 24 hours; patients level of satisfaction during the stay on the ward using verbal rating scale (VER); during of surgery; per amount of blood loss. Data were analyzed by SPSS version 19.0. Results: Among 4000 participants, man was 2416(60.4%) and female 1684 (39.6%). In incidence of PLID surgery 36-45 years age group was almost fifty percent 49.42%. In level of PLID L3/4 was highest 39.0%. Regarding of per operative blood, new was 3337(84.18%) & mean value was 47.65(±9.14) and recurrent 633(15.82%) & mean value was 55.60(±13.80). In duration of surgery the mean of new was 22.51(±3.67)& recurrent 26.72(±5.78). Regarding per operative complications, hypertension was highest 1440(36.0%) followed by hypotension 992(24.4%) & nausea/vomiting 960(24.0%).Average hospital stay was 36 to 48 hours. Conclusion:As our results correspond to the others available studies it is clear that, spinal anaethesia can be definitely used for doing at least 2 levels of PLID surgery as it is also more cost effective and patient need to stay minimum in time duration. Bang. J Neurosurgery 2022; 11(2): 75-79

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Al-Douri, Ehsan, and Ahmed Hasan. "Effect of Magnesium and Foliar Spray of Gibberellic and Salicylic Acids on Vegetative Growth Characteristics of Peach (Prunus persica L.) Saplings CV. Miski." Tikrit Journal for Agricultural Sciences 19, no. 2 (January 18, 2023): 19–30. http://dx.doi.org/10.25130/tjas.19.2.3.

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This study was conducted in the lath house of the Department of Horticulture and Landscape Design/ College of Agriculture/ Tikrit University during the growing season of 2017 to investigate the effect of magnesium application and the foliar spraying of both gibberellic and salicylic acids on the vegetative growth characteristics of peach saplings CV. Miski, aged one year which were grafted on Apricot seedlings. Magnesium was added in three concentrations (0, 50 and 100 mg.litre-1) and was labelled as Mg0, Mg1 and Mg2 consecutively. The gibberellic acid was sprayed in three concentrations (0, 50 and 100 mg.liter-1) and labelled as GA0,GA1 and GA2 consecutively. Besides the salicylic acid was sprayed with the following concentrations (0, 100 and 200 mg.L-1) and labelled as SA0, SA1 and SA2 consecutively. All these processes were performed starting from April 10 three times, with a time interval of three weeks. The experiment was performed based on the split-plot system in Randomized Complete Block Design (RCBD) in which the various magnesium concentrations were added to the main plots and both the gibberellic and salicylic acids were applied to the subplots. The results showed that the addition of magnesium has positively increased the main stem diameter, single leaf area, total leaves area per plant and the relative chlorophyll concentrations in leaves. The height and the diameter of a sapling, length of the branches, leaf area and total leaves area of sapling were increased as a result of foliar spraying with gibberellic acid. The spraying of salicylic acid has a positive effect on the saplings’ characteristics (leaf area, total leaves area and relative chlorophyll concentration in leaves). The dual or triple interaction treatments between the three studied factors had the positive results in most characteristics were investigated.

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Suh, Minhee. "The association of salivary alpha-amylase, heart rate variability, and psychological stress on objectively measured sleep behaviors among college students." Frontiers of Nursing 9, no. 1 (March 1, 2022): 63–70. http://dx.doi.org/10.2478/fon-2022-0008.

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Abstract Objective This study aimed to evaluate sleep behaviors among college students, to assess salivary alpha-amylase (sAA) and heart rate variability (HRV) in association with stress, and to investigate sleep-related factors including sAA, HRV, and stress among them. Methods Saliva samples for sAA assessment and HRV measurements in the supine position were taken between 3 PM and 6 PM. The level of prolonged psychological stress for the previous week was evaluated using the Korean version of the Global Assessment of Recent Stress (GARS-K), and sleep behaviors were assessed using an actigraphy device. Results A total of 86 healthy college students participated in this study. Sleep behaviors of the college students were not good, with 84% sleep efficiency (SE) and 62.7 min wake after sleep onset (WASO). The average sAA level was 65.8 U/mL in the participants. Although neither the sAA level nor HRV indices were significantly correlated with prolonged psychological stress, decreased normalized high frequency (nHF) on HRV was independently associated with a higher level of stress when adjusted for age and sex. Higher stress (r = −0.276, P = 0.011) and lower sAA (r = 0.266, P = 0.030) had significant correlations with shorter time in bed; however, it was sAA that was independently associated with time in bed (β = 0.244, p = 0.044). Decreased nHF (β = 0.245, P = 0.027) and higher body mass index (BMI) (β = −0.224, P = 0.043) were independently related to and poorer SE. Conclusions Poor sleep behaviors were associated with decreased parasympathetic activity, a physiological change to psychological stress, rather than with psychological stress itself among college students. Thus, sAA and HRV should be considered as significant factors for impaired sleep behaviors in relation to psychological stress.

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Lee, Kyung Sook. "Intellectuals in Colonial Mission College: A Study on Soongsil College Professors." Society and History 136 (December 31, 2022): 153–86. http://dx.doi.org/10.37743/sah.136.6.

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Sweetser, Michelle, Tamar Chute, Elizabeth James, Jane LaBarbara, and Krista Oldham. "College and University Archivists: Doing It All for Less." American Archivist 86, no. 1 (March 1, 2023): 141–206. http://dx.doi.org/10.17723/2327-9702-86.1.141.

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ABSTRACT The Society of American Archivists (SAA) and its members have conducted numerous surveys of the archival profession—both of archivists as individuals and of archival institutions—through the years. In 1949, the College and University Archives Committee of SAA conducted the first survey specifically of college and university archives. Building off previous surveys, in 2021 the College and University Archives Landscape Survey was undertaken by the College and University Archives Section to gather data about the management and organization of college and university archives within the United States, as well as about the backgrounds, skills, responsibilities, and tasks in which college and university archivists are engaged. While the initial results were released to the membership, this article represents further analysis and contextualization with other professional literature. It identifies trends, similarities, and differences between surveys and eras, and it provides suggestions for future surveys and research.

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Yuanyuan, Zhou, Li Song, Yu Shuchun, Dong Boyu, Xu Zhitao, and Li Liming. "A Comprehensive Study on the Rheological Properties of Collagen/PVA Spinning Solutions from Acetic Acid Solvent." Science of Advanced Materials 13, no. 12 (December 1, 2021): 2384–92. http://dx.doi.org/10.1166/sam.2021.4155.

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Collagen and polyvinylalcohol (PVA) are extremely important in the applications of biomaterials including with electrospinning and wet-spinning methods. However, the rheological behavior of collagen and PVA blended solutions before spinning is still scarce. In this work, collagen was firstly extracted from pigskin building on the maximum maintenance of the natural structure and blended with PVA. The following detailed investigation on the viscosity and the rheology of blended solutions were carried out by rotate rheometer. The obtained results suggested that collagen/PVA solutions performed as Non-Newtonian fluids. Significantly, all the samples showed the shear thinning pseudoplastic behaviors with the steady shear rate. With increasing the collagen content or decreasing the operating temperature, the viscosity of blended solutions both increased at the same shear rate of 16.8 s−1, accompanied by the fall of the Non-Newtonian index (n) for the collagen/PVA samples. Furthermore, both low temperature and high concentration increased the structure of the spinning solution, which indicated that the temperature should be controlled in a higher range to improve the spinnability of the solution, but without collagen decomposition in the whole process. The increase of PVA content could reduce the degree of system structure, that was to say that the addition of PVA improved the spinnability of the system. As an application, the solution of collagen/PVA was wet spinned with the ethanol absolute as coagulant and collagen/PVA composite fibers were successfully prepared, which have compensated for the disadvantage of mono-component collagen materials. Of course, this experimental results is not limited to the above application, which really extends the potential use of collagen/PVA blended solutions towards the design of the collagenbased biomaterials.

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Chew, Chin Hin. "5th College of Physicians Lecture – A Physician’s Odyssey: Recollections and Reflections*." Annals of the Academy of Medicine, Singapore 37, no. 11 (November 15, 2008): 968–76. http://dx.doi.org/10.47102/annals-acadmedsg.v37n11p968.

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Some reminiscences of events since the 1930s are presented chronologically. These include sketches of informal introduction to Medicine at the General Hospital (SGH), the amazing spirit of medical professionals during the “Syonan” years at Tan Tock Seng Hospital (TTSH) and of professors of Medicine and training in Hong Kong, Singapore and Britain. An account of practice of Medicine in the Civil Service, of teaching and research and of evolution of specialist training and examinations in the Academy of Medicine, the University’s Post Graduate School (DGMS) and Specialist Accreditation Board (SAB) is given. The over-riding values of our profession are stressed, always contributing to improving the quality and standards of practice in the interests of our patients and fellowmen. Key words: Calling, Doctor, Ethics, Medical student, Medicine, Patient, Research, TB control

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Lawal, Amina Tijani, Olufemi Adeola Balogun, Kemi Abiodun Soyinka, and Bamidele Emeka Nwosu. "Symbols of Resistance and Transformation in Nigerian Collage Art." Studies in Art and Architecture 3, no. 3 (September 2024): 8–11. http://dx.doi.org/10.56397/saa.2024.09.02.

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This paper explores the dynamic role of collage art in Nigerian cultural and political discourse, focusing on how artists employ various symbols and motifs to navigate and critique post-colonial themes. By analyzing artworks that integrate both traditional and contemporary materials, the study highlights how these pieces reflect and influence perceptions of cultural identity, resistance, transformation, and societal progress. Through detailed examinations of specific artworks, the paper demonstrates how Nigerian collage artists articulate issues of colonial legacy, identity reaffirmation, and socio-political challenges. Furthermore, it discusses the broader cultural impact of these artworks, showing how they foster public dialogue and inspire community actions that address ongoing post-colonial challenges. This study underscores the power of visual art as a medium for social reflection and change, contributing significantly to both academic and cultural discussions about post-colonialism in Nigeria.

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Bauer, Ryan, Jeffrey J. Wilson, Sagaya Theresa Leena Philominathan, Dan Davis, Osamu Matsushita, and Joshua Sakon. "Structural Comparison of ColH and ColG Collagen-Binding Domains from Clostridium histolyticum." Journal of Bacteriology 195, no. 2 (November 9, 2012): 318–27. http://dx.doi.org/10.1128/jb.00010-12.

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ABSTRACTClostridium histolyticumsecretes collagenases, ColG and ColH, that cause extensive tissue destruction in myonecrosis. The C-terminal collagen-binding domain (CBD) of collagenase is required for insoluble collagen fibril binding and subsequent collagenolysis. The high-resolution crystal structures of ColG-CBD (s3b) and ColH-CBD (s3) are reported in this paper. The new X-ray structure of s3 was solved at 2.0-Å resolution (R= 17.4%;Rfree= 23.3%), while the resolution of the previously determined s3b was extended to 1.4 Å (R= 17.9%;Rfree= 21.0%). Despite sharing only 30% sequence identity, the molecules resemble one another closely (root mean square deviation [RMSD] Cα= 1.5 Å). All but one residue, whose side chain chelates with Ca2+, are conserved. The dual Ca2+binding site in s3 is completed by an unconserved aspartate. Differential scanning calorimetric measurements showed that s3 gains thermal stability, comparable to s3b, by binding to Ca2+(holoTm= 94.1°C;apoTm= 70.2°C).holos3 is also stabilized against chemical denaturants urea and guanidine HCl. The three most critical residues for collagen interaction in s3b are conserved in s3. The general shape of the binding pocket is retained by altered loop structures and side chain positions. Small-angle X-ray scattering data revealed that s3 also binds asymmetrically to minicollagen. Besides the calcium-binding sites and the collagen-binding pocket, architecturally important hydrophobic residues and the hydrogen-bonding network around thecis-peptide bond are well conserved within the metallopeptidase subfamily M9B. CBDs were previously shown to bind to the extracellular matrix of various tissues. Compactness and extreme stability in physiological Ca2+concentration possibly make both CBDs suitable for targeted growth factor delivery.

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McCarthy, Claudine. "Learn how CSAOs become college presidents." Student Affairs Today 18, no. 3 (May 21, 2015): 6. http://dx.doi.org/10.1002/say.30072.

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DeStasio, Joyce. "Review of Empathy by Design: Empathy-Driven Marketing for Libraries." Journal of New Librarianship 9, no. 2 (August 7, 2024): 59–62. http://dx.doi.org/10.33011/newlibs/17/6.

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Lyerly, Eric. "Did court dismiss Title IX erroneous outcome claim?" Student Affairs Today 26, no. 7 (September 21, 2023): 8. http://dx.doi.org/10.1002/say.31297.

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John Doe was a Stonehill College football player. While at the college, John Doe developed a friendship with a female student, Jane Roe. On three separate occasions, John Doe and Jane Roe engaged in consensual sexual contact.

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Thomson, George. "A Discoid Marker Stone from Collace, Perthshire." Scottish Archaeological Journal 31, no. 1-2 (October 2009): 107–14. http://dx.doi.org/10.3366/saj.2010.0006.

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A small discoid stone fragment from the churchyard at Collace, Perthshire (now missing) is described. It is suggested that this is likely to be the disc head of a medieval marker stone. As the length of the shaft is unknown, it is impossible to tell whether it is the head from a churchyard cross or a gravemarker. The artefact is unusual in having complex decoration more akin to that found on medieval Basque gravemarkers and isolated examples from England and Ireland. Although there is a possible alternative interpretation of the design on the verso, as a flower, it is suggested that the design on both faces represents the Seal of Solomon. This is possibly the earliest use of this symbol in Scotland.

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Gelpi, Aileen. "Did college radio station violate coach's contract?" Student Affairs Today 22, no. 1 (March 15, 2019): 8. http://dx.doi.org/10.1002/say.30594.

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Lyerly, Eric. "Did court stop college from enforcing suspension?" Student Affairs Today 23, no. 7 (September 16, 2020): 8. http://dx.doi.org/10.1002/say.30801.

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McCarthy, Claudine. "Student affairs career led to college presidency." Student Affairs Today 26, no. 10 (December 21, 2023): 12. http://dx.doi.org/10.1002/say.31339.

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When Donna Brown applied for a fellowship as a student affairs professional working toward her doctorate degree, the application process required her to come up with a “lofty long‐term goal.” Acknowledging her start as a student at a tribal college, she thought, “my life would come full circle if I ever became a president of a tribal college,” she now recalls. “At that time, I don’t know if I believed it, but I wrote that as my long‐term goal,” she added.

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Tian, Ye, Qing-Hui Zeng, Lin Shi, and Zhi-Feng Xian. "Type I Collagen Adsorption Behavior on the Control and Modified Surface of Polylactide Coating." Science of Advanced Materials 14, no. 7 (July 1, 2022): 1190–95. http://dx.doi.org/10.1166/sam.2022.4322.

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Knowledge of the bio-macromolecules adsorption on polylactide (PLA) was essential to the application of PLA-based biomedical materials. This study presented the adsorption behavior of type I collagen on control (CH3-enriched) and modified (introduced COOH– and CONH2– respectively) PLA surfaces by quartz crystal microbalance with energy dissipation measurements (QCM-D) and atomic force microscopy (AFM). The results showed that the Langmuir adsorption isotherms were obtained, indicating a monomolecular layer adsorption of collagen on PLA coatings. Adsorption of collagen could reach equilibrium more quickly on the modified surfaces than on the control. Large amounts of collagen (1522.2 ng·cm−2) was assembled tightly on the COOH-enriched surface of PLA, owing to the electrostatic attracting. However it was inhibited on the CONH2-enriched surface because of its increasing hydrophilicity. A netlike structure was formed on the control and COOH-enriched surfaces, while only a few of braching fibril was found on the CONH2-enriched surface. The behaviour of protein adsorption on the surfaces with different groups might effect the next stage of cell adhesion on scaffold.

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McCarthy, Claudine. "Consider diverse perspectives for improving affordability of on‐campus student housing." Student Affairs Today 27, no. 6 (August 23, 2024): 3–11. http://dx.doi.org/10.1002/say.31441.

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PHILADELPHIA — Housing affordability, or lack thereof, is increasingly impacting college students’ ability to succeed and complete their degree, according to Ryan Jensen, AICP, Project Manager with Brailsford & Dunlavey, a program management firm. He spoke on a panel of student housing experts with diverse perspectives at the Society for College and University Planning's annual conference.

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Gao, Antony, Kangzhe Xie, Sameesh Gupta, Gulfam Ahmad, and Paul K. Witting. "Cyclic Nitroxide 4-Methoxy-Tempo May Decrease Serum Amyloid A-Mediated Renal Fibrosis and Reorganise Collagen Networks in Aortic Plaque." International Journal of Molecular Sciences 25, no. 14 (July 18, 2024): 7863. http://dx.doi.org/10.3390/ijms25147863.

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Acute-phase serum amyloid A (SAA) can disrupt vascular homeostasis and is elevated in subjects with diabetes, cardiovascular disease, and rheumatoid arthritis. Cyclic nitroxides (e.g., Tempo) are a class of piperidines that inhibit oxidative stress and inflammation. This study examined whether 4-methoxy-Tempo (4-MetT) inhibits SAA-mediated vascular and renal dysfunction. Acetylcholine-mediated vascular relaxation and aortic guanosine-3′,5′-cyclic monophosphate (cGMP) levels both diminished in the presence of SAA. 4-MetT dose-dependently restored vascular function with corresponding increases in cGMP. Next, male ApoE-deficient mice were administered a vehicle (control, 100 µL PBS) or recombinant SAA (100 µL, 120 µg/mL) ± 4-MetT (at 15 mg/kg body weight via i.p. injection) with the nitroxide administered before (prophylaxis) or after (therapeutic) SAA. Kidney and hearts were harvested at 4 or 16 weeks post SAA administration. Renal inflammation increased 4 weeks after SAA treatment, as judged by the upregulation of IFN-γ and concomitant increases in iNOS, p38MAPK, and matrix metalloproteinase (MMP) activities and increased renal fibrosis (Picrosirius red staining) in the same kidneys. Aortic root lesions assessed at 16 weeks revealed that SAA enhanced lesion size (vs. control; p < 0.05), with plaque presenting with a diffuse fibrous cap (compared to the corresponding aortic root from control and 4-MetT groups). The extent of renal dysfunction and aortic lesion size was largely unchanged in 4-MetT-supplemented mice, although renal fibrosis diminished at 16 weeks, and aortic lesions presented with redistributed collagen networks. These outcomes indicate that SAA stimulates renal dysfunction through promoting the IFN-γ–iNOS–p38MAPK axis, manifesting as renal damage and enhanced atherosclerotic lesions, while supplementation with 4-MetT only affected some of these pathological changes.

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D’Orio, Wayne. "VP focuses on creating a better enrollment process." Student Affairs Today 27, no. 3 (May 19, 2024): 12. http://dx.doi.org/10.1002/say.31405.

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When Chrissy Davis Jones, Ed.D., MSW, joined Pennsylvania's Harrisburg Area Community College in April 2021, it was hard to be optimistic about college enrollment. A year into the pandemic, colleges across the country were losing students. And many were already bemoaning the upcoming enrollment cliff that will shrink the number of available students starting in 2025.

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Behera, Tapas Ranjan. "Clinical Profile of Dengue Fever at SCB Medical College and Hospital, Cuttack, Odisha." Journal of Communicable Diseases 50, no. 04 (December 31, 2018): 1–6. http://dx.doi.org/10.24321/0019.5138.201822.

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Lyerly, Eric. "Consider implications of Supreme Court decision on affirmative action in admissions." Student Affairs Today 26, no. 6 (August 17, 2023): 3–7. http://dx.doi.org/10.1002/say.31280.

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In a decision that reverberated through the halls of higher education, the U.S. Supreme Court struck down race‐conscious admissions programs at Harvard University and the University of North Carolina (See Students for Fair Admissions, Inc. v. President and Fellows of Harvard College, Slip Op. No. 20‐1199 (2023)). The decision overturns decades of precedent and effectively invalidates affirmative action policies in college admissions.

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Chan, Queenie Monica. "Reconstructing images of history: Christopher Doyle, Rabbit-Proof Fence and postcolonial collage." Studies in Australasian Cinema 2, no. 2 (January 2008): 121–40. http://dx.doi.org/10.1386/sac.2.2.121_1.

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Sutton, Halley. "Virtual reality testing of emergency scenarios could improve student reactions in the future." Student Affairs Today 27, no. 4 (June 13, 2024): 4. http://dx.doi.org/10.1002/say.31415.

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Artificial intelligence is infiltrating every sector of college life, from admissions papers to now, research on how virtual reality simulations can improve campus safety. Emergency Management Science and Technology published a paper titled “Experimental Research on College Students’ Emergency Ability and Its Influencing Factors in Virtual Emergency Situations” that examines how AI technology, such as virtual reality simulations, can improve understanding of students’ ability to respond to emergency situations.

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Sutton, Halley. "Study examines college transition for students with ADHD." Student Affairs Today 24, no. 8 (October 17, 2021): 5. http://dx.doi.org/10.1002/say.30984.

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Gelpi, Aileen. "Should college have known student might hurt peer?" Student Affairs Today 20, no. 4 (June 20, 2017): 8. http://dx.doi.org/10.1002/say.30356.

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Gelpi, Aileen. "Was college liable for attack against a student?" Student Affairs Today 20, no. 7 (September 19, 2017): 8. http://dx.doi.org/10.1002/say.30390.

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McCarthy, Claudine. "Map out your journey to the college presidency." Student Affairs Today 22, no. 2 (April 17, 2019): 12. http://dx.doi.org/10.1002/say.30611.

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Gelpi, Aileen. "Was college liable for 3rd-party provider's policies?" Student Affairs Today 18, no. 6 (August 20, 2015): 8. http://dx.doi.org/10.1002/say.30111.

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Elfman, Lois. "Student affairs career path leads to college presidency." Student Affairs Today 26, no. 8 (October 18, 2023): 12. http://dx.doi.org/10.1002/say.31311.

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Berenecea Johnson Eanes, Ph.D., President of York College (City University of New York), embraces creating and sustaining supportive networks, noting that succeeding in academic leadership requires like‐ minded people who share your goals. There's a distinct support system among the presidents of CUNY institutions, said Eanes, who's also a member of the Alpha Kappa Alpha Sorority. She attended a summit with a group of AKA college presidents. Eanes keeps the flyer with everyone's email addresses and phone numbers close at hand. “As women presidents, we tend to check on and look out for each other,” Eanes says.

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Patel, Munjal P., Mia Talmor, and William B. Nolan. "Botox and Collagen for Glabellar Furrows." Annals of Plastic Surgery 52, no. 5 (May 2004): 442–47. http://dx.doi.org/10.1097/01.sap.0000123806.03865.4d.

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Ginanjar, Agi, Mochamad Zakky Mubarok, and Dicky Oktora Mudzakir. "College Students' Motivation after Teaching Using Sport Education Season." International Journal of Human Movement and Sports Sciences 9, no. 4A (July 2021): 1–7. http://dx.doi.org/10.13189/saj.2021.091301.

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Hope, Joan. "College president shares insight into the presidential search process." Student Affairs Today 19, no. 7 (September 22, 2016): 12. http://dx.doi.org/10.1002/say.30261.

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McCarthy, Claudine. "Learn what it takes to become a college president." Student Affairs Today 20, no. 11 (January 17, 2018): 12. http://dx.doi.org/10.1002/say.30442.

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Schmidt, Volker J., Johanna O. Wietbrock, Nico Leibig, Torsten Gloe, Dominic Henn, J. Frederik Hernekamp, Leila Harhaus, and Ulrich Kneser. "Collagen-Elastin and Collagen-Glycosaminoglycan Scaffolds Promote Distinct Patterns of Matrix Maturation and Axial Vascularization in Arteriovenous Loop–Based Soft Tissue Flaps." Annals of Plastic Surgery 79, no. 1 (July 2017): 92–100. http://dx.doi.org/10.1097/sap.0000000000001096.

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G.Velmurugan, G. Velmurugan, and Dr A. Palanisamy Dr.A.Palanisamy. "Effects of Saq Training and Plyometric Training on Speed Among College Men Kabaddi Players." Indian Journal of Applied Research 3, no. 11 (October 1, 2011): 432–33. http://dx.doi.org/10.15373/2249555x/nov2013/138.

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43

Caviness, Perry Carter, Takaki Koide, Osamu Matsushita, and Joshua Sakon. "Using Small Angle X‐ray Scattering to determine the role of Poly‐cystic kidney disease‐like domains in Clostridium histolyticum." FASEB Journal 31, S1 (April 2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.lb126.

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Clostridium histolyticum is a bacterium that produces two collagen dismantling enzymes, i.e. Col H and Col G. Both collagenases have multi‐domain structures consisting of a catalytic module (S1) Polycystic kidney disease‐like domains (PKDs: S2A and S2B for Col H, S2 in Col G), named for containing the V‐set Ig fold first found in the polycystic kidney disease protein and collagen binding domains (CBDs: S3 for Col H, S3A and S3B for Col G). The three PKD domains are structurally similar and bind to one calcium ion. It is unknown what role the PKD domain plays in both Col H and Col G. Collagen binding assays for S2BS3 and S3 revealed that S2BS3 binds to collagen in two steps. S2BS3 was also shown to bind tighter to collagen than S3. PKD domains for Col H contain surface aromatic residues, similar to the collagen binding cleft for CBD. It is speculated that the surface aromatic residues on S2A (Tyr689 and Phe712) and S2B (Tyr780, His782, Tyr796 and Tyr801) assist in collagen binding. S2 lacks surface aromatic residues suggesting that it is a spacing domain. Small angle x‐ray scattering (SAXS) samples were prepared for S2AS2BS3, S2BS3 and S2S3AS3B with each bound mini‐collagen. After data collection envelopes were prepared. Solved crystal structures of each segment were fit into the SAXS envelope. S2B was found to make contact with the mini‐collagen while S2 did not make contact. Site directed mutagenesis of surface aromatic residues on S2B will need to be performed to confirm their role in collagen binding. A fusion protein consisting of basic FGF‐PKD‐CBD was found to accelerate osteogenesis in preclinical models for bone fracture and spinal fusion. The presence of the PKD domain may accelerate the wound healing process with less potential for side effects. Our study will help understand the molecular mechanism of the promising drug candidate.Support or Funding InformationSupported by a grant from NIGMS (P20 GM103429) at NIH.Travel funds supported by University of Arkansas Graduate School.

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Nie, Lanlan, Yali Wang, Xi Chen, Xinpei Lu, Lu Gan, Dongrong Liu, and Jun Shi. "Inhibitory effects and mechanisms of low-temperature plasma on hypertrophic scar." AIP Advances 13, no. 12 (December 1, 2023). http://dx.doi.org/10.1063/5.0159185.

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Recent advancements in comprehending the properties of low-temperature plasmas (LTPs) have spurred the creation of plasma medicine. Nonetheless, there exists limited scientific evidence concerning its mechanism of impeding proliferative scarring. This study aims to investigate the role of LTPs in hypertrophic scar (HS) formation. Establishing rabbit ear scar models, two groups were individually treated with salvianolic acid B (SAB) gel and low-temperature plasmas for six weeks, while the control group was not treated. The expression levels of cytokines, including TGF-β1, p-Smad3, and MMP-2, in rabbit serum were assessed using ELISA in this study. Additionally, hematoxylin-eosin staining and Masson’s trichrome staining were conducted on proliferative scar tissue to observe the arrangement of collagen fibers and determine the density of fibroblasts. Immunohistochemical analysis was also performed to obtain the percentage of type I collagen and α-SMA positive expression area. The findings indicated that the scars in both the SAB and LTP groups were narrower than those in the model group. The scar tissues treated with LTP or SAB showed a lower level of TGF-β1 and p-Smad3. In addition, α-SMA was significantly reduced in the LTP-treated group. Furthermore, the type I collagen expression was lower in the LTP group. These results suggest that LTP could have a comparable effect to SAB in hindering the development of HSs. It could potentially enhance skin scarring by impeding collagen deposition and fibroblast proliferation in HSs via the TGF-β/Smad signaling pathway. This investigation may provide a new perspective on HS treatment.

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White, Bryan P., Katie E. Barber, and Daniel B. Chastain. "Variation Among Infectious Diseases Pharmacists for the Treatment of Staphylococcus aureus Bacteremia." Journal of Pharmacy Practice, August 16, 2021, 089719002110388. http://dx.doi.org/10.1177/08971900211038864.

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Introduction Staphylococcus aureus bacteremia (SAB) remains complex, in that optimal treatment for patients, including complicated or persistent infection, remains unclear. Two recent surveys have demonstrated practice variations in SAB among infectious diseases (ID) physicians. Objectives The purpose of this survey was to examine practice variations in SAB among ID pharmacists. Methods A thirty-five-question survey was electronically distributed to the American College of Clinical Pharmacy (ACCP) Infectious Diseases Practice and Research Network (IDPRN) in Fall 2019 to determine differences in SAB management. Data were analyzed utilizing Pearson’s Chi-Square or Fisher’s Exact Test. Results A total of 106 ID pharmacists responded. Only 28% of pharmacists practiced at hospitals with mandatory ID consultation for SAB. A majority (75%) had rapid diagnostic technology (RDT) for identifying SABSI, but 32% of those facilities with RDT did not notify pharmacy with results. Anti-staphylococcal penicillins were preferred for MSSA blood stream infections (BSI) in patients with central nervous system infection and endocarditis, whereas cefazolin was favored for other MSSA BSI. For persistent MRSA BSI, 34% selected daptomycin alone while 38% elected to combine daptomycin and ceftaroline. Pharmacists at hospitals less than 500 beds were more likely to use daptomycin, while those at larger hospitals were more likely to use daptomycin and ceftaroline for persistent MRSA BSI ( P < .05). Conclusions A survey of ID pharmacists showed variation in the management of SABs, as well as the definition and treatment of persistent SAB. Mandatory ID consultation and RDT use to improve SAB management have not been optimized.

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Wen, Feiying, Shengmiao Zhang, Liqin Sun, Manqing Qian, and Haofeng Xu. "Salvianolic acid B inhibits oxidative stress in glomerular mesangial cells alleviating diabetic nephropathy by regulating SIRT3/FOXO1 signaling." Kidney and Blood Pressure Research, November 7, 2023. http://dx.doi.org/10.1159/000534832.

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Introduction: Oxidative stress is pivotal in advancing diabetic nephropathy (DN). Salvianolic acid B (SAB), derived from Radix Salviae miltiorrhizae, exhibits renoprotective effects. However, the mechanisms underlying its action in DN are not fully elucidated. This study explores SAB’s protective effect on DN, focusing on its antioxidative properties in glomerular mesangial cells. Methods: The renoprotective effects of various SAB dosages on DN rats were assessed by evaluating kidney tissue pathological alterations through hematoxylin-eosin (H&E), periodic acid-Schiff (PAS), Masson, TUNEL staining and kidney function through biochemical detection. CCK8 and lactate dehydrogenase (LDH) cytotoxicity assays were utilized to evaluate the viability of high glucose (HG)-induced HBZY-1 cells treated with various SAB dosages. Oxidative stress and inflammation levels were measured using enzyme-linked immunosorbent assay (ELISA) kits. The Sirtuin 3 (SIRT3)/Forkhead box transcription factor O1 (FOXO1) pathway was examined through Western blot and immunohistochemistry. Results: SAB mitigated kidney histopathological alterations and function and cell apoptosis in DN rats at various dosages. It enhanced the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) while decreasing reactive oxygen species (ROS) and malondialdehyde (MDA) levels both in vivo and in vitro. SAB also suppressed the levels of pro-inflammatory cytokines (IL-1β, IL-6, MCP-1, and TNF-α) and the expression of collagen IV and fibronectin in HG-induced HBZY-1 cells. Furthermore, SAB activated the SIRT3/FOXO1 signaling pathway. Conclusion: Our findings suggest that SAB may alleviate oxidative stress in DN both in vivo and in vitro, potentially through the activation of the SIRT3/FOXO1-mediated signaling pathway. This study provides initial insights into the possible antioxidative and renoprotective effects of SAB, indicating its potential utility as a therapeutic agent for DN.

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Sung, Jee Eun, Heekyung Ahn, Sujin Choi, and Kiseop Lee. "Age and Education Effects on a Novel Syntactic Assessment Battery for Elderly Adults." Frontiers in Psychology 12 (June 18, 2021). http://dx.doi.org/10.3389/fpsyg.2021.639866.

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The purpose of this study was to delineate the properties of a novel syntactic assessment battery and to present descriptive data on normal elderly individuals. We administered the Syntactic Assessment Battery (hereinafter SAB) using a sentence-picture paradigm to 195 normal elderly adults in three age groups (60–69, 70–79, and 80–90) and five educational levels (No formal education, Elementary School Graduation, Middle School Graduation, High School Graduation, College Graduation and Above). A multiple linear regression model was applied to verify the age and education effects. A summary of results indicated that the SAB effectively detected age and education effects. People generally demonstrated worse performance as they aged but better performance as their educational levels increased. People with high school education and above generally demonstrated stronger performance on the test, although educational effects were not significantly different between elementary and middle school graduation groups. The current novel syntactic assessment battery can serve as a screening measure that sensitively detects age and education effects.

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Yan, Yan, Min Zhou, Ke Meng, Chuanhai Zhou, Xiaoyu Jia, Xinhao Li, Dedong Cui, et al. "Salvianolic acid B attenuates inflammation and prevent pathologic fibrosis by inhibiting CD36-mediated activation of the PI3K-Akt signaling pathway in frozen shoulder." Frontiers in Pharmacology 14 (August 1, 2023). http://dx.doi.org/10.3389/fphar.2023.1230174.

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Frozen shoulder (FS) is characterized by pain and limited range of motion (ROM). Inflammation and fibrosis are accepted as main pathologic processes associated with the development of FS. However, the intrinsic mechanisms underlying pathologic fibrosis remain unclear. We aimed to elucidate the key molecules involved in pathologic fibrosis and explore new therapeutic targets for FS. Synovial fibroblasts isolated from patient biopsies were identified using immunofluorescence. Western blotting, RT-qPCR, cell adhesion tests, and would-healing assays were used to evaluate the fibrosis-related functions of synovial fibroblasts. Elevated cluster of differentiation 36 (CD36) expression was detected in FS using Western blotting and immunohistochemistry. Salvianolic acid b (SaB) inhibited CD36, blocking synovial fibroblast-induced inflammation and fibrosis. Our RNA-seq data showed that knocking down CD36 dramatically impaired the capacity of synovial fibroblasts for cell adhesion and that the PI3K-Akt signaling pathway may be crucial to the fibrotic process of FS. By up-regulating CD36 and inhibiting the phosphorylation of Akt, we demonstrated that CD36 promotes pathologic fibrosis by activating the PI3k-Akt pathway. Finally, rats treated with SaB had improved ROM and less collagen fiber deposition than the FS model group.Conclusion: SaB attenuates inflammation and inhibited the CD36-mediated activation of the PI3K-Akt signaling pathway to block pathologic fibrosis of FS in vitro and in vivo models.

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"First person – Sarah Escuin and Saba Raza-Knight." Disease Models & Mechanisms 16, no. 3 (March 1, 2023). http://dx.doi.org/10.1242/dmm.050105.

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ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Sarah Escuin and Saba Raza-Knight are co-first authors on ‘ Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse’, published in DMM. Sarah conducted the research described in this article while a research associate in the lab of Prof. Andrew Copp at University College London, London, UK, investigating the mechanisms of neurulation and identifying the causes underlying neural tube defects. Saba conducted the research described in this article while an MB PhD student in the lab of Prof. Andrew Copp and Prof. Nicholas Greene at University College London, London, UK. She is now a specialty trainee in neurosurgery at Salford Royal Hospital, Salford, UK, and an honorary clinical lecturer at the University of Manchester, Manchester, UK, investigating neurovascular disorders, cancer biology and genetics, and hydrocephalus, with an active role in medical education.

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"Judge rules against college." Student Affairs Today 23, no. 12 (February 16, 2021): 11. http://dx.doi.org/10.1002/say.30873.

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